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Christine Iacobuzio-Donahue

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Tao Fu; Angela A Guzzetta; Craig M Hooker; Christine A Iacobuzio-Donahue; Jana Jeschke; Baohua Liu; Richard Morgan; Rajita Vatapalli; Pujan Dave; NITA AHUJA
KRAS G>A mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinoma.
Gang Zheng; Cristina Antonescu; Angelo M DeMarzo; Charles G Eberhart; Jonathan I Epstein; Edward Gabrielson; Christine A Iacobuzio-Donahue; PETER ILLEI; Tamara LEVIN Lotan; Anirban Maitra; Guido Martignoni; Elizabeth Montgomery; George Netto; Ie-Ming Shih; Janis M Taube; Michael Torbenson; William H Westra; T C Wu; Pedram Argani
A broad survey of cathepsin K immunoreactivity in human neoplasms.
Jin He; JOSEPH HERMAN; Ralph Hruban; Christine A Iacobuzio-Donahue; Timothy M Pawlik; Richard D Schulick; NITA AHUJA; John L Cameron; BARISH EDIL; Lei Zheng; Christopher L Wolfgang
Young patients undergoing resection of pancreatic cancer fare better than their older counterparts.

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2013: Tao Fu; Angela A Guzzetta; Craig M Hooker; Christine A Iacobuzio-Donahue; Jana Jeschke; Baohua Liu; Richard Morgan; Rajita Vatapalli; Pujan Dave; NITA AHUJA
KRAS G>A mutation favors poor tumor differentiation but may not be associated with prognosis in patients with curatively resected duodenal adenocarcinoma.
International journal of cancer. Journal international du cancer 2013;132(11):2502-9.
2013: Gang Zheng; Cristina Antonescu; Angelo M DeMarzo; Charles G Eberhart; Jonathan I Epstein; Edward Gabrielson; Christine A Iacobuzio-Donahue; PETER ILLEI; Tamara LEVIN Lotan; Anirban Maitra; Guido Martignoni; Elizabeth Montgomery; George Netto; Ie-Ming Shih; Janis M Taube; Michael Torbenson; William H Westra; T C Wu; Pedram Argani
A broad survey of cathepsin K immunoreactivity in human neoplasms.
American journal of clinical pathology 2013;139(2):151-9.
2013: Jin He; JOSEPH HERMAN; Ralph Hruban; Christine A Iacobuzio-Donahue; Timothy M Pawlik; Richard D Schulick; NITA AHUJA; John L Cameron; BARISH EDIL; Lei Zheng; Christopher L Wolfgang
Young patients undergoing resection of pancreatic cancer fare better than their older counterparts.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2013;17(2):339-44.
2013: Alvin Makohon-Moore; Christine A Iacobuzio-Donahue
Considerations for sequencing analyses of pancreatic cancer progression and metastasis.
Methods in molecular biology (Clifton, N.J.) 2013;980():121-9.
2013: Anne M Macgregor-Das; Christine A Iacobuzio-Donahue
Molecular pathways in pancreatic carcinogenesis.
Journal of surgical oncology 2013;107(1):8-14.
2012: Yunfeng Cui; Luis Alberto Diaz; Amanda L Blackford; Jacqueline A Brosnan; Ralph Hruban; Christine A Iacobuzio-Donahue; Kenneth W Kinzler; Anirban Maitra; Surojit Sur; Bert Vogelstein; James R Eshleman
Genetically defined subsets of human pancreatic cancer show unique in vitro chemosensitivity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(23):6519-30.
2012: Christopher H Crane; Christine A Iacobuzio-Donahue
Keys to personalized care in pancreatic oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(33):4049-50.
2012: Andrew V Biankin; Andrew Brown; F Charles Brunicardi; Tim Bruxner; Nicholas Buchner; Christian J Buhay; Paola Capelli; David K Chang; Kyle Chang; Lorraine A Chantrill; Venessa T Chin; Angela Chou; Angelika Christ; Nicole Cloonan; Emily K Colvin; Neal G Copeland; Vincenzo Corbo; Mark J Cowley; Roger J Daly; Richard De Borja; Robert E Denroche; Huyen Dinh; Jennifer Drummond; Krishna Epari; James R Eshleman; J Lynn Fink; William E Fisher; Steven Gallinger; Brooke B Gardiner; Richard A Gibbs; Anthony J Gill; Marie-Claude Gingras; Milena Gongora; David J Adams; Matthew Anderson; Andrew Barbour; Timothy Beck; Kimberly Begley; Yi Han; Ivon Harliwong; Sally E Hodges; Oliver Holmes; Ralph Hruban; Thomas J Hudson; Emily S Humphrey; Jeremy L Humphris; Christine A Iacobuzio-Donahue; Senel Idrisoglu; Nancy A Jenkins; Amber L Johns; Marc D Jones; Nipun Kakkar; Warren Kaplan; Karin S Kassahn; James G Kench; Gabriel Kolle; David A Largaespada; Rita T Lawlor; Conrad Leonard; Lora R Lewis; Jessica A Lovell; Anirban Maitra; Karen M Mann; Suzanne Manning; Amanda Mawson; John D McPherson; R Scott Mead; Neil D Merrett; David K Miller; Richard A Morgan; Debabrata Mukhopadhyay; Elizabeth A Musgrove; Lakshmi B Muthuswamy; Donna M Muzny; Adnan M Nagrial; Felicity Newell; Nam Q Nguyen; Katia Nones; Ehsan Nourbakhsh; Craig Nourse; Nicole Onetto; Deepa Pai; Marina Pajic; Ami Panchal; Ann-Marie Patch; John V Pearson; Pedro A Perez-Mancera; Gloria M Petersen; Mark Pinese; Andreia V Pinho; Jeffrey G Reid; Ilse Rooman; Alistair G Rust; Michelle Sam; Jaswinder S Samra; Maria Scardoni; Christopher J Scarlett; Aldo Scarpa; Richard D Schulick; Stefano Serra; Patricia A Shaw; Sarah Song; Lincoln D Stein; Robert L Sutherland; Darrin Taylor; Margaret A Tempero; Lee Timms; Christopher Toon; Giampaolo Tortora; Ming-Sound Tsao; David A Tuveson; Nicola Waddell; Min Wang; Shivangi Wani; Lodewyk F A Wessels; David A Wheeler; Peter J Wilson; Christopher L Wolfgang; Scott Wood; Jianmin Wu; Yuan Qing Wu; Qinying Xu; Christina K Yung; Nikolajs Zeps; Fengmei Zhao; Sean M Grimmond
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
Nature 2012;491(7424):399-405.
