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Kullervo Hynynen

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Margarita Todorova; Vlad Agache; Branson Chen; Kullervo Hynynen; Raffi Karshafian; Robert S Kerbel; Shan Man; Omid Mortazavi; David E Goertz
Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles.
Alison Burgess; Yuexi Huang; William Querbes; Dinah W Sah; Kullervo Hynynen
Non-invasive delivery of small interfering ribonucleic acid for reduction of Huntingtin expression in the brain is achieved using focused ultrasound to disrupt the blood-brain barrier.
Ryan Jones; Meaghan O'Reilly; Kullervo Hynynen
Simulations of transcranial passive acoustic mapping with hemispherical sparse arrays using computed tomography-based aberration corrections.

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2013: Margarita Todorova; Vlad Agache; Branson Chen; Kullervo Hynynen; Raffi Karshafian; Robert S Kerbel; Shan Man; Omid Mortazavi; David E Goertz
Antitumor effects of combining metronomic chemotherapy with the antivascular action of ultrasound stimulated microbubbles.
International journal of cancer. Journal international du cancer 2013;132(12):2956-66.
2013: Alison Burgess; Yuexi Huang; William Querbes; Dinah W Sah; Kullervo Hynynen
Non-invasive delivery of small interfering ribonucleic acid for reduction of Huntingtin expression in the brain is achieved using focused ultrasound to disrupt the blood-brain barrier.
The Journal of the Acoustical Society of America 2013;133(5):3408.
2013: Ryan Jones; Meaghan O'Reilly; Kullervo Hynynen
Simulations of transcranial passive acoustic mapping with hemispherical sparse arrays using computed tomography-based aberration corrections.
The Journal of the Acoustical Society of America 2013;133(5):3262.
2013: Nir Lipsman; Tejas Sankar; Michael L Schwartz; Martin Chapman; Yuexi Huang; Kullervo Hynynen; Liesly Lee; Andres M Lozano
MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study.
Lancet neurology 2013;12(5):462-8.
2013: Alison Burgess; Kullervo Hynynen
Noninvasive and targeted drug delivery to the brain using focused ultrasound.
ACS chemical neuroscience 2013;4(4):519-26.
2013: Ryan Alkins; Alison Burgess; Giulio Francia; Milan Ganguly; Robert Kerbel; Winfried S Wels; Kullervo Hynynen
Focused ultrasound delivers targeted immune cells to metastatic brain tumors.
Cancer research 2013;73(6):1892-9.
2013: Benjamin Lucht; Austin Hubbell; Kullervo Hynynen
Contrast-enhanced transcranial two-dimensional ultrasound imaging using shear-mode conversion at low frequency.
Ultrasound in medicine & biology 2013;39(2):332-44.
2012: Emmanuel Thévenot; Ying-Qi Weng; Kevin D Foust; Kullervo Hynynen; Jessica F Jordão; Brian K Kaspar; Kelly Markham; Meaghan A O'Reilly; Isabelle Aubert
Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.
Human gene therapy 2012;23(11):1144-55.
2012: Lisa H Treat; Natalia Vykhodtseva; Yongzhi Zhang; Nathan McDannold; Kullervo Hynynen
Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma.
Ultrasound in medicine & biology 2012;38(10):1716-25.
2012: Arnold B Etame; Kullervo Hynynen; Todd G Mainprize; Meaghan A O'Reilly; Roberto J Diaz; Christian A Smith; James T Rutka
Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound.
Nanomedicine : nanotechnology, biology, and medicine 2012;8(7):1133-42.
2012: Daniel Pajek; Kullervo Hynynen
The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study.
Physics in medicine and biology 2012;57(15):4951-68.
2012: Junho Song; Benjamin Lucht; Kullervo Hynynen
Large improvement of the electrical impedance of imaging and high-intensity focused ultrasound (HIFU) phased arrays using multilayer piezoelectric ceramics coupled in lateral mode.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2012;59(7):1584-95.
2012: Jarkko J Leskinen; Kullervo Hynynen
Study of factors affecting the magnitude and nature of ultrasound exposure with in vitro set-ups.
Ultrasound in medicine & biology 2012;38(5):777-94.
2012: Douglas L Miller; Nadine B Smith; Michael R Bailey; Gregory J Czarnota; Kullervo Hynynen; Inder Raj S Makin
Overview of therapeutic ultrasound applications and safety considerations.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2012;31(4):623-34.
2012: Robert Staruch; Rajiv Chopra; Kullervo Hynynen
Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery.
Radiology 2012;263(1):117-27.
2012: Cameron Wright; Kullervo Hynynen; David Goertz
In vitro and in vivo high-intensity focused ultrasound thrombolysis.
Investigative radiology 2012;47(4):217-25.
2012: Meaghan A O'Reilly; Kullervo Hynynen
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller.
Radiology 2012;263(1):96-106.
2012: Cameron C Wright; Kullervo Hynynen; David E Goertz
Pulsed focused ultrasound-induced displacements in confined in vitro blood clots.
IEEE transactions on bio-medical engineering 2012;59(3):842-51.
2012: Junho Song; Aki Pulkkinen; Yuexi Huang; Kullervo Hynynen
Investigation of standing-wave formation in a human skull for a clinical prototype of a large-aperture, transcranial MR-guided focused ultrasound (MRgFUS) phased array: an experimental and simulation study.
IEEE transactions on bio-medical engineering 2012;59(2):435-44.
2012: Chang-Sheng Mei; Robert V Mulkern; Koichi Oshio; Lawrence P Panych; Nan-Kuei Chen; Kullervo Hynynen; Bruno Madore; Nathan J McDannold
Ultrafast 1D MR thermometry using phase or frequency mapping.
Magma (New York, N.Y.) 2012;25(1):5-14.
2012: David E Goertz; Vlad Agache; Branson Chen; Raffi Karshafian; Omid Mortazavi; Margarita Todorova; Kullervo Hynynen
Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles.
PloS one 2012;7(12):e52307.
2012: Robert M Staruch; Ian F Tannock; Milan Ganguly; Kullervo Hynynen; Rajiv Chopra
Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2012;28(8):776-87.
2012: Alison Burgess; Milan Ganguly; David E Goertz; Yuexi Huang; Adam C Waspe; Kullervo Hynynen
High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke.
PloS one 2012;7(8):e42311.
2012: Meaghan A O'Reilly; Kullervo Hynynen
Ultrasound enhanced drug delivery to the brain and central nervous system.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2012;28(4):386-96.
2012: Meaghan A O'Reilly; Adam C Waspe; Rajiv Chopra; Kullervo Hynynen
MRI-guided disruption of the blood-brain barrier using transcranial focused ultrasound in a rat model.
Journal of visualized experiments : JoVE 2012;(61):.
2011: Meaghan A O'Reilly; Aidan Muller; Kullervo Hynynen
Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies.
Ultrasound in medicine & biology 2011;37(11):1930-7.
2011: Kullervo Hynynen
MRIgHIFU: a tool for image-guided therapeutics.
Journal of magnetic resonance imaging : JMRI 2011;34(3):482-93.
2011: Eunice E Cho; Jelena Drazic; Milan Ganguly; Bojana Stefanovic; Kullervo Hynynen
Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2011;31(9):1852-62.
