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Richard Hynes

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
23
Wagner, Denisa
21
Rayburn, Helen
14
Frenette, PS
13
Crowley, Denise
10
Mayadas, Tanya
10
Yang, Joy
9
Hodivala-Dilke, Kairbaan
9
Bronson, Roderick
8
Taverna, Daniela
7
DiPersio, CM
6
Kreidberg, Jordan
6
Lacy-Hulbert, Adam
5
Guan, Jun-Lin
5
Astrof, Sophie
5
Ullman-Culleré, MH

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Publications

TOP 3
Hori Yuki; Stern Patrick J; Hynes Richard O; Irvine Darrell J
Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy.
Sobolev Olga; Stern Patrick; Lacy-Hulbert Adam; Hynes Richard O
Natural killer cells require selectins for suppression of subcutaneous tumors.
Hynes Richard O
US policies on human embryonic stem cells.

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All Publications

2009: Hori Yuki; Stern Patrick J; Hynes Richard O; Irvine Darrell J
Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy.
Biomaterials 2009;30(35):6757-67.
2009: Sobolev Olga; Stern Patrick; Lacy-Hulbert Adam; Hynes Richard O
Natural killer cells require selectins for suppression of subcutaneous tumors.
Cancer research 2009;69(6):2531-9.
2008: Hynes Richard O
US policies on human embryonic stem cells.
Nature reviews. Molecular cell biology 2008;9(12):993-7.
2008: Stern Patrick; Astrof Sophie; Erkeland Stefan J; Schustak Joshua; Sharp Phillip A; Hynes Richard O
A system for Cre-regulated RNA interference in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13895-900.
2008: McCarty Joseph H; Barry Marc; Crowley Denise; Bronson Roderick T; Lacy-Hulbert Adam; Hynes Richard O
Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma.
The American journal of pathology 2008;172(6):1740-7.
2008: Xu Lei; Shen Steven S; Hoshida Yujin; Subramanian Aravind; Ross Ken; Brunet Jean-Philippe; Wagner Stephan N; Ramaswamy Sridhar; Mesirov Jill P; Hynes Richard O
Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases.
Molecular cancer research : MCR 2008;6(5):760-9.
2008: Shinde Arti V; Bystroff Christopher; Wang Chunyu; Vogelezang Mariette G; Vincent Peter A; Hynes Richard O; Van De Water Livingston
Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities.
The Journal of biological chemistry 2008;283(5):2858-70.
2008: Wong Sunny Y; Crowley Denise; Bronson Roderick T; Hynes Richard O
Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer.
Clinical & experimental metastasis 2008;25(2):109-18.
2007: Izawa Atsushi; Ueno Takuya; Jurewicz Mollie; Ito Toshiro; Tanaka Katsunori; Takahashi Masafumi; Ikeda Uichi; Sobolev Olga; Fiorina Paolo; Smith Rex Neal; Hynes Richard O; Abdi Reza
Importance of donor- and recipient-derived selectins in cardiac allograft rejection.
Journal of the American Society of Nephrology : JASN 2007;18(11):2929-36.
2007: Astrof Sophie; Crowley Denise; Hynes Richard O
Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin.
Developmental biology 2007;311(1):11-24.
2007: Lacy-Hulbert Adam; Smith Aileen M; Tissire Hamid; Barry Marc; Crowley Denise; Bronson Roderick T; Roes Jürgen T; Savill John S; Hynes Richard O
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(40):15823-8.
2007: Astrof Sophie; Kirby Andrew; Lindblad-Toh Kerstin; Daly Mark; Hynes Richard O
Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four.
Mechanisms of development 2007;124(7-8):551-8.
2007: Wong Sunny Y; Haack Herbert; Kissil Joseph L; Barry Marc; Bronson Roderick T; Shen Steven S; Whittaker Charles A; Crowley Denise; Hynes Richard O
Protein 4.1B suppresses prostate cancer progression and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(31):12784-9.
2007: Hynes R O
Cell-matrix adhesion in vascular development.
Journal of thrombosis and haemostasis : JTH 2007;5 Suppl 1():32-40.