2012: Shinichi Yachida; Yi Zhong; Jacqueline A Brosnan; JOSEPH HERMAN; Ralph Hruban; Siân Jones; Alison P Klein; Daniel Laheru; Anne M Macgregor-Das; Richard A Morgan; Yoshiki Naito; Tyler Saunders; Victor E Velculescu; Catherine M White; Christopher L Wolfgang; Christine A Iacobuzio-Donahue
Clinical significance of the genetic landscape of pancreatic cancer and implications for identification of potential long-term survivors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(22):6339-47.
2012: Min-Sik Kim; Sarada V Kuppireddy; Anirban Maitra; Sruthi Sakamuri; Mukul Singal; Shantal G Tankala; Victor E Velculescu; Lavanya Balakrishnan; Derese Getnet; Renu Goel; Michael Goggins; H C Harsha; Ralph Hruban; Christine A Iacobuzio-Donahue; Harrys K C Jacob; Elizabeth M Jaffee; Manoj K Kashyap; Akhilesh Pandey
Rapid characterization of candidate biomarkers for pancreatic cancer using cell microarrays (CMAs).
Journal of proteome research 2012;11(11):5556-63.
2012: Safia N Salaria; Mirte M Streppel; Christine A Iacobuzio-Donahue; Linda A Lee; Elizabeth Montgomery
Sessile serrated adenomas: high-risk lesions?
Human pathology 2012;43(11):1808-14.
2012: BAOJIN FU; Elizabeth Montgomery; Richard Morgan; Shinichi Yachida; Yi Zhong; Christine A Iacobuzio-Donahue
Clinicopathologic and genetic characterization of traditional serrated adenomas of the colon.
American journal of clinical pathology 2012;138(3):356-66.
2012: Tao Fu; Angela A Guzzetta; Craig M Hooker; Christine A Iacobuzio-Donahue; Jana Jeschke; Ruby Kwak; Richard Morgan; Emmanouil P Pappou; Christopher L Wolfgang; Stephen B Baylin; Pujan Dave; NITA AHUJA
CpG island methylator phenotype-positive tumors in the absence of MLH1 methylation constitute a distinct subset of duodenal adenocarcinomas and are associated with poor prognosis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(17):4743-52.
2012: Christine A Iacobuzio-Donahue
Personalized medicine in pancreatic cancer: prognosis and potential implications for therapy.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2012;16(9):1651-2.
2012: Christine A Iacobuzio-Donahue; Victor E Velculescu; Christopher L Wolfgang; Ralph Hruban
Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(16):4257-65.
2012: Elizabeth C Wick; Christine A Iacobuzio-Donahue; Robert E LeBlanc; Guillermo Ortega; Drew M Pardoll; Elizabeth A Platz; Chelsea Robinson; Cynthia L Sears
Shift from pStat6 to pStat3 predominance is associated with inflammatory bowel disease-associated dysplasia.
Inflammatory bowel diseases 2012;18(7):1267-74.
2012: Christine A Iacobuzio-Donahue
Genetic evolution of pancreatic cancer: lessons learnt from the pancreatic cancer genome sequencing project.
Gut 2012;61(7):1085-94.
2012: Pedro A Pérez-Mancera; Christian Pilarsky; Petra Rümmele; Alistair G Rust; Aaron L Sarver; Kevin A T Silverstein; Shane Stegeman; Derek L Stemple; Jelle J ten Hoeve; Louise van der Weyden; Lodewyk F A Wessels; Stephen A Wood; Jun Yu; David J Adams; Daniela Aust; Andrew V Biankin; Jacqueline A Brosnan; David K Chang; Lara S Collier; Jeroen de Ridder; Michael Goggins; Sean M Grimmond; Robert Grützmann; Colin Herd; Ralph Hruban; Christine A Iacobuzio-Donahue; Ross Kettleborough; Alison P Klein; Spencer Knight; Thomas Knösel; Glen Kristiansen; David A Largaespada; Allen Li; Ang Li; Richard Morgan; David A Tuveson
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma.
Nature 2012;486(7402):266-70.
2012: Jacqueline A Brosnan; Christine A Iacobuzio-Donahue
A new branch on the tree: next-generation sequencing in the study of cancer evolution.
Seminars in cell & developmental biology 2012;23(2):237-42.
2012: Joo-Mi Yi; Mashaal Dhir; Angela A Guzzetta; Kyu Heo; Christine A Iacobuzio-Donahue; Hwan Mook Kim; Hiromu Suzuki; Minoru Toyota; Kwang Mo Yang; NITA AHUJA
DNA methylation biomarker candidates for early detection of colon cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012;33(2):363-72.
2012: Peter Duesberg; Christine A Iacobuzio-Donahue; Daniele Mandrioli; Amanda McCormack; Jacqueline A Brosnan; Lewis Chen
Origin of metastases: subspecies of cancers generated by intrinsic karyotypic variations.
Cell cycle (Georgetown, Tex.) 2012;11(6):1151-66.
2012: Shinichi Yachida; Yi Zhong; Roeland F de Wilde; Angelo M DeMarzo; BARISH EDIL; Jessica Hicks; Ralph Hruban; David S Klimstra; Daniel Laheru; Anirban Maitra; Richard Morgan; Tyler Saunders; Richard D Schulick; Rajni Sharma; Chanjuan Shi; Laura H Tang; Efsevia Vakiani; Catherine M White; Christopher L Wolfgang; Christine A Iacobuzio-Donahue
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors.
The American journal of surgical pathology 2012;36(2):173-84.
2012: Hiroshi Haeno; JOSEPH HERMAN; Christine A Iacobuzio-Donahue; Meghan B Davis; Mithat Gonen; Franziska Michor
Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies.
Cell 2012;148(1-2):362-75.
2012: Tara Holley; Christine A Iacobuzio-Donahue; Christophe Legendre; Elizabeth Lenkiewicz; Ann E McCullough; Barbara Pockaj; Cyrill A Rentsch; Christian Ruiz; Mark Stapleton; Waibhav Tembe; Daniel Von Hoff; Lukas Bubendorf; John D Carpten; David Craig; Heather E Cunliffe; Lisa Evers; Joel R Gsponer; Doug Amorese; Michael T Barrett
Deep clonal profiling of formalin fixed paraffin embedded clinical samples.
PloS one 2012;7(11):e50586.
2012: Amy Belton; Alexander Gabrovsky; David L Huso; Christine A Iacobuzio-Donahue; Ray Reeves; Young Kyung Bae; Linda M. Resar
HMGA1 induces intestinal polyposis in transgenic mice and drives tumor progression and stem cell properties in colon cancer cells.
