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Bradley Hyman

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Katherine J Kopeikina; Rose Pitstick; Manuela Polydoro; George A Carlson; Bradley T Hyman; Hwan-Ching Tai; Erich Yaeger; Tara L Spires-Jones
Synaptic alterations in the rTg4510 mouse model of tauopathy.
Lary C Walker; Marc I Diamond; Karen E Duff; Bradley T Hyman
Mechanisms of protein seeding in neurodegenerative diseases.
Anke Wahler; Björn von Einem; Anja-Silke Beyer; Tobias M Boeckers; Bradley T Hyman; Ilona E Keller; Ithan D Peltan; Christian Pröpper; Cathrin Schnack; Dudley K Strickland; Christine A F Von Arnim
Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).

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2013: Katherine J Kopeikina; Rose Pitstick; Manuela Polydoro; George A Carlson; Bradley T Hyman; Hwan-Ching Tai; Erich Yaeger; Tara L Spires-Jones
Synaptic alterations in the rTg4510 mouse model of tauopathy.
The Journal of comparative neurology 2013;521(6):1334-53.
2013: Lary C Walker; Marc I Diamond; Karen E Duff; Bradley T Hyman
Mechanisms of protein seeding in neurodegenerative diseases.
JAMA neurology 2013;70(3):304-10.
2013: Anke Wahler; Björn von Einem; Anja-Silke Beyer; Tobias M Boeckers; Bradley T Hyman; Ilona E Keller; Ithan D Peltan; Christian Pröpper; Cathrin Schnack; Dudley K Strickland; Christine A F Von Arnim
Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1).
The Biochemical journal 2013;450(2):333-43.
2013: Xuejing Li; Christina M Lill; Navine Nasser-Ghodsi; Isabella Palazzolo; Kengo Uemura; Muriel Arimon; Tadafumi Hashimoto; Bradley T Hyman; Dimitri Krainc; Oksana Berezovska
Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions.
Neurobiology of disease 2013;50():127-34.
2013: Brian D Adair; José Luis Alonso; Bradley T Hyman; Jian-Ping Xiong; M Amin Arnaout
EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane.
PloS one 2013;8(2):e57951.
2012: Tadafumi Hashimoto; David M Holtzman; Yukiko Hori; Kenneth W Adams; Brian J Bacskai; Adrian Olaf Banerji; Mary Beth Finn; Matthew P Frosch; Daniel Joyner; Akinori Mitani; Alberto Serrano-Pozo; Tara L Spires-Jones; Shuko Takeda; Diana H Thyssen; Bradley T Hyman
Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(43):15181-92.
2012: Nikita Rudinskiy; Tara L Spires-Jones; Shun Yamaguchi; Rebecca A Betensky; Megumi Eguchi; Jonathan M Hawkes; Bradley T Hyman
Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease.
Nature neuroscience 2012;15(10):1422-9.
2012: Robert M Koffie; Katherine J Kopeikina; Virginia M Lee; Alberto Serrano-Pozo; Matthew P Frosch; Tadafumi Hashimoto; David M Holtzman; Steven Hou; Bradley T Hyman; Daniel Joyner; Kevin R Kay; Hwan-Ching Tai; Tara L Spires-Jones
Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β.
Brain : a journal of neurology 2012;135(Pt 7):2155-68.
2012: Olivia I Okereke; Norberto Pantoja-Galicia; Taylor Wanggaard; Marilyn S Albert; Rebecca A Betensky; Maura Copeland; Bradley T Hyman; Deborah Blacker
The SIST-M: predictive validity of a brief structured clinical dementia rating interview.
Alzheimer disease and associated disorders 2012;26(3):225-31.
2012: Bradley T Hyman; Junying Yuan
Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology.
Nature reviews. Neuroscience 2012;13(6):395-406.
2012: Hai-Yan Wu; Kengo Uemura; Brian J Bacskai; Oksana Berezovska; Zhan-Yun Fan; Cynthia L Grosskreutz; Tadafumi Hashimoto; Eloise Hudry; Bradley T Hyman
Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(15):5298-309.
2012: Anja-Silke Beyer; Tobias M Böckers; Ekta S Chhabra; Meihua Deng; Anke Hellrung; Bradley T Hyman; Martin Ingelsson; Ilona E Keller; Alexandra Makarova; Christian Pröpper; Daniel Schwanzar; Dietmar R Thal; Bjoern von Einem; Christine A F Von Arnim
Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein.
Neurobiology of aging 2012;33(4):732-43.
2012: Nathan Pankratz; Haydeh Payami; Owen A Ross; Clemens R Scherzer; William Scott; David K Simon; Caroline Tanner; Jeffery Vance; Zbigniew K Wszolek; Cyrus Zabetian; Gary Beecham; LN Clark; Ted M Dawson; Anita L DeStefano; Kimberly F Doheny; Stewart A Factor; Tatiana Foroud; Taye H Hamza; Albert Y Hung; Bradley T Hyman; Adrian J Ivinson; Dmitri Krainc; Jeanne C Latourelle; Karen Marder; Eden R Martin; Richard Mayeux; Richard H Myers
Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.
Annals of neurology 2012;71(3):370-84.
2012: Eloise Hudry; Roland Matsouaka; Tara L Spires-Jones; Hai-Yan Wu; Michal Arbel-Ornath; Brian J Bacskai; Rebecca A Betensky; Zhanyun Fan; Tadafumi Hashimoto; Bradley T Hyman
Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(9):3176-92.
2012: Alix de Calignon; David H Adamowicz; Karen K. Hsiao Ashe; George A Carlson; Kathy J Kopeikina; Rose Pitstick; Manuela Polydoro; Naruhiko Sahara; Tara L Spires-Jones; Marc Suarez-Calvet; Christopher William; Bradley T Hyman
Propagation of tau pathology in a model of early Alzheimer's disease.
Neuron 2012;73(4):685-97.
2012: Juan Qu; Rebecca A Betensky; Bradley T Hyman; Roland Matsouaka; Cynthia L Grosskreutz
Calcineurin activation causes retinal ganglion cell degeneration.
Molecular vision 2012;18():2828-38.
2012: Luxiang Cao; Sarah R Edwards; Todd E Golde; Alexis C Gomez; Bradley T Hyman; Yona Levites; Thomas W Moulia; Gregory T Rickenbacher; Steve Rodriguez; Benjamin R Schrank; Gilad Barnea; Eric G Benz; Mark W Albers
Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo.
Nature communications 2012;3():1009.
2012: Bradley T Hyman; Eliezer Masliah; Suzanne S Mirra; Thomas G Beach; Eileen H Bigio; Nigel J Cairns; Maria C Carrillo; Dennis W Dickson; Charles Duyckaerts; Matthew P Frosch; Peter T Nelson; Creighton H Phelps; Julie A Schneider; Dietmar R Thal; Bill Thies; John Q Trojanowski; Harry V Vinters; Thomas J Montine
National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2012;8(1):1-13.
2012: B DaRocha-Souto; Z Fan; I Barroeta; M Coma; T Hashimoto; E Hudry; Bradley T Hyman; B G Pérez-Nievas; M Rodríguez; M B Sánchez; P Sánchez-Ferrer; T C Scotton; L Serenó; M Siao; Teresa Gómez-Isla
Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease.
Neurobiology of disease 2012;45(1):425-37.
2011: Robert M Koffie; Laiq-Jan Saidi; Christian T Farrar; Bradley T Hyman; Christopher M William; Tara L Spires-Jones
Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(46):18837-42.
2011: Marka van Blitterswijk; Robert H Brown; Merit E Cudkowicz; Sunita Gulati; Bradley T Hyman; Adrian J Ivinson; Matthew Jaffa; Nancy Maher; Clemens R Scherzer; David A Schoenfeld; Elizabeth Smoot; Daryl A Bosco
Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases 2011;12(6):430-8.
2011: Tara L Spires-Jones; Alix de Calignon; Robert M Koffie; Katherine J Kopeikina; Bradley T Hyman
Are tangles as toxic as they look?
Journal of molecular neuroscience : MN 2011;45(3):438-44.
2011: Darius Ebrahimi-Fakhari; Zhanyun Fan; Bradley T Hyman; Eliezer Masliah; Pamela J McLean; Edward Rockenstein; Ippolita Cantuti-Castelvetri; Vivek K Unni
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(41):14508-20.
2011: Hongliu Ding; Alice W Flaherty; John H Growdon; Michael T Hayes; Albert Y Hung; Bradley T Hyman; Adrian J Ivinson; Caroline G Kan; Nancy E Maher; Bernard M Ravina; Sarah S Roderick; Andrea Santarlasci; Alison K Sarokhan; Michael G Schlossmacher; Michael A Schwarzschild; Dennis J Selkoe; U Shivraj Sohur; Lewis R Sudarsky; Kyleen E Swords; Vivek K Unni; Anne-Marie Wills; Paymon Ashourian; Rachit Bakshi; Sunny Chang; Clemens R Scherzer
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
Movement disorders : official journal of the Movement Disorder Society 2011;26(12):2283-6.
2011: Katherine J Kopeikina; Adam E Ludvigson; Jennifer I Luebke; Alan Peters; Rose Pitstick; George A Carlson; Matthew P Frosch; Bradley T Hyman; Robert M Koffie; Tara L Spires-Jones
Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain.
The American journal of pathology 2011;179(4):2071-82.
2011: Alberto Serrano-Pozo; Matthew L Mielke; Rebecca A Betensky; Matthew P Frosch; Teresa Gómez-Isla; John H Growdon; Bradley T Hyman
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease.
The American journal of pathology 2011;179(3):1373-84.
2011: Tadafumi Hashimoto; Kenneth W Adams; Zhanyun Fan; Pamela J McLean; Bradley T Hyman
Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay.
The Journal of biological chemistry 2011;286(31):27081-91.
2011: Bradley T Hyman
Amyloid-dependent and amyloid-independent stages of Alzheimer disease.
Archives of neurology 2011;68(8):1062-4.
2011: Sripriya Ranganathan; Elizabeth Smith; Jeffrey A Winkles; Manuel Yepes; Frances D Battey; Bradley T Hyman; Molly Migliorini; Irina Mikhailenko; Nathaniel C Noyes; Dudley K Strickland
LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(30):10836-46.
2011: Niklas Mattsson; John McAuliffe; Marc Mercken; Abhay Moghekar; José Luis Molinuevo; Thomas J Montine; William Nowatzke; Richard J O'Brien; Markus Otto; George P Paraskevas; Lucilla Parnetti; Staffan Persson; Ronald C. Petersen; David Prvulovic; Robert A Rissman; Elio Scarpini; Johannes Schröder; Leslie M Shaw; Anders Skinningsrud; Brith Skrogstad; Hilkka Soininen; Annette Spreer; Alessandro Stefani; Leda Talib; Charlotte Teunissen; John Q Trojanowski; Hayrettin Tumani; Robert M Umek; Bianca Van Broeck; hugo Marcel vanderstichele; Laszlo Vecsei; Marcel M Verbeek; Manfred Windisch; Henrik Zetterberg; Jing Zhang; Luisella Bocchio-Chiavetto; Maria C Carrillo; Sonia Chalbot; Davide Chiasserini; Els Coart; Neal Cutler; Gunilla Dahlfors; Herman P M de Reus; Stefan Duller; Anne M Fagan; Orestes Forlenza; Giovanni B Frisoni; Douglas Galasko; Daniela Galimberti; Harald Hampel; Aase Handberg; Michael T Heneka; Adrianna Z Herskovits; Sanna-Kaisa Herukka; David M Holtzman; Christian Humpel; Bradley T Hyman; Khalid Iqbal; Mathias Jucker; Stephan A Kaeser; Elmar Kaiser; Elisabeth Kapaki; Daniel Kidd; Peter Klivenyi; Cindy S Knudsen; Markus P Kummer; Piotr Lewczuk; Qiao-Xin Li; Albert Lladó; James Lui; Ralph Martins; Colin L Masters; Ulf Andreasson; Hiroyuki Arai; Sat Dev Batish; Sergio Bernardini; Marinus A Blankenstein; Kaj Blennow
The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):386-395.e6.
2011: Reisa Sperling; William Thies; Eric R Siemers; Martin M Bednar; Ronald S Black; Sandra E Black; H Robert Brashear; Maria C Carrillo; Howard H Feldman; Matthew P Frosch; Steven M Greenberg; Michael Grundman; Bradley T Hyman; Clifford R Jack; Philip scheltens; Rachel J Schindler
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(4):367-85.
2011: Leora M Fox; David H Adamowicz; George A Carlson; Rose Pitstick; Tara L Spires-Jones; Christopher M William; Bradley T Hyman
Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model.
Journal of neuropathology and experimental neurology 2011;70(7):588-95.
2011: John H Growdon; Bradley T Hyman
Plasma beta-amyloid linked to cognitive decline.
Archives of neurology 2011;68(6):799-801.
2011: Gregory Crosby; Deborah J Culley; Bradley T Hyman
Preoperative cognitive assessment of the elderly surgical patient: a call for action.
Anesthesiology 2011;114(6):1265-8.
2011: Guy M McKhann; David S. Knopman; Howard Chertkow; Bradley T Hyman; Clifford R Jack; Claudia H Kawas; William E Klunk; Walter J Koroshetz; Jennifer Manly; Richard Mayeux; Richard C Mohs; John C Morris; Martin N Rossor; Philip scheltens; Maria C Carrillo; Bill Thies; Sandra Weintraub; Creighton H Phelps
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2011;7(3):263-9.
2011: Bibiana DaRocha-Souto; Thomas C Scotton; Mireia Coma; Alberto Serrano-Pozo; Tadafumi Hashimoto; Lidia Serenó; Marta Rodríguez; Belen Sánchez; Bradley T Hyman; Teresa Gómez-Isla
Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice.
Journal of neuropathology and experimental neurology 2011;70(5):360-76.
2011: Adam C Naj; Gyungah Jun; Gary Beecham; Li-San Wang; Badri Narayan Vardarajan; Jacqueline Buros; Paul J Gallins; Joseph Buxbaum; Gail P Jarvik; Paul K Crane; Eric B Larson; Thomas D Bird; Bradley F Boeve; Neill R Graff-Radford; Philip L De Jager; Denis Evans; Julie A Schneider; Minerva M Carrasquillo; Nilufer Ertekin-Taner; Steven G Younkin; Carlos Cruchaga; John S K Kauwe; Petra Nowotny; Patricia Kramer; John Hardy; Matthew Huentelman; Amanda Myers; M. Michael Barmada; F Yesim Demirci; Clinton T Baldwin; Robert C Green; Ekaterina Rogaeva; Steven E Arnold; Robert C Barber; Thomas Beach; Eileen H Bigio; James D Bowen; Adam Boxer; James R Burke; Nigel J Cairns; Chris S Carlson; Regina M Carney; Steven L Carroll; Helena C Chui; David G Clark; Jason Corneveaux; Carl W Cotman; Jeffrey L Cummings; Charles DeCarli; Steven T DeKosky; Ramon Diaz-Arrastia; Malcolm Dick; dennis dickson; William G Ellis; Kelley M Faber; Kenneth B Fallon; Martin R Farlow; Steven Ferris; Matthew P Frosch; Douglas Galasko; Mary Ganguli; Marla Gearing; Daniel Geschwind; Bernardino Ghetti; John Gilbert; Sid Gilman; Bruno Giordani; Jonathan D Glass; John H Growdon; Ronald L Hamilton; Lindy E Harrell; Elizabeth Head; Lawrence Honig; Christine M Hulette; Bradley T Hyman; Gregory A Jicha; Lee-Way Jin; Nancy Johnson; Jason Karlawish; Anna Karydas; Jeffrey A Kaye; Ronald Kim; Edward H Koo; Neil W Kowall; James J Lah; Allan Levey; Andrew P Lieberman; Oscar L Lopez; Wendy J Mack; Daniel C Marson; Frank Martiniuk; Deborah C Mash; Eliezer Masliah; Wayne C McCormick; Susan M McCurry; Andrew N McDavid; Ann C McKee; Marsel Mesulam; Bruce L Miller; Carol A Miller; Joshua Miller; Joseph E Parisi; Daniel P Perl; Elaine Peskind; Ronald C. Petersen; Wayne W Poon; Joseph F Quinn; Ruchita A Rajbhandary; Murray Raskind; Barry Reisberg; John M Ringman; Erik D Roberson; Roger N Rosenberg; Mary Sano; Lon S Schneider; William Seeley; Michael L Shelanski; Michael Slifer; Charles D Smith; Joshua A Sonnen; Salvatore Spina; Robert A Stern; Rudolph E Tanzi; John Q Trojanowski; Juan C Troncoso; Vivianna M Van Deerlin; Harry V Vinters; Jean Paul Vonsattel; Sandra Weintraub; Kathleen A Welsh-Bohmer; Jennifer Williamson; Randall L Woltjer; Laura B Cantwell; Beth A Dombroski; Duane Beekly; Kathryn L Lunetta; Eden R Martin; M Ilyas Kamboh; Andrew J Saykin; Eric Reiman; David A Bennett; John C Morris; Thomas J Montine; Alison Goate; Deborah Blacker; Debby W Tsuang; Hakon Hakonarson; Walter A Kukull; Tatiana M Foroud; Jonathan L Haines; Richard Mayeux; Margaret Pericak-Vance; Lindsay A Farrer; Peter St George-Hyslop; Gerard D Schellenberg
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
Nature genetics 2011;43(5):436-41.