2011: Nicholas Ellens; Aki Pulkkinen; Junho Song; Kullervo Hynynen
The utility of sparse 2D fully electronically steerable focused ultrasound phased arrays for thermal surgery: a simulation study.
Physics in medicine and biology 2011;56(15):4913-32.
2011: Aki Pulkkinen; Junho Song; Yuexi Huang; Kullervo Hynynen
Simulations and measurements of transcranial low-frequency ultrasound therapy: skull-base heating and effective area of treatment.
Physics in medicine and biology 2011;56(15):4661-83.
2011: Laura Curiel; Kullervo Hynynen
Localized harmonic motion imaging for focused ultrasound surgery targeting.
Ultrasound in medicine & biology 2011;37(8):1230-9.
2011: Clare M C Tempany; Nathan McDannold; Kullervo Hynynen; Ferenc A Jolesz
Focused ultrasound surgery in oncology: overview and principles.
Radiology 2011;259(1):39-56.
2011: Meaghan A O'Reilly; Adam C Waspe; Milan Ganguly; Kullervo Hynynen
Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate.
Ultrasound in medicine & biology 2011;37(4):587-94.
2011: Alison Burgess; Isabelle Aubert; Kullervo Hynynen
Focused ultrasound: crossing barriers to treat Alzheimer's disease.
Therapeutic delivery 2011;2(3):281-6.
2011: Mark Hurwitz; Jorgen L Hansen; Savina Prokopios-Davos; Judith Manola; Qian Wang; Bruce A Bornstein; Kullervo Hynynen; Irving D Kaplan
Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153.
Cancer 2011;117(3):510-6.
2011: Samuel Pichardo; Vivian W Sin; Kullervo Hynynen
Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls.
Physics in medicine and biology 2011;56(1):219-50.
2011: Munir M El-Desouki; Kullervo Hynynen
Driving circuitry for focused ultrasound noninvasive surgery and drug delivery applications.
Sensors (Basel, Switzerland) 2011;11(1):539-56.
2011: Alison Burgess; Milan Ganguly; Isabelle Aubert; Carlos A Ayala-Grosso; Jessica F Jordão; Kullervo Hynynen
Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier.
PloS one 2011;6(11):e27877.
2011: Yuexi Huang; Kullervo Hynynen
MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption.
Methods in molecular biology (Clifton, N.J.) 2011;711():579-93.
2011: Robert Staruch; Rajiv Chopra; Kullervo Hynynen
Localised drug release using MRI-controlled focused ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2011;27(2):156-71.
2010: Meaghan A O'Reilly; Yuexi Huang; Kullervo Hynynen
The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model.
Physics in medicine and biology 2010;55(18):5251-67.
2010: Kelly C Schad; Kullervo Hynynen
In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy.
Physics in medicine and biology 2010;55(17):4933-47.
2010: Meaghan A O'Reilly; Kullervo Hynynen
A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy.
IEEE transactions on bio-medical engineering 2010;57(9):2286-94.
2010: Anu Olkku; Jarkko J Leskinen; Mikko Juhani Lammi; Kullervo Hynynen; Anitta Mahonen
Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells.
Bone 2010;47(2):320-30.
2010: David E Goertz; Cameron Wright; Kullervo Hynynen
Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound.
Ultrasound in medicine & biology 2010;36(6):916-24.
2010: Alexander R Klotz; Liis Lindvere; Bojana Stefanovic; Kullervo Hynynen
Temperature change near microbubbles within a capillary network during focused ultrasound.
Physics in medicine and biology 2010;55(6):1549-61.
2010: Kullervo Hynynen
Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International Journal of Hyperthermia 1987;3:21-35.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2010;26(1):12-5.
2010: Kullervo Hynynen; Robert B Roemer; D Anhalt; C Johnson; Z X Xu; W Swindell; T Cetas
A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments. 1987.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2010;26(1):1-11.
2010: Nathan McDannold; Greg T Clement; Peter Black; Ferenc Jolesz; Kullervo Hynynen
Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients.
Neurosurgery 2010;66(2):323-32; discussion 332.
2010: Kullervo Hynynen
MRI-guided focused ultrasound treatments.
Ultrasonics 2010;50(2):221-9.
2010: Shahrzad Jalali; Yuexi Huang; Daniel J Dumont; Kullervo Hynynen
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats.
BMC neurology 2010;10():114.
2010: Jessica F Jordão; Carlos A Ayala-Grosso; Kelly Markham; Yuexi Huang; Rajiv Chopra; JoAnne McLaurin; Kullervo Hynynen; Isabelle Aubert
Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.
PloS one 2010;5(5):e10549.
2010: Janne Heikkilä; Laura Curiel; Kullervo Hynynen
Local harmonic motion monitoring of focused ultrasound surgery--a simulation model.
IEEE transactions on bio-medical engineering 2010;57(1):185-93.
2010: Junho Song; Kullervo Hynynen
Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy.
IEEE transactions on bio-medical engineering 2010;57(1):124-33.
2009: Vincent Colucci; Gary Strichartz; Ferenc Jolesz; Natalia Vykhodtseva; Kullervo Hynynen
Focused ultrasound effects on nerve action potential in vitro.
Ultrasound in medicine & biology 2009;35(10):1737-47.
2009: Laura Curiel; Yuexi Huang; Natalia Vykhodtseva; Kullervo Hynynen
Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion.
Physics in medicine and biology 2009;54(11):3405-19.
2009: Yuexi Huang; Laura Curiel; Aleksandra Kukic; Donald B Plewes; Rajiv Chopra; Kullervo Hynynen
MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking.
Medical physics 2009;36(6):2016-20.
2009: Rajiv Chopra; Laura Curiel; Robert Staruch; Laetitia Morrison; Kullervo Hynynen
An MRI-compatible system for focused ultrasound experiments in small animal models.
Medical physics 2009;36(5):1867-74.
2009: Ali Yousefi; David E Goertz; Kullervo Hynynen
Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques.
IEEE transactions on medical imaging 2009;28(5):763-74.
2009: Kullervo Hynynen; Jianhua Yin
Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2009;56(3):557-64.
2009: Magdalini C Pilatou; Elizabeth A Stewart; Stephan E Maier; Fiona M Fennessy; Kullervo Hynynen; Clare M C Tempany; Nathan McDannold
MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids.
Journal of magnetic resonance imaging : JMRI 2009;29(2):404-11.
2008: Janne Heikkilä; Kullervo Hynynen
Simulations of lesion detection using a combined phased array LHMI-technique.
Ultrasonics 2008;48(6-7):568-73.
2008: Nathan McDannold; Clare M C Tempany; Ferenc Jolesz; Kullervo Hynynen
Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids.
Journal of magnetic resonance imaging : JMRI 2008;28(4):1026-32.
2008: Zsuzsanna Lénárd; Nathan McDannold; Fiona M Fennessy; Elizabeth A Stewart; Ferenc A Jolesz; Kullervo Hynynen; Clare M C Tempany
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success.
Radiology 2008;249(1):187-94.
2008: Natalia Vykhodtseva; Nathan McDannold; Kullervo Hynynen
Progress and problems in the application of focused ultrasound for blood-brain barrier disruption.
Ultrasonics 2008;48(4):279-96.
