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Bradley Hyman

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chen Li; Periquet Magali; Wang Xu; Negro Alessandro; McLean Pamela J; Hyman Bradley T; Feany Mel B
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
Meyer-Luehmann Melanie; Mielke Matthew; Spires-Jones Tara L; Stoothoff Will; Jones Phill; Bacskai Brian J; Hyman Bradley T
A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.
Stoothoff Will; Jones Phillip B; Spires-Jones Tara L; Joyner Daniel; Chhabra Ekta; Bercury Kathryn; Fan Zhanyun; Xie Hong; Bacskai Brian; Edd Jon; Irimia Daniel; Hyman Bradley T
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.

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All Publications

2009: Chen Li; Periquet Magali; Wang Xu; Negro Alessandro; McLean Pamela J; Hyman Bradley T; Feany Mel B
Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation.
The Journal of clinical investigation 2009;119(11):3257-65.
2009: Meyer-Luehmann Melanie; Mielke Matthew; Spires-Jones Tara L; Stoothoff Will; Jones Phill; Bacskai Brian J; Hyman Bradley T
A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(40):12636-40.
2009: Stoothoff Will; Jones Phillip B; Spires-Jones Tara L; Joyner Daniel; Chhabra Ekta; Bercury Kathryn; Fan Zhanyun; Xie Hong; Bacskai Brian; Edd Jon; Irimia Daniel; Hyman Bradley T
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.
Journal of neurochemistry 2009;111(2):417-27.
2009: Philipson Ola; Hammarström Per; Nilsson K Peter R; Portelius Erik; Olofsson Tommie; Ingelsson Martin; Hyman Bradley T; Blennow Kaj; Lannfelt Lars; Kalimo Hannu; Nilsson Lars N G
A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice.
Neurobiology of aging 2009;30(9):1393-405.
2009: Xiong Jian-Ping; Mahalingham Bhuvaneshwari; Alonso Jose Luis; Borrelli Laura Ann; Rui Xianliang; Anand Saurabh; Hyman Bradley T; Rysiok Thomas; Müller-Pompalla Dirk; Goodman Simon L; Arnaout M Amin
Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment.
The Journal of cell biology 2009;186(4):589-600.
2009: Fischl Bruce; Stevens Allison A; Rajendran Niranjini; Yeo B T Thomas; Greve Douglas N; Van Leemput Koen; Polimeni Jonathan R; Kakunoori Sita; Buckner Randy L; Pacheco Jennifer; Salat David H; Melcher Jennifer; Frosch Matthew P; Hyman Bradley T; Grant P Ellen; Rosen Bruce R; van der Kouwe André J W; Wiggins Graham C; Wald Lawrence L; Augustinack Jean C
Predicting the location of entorhinal cortex from MRI.
NeuroImage 2009;47(1):8-17.
2009: Sperling Reisa A; Laviolette Peter S; O'Keefe Kelly; O'Brien Jacqueline; Rentz Dorene M; Pihlajamaki Maija; Marshall Gad; Hyman Bradley T; Selkoe Dennis J; Hedden Trey; Buckner Randy L; Becker J Alex; Johnson Keith A
Amyloid deposition is associated with impaired default network function in older persons without dementia.
Neuron 2009;63(2):178-88.
2009: de Calignon Alix; Spires-Jones Tara L; Pitstick Rose; Carlson George A; Hyman Bradley T
Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy.
Journal of neuropathology and experimental neurology 2009;68(7):757-61.
2009: Rozkalne Anete; Spires-Jones Tara L; Stern Edward A; Hyman Bradley T
A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model.
Brain research 2009;1280():178-85.
2009: Guardia-Laguarta Cristina; Coma Mireia; Pera Marta; Clarimón Jordi; Sereno Lidia; Agulló José M; Molina-Porcel Laura; Gallardo Eduard; Deng Amy; Berezovska Oksana; Hyman Bradley T; Blesa Rafael; Gómez-Isla Teresa; Lleó Alberto
Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface.
Journal of neurochemistry 2009;110(1):220-30.
2009: Hoe Hyang-Sook; Lee Kea Joo; Carney Rosalind S E; Lee Jiyeon; Markova Alexandra; Lee Ji-Yun; Howell Brian W; Hyman Bradley T; Pak Daniel T S; Bu Guojun; Rebeck G William
Interaction of reelin with amyloid precursor protein promotes neurite outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(23):7459-73.
2009: Herl Lauren; Thomas Anne V; Lill Christina M; Banks Mary; Deng Amy; Jones Phill B; Spoelgen Robert; Hyman Bradley T; Berezovska Oksana
Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase.
Molecular and cellular neurosciences 2009;41(2):166-74.
2009: McFarland Nikolaus R; Fan Zhanyun; Xu Kui; Schwarzschild Michael A; Feany Mel B; Hyman Bradley T; McLean Pamela J
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.
Journal of neuropathology and experimental neurology 2009;68(5):515-24.
2009: Serneels Lutgarde; Van Biervliet Jérôme; Craessaerts Katleen; Dejaegere Tim; Horré Katrien; Van Houtvin Tine; Esselmann Hermann; Paul Sabine; Schäfer Martin K; Berezovska Oksana; Hyman Bradley T; Sprangers Ben; Sciot Raf; Moons Lieve; Jucker Mathias; Yang Zhixiang; May Patrick C; Karran Eric; Wiltfang Jens; D'Hooge Rudi; De Strooper Bart
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Science (New York, N.Y.) 2009;324(5927):639-42.
2009: McFarland Nikolaus R; Lee Jeng-Shin; Hyman Bradley T; McLean Pamela J
Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system.
Journal of neurochemistry 2009;109(3):838-45.
2009: Lu Alice; Hiltunen Mikko; Romano Donna M; Soininen Hilkka; Hyman Bradley T; Bertram Lars; Tanzi Rudolph E
Effects of ubiquilin 1 on the unfolded protein response.
Journal of molecular neuroscience : MN 2009;38(1):19-30.
2009: Koffie Robert M; Meyer-Luehmann Melanie; Hashimoto Tadafumi; Adams Kenneth W; Mielke Matthew L; Garcia-Alloza Monica; Micheva Kristina D; Smith Stephen J; Kim M Leo; Lee Virginia M; Hyman Bradley T; Spires-Jones Tara L
Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):4012-7.
2009: Hoe Hyang-Sook; Fu Zhanyan; Makarova Alexandra; Lee Ji-Yun; Lu Congyi; Feng Li; Pajoohesh-Ganji Ahdeah; Matsuoka Yasuji; Hyman Bradley T; Ehlers Michael D; Vicini Stefano; Pak Daniel T S; Rebeck G William
The effects of amyloid precursor protein on postsynaptic composition and activity.
The Journal of biological chemistry 2009;284(13):8495-506.
2009: Spires-Jones Tara L; Stoothoff William H; de Calignon Alix; Jones Phillip B; Hyman Bradley T
Tau pathophysiology in neurodegeneration: a tangled issue.
Trends in neurosciences 2009;32(3):150-9.
2009: Desikan R S; Cabral H J; Fischl B; Guttmann C R G; Blacker D; Hyman B T; Albert M S; Killiany R J
Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease.
AJNR. American journal of neuroradiology 2009;30(3):532-8.
2009: Dickerson Bradford C; Bakkour Akram; Salat David H; Feczko Eric; Pacheco Jenni; Greve Douglas N; Grodstein Fran; Wright Christopher I; Blacker Deborah; Rosas H Diana; Sperling Reisa A; Atri Alireza; Growdon John H; Hyman Bradley T; Morris John C; Fischl Bruce; Buckner Randy L
The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals.
Cerebral cortex (New York, N.Y. : 1991) 2009;19(3):497-510.
2009: Kuchibhotla Kishore V; Lattarulo Carli R; Hyman Bradley T; Bacskai Brian J
Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice.
Science (New York, N.Y.) 2009;323(5918):1211-5.
2009: Okereke Olivia I; Xia Weiming; Irizarry Michael C; Sun Xiaoyan; Qiu Wei Q; Fagan Anne M; Mehta Pankaj D; Hyman Bradley T; Selkoe Dennis J; Grodstein Francine
Performance characteristics of plasma amyloid-beta 40 and 42 assays.
Journal of Alzheimer's disease : JAD 2009;16(2):277-85.
2009: Spoelgen R; Adams K W; Koker M; Thomas A V; Andersen O M; Hallett P J; Bercury K K; Joyner D F; Deng M; Stoothoff W H; Strickland D K; Willnow T E; Hyman B T
Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.
Neuroscience 2009;158(4):1460-8.
2009: Spires-Jones Tara L; Mielke Matthew L; Rozkalne Anete; Meyer-Luehmann Melanie; de Calignon Alix; Bacskai Brian J; Schenk Dale; Hyman Bradley T
Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease.
Neurobiology of disease 2009;33(2):213-20.
2009: Viswanathan A; Raj S; Greenberg S M; Stampfer M; Campbell S; Hyman B T; Irizarry M C
Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial.
Neurology 2009;72(3):268-72.
2009: Uemura Kengo; Lill Christina M; Banks Mary; Asada Megumi; Aoyagi Nobuhisa; Ando Koichi; Kubota Masakazu; Kihara Takeshi; Nishimoto Takaaki; Sugimoto Hachiro; Takahashi Ryosuke; Hyman Bradley T; Shimohama Shun; Berezovska Oksana; Kinoshita Ayae
N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio.
Journal of neurochemistry 2009;108(2):350-60.
2009: Freeman Stefanie H; Hyman Bradley T; Sims Katherine B; Hedley-Whyte E T; Vossough Arastoo; Frosch Matthew P; Schmahmann Jeremy D
Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations.
Brain pathology (Zurich, Switzerland) 2009;19(1):39-47.
2009: Outeiro Tiago F; Klucken Jochen; Bercury Kathryn; Tetzlaff Julie; Putcha Preeti; Oliveira Luis M A; Quintas Alexandre; McLean Pamela J; Hyman Bradley T
Dopamine-induced conformational changes in alpha-synuclein.
PloS one 2009;4(9):e6906.
2009: Blom Elin S; Giedraitis Vilmantas; Zetterberg Henrik; Fukumoto Hiroaki; Blennow Kaj; Hyman Bradley T; Irizarry Michael C; Wahlund Lars-Olof; Lannfelt Lars; Ingelsson Martin
Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype.
Dementia and geriatric cognitive disorders 2009;27(5):458-64.
2009: Garcia-Alloza Monica; Subramanian Meenakshi; Thyssen Diana; Borrelli Laura A; Fauq Abdul; Das Pritam; Golde Todd E; Hyman Bradley T; Bacskai Brian J
Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.
Molecular neurodegeneration 2009;4():19.
2008: Koenigsknecht-Talboo Jessica; Meyer-Luehmann Melanie; Parsadanian Maia; Garcia-Alloza Monica; Finn Mary Beth; Hyman Bradley T; Bacskai Brian J; Holtzman David M
Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(52):14156-64.
2008: Mandal Asim K; Jones Phillip B; Bair Angela M; Christmas Peter; Miller Douglas; Yamin Ting-ting D; Wisniewski Douglas; Menke John; Evans Jilly F; Hyman Bradley T; Bacskai Brian; Chen Mei; Lee David M; Nikolic Boris; Soberman Roy J
The nuclear membrane organization of leukotriene synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20434-9.
2008: Freeman Stefanie H; Kandel Ruth; Cruz Luis; Rozkalne Anete; Newell Kathy; Frosch Matthew P; Hedley-Whyte E Tessa; Locascio Joseph J; Lipsitz Lewis A; Hyman Bradley T
Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease.
Journal of neuropathology and experimental neurology 2008;67(12):1205-12.
2008: Stoothoff William H; Bacskai Brian J; Hyman Bradley T
Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons.
Journal of biomedical optics 2008;13(6):064039.
2008: O'Callaghan Paul; Sandwall Elina; Li Jin-Ping; Yu Hong; Ravid Rivka; Guan Zhi-Zhong; van Kuppevelt Toin H; Nilsson Lars N G; Ingelsson Martin; Hyman Bradley T; Kalimo Hannu; Lindahl Ulf; Lannfelt Lars; Zhang Xiao
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.
Brain pathology (Zurich, Switzerland) 2008;18(4):548-61.
2008: Sundelöf J; Arnlöv J; Ingelsson E; Sundström J; Basu S; Zethelius B; Larsson A; Irizarry M C; Giedraitis V; Rönnemaa E; Degerman-Gunnarsson M; Hyman B T; Basun H; Kilander L; Lannfelt L
Serum cystatin C and the risk of Alzheimer disease in elderly men.
Neurology 2008;71(14):1072-9.
2008: Gomperts S N; Rentz D M; Moran E; Becker J A; Locascio J J; Klunk W E; Mathis C A; Elmaleh D R; Shoup T; Fischman A J; Hyman B T; Growdon J H; Johnson K A
Imaging amyloid deposition in Lewy body diseases.
Neurology 2008;71(12):903-10.
2008: Desikan R S; Fischl B; Cabral H J; Kemper T L; Guttmann C R G; Blacker D; Hyman B T; Albert M S; Killiany R J
MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD.
Neurology 2008;71(11):819-25.
2008: Makarova Alexandra; Bercury Kathryn K; Adams Kenneth W; Joyner Daniel; Deng Meihua; Spoelgen Robert; Koker Mirjam; Strickland Dudley K; Hyman Bradley T
The LDL receptor-related protein can form homo-dimers in neuronal cells.