2011: Bradford C Dickerson; T R Stoub; R C Shah; R A Sperling; R J Killiany; Marilyn S Albert; Bradley T Hyman; Deborah Blacker; L Detoledo-Morrell
Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults.
Neurology 2011;76(16):1395-402.
2011: Lena Skoglund; Toshifumi Matsui; Stefanie H Freeman; Anders Wallin; Elin S Blom; Matthew P Frosch; John H Growdon; Bradley T Hyman; Lars Lannfelt; Martin Ingelsson; Anna Glaser
Novel progranulin mutation detected in 2 patients with FTLD.
Alzheimer disease and associated disorders 2011;25(2):173-8.
2011: Olivia I Okereke; Maura Copeland; Bradley T Hyman; Taylor Wanggaard; Marilyn S Albert; Deborah Blacker
The Structured Interview & Scoring Tool-Massachusetts Alzheimer's Disease Research Center (SIST-M): development, reliability, and cross-sectional validation of a brief structured clinical dementia rating interview.
Archives of neurology 2011;68(3):343-50.
2011: Vivek K Unni; Darius Ebrahimi-Fakhari; Charles R Vanderburg; Pamela J McLean; Bradley T Hyman
Studying protein degradation pathways in vivo using a cranial window-based approach.
Methods (San Diego, Calif.) 2011;53(3):194-200.
2011: Tara L Spires-Jones; Alix de Calignon; Melanie Meyer-Luehmann; Brian J Bacskai; Bradley T Hyman
Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging.
Methods (San Diego, Calif.) 2011;53(3):201-7.
2011: Jayashree Viswanathan; Annakaisa Haapasalo; Claudia Böttcher; Riitta Miettinen; Kaisa M A Kurkinen; Alice Lu; Anne Thomas; Christa J Maynard; Donna Romano; Bradley T Hyman; Oksana Berezovska; Lars Bertram; Hilkka Soininen; Nico P Dantuma; Rudolph E Tanzi; Mikko Hiltunen
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation.
Traffic (Copenhagen, Denmark) 2011;12(3):330-48.
2011: Anete Rozkalne; Bradley T Hyman; Tara L Spires-Jones
Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice.
Neurobiology of disease 2011;41(3):650-4.
2011: Tara L Spires-Jones; Kevin Kay; Roland Matsouka; Anete Rozkalne; Rebecca A Betensky; Bradley T Hyman
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.
Neuroscience letters 2011;487(3):260-3.
2011: Carli Lattarulo; Diana Thyssen; Bradley T Hyman; Kishore V Kuchibholta; Brian J Bacskaiq
Microscopic imaging of intracellular calcium in live cells using lifetime-based ratiometric measurements of Oregon Green BAPTA-1.
Methods in molecular biology (Clifton, N.J.) 2011;793():377-89.
2011: Robert M Koffie; Bradley T Hyman; Tara L Spires-Jones
Alzheimer's disease: synapses gone cold.
Molecular neurodegeneration 2011;6(1):63.
2011: Melanie Meyer-Luehmann; J Rodrigo Mora; Matthew Mielke; Tara L Spires-Jones; Alix de Calignon; Ulrich H von Andrian; Bradley T Hyman
T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice.
Molecular neurodegeneration 2011;6():22.
2011: Lorraine V Kalia; Suneil K Kalia; Hien Chau; Andres M Lozano; Bradley T Hyman; Pamela J McLean
Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).
PloS one 2011;6(2):e14695.
2011: Phillip B Jones; Kenneth W Adams; Anete Rozkalne; Tara L Spires-Jones; Tammy T Hshieh; Tadafumi Hashimoto; Christine A F von Armin; Mathew Mielke; Brian J Bacskai; Bradley T Hyman
Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain.
PloS one 2011;6(1):e14586.
2011: Bradley T Hyman
Caspase activation without apoptosis: insight into Aβ initiation of neurodegeneration.
Nature neuroscience 2011;14(1):5-6.
2011: Karin M Danzer; Wolfgang P Ruf; Preeti Putcha; Daniel Joyner; Tadafumi Hashimoto; Charles G Glabe; Bradley T Hyman; Pamela J McLean
Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(1):326-36.
2010: Monica Garcia-Alloza; Laura A Borrelli; Bradley T Hyman; Brian J Bacskai
Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.
Neurobiology of aging 2010;31(12):2058-68.
2010: Alix de Calignon; Tara L Spires-Jones; Bradley T Hyman
[Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease].
Médecine sciences : M/S 2010;26(10):787-9.
2010: Mélanie Beaujouin; Christine Prébois; Danielle Derocq; Valérie Laurent-Matha; Olivier Masson; Sophie Pattingre; Peter Coopman; Nadir Bettache; Jami Grossfield; Robert E Hollingsworth; Hongyu Zhang; Zemin Yao; Bradley T Hyman; Peter van der Geer; Gary K Smith; Emmanuelle Liaudet-Coopman
Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.
Journal of cell science 2010;123(Pt 19):3336-46.
2010: Dan Yi Wang; Arjun Ray; Kathryn Rodgers; Ceren Ergorul; Bradley T Hyman; Wei Huang; Cynthia L Grosskreutz
Global gene expression changes in rat retinal ganglion cells in experimental glaucoma.
Investigative ophthalmology & visual science 2010;51(8):4084-95.
2010: Alberto Serrano-Pozo; Gloria L Vega; Dieter Lütjohann; Joseph J Locascio; Marsha K Tennis; Amy Deng; Alireza Atri; Bradley T Hyman; Michael C Irizarry; John H Growdon
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.
Alzheimer disease and associated disorders 2010;24(3):220-6.
2010: M Coma; L Serenó; B Da Rocha-Souto; T C Scotton; J España; M B Sánchez; M Rodríguez; J Agulló; C Guardia-Laguarta; Monica Garcia-Alloza; L A Borrelli; Jordi Clarimón; Alberto Lleó; Brian J Bacskai; C A Saura; Bradley T Hyman; Teresa Gómez-Isla
Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease.
Neurobiology of disease 2010;38(3):482-91.
2010: Alberto Serrano-Pozo; Christopher M William; Isidro Ferrer; Emmanuelle Uro-Coste; Marie-Bernadette Delisle; Claude-Alain Maurage; Christoph Hock; Roger M Nitsch; Eliezer Masliah; John H Growdon; Matthew P Frosch; Bradley T Hyman
Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology.
Brain : a journal of neurology 2010;133(Pt 5):1312-27.
2010: Alix de Calignon; Leora M Fox; Rose Pitstick; George A Carlson; Brian J Bacskai; Tara L Spires-Jones; Bradley T Hyman
Caspase activation precedes and leads to tangles.
Nature 2010;464(7292):1201-4.
2010: Preeti Putcha; Karin M Danzer; Lisa R Kranich; Anisa Scott; Melanie Silinski; Sarah Mabbett; Carol D Hicks; James M Veal; Paul M Steed; Bradley T Hyman; Pamela J McLean
Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity.
The Journal of pharmacology and experimental therapeutics 2010;332(3):849-57.
2010: Hai-Yan Wu; Eloise Hudry; Tadafumi Hashimoto; Kishore Kuchibhotla; Anete Rozkalne; Zhanyun Fan; Tara Spires-Jones; Hong Xie; Michal Arbel-Ornath; Cynthia L Grosskreutz; Brian J Bacskai; Bradley T Hyman
Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(7):2636-49.
2010: Noriko Fukumoto; Takashi Fujii; Onofre Combarros; M Ilyas Kamboh; Shin-Jen Tsai; Sachio Matsushita; Benedetta Nacmias; David E Comings; Humberto Arboleda; Martin Ingelsson; Bradley T Hyman; Hiroyasu Akatsu; Andrew Grupe; Agnes Lumi Nishimura; Mayana Zatz; Kari M Mattila; Juha Rinne; Yu-ichi Goto; Takashi Asada; Shun Nakamura; Hiroshi Kunugi
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010;153B(1):235-42.
2010: Elin S Blom; Yijing Wang; Lena Skoglund; Anita C Hansson; Massimo Ubaldi; Anbarasu Lourdusamy; Wolfgang Sommer; Matthew Mielke; Bradley T Hyman; Markus Heilig; Lars Lannfelt; Lars N G Nilsson; Martin Ingelsson
Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain.
International journal of Alzheimer's disease 2010;2011():936580.
2010: Vivek K Unni; Tamily A Weissman; Edward Rockenstein; Eliezer Masliah; Pamela J McLean; Bradley T Hyman
In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility.
PloS one 2010;5(5):e10589.
2010: Stephanie J Soscia; James E Kirby; Kevin J Washicosky; Stephanie M Tucker; Martin Ingelsson; Bradley T Hyman; Mark A Burton; Lee E Goldstein; Scott Duong; Rudolph E Tanzi; Robert D Moir
The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide.
PloS one 2010;5(3):e9505.
2010: Andreas S Hillmer; Preeti Putcha; Johannes Levin; Tobias Högen; Bradley T Hyman; Hans A Kretzschmar; Pamela J McLean; Armin Giese
Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron.
Biochemical and biophysical research communications 2010;391(1):461-6.
2009: Li Chen; Magali Periquet; Xu Wang; Alessandro Negro; Pamela J McLean; Bradley T Hyman; Mel B Feany
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
The Journal of clinical investigation 2009;119(11):3257-65.
2009: Melanie Meyer-Luehmann; Matthew Mielke; Tara L Spires-Jones; Will Stoothoff; Phill Jones; Brian J Bacskai; Bradley T Hyman
A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(40):12636-40.
2009: Will Stoothoff; Phillip B Jones; Tara L Spires-Jones; Daniel Joyner; Ekta Chhabra; Kathryn Bercury; Zhanyun Fan; Hong Xie; Brian J Bacskai; Jon Edd; daniel irimia; Bradley T Hyman
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.
Journal of neurochemistry 2009;111(2):417-27.
2009: Ola Philipson; Per Hammarström; K Peter R Nilsson; Erik Portelius; Tommie Olofsson; Martin Ingelsson; Bradley T Hyman; Kaj Blennow; Lars Lannfelt; Hannu Kalimo; Lars N G Nilsson
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.
Neurobiology of aging 2009;30(9):1393-405.
2009: Jian-Ping Xiong; Bhuvaneshwari Mahalingham; Jose Luis Alonso; Laura Ann Borrelli; Xianliang Rui; Saurabh Anand; Bradley T Hyman; Thomas Rysiok; Dirk Müller-Pompalla; Simon L Goodman; M Amin Arnaout
Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
The Journal of cell biology 2009;186(4):589-600.
2009: Bruce Fischl; Allison A Stevens; Niranjini Rajendran; B T Thomas Yeo; Douglas N Greve; Koen Van Leemput; Jonathan R Polimeni; Sita Kakunoori; Randy L Buckner; Jenni Pacheco; David H Salat; Jennifer Melcher; Matthew P Frosch; Bradley T Hyman; P Ellen Grant; Bruce R Rosen; André J W van der Kouwe; Graham C Wiggins; Lawrence L Wald; Jean C Augustinack
Predicting the location of entorhinal cortex from MRI.
NeuroImage 2009;47(1):8-17.
2009: Reisa Sperling; Peter S Laviolette; Kelly O'Keefe; Jacqueline O'Brien; Dorene M Rentz; Maija Pihlajamaki; Gad Marshall; Bradley T Hyman; Dennis J Selkoe; Trey Hedden; Randy L Buckner; J Alex Becker; Keith A Johnson
Amyloid deposition is associated with impaired default network function in older persons without dementia.
Neuron 2009;63(2):178-88.
2009: Anete Rozkalne; Tara L Spires-Jones; Edward A Stern; Bradley T Hyman
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model.
Brain research 2009;1280():178-85.
2009: Alix de Calignon; Tara L Spires-Jones; Rose Pitstick; George A Carlson; Bradley T Hyman
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.
Journal of neuropathology and experimental neurology 2009;68(7):757-61.
2009: Cristina Guardia-Laguarta; Mireia Coma; Marta Pera; Jordi Clarimón; Lidia Sereno; José M Agulló; Laura Molina-Porcel; Eduard Gallardo; Amy Deng; Oksana Berezovska; Bradley T Hyman; Rafael Blesa; Teresa Gómez-Isla; Alberto Lleó
Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
Journal of neurochemistry 2009;110(1):220-30.
2009: Hyang-Sook Hoe; kea joo lee; Rosalind S E Carney; Jiyeon Lee; Alexandra Markova; Ji-Yun Lee; Brian Howell; Bradley T Hyman; Daniel T S Pak; Guojun Bu; G. William Rebeck
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(23):7459-73.
2009: Lauren Herl; Anne V Thomas; Christina M Lill; Mary Banks; Amy Deng; Phill B Jones; Robert Spoelgen; Bradley T Hyman; Oksana Berezovska
Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.
Molecular and cellular neurosciences 2009;41(2):166-74.
2009: Nikolaus R McFarland; Zhanyun Fan; Kui Xu; Michael A Schwarzschild; Mel B Feany; Bradley T Hyman; Pamela J McLean
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Journal of neuropathology and experimental neurology 2009;68(5):515-24.
2009: Lutgarde Serneels; Jérôme Van Biervliet; Katleen Craessaerts; Tim Dejaegere; Katrien Horré; Tine Van Houtvin; Hermann Esselmann; Sabine Paul; Martin K Schäfer; Oksana Berezovska; Bradley T Hyman; Ben Sprangers; Raf Sciot; Lieve Moons; Mathias Jucker; Zhixiang Yang; Patrick May; Eric Karran; Jens Wiltfang; Rudi D'Hooge; Bart De Strooper
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Science (New York, N.Y.) 2009;324(5927):639-42.
2009: Nikolaus R McFarland; Jeng-Shin Lee; Bradley T Hyman; Pamela J McLean
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system.
Journal of neurochemistry 2009;109(3):838-45.
2009: Alice Lu; Mikko Hiltunen; Donna M Romano; Hilkka Soininen; Bradley T Hyman; Lars Bertram; Rudolph E Tanzi
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Hyang-Sook Hoe; Zhanyan Fu; Alexandra Makarova; Ji-Yun Lee; Congyi Lu; Li Feng; Ahdeah Pajoohesh-Ganji; Yasuji Matsuoka; Bradley T Hyman; Michael D Ehlers; Stefano Vicini; Daniel T S Pak; G. William Rebeck
The effects of amyloid precursor protein on postsynaptic composition and activity.
The Journal of biological chemistry 2009;284(13):8495-506.
2009: Robert M Koffie; Melanie Meyer-Luehmann; Tadafumi Hashimoto; Kenneth W Adams; Matthew L Mielke; Monica Garcia-Alloza; Kristina D Micheva; Stephen J Smith; M Leo Kim; Virginia M-Y Lee; Bradley T Hyman; Tara L Spires-Jones
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):4012-7.
2009: Tara L Spires-Jones; William H Stoothoff; Alix de Calignon; Phillip B Jones; Bradley T Hyman
Tau pathophysiology in neurodegeneration: a tangled issue.
Trends in neurosciences 2009;32(3):150-9.
2009: R S Desikan; Howard Cabral; Bruce Fischl; Charles R G Guttmann; Deborah Blacker; Bradley T Hyman; Marilyn S Albert; Ronald J Killiany
Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease.