2007: Wong Sunny Y; Hynes Richard O
Tumor-lymphatic interactions in an activated stromal microenvironment.
Journal of cellular biochemistry 2007;101(4):840-50.
2007: Eshghi Shawdee; Vogelezang Mariette G; Hynes Richard O; Griffith Linda G; Lodish Harvey F
Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development.
The Journal of cell biology 2007;177(5):871-80.
2007: Lacy-Hulbert A; Ueno T; Ito T; Jurewicz M; Izawa A; Smith R N; Chase C M; Tanaka K; Fiorina P; Russell P S; Auchincloss H; Sayegh M H; Hynes R O; Abdi R
Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1080-90.
2007: Xu Lei; Hynes Richard O
GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment.
Cell cycle (Georgetown, Tex.) 2007;6(2):160-5.
2006: Whittaker Charles A; Bergeron Karl-Frederik; Whittle James; Brandhorst Bruce P; Burke Robert D; Hynes Richard O
The echinoderm adhesome.
Developmental biology 2006;300(1):252-66.
2006: Xu Lei; Begum Shahinoor; Hearn Jeremy D; Hynes Richard O
GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9023-8.
2006: Matuskova Jana; Chauhan Anil K; Cambien Beatrice; Astrof Sophie; Dole Vandana S; Piffath Crystal L; Hynes Richard O; Wagner Denisa D
Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(6):1391-6.
2006: Wong Sunny Y; Hynes Richard O
Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide?
Cell cycle (Georgetown, Tex.) 2006;5(8):812-7.
2005: Taverna Daniela; Crowley Denise; Connolly Mary; Bronson Roderick T; Hynes Richard O
A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas.
Cancer research 2005;65(22):10324-9.
2005: Wong Sunny Y; Haack Herbert; Crowley Denise; Barry Marc; Bronson Roderick T; Hynes Richard O
Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis.
Cancer research 2005;65(21):9789-98.
2005: McCarty Joseph H; Cook Aaron A; Hynes Richard O
An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(38):13479-83.
2005: Bono Petri; Cordero Etchell; Johnson Kristen; Borowsky Mark; Ramesh Vijaya; Jacks Tyler; Hynes Richard O
Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin.
Experimental cell research 2005;308(1):177-87.
2005: Reynolds L E; Conti F J; Lucas M; Grose R; Robinson S; Stone M; Saunders G; Dickson C; Hynes R O; Lacy-Hulbert A; Hodivala-Dilke K
Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling.
Nature medicine 2005;11(2):167-74.
2005: McCarty Joseph H; Lacy-Hulbert Adam; Charest Alain; Bronson Roderick T; Crowley Denise; Housman David; Savill John; Roes Jürgen; Hynes Richard O
Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.
Development (Cambridge, England) 2005;132(1):165-76.
2004: Singh Purva; Reimer Corinne L; Peters John H; Stepp Mary Ann; Hynes Richard O; Van De Water Livingston
The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing.
The Journal of investigative dermatology 2004;123(6):1176-81.
2004: Hynes Richard O
The emergence of integrins: a personal and historical perspective.
Matrix biology : journal of the International Society for Matrix Biology 2004;23(6):333-40.
2004: Astrof Sophie; Crowley Denise; George Elizabeth L; Fukuda Tomohiko; Sekiguchi Kiyotoshi; Hanahan Douglas; Hynes Richard O
Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis.
Molecular and cellular biology 2004;24(19):8662-70.
2004: Taverna Daniela; Moher Heather; Crowley Denise; Borsig Lubor; Varki Ajit; Hynes Richard O
Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(3):763-8.
2003: Hynes Richard O
Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both?
Cell 2003;113(7):821-3.
2003: Hynes Richard O
Structural biology. Changing partners.
Science (New York, N.Y.) 2003;300(5620):755-6.
2003: Ni Heyu; Yuen Peter S T; Papalia Jessie M; Trevithick Jane E; Sakai Takao; Fässler Reinhard; Hynes Richard O; Wagner Denisa D
Plasma fibronectin promotes thrombus growth and stability in injured arterioles.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2415-9.