Neuroscience letters 2008;442(2):91-5.
2008: Jones Phill B; Shin Hwa Kyoung; Boas David A; Hyman Bradley T; Moskowitz Michael A; Ayata Cenk; Dunn Andrew K
Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia.
Journal of biomedical optics 2008;13(4):044007.
2008: Kuchibhotla Kishore V; Goldman Samuel T; Lattarulo Carli R; Wu Hai-Yan; Hyman Bradley T; Bacskai Brian J
Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks.
Neuron 2008;59(2):214-25.
2008: Steinerman Joshua R; Irizarry Michael; Scarmeas Nikolaos; Raju Susan; Brandt Jason; Albert Marilyn; Blacker Deborah; Hyman Bradley; Stern Yaakov
Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study.
Archives of neurology 2008;65(7):906-12.
2008: Locascio Joseph J; Fukumoto Hiroaki; Yap Liang; Bottiglieri Teodoro; Growdon John H; Hyman Bradley T; Irizarry Michael C
Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease.
Archives of neurology 2008;65(6):776-85.
2008: Tetzlaff Julie E; Putcha Preeti; Outeiro Tiago F; Ivanov Alexander; Berezovska Oksana; Hyman Bradley T; McLean Pamela J
CHIP targets toxic alpha-Synuclein oligomers for degradation.
The Journal of biological chemistry 2008;283(26):17962-8.
2008: Khachaturian Zaven S; Petersen Ronald C; Gauthier Serge; Buckholtz Neil; Corey-Bloom Jodey P; Evans Bill; Fillit Howard; Foster Norman; Greenberg Barry; Grundman Michael; Sano Mary; Simpkins James; Schneider Lon S; Weiner Michael W; Galasko Doug; Hyman Bradley; Kuller Lew; Schenk Dale; Snyder Stephen; Thomas Ronald G; Tuszynski Mark H; Vellas Bruno; Wurtman Richard J; Snyder Peter J; Frank Richard A; Albert Marilyn; Doody Rachelle; Ferris Steven; Kaye Jeffrey; Koo Edward; Morrison-Bogorad Marcelle; Reisberg Barry; Salmon David P; Gilman Sid; Mohs Richard; Aisen Paul S; Breitner John C S; Cummings Jeffrey L; Kawas Claudia; Phelps Creighton; Poirier Judes; Sabbagh Marwan; Touchon Jacques; Khachaturian Ara S; Bain Lisa J
A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium.
Alzheimer's & dementia : the journal of the Alzheimer's Association 2008;4(3):156-63.
2008: Thomas Anne V; Berezovska Oksana; Hyman Bradley T; von Arnim Christine A F
Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells.
Methods (San Diego, Calif.) 2008;44(4):299-303.
2008: Yacoubian Talene A; Cantuti-Castelvetri Ippolita; Bouzou Bérengère; Asteris Georgios; McLean Pamela J; Hyman Bradley T; Standaert David G
Transcriptional dysregulation in a transgenic model of Parkinson disease.
Neurobiology of disease 2008;29(3):515-28.
2008: Hoe Hyang-Sook; Minami S Sakura; Makarova Alexandra; Lee Jiyeon; Hyman Bradley T; Matsuoka Yasuji; Rebeck G William
Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing.
The Journal of biological chemistry 2008;283(10):6288-99.
2008: Sundelöf Johan; Giedraitis Vilmantas; Irizarry Michael C; Sundström Johan; Ingelsson Erik; Rönnemaa Elina; Arnlöv Johan; Gunnarsson Malin Degerman; Hyman Bradley T; Basun Hans; Ingelsson Martin; Lannfelt Lars; Kilander Lena
Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study.
Archives of neurology 2008;65(2):256-63.
2008: Meyer-Luehmann Melanie; Spires-Jones Tara L; Prada Claudia; Garcia-Alloza Monica; de Calignon Alix; Rozkalne Anete; Koenigsknecht-Talboo Jessica; Holtzman David M; Bacskai Brian J; Hyman Bradley T
Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease.
Nature 2008;451(7179):720-4.
2008: Jones Phillip B; Rozkalne Aneta; Meyer-Luehmann Melanie; Spires-Jones Tara L; Makarova Alexandra; Kumar Anand T N; Berezovska Oksana; Bacskai Brian B; Hyman Bradley T
Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy.
Journal of biomedical optics 2008;13(1):014008.
2008: Spires-Jones Tara L; de Calignon Alix; Matsui Toshifumi; Zehr Cindy; Pitstick Rose; Wu Hai-Yan; Osetek Jennifer D; Jones Phillip B; Bacskai Brian J; Feany Mel B; Carlson George A; Ashe Karen H; Lewis Jada; Hyman Bradley T
In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(4):862-7.
2008: Freeman Stefanie H; Spires-Jones Tara; Hyman Bradley T; Growdon John H; Frosch Matthew P
TAR-DNA binding protein 43 in Pick disease.
Journal of neuropathology and experimental neurology 2008;67(1):62-7.
2008: Grodstein Francine; van Oijen Marieke; Irizarry Michael C; Rosas H Diana; Hyman Bradley T; Growdon John H; De Vivo Immaculata
Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study.
PloS one 2008;3(2):e1590.
2008: Hyman Bradley
In reply to Zou et al. "New amyloid plaques or a game of hide-and-seek?".
International journal of biological sciences 2008;4(4):245.
2008: Gomez-Isla Teresa; Spires Tara; De Calignon Alix; Hyman Bradley T
Neuropathology of Alzheimer's disease.
Handbook of clinical neurology / edited by P.J. Vinken and G.W. Bruyn 2008;89():233-43.
2008: Outeiro Tiago Fleming; Putcha Preeti; Tetzlaff Julie E; Spoelgen Robert; Koker Mirjam; Carvalho Filipe; Hyman Bradley T; McLean Pamela J
Formation of toxic oligomeric alpha-synuclein species in living cells.
PloS one 2008;3(4):e1867.
2007: Dickerson Bradford C; Sperling Reisa A; Hyman Bradley T; Albert Marilyn S; Blacker Deborah
Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment.
Archives of general psychiatry 2007;64(12):1443-50.
2007: Garcia-Alloza Monica; Ferrara Brian J; Dodwell Sarah A; Hickey Gregory A; Hyman Bradley T; Bacskai Brian J
A limited role for microglia in antibody mediated plaque clearance in APP mice.
Neurobiology of disease 2007;28(3):286-92.
2007: Giedraitis Vilmantas; Sundelöf Johan; Irizarry Michael C; Gårevik Nina; Hyman Bradley T; Wahlund Lars-Olof; Ingelsson Martin; Lannfelt Lars
The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease.
Neuroscience letters 2007;427(3):127-31.
2007: Grammatopoulos Tom N; Outeiro Tiago F; Hyman Bradley T; Standaert David G
Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro.
Biochemical and biophysical research communications 2007;363(3):846-51.
2007: Conrad Chris; Zhu Jun; Conrad Cintia; Schoenfeld David; Fang Zhide; Ingelsson Martin; Stamm Stefan; Church George; Hyman Bradley T
Single molecule profiling of tau gene expression in Alzheimer's disease.
Journal of neurochemistry 2007;103(3):1228-36.
2007: Ingelsson Martin; Ramasamy Karunya; Russ Carsten; Freeman Stefanie H; Orne Jennifer; Raju Susan; Matsui Toshifumi; Growdon John H; Frosch Matthew P; Ghetti Bernardino; Brown Robert H; Irizarry Michael C; Hyman Bradley T
Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains.
Acta neuropathologica 2007;114(5):471-9.
2007: Spires-Jones Tara L; Meyer-Luehmann Melanie; Osetek Jennifer D; Jones Phillip B; Stern Edward A; Bacskai Brian J; Hyman Bradley T
Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model.
The American journal of pathology 2007;171(4):1304-11.
2007: Shin Hwa Kyoung; Jones Phillip B; Garcia-Alloza Monica; Borrelli Laura; Greenberg Steven M; Bacskai Brian J; Frosch Matthew P; Hyman Bradley T; Moskowitz Michael A; Ayata Cenk
Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy.
Brain : a journal of neurology 2007;130(Pt 9):2310-9.
2007: Matsui Toshifumi; Ingelsson Martin; Fukumoto Hiroaki; Ramasamy Karunya; Kowa Hisatomo; Frosch Matthew P; Irizarry Michael C; Hyman Bradley T
Expression of APP pathway mRNAs and proteins in Alzheimer's disease.
Brain research 2007;1161():116-23.
2007: Garcia-Alloza M; Borrelli L A; Rozkalne A; Hyman B T; Bacskai B J
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.
Journal of neurochemistry 2007;102(4):1095-104.
2007: Outeiro Tiago Fleming; Kontopoulos Eirene; Altmann Stephen M; Kufareva Irina; Strathearn Katherine E; Amore Allison M; Volk Catherine B; Maxwell Michele M; Rochet Jean-Christophe; McLean Pamela J; Young Anne B; Abagyan Ruben; Feany Mel B; Hyman Bradley T; Kazantsev Aleksey G
Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease.
Science (New York, N.Y.) 2007;317(5837):516-9.
2007: Outeiro Tiago Fleming; Grammatopoulos Tom N; Altmann Steven; Amore Allison; Standaert David G; Hyman Bradley T; Kazantsev Aleksey G
Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
Biochemical and biophysical research communications 2007;357(3):596-602.
2007: Spires Tara L; Hyman Bradley T
Spine tingling polymorphisms--is apolipoprotein E involved in dendritic shape and plasticity?
Neurobiology of aging 2007;28(5):687-8; discussion 704-6.
2007: Freeman Stefanie H; Raju Susan; Hyman Bradley T; Frosch Matthew P; Irizarry Michael C
Plasma Abeta levels do not reflect brain Abeta levels.
Journal of neuropathology and experimental neurology 2007;66(4):264-71.
2007: Bacskai Brian J; Frosch Matthew P; Freeman Stefanie H; Raymond Scott B; Augustinack Jean C; Johnson Keith A; Irizarry Michael C; Klunk William E; Mathis Chester A; Dekosky Steven T; Greenberg Steven M; Hyman Bradley T; Growdon John H
Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report.
Archives of neurology 2007;64(3):431-4.
2007: Kim Minji; Hersh Louis B; Leissring Malcolm A; Ingelsson Martin; Matsui Toshifumi; Farris Wesley; Lu Alice; Hyman Bradley T; Selkoe Dennis J; Bertram Lars; Tanzi Rudolph E
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
The Journal of biological chemistry 2007;282(11):7825-32.
2007: St Martin Jessie L; Klucken Jochen; Outeiro Tiago F; Nguyen Paul; Keller-McGandy Christine; Cantuti-Castelvetri Ippolita; Grammatopoulos Tom N; Standaert David G; Hyman Bradley T; McLean Pamela J
Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
Journal of neurochemistry 2007;100(6):1449-57.
2007: Fulga Tudor A; Elson-Schwab Ilan; Khurana Vikram; Steinhilb Michelle L; Spires Tara L; Hyman Bradley T; Feany Mel B
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
Nature cell biology 2007;9(2):139-48.
2007: Irizarry M C; Yao Y; Hyman B T; Growdon J H; Praticò D
Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease.
Neuro-degenerative diseases 2007;4(6):403-5.
2006: Outeiro Tiago Fleming; Klucken Jochen; Strathearn Katherine E; Liu Fang; Nguyen Paul; Rochet Jean-Christophe; Hyman Bradley T; McLean Pamela J
Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation.
Biochemical and biophysical research communications 2006;351(3):631-8.
2006: Garcia-Alloza Monica; Dodwell Sarah A; Meyer-Luehmann Melanie; Hyman Bradley T; Bacskai Brian J
Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model.
Journal of neuropathology and experimental neurology 2006;65(11):1082-9.
2006: Hyman Bradley T
The natural history of Alzheimer disease dissected through multiphoton imaging of transgenic mice.
Alzheimer disease and associated disorders 2006;20(4):206-9.
2006: Klucken Jochen; Outeiro Tiago F; Nguyen Paul; McLean Pamela J; Hyman Bradley T
Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(12):2050-7.
2006: Hiltunen Mikko; Lu Alice; Thomas Anne V; Romano Donna M; Kim Minji; Jones Phill B; Xie Zhongcong; Kounnas Maria Z; Wagner Steven L; Berezovska Oksana; Hyman Bradley T; Tesco Giuseppina; Bertram Lars; Tanzi Rudolph E
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion.
The Journal of biological chemistry 2006;281(43):32240-53.
2006: Peltan Ithan D; Thomas Anne V; Mikhailenko Irina; Strickland Dudley K; Hyman Bradley T; von Arnim Christine A F
Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons.
Biochemical and biophysical research communications 2006;349(1):24-30.
2006: Ingelsson Martin; Ramasamy Karunya; Cantuti-Castelvetri Ippolita; Skoglund Lena; Matsui Toshifumi; Orne Jennifer; Kowa Hasimoto; Raju Susan; Vanderburg Charles R; Augustinack Jean C; de Silva Rohan; Lees Andrew J; Lannfelt Lars; Growdon John H; Frosch Matthew P; Standaert David G; Irizarry Michael C; Hyman Bradley T
No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain.
Acta neuropathologica 2006;112(4):439-49.
2006: Jones Phill B; Herl Lauren; Berezovska Oksana; Kumar Anand T N; Bacskai Brian J; Hyman Bradley T
Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays.