PloS one 2012;7(1):e30034.
2012: Siân Jones; Xiaosong Zhang; Hai Yan; James R Eshleman; Petra Kristel; Bert Vogelstein; Michael Goggins; Steve Powell; Jelle Wesseling; Marjanka K Schmidt; Anirban Maitra; DONALD PARSONS; Sami Malek; Christine A Iacobuzio-Donahue; Darell Bigner; Ralph Hruban; Meng Li; Sanford Markowitz; Kenneth W Kinzler; Victor E Velculescu; Nickolas Papadopoulos
Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types.
Human mutation 2012;33(1):100-3.
2011: Laurent Dumartin; Deepak Hariharan; Teresa A Brentnall; Hannah J Whiteman; Mary P Bronner; Caroline Brennan; Branko Dmitrovic; Christine A Iacobuzio-Donahue; Roger M Feakins; Nicholas R Lemoine; John F Timms; Mark E Weeks; Tatjana Crnogorac-Jurcevic
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.
Cancer research 2011;71(22):7091-102.
2011: Wanglong Qiu; Andrew M Lowy; Chia-Yu Kuo; Christine A Iacobuzio-Donahue; Dan E Arking; Helen E Remotti; Fikret Sahin; Wendy M Wang; Ralph Hruban; Dario Garcia-Carracedo; Doris Chen; Gloria H Su
Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo.
Oncotarget 2011;2(11):862-73.
2011: Mashaal Dhir; Sabine C Glöckner; James G Herman; Christine A Iacobuzio-Donahue; Jana Jeschke; Elizabeth Montgomery; Emmanouil P Pappou; Shinichi Yachida; Leander Van Neste; Stephen B Baylin; NITA AHUJA
Sessile serrated adenomas and classical adenomas: an epigenetic perspective on premalignant neoplastic lesions of the gastrointestinal tract.
International journal of cancer. Journal international du cancer 2011;129(8):1889-98.
2011: Christopher M Heaphy; Seung-Mo Hong; Christine A Iacobuzio-Donahue; Robert J Kurman; QING KAY LI; Tamara LEVIN Lotan; Anirban Maitra; Elizabeth Montgomery; GEORGES NETTO; Dinesh Rakheja; Richard B S Roden; Ie-Ming Shih; Andrea P Subhawong; Janis M Taube; Luigi Terracciano; Michael Torbenson; William H Westra; Tzyy-choou Wu; Pedram Argani; Angelo M DeMarzo; Charles G Eberhart; Jonathan I Epstein; Edward Gabrielson; Michael Goggins; Alan K Meeker
Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes.
The American journal of pathology 2011;179(4):1608-15.
2011: George J Arnaoutakis; John L Cameron; BARISH EDIL; JOSEPH HERMAN; Ralph Hruban; Christine A Iacobuzio-Donahue; Daniel Laheru; Avedis Meneshian; Timothy M Pawlik; Deepa Rangachari; Richard D Schulick; Stephen C Yang; Christopher L Wolfgang
Pulmonary resection for isolated pancreatic adenocarcinoma metastasis: an analysis of outcomes and survival.
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2011;15(9):1611-7.
2011: Seung-Mo Hong; Ralph Hruban; Christine A Iacobuzio-Donahue; Ang Li; Kelly Olino; Richard D Schulick; Christopher L Wolfgang; JOSEPH HERMAN; Michael Goggins
Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2011;24(9):1237-47.
2011: Michael C Haffner; Christine A Iacobuzio-Donahue; Alan K Meeker; William G Nelson; GEORGES NETTO; Laxmi G Pellakuru; Antoun Toubaji; Pedram Argani; Alcides Chaux; Angelo M DeMarzo; David M Esopi; Jonathan Michael Gerber; Srinivasan Yegnasubramanian
Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.
Oncotarget 2011;2(8):627-37.
2011: Shinichi Yachida; Yi Zhong; Daniel Laheru; Laura A Morsberger; Raul Patrascu; Meghan B Davis; Constance A Griffin; Ralph Hruban; Christine A Iacobuzio-Donahue
Establishment and characterization of a new cell line, A99, from a primary small cell carcinoma of the pancreas.
Pancreas 2011;40(6):905-10.
2011: Gina M DeNicola; Kristopher Frese; Aarthi Gopinathan; Ralph Hruban; Timothy J Humpton; Christine A Iacobuzio-Donahue; Florian A Karreth; Scott E Kern; Dipti Mangal; Francesca Scrimieri; Cong Wei; Jordan M Winter; Charles J Yeo; Kenneth H Yu; Ian Blair; Eric S Calhoun; David A Tuveson
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.
Nature 2011;475(7354):106-9.
2011: Willem Arnout van Hattem; Danielle Langeveld; Wendy W J De Leng; Folkert H Morsink; Paulus van Diest; Christine A Iacobuzio-Donahue; Francis M Giardiello; G Johan A Offerhaus; Lodewijk A A Brosens
Histologic variations in juvenile polyp phenotype correlate with genetic defect underlying juvenile polyposis.
The American journal of surgical pathology 2011;35(4):530-6.
2011: Joo-Mi Yi; Mashaal Dhir; Leander Van Neste; Stephanie R Downing; Jana Jeschke; Sabine C Glöckner; Marilia de Freitas Calmon; Craig M Hooker; Juan M Funes; Chris Boshoff; Kim M Smits; Manon van Engeland; Matty P Weijenberg; Christine A Iacobuzio-Donahue; James G Herman; Kornel E Schuebel; Stephen B Baylin; NITA AHUJA
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(6):1535-45.
2011: Philip J Stephens; Chris D Greenman; Beiyuan Fu; Fengtang Yang; Graham R Bignell; Laura J Mudie; Erin D Pleasance; King Wai Lau; David Beare; Lucy A Stebbings; Stuart McLaren; Meng-Lay Lin; David J McBride; Ignacio Varela; Serena Nik-Zainal; Catherine Leroy; Mingming Jia; Andrew Menzies; Adam P Butler; Jon W Teague; Michael A Quail; John Burton; Harold Swerdlow; Nigel P Carter; Laura A Morsberger; Christine A Iacobuzio-Donahue; George A Follows; Anthony R Green; Adrienne M Flanagan; Michael R Stratton; P Andrew Futreal; Peter J Campbell
Massive genomic rearrangement acquired in a single catastrophic event during cancer development.
Cell 2011;144(1):27-40.
