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Sarah Hymowitz

Research Profile

Concepts & Ideas

Procedures

X Ray Crystallography

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Living Beings

Mouse

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Protein Binding

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Publications

TOP 3
XiaoDong Huang; Sarah G Hymowitz; Michael Kakunda; Jennie R Lill; Bob Y Liu; Jinfeng Liu; James C McGann; Kim Newton; Victoria Pham; Paul Polakis; Anthony Wynshaw-Boris; Christine Yu; Rami N Hannoush; Richard M Harland; Jo-Anne Hongo; Xiaodong Huang
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
Gladys de Leon-Boenig; Christine Everett; Jianwen A Feng; Yvonne Franke; Krista K Bowman; Terry Crawford; Adam R Johnson; Angela Oh; Steven T Staben; Mark Stanley; Melissa A Starovasnik; Heidi J A Wallweber; Jiansheng Wu; Lawren C Wu; Sarah G Hymowitz
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Anwesha Dey; Omar Abdel-Wahab; Corey E Bakalarski; Margit Balazs; Mira S Chaurushiya; Ken Dong; Dorothy M French; Guillermo Garcia-Manero; Sarah G Hymowitz; Paula Katavolos; Donald S Kirkpatrick; Lindsay M LaFave; Ross L Levine; Jennie R Lill; Zhonghua Lin; Jinfeng Liu; Flavius Martin; Zora Modrusan; Kim Newton; Rajkumar Noubade; Victoria C Pham; Lilian Phu; Somasekar Seshagiri; Dhaya Seshasayee; Rowena Suriben; Jiansheng Wu; Vishva M Dixit
Loss of the tumor suppressor BAP1 causes myeloid transformation.