2008: Nickolai Sheikov; Nathan McDannold; Shipra Sharma; Kullervo Hynynen
Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium.
Ultrasound in medicine & biology 2008;34(7):1093-104.
2008: Kullervo Hynynen
Ultrasound for drug and gene delivery to the brain.
Advanced drug delivery reviews 2008;60(10):1209-17.
2008: Nathan McDannold; Natalia Vykhodtseva; Kullervo Hynynen
Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption.
Ultrasound in medicine & biology 2008;34(6):930-7.
2008: Nathan McDannold; Natalia Vykhodtseva; Kullervo Hynynen
Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index.
Ultrasound in medicine & biology 2008;34(5):834-40.
2008: Jarkko J Leskinen; Hannu M Karjalainen; Anu Olkku; Kullervo Hynynen; Anitta Mahonen; Mikko Juhani Lammi
Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound.
Biorheology 2008;45(3-4):345-54.
2008: Scott B Raymond; Lisa H Treat; Jonathan D Dewey; Nathan J McDannold; Kullervo Hynynen; Brian J Bacskai
Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models.
PloS one 2008;3(5):e2175.
2007: Samuel Pichardo; Kullervo Hynynen
Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study.
Physics in medicine and biology 2007;52(24):7313-32.
2007: Laura Curiel; Rajiv Chopra; Kullervo Hynynen
Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging.
IEEE transactions on medical imaging 2007;26(12):1740-6.
2007: Nathan McDannold; Agnieszka Szot Barnes; Frank J Rybicki; Koichi Oshio; Nan-Kuei Chen; Kullervo Hynynen; Robert V Mulkern
Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2007;58(6):1117-23.
2007: Elisabetta Sassaroli; Kullervo Hynynen
Cavitation threshold of microbubbles in gel tunnels by focused ultrasound.
Ultrasound in medicine & biology 2007;33(10):1651-60.
2007: Sai Chun Tang; Gregory T Clement; Kullervo Hynynen
A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2007;54(9):1772-83.
2007: Samuel Pichardo; Kullervo Hynynen
Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study.
Physics in medicine and biology 2007;52(16):4923-42.
2007: Lisa H Treat; Nathan McDannold; Natalia Vykhodtseva; Yongzhi Zhang; Karen Tam; Kullervo Hynynen
Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound.
International journal of cancer. Journal international du cancer 2007;121(4):901-7.
2007: Manabu Kinoshita; Kullervo Hynynen
Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation.
Biochemical and biophysical research communications 2007;359(4):860-5.
2007: P Jason White; Sonali Palchaudhuri; Kullervo Hynynen; Greg T Clement
The effects of desiccation on skull bone sound speed in porcine models.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2007;54(8):1708-10.
2007: Leslie L Muldoon; Carole Soussain; Kristoph Jahnke; Conrad Johanson; Tali Siegal; Quentin R Smith; Walter A Hall; Kullervo Hynynen; Peter D Senter; David M Peereboom; Edward A Neuwelt
Chemotherapy delivery issues in central nervous system malignancy: a reality check.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2295-305.
2007: Fiona M Fennessy; Clare M C Tempany; Nathan McDannold; Minna J So; Gina Hesley; Bobbie Gostout; Hyun S Kim; George A Holland; Dennis A Sarti; Kullervo Hynynen; Ferenc A Jolesz; Elizabeth A Stewart
Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols.
Radiology 2007;243(3):885-93.
2007: R Erich Caulfield; Xiangtao Yin; Jose Juste; Kullervo Hynynen
A novel phase assignment protocol and driving system for a high-density focused ultrasound array.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2007;54(4):793-801.
2007: Nathan McDannold; Natalia Vykhodtseva; Kullervo Hynynen
Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study.
Ultrasound in medicine & biology 2007;33(4):584-90.
2007: Kullervo Hynynen; G Clement
Clinical applications of focused ultrasound-the brain.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2007;23(2):193-202.
2007: Manabu Kinoshita; Yutaka Eguchi; Kullervo Hynynen
Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2.
Biochemical and biophysical research communications 2007;353(2):515-21.
2007: Scott B Raymond; Jesse Skoch; Brian J Bacskai; Kullervo Hynynen
Modular design for in vivo optical imaging and ultrasound treatment in the murine brain.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2007;54(2):431-4.
2007: Scott B Raymond; Jesse Skoch; Kullervo Hynynen; Brian J Bacskai
Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007;27(2):393-403.
2007: Kullervo Hynynen
Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain.
Expert opinion on drug delivery 2007;4(1):27-35.
2006: Natalia Vykhodtseva; Nathan McDannold; Kullervo Hynynen
Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison.
Ultrasound in medicine & biology 2006;32(12):1923-9.
2006: Nathan McDannold; Kullervo Hynynen
Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience.
Medical physics 2006;33(11):4307-13.
2006: Nathan McDannold; Natalia Vykhodtseva; Kullervo Hynynen
Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits.
Radiology 2006;241(1):95-106.
2006: Janne Heikkilä; Tero Karjalainen; Marko Vauhkonen; Kullervo Hynynen
Simulations of localized harmonic motions on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography.
Physics in medicine and biology 2006;51(18):4587-601.
2006: Simon Dimaio; Neculai Archip; Nobuhiko Hata; Ion-Florin Talos; Simon K Warfield; Amit Majumdar; Nathan McDannold; Kullervo Hynynen; Paul R Morrison; William M Wells; Daniel Kacher; Randy E Ellis; Alexandra J Golby; Peter Black; Ferenc A Jolesz; Ron Kikinis
Image-guided neurosurgery at Brigham and Women's Hospital.
IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 2006;25(5):67-73.
2006: Nickolai Sheikov; Nathan McDannold; Ferenc A Jolesz; Yong-Zhi Zhang; Karen Tam; Kullervo Hynynen
Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier.
Ultrasound in medicine & biology 2006;32(9):1399-409.
2006: Kullervo Hynynen; Nathan McDannold; Natalia Vykhodtseva; Scott Raymond; Ralph Weissleder; Ferenc A Jolesz; Nickolai Sheikov
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.
Journal of neurosurgery 2006;105(3):445-54.
2006: Manabu Kinoshita; Nathan McDannold; Ferenc A Jolesz; Kullervo Hynynen
Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11719-23.
2006: Minna J So; Fiona M Fennessy; Kelly H Zou; Nathan McDannold; Kullervo Hynynen; Ferenc A Jolesz; Elizabeth A Stewart; Frank J Rybicki; Clare M C Tempany
Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?
European journal of radiology 2006;59(2):203-7.
2006: Kullervo Hynynen; Nathan McDannold; Gregory T Clement; Ferenc A Jolesz; Eyal Zadicario; Ronald J Killiany; Tara Moore; Douglas Rosen
Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.
European journal of radiology 2006;59(2):149-56.
2006: P Jason White; Gregory T Clement; Kullervo Hynynen
Longitudinal and shear mode ultrasound propagation in human skull bone.
Ultrasound in medicine & biology 2006;32(7):1085-96.
2006: Nathan McDannold; Clare M C Tempany; Fiona M Fennessy; Minna J So; Frank J Rybicki; Elizabeth A Stewart; Ferenc A Jolesz; Kullervo Hynynen
Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation.
Radiology 2006;240(1):263-72.