AJNR. American journal of neuroradiology 2009;30(3):532-8.
2009: Bradford C Dickerson; Akram Bakkour; David H Salat; Eric Feczko; Jenni Pacheco; Douglas N Greve; Fran Grodstein; Christopher I Wright; Deborah Blacker; H Diana Rosas; Reisa Sperling; Alireza Atri; John H Growdon; Bradley T Hyman; John C Morris; Bruce Fischl; Randy L Buckner
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals.
Cerebral cortex (New York, N.Y. : 1991) 2009;19(3):497-510.
2009: Kishore V Kuchibhotla; Carli R Lattarulo; Bradley T Hyman; Brian J Bacskai
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice.
Science (New York, N.Y.) 2009;323(5918):1211-5.
2009: Robert Spoelgen; K W Adams; M Koker; A V Thomas; Olav M Andersen; P J Hallett; K K Bercury; Daniel Joyner; M Deng; W H Stoothoff; Dudley K Strickland; T E Willnow; Bradley T Hyman
Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.
Neuroscience 2009;158(4):1460-8.
2009: Tara L Spires-Jones; Matthew L Mielke; Anete Rozkalne; Melanie Meyer-Luehmann; Alix de Calignon; Brian J Bacskai; Dale Schenk; Bradley T Hyman
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.
Neurobiology of disease 2009;33(2):213-20.
2009: A Viswanathan; S Raj; Steven M Greenberg; Meir J Stampfer; S Campbell; Bradley T Hyman; Michael C Irizarry
Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial.
Neurology 2009;72(3):268-72.
2009: Lena Skoglund; Sofie Ingvast; Toshifumi Matsui; Stefanie H Freeman; Matthew P Frosch; Rosemarie Brundin; Vilmantas Giedraitis; John H Growdon; Bradley T Hyman; Lars Lannfelt; Martin Ingelsson; Anna Glaser
No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration.
Dementia and geriatric cognitive disorders 2009;28(5):471-5.
2009: Kengo Uemura; Christina M Lill; Xuejing Li; Jessica A Peters; Alexander Ivanov; Zhanyun Fan; Bart DeStrooper; Brian J Bacskai; Bradley T Hyman; Oksana Berezovska
Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.
PloS one 2009;4(11):e7893.
2009: Tiago Outeiro; Jochen Klucken; Kathryn Bercury; Julie Tetzlaff; Preeti Putcha; Luis M A Oliveira; Alexandre Quintas; Pamela J McLean; Bradley T Hyman
Dopamine-induced conformational changes in alpha-synuclein.
PloS one 2009;4(9):e6906.
2009: Elin S Blom; Vilmantas Giedraitis; Henrik Zetterberg; Hiroaki Fukumoto; Kaj Blennow; Bradley T Hyman; Michael C Irizarry; Lars-Olof Wahlund; Lars Lannfelt; Martin Ingelsson
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.
Dementia and geriatric cognitive disorders 2009;27(5):458-64.
2009: Monica Garcia-Alloza; Meenakshi Subramanian; Diana Thyssen; Laura A Borrelli; Abdul Fauq; Pritam Das; todd golde; Bradley T Hyman; Brian J Bacskai
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.
Molecular neurodegeneration 2009;4():19.
2009: Olivia I Okereke; Weiming Xia; Michael C Irizarry; Xiaoyan Sun; Wei Q Qiu; Anne M Fagan; Pankaj D Mehta; Bradley T Hyman; Dennis J Selkoe; Francine Grodstein
Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Journal of Alzheimer's disease : JAD 2009;16(2):277-85.
2009: Kengo Uemura; Christina M Lill; Mary Banks; Megumi Asada; Nobuhisa Aoyagi; Koichi Ando; Masakazu Kubota; Takeshi Kihara; Takaaki Nishimoto; Hachiro Sugimoto; Ryosuke Takahashi; Bradley T Hyman; Shun Shimohama; Oksana Berezovska; Ayae Kinoshita
N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.
Journal of neurochemistry 2009;108(2):350-60.
2009: Stefanie H Freeman; Bradley T Hyman; Katherine B Sims; E T Hedley-Whyte; Arastoo Vossough; Matthew P Frosch; Jeremy D Schmahmann
Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations.
Brain pathology (Zurich, Switzerland) 2009;19(1):39-47.
2008: Jessica Koenigsknecht-Talboo; Melanie Meyer-Luehmann; Maia Parsadanian; Monica Garcia-Alloza; Mary Beth Finn; Bradley T Hyman; Brian J Bacskai; David M Holtzman
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14156-64.
2008: Asim K Mandal; Phillip B Jones; Angela M Bair; Peter Christmas; Douglas Miller; Ting-ting D Yamin; Douglas Wisniewski; John Menke; Jilly F Evans; Bradley T Hyman; Brian J Bacskai; Mei Chen; David M Lee; Boris Nikolic; Roy J Soberman
The nuclear membrane organization of leukotriene synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20434-9.
2008: Stefanie H Freeman; Ruth Kandel; Luis Cruz; Anete Rozkalne; Kathy Newell; Matthew P Frosch; E Tessa Hedley-Whyte; Joseph J Locascio; Lewis A Lipsitz; Bradley T Hyman
Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease.
Journal of neuropathology and experimental neurology 2008;67(12):1205-12.
2008: William H Stoothoff; Brian J Bacskai; Bradley T Hyman
Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons.
Journal of biomedical optics 2008;13(6):064039.
2008: Paul O'Callaghan; Elina Sandwall; Jin-Ping Li; Hong Yu; Rivka Ravid; Zhi-Zhong Guan; Toin H van Kuppevelt; Lars N G Nilsson; Martin Ingelsson; Bradley T Hyman; Hannu Kalimo; Ulf Lindahl; Lars Lannfelt; Xiao Zhang
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
Brain pathology (Zurich, Switzerland) 2008;18(4):548-61.
2008: J Sundelöf; Johan Arnlöv; Erik Ingelsson; Johan Sundström; Samar Basu; Björn Zethelius; Anders Larsson; Michael C Irizarry; Vilmantas Giedraitis; E Rönnemaa; M Degerman-Gunnarsson; Bradley T Hyman; Hans Basun; Lena Kilander; Lars Lannfelt
Serum cystatin C and the risk of Alzheimer disease in elderly men.
Neurology 2008;71(14):1072-9.
2008: S N Gomperts; Dorene M Rentz; E Moran; John A Becker; Joseph J Locascio; William E Klunk; Chester A Mathis; David R Elmaleh; T Shoup; Alan J Fischman; Bradley T Hyman; John H Growdon; Keith A Johnson
Imaging amyloid deposition in Lewy body diseases.
Neurology 2008;71(12):903-10.
2008: Alexandra Makarova; Kathryn K Bercury; Kenneth W Adams; Daniel Joyner; Meihua Deng; Robert Spoelgen; Mirjam Koker; Dudley K Strickland; Bradley T Hyman
The LDL receptor-related protein can form homo-dimers in neuronal cells.
Neuroscience letters 2008;442(2):91-5.
2008: R S Desikan; Bruce Fischl; H J Cabral; T L Kemper; Charles R G Guttmann; Deborah Blacker; Bradley T Hyman; Marilyn S Albert; Ronald J Killiany
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD.
Neurology 2008;71(11):819-25.
2008: Kishore V Kuchibhotla; Samuel T Goldman; Carli R Lattarulo; Hai-Yan Wu; Bradley T Hyman; Brian J Bacskai
Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks.
Neuron 2008;59(2):214-25.
2008: Phill B Jones; Hwa Kyoung Shin; David A Boas; Bradley T Hyman; Michael A Moskowitz; Cenk Ayata; Andrew K Dunn
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia.
Journal of biomedical optics 2008;13(4):044007.
2008: Joshua Steinerman; Michael C Irizarry; Nikolaos Scarmeas; Susan Raju; Jason Brandt; Marilyn S Albert; Deborah Blacker; Bradley T Hyman; Yaakov Stern
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study.
Archives of neurology 2008;65(7):906-12.
2008: Julie E Tetzlaff; Preeti Putcha; Tiago Outeiro; Alexander Ivanov; Oksana Berezovska; Bradley T Hyman; Pamela J McLean
CHIP targets toxic alpha-Synuclein oligomers for degradation.
The Journal of biological chemistry 2008;283(26):17962-8.
2008: Joseph J Locascio; Hiroaki Fukumoto; Liang Yap; Teodoro Bottiglieri; John H Growdon; Bradley T Hyman; Michael C Irizarry
Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease.
Archives of neurology 2008;65(6):776-85.
2008: ZAVEN KHACHATURIAN; Ronald C. Petersen; S Gauthier; Neil Buckholtz; Jody Corey-Bloom; Bill Evans; Howard Fillit; Norman Foster; Barry Greenberg; Michael Grundman; Mary Sano; James Simpkins; Lon S Schneider; Michael Weiner; Douglas Galasko; Bradley T Hyman; Lew Kuller; Dale Schenk; Stephen Snyder; Ronald Thomas; Mark H Tuszynski; Bruno Vellas; Richard J Wurtman; Peter J Snyder; Richard A Frank; Marilyn S Albert; Rachelle S Doody; Steven H Ferris; Jeffrey A Kaye; Edward H Koo; Marcelle Morrison-Bogorad; Barry Reisberg; David P Salmon; Sid Gilman; Richard C Mohs; Paul S Aisen; John C S Breitner; Jeffrey L Cummings; Claudia Kawas; Creighton Phelps; Judes Poirier; Marwan Sabbagh; Jacques Touchon; Ara Khachaturian; Lisa J Bain
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(3):156-63.
2008: Anne V Thomas; Oksana Berezovska; Bradley T Hyman; Christine A F Von Arnim
Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells.
Methods (San Diego, Calif.) 2008;44(4):299-303.
2008: Hyang-Sook Hoe; S Sakura Minami; Alexandra Makarova; Jiyeon Lee; Bradley T Hyman; Yasuji Matsuoka; G. William Rebeck
Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
The Journal of biological chemistry 2008;283(10):6288-99.
2008: Talene A Yacoubian; Ippolita Cantuti-Castelvetri; Bérengère Bouzou; Georgios Asteris; Pamela J McLean; Bradley T Hyman; David G Standaert
Transcriptional dysregulation in a transgenic model of Parkinson disease.
Neurobiology of disease 2008;29(3):515-28.
2008: Melanie Meyer-Luehmann; Tara L Spires-Jones; Claudia Prada; Monica Garcia-Alloza; Alix de Calignon; Anete Rozkalne; Jessica Koenigsknecht-Talboo; David M Holtzman; Brian J Bacskai; Bradley T Hyman
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Nature 2008;451(7179):720-4.
2008: Johan Sundelöf; Vilmantas Giedraitis; Michael C Irizarry; Johan Sundström; Erik Ingelsson; Elina Rönnemaa; Johan Arnlöv; Malin Degerman Gunnarsson; Bradley T Hyman; Hans Basun; Martin Ingelsson; Lars Lannfelt; Lena Kilander
Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study.
Archives of neurology 2008;65(2):256-63.
2008: Tara L Spires-Jones; Alix de Calignon; Toshifumi Matsui; Cindy Zehr; Rose Pitstick; Hai-Yan Wu; Jennifer D Osetek; Phillip B Jones; Brian J Bacskai; Mel B Feany; George A Carlson; Karen K. Hsiao Ashe; Jada Lewis; Bradley T Hyman
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(4):862-7.
2008: Francine Grodstein; Marieke van Oijen; Michael C Irizarry; H Diana Rosas; Bradley T Hyman; John H Growdon; Immaculata DeVivo
Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study.
PloS one 2008;3(2):e1590.
2008: Bradley T Hyman
In reply to Zou et al. "New amyloid plaques or a game of hide-and-seek?".
International journal of biological sciences 2008;4(4):245.
2008: Teresa Gomez-Isla; Tara Spires; Alix De Calignon; Bradley T Hyman
Neuropathology of Alzheimer's disease.
Handbook of clinical neurology 2008;89():233-43.
2008: Tiago Outeiro; Preeti Putcha; Julie E Tetzlaff; Robert Spoelgen; Mirjam Koker; Filipe Carvalho; Bradley T Hyman; Pamela J McLean
Formation of toxic oligomeric alpha-synuclein species in living cells.
PloS one 2008;3(4):e1867.
2008: Phillip B Jones; Aneta Rozkalne; Melanie Meyer-Luehmann; Tara L Spires-Jones; Alexandra Makarova; Anand T N Kumar; Oksana Berezovska; Brian J Bacskai; Bradley T Hyman
Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.
Journal of biomedical optics 2008;13(1):014008.
2008: Stefanie H Freeman; Tara Spires-Jones; Bradley T Hyman; John H Growdon; Matthew P Frosch
TAR-DNA binding protein 43 in Pick disease.
Journal of neuropathology and experimental neurology 2008;67(1):62-7.
2007: Bradford C Dickerson; Reisa Sperling; Bradley T Hyman; Marilyn S Albert; Deborah Blacker
Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment.
Archives of general psychiatry 2007;64(12):1443-50.
2007: Monica Garcia-Alloza; Brian J Ferrara; Sarah A Dodwell; Gregory A Hickey; Bradley T Hyman; Brian J Bacskai
A limited role for microglia in antibody mediated plaque clearance in APP mice.
Neurobiology of disease 2007;28(3):286-92.
2007: Tom N Grammatopoulos; Tiago Outeiro; Bradley T Hyman; David G Standaert
Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro.
Biochemical and biophysical research communications 2007;363(3):846-51.
2007: Vilmantas Giedraitis; Johan Sundelöf; Michael C Irizarry; Nina Gårevik; Bradley T Hyman; Lars-Olof Wahlund; Martin Ingelsson; Lars Lannfelt
The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease.
Neuroscience letters 2007;427(3):127-31.
2007: Cintia Conrad; Jun Zhu; Cintia Conrad; David Schoenfeld; Zhide Fang; Martin Ingelsson; Stefan Stamm; George Church; Bradley T Hyman
Single molecule profiling of tau gene expression in Alzheimer's disease.
Journal of neurochemistry 2007;103(3):1228-36.
2007: Martin Ingelsson; Karunya Ramasamy; Carsten Russ; Stefanie H Freeman; Jennifer Orne; Susan Raju; Toshifumi Matsui; John H Growdon; Matthew P Frosch; Bernardino Ghetti; Robert H Brown; Michael C Irizarry; Bradley T Hyman
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains.
Acta neuropathologica 2007;114(5):471-9.
2007: Tara L Spires-Jones; Melanie Meyer-Luehmann; Jennifer D Osetek; Phillip B Jones; Edward A Stern; Brian J Bacskai; Bradley T Hyman
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.
The American journal of pathology 2007;171(4):1304-11.
2007: Hwa Kyoung Shin; Phillip B Jones; Monica Garcia-Alloza; Laura Borrelli; Steven M Greenberg; Brian J Bacskai; Matthew P Frosch; Bradley T Hyman; Michael A Moskowitz; Cenk Ayata
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
Brain : a journal of neurology 2007;130(Pt 9):2310-9.
2007: Toshifumi Matsui; Martin Ingelsson; Hiroaki Fukumoto; Karunya Ramasamy; Hisanori Kowa; Matthew P Frosch; Michael C Irizarry; Bradley T Hyman
Expression of APP pathway mRNAs and proteins in Alzheimer's disease.
Brain research 2007;1161():116-23.
2007: Monica Garcia-Alloza; L A Borrelli; A Rozkalne; Bradley T Hyman; Brian J Bacskai
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.
Journal of neurochemistry 2007;102(4):1095-104.
2007: Tiago Outeiro; Eirene Kontopoulos; Stephen M Altmann; Irina Kufareva; Katherine E Strathearn; Allison M Amore; Catherine B Volk; Michele M Maxwell; Jean-Christophe Rochet; Pamela J McLean; Anne B Young; Ruben Abagyan; Mel B Feany; Bradley T Hyman; Aleksey G Kazantsev
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Science (New York, N.Y.) 2007;317(5837):516-9.
2007: Tiago Outeiro; Tom N Grammatopoulos; Stephen M Altmann; Allison M Amore; David G Standaert; Bradley T Hyman; Aleksey G Kazantsev
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
Biochemical and biophysical research communications 2007;357(3):596-602.
2007: Tara L Spires; Bradley T Hyman
Spine tingling polymorphisms--is apolipoprotein E involved in dendritic shape and plasticity?