2002: McCarty Joseph H; Monahan-Earley Rita A; Brown Lawrence F; Keller Markus; Gerhardt Holger; Rubin Kristofer; Shani Moshe; Dvorak Harold F; Wolburg Hartwig; Bader Bernhard L; Dvorak Ann M; Hynes Richard O
Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.
Molecular and cellular biology 2002;22(21):7667-77.
2002: Whittaker Charles A; Hynes Richard O
Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.
Molecular biology of the cell 2002;13(10):3369-87.
2002: Hynes Richard O
Integrins: bidirectional, allosteric signaling machines.
Cell 2002;110(6):673-87.
2002: Hynes Richard O
A reevaluation of integrins as regulators of angiogenesis.
Nature medicine 2002;8(9):918-21.
2002: André Patrick; Prasad K S Srinivasa; Denis Cécile V; He Ming; Papalia Jessie M; Hynes Richard O; Phillips David R; Wagner Denisa D
CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism.
Nature medicine 2002;8(3):247-52.
2002: Borsig Lubor; Wong Richard; Hynes Richard O; Varki Nissi M; Varki Ajit
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(4):2193-8.
2002: Alcamo Elizabeth; Hacohen Nir; Schulte Leah C; Rennert Paul D; Hynes Richard O; Baltimore David
Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs.
The Journal of experimental medicine 2002;195(2):233-44.
2002: Reynolds Louise E; Wyder Lorenza; Lively Julie C; Taverna Daniela; Robinson Stephen D; Huang Xiaozhu; Sheppard Dean; Hynes Richard O; Hodivala-Dilke Kairbaan M
Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins.
Nature medicine 2002;8(1):27-34.
2002: Hynes R O; Lively J C; McCarty J H; Taverna D; Francis S E; Hodivala-Dilke K; Xiao Q
The diverse roles of integrins and their ligands in angiogenesis.
Cold Spring Harbor symposia on quantitative biology 2002;67():143-53.
2001: Alcamo E; Mizgerd J P; Horwitz B H; Bronson R; Beg A A; Scott M; Doerschuk C M; Hynes R O; Baltimore D
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(3):1592-600.
2001: DiPersio C M; Trevithick J E; Hynes R O
Functional comparison of the alpha3A and alpha3B cytoplasmic domain variants of the chicken alpha3 integrin subunit.
Experimental cell research 2001;268(1):45-60.
2001: Taverna D; Hynes R O
Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies.
Cancer research 2001;61(13):5255-61.
2001: Haack H; Hynes R O
Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage.
Developmental biology 2001;233(1):38-55.
2001: Bono P; Rubin K; Higgins J M; Hynes R O
Layilin, a novel integral membrane protein, is a hyaluronan receptor.
Molecular biology of the cell 2001;12(4):891-900.
2001: Wheeler G N; Hynes R O
The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila.
Gene 2001;262(1-2):291-9.
2000: André P; Denis C V; Ware J; Saffaripour S; Hynes R O; Ruggeri Z M; Wagner D D
Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins.
Blood 2000;96(10):3322-8.
2000: Arroyo A G; Taverna D; Whittaker C A; Strauch U G; Bader B L; Rayburn H; Crowley D; Parker C M; Hynes R O
In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for alpha 5, alpha v, and alpha 4 integrins.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(8):4667-75.
2000: DiPersio C M; van der Neut R; Georges-Labouesse E; Kreidberg J A; Sonnenberg A; Hynes R O
alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.
Journal of cell science 2000;113 ( Pt 17)():3051-62.
2000: Clark E A; Golub T R; Lander E S; Hynes R O
Genomic analysis of metastasis reveals an essential role for RhoC.
Nature 2000;406(6795):532-5.
2000: DiPersio C M; Shao M; Di Costanzo L; Kreidberg J A; Hynes R O
Mouse keratinocytes immortalized with large T antigen acquire alpha3beta1 integrin-dependent secretion of MMP-9/gelatinase B.
Journal of cell science 2000;113 ( Pt 16)():2909-21.