2006: Xiangtao Yin; Laurence M Epstein; Kullervo Hynynen
Noninvasive transesophageal cardiac thermal ablation using a 2-D focused, ultrasound phased array: a simulation study.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2006;53(6):1138-49.
2006: P Jason White; Gregory T Clement; Kullervo Hynynen
Local frequency dependence in transcranial ultrasound transmission.
Physics in medicine and biology 2006;51(9):2293-305.
2006: Janne Heikkilä; Kullervo Hynynen
Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study.
Ultrasonic imaging 2006;28(2):97-113.
2006: Manabu Kinoshita; Kullervo Hynynen
Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia.
Radiation research 2006;165(3):299-306.
2006: Manabu Kinoshita; Nathan McDannold; Ferenc A Jolesz; Kullervo Hynynen
Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound.
Biochemical and biophysical research communications 2006;340(4):1085-90.
2006: Nathan McDannold; Natalia Vykhodtseva; Kullervo Hynynen
Targeted disruption of the blood-brain barrier with focused ultrasound: association with cavitation activity.
Physics in medicine and biology 2006;51(4):793-807.
2006: Milla Kopakkala-Tani; Jarkko J Leskinen; Hannu M Karjalainen; Tero Karjalainen; Kullervo Hynynen; Juha Töyräs; Jukka S Jurvelin; Mikko Juhani Lammi
Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes.
Biorheology 2006;43(3-4):271-82.
2005: Gregory T Clement; J Huttunen; Kullervo Hynynen
Superresolution ultrasound imaging using back-projected reconstruction.
The Journal of the Acoustical Society of America 2005;118(6):3953-60.
2005: Nathan McDannold; Natalia Vykhodtseva; Scott Raymond; Ferenc A Jolesz; Kullervo Hynynen
MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits.
Ultrasound in medicine & biology 2005;31(11):1527-37.
2005: Mark Hurwitz; Irving D Kaplan; Jorgen Hansen; Savina Prokopios-Davos; George P Topulos; Kenneth Wishnow; Judith Manola; Bruce A Bornstein; Kullervo Hynynen
Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2005;21(7):649-56.
2005: Manabu Kinoshita; Kullervo Hynynen
A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound.
Biochemical and biophysical research communications 2005;335(2):393-9.
2005: Jason White; Gregory T Clement; Kullervo Hynynen
Transcranial ultrasound focus reconstruction with phase and amplitude correction.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2005;52(9):1518-22.
2005: Matti Malinen; Tomi Huttunen; Jari P Kaipio; Kullervo Hynynen
Scanning path optimization for ultrasound surgery.
Physics in medicine and biology 2005;50(15):3473-90.
2005: Scott B Raymond; Kullervo Hynynen
Acoustic transmission losses and field alterations due to human scalp hair.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2005;52(8):1415-9.
2005: Ferenc A Jolesz; Kullervo Hynynen; Nathan McDannold; Clare M C Tempany
MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery.
Magnetic resonance imaging clinics of North America 2005;13(3):545-60.
2005: Gregory T Clement; P Jason White; Randy L King; Nathan McDannold; Kullervo Hynynen
A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2005;24(8):1117-25.
2005: Christina E Silcox; Roy Smith; Randy King; Nathan McDannold; Peter Bromley; Kenneth Walsh; Kullervo Hynynen
MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate.
Ultrasound in medicine & biology 2005;31(7):965-70.
2005: Jussi Aarnio; Greg T Clement; Kullervo Hynynen
A new ultrasound method for determining the acoustic phase shifts caused by the skull bone.
Ultrasound in medicine & biology 2005;31(6):771-80.
2005: S D Sokka; T P Gauthier; Kullervo Hynynen
Theoretical and experimental validation of a dual-frequency excitation method for spatial control of cavitation.
Physics in medicine and biology 2005;50(9):2167-79.
2005: Hao-Li Liu; Nathan McDannold; Kullervo Hynynen
Focal beam distortion and treatment planning in abdominal focused ultrasound surgery.
Medical physics 2005;32(5):1270-80.
2005: Manabu Kinoshita; Kullervo Hynynen
Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound.
Pharmaceutical research 2005;22(5):716-20.
2005: Xiangtao Yin; Kullervo Hynynen
A numerical study of transcranial focused ultrasound beam propagation at low frequency.
Physics in medicine and biology 2005;50(8):1821-36.
2005: Gregory T Clement; Kullervo Hynynen
Ultrasound phase-contrast transmission imaging of localized thermal variation and the identification of fat/tissue boundaries.
Physics in medicine and biology 2005;50(7):1585-600.
2005: Tomi Huttunen; Matti Malinen; Jari P Kaipio; Phillip Jason White; Kullervo Hynynen
A full-wave Helmholtz model for continuous-wave ultrasound transmission.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2005;52(3):397-409.
2005: Kullervo Hynynen; Nathan McDannold; Nickolai Sheikov; Ferenc A Jolesz; Natalia Vykhodtseva
Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications.
NeuroImage 2005;24(1):12-20.
2004: Kullervo Hynynen; Nathan McDannold
MRI guided and monitored focused ultrasound thermal ablation methods: a review of progress.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2004;20(7):725-37.
2004: Ferenc A Jolesz; Kullervo Hynynen; Nathan McDannold; David Freundlich; Doron Kopelman
Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound.
Gastroenterology 2004;127(5 Suppl 1):S242-7.
2004: Christopher W Connor; Kullervo Hynynen
Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery.
IEEE transactions on bio-medical engineering 2004;51(10):1693-706.
2004: Amir Abdollahi; Sophie Domhan; Jürgen W Jenne; Mazin Hallaj; Giorgio Dell'Aqua; Martina Mueckenthaler; Alexandra Richter; Heather Martin; Jürgen Debus; Wilhelm Ansorge; Kullervo Hynynen; Peter E Huber
Apoptosis signals in lymphoblasts induced by focused ultrasound.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(12):1413-4.
2004: Nickolai Sheikov; Nathan McDannold; Natalia Vykhodtseva; Ferenc A Jolesz; Kullervo Hynynen
Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.
Ultrasound in medicine & biology 2004;30(7):979-89.
2004: Kullervo Hynynen; Gregory T Clement; Nathan McDannold; Natalia Vykhodtseva; Randy King; P Jason White; Shuki Vitek; Ferenc A Jolesz
500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;52(1):100-7.
2004: E Sassaroli; Kullervo Hynynen
Forced linear oscillations of microbubbles in blood capillaries.
The Journal of the Acoustical Society of America 2004;115(6):3235-43.
2004: Matti Malinen; Tomi Huttunen; Kullervo Hynynen; Jari P Kaipio
Simulation study for thermal dose optimization in ultrasound surgery of the breast.
Medical physics 2004;31(5):1296-307.
2004: Nathan McDannold; Randy L King; Kullervo Hynynen
MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(5):1061-5.
2004: Nathan McDannold; Natalia Vykhodtseva; Ferenc A Jolesz; Kullervo Hynynen
MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;51(5):913-23.
2004: Gregory T Clement; P Jason White; Kullervo Hynynen
Enhanced ultrasound transmission through the human skull using shear mode conversion.
The Journal of the Acoustical Society of America 2004;115(3):1356-64.
2004: Nathan McDannold; Sigrid L Fossheim; Henrik Rasmussen; Heather Martin; Natalia Vykhodtseva; Kullervo Hynynen
Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney.