Neurobiology of aging 2007;28(5):687-8; discussion 704-6.
2007: Stefanie H Freeman; Susan Raju; Bradley T Hyman; Matthew P Frosch; Michael C Irizarry
Plasma Abeta levels do not reflect brain Abeta levels.
Journal of neuropathology and experimental neurology 2007;66(4):264-71.
2007: Minji Kim; Louis B Hersh; Malcolm Leissring; Martin Ingelsson; Toshifumi Matsui; Wesley Farris; Alice Lu; Bradley T Hyman; Dennis J Selkoe; Lars Bertram; Rudolph E Tanzi
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: Brian J Bacskai; Matthew P Frosch; Stefanie H Freeman; Scott B Raymond; Jean C Augustinack; Keith A Johnson; Michael C Irizarry; William E Klunk; Chester A Mathis; Steven T DeKosky; Steven M Greenberg; Bradley T Hyman; John H Growdon
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology 2007;64(3):431-4.
2007: Jessie L St Martin; Jochen Klucken; Tiago Outeiro; Paul Nguyen; Christine Keller-McGandy; Ippolita Cantuti-Castelvetri; Tom N Grammatopoulos; David G Standaert; Bradley T Hyman; Pamela J McLean
Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
Journal of neurochemistry 2007;100(6):1449-57.
2007: Tudor A Fulga; Ilan Elson-Schwab; Vikram Khurana; Michelle L Steinhilb; Tara L Spires; Bradley T Hyman; Mel B Feany
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
Nature cell biology 2007;9(2):139-48.
2007: Michael C Irizarry; Y Yao; Bradley T Hyman; John H Growdon; Domenico Pratico'
Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease.
Neuro-degenerative diseases 2007;4(6):403-5.
2006: Tiago Outeiro; Jochen Klucken; Katherine E Strathearn; Fang Liu; Paul Nguyen; Jean-Christophe Rochet; Bradley T Hyman; Pamela J McLean
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.
Biochemical and biophysical research communications 2006;351(3):631-8.
2006: Monica Garcia-Alloza; Sarah A Dodwell; Melanie Meyer-Luehmann; Bradley T Hyman; Brian J Bacskai
Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model.
Journal of neuropathology and experimental neurology 2006;65(11):1082-9.
2006: Mikko Hiltunen; Alice Lu; Anne V Thomas; Donna M Romano; Minji Kim; Phill B Jones; Zhongcong Xie; Maria Z Kounnas; Steven L Wagner; Oksana Berezovska; Bradley T Hyman; Giuseppina Tesco; Lars Bertram; Rudolph E Tanzi
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry 2006;281(43):32240-53.
2006: Ithan D Peltan; Anne V Thomas; Irina Mikhailenko; Dudley K Strickland; Bradley T Hyman; Christine A F Von Arnim
Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons.
Biochemical and biophysical research communications 2006;349(1):24-30.
2006: Bradley T Hyman
The natural history of Alzheimer disease dissected through multiphoton imaging of transgenic mice.
Alzheimer disease and associated disorders 2006;20(4):206-9.
2006: Jochen Klucken; Tiago Outeiro; Paul Nguyen; Pamela J McLean; Bradley T Hyman
Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2050-7.
2006: Martin Ingelsson; Karunya Ramasamy; Ippolita Cantuti-Castelvetri; Lena Skoglund; Toshifumi Matsui; Jennifer Orne; Hisanori Kowa; Susan Raju; Charles R Vanderburg; Jean C Augustinack; Rohan de Silva; Andrew J Lees; Lars Lannfelt; John H Growdon; Matthew P Frosch; David G Standaert; Michael C Irizarry; Bradley T Hyman
No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain.
Acta neuropathologica 2006;112(4):439-49.
2006: Christine A F Von Arnim; Robert Spoelgen; Ithan D Peltan; Meihua Deng; Stephanie Courchesne; Mirjam Koker; Toshifumi Matsui; Hisanori Kowa; Stefan F Lichtenthaler; Michael C Irizarry; Bradley T Hyman
GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):9913-22.
2006: Sanja Sever; Jesse Skoch; Sherri L Newmyer; Rajesh Ramachandran; David Ko; Mary McKee; Richard Bouley; Dennis A Ausiello; Bradley T Hyman; Brian J Bacskai
Physical and functional connection between auxilin and dynamin during endocytosis.
The EMBO journal 2006;25(18):4163-74.
2006: Anne V Thomas; Lauren Herl; Robert Spoelgen; Mikko Hiltunen; Phill B Jones; Rudolph E Tanzi; Bradley T Hyman; Oksana Berezovska
Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.
The Journal of biological chemistry 2006;281(36):26400-7.
2006: Phill B Jones; Lauren Herl; Oksana Berezovska; Anand T N Kumar; Brian J Bacskai; Bradley T Hyman
Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays.
Journal of biomedical optics 2006;11(5):054024.
2006: Ying Xiong; Chunzhang Cao; Alexandra Makarova; Bradley T Hyman; Li Zhang
Mac-1 promotes FcgammaRIIA-dependent cell spreading and migration on immune complexes.
Biochemistry 2006;45(29):8721-31.
2006: Bradley T Hyman; John H Growdon
Can the immune system fight Alzheimer disease?
Nature medicine 2006;12(7):755-6; discussion 756.
2006: Rahul S Desikan; Florent Ségonne; Bruce Fischl; Brian T Quinn; Bradford C Dickerson; Deborah Blacker; Randy L Buckner; Anders Dale; R Paul Maguire; Bradley T Hyman; Marilyn S Albert; Ronald J Killiany
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.
NeuroImage 2006;31(3):968-80.
2006: Chunzhang Cao; Daniel Lawrence; Yang Li; Christine A F Von Arnim; Joachim Herz; Enming Joseph Su; Alexandra Makarova; Bradley T Hyman; Dudley K Strickland; Li Zhang
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.
The EMBO journal 2006;25(9):1860-70.
2006: Toshifumi Matsui; Karunya Ramasamy; Martin Ingelsson; Hiroaki Fukumoto; Cintia Conrad; Matthew P Frosch; Michael C Irizarry; Junying Yuan; Bradley T Hyman
Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.
Journal of neuropathology and experimental neurology 2006;65(5):508-15.
2006: Tara L Spires; Jennifer Orne; Karen SantaCruz; Rose Pitstick; George A Carlson; Karen K. Hsiao Ashe; Bradley T Hyman
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.
The American journal of pathology 2006;168(5):1598-607.
2006: Penelope J Hallett; Robert Spoelgen; Bradley T Hyman; David G Standaert; Anthone W Dunah
Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4690-700.
2006: Ruth A Bodner; Tiago Outeiro; Stephen M Altmann; Michele M Maxwell; Stephanie H Cho; Bradley T Hyman; Pamela J McLean; Anne B Young; David E Housman; Aleksey G Kazantsev
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4246-51.
2006: Olav M Andersen; Vanessa Schmidt; Robert Spoelgen; Jørgen Gliemann; Joachim Behlke; Denise Galatis; William J McKinstry; Michael W Parker; Colin L Masters; Bradley T Hyman; Roberto Cappai; Thomas E Willnow
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Biochemistry 2006;45(8):2618-28.
2006: Lauren Herl; Alberto Lleo; Anne V Thomas; Andrew C Nyborg; Karen Jansen; todd golde; Bradley T Hyman; Oksana Berezovska
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.
Biochemical and biophysical research communications 2006;340(2):668-74.
2006: Jochen Klucken; Martin Ingelsson; Youngah Shin; Michael C Irizarry; E Tessa Hedley-Whyte; M Frosch; John H Growdon; Pamela J McLean; Bradley T Hyman
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.
Acta neuropathologica 2006;111(2):101-8.
2006: Roee Holtzer; Michael C Irizarry; Jody Sanders; Bradley T Hyman; Domonick J Wegesin; Aliza Riba; Jason Brandt; Marilyn S Albert; Yaakov Stern
Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease.
Archives of neurology 2006;63(2):226-30.
2006: Robert Spoelgen; Christine A F Von Arnim; Anne V Thomas; Ithan D Peltan; Mirjam Koker; Amy Deng; Michael C Irizarry; Olav M Andersen; Thomas E Willnow; Bradley T Hyman
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):418-28.
2006: Elissa M Robbins; Rebecca A Betensky; Sarah B Domnitz; Susan M Purcell; Monica Garcia-Alloza; Charles Greenberg; G. William Rebeck; Bradley T Hyman; Steven M Greenberg; Matthew P Frosch; Brian J Bacskai
Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):365-71.
2006: Andrew C Nyborg; Lauren Herl; Oksana Berezovska; Anne V Thomas; Thomas B Ladd; Karen Jansen; Bradley T Hyman; todd golde
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Molecular neurodegeneration 2006;1():16.
2006: Jesse Skoch; Bradley T Hyman; Brian J Bacskai
Preclinical characterization of amyloid imaging probes with multiphoton microscopy.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):401-7.
2006: M L D Broekman; L A Comer; Bradley T Hyman; Miguel Sena-Esteves
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain.
Neuroscience 2006;138(2):501-10.
2005: Ippolita Cantuti-Castelvetri; Jochen Klucken; Martin Ingelsson; Karunya Ramasamy; Pamela J McLean; Matthew P Frosch; Bradley T Hyman; David G Standaert
Alpha-synuclein and chaperones in dementia with Lewy bodies.
Journal of neuropathology and experimental neurology 2005;64(12):1058-66.
2005: Zhongmin Xiang; Evgueni E Nesterov; Jesse Skoch; Tong Lin; Bradley T Hyman; Timothy M Swager; Brian J Bacskai; Steven A Reeves
Detection of myelination using a novel histological probe.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(12):1511-6.
2005: Michael C Irizarry; Mahmut Gurol; S Raju; Ramon Diaz-Arrastia; Joseph J Locascio; Marsha Tennis; Bradley T Hyman; John H Growdon; Steven M Greenberg; Teodoro Bottiglieri
Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease.
Neurology 2005;65(9):1402-8.
2005: Giuseppina Tesco; Andrea Ginestroni; Mikko Hiltunen; Minji Kim; Georgia Dolios; Bradley T Hyman; Rong Wang; Oksana Berezovska; Rudolph E Tanzi
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
Journal of neurochemistry 2005;95(2):446-56.
2005: Olav M Andersen; Juliane Reiche; Vanessa Schmidt; Michael Gotthardt; Robert Spoelgen; Joachim Behlke; Christine A F Von Arnim; Tilman Breiderhoff; Pernille Jansen; Xin Wu; Kelly R Bales; Roberto Cappai; Colin L Masters; Jørgen Gliemann; Elliott J Mufson; Bradley T Hyman; Steven M Paul; Anders Nykjaer; Thomas E Willnow
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13461-6.
2005: Young Ho Koh; Christine A F Von Arnim; Bradley T Hyman; Rudolph E Tanzi; Giuseppina Tesco
BACE is degraded via the lysosomal pathway.
The Journal of biological chemistry 2005;280(37):32499-504.
2005: Evgueni E Nesterov; Jesse Skoch; Bradley T Hyman; William E Klunk; Brian J Bacskai; Timothy M Swager
In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
Angewandte Chemie (International ed. in English) 2005;44(34):5452-6.
2005: Tara L Spires; Melanie Meyer-Luehmann; Edward A Stern; Pamela J McLean; Jesse Skoch; Paul T Nguyen; Brian J Bacskai; Bradley T Hyman
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(31):7278-87.
2005: Jose Ruiz; Diana Kouiavskaia; Molly Migliorini; Susan Robinson; Evgueni L Saenko; Natalia V Gorlatova; Donghua Li; Daniel Lawrence; Bradley T Hyman; Karl H Weisgraber; Dudley K Strickland
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.
Journal of lipid research 2005;46(8):1721-31.
2005: Alberto Lleó; Elaine Waldron; Christine A F Von Arnim; Lauren Herl; Michelle M Tangredi; Ithan D Peltan; Dudley K Strickland; Edward H Koo; Bradley T Hyman; Claus U Pietrzik; Oksana Berezovska
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
The Journal of biological chemistry 2005;280(29):27303-9.
2005: Karen SantaCruz; Jada Lewis; Tara L Spires; J Paulson; Linda Kotilinek; Martin Ingelsson; A Guimaraes; Michael DeTure; M Ramsden; Eileen McGowan; Colleen Forster; Mei Yue; Jennifer Orne; Christopher Janus; Ami Mariash; M Kuskowski; Bradley T Hyman; Michael Hutton; Karen K. Hsiao Ashe
Tau suppression in a neurodegenerative mouse model improves memory function.
Science (New York, N.Y.) 2005;309(5733):476-81.
2005: Tara L Spires; Bradley T Hyman
Transgenic models of Alzheimer's disease: learning from animals.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(3):423-37.
2005: Sarah B Domnitz; Elissa M Robbins; Alex W Hoang; Monica Garcia-Alloza; Bradley T Hyman; G. William Rebeck; Steven M Greenberg; Brian J Bacskai; Matthew P Frosch
Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease.
Journal of neuropathology and experimental neurology 2005;64(7):588-94.
2005: Jung Lee; Hiroaki Fukumoto; Jennifer Orne; Jochen Klucken; Susan Raju; Charles R Vanderburg; Michael C Irizarry; Bradley T Hyman; Martin Ingelsson
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.
Experimental neurology 2005;194(1):91-6.
2005: Youngah Shin; Jochen Klucken; Winston Patterson; Bradley T Hyman; Pamela J McLean
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.
The Journal of biological chemistry 2005;280(25):23727-34.
2005: Christine A F Von Arnim; Ayae Kinoshita; Ithan D Peltan; Michelle M Tangredi; Lauren Herl; Bonny M Lee; Robert Spoelgen; Tammy T Hshieh; Sripriya Ranganathan; Frances D Battey; Chun-Xiang Liu; Brian J Bacskai; Sanja Sever; Michael C Irizarry; Dudley K Strickland; Bradley T Hyman
The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
The Journal of biological chemistry 2005;280(18):17777-85.
2005: Robert D. Moir; Katya A Tseitlin; Stephanie Soscia; Bradley T Hyman; Michael C Irizarry; Rudolph E Tanzi
Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.
The Journal of biological chemistry 2005;280(17):17458-63.
2005: Oksana Berezovska; Alberto Lleo; Lauren Herl; Matthew P Frosch; Edward A Stern; Brian J Bacskai; Bradley T Hyman
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(11):3009-17.
2005: Lars Bertram; Mikko Hiltunen; Michele Parkinson; Martin Ingelsson; Christoph Lange; Karunya Ramasamy; Kristina Mullin; Rashmi Menon; Andrew J Sampson; Monica Hsiao; Kathryn J Elliott; Gonul Velicelebi; Thomas J Moscarillo; Bradley T Hyman; Steven L Wagner; K David Becker; Deborah Blacker; Rudolph E Tanzi
Family-based association between Alzheimer's disease and variants in UBQLN1.
The New England journal of medicine 2005;352(9):884-94.
2005: Robert P Brendza; Brian J Bacskai; John R Cirrito; Kelly Simmons; Jesse Skoch; William E Klunk; Chester A Mathis; Kelly R Bales; Steven M Paul; Bradley T Hyman; David M Holtzman
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
The Journal of clinical investigation 2005;115(2):428-33.
2005: Bradley T Hyman; Jean C Augustinack; Martin Ingelsson
Transcriptional and conformational changes of the tau molecule in Alzheimer's disease.
Biochimica et biophysica acta 2005;1739(2-3):150-7.
2005: Jesse Skoch; Gregory A Hickey; Stephen T Kajdasz; Bradley T Hyman; Brian J Bacskai
In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy.
Methods in molecular biology (Clifton, N.J.) 2005;299():349-63.
2005: Jesse Skoch; Andrew Dunn; Bradley T Hyman; Brian J Bacskai
Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology.
Journal of biomedical optics 2005;10(1):11007.
2004: Jochen Klucken; Youngah Shin; Bradley T Hyman; Pamela J McLean
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.
Biochemical and biophysical research communications 2004;325(1):367-73.
2004: Christine A F Von Arnim; Michelle M Tangredi; Ithan D Peltan; Bonny M Lee; Michael C Irizarry; Ayae Kinoshita; Bradley T Hyman
Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
Journal of cell science 2004;117(Pt 22):5437-45.