2011: Yi Zhong; Emilia Albesiano; Christopher Cummings; Mousumi Dhara; BAOJIN FU; Constance A Griffin; Ang Li; Li Li; Qingyong Ma; Paola Martinelli; Yoshiki Naito; Fan Pan; Francisco X Real; Felip Vilardell; Zheng Wang; Shinichi Yachida; Raluca Yonescu; Christine A Iacobuzio-Donahue
GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1.
PloS one 2011;6(7):e22129.
2010: Wells A Messersmith; Antonio Jimeno; Heather A Jacene; Ming Zhao; Piotr Kulesza; Daniel Laheru; Yasmin Kahn; Alexander Spira; Janet Dancey; Christine A Iacobuzio-Donahue; Ross C Donehower; Michael A Carducci; MICHELLE RUDEK-RENAUT; Manuel Hidalgo
Phase I trial of oxaliplatin, infusional 5-fluorouracil, and leucovorin (FOLFOX4) with erlotinib and bevacizumab in colorectal cancer.
Clinical colorectal cancer 2010;9(5):297-304.
2010: Shinichi Yachida; Siân Jones; Ivana Bozic; Tibor Antal; Rebecca Leary; BAOJIN FU; Mihoko Kamiyama; Ralph Hruban; James R Eshleman; Martin A Nowak; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Christine A Iacobuzio-Donahue
Distant metastasis occurs late during the genetic evolution of pancreatic cancer.
Nature 2010;467(7319):1114-7.
2010: Peter J Campbell; Shinichi Yachida; Laura J Mudie; Philip J Stephens; Erin D Pleasance; Lucy A Stebbings; Laura A Morsberger; Calli Latimer; Stuart McLaren; Meng-Lay Lin; David J McBride; Ignacio Varela; Serena A Nik-Zainal; Catherine Leroy; Mingming Jia; Andrew Menzies; Adam P Butler; Jon Teague; Constance A Griffin; John Burton; Harold Swerdlow; Michael A Quail; Michael R Stratton; Christine A Iacobuzio-Donahue; P Andrew Futreal
The patterns and dynamics of genomic instability in metastatic pancreatic cancer.
Nature 2010;467(7319):1109-13.
2010: I Garrido-Laguna; Aik Choon Tan; M Uson; M Angenendt; Wen W Ma; M C Villaroel; Ming Zhao; RAJESH KUMAR NV; Antonio Jimeno; Ross C Donehower; Christine A Iacobuzio-Donahue; M Barrett; MICHELLE RUDEK-RENAUT; Belen Rubio-Viqueira; Daniel Laheru; Manuel Hidalgo
Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.
British journal of cancer 2010;103(5):649-55.
2010: Jeran K Stratford; David J Bentrem; Judy M Anderson; Cheng Fan; Keith A Volmar; J S Marron; Elizabeth D Routh; Laura S Caskey; Jonathan C Samuel; Channing J Der; Leigh B Thorne; Benjamin F Calvo; Hong Jin Kim; Mark S Talamonti; Christine A Iacobuzio-Donahue; Michael A Hollingsworth; Charles M Perou; Jen Jen Yeh
A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma.
PLoS medicine 2010;7(7):e1000307.
2010: Yiping He; Jian Wu; Devin C Dressman; Christine A Iacobuzio-Donahue; Sanford D Markowitz; Victor E Velculescu; Luis Alberto Diaz; Kenneth W Kinzler; Bert Vogelstein; Nickolas Papadopoulos
Heteroplasmic mitochondrial DNA mutations in normal and tumour cells.
Nature 2010;464(7288):610-4.
2010: Zeshaan A Rasheed; Jie Yang; Qiuju Wang; Jeanne Kowalski; Irwin Freed; Christopher Murter; Seung-Mo Hong; Jan-Bart Koorstra; RAJESH KUMAR NV; Xiaobing He; Michael Goggins; Christine A Iacobuzio-Donahue; berman david; Daniel Laheru; Antonio Jimeno; Manuel Hidalgo; Anirban Maitra; William Matsui
Prognostic significance of tumorigenic cells with mesenchymal features in pancreatic adenocarcinoma.
Journal of the National Cancer Institute 2010;102(5):340-51.
2010: George A. Poultsides; Sushanth Reddy; John L Cameron; Ralph Hruban; Timothy M Pawlik; NITA AHUJA; Ajay Jain; BARISH EDIL; Christine A Iacobuzio-Donahue; Richard D Schulick; Christopher L Wolfgang
Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas.
Annals of surgery 2010;251(3):470-6.
2010: Robert B Scharpf; Christine A Iacobuzio-Donahue; Leslie Cope; Ingo Ruczinski; Elizabeth Garrett-Mayer; Sindhu Lakkur; Domenico Campagna; Giovanni Parmigiani
Cross-platform Comparison of Two Pancreatic Cancer Phenotypes.
Cancer informatics 2010;9():257-64.
2010: Felip Vilardell; Christine A Iacobuzio-Donahue
Cancer gene profiling in pancreatic cancer.
Methods in molecular biology (Clifton, N.J.) 2010;576():279-92.
2010: Alexandra C Hristov; Leslie Cope; Francescopaolo Di Cello; Marcelo Delos Reyes; Mansher Singh; Joelle Anne Hillion; Amy Belton; Biju Joseph; Andrew Schuldenfrei; Christine A Iacobuzio-Donahue; Anirban Maitra; Linda M. Resar
HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010;23(1):98-104.
2009: Shinichi Yachida; Shiyama Mudali; Sherri A Martin; Elizabeth Montgomery; Christine A Iacobuzio-Donahue
Beta-catenin nuclear labeling is a common feature of sessile serrated adenomas and correlates with early neoplastic progression after BRAF activation.
The American journal of surgical pathology 2009;33(12):1823-32.
2009: Kiyoshi Yoshimura; Kristen F Meckel; Lindsay S Laird; Christina Y Chia; Jang-June Park; Kelly L Olino; Ryouichi Tsunedomi; Toshio Harada; Norio Iizuka; Shoichi Hazama; Yukihiko Kato; Jesse W Keller; John M Thompson; Fumin Chang; Lewis H Romer; Ajay Jain; Christine A Iacobuzio-Donahue; Masaaki Oka; Drew M Pardoll; Richard D Schulick
Integrin alpha2 mediates selective metastasis to the liver.
Cancer research 2009;69(18):7320-8.
2009: Amanda Blackford; Oscar K Serrano; Christopher L Wolfgang; Giovanni Parmigiani; Siân Jones; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Rebecca J Leary; James R Eshleman; Michael Goggins; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; John L Cameron; Kelly Olino; Richard D Schulick; Jordan Winter; JOSEPH HERMAN; Daniel Laheru; Alison P Klein; Bert Vogelstein; Kenneth W Kinzler; Victor E Velculescu; Ralph Hruban
SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(14):4674-9.