Radiology 2004;230(3):743-52.
2004: Subha Maruvada; Kullervo Hynynen
Optical monitoring of ultrasound-induced bioeffects in glass catfish.
Ultrasound in medicine & biology 2004;30(1):67-74.
2003: Gregory T Clement; Kullervo Hynynen
Forward planar projection through layered media.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2003;50(12):1689-98.
2003: Tomi Huttunen; Jari P Kaipio; Kullervo Hynynen
Modeling of anomalies due to hydrophones in continuous-wave ultrasound fields.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2003;50(11):1486-500.
2003: Elisa E Konofagou; Kullervo Hynynen
Localized harmonic motion imaging: theory, simulations and experiments.
Ultrasound in medicine & biology 2003;29(10):1405-13.
2003: Tonia Giesecke; Kullervo Hynynen
Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro.
Ultrasound in medicine & biology 2003;29(9):1359-65.
2003: Peter E Huber; Michael J Mann; Luis G Melo; Afshin Ehsan; D Kong; Lunan Zhang; Mojgan Rezvani; Peter Peschke; Ferenc A Jolesz; Victor J Dzau; Kullervo Hynynen
Focused ultrasound (HIFU) induces localized enhancement of reporter gene expression in rabbit carotid artery.
Gene therapy 2003;10(18):1600-7.
2003: Elisa E Konofagou; Jonathan Thierman; Kullervo Hynynen
The use of ultrasound-stimulated acoustic emission in the monitoring of modulus changes with temperature.
Ultrasonics 2003;41(5):337-45.
2003: Nathan McDannold; Mark Moss; Ronald J Killiany; Douglas Rosene; Randy L King; Ferenc A Jolesz; Kullervo Hynynen
MRI-guided focused ultrasound surgery in the brain: tests in a primate model.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2003;49(6):1188-91.
2003: Kagayaki Kuroda; Naoyuki Takei; Robert V Mulkern; Koichi Oshio; Toshiharu Nakai; Tomohisa Okada; Akira Matsumura; Kiyoyuki Yanaka; Kullervo Hynynen; Ferenc A Jolesz
Feasibility of internally referenced brain temperature imaging with a metabolite signal.
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 2003;2(1):17-22.
2003: Kullervo Hynynen; Nathan McDannold; Heather Martin; Ferenc A Jolesz; Natalia Vykhodtseva
The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison).
Ultrasound in medicine & biology 2003;29(3):473-81.
2003: Clare M C Tempany; Elizabeth A Stewart; Nathan McDannold; Bradley J Quade; Ferenc A Jolesz; Kullervo Hynynen
MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.
Radiology 2003;226(3):897-905.
2003: Randy L King; Gregory T Clement; Subha Maruvada; Kullervo Hynynen
Preliminary results using ultrasound transmission for image-guided thermal therapy.
Ultrasound in medicine & biology 2003;29(2):293-9.
2003: Peter A Lewin; Nadine Barrie-Smith; Masao Ide; Kullervo Hynynen; Michael Macdonald
Interlaboratory acoustic power measurement.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2003;22(2):207-13.
2003: S D Sokka; R King; Kullervo Hynynen
MRI-guided gas bubble enhanced ultrasound heating in in vivo rabbit thigh.
Physics in medicine and biology 2003;48(2):223-41.
2003: A Vanne; Kullervo Hynynen
MRI feedback temperature control for focused ultrasound surgery.
Physics in medicine and biology 2003;48(1):31-43.
2003: Kullervo Hynynen; Nathan McDannold; Natalia Vykhodtseva; Ferenc A Jolesz
Non-invasive opening of BBB by focused ultrasound.
Acta neurochirurgica. Supplement 2003;86():555-8.
2002: Christopher W Connor; Greg T Clement; Kullervo Hynynen
A unified model for the speed of sound in cranial bone based on genetic algorithm optimization.
Physics in medicine and biology 2002;47(22):3925-44.
2002: Ferenc A Jolesz; Ion-Florin Talos; Richard B Schwartz; Hatsuho Mamata; Daniel Kacher; Kullervo Hynynen; Nathan McDannold; Pairash Saivironporn; Lei Zao
Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors.
Neuroimaging clinics of North America 2002;12(4):665-83.
2002: Mark Hurwitz; Irving D Kaplan; Jorgen Hansen; Savina Prokopios-Davos; George P Topulos; Kenneth Wishnow; Judith Manola; Bruce A Bornstein; Kullervo Hynynen
Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia.
International journal of radiation oncology, biology, physics 2002;53(4):913-8.
2002: Christopher W Connor; Kullervo Hynynen
Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study.
Physics in medicine and biology 2002;47(11):1911-28.
2002: Greg T Clement; Kullervo Hynynen
Correlation of ultrasound phase with physical skull properties.
Ultrasound in medicine & biology 2002;28(5):617-24.
2002: Ferenc A Jolesz; Kullervo Hynynen
Magnetic resonance image-guided focused ultrasound surgery.
Cancer journal (Sudbury, Mass.) 2002;8 Suppl 1():S100-12.
2002: Gregory T Clement; Kullervo Hynynen
A non-invasive method for focusing ultrasound through the human skull.
Physics in medicine and biology 2002;47(8):1219-36.
2002: Gregory T Clement; Kullervo Hynynen
Micro-receiver guided transcranial beam steering.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 2002;49(4):447-53.
2002: Elisa E Konofagou; Jonathan Thierman; Tero Karjalainen; Kullervo Hynynen
The temperature dependence of ultrasound-stimulated acoustic emission.
Ultrasound in medicine & biology 2002;28(3):331-8.
2002: Nathan McDannold; Randy L King; Ferenc A Jolesz; Kullervo Hynynen
The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain.
Medical physics 2002;29(3):356-65.
2002: Timothy E Vaughan; Kullervo Hynynen
Effects of parameter errors in the simulation of transcranial focused ultrasound.
Physics in medicine and biology 2002;47(1):37-45.
2001: Elisa E Konofagou; Jonathan Thierman; Kullervo Hynynen
A focused ultrasound method for simultaneous diagnostic and therapeutic applications--a simulation study.
Physics in medicine and biology 2001;46(11):2967-84.
2001: N B Smith; J M Temkin; F Shapiro; Kullervo Hynynen
Thermal effects of focused ultrasound energy on bone tissue.
Ultrasound in medicine & biology 2001;27(10):1427-33.
2001: Kullervo Hynynen; Nathan McDannold; Natalia Vykhodtseva; Ferenc A Jolesz
Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits.
Radiology 2001;220(3):640-6.
2001: K Mahoney; T Fjield; Nathan McDannold; Gregory T Clement; Kullervo Hynynen
Comparison of modelled and observed in vivo temperature elevations induced by focused ultrasound: implications for treatment planning.
Physics in medicine and biology 2001;46(7):1785-98.
2001: IM Hallaj; Robin O Cleveland; Kullervo Hynynen
Simulations of the thermo-acoustic lens effect during focused ultrasound surgery.
The Journal of the Acoustical Society of America 2001;109(5 Pt 1):2245-53.
2001: NB Smith; N K Merrilees; M Dahleh; Kullervo Hynynen
Control system for an MRI compatible intracavitary ultrasound array for thermal treatment of prostate disease.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2001;17(3):271-82.