2004: Alberto Lleó; Oksana Berezovska; Lauren Herl; Susan Raju; Amy Deng; Brian J Bacskai; Matthew P Frosch; Michael C Irizarry; Bradley T Hyman
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Nature medicine 2004;10(10):1065-6.
2004: Sripriya Ranganathan; Chun-Xiang Liu; Molly Migliorini; Christine A F Von Arnim; Ithan D Peltan; Irina Mikhailenko; Bradley T Hyman; Dudley K Strickland
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.
The Journal of biological chemistry 2004;279(39):40536-44.
2004: Martin Ingelsson; Jennifer Jesneck; Michael C Irizarry; Bradley T Hyman; G. William Rebeck
Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease.
Neuroscience letters 2004;367(2):228-31.
2004: Michael C Irizarry; Amy Deng; Alberto Lleo; Oksana Berezovska; Christine A F Von Arnim; Matthew D Martin-Rehrmann; Arlene M Manelli; Mary Jo Ladu; Bradley T Hyman; G. William Rebeck
Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Journal of neurochemistry 2004;90(5):1132-43.
2004: Pamela J McLean; Jochen Klucken; Youngah Shin; Bradley T Hyman
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.
Biochemical and biophysical research communications 2004;321(3):665-9.
2004: Zhihua Qiu; Bradley T Hyman; G. William Rebeck
Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons.
The Journal of biological chemistry 2004;279(33):34948-56.
2004: Pattie Green; Armando J Mendez; Jason S Jacob; Jan R Crowley; Whit Growdon; Bradley T Hyman; Jay W Heinecke
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease.
Journal of neurochemistry 2004;90(3):724-33.
2004: Piera Pasinelli; Mary Elizabeth Belford; Niall Lennon; Brian J Bacskai; Bradley T Hyman; Davide Trotti; Robert H Brown
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.
Neuron 2004;43(1):19-30.
2004: Jochen Klucken; Youngah Shin; Eliezer Masliah; Bradley T Hyman; Pamela J McLean
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.
The Journal of biological chemistry 2004;279(24):25497-502.
2004: Edward A Stern; Brian J Bacskai; Gregory A Hickey; Frank J Attenello; Julianne A Lombardo; Bradley T Hyman
Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4535-40.
2004: Asim K Mandal; Jesse Skoch; Brian J Bacskai; Bradley T Hyman; Peter Christmas; Douglas Miller; Ting-ting D Yamin; Shihua Xu; Douglas Wisniewski; Jilly F Evans; Roy J Soberman
The membrane organization of leukotriene synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6587-92.
2004: Martin Ingelsson; Hiroaki Fukumoto; KL Newell; John H Growdon; E Tessa Hedley-Whyte; Matthew P Frosch; Marilyn S Albert; Bradley T Hyman; Michael C Irizarry
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain.
Neurology 2004;62(6):925-31.
2004: Alberto Lleó; Oksana Berezovska; John H Growdon; Bradley T Hyman
Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004;12(2):146-56.
2004: Hiroaki Fukumoto; Douglas Rosene; Mark B Moss; Susan Raju; Bradley T Hyman; Michael C Irizarry
Beta-secretase activity increases with aging in human, monkey, and mouse brain.
The American journal of pathology 2004;164(2):719-25.
2004: Tara L Spires; Bradley T Hyman
Neuronal structure is altered by amyloid plaques.
Reviews in the neurosciences 2004;15(4):267-78.
2003: Niall Lennon; Alvin Kho; Brian J Bacskai; Sarah L Perlmutter; Bradley T Hyman; Robert H Brown
Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.
The Journal of biological chemistry 2003;278(50):50466-73.
2003: Alberto Lleó; Oksana Berezovska; Pavan Ramdya; Hiroaki Fukumoto; Susan Raju; Tejal Shah; Bradley T Hyman
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
The Journal of biological chemistry 2003;278(48):47370-5.
2003: Julianne A Lombardo; Edward A Stern; Megan E McLellan; Stephen T Kajdasz; Gregory A Hickey; Brian J Bacskai; Bradley T Hyman
Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(34):10879-83.
2003: Martin Ingelsson; Youngah Shin; Michael C Irizarry; Bradley T Hyman; Lena Lilius; Charlotte Forsell; Caroline Graff
Genotyping of apolipoprotein E: comparative evaluation of different protocols.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2003;Chapter 9():Unit9.14.
2003: William E Klunk; Henry Willy Engler; agneta nordberg; Brian J Bacskai; Yanming Wang; Julie C Price; Mats Bergström; Bradley T Hyman; Bengt Långström; Chester A Mathis
Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography.
Neuroimaging clinics of North America 2003;13(4):781-9, ix.
2003: Pavan Ramdya; Jesse Skoch; Brian J Bacskai; Bradley T Hyman; Oksana Berezovska
Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Journal of neurochemistry 2003;87(4):843-50.
2003: Jochen Klucken; Pamela J McLean; E Gomez-Tortosa; Martin Ingelsson; Bradley T Hyman
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.
Neurochemical research 2003;28(11):1683-91.
2003: Ayae Kinoshita; Tejal Shah; Michelle M Tangredi; Dudley K Strickland; Bradley T Hyman
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
The Journal of biological chemistry 2003;278(42):41182-8.
2003: Brian J Bacskai; Gregory A Hickey; Jesse Skoch; Stephen T Kajdasz; Yanming Wang; Guo-Feng Huang; Chester A Mathis; William E Klunk; Bradley T Hyman
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12462-7.
2003: Chittaranjan Das; Oksana Berezovska; Thekla S Diehl; Cedric Genet; Ilya Buldyrev; Jui-Yi Tsai; Bradley T Hyman; Michael S Wolfe
Designed helical peptides inhibit an intramembrane protease.
Journal of the American Chemical Society 2003;125(39):11794-5.
2003: Hiroaki Fukumoto; Martin Ingelsson; Nina Gårevik; Lars-Olof Wahlund; Nobuyuki Nukina; Yoshio Yaguchi; Masao Shibata; Bradley T Hyman; G. William Rebeck; Michael C Irizarry
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis.
Experimental neurology 2003;183(1):249-53.
2003: Michael C Irizarry; Bradley T Hyman
Brain isoprostanes: a marker of lipid peroxidation and oxidative stress in AD.
Neurology 2003;61(4):436-7.
2003: Ayae Kinoshita; Hiroaki Fukumoto; Tejal Shah; Christa M Whelan; Michael C Irizarry; Bradley T Hyman
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
Journal of cell science 2003;116(Pt 16):3339-46.
2003: Monika Atiya; Bradley T Hyman; Marilyn S Albert; Ronald J Killiany
Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review.
Alzheimer disease and associated disorders 2003;17(3):177-95.
2003: Brian J Bacskai; Jesse Skoch; Gregory A Hickey; Racquel Allen; Bradley T Hyman
Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques.
Journal of biomedical optics 2003;8(3):368-75.
2003: Hiroaki Fukumoto; Marsha Tennis; Joseph J Locascio; Bradley T Hyman; John H Growdon; Michael C Irizarry
Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.
Archives of neurology 2003;60(7):958-64.
2003: Oksana Berezovska; Brian J Bacskai; Bradley T Hyman
Monitoring proteins in intact cells.
Science of aging knowledge environment : SAGE KE 2003;2003(23):PE14.
2003: Daniel A Dombeck; Karl A Kasischke; Harshad D Vishwasrao; Martin Ingelsson; Bradley T Hyman; Watt W Webb
Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7081-6.
2003: Warren R Zipfel; Rebecca M Williams; Richard Christie; Alexander Nikitin; Bradley T Hyman; Watt W Webb
Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7075-80.
2003: Oksana Berezovska; Pavan Ramdya; Jesse Skoch; Michael S Wolfe; Brian J Bacskai; Bradley T Hyman
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4560-6.
2003: Shouyong Peng; Brigita Urbanc; Luis Cruz; Bradley T Hyman; H Eugene Stanley
Neuron recognition by parallel Potts segmentation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3847-52.
2003: Steven M Greenberg; Brian J Bacskai; Bradley T Hyman
Alzheimer disease's double-edged vaccine.
Nature medicine 2003;9(4):389-90.
2003: Megan E McLellan; Stephen T Kajdasz; Bradley T Hyman; Brian J Bacskai
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2212-7.
2003: Teresa Gomez-Isla; Michael C Irizarry; Ami Mariash; Bonnie Cheung; Oscar Soto; Stefanie Schrump; Jesse Sondel; Linda Kotilinek; John Day; Michael A Schwarzschild; Jang-Ho Cha; Kathy Newell; David W Miller; Kenji Uéda; Anne B Young; Bradley T Hyman; Karen K. Hsiao Ashe
Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.
Neurobiology of aging 2003;24(2):245-58.
2003: J D D'Amore; Stephen T Kajdasz; Megan E McLellan; Brian J Bacskai; Edward A Stern; Bradley T Hyman
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Journal of neuropathology and experimental neurology 2003;62(2):137-45.
2003: Zhihua Qiu; keith crutcher; Bradley T Hyman; G. William Rebeck
ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes.
Neuroscience 2003;122(2):291-303.
2003: Craig Micchelli; William P Esler; W Taylor Kimberly; Christine Jack; Oksana Berezovska; Anna Y Kornilova; Bradley T Hyman; Norbert Perrimon; Michael S Wolfe
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):79-81.
2002: Dean A Le; Yongqin Wu; Zhihong Huang; Kohji Matsushita; Nikolaus Plesnila; Jean C Augustinack; Bradley T Hyman; Junying Yuan; Keisuke Kuida; Richard A Flavell; Michael A Moskowitz
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15188-93.
2002: Pamela J McLean; Hibiki Kawamata; Saadat Shariff; Jeffrey W Hewett; Nutan Sharma; Kenji Ueda; Xandra O Breakefield; Bradley T Hyman
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.
Journal of neurochemistry 2002;83(4):846-54.
2002: Brigita Urbanc; Luis Cruz; R Le; J Sanders; Karen K. Hsiao Ashe; karen duff; H Eugene Stanley; Michael C Irizarry; Bradley T Hyman
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):13990-5.
2002: Brian J Bacskai; Bradley T Hyman
Alzheimer's disease: what multiphoton microscopy teaches us.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(5):386-90.
2002: Brian J Bacskai; Stephen T Kajdasz; Megan E McLellan; Dora Games; Peter Seubert; Dale Schenk; Bradley T Hyman
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7873-8.
2002: Leo L Cheng; Kathy Newell; Amy E Mallory; Bradley T Hyman; R Gilberto Gonzalez
Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology.
Magnetic resonance imaging 2002;20(7):527-33.
2002: William E Klunk; Brian J Bacskai; Chester A Mathis; Stephen T Kajdasz; Megan E McLellan; Matthew P Frosch; Manik L Debnath; Daniel P Holt; Yanming Wang; Bradley T Hyman
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Journal of neuropathology and experimental neurology 2002;61(9):797-805.
2002: Hiroaki Fukumoto; Bonnie S Cheung; Bradley T Hyman; Michael C Irizarry
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
Archives of neurology 2002;59(9):1381-9.
2002: Brian J Bacskai; William E Klunk; Chester A Mathis; Bradley T Hyman
Imaging amyloid-beta deposits in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(9):1035-41.
2002: Ayae Kinoshita; Christa M Whelan; Oksana Berezovska; Bradley T Hyman
The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
The Journal of biological chemistry 2002;277(32):28530-6.
2002: Ayae Kinoshita; Christa M Whelan; C J Smith; Oksana Berezovska; Bradley T Hyman
Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
Journal of neurochemistry 2002;82(4):839-47.
2002: Suzanne Y Guénette; Yang Chang; Bradley T Hyman; Rudolph E Tanzi; G. William Rebeck
Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.
Journal of neurochemistry 2002;82(4):755-62.
2002: Linda Kotilinek; Brian J Bacskai; Marcus A Westerman; Takeshi Kawarabayashi; Linda Younkin; Bradley T Hyman; Steven G Younkin; Karen K. Hsiao Ashe
Reversible memory loss in a mouse transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6331-5.
2002: Katrin Arélin; Ayae Kinoshita; Christa M Whelan; Michael C Irizarry; G. William Rebeck; Dudley K Strickland; Bradley T Hyman
LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes.
Brain research. Molecular brain research 2002;104(1):38-46.
2002: Jean C Augustinack; Judith L Sanders; Li-Huei Tsai; Bradley T Hyman
Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.
Journal of neuropathology and experimental neurology 2002;61(6):557-64.
2002: Pamela J McLean; Bradley T Hyman
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.
Neuroscience letters 2002;323(3):219-23.
2002: Michael G Schlossmacher; Matthew P Frosch; Wei Ping Gai; Miguel Medina; Nutan Sharma; Lysia Forno; Tomoyo Ochiishi; Hideki Shimura; Ronit Sharon; Nobutaka Hattori; J William Langston; Yoshikuni Mizuno; Bradley T Hyman; Dennis J Selkoe; Kenneth S Kosik
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology 2002;160(5):1655-67.
2002: Estrella Gómez-Tortosa; Isabel Gonzalo; Kathy Newell; Justo García Yébenes; Paul Vonsattel; Bradley T Hyman
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.
Acta neuropathologica 2002;103(5):495-500.
2002: Zhihua Qiu; Dudley K Strickland; Bradley T Hyman; G. William Rebeck
alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.
The Journal of biological chemistry 2002;277(17):14458-66.
2002: Ronald J Killiany; Bradley T Hyman; T Gomez-Isla; Mark B Moss; R Kikinis; Ferenc A Jolesz; Rudolph E Tanzi; K Jones; Marilyn S Albert
MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
Neurology 2002;58(8):1188-96.
2002: Chester A Mathis; Brian J Bacskai; Stephen T Kajdasz; Megan E McLellan; Matthew P Frosch; Bradley T Hyman; Daniel P Holt; Yanming Wang; Guo-Feng Huang; Manik L Debnath; William E Klunk
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Bioorganic & medicinal chemistry letters 2002;12(3):295-8.
2002: Martin Ingelsson; Bradley T Hyman
Disordered proteins in dementia.
Annals of medicine 2002;34(4):259-71.
2002: Neeha Zaidi; Oksana Berezovska; Eun-Kyoung Choi; Janice Miller; H Chan; Christina Lilliehook; Bradley T Hyman; Joseph Buxbaum; Wilma Wasco
Biochemical and immunocytochemical characterization of calsenilin in mouse brain.
Neuroscience 2002;114(1):247-63.
2002: Kurt Spittaels; Chris Van den Haute; Jo Van Dorpe; Dick Terwel; K Vandezande; Reena Lasrado; K Bruynseels; Michael C Irizarry; Marleen Verhoye; Johan Van Lint; Jackie R Vandenheede; D Ashton; Marc Mercken; R Loos; Bradley T Hyman; Annemie Van der Linden; Hugo Geerts; Fred Van Leuven
Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.
Neuroscience 2002;113(4):797-808.
2002: Jean C Augustinack; Anja Schneider; Eva-Maria Mandelkow; Bradley T Hyman
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.
Acta neuropathologica 2002;103(1):26-35.
2002: MengQi Xia; Bradley T Hyman
GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease?
Journal of neuroimmunology 2002;122(1-2):55-64.
2001: Ayae Kinoshita; Christa M Whelan; C J Smith; Irina Mikhailenko; G. William Rebeck; Dudley K Strickland; Bradley T Hyman
Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(21):8354-61.
2001: Nutan Sharma; Pamela J McLean; Hibiki Kawamata; Michael C Irizarry; Bradley T Hyman
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies.
Acta neuropathologica 2001;102(4):329-34.
2001: Michael C Irizarry; Bradley T Hyman
Alzheimer disease therapeutics.
Journal of neuropathology and experimental neurology 2001;60(10):923-8.
2001: Luigi Puglielli; Genevieve Konopka; E Pack-Chung; Laura A Mackenzie Ingano; Oksana Berezovska; Bradley T Hyman; T Y Chang; Rudolph E Tanzi; Dora M. Kovacs
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Nature cell biology 2001;3(10):905-12.
2001: Oksana Berezovska; Christine Jack; Amy Deng; N Gastineau; G. William Rebeck; Bradley T Hyman
Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
The Journal of biological chemistry 2001;276(32):30018-23.
2001: R Le; Luis Cruz; Brigita Urbanc; RB Knowles; Karen K. Hsiao Ashe; karen duff; Michael C Irizarry; H Eugene Stanley; Bradley T Hyman
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Journal of neuropathology and experimental neurology 2001;60(8):753-8.