Journal of biomedical optics 2006;11(5):054024.
2006: von Arnim Christine A F; Spoelgen Robert; Peltan Ithan D; Deng Meihua; Courchesne Stephanie; Koker Mirjam; Matsui Toshifumi; Kowa Hisatomo; Lichtenthaler Stefan F; Irizarry Michael C; Hyman Bradley T
GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(39):9913-22.
2006: Sever Sanja; Skoch Jesse; Newmyer Sherri; Ramachandran Rajesh; Ko David; McKee Mary; Bouley Richard; Ausiello Dennis; Hyman Bradley T; Bacskai Brian J
Physical and functional connection between auxilin and dynamin during endocytosis.
The EMBO journal 2006;25(18):4163-74.
2006: Thomas Anne V; Herl Lauren; Spoelgen Robert; Hiltunen Mikko; Jones Phill B; Tanzi Rudolph E; Hyman Bradley T; Berezovska Oksana
Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader.
The Journal of biological chemistry 2006;281(36):26400-7.
2006: Xiong Ying; Cao Chunzhang; Makarova Alexandra; Hyman Brad; Zhang Li
Mac-1 promotes FcgammaRIIA-dependent cell spreading and migration on immune complexes.
Biochemistry 2006;45(29):8721-31.
2006: Hyman Bradley T; Growdon John H
Can the immune system fight Alzheimer disease?
Nature medicine 2006;12(7):755-6; discussion 756.
2006: Desikan Rahul S; Ségonne Florent; Fischl Bruce; Quinn Brian T; Dickerson Bradford C; Blacker Deborah; Buckner Randy L; Dale Anders M; Maguire R Paul; Hyman Bradley T; Albert Marilyn S; Killiany Ronald J
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest.
NeuroImage 2006;31(3):968-80.
2006: Matsui Toshifumi; Ramasamy Karunya; Ingelsson Martin; Fukumoto Hiroaki; Conrad Cintia; Frosch Matthew P; Irizarry Michael C; Yuan Junying; Hyman Bradley T
Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels.
Journal of neuropathology and experimental neurology 2006;65(5):508-15.
2006: Spires Tara L; Orne Jennifer D; SantaCruz Karen; Pitstick Rose; Carlson George A; Ashe Karen H; Hyman Bradley T
Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy.
The American journal of pathology 2006;168(5):1598-607.
2006: Cao Chunzhang; Lawrence Daniel A; Li Yang; Von Arnim Christine A F; Herz Joachim; Su Enming J; Makarova Alexandra; Hyman Bradley T; Strickland Dudley K; Zhang Li
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.
The EMBO journal 2006;25(9):1860-70.
2006: Hallett Penelope J; Spoelgen Robert; Hyman Bradley T; Standaert David G; Dunah Anthone W
Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(17):4690-700.
2006: Bodner Ruth A; Outeiro Tiago Fleming; Altmann Stephen; Maxwell Michele M; Cho Stephanie H; Hyman Bradley T; McLean Pamela J; Young Anne B; Housman David E; Kazantsev Aleksey G
Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(11):4246-51.
2006: Andersen Olav M; Schmidt Vanessa; Spoelgen Robert; Gliemann Jørgen; Behlke Joachim; Galatis Denise; McKinstry William J; Parker Michael W; Masters Colin L; Hyman Bradley T; Cappai Roberto; Willnow Thomas E
Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11.
Biochemistry 2006;45(8):2618-28.
2006: Klucken J; Ingelsson M; Shin Y; Irizarry M C; Hedley-Whyte E T; Frosch M; Growdon J; McLean Pamela; Hyman Bradley T
Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies.
Acta neuropathologica 2006;111(2):101-8.
2006: Holtzer Roee; Irizarry Michael C; Sanders Jody; Hyman Bradley T; Wegesin Domonick J; Riba Aliza; Brandt Jason; Albert Marilyn; Stern Yaakov
Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease.
Archives of neurology 2006;63(2):226-30.
2006: Herl Lauren; Lleo Alberto; Thomas Anne V; Nyborg Andrew C; Jansen Karen; Golde Todd E; Hyman Bradley T; Berezovska Oksana
Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy.
Biochemical and biophysical research communications 2006;340(2):668-74.
2006: Spoelgen Robert; von Arnim Christine A F; Thomas Anne V; Peltan Ithan D; Koker Mirjam; Deng Amy; Irizarry Michael C; Andersen Olav M; Willnow Thomas E; Hyman Bradley T
Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):418-28.
2006: Robbins Elissa M; Betensky Rebecca A; Domnitz Sarah B; Purcell Susan M; Garcia-Alloza Monica; Greenberg Charles; Rebeck G William; Hyman Bradley T; Greenberg Steven M; Frosch Matthew P; Bacskai Brian J
Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(2):365-71.
2006: Nyborg Andrew C; Herl Lauren; Berezovska Oksana; Thomas Anne V; Ladd Thomas B; Jansen Karen; Hyman Bradley T; Golde Todd E
Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells.
Molecular neurodegeneration 2006;1():16.
2006: Skoch Jesse; Hyman Bradley T; Bacskai Brian J
Preclinical characterization of amyloid imaging probes with multiphoton microscopy.
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):401-7.
2006: Broekman M L D; Comer L A; Hyman B T; Sena-Esteves M
Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain.
Neuroscience 2006;138(2):501-10.
2005: Cantuti-Castelvetri Ippolita; Klucken Jochen; Ingelsson Martin; Ramasamy Karunya; McLean Pamela J; Frosch Matthew P; Hyman Bradley T; Standaert David G
Alpha-synuclein and chaperones in dementia with Lewy bodies.
Journal of neuropathology and experimental neurology 2005;64(12):1058-66.
2005: Xiang Zhongmin; Nesterov Evgueni E; Skoch Jesse; Lin Tong; Hyman Bradley T; Swager Timothy M; Bacskai Brian J; Reeves Steven A
Detection of myelination using a novel histological probe.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2005;53(12):1511-6.
2005: Irizarry M C; Gurol M E; Raju S; Diaz-Arrastia R; Locascio J J; Tennis M; Hyman B T; Growdon J H; Greenberg S M; Bottiglieri T
Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease.
Neurology 2005;65(9):1402-8.
2005: Tesco Giuseppina; Ginestroni Andrea; Hiltunen Mikko; Kim Minji; Dolios Georgia; Hyman Bradley T; Wang Rong; Berezovska Oksana; Tanzi Rudolph E
APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation.
Journal of neurochemistry 2005;95(2):446-56.
2005: Andersen Olav M; Reiche Juliane; Schmidt Vanessa; Gotthardt Michael; Spoelgen Robert; Behlke Joachim; von Arnim Christine A F; Breiderhoff Tilman; Jansen Pernille; Wu Xin; Bales Kelly R; Cappai Roberto; Masters Colin L; Gliemann Jørgen; Mufson Elliott J; Hyman Bradley T; Paul Steven M; Nykjaer Anders; Willnow Thomas E
Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13461-6.
2005: Koh Young Ho; von Arnim Christine A F; Hyman Bradley T; Tanzi Rudolph E; Tesco Giuseppina
BACE is degraded via the lysosomal pathway.
The Journal of biological chemistry 2005;280(37):32499-504.
2005: Spires Tara L; Meyer-Luehmann Melanie; Stern Edward A; McLean Pamela J; Skoch Jesse; Nguyen Paul T; Bacskai Brian J; Hyman Bradley T
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(31):7278-87.
2005: Nesterov Evgueni E; Skoch Jesse; Hyman Bradley T; Klunk William E; Bacskai Brian J; Swager Timothy M
In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers.
Angewandte Chemie (International ed. in English) 2005;44(34):5452-6.
2005: Ruiz Jose; Kouiavskaia Diana; Migliorini Molly; Robinson Susan; Saenko Evgueni L; Gorlatova Natalia; Li Donghua; Lawrence Daniel; Hyman Bradley T; Weisgraber Karl H; Strickland Dudley K
The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.
Journal of lipid research 2005;46(8):1721-31.
2005: Spires Tara L; Hyman Bradley T
Transgenic models of Alzheimer's disease: learning from animals.
NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics 2005;2(3):423-37.
2005: Domnitz Sarah B; Robbins Elissa M; Hoang Alex W; Garcia-Alloza Monica; Hyman Bradley T; Rebeck G William; Greenberg Steven M; Bacskai Brian J; Frosch Matthew P
Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease.
Journal of neuropathology and experimental neurology 2005;64(7):588-94.
2005: Santacruz K; Lewis J; Spires T; Paulson J; Kotilinek L; Ingelsson M; Guimaraes A; DeTure M; Ramsden M; McGowan E; Forster C; Yue M; Orne J; Janus C; Mariash A; Kuskowski M; Hyman B; Hutton M; Ashe K H
Tau suppression in a neurodegenerative mouse model improves memory function.
Science (New York, N.Y.) 2005;309(5733):476-81.
2005: Lleó Alberto; Waldron Elaine; von Arnim Christine A F; Herl Lauren; Tangredi Michele M; Peltan Ithan D; Strickland Dudley K; Koo Edward H; Hyman Bradley T; Pietrzik Claus U; Berezovska Oksana
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.
The Journal of biological chemistry 2005;280(29):27303-9.
2005: Lee Jung; Fukumoto Hiroaki; Orne Jennifer; Klucken Jochen; Raju Susan; Vanderburg Charles R; Irizarry Michael C; Hyman Bradley T; Ingelsson Martin
Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms.
Experimental neurology 2005;194(1):91-6.
2005: Shin Youngah; Klucken Jochen; Patterson Cam; Hyman Bradley T; McLean Pamela J
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways.
The Journal of biological chemistry 2005;280(25):23727-34.
2005: von Arnim Christine A F; Kinoshita Ayae; Peltan Ithan D; Tangredi Michelle M; Herl Lauren; Lee Bonny M; Spoelgen Robert; Hshieh Tammy T; Ranganathan Sripriya; Battey Frances D; Liu Chun-Xiang; Bacskai Brian J; Sever Sanja; Irizarry Michael C; Strickland Dudley K; Hyman Bradley T
The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
The Journal of biological chemistry 2005;280(18):17777-85.
2005: Moir Robert D; Tseitlin Katya A; Soscia Stephanie; Hyman Bradley T; Irizarry Michael C; Tanzi Rudolph E
Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients.
The Journal of biological chemistry 2005;280(17):17458-63.
2005: Berezovska Oksana; Lleo Alberto; Herl Lauren D; Frosch Matthew P; Stern Edward A; Bacskai Brian J; Hyman Bradley T
Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(11):3009-17.
2005: Bertram Lars; Hiltunen Mikko; Parkinson Michele; Ingelsson Martin; Lange Christoph; Ramasamy Karunya; Mullin Kristina; Menon Rashmi; Sampson Andrew J; Hsiao Monica Y; Elliott Kathryn J; Velicelebi Gonül; Moscarillo Thomas; Hyman Bradley T; Wagner Steven L; Becker K David; Blacker Deborah; Tanzi Rudolph E
Family-based association between Alzheimer's disease and variants in UBQLN1.
The New England journal of medicine 2005;352(9):884-94.
2005: Brendza Robert P; Bacskai Brian J; Cirrito John R; Simmons Kelly A; Skoch Jesse M; Klunk William E; Mathis Chester A; Bales Kelly R; Paul Steven M; Hyman Bradley T; Holtzman David M
Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice.
The Journal of clinical investigation 2005;115(2):428-33.
2005: Skoch Jesse; Dunn Andrew; Hyman Bradley T; Bacskai Brian J
Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology.
Journal of biomedical optics 2005;10(1):11007.
2005: Hyman Bradley T; Augustinack Jean C; Ingelsson Martin
Transcriptional and conformational changes of the tau molecule in Alzheimer's disease.
Biochimica et biophysica acta 2005;1739(2-3):150-7.
2005: Skoch Jesse; Hickey Gregory A; Kajdasz Stephen T; Hyman Bradley T; Bacskai Brian J
In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy.
Methods in molecular biology (Clifton, N.J.) 2005;299():349-63.
2004: Klucken Jochen; Shin Youngah; Hyman Bradley T; McLean Pamela J
A single amino acid substitution differentiates Hsp70-dependent effects on alpha-synuclein degradation and toxicity.
Biochemical and biophysical research communications 2004;325(1):367-73.
2004: von Arnim Christine A F; Tangredi Michelle M; Peltan Ithan D; Lee Bonny M; Irizarry Michael C; Kinoshita Ayae; Hyman Bradley T
Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
Journal of cell science 2004;117(Pt 22):5437-45.
2004: Lleó Alberto; Berezovska Oksana; Herl Lauren; Raju Susan; Deng Amy; Bacskai Brian J; Frosch Matthew P; Irizarry Michael; Hyman Bradley T
Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation.
Nature medicine 2004;10(10):1065-6.
2004: Ingelsson Martin; Jesneck Jennifer; Irizarry Michael C; Hyman Bradley T; Rebeck G William
Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer's disease.
Neuroscience letters 2004;367(2):228-31.
2004: Irizarry Michael C; Deng Amy; Lleo Alberto; Berezovska Oksana; Von Arnim Christine A F; Martin-Rehrmann Matthew; Manelli Arlene; LaDu Mary Jo; Hyman Bradley T; Rebeck G William
Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein.
Journal of neurochemistry 2004;90(5):1132-43.