2000: Hynes R O; Zhao Q
The evolution of cell adhesion.
The Journal of cell biology 2000;150(2):F89-96.
2000: McHugh K P; Hodivala-Dilke K; Zheng M H; Namba N; Lam J; Novack D; Feng X; Ross F P; Hynes R O; Teitelbaum S L
Mice lacking beta3 integrins are osteosclerotic because of dysfunctional osteoclasts.
The Journal of clinical investigation 2000;105(4):433-40.
1999: Fox G L; Rebay I; Hynes R O
Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):14978-83.
1999: Arroyo A G; Yang J T; Rayburn H; Hynes R O
Alpha4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo.
Immunity 1999;11(5):555-66.
1999: Yang J T; Bader B L; Kreidberg J A; Ullman-Culleré M; Trevithick J E; Hynes R O
Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development.
Developmental biology 1999;215(2):264-77.
1999: Robinson S D; Frenette P S; Rayburn H; Cummiskey M; Ullman-Culleré M; Wagner D D; Hynes R O
Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(20):11452-7.
1999: Hynes R O; Hodivala-Dilke K M
Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia.
Thrombosis and haemostasis 1999;82(2):481-5.
1999: Bloom L; Ingham K C; Hynes R O
Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13.
Molecular biology of the cell 1999;10(5):1521-36.
1999: Anderson R; Fässler R; Georges-Labouesse E; Hynes R O; Bader B L; Kreidberg J A; Schaible K; Heasman J; Wylie C
Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads.
Development (Cambridge, England) 1999;126(8):1655-64.
1999: Hynes R O
The dynamic dialogue between cells and matrices: implications of fibronectin's elasticity.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(6):2588-90.
1999: Tsakiris D A; Scudder L; Hodivala-Dilke K; Hynes R O; Coller B S
Hemostasis in the mouse (Mus musculus): a review.
Thrombosis and haemostasis 1999;81(2):177-88.
1999: Hodivala-Dilke K M; McHugh K P; Tsakiris D A; Rayburn H; Crowley D; Ullman-Culleré M; Ross F P; Coller B S; Teitelbaum S; Hynes R O
Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival.
The Journal of clinical investigation 1999;103(2):229-38.
1998: Bader B L; Rayburn H; Crowley D; Hynes R O
Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins.
Cell 1998;95(4):507-19.
1998: Hartwell D W; Mayadas T N; Berger G; Frenette P S; Rayburn H; Hynes R O; Wagner D D
Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses.
The Journal of cell biology 1998;143(4):1129-41.
1998: Taverna D; Disatnik M H; Rayburn H; Bronson R T; Yang J; Rando T A; Hynes R O
Dystrophic muscle in mice chimeric for expression of alpha5 integrin.
The Journal of cell biology 1998;143(3):849-59.
1998: Borowsky M L; Hynes R O
Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles.
The Journal of cell biology 1998;143(2):429-42.
1998: Hodivala-Dilke K M; DiPersio C M; Kreidberg J A; Hynes R O
Novel roles for alpha3beta1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes.
The Journal of cell biology 1998;142(5):1357-69.
1998: Denis C; Methia N; Frenette P S; Rayburn H; Ullman-Culleré M; Hynes R O; Wagner D D
A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(16):9524-9.
1998: Mazo I B; Gutierrez-Ramos J C; Frenette P S; Hynes R O; Wagner D D; von Andrian U H
Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1.
The Journal of experimental medicine 1998;188(3):465-74.
1998: Clark E A; King W G; Brugge J S; Symons M; Hynes R O
Integrin-mediated signals regulated by members of the rho family of GTPases.
The Journal of cell biology 1998;142(2):573-86.
1998: Dong Z M; Chapman S M; Brown A A; Frenette P S; Hynes R O; Wagner D D
The combined role of P- and E-selectins in atherosclerosis.
The Journal of clinical investigation 1998;102(1):145-52.
1998: Taverna D; Ullman-Culleré M; Rayburn H; Bronson R T; Hynes R O
A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis.
Cancer research 1998;58(4):848-53.