2001: Richard Christie; E Kimchi; Stephen T Kajdasz; Brian J Bacskai; Bradley T Hyman
Multiphoton microscopy and amyloid angiopathy.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():48-50.
2001: N Sharma; Jeffrey W Hewett; Laurie J Ozelius; Vijaya Ramesh; Pamela J McLean; Xandra O Breakefield; Bradley T Hyman
A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study.
The American journal of pathology 2001;159(1):339-44.
2001: Bradley T Hyman; C Smith; I Buldyrev; C Whelan; H Brown; Ming-Xin Tang; Richard Mayeux
Autoantibodies to amyloid-beta and Alzheimer's disease.
Annals of neurology 2001;49(6):808-10.
2001: H Chung; MI Brazil; Michael C Irizarry; Bradley T Hyman; Frederick R Maxfield
Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice.
Neuroreport 2001;12(6):1151-4.
2001: Z Qiu; Dudley K Strickland; Bradley T Hyman; G. William Rebeck
Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro.
Journal of neuropathology and experimental neurology 2001;60(5):430-40.
2001: Hibiki Kawamata; Pamela J McLean; Nutan Sharma; Bradley T Hyman
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.
Journal of neurochemistry 2001;77(3):929-34.
2001: Hyun Soon Cho; Bradley T Hyman; Steven M Greenberg; G. William Rebeck
Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation.
Journal of neuropathology and experimental neurology 2001;60(4):342-9.
2001: G. William Rebeck; Robert D. Moir; Stanley K Mui; Dudley K Strickland; Rudolph E Tanzi; Bradley T Hyman
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.
Brain research. Molecular brain research 2001;87(2):238-45.
2001: Christine Jack; Oksana Berezovska; Michael S Wolfe; Bradley T Hyman
Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Brain research. Molecular brain research 2001;87(2):166-74.
2001: Bradley T Hyman
Molecular and anatomical studies in Alzheimer's disease.
Neurología (Barcelona, Spain) 2001;16(3):100-4.
2001: Yaakov Stern; D Jacobs; J Goldman; E Gomez-Tortosa; Bradley T Hyman; Y Liu; Juan C Troncoso; Karen Marder; Ming-Xin Tang; Jason Brandt; Marilyn S Albert
An investigation of clinical correlates of Lewy bodies in autopsy-proven Alzheimer disease.
Archives of neurology 2001;58(3):460-5.
2001: E Y Kimchi; Stephen T Kajdasz; Brian J Bacskai; Bradley T Hyman
Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy.
Journal of neuropathology and experimental neurology 2001;60(3):274-9.
2001: Richard Christie; M Yamada; Michael A Moskowitz; Bradley T Hyman
Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy.
The American journal of pathology 2001;158(3):1065-71.
2001: Brian J Bacskai; Stephen T Kajdasz; Richard Christie; C Carter; Dora Games; Peter Seubert; Dale Schenk; Bradley T Hyman
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.
Nature medicine 2001;7(3):369-72.
2001: Jang-Ho Cha; L A Farrell; S F Ahmed; A Frey; Karen K. Hsiao Ashe; Anne B Young; John B Penney; Joseph J Locascio; Bradley T Hyman; Michael C Irizarry
Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein.
Neurobiology of disease 2001;8(1):90-102.
2001: Richard Christie; Brian J Bacskai; Warren R Zipfel; R M Williams; Stephen T Kajdasz; Watt W Webb; Bradley T Hyman
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):858-64.
2001: Pamela J McLean; Hibiki Kawamata; Bradley T Hyman
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.
Neuroscience 2001;104(3):901-12.
2001: Lars Bertram; Suzanne Y Guénette; Jennifer Jones; D Keeney; Kristina Mullin; A Crystal; Sanjay Basu; S Yhu; A Deng; G. William Rebeck; Bradley T Hyman; Rodney Go; Melvin G McInnis; Deborah Blacker; Rudolph E Tanzi
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Annals of neurology 2001;49(1):114-6.
2001: Estrella Gómez-Tortosa; Judith L Sanders; Kathy Newell; Bradley T Hyman
Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies.
Acta neuropathologica 2001;101(1):36-42.
2001: Michael C Irizarry; Joseph J Locascio; Bradley T Hyman
beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging.
The American journal of pathology 2001;158(1):173-7.
2000: Suzanne Y Guénette; Lars Bertram; A Crystal; B Bakondi; Bradley T Hyman; G. William Rebeck; Rudolph E Tanzi; Deborah Blacker
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.
Neuroscience letters 2000;296(1):17-20.
2000: J Y Chin; RB Knowles; A Schneider; Gerard Drewes; Eva-Maria Mandelkow; Bradley T Hyman
Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study.
Journal of neuropathology and experimental neurology 2000;59(11):966-71.
2000: Ulrich Finckh; Heinz von der Kammer; J Velden; T Michel; B Andresen; A Deng; J Zhang; Tomas Müller-Thomsen; K Zuchowski; Gunnar Menzer; Ulrike Mann; Andreas Papassotiropoulos; Reinhard Heun; Jan Zurdel; F Holst; Luisa Benussi; Gabriela Stoppe; J Reiss; André R Miserez; Hannes B Staehelin; G. William Rebeck; Bradley T Hyman; Giuliano Binetti; Christoph Hock; John H Growdon; Roger M Nitsch
Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease.
Archives of neurology 2000;57(11):1579-83.
2000: Michael C Irizarry; Bonnie S Cheung; G. William Rebeck; S M Paul; K R Bales; Bradley T Hyman
Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.
Acta neuropathologica 2000;100(5):451-8.
2000: Brian J Bacskai; MengQi Xia; Dudley K Strickland; G. William Rebeck; Bradley T Hyman
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11551-6.
2000: Kohji Matsushita; Y Wu; Jianhua Qiu; L Lang-Lazdunski; Lorenz Hirt; Christian Waeber; Bradley T Hyman; Junying Yuan; Michael A Moskowitz
Fas receptor and neuronal cell death after spinal cord ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6879-87.
2000: MengQi Xia; Brian J Bacskai; R B Knowles; S X Qin; Bradley T Hyman
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease.
Journal of neuroimmunology 2000;108(1-2):227-35.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; W Taylor Kimberly; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: Ruben Vidal; Miguel Calero; Pedro Piccardo; Martin R Farlow; Frederick W Unverzagt; Enrique Méndez; Adolfo Jiménez-Huete; Ronald C Beavis; G Gallo; E Gomez-Tortosa; Jorge Ghiso; Bradley T Hyman; Blas Frangione; Bernardino Ghetti
Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele.
Acta neuropathologica 2000;100(1):1-12.
2000: A Takeuchi; Michael C Irizarry; karen duff; Takaomi C Saido; Karen K. Hsiao Ashe; M Hasegawa; D M A Mann; Bradley T Hyman; Takeshi Iwatsubo
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: Anne M Cataldo; Corrinne M Peterhoff; Juan C Troncoso; T Gomez-Isla; Bradley T Hyman; Ralph A. Nixon
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.
The American journal of pathology 2000;157(1):277-86.
2000: David M Holtzman; Anne M Fagan; B Mackey; T Tenkova; L Sartorius; Steven M Paul; K Bales; Karen K. Hsiao Ashe; Michael C Irizarry; Bradley T Hyman
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.
Annals of neurology 2000;47(6):739-47.
2000: Sergey V Buldyrev; Luis Cruz; T Gomez-Isla; E Gomez-Tortosa; Shlomo Havlin; R Le; H Eugene Stanley; Brigita Urbanc; Bradley T Hyman
Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5039-43.
2000: Bradley T Hyman; Dudley K Strickland; G. William Rebeck
Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease.
Archives of neurology 2000;57(5):646-50.
2000: Estrella Gómez-Tortosa; Kathy Newell; Michael C Irizarry; Judith L Sanders; Bradley T Hyman
alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining.
Acta neuropathologica 2000;99(4):352-7.
2000: Ronald J Killiany; T Gomez-Isla; M Moss; R Kikinis; T Sandor; Ferenc A Jolesz; Rudolph E Tanzi; K Jones; Bradley T Hyman; Marilyn S Albert
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.
Annals of neurology 2000;47(4):430-9.
2000: Pamela J McLean; Hibiki Kawamata; S Ribich; Bradley T Hyman
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.
The Journal of biological chemistry 2000;275(12):8812-6.
2000: Paula G Ulery; J Beers; Irina Mikhailenko; Rudolph E Tanzi; G. William Rebeck; Bradley T Hyman; Dudley K Strickland
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
The Journal of biological chemistry 2000;275(10):7410-5.
2000: Estrella Gómez-Tortosa; Michael C Irizarry; T Gómez-Isla; Bradley T Hyman
Clinical and neuropathological correlates of dementia with Lewy bodies.
Annals of the New York Academy of Sciences 2000;920():9-15.
2000: Oksana Berezovska; Christine Jack; Pamela J McLean; Jon C Aster; C Hicks; Weiming Xia; Michael S Wolfe; G Weinmaster; Dennis J Selkoe; Bradley T Hyman
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: Michael C Irizarry; G. William Rebeck; B Cheung; K Bales; S M Paul; D Holzman; Bradley T Hyman
Modulation of A beta deposition in APP transgenic mice by an apolipoprotein E null background.
Annals of the New York Academy of Sciences 2000;920():171-8.
2000: Pamela J McLean; S Ribich; Bradley T Hyman
Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations.
Journal of neural transmission. Supplementum 2000;(58):53-63.
1999: T Gómez-Isla; Whitfield B Growdon; MJ McNamara; Kathy Newell; Estrella Gómez-Tortosa; E Tessa Hedley-Whyte; Bradley T Hyman
Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies.
Neurology 1999;53(9):2003-9.
1999: KL Newell; P Boyer; E Gomez-Tortosa; Wendy Hobbs; E Tessa Hedley-Whyte; Jean-Paul Vonsattel; Bradley T Hyman
Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury.
Journal of neuropathology and experimental neurology 1999;58(12):1263-8.
1999: KL Newell; Bradley T Hyman; John H Growdon; E Tessa Hedley-Whyte
Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease.
Journal of neuropathology and experimental neurology 1999;58(11):1147-55.
1999: Estrella Gómez-Tortosa; Kathy Newell; Michael C Irizarry; Marilyn S Albert; John H Growdon; Bradley T Hyman
Clinical and quantitative pathologic correlates of dementia with Lewy bodies.
Neurology 1999;53(6):1284-91.
1999: RB Knowles; J Chin; C T Ruff; Bradley T Hyman
Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: implications for MAP kinase activation in Alzheimer disease.
Journal of neuropathology and experimental neurology 1999;58(10):1090-8.
1999: Irina Mikhailenko; W Considine; Kelley M Argraves; Dmitri Loukinov; Bradley T Hyman; Dudley K Strickland
Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms.
Journal of cell science 1999;112 ( Pt 19)():3269-81.
1999: Z Qiu; Dudley K Strickland; Bradley T Hyman; G. William Rebeck
Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.
Journal of neurochemistry 1999;73(4):1393-8.
1999: G. William Rebeck; Bonnie S Cheung; Whitfield B Growdon; Amy Deng; P Akuthota; Joseph J Locascio; Steven M Greenberg; Bradley T Hyman
Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease.
Neuroscience letters 1999;272(3):155-8.
1999: Whitfield B Growdon; Bonnie S Cheung; Bradley T Hyman; G. William Rebeck
Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease.
Neuroscience letters 1999;272(2):83-6.
1999: T Gómez-Isla; Whitfield B Growdon; MJ McNamara; David Nochlin; Thomas D Bird; JC Arango; Francisco Lopera; Kenneth S Kosik; P L Lantos; Nigel J Cairns; Bradley T Hyman
The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors.
Brain : a journal of neurology 1999;122 ( Pt 9)():1709-19.
1999: Brigita Urbanc; Luis Cruz; Sergey V Buldyrev; Shlomo Havlin; Bradley T Hyman; H Eugene Stanley
Dynamic feedback in an aggregation-disaggregation model.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics 1999;60(2 Pt B):2120-6.
1999: Oksana Berezovska; M Frosch; Pamela J McLean; R Knowles; Edward H Koo; David E Kang; Jie Shen; F M Lu; Samuel E Lux; Susumu Tonegawa; Bradley T Hyman
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
Brain research. Molecular brain research 1999;69(2):273-80.
1999: RB Knowles; Claire Wyart; Sergey V Buldyrev; Luis Cruz; Brigita Urbanc; Michael Hasselmo; H Eugene Stanley; Bradley T Hyman
Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5274-9.
1999: AE Clatworthy; Walter Stockinger; R H Christie; Wolfgang J Schneider; Johannes Nimpf; Bradley T Hyman; G. William Rebeck
Expression and alternate splicing of apolipoprotein E receptor 2 in brain.
Neuroscience 1999;90(3):903-11.
1999: Paul F Chapman; G L White; Matt W Jones; D Cooper-Blacketer; VJ Marshall; Michael C Irizarry; Linda Younkin; Mark A Good; T V Bliss; Bradley T Hyman; Steven G Younkin; KK Hsiao
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.
Nature neuroscience 1999;2(3):271-6.
1999: Brigita Urbanc; Luis Cruz; Sergey V Buldyrev; Shlomo Havlin; Michael C Irizarry; H Eugene Stanley; Bradley T Hyman
Dynamics of plaque formation in Alzheimer's disease.
Biophysical journal 1999;76(3):1330-4.
1999: MengQi Xia; Bradley T Hyman
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease.
Journal of neurovirology 1999;5(1):32-41.
1999: A Liao; T Gómez-Isla; AE Clatworthy; Bradley T Hyman
Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.
Brain research 1999;816(2):295-8.
1999: Oksana Berezovska; Pamela J McLean; R Knowles; M Frosh; F M Lu; Samuel E Lux; Bradley T Hyman
Notch1 inhibits neurite outgrowth in postmitotic primary neurons.
Neuroscience 1999;93(2):433-9.
1999: Michael C Irizarry; S Nassir Ghaemi; E R Lee-Cherry; Teresa Gomez-Isla; Giuliano Binetti; Bradley T Hyman; John H Growdon
Risperidone treatment of behavioral disturbances in outpatients with dementia.
The Journal of neuropsychiatry and clinical neurosciences 1999;11(3):336-42.
1998: RB Knowles; Teresa Gomez-Isla; Bradley T Hyman
Abeta associated neuropil changes: correlation with neuronal loss and dementia.
Journal of neuropathology and experimental neurology 1998;57(12):1122-30.
1998: A Liao; Roger M Nitsch; Steven M Greenberg; Ulrich Finckh; Deborah Blacker; Marilyn S Albert; G. William Rebeck; Teresa Gomez-Isla; AE Clatworthy; Giuliano Binetti; Christoph Hock; T Mueller-Thomsen; Ulrike Mann; K Zuchowski; U Beisiegel; Hannes B Staehelin; John H Growdon; Rudolph E Tanzi; Bradley T Hyman
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Human molecular genetics 1998;7(12):1953-6.
1998: Estrella Gómez-Tortosa; A O Ingraham; Michael C Irizarry; Bradley T Hyman
Dementia with Lewy bodies.
Journal of the American Geriatrics Society 1998;46(11):1449-58.
1998: Liling Yang; Russell T Matthews; J B Schulz; T Klockgether; A W Liao; J C Martinou; John B Penney; Bradley T Hyman; M Flint Beal
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8145-52.
1998: Bradley T Hyman
New neuropathological criteria for Alzheimer disease.
Archives of neurology 1998;55(9):1174-6.
1998: MJ McNamara; C T Ruff; Wilma Wasco; Rudolph E Tanzi; Gopal Thinakaran; Bradley T Hyman
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
Brain research 1998;804(1):45-51.
1998: Oksana Berezovska; MengQi Xia; Bradley T Hyman
Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease.
Journal of neuropathology and experimental neurology 1998;57(8):738-45.
1998: Deborah Blacker; Marsha A. Wilcox; Nan M Laird; L Rodes; S M Horvath; Rodney C P Go; Rodney T Perry; Bracie Watson; Susan S Bassett; Melvin G McInnis; Marilyn S Albert; Bradley T Hyman; Rudolph E Tanzi
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
Nature genetics 1998;19(4):357-60.