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All Publications

2013: XiaoDong Huang; Sarah G Hymowitz; Michael Kakunda; Jennie R Lill; Bob Y Liu; Jinfeng Liu; James C McGann; Kim Newton; Victoria Pham; Paul Polakis; Anthony Wynshaw-Boris; Christine Yu; Rami N Hannoush; Richard M Harland; Jo-Anne Hongo; Xiaodong Huang
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
Science (New York, N.Y.) 2013;339(6126):1441-5.
2012: Gladys de Leon-Boenig; Christine Everett; Jianwen A Feng; Yvonne Franke; Krista K Bowman; Terry Crawford; Adam R Johnson; Angela Oh; Steven T Staben; Mark Stanley; Melissa A Starovasnik; Heidi J A Wallweber; Jiansheng Wu; Lawren C Wu; Sarah G Hymowitz
The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.
Structure (London, England : 1993) 2012;20(10):1704-14.
2012: Anwesha Dey; Omar Abdel-Wahab; Corey E Bakalarski; Margit Balazs; Mira S Chaurushiya; Ken Dong; Dorothy M French; Guillermo Garcia-Manero; Sarah G Hymowitz; Paula Katavolos; Donald S Kirkpatrick; Lindsay M LaFave; Ross L Levine; Jennie R Lill; Zhonghua Lin; Jinfeng Liu; Flavius Martin; Zora Modrusan; Kim Newton; Rajkumar Noubade; Victoria C Pham; Lilian Phu; Somasekar Seshagiri; Dhaya Seshasayee; Rowena Suriben; Jiansheng Wu; Vishva M Dixit
Loss of the tumor suppressor BAP1 causes myeloid transformation.
Science (New York, N.Y.) 2012;337(6101):1541-6.
2012: Marissa L Matsumoto; Lilian Phu; Christine Yu; Donald S Kirkpatrick; Vishva M Dixit; Ken C Dong; Xinxin Gao; Rami N Hannoush; Sarah G Hymowitz; Robert F Kelley
Engineering and structural characterization of a linear polyubiquitin-specific antibody.
Journal of molecular biology 2012;418(3-4):134-44.
2012: Oscar W Huang; Sarah G Hymowitz; Nobuhiko Kayagaki; Xiaolei Ma; Till Maurer; Qui T Phung; Melissa A Starovasnik; JianPing Yin; David Arnott; Ivan Bosanac; Vishva M Dixit; Jeremy Flinders; Andrea G Cochran
Phosphorylation-dependent activity of the deubiquitinase DUBA.
Nature structural & molecular biology 2012;19(2):171-5.
2011: Erin C Dueber; J Michael Elliott; Kurt Deshayes; Anna V Fedorova; Anthony M Giannetti; Sarah G Hymowitz; Andreas Lingel; Brigitte Maurer; Allyn J Schoeffler; Eugene Varfolomeev; Domagoj Vucic; Heidi J A Wallweber; Ping Wu; Kerry Zobel; Wayne J Fairbrother
Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination.
Science (New York, N.Y.) 2011;334(6054):376-80.
2011: Ken C Dong; David P Arnott; Ivan Bosanac; Deanne M Compaan; Anna V Fedorova; Elizabeth Helgason; Oscar W Huang; Sarah G Hymowitz; Donald S Kirkpatrick; Lilian Phu; Christine Yu; Erin C Dueber
Preparation of distinct ubiquitin chain reagents of high purity and yield.
Structure (London, England : 1993) 2011;19(8):1053-63.
2011: Nicholas S Wilson; Becky Yang; Annie Yang; Stefanie Loeser; Scot A Marsters; David Lawrence; Yun Li; Robert M Pitti; Klara Totpal; Sharon Yee; Sarajane Ross; Jean-Michel Vernes; Yanmei Lu; Cam Adams; Rienk Offringa; Bob Kelley; Sarah G Hymowitz; Dylan Daniel; Gloria Meng; Avi Ashkenazi
An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells.
Cancer cell 2011;19(1):101-13.
2008: Kim Newton; Marissa L Matsumoto; Ingrid E Wertz; Donald Kirkpatrick; Jennie R Lill; Jenille Tan; Debra Dugger; Nathaniel Gordon; Sachdev S Sidhu; Frederic A Fellouse; Laszlo Komuves; Dorothy M French; Ronald E Ferrando; Cynthia Lam; Deanne Compaan; Christine Yu; Ivan Bosanac; Sarah G Hymowitz; Robert F Kelley; Xiaodong Huang
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies.
Cell 2008;134(4):668-78.
2007: Eric Bourhis; Sarah G Hymowitz; Andrea G Cochran
The mitotic regulator Survivin binds as a monomer to its functional interactor Borealin.
The Journal of biological chemistry 2007;282(48):35018-23.
2007: Klaus W Wagner; Elizabeth A Punnoose; Thomas Januario; David A Lawrence; Robert M Pitti; Kate Lancaster; Dori Lee; Melissa von Goetz; Sharon Fong Yee; Klara Totpal; Ling Huw; Viswanatham Katta; Guy Cavet; Sarah G Hymowitz; Lukas C Amler; Avi Ashkenazi
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL.
Nature medicine 2007;13(9):1070-7.