2001: Kullervo Hynynen; O Pomeroy; Darrell N Smith; P E Huber; Nathan McDannold; J Kettenbach; J Baum; Samuel Singer; Ferenc A Jolesz
MR imaging-guided focused ultrasound surgery of fibroadenomas in the breast: a feasibility study.
Radiology 2001;219(1):176-85.
2001: Nathan McDannold; Kullervo Hynynen; Koichi Oshio; Robert V Mulkern
Temperature monitoring with line scan echo planar spectroscopic imaging.
Medical physics 2001;28(3):346-55.
2001: Gregory T Clement; J Sun; Kullervo Hynynen
The role of internal reflection in transskull phase distortion.
Ultrasonics 2001;39(2):109-13.
2001: Nathan McDannold; Kullervo Hynynen; FA Jolesz
MRI monitoring of the thermal ablation of tissue: effects of long exposure times.
Journal of magnetic resonance imaging : JMRI 2001;13(3):421-7.
2001: Natalia Vykhodtseva; Nathan McDannold; Heather Martin; R T Bronson; Kullervo Hynynen
Apoptosis in ultrasound-produced threshold lesions in the rabbit brain.
Ultrasound in medicine & biology 2001;27(1):111-7.
2001: Mark Hurwitz; Irving D Kaplan; G K Svensson; Kullervo Hynynen; M S Hansen
Feasibility and patient tolerance of a novel transrectal ultrasound hyperthermia system for treatment of prostate cancer.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2001;17(1):31-7.
2000: Gregory T Clement; J Sun; T Giesecke; Kullervo Hynynen
A hemisphere array for non-invasive ultrasound brain therapy and surgery.
Physics in medicine and biology 2000;45(12):3707-19.
2000: Nathan McDannold; R L King; FA Jolesz; Kullervo Hynynen
Usefulness of MR imaging-derived thermometry and dosimetry in determining the threshold for tissue damage induced by thermal surgery in rabbits.
Radiology 2000;216(2):517-23.
2000: Natalia Vykhodtseva; V Sorrentino; Ferenc A Jolesz; R T Bronson; Kullervo Hynynen
MRI detection of the thermal effects of focused ultrasound on the brain.
Ultrasound in medicine & biology 2000;26(5):871-80.
2000: Kullervo Hynynen; Nathan McDannold; R V Mulkern; FA Jolesz
Temperature monitoring in fat with MRI.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;43(6):901-4.
2000: Greg T Clement; J White; Kullervo Hynynen
Investigation of a large-area phased array for focused ultrasound surgery through the skull.
Physics in medicine and biology 2000;45(4):1071-83.
2000: K Kuroda; Robert V Mulkern; Koichi Oshio; Lawrence P Panych; T Nakai; T Moriya; Shigeo Okuda; Kullervo Hynynen; F A Jolesz; F A Joles
Temperature mapping using the water proton chemical shift: self-referenced method with echo-planar spectroscopic imaging.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2000;43(2):220-5.
2000: T Fjield; Kullervo Hynynen
Method of reduction of the number of driving system channels for phased-array transducers using isolation transformers.
IEEE transactions on bio-medical engineering 2000;47(1):139-41.
1999: D R Daum; N B Smith; R King; Kullervo Hynynen
In vivo demonstration of noninvasive thermal surgery of the liver and kidney using an ultrasonic phased array.
Ultrasound in medicine & biology 1999;25(7):1087-98.
1999: A H Chung; Ferenc A Jolesz; Kullervo Hynynen
Thermal dosimetry of a focused ultrasound beam in vivo by magnetic resonance imaging.
Medical physics 1999;26(9):2017-26.
1999: T Fjield; C E Silcox; Kullervo Hynynen
Low-profile lenses for ultrasound surgery.
Physics in medicine and biology 1999;44(7):1803-13.
1999: R J Lee; M Buchanan; L J Kleine; Kullervo Hynynen
Arrays of multielement ultrasound applicators for interstitial hyperthermia.
IEEE transactions on bio-medical engineering 1999;46(7):880-90.
1999: Nathan McDannold; Ferenc A Jolesz; Kullervo Hynynen
Determination of the optimal delay between sonications during focused ultrasound surgery in rabbits by using MR imaging to monitor thermal buildup in vivo.
Radiology 1999;211(2):419-26.
1999: NB Smith; M T Buchanan; Kullervo Hynynen
Transrectal ultrasound applicator for prostate heating monitored using MRI thermometry.
International journal of radiation oncology, biology, physics 1999;43(1):217-25.
1998: E B Hutchinson; Kullervo Hynynen
Intracavitary ultrasound phased arrays for prostate thermal therapies: MRI compatibility and in vivo testing.
Medical physics 1998;25(12):2392-9.
1998: NB Smith; Kullervo Hynynen
The feasibility of using focused ultrasound for transmyocardial revascularization.
Ultrasound in medicine & biology 1998;24(7):1045-54.
1998: Robert V Mulkern; Lawrence P Panych; N J McDannold; Ferenc A Jolesz; Kullervo Hynynen
Tissue temperature monitoring with multiple gradient-echo imaging sequences.
Journal of magnetic resonance imaging : JMRI 1998;8(2):493-502.
1998: Kullervo Hynynen; Ferenc A Jolesz
Demonstration of potential noninvasive ultrasound brain therapy through an intact skull.
Ultrasound in medicine & biology 1998;24(2):275-83.
1998: D R Daum; Kullervo Hynynen
Thermal dose optimization via temporal switching in ultrasound surgery.
IEEE transactions on ultrasonics, ferroelectrics, and frequency control 1998;45(1):208-15.
1998: K Kuroda; AH Chung; Kullervo Hynynen; Ferenc A Jolesz
Calibration of water proton chemical shift with temperature for noninvasive temperature imaging during focused ultrasound surgery.
Journal of magnetic resonance imaging : JMRI 1998;8(1):175-81.
1998: I A Mórocz; Kullervo Hynynen; H Gudbjartsson; Sharon Peled; V Colucci; F A Jólesz
Brain edema development after MRI-guided focused ultrasound treatment.
Journal of magnetic resonance imaging : JMRI 1998;8(1):136-42.
1998: E Hutchinson; M Dahleh; Kullervo Hynynen
The feasibility of MRI feedback control for intracavitary phased array hyperthermia treatments.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1998;14(1):39-56.
1997: T Fjield; V Sorrentino; H Cline; Kullervo Hynynen
Design and experimental verification of thin acoustic lenses for the coagulation of large tissue volumes.
Physics in medicine and biology 1997;42(12):2341-54.
1997: K Kuroda; Koichi Oshio; AH Chung; Kullervo Hynynen; Ferenc A Jolesz
Temperature mapping using the water proton chemical shift: a chemical shift selective phase mapping method.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1997;38(5):845-51.
1997: Kullervo Hynynen; Natalia Vykhodtseva; AH Chung; V Sorrentino; VM Colucci; Ferenc A Jolesz
Thermal effects of focused ultrasound on the brain: determination with MR imaging.
Radiology 1997;204(1):247-53.
1997: Kullervo Hynynen; J Dennie; J E Zimmer; W N Simmons; Ding Sheng He; Frank I Marcus; M Aguirre
Cylindrical ultrasonic transducers for cardiac catheter ablation.