2004: Ranganathan Sripriya; Liu Chun-Xiang; Migliorini Mary M; Von Arnim Christine A F; Peltan Ithan D; Mikhailenko Irina; Hyman Bradley T; Strickland Dudley K
Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules.
The Journal of biological chemistry 2004;279(39):40536-44.
2004: McLean Pamela J; Klucken Jochen; Shin Youngah; Hyman Bradley T
Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro.
Biochemical and biophysical research communications 2004;321(3):665-9.
2004: Green Pattie S; Mendez Armando J; Jacob Jason S; Crowley Jan R; Growdon Whit; Hyman Bradley T; Heinecke Jay W
Neuronal expression of myeloperoxidase is increased in Alzheimer's disease.
Journal of neurochemistry 2004;90(3):724-33.
2004: Qiu Zhihua; Hyman Bradley T; Rebeck G William
Apolipoprotein E receptors mediate neurite outgrowth through activation of p44/42 mitogen-activated protein kinase in primary neurons.
The Journal of biological chemistry 2004;279(33):34948-56.
2004: Pasinelli Piera; Belford Mary Elizabeth; Lennon Niall; Bacskai Brian J; Hyman Bradley T; Trotti Davide; Brown Robert H
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria.
Neuron 2004;43(1):19-30.
2004: Klucken Jochen; Shin Youngah; Masliah Eliezer; Hyman Bradley T; McLean Pamela J
Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity.
The Journal of biological chemistry 2004;279(24):25497-502.
2004: Stern Edward A; Bacskai Brian J; Hickey Gregory A; Attenello Frank J; Lombardo Julianne A; Hyman Bradley T
Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(19):4535-40.
2004: Mandal Asim K; Skoch Jesse; Bacskai Brian J; Hyman Bradley T; Christmas Peter; Miller Douglas; Yamin Ting-ting D; Xu Shihua; Wisniewski Douglas; Evans Jilly F; Soberman Roy J
The membrane organization of leukotriene synthesis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6587-92.
2004: Ingelsson M; Fukumoto H; Newell K L; Growdon J H; Hedley-Whyte E T; Frosch M P; Albert M S; Hyman B T; Irizarry M C
Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain.
Neurology 2004;62(6):925-31.
2004: Lleó Alberto; Berezovska Oksana; Growdon John H; Hyman Bradley T
Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2004;12(2):146-56.
2004: Fukumoto Hiroaki; Rosene Douglas L; Moss Mark B; Raju Susan; Hyman Bradley T; Irizarry Michael C
Beta-secretase activity increases with aging in human, monkey, and mouse brain.
The American journal of pathology 2004;164(2):719-25.
2004: Spires Tara L; Hyman Bradley T
Neuronal structure is altered by amyloid plaques.
Reviews in the neurosciences 2004;15(4):267-78.
2003: Lennon Niall J; Kho Alvin; Bacskai Brian J; Perlmutter Sarah L; Hyman Bradley T; Brown Robert H
Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing.
The Journal of biological chemistry 2003;278(50):50466-73.
2003: Ingelsson Martin; Shin Youngah; Irizarry Michael C; Hyman Bradley T; Lilius Lena; Forsell Charlotte; Graff Caroline
Genotyping of apolipoprotein E: comparative evaluation of different protocols.
Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.] 2003;Chapter 9():Unit9.14.
2003: Klunk William E; Engler Henry; Nordberg Agneta; Bacskai Brian J; Wang Yanming; Price Julie C; Bergström Mats; Hyman Bradley T; Långström Bengt; Mathis Chester A
Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography.
Neuroimaging clinics of North America 2003;13(4):781-9, ix.
2003: Lombardo Julianne A; Stern Edward A; McLellan Megan E; Kajdasz Stephen T; Hickey Gregory A; Bacskai Brian J; Hyman Bradley T
Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(34):10879-83.
2003: Ramdya Pavan; Skoch Jesse; Bacskai Brian J; Hyman Bradley T; Berezovska Oksana
Activated Notch1 associates with a presenilin-1/gamma-secretase docking site.
Journal of neurochemistry 2003;87(4):843-50.
2003: Klucken J; McLean P J; Gomez-Tortosa E; Ingelsson M; Hyman Bradley T
Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies.
Neurochemical research 2003;28(11):1683-91.
2003: Lleó Alberto; Berezovska Oksana; Ramdya Pavan; Fukumoto Hiroaki; Raju Susan; Shah Tejal; Hyman Bradley T
Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.
The Journal of biological chemistry 2003;278(48):47370-5.
2003: Bacskai Brian J; Hickey Gregory A; Skoch Jesse; Kajdasz Stephen T; Wang Yanming; Huang Guo-Feng; Mathis Chester A; Klunk William E; Hyman Bradley T
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12462-7.
2003: Das Chittaranjan; Berezovska Oksana; Diehl Thekla S; Genet Cedric; Buldyrev Ilya; Tsai Jui-Yi; Hyman Bradley T; Wolfe Michael S
Designed helical peptides inhibit an intramembrane protease.
Journal of the American Chemical Society 2003;125(39):11794-5.
2003: Kinoshita Ayae; Shah Tejal; Tangredi Michelle M; Strickland Dudley K; Hyman Bradley T
The intracellular domain of the low density lipoprotein receptor-related protein modulates transactivation mediated by amyloid precursor protein and Fe65.
The Journal of biological chemistry 2003;278(42):41182-8.
2003: Fukumoto Hiroaki; Ingelsson Martin; Gårevik Nina; Wahlund Lars Olof; Nukina Nobuyuki; Yaguchi Yoshio; Shibata Masao; Hyman Bradley T; Rebeck G William; Irizarry Michael C
APOE epsilon 3/ epsilon 4 heterozygotes have an elevated proportion of apolipoprotein E4 in cerebrospinal fluid relative to plasma, independent of Alzheimer's disease diagnosis.
Experimental neurology 2003;183(1):249-53.
2003: Irizarry Michael C; Hyman Bradley T
Brain isoprostanes: a marker of lipid peroxidation and oxidative stress in AD.
Neurology 2003;61(4):436-7.
2003: Kinoshita Ayae; Fukumoto Hiroaki; Shah Tejal; Whelan Christa M; Irizarry Michael C; Hyman Bradley T
Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.
Journal of cell science 2003;116(Pt 16):3339-46.
2003: Atiya Monika; Hyman Bradley T; Albert Marilyn S; Killiany Ronald
Structural magnetic resonance imaging in established and prodromal Alzheimer disease: a review.
Alzheimer disease and associated disorders 2003;17(3):177-95.
2003: Bacskai Brian J; Skoch Jesse; Hickey Gregory A; Allen Racquel; Hyman Bradley T
Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques.
Journal of biomedical optics 2003;8(3):368-75.
2003: Fukumoto Hiroaki; Tennis Marsha; Locascio Joseph J; Hyman Bradley T; Growdon John H; Irizarry Michael C
Age but not diagnosis is the main predictor of plasma amyloid beta-protein levels.
Archives of neurology 2003;60(7):958-64.
2003: Berezovska Oksana; Bacskai Brian J; Hyman Bradley T
Monitoring proteins in intact cells.
Science of aging knowledge environment : SAGE KE 2003;2003(23):PE14.
2003: Berezovska Oksana; Ramdya Pavan; Skoch Jesse; Wolfe Michael S; Bacskai Brian J; Hyman Bradley T
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(11):4560-6.
2003: Dombeck Daniel A; Kasischke Karl A; Vishwasrao Harshad D; Ingelsson Martin; Hyman Bradley T; Webb Watt W
Uniform polarity microtubule assemblies imaged in native brain tissue by second-harmonic generation microscopy.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7081-6.
2003: Zipfel Warren R; Williams Rebecca M; Christie Richard; Nikitin Alexander Yu; Hyman Bradley T; Webb Watt W
Live tissue intrinsic emission microscopy using multiphoton-excited native fluorescence and second harmonic generation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(12):7075-80.
2003: Peng S; Urbanc B; Cruz L; Hyman B T; Stanley H E
Neuron recognition by parallel Potts segmentation.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):3847-52.
2003: Greenberg S M; Bacskai B J; Hyman B T
Alzheimer disease's double-edged vaccine.
Nature medicine 2003;9(4):389-90.
2003: McLellan Megan E; Kajdasz Stephen T; Hyman Bradley T; Bacskai Brian J
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(6):2212-7.
2003: Gomez-Isla Teresa; Irizarry Michael C; Mariash Ami; Cheung Bonnie; Soto Oscar; Schrump Stefanie; Sondel Jesse; Kotilinek Linda; Day John; Schwarzschild Michael A; Cha Jang-Ho J; Newell Kathy; Miller David W; Uéda Kenji; Young Anne B; Hyman Bradley T; Ashe Karen H
Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice.
Neurobiology of aging 2003;24(2):245-58.
2003: D'Amore J D; Kajdasz S T; McLellan M E; Bacskai B J; Stern E A; Hyman B T
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Journal of neuropathology and experimental neurology 2003;62(2):137-45.
2003: Micchelli Craig A; Esler William P; Kimberly W Taylor; Jack Christine; Berezovska Oksana; Kornilova Anna; Hyman Bradley T; Perrimon Norbert; Wolfe Michael S
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):79-81.
2003: Qiu Z; Crutcher K A; Hyman B T; Rebeck G W
ApoE isoforms affect neuronal N-methyl-D-aspartate calcium responses and toxicity via receptor-mediated processes.
Neuroscience 2003;122(2):291-303.
2002: McLean Pamela J; Kawamata Hibiki; Shariff Saadat; Hewett Jeffrey; Sharma Nutan; Ueda Kenji; Breakefield Xandra O; Hyman Bradley T
TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation.
Journal of neurochemistry 2002;83(4):846-54.
2002: Le Dean A; Wu Yongqin; Huang Zhihong; Matsushita Kohji; Plesnila Nikolaus; Augustinack Jean C; Hyman Bradley T; Yuan Junying; Kuida Keisuke; Flavell Richard A; Moskowitz Michael A
Caspase activation and neuroprotection in caspase-3- deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(23):15188-93.
2002: Urbanc B; Cruz L; Le R; Sanders J; Ashe K Hsiao; Duff K; Stanley H E; Irizarry M C; Hyman B T
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):13990-5.
2002: Bacskai Brian J; Hyman Bradley T
Alzheimer's disease: what multiphoton microscopy teaches us.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2002;8(5):386-90.
2002: Cheng Leo Ling; Newell Kathy; Mallory Amy E; Hyman Bradley T; Gonzalez R Gilberto
Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology.
Magnetic resonance imaging 2002;20(7):527-33.
2002: Klunk William E; Bacskai Brian J; Mathis Chester A; Kajdasz Stephen T; McLellan Megan E; Frosch Matthew P; Debnath Manik L; Holt Daniel P; Wang Yanming; Hyman Bradley T
Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative.
Journal of neuropathology and experimental neurology 2002;61(9):797-805.
2002: Bacskai Brian J; Kajdasz Stephen T; McLellan Megan E; Games Dora; Seubert Peter; Schenk Dale; Hyman Bradley T
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(18):7873-8.
2002: Fukumoto Hiroaki; Cheung Bonnie S; Hyman Bradley T; Irizarry Michael C
Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease.
Archives of neurology 2002;59(9):1381-9.
2002: Bacskai Brian J; Klunk William E; Mathis Chester A; Hyman Bradley T
Imaging amyloid-beta deposits in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(9):1035-41.
2002: Kinoshita A; Whelan C M; Smith C J; Berezovska O; Hyman B T
Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus.
Journal of neurochemistry 2002;82(4):839-47.
2002: Guénette Suzanne Y; Chang Yang; Hyman Bradley T; Tanzi Rudolph E; Rebeck G William
Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1.
Journal of neurochemistry 2002;82(4):755-62.
2002: Kotilinek Linda A; Bacskai Brian; Westerman Marcus; Kawarabayashi Takeshi; Younkin Linda; Hyman Bradley T; Younkin Steven; Ashe Karen H
Reversible memory loss in a mouse transgenic model of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(15):6331-5.
2002: Kinoshita Ayae; Whelan Christa M; Berezovska Oksana; Hyman Bradley T
The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
The Journal of biological chemistry 2002;277(32):28530-6.
2002: Arélin Katrin; Kinoshita Ayae; Whelan Christa M; Irizarry Michael C; Rebeck G William; Strickland Dudley K; Hyman Bradley T
LRP and senile plaques in Alzheimer's disease: colocalization with apolipoprotein E and with activated astrocytes.
Brain research. Molecular brain research 2002;104(1):38-46.
2002: Augustinack Jean C; Sanders Judith L; Tsai Li-Huei; Hyman Bradley T
Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles.
Journal of neuropathology and experimental neurology 2002;61(6):557-64.
2002: Schlossmacher Michael G; Frosch Matthew P; Gai Wei Ping; Medina Miguel; Sharma Nutan; Forno Lysia; Ochiishi Tomoyo; Shimura Hideki; Sharon Ronit; Hattori Nobutaka; Langston J William; Mizuno Yoshikuni; Hyman Bradley T; Selkoe Dennis J; Kosik Kenneth S
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology 2002;160(5):1655-67.
2002: McLean Pamela J; Hyman Bradley T
An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.
Neuroscience letters 2002;323(3):219-23.