2009: Kenneth P Olive; Michael Jacobetz; Christian J Davidson; Aarthi Gopinathan; Dominick McIntyre; Davina Honess; Basetti Madhu; Mae A Goldgraben; Meredith E Caldwell; David Allard; Kristopher K Frese; Gina Denicola; Christine Feig; Chelsea Combs; Stephen P Winter; Heather Ireland-Zecchini; Stefanie Reichelt; William J Howat; ALEX CHANG; Mousumi Dhara; Lifu Wang; Felix Rückert; Robert Grützmann; Christian Pilarsky; Kamel Izeradjene; Sunil R Hingorani; Pearl Huang; Susan E Davies; William Plunkett; Merrill Egorin; Ralph Hruban; Nigel Whitebread; Karen McGovern; Julian Adams; Christine A Iacobuzio-Donahue; John Griffiths; David A Tuveson
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.
Science (New York, N.Y.) 2009;324(5933):1457-61.
2009: Sabine C Glöckner; Mashaal Dhir; Joo-Mi Yi; Kelly E McGarvey; Leander Van Neste; joost louwagie; Timothy Chan; Wolfram Kleeberger; Adriaan P de Bruïne; Kim M Smits; Carolina A J Khalid-de Bakker; Daisy M A E Jonkers; Reinhold W Stockbrügger; Gerrit A Meijer; Frank A Oort; Christine A Iacobuzio-Donahue; Katja Bierau; James G Herman; Stephen B Baylin; Manon Van Engeland; Kornel E Schuebel; NITA AHUJA
Methylation of TFPI2 in stool DNA: a potential novel biomarker for the detection of colorectal cancer.
Cancer research 2009;69(11):4691-9.
2009: Amanda Blackford; Giovanni Parmigiani; Thomas W Kensler; Christopher L Wolfgang; Siân Jones; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Rebecca J Leary; James R Eshleman; Michael Goggins; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; Alison P Klein; John L Cameron; Kelly Olino; Richard D Schulick; Jordan Winter; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler; Ralph Hruban
Genetic mutations associated with cigarette smoking in pancreatic cancer.
Cancer research 2009;69(8):3681-8.
2009: Christine A Iacobuzio-Donahue; BAOJIN FU; Shinichi Yachida; Mingde Luo; Hisashi Abe; Clark M Henderson; Felip Vilardell; Zheng Wang; Jesse W Keller; Priya Banerjee; JOSEPH HERMAN; John L Cameron; Charles J Yeo; Marc K Halushka; James R Eshleman; Marian Raben; Alison P Klein; Ralph Hruban; Manuel Hidalgo; Daniel Laheru
DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(11):1806-13.
2009: Siân Jones; Ralph Hruban; Mihoko Kamiyama; Michael Borges; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Emily Palmisano; Kieran Brune; Elizabeth M Jaffee; Christine A Iacobuzio-Donahue; Anirban Maitra; Giovanni Parmigiani; Scott E Kern; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; James R Eshleman; Michael Goggins; Alison P Klein
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.
Science (New York, N.Y.) 2009;324(5924):217.
2009: Shinichi Yachida; Christine A Iacobuzio-Donahue
The pathology and genetics of metastatic pancreatic cancer.
Archives of pathology & laboratory medicine 2009;133(3):413-22.
2009: Sean Sullivan; Philip Alex; Themistocles Dassopoulos; Nicholas Constantine Zachos; Christine A Iacobuzio-Donahue; Mark Donowitz; Steven R Brant; C Cuffari; Mary L Harris; Lisa Datta; Laurie Conklin; Yueping Chen; Xuhang Li
Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea.
Inflammatory bowel diseases 2009;15(2):261-74.
2009: Matthew S Karafin; Christopher T Cummings; BAOJIN FU; Christine A Iacobuzio-Donahue
The developmental transcription factor Gata4 is overexpressed in pancreatic ductal adenocarcinoma.
International journal of clinical and experimental pathology 2009;3(1):47-55.
2009: Jonathan D Samet; Karen M Horton; elliot fishman; Christine A Iacobuzio-Donahue
Cronkhite-Canada Syndrome: Gastric Involvement Diagnosed by MDCT.
Case reports in medicine 2009;2009():148795.
2009: W Arnout van Hattem; Lodewijk A A Brosens; Susan Y Marks; Anya N A Milne; Susanne van Eeden; Christine A Iacobuzio-Donahue; Ari Ristimäki; Francis M Giardiello; G Johan A Offerhaus
Increased cyclooxygenase-2 expression in juvenile polyposis syndrome.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2009;7(1):93-7.
2009: Alexandra C Hristov; Leslie Cope; Marcelo Delos Reyes; Mansher Singh; Christine A Iacobuzio-Donahue; Anirban Maitra; Linda M. Resar
HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(1):43-9.
2009: Christine A Iacobuzio-Donahue
Epigenetic changes in cancer.
Annual review of pathology 2009;4():229-49.
2008: Vishal S Chandan; Christine A Iacobuzio-Donahue; Susan C Abraham
Patchy distribution of pathologic abnormalities in autoimmune pancreatitis: implications for preoperative diagnosis.
The American journal of surgical pathology 2008;32(12):1762-9.
2008: Shuaili Chen; Theresa Auletta; Ostap Dovirak; Christina Hutter; Karen Kuntz; Samira El-ftesi; Jude Kendall; Haiyong Han; Daniel Von Hoff; Raheela Ashfaq; Anirban Maitra; Christine A Iacobuzio-Donahue; Ralph Hruban; Robert Lucito
Copy number alterations in pancreatic cancer identify recurrent PAK4 amplification.
Cancer biology & therapy 2008;7(11):1793-802.
2008: BAOJIN FU; Mingde Luo; Sindhu Lakkur; Robert Lucito; Christine A Iacobuzio-Donahue
Frequent genomic copy number gain and overexpression of GATA-6 in pancreatic carcinoma.
Cancer biology & therapy 2008;7(10):1593-601.
2008: Siân Jones; Xiaosong Zhang; DONALD PARSONS; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; Hirohiko Kamiyama; Antonio Jimeno; Seung-Mo Hong; BAOJIN FU; Ming-Tseh Lin; Eric S Calhoun; Mihoko Kamiyama; Kimberly Walter; Tatiana Nikolskaya; Yuri Nikolsky; James Hartigan; Douglas R Smith; Manuel Hidalgo; Steven D Leach; Alison P Klein; Elizabeth M Jaffee; Michael Goggins; Anirban Maitra; Christine A Iacobuzio-Donahue; James R Eshleman; Scott E Kern; Ralph Hruban; Rachel Karchin; Nickolas Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Science (New York, N.Y.) 2008;321(5897):1801-6.