1998: K J Page; RD Hollister; Bradley T Hyman
Dissociation of apolipoprotein and apolipoprotein receptor response to lesion in the rat brain: an in situ hybridization study.
Neuroscience 1998;85(4):1161-71.
1998: M J McNamara; Teresa Gomez-Isla; Bradley T Hyman
Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease.
Archives of neurology 1998;55(7):1001-4.
1998: MengQi Xia; S X Qin; L J Wu; C R Mackay; Bradley T Hyman
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains.
The American journal of pathology 1998;153(1):31-7.
1998: MengQi Xia; Oksana Berezovska; TW Kim; W M Xia; A Liao; Rudolph E Tanzi; Dennis J Selkoe; Bradley T Hyman
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Journal of the neurological sciences 1998;158(1):15-23.
1998: Alan Peters; J H Morrison; Douglas Rosene; Bradley T Hyman
Feature article: are neurons lost from the primate cerebral cortex during normal aging?
Cerebral cortex (New York, N.Y. : 1991) 1998;8(4):295-300.
1998: E Hollenbach; S Ackermann; Bradley T Hyman; G. William Rebeck
Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.
Neurology 1998;50(6):1905-7.
1998: Bradley T Hyman
Neuronal loss in Alzheimer's disease.
Aging (Milan, Italy) 1998;10(2):156.
1998: N C Alonzo; Bradley T Hyman; G. William Rebeck; Steven M Greenberg
Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels.
Journal of neuropathology and experimental neurology 1998;57(4):353-9.
1998: Michael C Irizarry; Whitfield B Growdon; Teresa Gomez-Isla; Kathy Newell; Julia M George; David F Clayton; Bradley T Hyman
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.
Journal of neuropathology and experimental neurology 1998;57(4):334-7.
1998: Bradley T Hyman; Teresa Gomez-Isla; Michael C Irizarry
Stereology: a practical primer for neuropathology.
Journal of neuropathology and experimental neurology 1998;57(4):305-10.
1998: Steven M Greenberg; Jean-Paul Vonsattel; Alan Z Segal; RI Chiu; AE Clatworthy; A Liao; Bradley T Hyman; G. William Rebeck
Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy.
Neurology 1998;50(4):961-5.
1998: Anuja Ghorpade; MengQi Xia; Bradley T Hyman; Yuri Persidsky; Adeline Nukuna; P Bock; MH Che; Jenae Limoges; Howard E Gendelman; C R Mackay
Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia.
Journal of virology 1998;72(4):3351-61.
1998: M Silver; Kathy Newell; Bradley T Hyman; John H Growdon; E Tessa Hedley-Whyte; Thomas T Perls
Unraveling the mystery of cognitive changes in old age: correlation of neuropsychological evaluation with neuropathological findings in the extreme old.
International psychogeriatrics / IPA 1998;10(1):25-41.
1998: Bradley T Hyman
Biomarkers in Alzheimer's disease.
Neurobiology of aging 1998;19(2):159-60.
1998: Matthias Endres; Shobu Namura; M Shimizu-Sasamata; Christian Waeber; L Zhang; T Gómez-Isla; Bradley T Hyman; Michael A Moskowitz
Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(3):238-47.
1998: Richard Mayeux; Ann M Saunders; S Shea; Suzanne S Mirra; Denis A Evans; Allen D Roses; Bradley T Hyman; Barbara J Crain; Ming-Xin Tang; C H Phelps
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.
The New England journal of medicine 1998;338(8):506-11.
1998: G. William Rebeck; N C Alonzo; Oksana Berezovska; S D Harr; R B Knowles; John H Growdon; Bradley T Hyman; Armando J Mendez
Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes.
Experimental neurology 1998;149(1):175-82.
1998: Sally A Frautschy; Fusheng Yang; M Irrizarry; Bradley T Hyman; Takaomi C Saido; Karen K. Hsiao Ashe; Gregory M. Cole
Microglial response to amyloid plaques in APPsw transgenic mice.
The American journal of pathology 1998;152(1):307-17.
1997: Luigi Ferrucci; J M Guralnik; Marco Pahor; T Harris; Maria Chiara Corti; Bradley T Hyman; R B Wallace; Richard J Havlik
Apolipoprotein E epsilon 2 allele and risk of stroke in the older population.
Stroke; a journal of cerebral circulation 1997;28(12):2410-6.
1997: Lindsay A Farrer; L Adrienne Cupples; Jonathan L Haines; Bradley T Hyman; Walter A Kukull; Richard Mayeux; Richard H Myers; Margaret Pericak-Vance; N Risch; C.M. Duijn
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
JAMA : the journal of the American Medical Association 1997;278(16):1349-56.
1997: AE Clatworthy; Teresa Gomez-Isla; G. William Rebeck; R B Wallace; Bradley T Hyman
Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.
Archives of neurology 1997;54(10):1289-92.
1997: Bradley T Hyman; John Q Trojanowski
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.
Journal of neuropathology and experimental neurology 1997;56(10):1095-7.
1997: Michael C Irizarry; F Soriano; M McNamara; K J Page; Dale Schenk; Dora Games; Bradley T Hyman
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):7053-9.
1997: Cenk Ayata; G Ayata; H Hara; Russell T Matthews; M Flint Beal; Robert J Ferrante; Matthias Endres; A Kim; Richard Christie; Christian Waeber; Paul L Huang; Bradley T Hyman; Michael A Moskowitz
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6908-17.
1997: Christian K Vorwerk; Bradley T Hyman; Joan W Miller; Deeba Husain; D Zurakowski; P L Huang; M C Fishman; Evan B Dreyer
The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity.
Investigative ophthalmology & visual science 1997;38(10):2038-44.
1997: Michael C Irizarry; M McNamara; K Fedorchak; Karen K. Hsiao Ashe; Bradley T Hyman
APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.
Journal of neuropathology and experimental neurology 1997;56(9):965-73.
1997: RD Hollister; K J Page; Bradley T Hyman
Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions.
Neuroscience 1997;79(4):1111-9.
1997: Luis Cruz; Brigita Urbanc; Sergey V Buldyrev; R Christie; T Gómez-Isla; Shlomo Havlin; MJ McNamara; H Eugene Stanley; Bradley T Hyman
Aggregation and disaggregation of senile plaques in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7612-6.
1997: Bradley T Hyman
The neuropathological diagnosis of Alzheimer's disease: clinical-pathological studies.
Neurobiology of aging 1997;18(4 Suppl):S27-32.
1997: Bradley T Hyman; T Gomez-Isla
The natural history of Alzheimer neurofibrillary tangles and amyloid deposits.
Neurobiology of aging 1997;18(4):386-7; discussion 389-92.
1997: T Gómez-Isla; Wilma Wasco; W P Pettingell; S Gurubhagavatula; S D Schmidt; P D Jondro; MJ McNamara; L A Rodes; T DiBlasi; Whitfield B Growdon; Peter Seubert; Dale Schenk; John H Growdon; Bradley T Hyman; Rudolph E Tanzi
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.
Annals of neurology 1997;41(6):809-13.
1997: Steven M Greenberg; Bradley T Hyman
Cerebral amyloid angiopathy and apolipoprotein E: bad news for the good allele?
Annals of neurology 1997;41(6):701-2.
1997: Suzanne Corkin; David G Amaral; R G González; Keith A Johnson; Bradley T Hyman
H. M.'s medial temporal lobe lesion: findings from magnetic resonance imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(10):3964-79.
1997: MengQi Xia; S Qin; M McNamara; C Mackay; Bradley T Hyman
Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.
The American journal of pathology 1997;150(4):1267-74.
1997: J Fallon; Russell T Matthews; Bradley T Hyman; M Flint Beal
MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.
Experimental neurology 1997;144(1):193-8.
1997: RD Hollister; M Xia; M J McNamara; Bradley T Hyman
Neuronal expression of class II major histocompatibility complex (HLA-DR) in 2 cases of Pick disease.
Archives of neurology 1997;54(3):243-8.
1997: Jaime García-Añoveros; Bruce H Derfler; J Neville-Golden; Bradley T Hyman; David P Corey
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1459-64.
1997: Russell T Matthews; M Flint Beal; J Fallon; K Fedorchak; P L Huang; M C Fishman; Bradley T Hyman
MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice.
Neurobiology of disease 1997;4(2):114-21.
1997: T Gómez-Isla; RD Hollister; H West; S Mui; John H Growdon; Ronald C. Petersen; Joseph E Parisi; Bradley T Hyman
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.
Annals of neurology 1997;41(1):17-24.
1997: Oksana Berezovska; MengQi Xia; K Page; Wilma Wasco; Rudolph E Tanzi; Bradley T Hyman
Developmental regulation of presenilin mRNA expression parallels notch expression.
Journal of neuropathology and experimental neurology 1997;56(1):40-4.
1996: A L Biere; Beth L Ostaszewski; Evelyn R Stimson; Bradley T Hyman; John E Maggio; Dennis J Selkoe
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma.
The Journal of biological chemistry 1996;271(51):32916-22.
1996: Bradley T Hyman; Teresa Gomez-Isla; G. William Rebeck; M Briggs; H Chung; H L West; Steven A Greenberg; S Mui; S Nichols; R Wallace; John H Growdon
Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;802():1-5.
1996: Bradley T Hyman
Apolipoprotein E genotype: utility in clinical practice in Alzheimer's disease.
Journal of the American Geriatrics Society 1996;44(12):1469-71.
1996: K Page; RD Hollister; Rudolph E Tanzi; Bradley T Hyman
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14020-4.
1996: Bradley T Hyman; Teresa Gomez-Isla
Neuropathological markers of impaired cognition in the entorhinal cortex.
Neurobiology of aging 1996;17(6):940-1; discussion 945-7.
1996: Bradley T Hyman
Alzheimer's disease or Alzheimer's diseases? Clues from molecular epidemiology.
Annals of neurology 1996;40(2):135-6.
1996: Michael C Irizarry; T W Kim; M McNamara; Rudolph E Tanzi; Julia M George; David F Clayton; Bradley T Hyman
Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.
Journal of neuropathology and experimental neurology 1996;55(8):889-95.
1996: John H Growdon; J J Locascio; Suzanne Corkin; Teresa Gomez-Isla; Bradley T Hyman
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease.
Neurology 1996;47(2):444-8.
1996: Steven M Greenberg; M E Briggs; Bradley T Hyman; G J Kokoris; C Takis; D S Kanter; C S Kase; Michael S Pessin
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy.
Stroke; a journal of cerebral circulation 1996;27(8):1333-7.
1996: RD Hollister; W Kisiel; Bradley T Hyman
Immunohistochemical localization of tissue factor pathway inhibitor-1 (TFPI-1), a Kunitz proteinase inhibitor, in Alzheimer's disease.
Brain research 1996;728(1):13-9.
1996: T Gómez-Isla; J L Price; D W McKeel; John C Morris; John H Growdon; Bradley T Hyman
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(14):4491-500.
1996: S Mui; M Briggs; H Chung; R B Wallace; Teresa Gomez-Isla; G. William Rebeck; Bradley T Hyman
A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele.
Neurology 1996;47(1):196-201.
1996: Bradley T Hyman; Teresa Gomez-Isla; M Briggs; H Chung; S Nichols; F Kohout; R Wallace
Apolipoprotein E and cognitive change in an elderly population.
Annals of neurology 1996;40(1):55-66.
1996: Christian K Vorwerk; S A Lipton; David Zurakowski; Bradley T Hyman; Bernhard A Sabel; Evan B Dreyer
Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine.
Investigative ophthalmology & visual science 1996;37(8):1618-24.
1996: H Chung; C T Roberts; Steven A Greenberg; G. William Rebeck; R Christie; R Wallace; H J Jacob; Bradley T Hyman
Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease.
Annals of neurology 1996;39(6):800-3.
1996: S D Harr; L Uint; RD Hollister; Bradley T Hyman; Armando J Mendez
Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease.
Journal of neurochemistry 1996;66(6):2429-35.
1996: S D Harr; RD Hollister; Bradley T Hyman
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.
Neurobiology of aging 1996;17(3):343-8.
1996: R H Christie; H Chung; G. William Rebeck; Dudley K Strickland; Bradley T Hyman
Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1996;55(4):491-8.
1996: Bradley T Hyman; E T Hedley-Whyte; G. William Rebeck; J P Vonsattel; H L West; John H Growdon
Apolipoprotein E epsilon4/4 in a neuropathologically normal very elderly individual.
Archives of neurology 1996;53(3):215.
1996: Carol F Lippa; Ann M Saunders; T W Smith; Joan M Swearer; David Drachman; Bernardino Ghetti; Linda E Nee; D Pulaski-Salo; dennis dickson; Y Robitaille; C Bergeron; Barbara J Crain; M D Benson; Martin R Farlow; Bradley T Hyman; S P George-Hyslop; Allen D Roses; Daniel A Pollen
Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.
Neurology 1996;46(2):406-12.
1996: R H Christie; M Freeman; Bradley T Hyman
Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.
The American journal of pathology 1996;148(2):399-403.
1996: Dora M. Kovacs; H J Fausett; K J Page; TW Kim; Robert D. Moir; D E Merriam; RD Hollister; O G Hallmark; R Mancini; K M Felsenstein; Bradley T Hyman; Rudolph E Tanzi; Wilma Wasco
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.
Nature medicine 1996;2(2):224-9.
1996: Bradley T Hyman; Teresa Gomez-Isla; H West; M Briggs; H Chung; John H Growdon; G. William Rebeck
Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology.
Annals of the New York Academy of Sciences 1996;777():158-65.
1996: Teresa Gomez-Isla; H L West; G. William Rebeck; S D Harr; John H Growdon; J J Locascio; T T Perls; L A Lipsitz; Bradley T Hyman
Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease.
Annals of neurology 1996;39(1):62-70.
1995: Bradley T Hyman; Rudolph E Tanzi
Molecular epidemiology of Alzheimer's disease.
The New England journal of medicine 1995;333(19):1283-4.
1995: Marla Gearing; Julie A Schneider; R S Robbins; R D Hollister; Hiroshi Mori; D Games; Bradley T Hyman; Suzanne S Mirra
Regional variation in the distribution of apolipoprotein E and A beta in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1995;54(6):833-41.
1995: Marla Gearing; Julie A Schneider; G. William Rebeck; Bradley T Hyman; Suzanne S Mirra
Alzheimer's disease with and without coexisting Parkinson's disease changes: apolipoprotein E genotype and neuropathologic correlates.
Neurology 1995;45(11):1985-90.
1995: A Poduri; Lori L Beason-Held; Mark B Moss; Douglas Rosene; Bradley T Hyman
CA3 neuronal degeneration follows chronic entorhinal cortex lesions.
Neuroscience letters 1995;197(1):1-4.
1995: S Mui; G. William Rebeck; D McKenna-Yasek; Bradley T Hyman; R H Brown
Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis.
Annals of neurology 1995;38(3):460-3.
1995: Steven M Greenberg; G. William Rebeck; Jean-Paul Vonsattel; Teresa Gomez-Isla; Bradley T Hyman
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy.
Annals of neurology 1995;38(2):254-9.
1995: M Z Kounnas; Robert D. Moir; G. William Rebeck; Ashley I Bush; Scott Argraves; Rudolph E Tanzi; Bradley T Hyman; Dudley K Strickland
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Cell 1995;82(2):331-40.
1995: N A Simonian; Bradley T Hyman
Functional alterations in neural circuits in Alzheimer's disease.
Neurobiology of aging 1995;16(3):305-9.
1995: Bradley T Hyman; H L West; G. William Rebeck; Sergey V Buldyrev; R N Mantegna; M Ukleja; Shlomo Havlin; H Eugene Stanley
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3586-90.
1995: Roger M Nitsch; G. William Rebeck; M Deng; U I Richardson; M Tennis; Dale Schenk; C Vigo-Pelfrey; I Lieberburg; Richard Jay Wurtman; Bradley T Hyman
Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype.
Annals of neurology 1995;37(4):512-8.
1995: Bradley T Hyman; H L West; G. William Rebeck; F Lai; D M A Mann
Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.
Archives of neurology 1995;52(4):373-8.
1995: G. William Rebeck; Bradley T Hyman
Apolipoprotein E--correction.
Neurology 1995;45(3 Pt 1):598.
1995: J A Golden; G P Nielsen; B R Pober; Bradley T Hyman
The neuropathology of Williams syndrome. Report of a 35-year-old man with presenile beta/A4 amyloid plaques and neurofibrillary tangles.