2002: Gómez-Tortosa Estrella; Gonzalo Isabel; Newell Kathy; García Yébenes Justo; Vonsattel Paul; Hyman Bradley T
Patterns of protein nitration in dementia with Lewy bodies and striatonigral degeneration.
Acta neuropathologica 2002;103(5):495-500.
2002: Killiany R J; Hyman B T; Gomez-Isla T; Moss M B; Kikinis R; Jolesz F; Tanzi R; Jones K; Albert M S
MRI measures of entorhinal cortex vs hippocampus in preclinical AD.
Neurology 2002;58(8):1188-96.
2002: Qiu Zhihua; Strickland Dudley K; Hyman Bradley T; Rebeck G William
alpha 2-Macroglobulin exposure reduces calcium responses to N-methyl-D-aspartate via low density lipoprotein receptor-related protein in cultured hippocampal neurons.
The Journal of biological chemistry 2002;277(17):14458-66.
2002: Mathis Chester A; Bacskai Brian J; Kajdasz Stephen T; McLellan Megan E; Frosch Matthew P; Hyman Bradley T; Holt Daniel P; Wang Yanming; Huang Guo-Feng; Debnath Manik L; Klunk William E
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Bioorganic & medicinal chemistry letters 2002;12(3):295-8.
2002: Augustinack Jean C; Schneider Anja; Mandelkow Eva-Maria; Hyman Bradley T
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.
Acta neuropathologica 2002;103(1):26-35.
2002: Xia MengQi; Hyman Bradley T
GROalpha/KC, a chemokine receptor CXCR2 ligand, can be a potent trigger for neuronal ERK1/2 and PI-3 kinase pathways and for tau hyperphosphorylation-a role in Alzheimer's disease?
Journal of neuroimmunology 2002;122(1-2):55-64.
2002: Ingelsson Martin; Hyman Bradley T
Disordered proteins in dementia.
Annals of medicine 2002;34(4):259-71.
2002: Zaidi N F; Berezovska O; Choi E K; Miller J S; Chan H; Lilliehook C; Hyman B T; Buxbaum J D; Wasco W
Biochemical and immunocytochemical characterization of calsenilin in mouse brain.
Neuroscience 2002;114(1):247-63.
2002: Spittaels K; Van den Haute C; Van Dorpe J; Terwel D; Vandezande K; Lasrado R; Bruynseels K; Irizarry M; Verhoye M; Van Lint J; Vandenheede J R; Ashton D; Mercken M; Loos R; Hyman B; Van der Linden A; Geerts H; Van Leuven F
Neonatal neuronal overexpression of glycogen synthase kinase-3 beta reduces brain size in transgenic mice.
Neuroscience 2002;113(4):797-808.
2001: Kinoshita A; Whelan C M; Smith C J; Mikhailenko I; Rebeck G W; Strickland D K; Hyman B T
Demonstration by fluorescence resonance energy transfer of two sites of interaction between the low-density lipoprotein receptor-related protein and the amyloid precursor protein: role of the intracellular adapter protein Fe65.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(21):8354-61.
2001: Sharma N; McLean P J; Kawamata H; Irizarry M C; Hyman B T
Alpha-synuclein has an altered conformation and shows a tight intermolecular interaction with ubiquitin in Lewy bodies.
Acta neuropathologica 2001;102(4):329-34.
2001: Irizarry M C; Hyman B T
Alzheimer disease therapeutics.
Journal of neuropathology and experimental neurology 2001;60(10):923-8.
2001: Puglielli L; Konopka G; Pack-Chung E; Ingano L A; Berezovska O; Hyman B T; Chang T Y; Tanzi R E; Kovacs D M
Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide.
Nature cell biology 2001;3(10):905-12.
2001: Le R; Cruz L; Urbanc B; Knowles R B; Hsiao-Ashe K; Duff K; Irizarry M C; Stanley H E; Hyman B T
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Journal of neuropathology and experimental neurology 2001;60(8):753-8.
2001: Berezovska O; Jack C; Deng A; Gastineau N; Rebeck G W; Hyman B T
Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage.
The Journal of biological chemistry 2001;276(32):30018-23.
2001: Christie R; Kimchi E; Kajdasz S; Bacskai B; Hyman B T
Multiphoton microscopy and amyloid angiopathy.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2001;8 Suppl 1():48-50.
2001: Sharma N; Hewett J; Ozelius L J; Ramesh V; McLean P J; Breakefield X O; Hyman B T
A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study.
The American journal of pathology 2001;159(1):339-44.
2001: Hyman B T; Smith C; Buldyrev I; Whelan C; Brown H; Tang M X; Mayeux R
Autoantibodies to amyloid-beta and Alzheimer's disease.
Annals of neurology 2001;49(6):808-10.
2001: Qiu Z; Strickland D K; Hyman B T; Rebeck G W
Elevation of LDL receptor-related protein levels via ligand interactions in Alzheimer disease and in vitro.
Journal of neuropathology and experimental neurology 2001;60(5):430-40.
2001: Chung H; Brazil M I; Irizarry M C; Hyman B T; Maxfield F R
Uptake of fibrillar beta-amyloid by microglia isolated from MSR-A (type I and type II) knockout mice.
Neuroreport 2001;12(6):1151-4.
2001: Kawamata H; McLean P J; Sharma N; Hyman B T
Interaction of alpha-synuclein and synphilin-1: effect of Parkinson's disease-associated mutations.
Journal of neurochemistry 2001;77(3):929-34.
2001: Cho H S; Hyman B T; Greenberg S M; Rebeck G W
Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation.
Journal of neuropathology and experimental neurology 2001;60(4):342-9.
2001: Hyman B T
Molecular and anatomical studies in Alzheimer's disease.
Neurología (Barcelona, Spain) 2001;16(3):100-4.
2001: Stern Y; Jacobs D; Goldman J; Gomez-Tortosa E; Hyman B T; Liu Y; Troncoso J; Marder K; Tang M X; Brandt J; Albert M
An investigation of clinical correlates of Lewy bodies in autopsy-proven Alzheimer disease.
Archives of neurology 2001;58(3):460-5.
2001: Rebeck G W; Moir R D; Mui S; Strickland D K; Tanzi R E; Hyman B T
Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP.
Brain research. Molecular brain research 2001;87(2):238-45.
2001: Jack C; Berezovska O; Wolfe M S; Hyman B T
Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons.
Brain research. Molecular brain research 2001;87(2):166-74.
2001: Kimchi E Y; Kajdasz S; Bacskai B J; Hyman B T
Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy.
Journal of neuropathology and experimental neurology 2001;60(3):274-9.
2001: Christie R; Yamada M; Moskowitz M; Hyman B
Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy.
The American journal of pathology 2001;158(3):1065-71.
2001: Bacskai B J; Kajdasz S T; Christie R H; Carter C; Games D; Seubert P; Schenk D; Hyman B T
Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy.
Nature medicine 2001;7(3):369-72.
2001: Cha J H; Farrell L A; Ahmed S F; Frey A; Hsiao-Ashe K K; Young A B; Penney J B; Locascio J J; Hyman B T; Irizarry M C
Glutamate receptor dysregulation in the hippocampus of transgenic mice carrying mutated human amyloid precursor protein.
Neurobiology of disease 2001;8(1):90-102.
2001: Christie R H; Bacskai B J; Zipfel W R; Williams R M; Kajdasz S T; Webb W W; Hyman B T
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(3):858-64.
2001: Bertram L; Guénette S; Jones J; Keeney D; Mullin K; Crystal A; Basu S; Yhu S; Deng A; Rebeck G W; Hyman B T; Go R; McInnis M; Blacker D; Tanzi R
No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease.
Annals of neurology 2001;49(1):114-6.
2001: Gómez-Tortosa E; Sanders J L; Newell K; Hyman B T
Cortical neurons expressing calcium binding proteins are spared in dementia with Lewy bodies.
Acta neuropathologica 2001;101(1):36-42.
2001: Irizarry M C; Locascio J J; Hyman B T
beta-site APP cleaving enzyme mRNA expression in APP transgenic mice: anatomical overlap with transgene expression and static levels with aging.
The American journal of pathology 2001;158(1):173-7.
2001: McLean P J; Kawamata H; Hyman B T
Alpha-synuclein-enhanced green fluorescent protein fusion proteins form proteasome sensitive inclusions in primary neurons.
Neuroscience 2001;104(3):901-12.
2000: Guénette S Y; Bertram L; Crystal A; Bakondi B; Hyman B T; Rebeck G W; Tanzi R E; Blacker D
Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients.
Neuroscience letters 2000;296(1):17-20.
2000: Chin J Y; Knowles R B; Schneider A; Drewes G; Mandelkow E M; Hyman B T
Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study.
Journal of neuropathology and experimental neurology 2000;59(11):966-71.
2000: Finckh U; von der Kammer H; Velden J; Michel T; Andresen B; Deng A; Zhang J; Müller-Thomsen T; Zuchowski K; Menzer G; Mann U; Papassotiropoulos A; Heun R; Zurdel J; Holst F; Benussi L; Stoppe G; Reiss J; Miserez A R; Staehelin H B; Rebeck G W; Hyman B T; Binetti G; Hock C; Growdon J H; Nitsch R M
Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease.
Archives of neurology 2000;57(11):1579-83.
2000: Irizarry M C; Cheung B S; Rebeck G W; Paul S M; Bales K R; Hyman B T
Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.
Acta neuropathologica 2000;100(5):451-8.
2000: Bacskai B J; Xia M Q; Strickland D K; Rebeck G W; Hyman B T
The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(21):11551-6.
2000: Matsushita K; Wu Y; Qiu J; Lang-Lazdunski L; Hirt L; Waeber C; Hyman B T; Yuan J; Moskowitz M A
Fas receptor and neuronal cell death after spinal cord ischemia.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(18):6879-87.
2000: Xia M Q; Bacskai B J; Knowles R B; Qin S X; Hyman B T
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease.
Journal of neuroimmunology 2000;108(1-2):227-35.
2000: Berezovska O; Jack C; McLean P; Aster J C; Hicks C; Xia W; Wolfe M S; Kimberly W T; Weinmaster G; Selkoe D J; Hyman B T
Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.
Journal of neurochemistry 2000;75(2):583-93.
2000: Vidal R; Calero M; Piccardo P; Farlow M R; Unverzagt F W; Méndez E; Jiménez-Huete A; Beavis R; Gallo G; Gomez-Tortosa E; Ghiso J; Hyman B T; Frangione B; Ghetti B
Senile dementia associated with amyloid beta protein angiopathy and tau perivascular pathology but not neuritic plaques in patients homozygous for the APOE-epsilon4 allele.
Acta neuropathologica 2000;100(1):1-12.
2000: Takeuchi A; Irizarry M C; Duff K; Saido T C; Hsiao Ashe K; Hasegawa M; Mann D M; Hyman B T; Iwatsubo T
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.
The American journal of pathology 2000;157(1):331-9.
2000: Cataldo A M; Peterhoff C M; Troncoso J C; Gomez-Isla T; Hyman B T; Nixon R A
Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.
The American journal of pathology 2000;157(1):277-86.
2000: Holtzman D M; Fagan A M; Mackey B; Tenkova T; Sartorius L; Paul S M; Bales K; Ashe K H; Irizarry M C; Hyman B T
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.
Annals of neurology 2000;47(6):739-47.
2000: Hyman B T; Strickland D; Rebeck G W
Role of the low-density lipoprotein receptor-related protein in beta-amyloid metabolism and Alzheimer disease.
Archives of neurology 2000;57(5):646-50.
2000: Buldyrev S V; Cruz L; Gomez-Isla T; Gomez-Tortosa E; Havlin S; Le R; Stanley H E; Urbanc B; Hyman B T
Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5039-43.
2000: Gómez-Tortosa E; Newell K; Irizarry M C; Sanders J L; Hyman B T
alpha-Synuclein immunoreactivity in dementia with Lewy bodies: morphological staging and comparison with ubiquitin immunostaining.
Acta neuropathologica 2000;99(4):352-7.
2000: Killiany R J; Gomez-Isla T; Moss M; Kikinis R; Sandor T; Jolesz F; Tanzi R; Jones K; Hyman B T; Albert M S
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease.
Annals of neurology 2000;47(4):430-9.
2000: McLean P J; Kawamata H; Ribich S; Hyman B T
Membrane association and protein conformation of alpha-synuclein in intact neurons. Effect of Parkinson's disease-linked mutations.
The Journal of biological chemistry 2000;275(12):8812-6.
2000: Ulery P G; Beers J; Mikhailenko I; Tanzi R E; Rebeck G W; Hyman B T; Strickland D K
Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease.
The Journal of biological chemistry 2000;275(10):7410-5.
2000: Gómez-Tortosa E; Irizarry M C; Gómez-Isla T; Hyman B T
Clinical and neuropathological correlates of dementia with Lewy bodies.
Annals of the New York Academy of Sciences 2000;920():9-15.
2000: Berezovska O; Jack C; McLean P; Aster J C; Hicks C; Xia W; Wolfe M S; Weinmaster G; Selkoe D J; Hyman B T
Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.
Annals of the New York Academy of Sciences 2000;920():223-6.
2000: Irizarry M C; Rebeck G W; Cheung B; Bales K; Paul S M; Holzman D; Hyman B T
Modulation of A beta deposition in APP transgenic mice by an apolipoprotein E null background.
Annals of the New York Academy of Sciences 2000;920():171-8.