2008: Cheryl J Pendergrass; daniel edelstein; Linda M Hylind; Blaine T Phillips; Christine A Iacobuzio-Donahue; Katharine E Romans; Constance A Griffin; Marcia Cruz-Correa; Anne C Tersmette; G Johan A Offerhaus; Francis M Giardiello
Occurrence of colorectal adenomas in younger adults: an epidemiologic necropsy study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2008;6(9):1011-5.
2008: Antonio Jimeno; Aik Choon Tan; Jordy Coffa; RAJESH KUMAR NV; Piotr Kulesza; Belen Rubio-Viqueira; Jenna Wheelhouse; Begoña Diosdado; Wells A Messersmith; Christine A Iacobuzio-Donahue; Anirban Maitra; Marileila Varella-Garcia; Fred R Hirsch; Gerrit A Meijer; Manuel Hidalgo
Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer.
Cancer research 2008;68(8):2841-9.
2008: Julie M Wu; Elizabeth Montgomery; Christine A Iacobuzio-Donahue
Frequent beta-catenin nuclear labeling in sessile serrated polyps of the colorectum with neoplastic potential.
American journal of clinical pathology 2008;129(3):416-23.
2008: Lodewijk A A Brosens; Josbert J Keller; Leena Pohjola; Caj Haglund; Folkert H Morsink; Christine A Iacobuzio-Donahue; Michael Goggins; Francis M Giardiello; Ari Ristimäki; G Johan A Offerhaus
Increased expression of cytoplasmic HuR in familial adenomatous polyposis.
Cancer biology & therapy 2008;7(3):424-7.
2008: Jordan M Winter; Angela H Ting; Felip Vilardell; Eike Gallmeier; Stephen B Baylin; Ralph Hruban; Scott E Kern; Christine A Iacobuzio-Donahue
Absence of E-cadherin expression distinguishes noncohesive from cohesive pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(2):412-8.
2008: Dengfeng Cao; Kornelia Polyak; Marc K Halushka; HIND NASSAR; Nina Kouprina; Christine A Iacobuzio-Donahue; Xinyan Wu; Saraswati Sukumar; Jessica Hicks; Angelo M DeMarzo; Pedram Argani
Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.
Breast cancer research : BCR 2008;10(5):R91.
2008: Dengfeng Cao; Raheela Ashfaq; Michael Goggins; Ralph Hruban; Scott E Kern; Christine A Iacobuzio-Donahue
Differential expression of multiple genes in association with MADH4/DPC4/SMAD4 inactivation in pancreatic cancer.
International journal of clinical and experimental pathology 2008;1(6):510-7.
2008: Domenico Campagna; Leslie Cope; Sindhu S Lakkur; Clark Henderson; Daniel Laheru; Christine A Iacobuzio-Donahue
Gene expression profiles associated with advanced pancreatic cancer.
International journal of clinical and experimental pathology 2008;1(1):32-43.
2007: Atsushi Kaneda; Chiaochun J Wang; Raymond Cheong; Winston Timp; Patrick Onyango; Bo Wen; Christine A Iacobuzio-Donahue; Rolf Ohlsson; Rita Andraos; Mark A Pearson; Alexei A Sharov; Dan Longo; Minoru S H Ko; Andre Levchenko; Andrew P Feinberg
Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(52):20926-31.
2007: Wendy W J De Leng; Marnix Jansen; Ralph Carvalho; M Polak; Alex R Musler; Anya N A Milne; Josbert J Keller; Fred H Menko; Felix W M de Rooij; Christine A Iacobuzio-Donahue; Francis M Giardiello; Marian A J Weterman; G Johan A Offerhaus
Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates.
Clinical genetics 2007;72(6):568-73.
2007: BAOJIN FU; Mingzhou Guo; Shelun Wang; Domenico Campagna; Mingde Luo; James G Herman; Christine A Iacobuzio-Donahue
Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types.
Cancer biology & therapy 2007;6(10):1546-52.
2007: Tomas Hucl; Jonathan R Brody; Eike Gallmeier; Christine A Iacobuzio-Donahue; Iain K G Farrance; Scott E Kern
High cancer-specific expression of mesothelin (MSLN) is attributable to an upstream enhancer containing a transcription enhancer factor dependent MCAT motif.
Cancer research 2007;67(19):9055-65.
2007: Wendy W J De Leng; Marnix Jansen; Josbert J Keller; M de Gijsel; Anya N A Milne; F H M Morsink; Marian A J Weterman; Christine A Iacobuzio-Donahue; H C Clevers; Francis M Giardiello; G Johan A Offerhaus
Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment.
Gut 2007;56(10):1475-6.
2007: Robert B Scharpf; Christine A Iacobuzio-Donahue; Julie B Sneddon; Giovanni Parmigiani
When should one subtract background fluorescence in 2-color microarrays?
Biostatistics (Oxford, England) 2007;8(4):695-707.
2007: Lodewijk A A Brosens; Arnout van Hattem; Linda M Hylind; Christine A Iacobuzio-Donahue; Katharine E Romans; Jennifer E Axilbund; Marcia Cruz-Correa; Anne C Tersmette; G Johan A Offerhaus; Francis M Giardiello
Risk of colorectal cancer in juvenile polyposis.
Gut 2007;56(7):965-7.
2007: Antonio Jimeno; Belen Rubio-Viqueira; Maria L Amador; Victor Grunwald; Anirban Maitra; Christine A Iacobuzio-Donahue; Manuel Hidalgo
Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer.
Molecular cancer therapeutics 2007;6(3):1079-88.
2007: Georg Feldmann; Surajit Dhara; Volker Fendrich; Djahida Bedja; ROBERT BEATY; Michael Mullendore; Collins A Karikari; Hector Alvarez; Christine A Iacobuzio-Donahue; Antonio Jimeno; Kathleen L Gabrielson; William Matsui; Anirban Maitra
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Cancer research 2007;67(5):2187-96.
2007: Belen Rubio-Viqueira; Heather Mezzadra; Matthew Nielsen; Antonio Jimeno; Xianfeng Zhang; Christine A Iacobuzio-Donahue; Anirban Maitra; Manuel Hidalgo; Soner Altiok
Optimizing the development of targeted agents in pancreatic cancer: tumor fine-needle aspiration biopsy as a platform for novel prospective ex vivo drug sensitivity assays.