IEEE transactions on bio-medical engineering 1997;44(2):144-51.
1996: A H Chung; Kullervo Hynynen; V Colucci; Koichi Oshio; H E Cline; Ferenc A Jolesz
Optimization of spoiled gradient-echo phase imaging for in vivo localization of a focused ultrasound beam.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;36(5):745-52.
1996: T Fjield; X Fan; Kullervo Hynynen
A parametric study of the concentric-ring transducer design for MRI guided ultrasound surgery.
The Journal of the Acoustical Society of America 1996;100(2 Pt 1):1220-30.
1996: E B Hutchinson; M T Buchanan; Kullervo Hynynen
Design and optimization of an aperiodic ultrasound phased array for intracavitary prostate thermal therapies.
Medical physics 1996;23(5):767-76.
1996: X Fan; Kullervo Hynynen
A study of various parameters of spherically curved phased arrays for noninvasive ultrasound surgery.
Physics in medicine and biology 1996;41(4):591-608.
1996: H E Cline; Kullervo Hynynen; E Schneider; Christopher J Hardy; S E Maier; Ronald Watkins; Ferenc A Jolesz
Simultaneous magnetic resonance phase and magnitude temperature maps in muscle.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1996;35(3):309-15.
1996: Kullervo Hynynen; W R Freund; H E Cline; A H Chung; Ronald Watkins; J P Vetro; Ferenc A Jolesz
A clinical, noninvasive, MR imaging-monitored ultrasound surgery method.
Radiographics : a review publication of the Radiological Society of North America, Inc 1996;16(1):185-95.
1996: Kullervo Hynynen; V Colucci; A Chung; Ferenc A Jolesz
Noninvasive arterial occlusion using MRI-guided focused ultrasound.
Ultrasound in medicine & biology 1996;22(8):1071-7.
1996: X Fan; Kullervo Hynynen
Ultrasound surgery using multiple sonications--treatment time considerations.
Ultrasound in medicine & biology 1996;22(4):471-82.
1996: Kullervo Hynynen; A H Chung; V Colucci; Ferenc A Jolesz
Potential adverse effects of high-intensity focused ultrasound exposure on blood vessels in vivo.
Ultrasound in medicine & biology 1996;22(2):193-201.
1995: J E Zimmer; Kullervo Hynynen; Ding Sheng He; F Marcus
The feasibility of using ultrasound for cardiac ablation.
IEEE transactions on bio-medical engineering 1995;42(9):891-7.
1995: Ding Sheng He; J E Zimmer; Kullervo Hynynen; Frank I Marcus; A C Caruso; L F Lampe; M L Aguirre
Application of ultrasound energy for intracardiac ablation of arrhythmias.
European heart journal 1995;16(7):961-6.
1995: D P Anhalt; Kullervo Hynynen; Robert B Roemer
Patterns of changes of tumour temperatures during clinical hyperthermia: implications for treatment planning, evaluation and control.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1995;11(3):425-36.
1995: Kullervo Hynynen; C A Damianou; V Colucci; E Unger; H H Cline; Ferenc A Jolesz
MR monitoring of focused ultrasonic surgery of renal cortex: experimental and simulation studies.
Journal of magnetic resonance imaging : JMRI 1995;5(3):259-66.
1995: H E Cline; Kullervo Hynynen; Ronald Watkins; W J Adams; J F Schenck; R H Ettinger; W R Freund; J P Vetro; Ferenc A Jolesz
Focused US system for MR imaging-guided tumor ablation.
Radiology 1995;194(3):731-7.
1995: X Fan; Kullervo Hynynen
Control of the necrosed tissue volume during noninvasive ultrasound surgery using a 16-element phased array.
Medical physics 1995;22(3):297-306.
1995: H Montes; Kullervo Hynynen
A system for the simultaneous delivery of intraoperative radiation and ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1995;11(1):109-19.
1995: N I Vykhodtseva; Kullervo Hynynen; C Damianou
Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo.
Ultrasound in medicine & biology 1995;21(7):969-79.
1994: M T Buchanan; Kullervo Hynynen
Design and experimental evaluation of an intracavitary ultrasound phased array system for hyperthermia.
IEEE transactions on bio-medical engineering 1994;41(12):1178-87.
1994: Kullervo Hynynen; A Darkazanli; C A Damianou; E Unger; J F Schenck
The usefulness of a contrast agent and gradient-recalled acquisition in a steady-state imaging sequence for magnetic resonance imaging-guided noninvasive ultrasound surgery.
Investigative radiology 1994;29(10):897-903.
1994: S J Tu; Kullervo Hynynen; Robert B Roemer
Simulation of bidirectional ultrasound hyperthermia treatments of neck tumours.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1994;10(5):707-22.
1994: H E Cline; Kullervo Hynynen; Christopher J Hardy; Ronald Watkins; J F Schenck; Ferenc A Jolesz
MR temperature mapping of focused ultrasound surgery.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1994;31(6):628-36.
1994: Ding Sheng He; J E Zimmer; Kullervo Hynynen; Frank I Marcus; A C Caruso; L F Lampe; M L Aguirre
Preliminary results using ultrasound energy for ablation of the ventricular myocardium in dogs.
The American journal of cardiology 1994;73(13):1029-31.
1994: C Damianou; Kullervo Hynynen
The effect of various physical parameters on the size and shape of necrosed tissue volume during ultrasound surgery.
The Journal of the Acoustical Society of America 1994;95(3):1641-9.
1994: X Fan; Kullervo Hynynen
The effects of curved tissue layers on the power deposition patterns of therapeutic ultrasound beams.
Medical physics 1994;21(1):25-34.
1994: N I Vykhodtseva; Kullervo Hynynen; C Damianou
Pulse duration and peak intensity during focused ultrasound surgery: theoretical and experimental effects in rabbit brain in vivo.
Ultrasound in medicine & biology 1994;20(9):987-1000.
1993: M K Croghan; D S Shimm; Kullervo Hynynen; D P Anhalt; S L Valencic; A M Fletcher; J M Kittleson; T C Cetas
A phase I study of the toxicity of regional hyperthermia with systemic warming.
American journal of clinical oncology 1993;16(4):354-8.
1993: H E Cline; J F Schenck; Ronald Watkins; Kullervo Hynynen; Ferenc A Jolesz
Magnetic resonance-guided thermal surgery.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 1993;30(1):98-106.
1993: Eduardo Moros; AW Dutton; Robert B Roemer; M Burton; Kullervo Hynynen
Experimental evaluation of two simple thermal models using hyperthermia in muscle in vivo.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1993;9(4):581-98.
1993: H Fosmire; Kullervo Hynynen; G W Drach; Baldassarre Stea; P Swift; J R Cassady
Feasibility and toxicity of transrectal ultrasound hyperthermia in the treatment of locally advanced adenocarcinoma of the prostate.
International journal of radiation oncology, biology, physics 1993;26(2):253-9.
1993: A Darkazanli; Kullervo Hynynen; Evan C Unger; J F Schenck
On-line monitoring of ultrasonic surgery with MR imaging.
Journal of magnetic resonance imaging : JMRI 1993;3(3):509-14.