2000: McLean P J; Ribich S; Hyman B T
Subcellular localization of alpha-synuclein in primary neuronal cultures: effect of missense mutations.
Journal of neural transmission. Supplementum 2000;(58):53-63.
1999: Newell K L; Boyer P; Gomez-Tortosa E; Hobbs W; Hedley-Whyte E T; Vonsattel J P; Hyman B T
Alpha-synuclein immunoreactivity is present in axonal swellings in neuroaxonal dystrophy and acute traumatic brain injury.
Journal of neuropathology and experimental neurology 1999;58(12):1263-8.
1999: Gómez-Isla T; Growdon W B; McNamara M; Newell K; Gómez-Tortosa E; Hedley-Whyte E T; Hyman B T
Clinicopathologic correlates in temporal cortex in dementia with Lewy bodies.
Neurology 1999;53(9):2003-9.
1999: Newell K L; Hyman B T; Growdon J H; Hedley-Whyte E T
Application of the National Institute on Aging (NIA)-Reagan Institute criteria for the neuropathological diagnosis of Alzheimer disease.
Journal of neuropathology and experimental neurology 1999;58(11):1147-55.
1999: Gómez-Tortosa E; Newell K; Irizarry M C; Albert M; Growdon J H; Hyman B T
Clinical and quantitative pathologic correlates of dementia with Lewy bodies.
Neurology 1999;53(6):1284-91.
1999: Knowles R B; Chin J; Ruff C T; Hyman B T
Demonstration by fluorescence resonance energy transfer of a close association between activated MAP kinase and neurofibrillary tangles: implications for MAP kinase activation in Alzheimer disease.
Journal of neuropathology and experimental neurology 1999;58(10):1090-8.
1999: Mikhailenko I; Considine W; Argraves K M; Loukinov D; Hyman B T; Strickland D K
Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms.
Journal of cell science 1999;112 ( Pt 19)():3269-81.
1999: Qiu Z; Strickland D K; Hyman B T; Rebeck G W
Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.
Journal of neurochemistry 1999;73(4):1393-8.
1999: Growdon W B; Cheung B S; Hyman B T; Rebeck G W
Lack of allelic imbalance in APOE epsilon3/4 brain mRNA expression in Alzheimer's disease.
Neuroscience letters 1999;272(2):83-6.
1999: Rebeck G W; Cheung B S; Growdon W B; Deng A; Akuthota P; Locascio J; Greenberg S M; Hyman B T
Lack of independent associations of apolipoprotein E promoter and intron 1 polymorphisms with Alzheimer's disease.
Neuroscience letters 1999;272(3):155-8.
1999: Gómez-Isla T; Growdon W B; McNamara M J; Nochlin D; Bird T D; Arango J C; Lopera F; Kosik K S; Lantos P L; Cairns N J; Hyman B T
The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: evidence for other phenotype-modifying factors.
Brain : a journal of neurology 1999;122 ( Pt 9)():1709-19.
1999: Urbanc B; Cruz L; Buldyrev S V; Havlin S; Hyman B T; Stanley H E
Dynamic feedback in an aggregation-disaggregation model.
Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics 1999;60(2 Pt B):2120-6.
1999: Berezovska O; Frosch M; McLean P; Knowles R; Koo E; Kang D; Shen J; Lu F M; Lux S E; Tonegawa S; Hyman B T
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
Brain research. Molecular brain research 1999;69(2):273-80.
1999: Knowles R B; Wyart C; Buldyrev S V; Cruz L; Urbanc B; Hasselmo M E; Stanley H E; Hyman B T
Plaque-induced neurite abnormalities: implications for disruption of neural networks in Alzheimer's disease.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(9):5274-9.
1999: Clatworthy A E; Stockinger W; Christie R H; Schneider W J; Nimpf J; Hyman B T; Rebeck G W
Expression and alternate splicing of apolipoprotein E receptor 2 in brain.
Neuroscience 1999;90(3):903-11.
1999: Chapman P F; White G L; Jones M W; Cooper-Blacketer D; Marshall V J; Irizarry M; Younkin L; Good M A; Bliss T V; Hyman B T; Younkin S G; Hsiao K K
Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice.
Nature neuroscience 1999;2(3):271-6.
1999: Urbanc B; Cruz L; Buldyrev S V; Havlin S; Irizarry M C; Stanley H E; Hyman B T
Dynamics of plaque formation in Alzheimer's disease.
Biophysical journal 1999;76(3):1330-4.
1999: Xia M Q; Hyman B T
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease.
Journal of neurovirology 1999;5(1):32-41.
1999: Liao A; Gómez-Isla T; Clatworthy A; Hyman B T
Lack of association of presenilin-1 intron-8 polymorphism with neuropathological features of Alzheimer's disease.
Brain research 1999;816(2):295-8.
1999: Berezovska O; McLean P; Knowles R; Frosh M; Lu F M; Lux S E; Hyman B T
Notch1 inhibits neurite outgrowth in postmitotic primary neurons.
Neuroscience 1999;93(2):433-9.
1999: Irizarry M C; Ghaemi S N; Lee-Cherry E R; Gomez-Isla T; Binetti G; Hyman B T; Growdon J H
Risperidone treatment of behavioral disturbances in outpatients with dementia.
The Journal of neuropsychiatry and clinical neurosciences 1999;11(3):336-42.
1998: Knowles R B; Gomez-Isla T; Hyman B T
Abeta associated neuropil changes: correlation with neuronal loss and dementia.
Journal of neuropathology and experimental neurology 1998;57(12):1122-30.
1998: Liao A; Nitsch R M; Greenberg S M; Finckh U; Blacker D; Albert M; Rebeck G W; Gomez-Isla T; Clatworthy A; Binetti G; Hock C; Mueller-Thomsen T; Mann U; Zuchowski K; Beisiegel U; Staehelin H; Growdon J H; Tanzi R E; Hyman B T
Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.
Human molecular genetics 1998;7(12):1953-6.
1998: Gómez-Tortosa E; Ingraham A O; Irizarry M C; Hyman B T
Dementia with Lewy bodies.
Journal of the American Geriatrics Society 1998;46(11):1449-58.
1998: Yang L; Matthews R T; Schulz J B; Klockgether T; Liao A W; Martinou J C; Penney J B; Hyman B T; Beal M F
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(20):8145-52.
1998: Hyman B T
New neuropathological criteria for Alzheimer disease.
Archives of neurology 1998;55(9):1174-6.
1998: McNamara M J; Ruff C T; Wasco W; Tanzi R E; Thinakaran G; Hyman B T
Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains.
Brain research 1998;804(1):45-51.
1998: Berezovska O; Xia M Q; Hyman B T
Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease.
Journal of neuropathology and experimental neurology 1998;57(8):738-45.
1998: Blacker D; Wilcox M A; Laird N M; Rodes L; Horvath S M; Go R C; Perry R; Watson B; Bassett S S; McInnis M G; Albert M S; Hyman B T; Tanzi R E
Alpha-2 macroglobulin is genetically associated with Alzheimer disease.
Nature genetics 1998;19(4):357-60.
1998: Page K J; Hollister R D; Hyman B T
Dissociation of apolipoprotein and apolipoprotein receptor response to lesion in the rat brain: an in situ hybridization study.
Neuroscience 1998;85(4):1161-71.
1998: McNamara M J; Gomez-Isla T; Hyman B T
Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease.
Archives of neurology 1998;55(7):1001-4.
1998: Xia M Q; Qin S X; Wu L J; Mackay C R; Hyman B T
Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains.
The American journal of pathology 1998;153(1):31-7.
1998: Xia M Q; Berezovska O; Kim T W; Xia W M; Liao A; Tanzi R E; Selkoe D; Hyman B T
Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease.
Journal of the neurological sciences 1998;158(1):15-23.
1998: Peters A; Morrison J H; Rosene D L; Hyman B T
Feature article: are neurons lost from the primate cerebral cortex during normal aging?
Cerebral cortex (New York, N.Y. : 1991) 1998;8(4):295-300.
1998: Hollenbach E; Ackermann S; Hyman B T; Rebeck G W
Confirmation of an association between a polymorphism in exon 3 of the low-density lipoprotein receptor-related protein gene and Alzheimer's disease.
Neurology 1998;50(6):1905-7.
1998: Hyman B T
Neuronal loss in Alzheimer's disease.
Aging (Milan, Italy) 1998;10(2):156.
1998: Alonzo N C; Hyman B T; Rebeck G W; Greenberg S M
Progression of cerebral amyloid angiopathy: accumulation of amyloid-beta40 in affected vessels.
Journal of neuropathology and experimental neurology 1998;57(4):353-9.
1998: Irizarry M C; Growdon W; Gomez-Isla T; Newell K; George J M; Clayton D F; Hyman B T
Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity.
Journal of neuropathology and experimental neurology 1998;57(4):334-7.
1998: Hyman B T; Gomez-Isla T; Irizarry M C
Stereology: a practical primer for neuropathology.
Journal of neuropathology and experimental neurology 1998;57(4):305-10.
1998: Greenberg S M; Vonsattel J P; Segal A Z; Chiu R I; Clatworthy A E; Liao A; Hyman B T; Rebeck G W
Association of apolipoprotein E epsilon2 and vasculopathy in cerebral amyloid angiopathy.
Neurology 1998;50(4):961-5.
1998: Ghorpade A; Xia M Q; Hyman B T; Persidsky Y; Nukuna A; Bock P; Che M; Limoges J; Gendelman H E; Mackay C R
Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia.
Journal of virology 1998;72(4):3351-61.
1998: Silver M; Newell K; Hyman B; Growdon J; Hedley-Whyte E T; Perls T
Unraveling the mystery of cognitive changes in old age: correlation of neuropsychological evaluation with neuropathological findings in the extreme old.
International psychogeriatrics / IPA 1998;10(1):25-41.
1998: Hyman B T
Biomarkers in Alzheimer's disease.
Neurobiology of aging 1998;19(2):159-60.
1998: Endres M; Namura S; Shimizu-Sasamata M; Waeber C; Zhang L; Gómez-Isla T; Hyman B T; Moskowitz M A
Attenuation of delayed neuronal death after mild focal ischemia in mice by inhibition of the caspase family.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 1998;18(3):238-47.
1998: Mayeux R; Saunders A M; Shea S; Mirra S; Evans D; Roses A D; Hyman B T; Crain B; Tang M X; Phelps C H
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.
The New England journal of medicine 1998;338(8):506-11.
1998: Rebeck G W; Alonzo N C; Berezovska O; Harr S D; Knowles R B; Growdon J H; Hyman B T; Mendez A J
Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes.
Experimental neurology 1998;149(1):175-82.
1998: Frautschy S A; Yang F; Irrizarry M; Hyman B; Saido T C; Hsiao K; Cole G M
Microglial response to amyloid plaques in APPsw transgenic mice.
The American journal of pathology 1998;152(1):307-17.
1997: Ferrucci L; Guralnik J M; Pahor M; Harris T; Corti M C; Hyman B T; Wallace R B; Havlik R J
Apolipoprotein E epsilon 2 allele and risk of stroke in the older population.
Stroke; a journal of cerebral circulation 1997;28(12):2410-6.
1997: Farrer L A; Cupples L A; Haines J L; Hyman B; Kukull W A; Mayeux R; Myers R H; Pericak-Vance M A; Risch N; van Duijn C M
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.
JAMA : the journal of the American Medical Association 1997;278(16):1349-56.
1997: Clatworthy A E; Gomez-Isla T; Rebeck G W; Wallace R B; Hyman B T
Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease.
Archives of neurology 1997;54(10):1289-92.
1997: Hyman B T; Trojanowski J Q
Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease.
Journal of neuropathology and experimental neurology 1997;56(10):1095-7.
1997: Vorwerk C K; Hyman B T; Miller J W; Husain D; Zurakowski D; Huang P L; Fishman M C; Dreyer E B
The role of neuronal and endothelial nitric oxide synthase in retinal excitotoxicity.
Investigative ophthalmology & visual science 1997;38(10):2038-44.
1997: Irizarry M C; McNamara M; Fedorchak K; Hsiao K; Hyman B T
APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1.
Journal of neuropathology and experimental neurology 1997;56(9):965-73.
1997: Irizarry M C; Soriano F; McNamara M; Page K J; Schenk D; Games D; Hyman B T
Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):7053-9.
1997: Ayata C; Ayata G; Hara H; Matthews R T; Beal M F; Ferrante R J; Endres M; Kim A; Christie R H; Waeber C; Huang P L; Hyman B T; Moskowitz M A
Mechanisms of reduced striatal NMDA excitotoxicity in type I nitric oxide synthase knock-out mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(18):6908-17.
1997: Hollister R D; Page K J; Hyman B T
Distribution of the messenger RNA for the extracellularly regulated kinases 1, 2 and 3 in rat brain: effects of excitotoxic hippocampal lesions.
Neuroscience 1997;79(4):1111-9.
1997: Hyman B T
The neuropathological diagnosis of Alzheimer's disease: clinical-pathological studies.
Neurobiology of aging 1997;18(4 Suppl):S27-32.
1997: Hyman B T; Gomez-Isla T
The natural history of Alzheimer neurofibrillary tangles and amyloid deposits.
Neurobiology of aging 1997;18(4):386-7; discussion 389-92.
1997: Cruz L; Urbanc B; Buldyrev S V; Christie R; Gómez-Isla T; Havlin S; McNamara M; Stanley H E; Hyman B T
Aggregation and disaggregation of senile plaques in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(14):7612-6.