Molecular cancer therapeutics 2007;6(2):515-23.
2007: Jeffrey R Infante; Hiroyuki Matsubayashi; Norihiro Sato; James Tonascia; Alison P Klein; Taylor A Riall; Charles Yeo; Christine A Iacobuzio-Donahue; Michael Goggins
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(3):319-25.
2007: Raffit Hassan; Wolfgang Ebel; Eric Routhier; Rina Patel; J Bradford Kline; Jingli Zhang; Qimin Chao; Sara Jacob; Howard Turchin; Lester Gibbs; Martin D Phillips; Shiyama Mudali; Christine A Iacobuzio-Donahue; Elizabeth M Jaffee; Maria Moreno; Ira Pastan; Philip M Sass; Nicholas C Nicolaides; Luigi Grasso
Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin.
Cancer immunity 2007;7():20.
2006: Steven C Cunningham; Farin Kamangar; Min P Kim; Sommer Hammoud; Raqeeb Haque; Christine A Iacobuzio-Donahue; Raheela Ashfaq; Scott E Kern; Anirban Maitra; Richard E Heitmiller; Michael A Choti; Keith D Lillemoe; John L Cameron; Charles J Yeo; Elizabeth Montgomery; Richard D Schulick
MKK4 status predicts survival after resection of gastric adenocarcinoma.
Archives of surgery (Chicago, Ill. : 1960) 2006;141(11):1095-9; discussion 1100.
2006: Todd Sheridan; Hubert Fenton; Marc R Lewin; Ashlie L Burkart; Christine A Iacobuzio-Donahue; Wendy L Frankel; Elizabeth Montgomery
Sessile serrated adenomas with low- and high-grade dysplasia and early carcinomas: an immunohistochemical study of serrated lesions "caught in the act".
American journal of clinical pathology 2006;126(4):564-71.
2006: Eric S Calhoun; Tomas Hucl; Eike Gallmeier; Kristen M West; Dan E Arking; Anirban Maitra; Christine A Iacobuzio-Donahue; Aravinda Chakravarti; Ralph Hruban; Scott E Kern
Identifying allelic loss and homozygous deletions in pancreatic cancer without matched normals using high-density single-nucleotide polymorphism arrays.
Cancer research 2006;66(16):7920-8.
2006: Belen Rubio-Viqueira; Antonio Jimeno; George Cusatis; Xianfeng Zhang; Christine A Iacobuzio-Donahue; Collins A Karikari; Chanjuan Shi; Kathleen Danenberg; Peter V Danenberg; Hidekazu Kuramochi; Koji Tanaka; Sharat Singh; Hossein Salimi-Moosavi; Nadia Bouraoud; Maria L Amador; Soner Altiok; Piotr Kulesza; Charles Yeo; Wells A Messersmith; James R Eshleman; Ralph Hruban; Anirban Maitra; Manuel Hidalgo
An in vivo platform for translational drug development in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4652-61.
2006: Norihiro Sato; Noriyoshi Fukushima; Hiroyuki Matsubayashi; Christine A Iacobuzio-Donahue; Charles J Yeo; Michael Goggins
Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.
Cancer 2006;107(2):251-7.
2006: Valeria Sebastiani; Francesca Ricci; Belen Rubio-Viqueira; Belen Rubio-Viquiera; Piotr Kulesza; Charles J Yeo; Manuel Hidalgo; Alison P Klein; Daniel Laheru; Christine A Iacobuzio-Donahue
Immunohistochemical and genetic evaluation of deoxycytidine kinase in pancreatic cancer: relationship to molecular mechanisms of gemcitabine resistance and survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(8):2492-7.
2006: Steven C Cunningham; Farin Kamangar; Min P Kim; Sommer Hammoud; Raqeeb Haque; Christine A Iacobuzio-Donahue; Anirban Maitra; Raheela Ashfaq; Steven Hustinx; Richard E Heitmiller; Michael A Choti; Keith D Lillemoe; John L Cameron; Charles J Yeo; Richard D Schulick; Elizabeth Montgomery
Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006;15(2):281-7.
2006: Shiyama V Mudali; BAOJIN FU; Sindhu S Lakkur; Mingde Luo; Erlinda E Embuscado; Christine A Iacobuzio-Donahue
Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status.
Clinical & experimental metastasis 2006;23(7-8):357-65.
2005: Wells A Messersmith; Darin Oppenheimer; Josep Peralba; Valeria Sebastiani; Maria Amador; Antonio Jimeno; Erlinda Embuscado; Manuel Hidalgo; Christine A Iacobuzio-Donahue
Assessment of Epidermal Growth Factor Receptor (EGFR) signaling in paired colorectal cancer and normal colon tissue samples using computer-aided immunohistochemical analysis.
Cancer biology & therapy 2005;4(12):1381-6.
2005: Hiroyuki Matsubayashi; Halcyon Skinner; Christine A Iacobuzio-Donahue; Tadayoshi Abe; Norihiro Sato; Taylor S Riall; Charles J Yeo; Scott E Kern; Michael Goggins
Pancreaticobiliary cancers with deficient methylenetetrahydrofolate reductase genotypes.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2005;3(8):752-60.
2005: Lodewijk A A Brosens; Christine A Iacobuzio-Donahue; Josbert J Keller; Steven R Hustinx; Ralph Carvalho; Folkert H Morsink; Linda M Hylind; G Johan A Offerhaus; Francis M Giardiello; Michael Goggins
Increased cyclooxygenase-2 expression in duodenal compared with colonic tissues in familial adenomatous polyposis and relationship to the -765G -> C COX-2 polymorphism.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(11):4090-6.
2005: Erlinda E Embuscado; Daniel Laheru; Francesca Ricci; Ki Jung Yun; Sten de Boom Witzel; Allison Seigel; Katie Flickinger; Manuel Hidalgo; G Steven Bova; Christine A Iacobuzio-Donahue
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy.
Cancer biology & therapy 2005;4(5):548-54.
2005: Baishali Bhattacharya; Harrison Parry Dilworth; Christine A Iacobuzio-Donahue; Francesca Ricci; Kristin L Weber; Mary A Furlong; Cyril Fisher; Elizabeth Montgomery
Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions.
The American journal of surgical pathology 2005;29(5):653-9.
2005: Takashi Sakatani; Atsushi Kaneda; Christine A Iacobuzio-Donahue; Mark Carter; Sten de Boom Witzel; Hideyuki Okano; Minoru S H Ko; Rolf Ohlsson; Dan Longo; Andrew P Feinberg
Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice.
Science (New York, N.Y.) 2005;307(5717):1976-8.