1998: Frenette P S; Moyna C; Hartwell D W; Lowe J B; Hynes R O; Wagner D D
Platelet-endothelial interactions in inflamed mesenteric venules.
Blood 1998;91(4):1318-24.
1998: Hartwell D W; Butterfield C E; Frenette P S; Kenyon B M; Hynes R O; Folkman J; Wagner D D
Angiogenesis in P- and E-selectin-deficient mice.
Microcirculation (New York, N.Y. : 1994) 1998;5(2-3):173-8.
1997: Clark E A; Hynes R O
1997 keystone symposium on signal transduction by cell adhesion receptors.
Biochimica et biophysica acta 1997;1333(3):R9-16.
1997: Hynes R O; Wagner D D
Genetic manipulation of vascular adhesion molecules in mice.
The Journal of clinical investigation 1997;100(11 Suppl):S11-3.
1997: Stark K A; Yee G H; Roote C E; Williams E L; Zusman S; Hynes R O
A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development.
Development (Cambridge, England) 1997;124(22):4583-94.
1997: Radice G L; Ferreira-Cornwell M C; Robinson S D; Rayburn H; Chodosh L A; Takeichi M; Hynes R O
Precocious mammary gland development in P-cadherin-deficient mice.
The Journal of cell biology 1997;139(4):1025-32.
1997: Goh K L; Yang J T; Hynes R O
Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos.
Development (Cambridge, England) 1997;124(21):4309-19.
1997: George E L; Baldwin H S; Hynes R O
Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells.
Blood 1997;90(8):3073-81.
1997: Hynes R O; Bader B L
Targeted mutations in integrins and their ligands: their implications for vascular biology.
Thrombosis and haemostasis 1997;78(1):83-7.
1997: DiPersio C M; Hodivala-Dilke K M; Jaenisch R; Kreidberg J A; Hynes R O
alpha3beta1 Integrin is required for normal development of the epidermal basement membrane.
The Journal of cell biology 1997;137(3):729-42.
1997: Subramaniam M; Saffaripour S; Van De Water L; Frenette P S; Mayadas T N; Hynes R O; Wagner D D
Role of endothelial selectins in wound repair.
The American journal of pathology 1997;150(5):1701-9.
1997: Johnson R C; Chapman S M; Dong Z M; Ordovas J M; Mayadas T N; Herz J; Hynes R O; Schaefer E J; Wagner D D
Absence of P-selectin delays fatty streak formation in mice.
The Journal of clinical investigation 1997;99(5):1037-43.
1997: Radice G L; Rayburn H; Matsunami H; Knudsen K A; Takeichi M; Hynes R O
Developmental defects in mouse embryos lacking N-cadherin.
Developmental biology 1997;181(1):64-78.
1996: Hynes R O
Targeted mutations in cell adhesion genes: what have we learned from them?
Developmental biology 1996;180(2):402-12.
1996: Hynes R O; Wagner D D
Genetic manipulation of vascular adhesion molecules in mice.
The Journal of clinical investigation 1996;98(10):2193-5.
1996: Yang J T; Hynes R O
Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins.
Molecular biology of the cell 1996;7(11):1737-48.
1996: Yang J T; Rando T A; Mohler W A; Rayburn H; Blau H M; Hynes R O
Genetic analysis of alpha 4 integrin functions in the development of mouse skeletal muscle.
The Journal of cell biology 1996;135(3):829-35.
1996: Georges-Labouesse E N; George E L; Rayburn H; Hynes R O
Mesodermal development in mouse embryos mutant for fibronectin.
Developmental dynamics : an official publication of the American Association of Anatomists 1996;207(2):145-56.
1996: Arroyo A G; Yang J T; Rayburn H; Hynes R O
Differential requirements for alpha4 integrins during fetal and adult hematopoiesis.
Cell 1996;85(7):997-1008.
1996: Clark E A; Hynes R O
Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A2 but not for cytoskeletal organization.
The Journal of biological chemistry 1996;271(25):14814-8.
1996: Tang T; Frenette P S; Hynes R O; Wagner D D; Mayadas T N
Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.