1993: Kullervo Hynynen; K L Davis
Small cylindrical ultrasound sources for induction of hyperthermia via body cavities or interstitial implants.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1993;9(2):263-74.
1993: Kullervo Hynynen; A Darkazanli; C A Damianou; E Unger; J F Schenck
Tissue thermometry during ultrasound exposure.
European urology 1993;23 Suppl 1():12-6.
1993: Kullervo Hynynen; C Damianou; A Darkazanli; E Unger; J F Schenck
The feasibility of using MRI to monitor and guide noninvasive ultrasound surgery.
Ultrasound in medicine & biology 1993;19(1):91-2.
1993: Kullervo Hynynen
Acoustic power calibrations of cylindrical intracavitary ultrasound hyperthermia applicators.
Medical physics 1993;20(1):129-34.
1993: Kullervo Hynynen; A Darkazanli; E Unger; J F Schenck
MRI-guided noninvasive ultrasound surgery.
Medical physics 1993;20(1):107-15.
1993: C Damianou; Kullervo Hynynen
Focal spacing and near-field heating during pulsed high temperature ultrasound therapy.
Ultrasound in medicine & biology 1993;19(9):777-87.
1992: H E Cline; J F Schenck; Kullervo Hynynen; Ronald Watkins; S P Souza; Ferenc A Jolesz
MR-guided focused ultrasound surgery.
Journal of computer assisted tomography 1992;16(6):956-65.
1992: D Anhalt; Kullervo Hynynen
Thermocouples--the Arizona experience with in-house manufactured probes.
Medical physics 1992;19(5):1325-33.
1992: Kullervo Hynynen
The feasibility of interstitial ultrasound hyperthermia.
Medical physics 1992;19(4):979-87.
1992: X Fan; Kullervo Hynynen
The effect of wave reflection and refraction at soft tissue interfaces during ultrasound hyperthermia treatments.
The Journal of the Acoustical Society of America 1992;91(3):1727-36.
1992: Eduardo Moros; Kullervo Hynynen
A comparison of theoretical and experimental ultrasound field distributions in canine muscle tissue in vivo.
Ultrasound in medicine & biology 1992;18(1):81-95.
1992: W L Lin; Robert B Roemer; Eduardo Moros; Kullervo Hynynen
Optimization of temperature distributions in scanned, focused ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1992;8(1):61-78.
1992: L N Dorr; Kullervo Hynynen
The effects of tissue heterogeneities and large blood vessels on the thermal exposure induced by short high-power ultrasound pulses.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1992;8(1):45-59.
1991: Kullervo Hynynen
The role of nonlinear ultrasound propagation during hyperthermia treatments.
Medical physics 1991;18(6):1156-63.
1991: Paul M Harari; Kullervo Hynynen; Robert B Roemer; D P Anhalt; D S Shimm; Baldassarre Stea; J R Cassady
Development of scanned focussed ultrasound hyperthermia: clinical response evaluation.
International journal of radiation oncology, biology, physics 1991;21(3):831-40.
1991: A N Guthkelch; L P Carter; J R Cassady; Kullervo Hynynen; Robert Paul Iacono; P C Johnson; E A Obbens; Robert B Roemer; J F Seeger; D S Shimm
Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation: results of a phase I trial.
Journal of neuro-oncology 1991;10(3):271-84.
1991: Kullervo Hynynen
The threshold for thermally significant cavitation in dog's thigh muscle in vivo.
Ultrasound in medicine & biology 1991;17(2):157-69.
1990: Kullervo Hynynen
Hot spots created at skin-air interfaces during ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1990;6(6):1005-12.
1990: J Zaerr; Robert B Roemer; Kullervo Hynynen
Computer-controlled dynamic phantom for ultrasound hyperthermia studies.
IEEE transactions on bio-medical engineering 1990;37(11):1115-8.
1990: Kullervo Hynynen; D Shimm; D Anhalt; Baldassarre Stea; H Sykes; J R Cassady; Robert B Roemer
Temperature distributions during clinical scanned, focused ultrasound hyperthermia treatments.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1990;6(5):891-908.
1990: Chris J Diederich; Kullervo Hynynen
The development of intracavitary ultrasonic applicators for hyperthermia: a design and experimental study.
Medical physics 1990;17(4):626-34.
1990: Kullervo Hynynen; B A Lulu
Hyperthermia in cancer treatment.
Investigative radiology 1990;25(7):824-34.
1990: C Johnson; R Kress; R Roemer; Kullervo Hynynen
Multi-point feedback control system for scanned, focused ultrasound hyperthermia.
Physics in medicine and biology 1990;35(6):781-6.
1990: Eduardo Moros; Robert B Roemer; Kullervo Hynynen
Pre-focal plane high-temperature regions induced by scanning focused ultrasound beams.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1990;6(2):351-66.
1990: B E Billard; Kullervo Hynynen; Robert B Roemer
Effects of physical parameters on high temperature ultrasound hyperthermia.
Ultrasound in medicine & biology 1990;16(4):409-20.
1990: D Anhalt; Kullervo Hynynen; D DeYoung; D Shimm; M Kundrat; T Cetas
The CDRH Helix: an in vivo evaluation.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1990;6(1):241-52.
1989: Kullervo Hynynen; D DeYoung; M Kundrat; Eduardo Moros
The effect of blood perfusion rate on the temperature distributions induced by multiple, scanned and focused ultrasonic beams in dogs' kidneys in vivo.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1989;5(4):485-97.
1989: Kullervo Hynynen; D K Edwards
Temperature measurements during ultrasound hyperthermia.
Medical physics 1989;16(4):618-26.
1989: Chris J Diederich; Kullervo Hynynen
Induction of hyperthermia using an intracavitary multielement ultrasonic applicator.
IEEE transactions on bio-medical engineering 1989;36(4):432-8.
1989: D S Shimm; T C Cetas; Kullervo Hynynen; D N Buechler; D P Anhalt; H F Sykes; J R Cassady
The CDRH helix. A phase I clinical trial.
American journal of clinical oncology 1989;12(2):110-3.
1989: Kullervo Hynynen
Effect of tissue perfusion on temperature elevation.
Ultrasound in medicine & biology 1989;15 Suppl 1():41-3; discussion 45-6.
1988: D Anhalt; Kullervo Hynynen
The efficiency of clinical microwave applicators measured by a calorimetric method.
Medical physics 1988;15(6):919-21.
1988: D S Shimm; Kullervo Hynynen; D P Anhalt; Robert B Roemer; J R Cassady
Scanned focussed ultrasound hyperthermia: initial clinical results.
International journal of radiation oncology, biology, physics 1988;15(5):1203-8.
1988: Kullervo Hynynen; D DeYoung
Temperature elevation at muscle-bone interface during scanned, focused ultrasound hyperthermia.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1988;4(3):267-79.
1987: J Tobias; Kullervo Hynynen; R Roemer; A N Guthkelch; A S Fleischer; J Shively
An ultrasound window to perform scanned, focused ultrasound hyperthermia treatments of brain tumors.
Medical physics 1987;14(2):228-34.
1987: Kullervo Hynynen; R Roemer; D Anhalt; C Johnson; Z X Xu; W Swindell; T Cetas
A scanned, focused, multiple transducer ultrasonic system for localized hyperthermia treatments.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1987;3(1):21-35.