2006: Chingwei V Lee; Sarah G Hymowitz; Heidi J A Wallweber; Nathaniel C Gordon; Karen L Billeci; Siao Ping Tsai; Deanne M Compaan; Jianping Yin; Qian Gong; Robert F Kelley; Laura E DeForge; Flavius Martin; Melissa A Starovasnik; Germaine Fuh
Synthetic anti-BR3 antibodies that mimic BAFF binding and target both human and murine B cells.
Blood 2006;108(9):3103-11.
2006: P M Eimon; E Kratz; Eugene Varfolomeev; Sarah G Hymowitz; H Stern; J Zha; Avi Ashkenazi
Delineation of the cell-extrinsic apoptosis pathway in the zebrafish.
Cell death and differentiation 2006;13(10):1619-30.
2006: Bing Li; Stephen J Russell; Deanne M Compaan; Klara Totpal; Scot A Marsters; Avi Ashkenazi; Andrea G Cochran; Sarah G Hymowitz; Sachdev S Sidhu
Activation of the proapoptotic death receptor DR5 by oligomeric peptide and antibody agonists.
Journal of molecular biology 2006;361(3):522-36.
2006: Deanne M Compaan; Sarah G Hymowitz
The crystal structure of the costimulatory OX40-OX40L complex.
Structure (London, England : 1993) 2006;14(8):1321-30.
2005: Sarah G Hymowitz; Avi Ashkenazi
Toward small-molecule agonists of TNF receptors.
Nature chemical biology 2005;1(7):353-4.
2005: Deanne M Compaan; Lino C Gonzalez; Irene Tom; Kelly M Loyet; Dan Eaton; Sarah G Hymowitz
Attenuating lymphocyte activity: the crystal structure of the BTLA-HVEM complex.
The Journal of biological chemistry 2005;280(47):39553-61.
2005: Frederic A Fellouse; Bing Li; Deanne M Compaan; Andrew A Peden; Sarah G Hymowitz; Sachdev S Sidhu
Molecular recognition by a binary code.
Journal of molecular biology 2005;348(5):1153-62.
2005: Sarah G Hymowitz; Darshana R Patel; Heidi J A Wallweber; Steven Runyon; Minhong Yan; Jianping Yin; Stephanie Shriver; Nathaniel C Gordon; Borlan Pan; Nicholas J Skelton; Robert F Kelley; Melissa A Starovasnik
Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding.
The Journal of biological chemistry 2005;280(8):7218-27.
2005: Robert F Kelley; Klara Totpal; Stephanie H Lindstrom; Mary Mathieu; Karen L Billeci; Laura E DeForge; Roger Pai; Sarah G Hymowitz; Avi Ashkenazi
Receptor-selective mutants of apoptosis-inducing ligand 2/tumor necrosis factor-related apoptosis-inducing ligand reveal a greater contribution of death receptor (DR) 5 than DR4 to apoptosis signaling.
The Journal of biological chemistry 2005;280(3):2205-12.
2004: Heidi J A Wallweber; Deanne M Compaan; Melissa A Starovasnik; Sarah G Hymowitz
The crystal structure of a proliferation-inducing ligand, APRIL.
Journal of molecular biology 2004;343(2):283-90.
2003: Sarah G Hymowitz; Deanne M Compaan; Minhong Yan; Heidi J A Wallweber; Xiaodong Huang; Melissa A Starovasnik; Abraham M de Vos
The crystal structures of EDA-A1 and EDA-A2: splice variants with distinct receptor specificity.
Structure (London, England : 1993) 2003;11(12):1513-20.
2003: Nathaniel C Gordon; Borlan Pan; Sarah G Hymowitz; JianPing Yin; Robert F Kelley; Andrea G Cochran; Minhong Yan; Xiaodong Huang; Wayne J Fairbrother; Melissa A Starovasnik
BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site.
Biochemistry 2003;42(20):5977-83.
2001: Sarah G Hymowitz; Ellen H Filvaroff; Jian Ping Yin; Asuka Morimoto; Liping Cai; P Risser; M Maruoka; Weiguang Mao; Jessica Foster; Robert F Kelley; Guohua Pan; Austin Gurney; Abraham M de Vos; Melissa A Starovasnik
IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.
The EMBO journal 2001;20(19):5332-41.
2000: Minhong Yan; L C Wang; Sarah G Hymowitz; Sarah Schilbach; Asuka Morimoto; A Goddard; Abraham M de Vos; Wei-Qiang Gao; Xiaodong Huang
Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors.
Science (New York, N.Y.) 2000;290(5491):523-7.
2000: Sarah G Hymowitz; MP O'Connell; Mark Ultsch; A Hurst; Klara Totpal; Avi Ashkenazi; Abraham M de Vos; Robert F Kelley
A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL.
Biochemistry 2000;39(4):633-40.
1999: Sarah G Hymowitz; Hans W Christinger; Germaine Fuh; Mark Ultsch; M O'Connell; Robert F Kelley; Avi Ashkenazi; Abraham M de Vos
Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.
Molecular cell 1999;4(4):563-71.