The Journal of clinical investigation 1996;97(11):2485-90.
1996: Frenette P S; Mayadas T N; Rayburn H; Hynes R O; Wagner D D
Double knockout highlights value of endothelial selectins.
Immunology today 1996;17(5):205.
1996: Mayadas T N; Mendrick D L; Brady H R; Tang T; Papayianni A; Assmann K J; Wagner D D; Hynes R O; Cotran R S
Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice.
Kidney international 1996;49(5):1342-9.
1996: Subramaniam M; Frenette P S; Saffaripour S; Johnson R C; Hynes R O; Wagner D D
Defects in hemostasis in P-selectin-deficient mice.
Blood 1996;87(4):1238-42.
1996: Frenette P S; Mayadas T N; Rayburn H; Hynes R O; Wagner D D
Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.
Cell 1996;84(4):563-74.
1995: Zhang S; Holmes T C; DiPersio C M; Hynes R O; Su X; Rich A
Self-complementary oligopeptide matrices support mammalian cell attachment.
Biomaterials 1995;16(18):1385-93.
1995: Frenette P S; Johnson R C; Hynes R O; Wagner D D
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(16):7450-4.
1995: Johnson R C; Mayadas T N; Frenette P S; Mebius R E; Subramaniam M; Lacasce A; Hynes R O; Wagner D D
Blood cell dynamics in P-selectin-deficient mice.
Blood 1995;86(3):1106-14.
1995: DiPersio C M; Shah S; Hynes R O
alpha 3A beta 1 integrin localizes to focal contacts in response to diverse extracellular matrix proteins.
Journal of cell science 1995;108 ( Pt 6)():2321-36.
1995: Subramaniam M; Saffaripour S; Watson S R; Mayadas T N; Hynes R O; Wagner D D
Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice.
The Journal of experimental medicine 1995;181(6):2277-82.
1995: Yang J T; Rayburn H; Hynes R O
Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development.
Development (Cambridge, England) 1995;121(2):549-60.
1995: Peters J H; Trevithick J E; Johnson P; Hynes R O
Expression of the alternatively spliced EIIIB segment of fibronectin.
Cell adhesion and communication 1995;3(1):67-89.
1994: Gotwals P J; Fessler L I; Wehrli M; Hynes R O
Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11447-51.
1994: Gotwals P J; Paine-Saunders S E; Stark K A; Hynes R O
Drosophila integrins and their ligands.
Current opinion in cell biology 1994;6(5):734-9.
1994: Stepp M A; Urry L A; Hynes R O
Expression of alpha 4 integrin mRNA and protein and fibronectin in the early chicken embryo.
Cell adhesion and communication 1994;2(4):359-75.
1994: Hynes R O
Genetic analyses of cell-matrix interactions in development.
Current opinion in genetics & development 1994;4(4):569-74.
1994: Spring J; Paine-Saunders S E; Hynes R O; Bernfield M
Drosophila syndecan: conservation of a cell-surface heparan sulfate proteoglycan.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(8):3334-8.
1994: Grinblat Y; Zusman S; Yee G; Hynes R O; Kafatos F C
Functions of the cytoplasmic domain of the beta PS integrin subunit during Drosophila development.
Development (Cambridge, England) 1994;120(1):91-102.
1993: George E L; Georges-Labouesse E N; Patel-King R S; Rayburn H; Hynes R O
Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.
Development (Cambridge, England) 1993;119(4):1079-91.
1993: Yang J T; Rayburn H; Hynes R O
Embryonic mesodermal defects in alpha 5 integrin-deficient mice.
Development (Cambridge, England) 1993;119(4):1093-105.
1993: Huh G S; Hynes R O
Elements regulating an alternatively spliced exon of the rat fibronectin gene.
Molecular and cellular biology 1993;13(9):5301-14.
1993: Mayadas T N; Johnson R C; Rayburn H; Hynes R O; Wagner D D
Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice.
Cell 1993;74(3):541-54.
1993: Yee G H; Hynes R O
A novel, tissue-specific integrin subunit, beta nu, expressed in the midgut of Drosophila melanogaster.