1997: Gómez-Isla T; Wasco W; Pettingell W P; Gurubhagavatula S; Schmidt S D; Jondro P D; McNamara M; Rodes L A; DiBlasi T; Growdon W B; Seubert P; Schenk D; Growdon J H; Hyman B T; Tanzi R E
A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.
Annals of neurology 1997;41(6):809-13.
1997: Greenberg S M; Hyman B T
Cerebral amyloid angiopathy and apolipoprotein E: bad news for the good allele?
Annals of neurology 1997;41(6):701-2.
1997: Corkin S; Amaral D G; González R G; Johnson K A; Hyman B T
H. M.'s medial temporal lobe lesion: findings from magnetic resonance imaging.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1997;17(10):3964-79.
1997: Xia M; Qin S; McNamara M; Mackay C; Hyman B T
Interleukin-8 receptor B immunoreactivity in brain and neuritic plaques of Alzheimer's disease.
The American journal of pathology 1997;150(4):1267-74.
1997: Fallon J; Matthews R T; Hyman B T; Beal M F
MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.
Experimental neurology 1997;144(1):193-8.
1997: Hollister R D; Xia M; McNamara M J; Hyman B T
Neuronal expression of class II major histocompatibility complex (HLA-DR) in 2 cases of Pick disease.
Archives of neurology 1997;54(3):243-8.
1997: García-Añoveros J; Derfler B; Neville-Golden J; Hyman B T; Corey D P
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(4):1459-64.
1997: Gómez-Isla T; Hollister R; West H; Mui S; Growdon J H; Petersen R C; Parisi J E; Hyman B T
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.
Annals of neurology 1997;41(1):17-24.
1997: Berezovska O; Xia M Q; Page K; Wasco W; Tanzi R E; Hyman B T
Developmental regulation of presenilin mRNA expression parallels notch expression.
Journal of neuropathology and experimental neurology 1997;56(1):40-4.
1997: Matthews R T; Beal M F; Fallon J; Fedorchak K; Huang P L; Fishman M C; Hyman B T
MPP+ induced substantia nigra degeneration is attenuated in nNOS knockout mice.
Neurobiology of disease 1997;4(2):114-21.
1996: Hyman B T; Gomez-Isla T; Rebeck G W; Briggs M; Chung H; West H L; Greenberg S; Mui S; Nichols S; Wallace R; Growdon J H
Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease.
Annals of the New York Academy of Sciences 1996;802():1-5.
1996: Biere A L; Ostaszewski B; Stimson E R; Hyman B T; Maggio J E; Selkoe D J
Amyloid beta-peptide is transported on lipoproteins and albumin in human plasma.
The Journal of biological chemistry 1996;271(51):32916-22.
1996: Hyman B T
Apolipoprotein E genotype: utility in clinical practice in Alzheimer's disease.
Journal of the American Geriatrics Society 1996;44(12):1469-71.
1996: Hyman B T; Gomez-Isla T
Neuropathological markers of impaired cognition in the entorhinal cortex.
Neurobiology of aging 1996;17(6):940-1; discussion 945-7.
1996: Page K; Hollister R; Tanzi R E; Hyman B T
In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(24):14020-4.
1996: Hyman B T
Alzheimer's disease or Alzheimer's diseases? Clues from molecular epidemiology.
Annals of neurology 1996;40(2):135-6.
1996: Irizarry M C; Kim T W; McNamara M; Tanzi R E; George J M; Clayton D F; Hyman B T
Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system.
Journal of neuropathology and experimental neurology 1996;55(8):889-95.
1996: Growdon J H; Locascio J J; Corkin S; Gomez-Isla T; Hyman B T
Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease.
Neurology 1996;47(2):444-8.
1996: Greenberg S M; Briggs M E; Hyman B T; Kokoris G J; Takis C; Kanter D S; Kase C S; Pessin M S
Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy.
Stroke; a journal of cerebral circulation 1996;27(8):1333-7.
1996: Hollister R D; Kisiel W; Hyman B T
Immunohistochemical localization of tissue factor pathway inhibitor-1 (TFPI-1), a Kunitz proteinase inhibitor, in Alzheimer's disease.
Brain research 1996;728(1):13-9.
1996: Mui S; Briggs M; Chung H; Wallace R B; Gomez-Isla T; Rebeck G W; Hyman B T
A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele.
Neurology 1996;47(1):196-201.
1996: Gómez-Isla T; Price J L; McKeel D W; Morris J C; Growdon J H; Hyman B T
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1996;16(14):4491-500.
1996: Hyman B T; Gomez-Isla T; Briggs M; Chung H; Nichols S; Kohout F; Wallace R
Apolipoprotein E and cognitive change in an elderly population.
Annals of neurology 1996;40(1):55-66.
1996: Vorwerk C K; Lipton S A; Zurakowski D; Hyman B T; Sabel B A; Dreyer E B
Chronic low-dose glutamate is toxic to retinal ganglion cells. Toxicity blocked by memantine.
Investigative ophthalmology & visual science 1996;37(8):1618-24.
1996: Chung H; Roberts C T; Greenberg S; Rebeck G W; Christie R; Wallace R; Jacob H J; Hyman B T
Lack of association of trinucleotide repeat polymorphisms in very-low-density lipoprotein receptor gene with Alzheimer's disease.
Annals of neurology 1996;39(6):800-3.
1996: Harr S D; Uint L; Hollister R; Hyman B T; Mendez A J
Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease.
Journal of neurochemistry 1996;66(6):2429-35.
1996: Harr S D; Hollister R D; Hyman B T
Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles.
Neurobiology of aging 1996;17(3):343-8.
1996: Christie R H; Chung H; Rebeck G W; Strickland D; Hyman B T
Expression of the very low-density lipoprotein receptor (VLDL-r), an apolipoprotein-E receptor, in the central nervous system and in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1996;55(4):491-8.
1996: Hyman B T; Hedley-Whyte E T; Rebeck G W; Vonsattel J P; West H L; Growdon J H
Apolipoprotein E epsilon4/4 in a neuropathologically normal very elderly individual.
Archives of neurology 1996;53(3):215.
1996: Lippa C F; Saunders A M; Smith T W; Swearer J M; Drachman D A; Ghetti B; Nee L; Pulaski-Salo D; Dickson D; Robitaille Y; Bergeron C; Crain B; Benson M D; Farlow M; Hyman B T; George-Hyslop S P; Roses A D; Pollen D A
Familial and sporadic Alzheimer's disease: neuropathology cannot exclude a final common pathway.
Neurology 1996;46(2):406-12.
1996: Christie R H; Freeman M; Hyman B T
Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.
The American journal of pathology 1996;148(2):399-403.
1996: Kovacs D M; Fausett H J; Page K J; Kim T W; Moir R D; Merriam D E; Hollister R D; Hallmark O G; Mancini R; Felsenstein K M; Hyman B T; Tanzi R E; Wasco W
Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.
Nature medicine 1996;2(2):224-9.
1996: Hyman B T; Gomez-Isla T; West H; Briggs M; Chung H; Growdon J H; Rebeck G W
Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology.
Annals of the New York Academy of Sciences 1996;777():158-65.
1996: Gomez-Isla T; West H L; Rebeck G W; Harr S D; Growdon J H; Locascio J J; Perls T T; Lipsitz L A; Hyman B T
Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease.
Annals of neurology 1996;39(1):62-70.
1995: Gearing M; Schneider J A; Robbins R S; Hollister R D; Mori H; Games D; Hyman B T; Mirra S S
Regional variation in the distribution of apolipoprotein E and A beta in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1995;54(6):833-41.
1995: Hyman B T; Tanzi R
Molecular epidemiology of Alzheimer's disease.
The New England journal of medicine 1995;333(19):1283-4.
1995: Gearing M; Schneider J A; Rebeck G W; Hyman B T; Mirra S S
Alzheimer's disease with and without coexisting Parkinson's disease changes: apolipoprotein E genotype and neuropathologic correlates.
Neurology 1995;45(11):1985-90.
1995: Poduri A; Beason-Held L L; Moss M B; Rosene D L; Hyman B T
CA3 neuronal degeneration follows chronic entorhinal cortex lesions.
Neuroscience letters 1995;197(1):1-4.
1995: Mui S; Rebeck G W; McKenna-Yasek D; Hyman B T; Brown R H
Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis.
Annals of neurology 1995;38(3):460-3.
1995: Greenberg S M; Rebeck G W; Vonsattel J P; Gomez-Isla T; Hyman B T
Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy.
Annals of neurology 1995;38(2):254-9.
1995: Kounnas M Z; Moir R D; Rebeck G W; Bush A I; Argraves W S; Tanzi R E; Hyman B T; Strickland D K
LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation.
Cell 1995;82(2):331-40.
1995: Simonian N A; Hyman B T
Functional alterations in neural circuits in Alzheimer's disease.
Neurobiology of aging 1995;16(3):305-9.
1995: Hyman B T; West H L; Rebeck G W; Buldyrev S V; Mantegna R N; Ukleja M; Havlin S; Stanley H E
Quantitative analysis of senile plaques in Alzheimer disease: observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down syndrome).
Proceedings of the National Academy of Sciences of the United States of America 1995;92(8):3586-90.
1995: Nitsch R M; Rebeck G W; Deng M; Richardson U I; Tennis M; Schenk D B; Vigo-Pelfrey C; Lieberburg I; Wurtman R J; Hyman B T
Cerebrospinal fluid levels of amyloid beta-protein in Alzheimer's disease: inverse correlation with severity of dementia and effect of apolipoprotein E genotype.
Annals of neurology 1995;37(4):512-8.
1995: Hyman B T; West H L; Rebeck G W; Lai F; Mann D M
Neuropathological changes in Down's syndrome hippocampal formation. Effect of age and apolipoprotein E genotype.
Archives of neurology 1995;52(4):373-8.
1995: Rebeck G W; Hyman B T
Apolipoprotein E--correction.
Neurology 1995;45(3 Pt 1):598.
1995: Golden J A; Nielsen G P; Pober B R; Hyman B T
The neuropathology of Williams syndrome. Report of a 35-year-old man with presenile beta/A4 amyloid plaques and neurofibrillary tangles.
Archives of neurology 1995;52(2):209-12.
1995: Rebeck G W; Harr S D; Strickland D K; Hyman B T
Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.
Annals of neurology 1995;37(2):211-7.
1995: Harr S D; Simonian N A; Hyman B T
Functional alterations in Alzheimer's disease: decreased glucose transporter 3 immunoreactivity in the perforant pathway terminal zone.
Journal of neuropathology and experimental neurology 1995;54(1):38-41.
1994: Brouillet E; Hyman B T; Jenkins B G; Henshaw D R; Schulz J B; Sodhi P; Rosen B R; Beal M F
Systemic or local administration of azide produces striatal lesions by an energy impairment-induced excitotoxic mechanism.
Experimental neurology 1994;129(2):175-82.
1994: Golden J A; Hyman B T
Development of the superior temporal neocortex is anomalous in trisomy 21.
Journal of neuropathology and experimental neurology 1994;53(5):513-20.
1994: Simonian N A; Hyman B T
Functional alterations in Alzheimer's disease: selective loss of mitochondrial-encoded cytochrome oxidase mRNA in the hippocampal formation.
Journal of neuropathology and experimental neurology 1994;53(5):508-12.
1994: Hyman B T; Terry R D
Apolipoprotein E, A beta, and Alzheimer disease.
Journal of neuropathology and experimental neurology 1994;53(5):427-8.
1994: Hyman B T; Strickland D K; Rebeck G W
Alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Relationship to apolipoprotein E and role in Alzheimer disease senile plaques.
Annals of the New York Academy of Sciences 1994;737():88-95.
1994: Gearing M; Rebeck G W; Hyman B T; Tigges J; Mirra S S
Neuropathology and apolipoprotein E profile of aged chimpanzees: implications for Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(20):9382-6.
1994: Simonian N A; Elvhage T; Czernik A J; Greengard P; Hyman B T
Calcium/calmodulin-dependent protein kinase II immunostaining is preserved in Alzheimer's disease hippocampal neurons.
Brain research 1994;657(1-2):294-9.
1994: Rebeck G W; Perls T T; West H L; Sodhi P; Lipsitz L A; Hyman B T
Reduced apolipoprotein epsilon 4 allele frequency in the oldest old Alzheimer's patients and cognitively normal individuals.
Neurology 1994;44(8):1513-6.
1994: West H L; Rebeck G W; Hyman B T
Frequency of the apolipoprotein E epsilon 2 allele is diminished in sporadic Alzheimer disease.
Neuroscience letters 1994;175(1-2):46-8.
1994: Poduri A; Gearing M; Rebeck G W; Mirra S S; Tigges J; Hyman B T
Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.
The American journal of pathology 1994;144(6):1183-7.
1994: Hyman B T; Gomez-Isla T
Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease.
Neurobiology of aging 1994;15(3):353-4; discussion 379-80.
1994: Rebeck G W; Maynard K I; Hyman B T; Moskowitz M A
Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(9):3666-9.
1994: Hyman B T; Elvhage T E; Reiter J
Extracellular signal regulated kinases. Localization of protein and mRNA in the human hippocampal formation in Alzheimer's disease.
The American journal of pathology 1994;144(3):565-72.
1994: Arnold S E; Hyman B T; Van Hoesen G W
Neuropathologic changes of the temporal pole in Alzheimer's disease and Pick's disease.