Archives of neurology 1995;52(2):209-12.
1995: G. William Rebeck; S D Harr; Dudley K Strickland; Bradley T Hyman
Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.
Annals of neurology 1995;37(2):211-7.
1995: Allen D Roses; Ann M Saunders; Warren J Strittmatter; Donald E Schmechel; Margaret Pericak-Vance; Bradley T Hyman
Apolipoprotein E in Creutzfeldt-Jacob disease.
Lancet 1995;345(8941):69.
1995: S D Harr; N A Simonian; Bradley T Hyman
Functional alterations in Alzheimer's disease: decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone.
Journal of neuropathology and experimental neurology 1995;54(1):38-41.
1994: Emmanuel Brouillet; Bradley T Hyman; Bruce G Jenkins; D R Henshaw; Jörg B Schulz; P Sodhi; Bruce R Rosen; M Flint Beal
Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism.
Experimental neurology 1994;129(2):175-82.
1994: Marla Gearing; G. William Rebeck; Bradley T Hyman; Johannes Tigges; Suzanne S Mirra
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9382-6.
1994: N A Simonian; T Elvhage; A J Czernik; Paul Greengard; Bradley T Hyman
Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons.
Brain research 1994;657(1-2):294-9.
1994: Bradley T Hyman; Dudley K Strickland; G. William Rebeck
Alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Relationship to apolipoprotein E and role in Alzheimer disease senile plaques.
Annals of the New York Academy of Sciences 1994;737():88-95.
1994: J A Golden; Bradley T Hyman
Development of the superior temporal neocortex is anomalous in trisomy 21.
Journal of neuropathology and experimental neurology 1994;53(5):513-20.
1994: N A Simonian; Bradley T Hyman
Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation.
Journal of neuropathology and experimental neurology 1994;53(5):508-12.
1994: Bradley T Hyman; R D Terry
Apolipoprotein E, A beta, and Alzheimer disease.
Journal of neuropathology and experimental neurology 1994;53(5):427-8.
1994: G. William Rebeck; T T Perls; H L West; P Sodhi; Lewis A Lipsitz; Bradley T Hyman
Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals.
Neurology 1994;44(8):1513-6.
1994: H L West; G. William Rebeck; Bradley T Hyman
Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease.
Neuroscience letters 1994;175(1-2):46-8.
1994: A Poduri; Marla Gearing; G. William Rebeck; Suzanne S Mirra; Johannes Tigges; Bradley T Hyman
Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.
The American journal of pathology 1994;144(6):1183-7.
1994: Bradley T Hyman; Teresa Gomez-Isla
Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.
Neurobiology of aging 1994;15(3):353-4; discussion 379-80.
1994: G. William Rebeck; Kenneth I Maynard; Bradley T Hyman; Michael A Moskowitz
Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3666-9.
1994: Bradley T Hyman; T E Elvhage; J Reiter
Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.
The American journal of pathology 1994;144(3):565-72.
1994: Steven E Arnold; Bradley T Hyman; G W Van Hoesen
Neuropathologic changes of the temporal pole in Alzheimer's disease and Pick's disease.
Archives of neurology 1994;51(2):145-50.
1994: Bradley T Hyman; J Reiter; M Moss; Douglas Rosene; D Pandya
Extracellular signal-regulated kinase (MAP kinase) immunoreactivity in the rhesus monkey brain.
Neuroscience letters 1994;166(1):113-6.
1994: Bradley T Hyman; John B Penney; C D Blackstone; Anne B Young
Localization of non-N-methyl-D-aspartate glutamate receptors in normal and Alzheimer hippocampal formation.
Annals of neurology 1994;35(1):31-7.
1994: N A Simonian; G. William Rebeck; Bradley T Hyman
Functional integrity of neural systems related to memory in Alzheimer's disease.
Progress in brain research 1994;100():245-54.
1994: Bradley T Hyman
Studying the Alzheimer's disease brain: insights, puzzles, and opportunities.
Neurobiology of aging 1994;15 Suppl 2():S79-83.
1993: Bradley T Hyman; K Marzloff; P V Arriagada
The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution.
Journal of neuropathology and experimental neurology 1993;52(6):594-600.
1993: N A Simonian; Bradley T Hyman
Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation.
Journal of neuropathology and experimental neurology 1993;52(6):580-5.
1993: G. William Rebeck; J S Reiter; Dudley K Strickland; Bradley T Hyman
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions.
Neuron 1993;11(4):575-80.
1993: M Flint Beal; Emmanuel Brouillet; Bruce G Jenkins; Robert J Ferrante; Neil W Kowall; J M Miller; E Storey; R Srivastava; Bruce R Rosen; Bradley T Hyman
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4181-92.
1993: Wilma Wasco; S Gurubhagavatula; M D Paradis; Donna M Romano; Sangram S Sisodia; Bradley T Hyman; R L Neve; Rudolph E Tanzi
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
Nature genetics 1993;5(1):95-100.
1993: M Flint Beal; Emmanuel Brouillet; B Jenkins; R Henshaw; B Rosen; Bradley T Hyman
Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate.
Journal of neurochemistry 1993;61(3):1147-50.
1993: R Srivastava; Emmanuel Brouillet; M Flint Beal; E Storey; Bradley T Hyman
Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss.
Neurobiology of aging 1993;14(4):295-301.
1993: Rudolph E Tanzi; J J Wenniger; Bradley T Hyman
Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation.
Brain research. Molecular brain research 1993;18(3):246-52.
1993: Bradley T Hyman; J J Wenniger; Rudolph E Tanzi
Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques.
Brain research. Molecular brain research 1993;18(3):253-8.
1993: G. William Rebeck; K Marzloff; Bradley T Hyman
The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease.
Neuroscience letters 1993;152(1-2):165-8.
1993: M Flint Beal; Bradley T Hyman; Walter J Koroshetz
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
Trends in neurosciences 1993;16(4):125-31.
1993: G. William Rebeck; Bradley T Hyman
Neuroanatomical connections and specific regional vulnerability in Alzheimer's disease.
Neurobiology of aging 1993;14(1):45-7; discussion 55-6.
1993: Emmanuel Brouillet; Bruce G Jenkins; Bradley T Hyman; Robert J Ferrante; Neil W Kowall; R Srivastava; D S Roy; B R Rosen; M Flint Beal
Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.
Journal of neurochemistry 1993;60(1):356-9.
1992: Bradley T Hyman; K Marzloff; J J Wenniger; Ted M Dawson; D S Bredt; Solomon H Snyder
Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease.
Annals of neurology 1992;32(6):818-20.
1992: P V Arriagada; K Marzloff; Bradley T Hyman
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease.
Neurology 1992;42(9):1681-8.
1992: Rudolph E Tanzi; Giovanna Vaula; Donna M Romano; M Mortilla; T L Huang; R G Tupler; Wilma Wasco; Bradley T Hyman; Jonathan L Haines; B J Jenkins
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
American journal of human genetics 1992;51(2):273-82.
1992: E Storey; Bradley T Hyman; B Jenkins; Emmanuel Brouillet; J M Miller; Bruce R Rosen; M Flint Beal
1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.
Journal of neurochemistry 1992;58(5):1975-8.
1992: P V Arriagada; John H Growdon; E Tessa Hedley-Whyte; Bradley T Hyman
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease.
Neurology 1992;42(3 Pt 1):631-9.
1992: L M Cabalka; Bradley T Hyman; C R Goodlett; T C Ritchie; Gary W Van Hoesen
Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions.
Neurobiology of aging 1992;13(2):283-91.
1992: Bradley T Hyman; Rudolph E Tanzi
Amyloid, dementia and Alzheimer's disease.
Current opinion in neurology and neurosurgery 1992;5(1):88-93.
1992: Bradley T Hyman; Rudolph E Tanzi; K Marzloff; R Barbour; Dale Schenk
Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1992;51(1):76-83.
1992: D N Louis; P V Arriagada; Bradley T Hyman; E Tessa Hedley-Whyte
Olfactory dysgenesis or hypoplasia: a variant in the arhinencephaly spectrum?
Neurology 1992;42(1):179-82.
1992: Bradley T Hyman
Down syndrome and Alzheimer disease.
Progress in clinical and biological research 1992;379():123-42.
1991: S F Finn; Bradley T Hyman; E Storey; J M Miller; M Flint Beal
Effects of aging on quinolinic acid lesions in rat striatum.
Brain research 1991;562(2):276-80.
1991: Bradley T Hyman; J E Flory; Steven E Arnold; G W Van Hoesen; R L Schelper; H Ghanbari; H Haigler
Quantitative assessment of ALZ-50 immunoreactivity in Alzheimer's disease.
Journal of geriatric psychiatry and neurology 1991;4(4):231-5.
1991: M Flint Beal; K J Swartz; Bradley T Hyman; E Storey; S F Finn; Walter J Koroshetz
Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism.
Journal of neurochemistry 1991;57(3):1068-73.
1991: Steven E Arnold; Bradley T Hyman; Gary W Van Hoesen; Antonio R Damasio
Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia.
Archives of general psychiatry 1991;48(7):625-32.
1991: Rudolph E Tanzi; Bradley T Hyman
Alzheimer's mutation.
Nature 1991;350(6319):564.
1991: P V Arriagada; D N Louis; E Tessa Hedley-Whyte; Bradley T Hyman
Neurofibrillary tangles and olfactory dysgenesis.
Lancet 1991;337(8740):559.
1991: J M Schumacher; M P Short; Bradley T Hyman; X O Breakefield; Ole Isacson
Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids.
Neuroscience 1991;45(3):561-70.
1991: Steven E Arnold; Bradley T Hyman; J Flory; Antonio R Damasio; Gary W Van Hoesen
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease.
Cerebral cortex (New York, N.Y. : 1991) 1991;1(1):103-16.
1991: Rudolph E Tanzi; Bradley T Hyman
Studies of amyloid beta-protein precursor expression in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():149-54.
1991: Bradley T Hyman; P V Arriagada; G W Van Hoesen
Pathologic changes in the olfactory system in aging and Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():14-9.
1991: G W Van Hoesen; Bradley T Hyman; A R Damasio
Entorhinal cortex pathology in Alzheimer's disease.
Hippocampus 1991;1(1):1-8.
1990: Bradley T Hyman; G W Van Hoesen; A R Damasio
Memory-related neural systems in Alzheimer's disease: an anatomic study.
Neurology 1990;40(11):1721-30.
1990: W G Tourtellotte; Gary W Van Hoesen; Bradley T Hyman; R K Tikoo; A R Damasio
Alz-50 immunoreactivity in the thalamic reticular nucleus in Alzheimer's disease.
Brain research 1990;515(1-2):227-34.
1990: Neill R Graff-Radford; Antonio R Damasio; Bradley T Hyman; M N Hart; Daniel Tranel; Hanna Damasio; Gary W Van Hoesen; K Rezai
Progressive aphasia in a patient with Pick's disease: a neuropsychological, radiologic, and anatomic study.
Neurology 1990;40(4):620-6.
1990: Daniel Tranel; Bradley T Hyman
Neuropsychological correlates of bilateral amygdala damage.
Archives of neurology 1990;47(3):349-55.
1990: Gary W Van Hoesen; Bradley T Hyman
Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease.
Progress in brain research 1990;83():445-57.
1990: L J Kromer Vogt; Bradley T Hyman; G W Van Hoesen; A R Damasio
Pathological alterations in the amygdala in Alzheimer's disease.
Neuroscience 1990;37(2):377-85.
1989: Bradley T Hyman; Gary W Van Hoesen; Konrad Beyreuther; Colin L Masters
A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
Neuroscience letters 1989;101(3):352-5.
1989: Bradley T Hyman; Daniel Tranel
Hemianesthesia and aphasia. An anatomical and behavioral study.
Archives of neurology 1989;46(7):816-9.
1989: K M Hamre; Bradley T Hyman; C R Goodlett; JR West; Gary W Van Hoesen
Alz-50 immunoreactivity in the neonatal rat: changes in development and co-distribution with MAP-2 immunoreactivity.
Neuroscience letters 1989;98(3):264-71.
1989: Bradley T Hyman; H Damasio; A R Damasio; G W Van Hoesen
Alzheimer's disease.
Annual review of public health 1989;10():115-40.
1988: Bradley T Hyman; L J Kromer; Gary W Van Hoesen
A direct demonstration of the perforant pathway terminal zone in Alzheimer's disease using the monoclonal antibody Alz-50.
Brain research 1988;450(1-2):392-7.
1988: Richard M Niles; K. Chul Kim; Bradley T Hyman; T Christensen; K Wasano; J Brody
Characterization of extended primary and secondary cultures of hamster tracheal epithelial cells.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(5):457-63.
1988: Bradley T Hyman; Gary W Van Hoesen; Benjamin Wolozin; Peter Davies; L J Kromer; Antonio R Damasio
Alz-50 antibody recognizes Alzheimer-related neuronal changes.
Annals of neurology 1988;23(4):371-9.
1987: Bradley T Hyman; Gary W Van Hoesen
Neuron numbers in Alzheimer's disease: cell-specific pathology.
Neurobiology of aging 1987;8(6):555-6.
1987: Bradley T Hyman; G W Van Hoesen; A R Damasio
Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone.
Annals of neurology 1987;22(1):37-40.
1987: Bradley T Hyman; S K Landas; R F Ashman; RL Schelper; R A Robinson
Warfarin-related purple toes syndrome and cholesterol microembolization.
The American journal of medicine 1987;82(6):1233-7.
1987: Bradley T Hyman; L J Kromer; Gary W Van Hoesen
Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease.
Annals of neurology 1987;21(3):259-67.
1986: Bradley T Hyman; Gary W Van Hoesen; L J Kromer; Antonio R Damasio
Perforant pathway changes and the memory impairment of Alzheimer's disease.
Annals of neurology 1986;20(4):472-81.
1986: Bradley T Hyman; M A Westrick
Multiple myeloma with polyneuropathy and coagulopathy. A case report of the polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin change (POEMS) syndrome.
Archives of internal medicine 1986;146(5):993-4.
1986: G W Van Hoesen; Bradley T Hyman; A R Damasio
Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease.
Progress in brain research 1986;70():321-35.
1985: Bradley T Hyman; P J Eslinger; A R Damasio
Effect of naltrexone on senile dementia of the Alzheimer type.
Journal of neurology, neurosurgery, and psychiatry 1985;48(11):1169-71.
1984: Bradley T Hyman; G W Van Hoesen; A R Damasio; C L Barnes
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Science (New York, N.Y.) 1984;225(4667):1168-70.
1983: M A Yorek; Bradley T Hyman; A A Spector
Glycine uptake by cultured human Y79 retinoblastoma cells: effect of changes in phospholipid fatty acid unsaturation.
Journal of neurochemistry 1983;40(1):70-8.
1982: Bradley T Hyman; L L Stoll; A A Spector
Prostaglandin production by 3T3-L1 cells in culture.
Biochimica et biophysica acta 1982;713(2):375-85.
1982: Bradley T Hyman; A A Spector
Choline uptake in cultured human Y79 retinoblastoma cells: effect of polyunsaturated fatty acid compositional modifications.
Journal of neurochemistry 1982;38(3):650-6.
1981: Bradley T Hyman; M H Haimann; M L Armstrong; A A Spector
Fatty acid and lipid composition of the monkey retina in diet-induced hypercholesterolemia.
Atherosclerosis 1981;40(3-4):321-8.
1981: Bradley T Hyman; L L Stoll; A A Spector
Accumulation of (n-9)-eicosatrienoic acid in confluent 3T3-L1 and 3T3 cells.
The Journal of biological chemistry 1981;256(17):8863-6.
1981: Bradley T Hyman; A A Spector
Accumulation of N-3 polyunsaturated fatty acids cultured human Y79 retinoblastoma cells.
Journal of neurochemistry 1981;37(1):60-9.
1980: A A Spector; S N Mathur; T L Kaduce; Bradley T Hyman
Lipid nutrition and metabolism of cultured mammalian cells.
Progress in lipid research 1980;19(3-4):155-86.
1977: J A Walder; Bradley T Hyman; M J Heller; R Y Shishido; I M Klotz
Reversible acylation and inhibition of aggregation of platelets by substituted maleic anhydrides.
Molecular pharmacology 1977;13(3):407-14.