Development (Cambridge, England) 1993;118(3):845-58.
1993: Zusman S; Grinblat Y; Yee G; Kafatos F C; Hynes R O
Analyses of PS integrin functions during Drosophila development.
Development (Cambridge, England) 1993;118(3):737-50.
1992: Hynes R O
Specificity of cell adhesion in development: the cadherin superfamily.
Current opinion in genetics & development 1992;2(4):621-4.
1992: Hynes R O
Integrins: versatility, modulation, and signaling in cell adhesion.
Cell 1992;69(1):11-25.
1992: Hynes R O; Lander A D
Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons.
Cell 1992;68(2):303-22.
1992: Hynes R O; George E L; Georges E N; Guan J L; Rayburn H; Yang J T
Toward a genetic analysis of cell-matrix adhesion.
Cold Spring Harbor symposia on quantitative biology 1992;57():249-58.
1991: Guan J L; Trevithick J E; Hynes R O
Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein.
Cell regulation 1991;2(11):951-64.
1990: Rees D J; Ades S E; Singer S J; Hynes R O
Sequence and domain structure of talin.
Nature 1990;347(6294):685-9.
1990: Marcantonio E E; Guan J L; Trevithick J E; Hynes R O
Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.
Cell regulation 1990;1(8):597-604.
1990: Zusman S; Patel-King R S; Ffrench-Constant C; Hynes R O
Requirements for integrins during Drosophila development.
Development (Cambridge, England) 1990;108(3):391-402.
1990: Guan J L; Trevithick J E; Hynes R O
Retroviral expression of alternatively spliced forms of rat fibronectin.
The Journal of cell biology 1990;110(3):833-47.
1990: Guan J L; Hynes R O
Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1.
Cell 1990;60(1):53-61.
1989: Lawler J; Hynes R O
An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin.
Blood 1989;74(6):2022-7.
1989: Solowska J; Guan J L; Marcantonio E E; Trevithick J E; Buck C A; Hynes R O
Expression of normal and mutant avian integrin subunits in rodent cells.
The Journal of cell biology 1989;109(2):853-61.
1989: Ffrench-Constant C; Van de Water L; Dvorak H F; Hynes R O
Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat.
The Journal of cell biology 1989;109(2):903-14.
1989: Hynes R O; Marcantonio E E; Stepp M A; Urry L A; Yee G H
Integrin heterodimer and receptor complexity in avian and mammalian cells.
The Journal of cell biology 1989;109(1):409-20.
1989: Plantefaber L C; Hynes R O
Changes in integrin receptors on oncogenically transformed cells.
Cell 1989;56(2):281-90.
1988: Ffrench-Constant C; Hynes R O
Patterns of fibronectin gene expression and splicing during cell migration in chicken embryos.
Development (Cambridge, England) 1988;104(3):369-82.
1988: Marcantonio E E; Hynes R O
Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi.
The Journal of cell biology 1988;106(5):1765-72.
1988: DeSimone D W; Hynes R O
Xenopus laevis integrins. Structural conservation and evolutionary divergence of integrin beta subunits.
The Journal of biological chemistry 1988;263(11):5333-40.
1987: Norton P A; Hynes R O
Alternative splicing of chicken fibronectin in embryos and in normal and transformed cells.
Molecular and cellular biology 1987;7(12):4297-307.
1987: DeSimone D W; Stepp M A; Patel R S; Hynes R O
The integrin family of cell surface receptors.
Biochemical Society transactions 1987;15(5):789-91.
1987: Patel R S; Odermatt E; Schwarzbauer J E; Hynes R O
Organization of the fibronectin gene provides evidence for exon shuffling during evolution.
The EMBO journal 1987;6(9):2565-72.
1987: Schwarzbauer J E; Patel R S; Fonda D; Hynes R O
Multiple sites of alternative splicing of the rat fibronectin gene transcript.
The EMBO journal 1987;6(9):2573-80.
1986: Tamkun J W; DeSimone D W; Fonda D; Patel R S; Buck C; Horwitz A F; Hynes R O
Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin.
Cell 1986;46(2):271-82.

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