Archives of neurology 1994;51(2):145-50.
1994: Hyman B T; Penney J B; Blackstone C D; Young A B
Localization of non-N-methyl-D-aspartate glutamate receptors in normal and Alzheimer hippocampal formation.
Annals of neurology 1994;35(1):31-7.
1994: Hyman B T; Reiter J; Moss M; Rosene D; Pandya D
Extracellular signal-regulated kinase (MAP kinase) immunoreactivity in the rhesus monkey brain.
Neuroscience letters 1994;166(1):113-6.
1994: Simonian N A; Rebeck G W; Hyman B T
Functional integrity of neural systems related to memory in Alzheimer's disease.
Progress in brain research 1994;100():245-54.
1994: Hyman B T
Studying the Alzheimer's disease brain: insights, puzzles, and opportunities.
Neurobiology of aging 1994;15 Suppl 2():S79-83.
1993: Hyman B T; Marzloff K; Arriagada P V
The lack of accumulation of senile plaques or amyloid burden in Alzheimer's disease suggests a dynamic balance between amyloid deposition and resolution.
Journal of neuropathology and experimental neurology 1993;52(6):594-600.
1993: Simonian N A; Hyman B T
Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation.
Journal of neuropathology and experimental neurology 1993;52(6):580-5.
1993: Rebeck G W; Reiter J S; Strickland D K; Hyman B T
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions.
Neuron 1993;11(4):575-80.
1993: Beal M F; Brouillet E; Jenkins B G; Ferrante R J; Kowall N W; Miller J M; Storey E; Srivastava R; Rosen B R; Hyman B T
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1993;13(10):4181-92.
1993: Wasco W; Gurubhagavatula S; Paradis M D; Romano D M; Sisodia S S; Hyman B T; Neve R L; Tanzi R E
Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor.
Nature genetics 1993;5(1):95-100.
1993: Beal M F; Brouillet E; Jenkins B; Henshaw R; Rosen B; Hyman B T
Age-dependent striatal excitotoxic lesions produced by the endogenous mitochondrial inhibitor malonate.
Journal of neurochemistry 1993;61(3):1147-50.
1993: Srivastava R; Brouillet E; Beal M F; Storey E; Hyman B T
Blockade of 1-methyl-4-phenylpyridinium ion (MPP+) nigral toxicity in the rat by prior decortication or MK-801 treatment: a stereological estimate of neuronal loss.
Neurobiology of aging 1993;14(4):295-301.
1993: Tanzi R E; Wenniger J J; Hyman B T
Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation.
Brain research. Molecular brain research 1993;18(3):246-52.
1993: Hyman B T; Wenniger J J; Tanzi R E
Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques.
Brain research. Molecular brain research 1993;18(3):253-8.
1993: Rebeck G W; Marzloff K; Hyman B T
The pattern of NADPH-diaphorase staining, a marker of nitric oxide synthase activity, is altered in the perforant pathway terminal zone in Alzheimer's disease.
Neuroscience letters 1993;152(1-2):165-8.
1993: Beal M F; Hyman B T; Koroshetz W
Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?
Trends in neurosciences 1993;16(4):125-31.
1993: Rebeck G W; Hyman B T
Neuroanatomical connections and specific regional vulnerability in Alzheimer's disease.
Neurobiology of aging 1993;14(1):45-7; discussion 55-6.
1993: Brouillet E; Jenkins B G; Hyman B T; Ferrante R J; Kowall N W; Srivastava R; Roy D S; Rosen B R; Beal M F
Age-dependent vulnerability of the striatum to the mitochondrial toxin 3-nitropropionic acid.
Journal of neurochemistry 1993;60(1):356-9.
1992: Hyman B T; Marzloff K; Wenniger J J; Dawson T M; Bredt D S; Snyder S H
Relative sparing of nitric oxide synthase-containing neurons in the hippocampal formation in Alzheimer's disease.
Annals of neurology 1992;32(6):818-20.
1992: Arriagada P V; Marzloff K; Hyman B T
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease.
Neurology 1992;42(9):1681-8.
1992: Tanzi R E; Vaula G; Romano D M; Mortilla M; Huang T L; Tupler R G; Wasco W; Hyman B T; Haines J L; Jenkins B J
Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.
American journal of human genetics 1992;51(2):273-82.
1992: Storey E; Hyman B T; Jenkins B; Brouillet E; Miller J M; Rosen B R; Beal M F
1-Methyl-4-phenylpyridinium produces excitotoxic lesions in rat striatum as a result of impairment of oxidative metabolism.
Journal of neurochemistry 1992;58(5):1975-8.
1992: Arriagada P V; Growdon J H; Hedley-Whyte E T; Hyman B T
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease.
Neurology 1992;42(3 Pt 1):631-9.
1992: Cabalka L M; Hyman B T; Goodlett C R; Ritchie T C; Van Hoesen G W
Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions.
Neurobiology of aging 1992;13(2):283-91.
1992: Hyman B T; Tanzi R E
Amyloid, dementia and Alzheimer's disease.
Current opinion in neurology and neurosurgery 1992;5(1):88-93.
1992: Hyman B T; Tanzi R E; Marzloff K; Barbour R; Schenk D
Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease.
Journal of neuropathology and experimental neurology 1992;51(1):76-83.
1992: Louis D N; Arriagada P V; Hyman B T; Hedley-Whyte E T
Olfactory dysgenesis or hypoplasia: a variant in the arhinencephaly spectrum?
Neurology 1992;42(1):179-82.
1992: Hyman B T
Down syndrome and Alzheimer disease.
Progress in clinical and biological research 1992;379():123-42.
1991: Finn S F; Hyman B T; Storey E; Miller J M; Beal M F
Effects of aging on quinolinic acid lesions in rat striatum.
Brain research 1991;562(2):276-80.
1991: Hyman B T; Flory J E; Arnold S E; Van Hoesen G W; Schelper R L; Ghanbari H; Haigler H
Quantitative assessment of ALZ-50 immunoreactivity in Alzheimer's disease.
Journal of geriatric psychiatry and neurology 1991;4(4):231-5.
1991: Beal M F; Swartz K J; Hyman B T; Storey E; Finn S F; Koroshetz W
Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism.
Journal of neurochemistry 1991;57(3):1068-73.
1991: Arnold S E; Hyman B T; Van Hoesen G W; Damasio A R
Some cytoarchitectural abnormalities of the entorhinal cortex in schizophrenia.
Archives of general psychiatry 1991;48(7):625-32.
1991: Tanzi R E; Hyman B T
Alzheimer's mutation.
Nature 1991;350(6319):564.
1991: Arriagada P V; Louis D N; Hedley-Whyte E T; Hyman B T
Neurofibrillary tangles and olfactory dysgenesis.
Lancet 1991;337(8740):559.
1991: Arnold S E; Hyman B T; Flory J; Damasio A R; Van Hoesen G W
The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease.
Cerebral cortex (New York, N.Y. : 1991) 1991;1(1):103-16.
1991: Van Hoesen G W; Hyman B T; Damasio A R
Entorhinal cortex pathology in Alzheimer's disease.
Hippocampus 1991;1(1):1-8.
1991: Schumacher J M; Short M P; Hyman B T; Breakefield X O; Isacson O
Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids.
Neuroscience 1991;45(3):561-70.
1991: Tanzi R E; Hyman B T
Studies of amyloid beta-protein precursor expression in Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():149-54.
1991: Hyman B T; Arriagada P V; Van Hoesen G W
Pathologic changes in the olfactory system in aging and Alzheimer's disease.
Annals of the New York Academy of Sciences 1991;640():14-9.
1990: Hyman B T; Van Hoesen G W; Damasio A R
Memory-related neural systems in Alzheimer's disease: an anatomic study.
Neurology 1990;40(11):1721-30.
1990: Tourtellotte W G; Van Hoesen G W; Hyman B T; Tikoo R K; Damasio A R
Alz-50 immunoreactivity in the thalamic reticular nucleus in Alzheimer's disease.
Brain research 1990;515(1-2):227-34.
1990: Graff-Radford N R; Damasio A R; Hyman B T; Hart M N; Tranel D; Damasio H; Van Hoesen G W; Rezai K
Progressive aphasia in a patient with Pick's disease: a neuropsychological, radiologic, and anatomic study.
Neurology 1990;40(4):620-6.
1990: Tranel D; Hyman B T
Neuropsychological correlates of bilateral amygdala damage.
Archives of neurology 1990;47(3):349-55.
1990: Van Hoesen G W; Hyman B T
Hippocampal formation: anatomy and the patterns of pathology in Alzheimer's disease.
Progress in brain research 1990;83():445-57.
1990: Kromer Vogt L J; Hyman B T; Van Hoesen G W; Damasio A R
Pathological alterations in the amygdala in Alzheimer's disease.
Neuroscience 1990;37(2):377-85.
1989: Hyman B T; Tranel D
Hemianesthesia and aphasia. An anatomical and behavioral study.
Archives of neurology 1989;46(7):816-9.
1989: Hyman B T; Van Hoesen G W; Beyreuther K; Masters C L
A4 amyloid protein immunoreactivity is present in Alzheimer's disease neurofibrillary tangles.
Neuroscience letters 1989;101(3):352-5.
1989: Hamre K M; Hyman B T; Goodlett C R; West J R; Van Hoesen G W
Alz-50 immunoreactivity in the neonatal rat: changes in development and co-distribution with MAP-2 immunoreactivity.
Neuroscience letters 1989;98(3):264-71.
1989: Hyman B T; Damasio H; Damasio A R; Van Hoesen G W
Alzheimer's disease.
Annual review of public health 1989;10():115-40.
1988: Hyman B T; Kromer L J; Van Hoesen G W
A direct demonstration of the perforant pathway terminal zone in Alzheimer's disease using the monoclonal antibody Alz-50.
Brain research 1988;450(1-2):392-7.
1988: Niles R; Kim K C; Hyman B; Christensen T; Wasano K; Brody J
Characterization of extended primary and secondary cultures of hamster tracheal epithelial cells.
In vitro cellular & developmental biology : journal of the Tissue Culture Association 1988;24(5):457-63.
1988: Hyman B T; Van Hoesen G W; Wolozin B L; Davies P; Kromer L J; Damasio A R
Alz-50 antibody recognizes Alzheimer-related neuronal changes.
Annals of neurology 1988;23(4):371-9.
1987: Hyman B T; Van Hoesen G W
Neuron numbers in Alzheimer's disease: cell-specific pathology.
Neurobiology of aging 1987;8(6):555-6.
1987: Hyman B T; Van Hoesen G W; Damasio A R
Alzheimer's disease: glutamate depletion in the hippocampal perforant pathway zone.
Annals of neurology 1987;22(1):37-40.
1987: Hyman B T; Kromer L J; Van Hoesen G W
Reinnervation of the hippocampal perforant pathway zone in Alzheimer's disease.
Annals of neurology 1987;21(3):259-67.
1986: Hyman B T; Van Hoesen G W; Kromer L J; Damasio A R
Perforant pathway changes and the memory impairment of Alzheimer's disease.
Annals of neurology 1986;20(4):472-81.
1986: Hyman B T; Westrick M A
Multiple myeloma with polyneuropathy and coagulopathy. A case report of the polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin change (POEMS) syndrome.
Archives of internal medicine 1986;146(5):993-4.
1986: Van Hoesen G W; Hyman B T; Damasio A R
Cell-specific pathology in neural systems of the temporal lobe in Alzheimer's disease.
Progress in brain research 1986;70():321-35.
1985: Hyman B T; Eslinger P J; Damasio A R
Effect of naltrexone on senile dementia of the Alzheimer type.
Journal of neurology, neurosurgery, and psychiatry 1985;48(11):1169-71.
1984: Hyman B T; Van Hoesen G W; Damasio A R; Barnes C L
Alzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Science (New York, N.Y.) 1984;225(4667):1168-70.
1983: Yorek M A; Hyman B T; Spector A A
Glycine uptake by cultured human Y79 retinoblastoma cells: effect of changes in phospholipid fatty acid unsaturation.
Journal of neurochemistry 1983;40(1):70-8.
1982: Hyman B T; Stoll L L; Spector A A
Prostaglandin production by 3T3-L1 cells in culture.
Biochimica et biophysica acta 1982;713(2):375-85.
1982: Hyman B T; Spector A A
Choline uptake in cultured human Y79 retinoblastoma cells: effect of polyunsaturated fatty acid compositional modifications.
Journal of neurochemistry 1982;38(3):650-6.
1981: Hyman B T; Haimann M H; Armstrong M L; Spector A A
Fatty acid and lipid composition of the monkey retina in diet-induced hypercholesterolemia.
Atherosclerosis 1981;40(3-4):321-8.
1981: Hyman B T; Stoll L L; Spector A A
Accumulation of (n-9)-eicosatrienoic acid in confluent 3T3-L1 and 3T3 cells.
The Journal of biological chemistry 1981;256(17):8863-6.
1981: Hyman B T; Spector A A
Accumulation of N-3 polyunsaturated fatty acids cultured human Y79 retinoblastoma cells.
Journal of neurochemistry 1981;37(1):60-9.
1977: Walder J A; Hyman B T; Heller M J; Shishido R Y; Klotz I M
Reversible acylation and inhibition of aggregation of platelets by substituted maleic anhydrides.
Molecular pharmacology 1977;13(3):407-14.

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