2005: Francesca Ricci; Scott E Kern; Ralph Hruban; Christine A Iacobuzio-Donahue
Stromal responses to carcinomas of the pancreas: juxtatumoral gene expression conforms to the infiltrating pattern and not the biologic subtype.
Cancer biology & therapy 2005;4(3):302-7.
2005: Fikret Sahin; Wanglong Qiu; Robb E Wilentz; Christine A Iacobuzio-Donahue; Andres Grosmark; Gloria H Su
RPL38, FOSL1, and UPP1 are predominantly expressed in the pancreatic ductal epithelium.
Pancreas 2005;30(2):158-67.
2005: Norihiro Sato; Antony R Parker; Noriyoshi Fukushima; Yohei Miyagi; Christine A Iacobuzio-Donahue; James R Eshleman; Michael Goggins
Epigenetic inactivation of TFPI-2 as a common mechanism associated with growth and invasion of pancreatic ductal adenocarcinoma.
Oncogene 2005;24(5):850-8.
2005: Steven R Hustinx; Ralph Hruban; Lorenzo Leoni; Christine A Iacobuzio-Donahue; John L Cameron; Charles J Yeo; Priscilla N Brown; Pedram Argani; Raheela Ashfaq; Noriyoshi Fukushima; Michael Goggins; Scott E Kern; Anirban Maitra
Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy.
Cancer biology & therapy 2005;4(1):83-6.
2005: Robb E Wilentz; Ayman Rahman; Pedram Argani; Christine A Iacobuzio-Donahue
Immunohistochemistry and in situ hybridization in pancreatic neoplasia.
Methods in molecular medicine 2005;103():67-88.
2004: Wei Xin; Ki J Yun; Francesca Ricci; Marianna Zahurak; Wanglong Qiu; Gloria H Su; Charles J Yeo; Ralph Hruban; Scott E Kern; Christine A Iacobuzio-Donahue
MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(24):8516-20.
2004: Maria L Amador; Darin Oppenheimer; Sofia Perea; Anirban Maitra; George Cusatis; George Cusati; Christine A Iacobuzio-Donahue; Sharyn D Baker; Raheela Ashfaq; Chris Takimoto; Arlene A Forastiere; Manuel Hidalgo
An epidermal growth factor receptor intron 1 polymorphism mediates response to epidermal growth factor receptor inhibitors.
Cancer research 2004;64(24):9139-43.
2004: Steven R Hustinx; Dengfeng Cao; Anirban Maitra; Norihiro Sato; Sean T Martin; D Sudhir; Christine A Iacobuzio-Donahue; John L Cameron; Charles J Yeo; Scott E Kern; Michael Goggins; Jan Mollenhauer; Akhilesh Pandey; Ralph Hruban
Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression.
Cancer biology & therapy 2004;3(12):1254-61.
2004: N Volkan Adsay; Kambiz Merati; Olca Basturk; Christine A Iacobuzio-Donahue; Edi Levi; Jeanette D Cheng; Asfar S Azmi; Ralph Hruban; David S Klimstra
Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreas.
The American journal of surgical pathology 2004;28(7):839-48.
2004: N Tjarda van Heek; Anirban Maitra; Jens Koopmann; Neal S Fedarko; Alka Jain; Ayman Rahman; Christine A Iacobuzio-Donahue; Volkan Adsay; Raheela Ashfaq; Charles J Yeo; John L Cameron; G Johan A Offerhaus; Ralph Hruban; Karin D Berg; Michael Goggins
Gene expression profiling identifies markers of ampullary adenocarcinoma.
Cancer biology & therapy 2004;3(7):651-6.
2004: Alan K Meeker; Jessica L Hicks; Christine A Iacobuzio-Donahue; Elizabeth Montgomery; William H Westra; Theresa Y Chan; Brigitte M Ronnett; Angelo M DeMarzo
Telomere length abnormalities occur early in the initiation of epithelial carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(10):3317-26.
2004: Tian-Li Wang; Luis Alberto Diaz; Katharine E Romans; Alberto Bardelli; Saurabh Saha; Gennaro Galizia; Michael A Choti; Ross C Donehower; Giovanni Parmigiani; Ie-Ming Shih; Christine A Iacobuzio-Donahue; Kenneth W Kinzler; Bert Vogelstein; Christoph Lengauer; Victor E Velculescu
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):3089-94.
2004: Sharon L Swierczynski; Anirban Maitra; Susan C Abraham; Christine A Iacobuzio-Donahue; Raheela Ashfaq; John L Cameron; Richard D Schulick; Charles J Yeo; Ayman Rahman; David A Hinkle; Ralph Hruban; Pedram Argani
Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays.
Human pathology 2004;35(3):357-66.
2004: Christine A Iacobuzio-Donahue; Jason Song; Giovanni Parmiagiani; Charles J Yeo; Ralph Hruban; Scott E Kern
Missense mutations of MADH4: characterization of the mutational hot spot and functional consequences in human tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1597-604.
2004: Jens Koopmann; Neal S Fedarko; Alka Jain; Anirban Maitra; Christine A Iacobuzio-Donahue; Ayman Rahman; Ralph Hruban; Charles J Yeo; Michael Goggins
Evaluation of osteopontin as biomarker for pancreatic adenocarcinoma.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(3):487-91.
2004: Norihiro Sato; Noriyoshi Fukushima; Anirban Maitra; Christine A Iacobuzio-Donahue; N Tjarda van Heek; John L Cameron; Charles J Yeo; Ralph Hruban; Michael Goggins
Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas.
The American journal of pathology 2004;164(3):903-14.
2004: Christine A Iacobuzio-Donahue; Sania Shuja; Jinguo Cai; Phyllis Peng; John Willett; Mary Jo Murnane
Cathepsin D protein levels in colorectal tumors: divergent expression patterns suggest complex regulation and function.
International journal of oncology 2004;24(3):473-85.
2004: Lynette S Nichols; Raheela Ashfaq; Christine A Iacobuzio-Donahue
Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target.
American journal of clinical pathology 2004;121(2):226-30.
2004: Christine A Iacobuzio-Donahue; Michiel S van der Heijden; Mark R Baumgartner; William J Troup; Jane M Romm; Kimberly F Doheny; Elizabeth W Pugh; Charles J Yeo; Michael Goggins; Ralph Hruban; Scott E Kern
Large-scale allelotype of pancreaticobiliary carcinoma provides quantitative estimates of genome-wide allelic loss.
Cancer research 2004;64(3):871-5.
2003: Christine A Iacobuzio-Donahue; Raheela Ashfaq; Anirban Maitra; N Volkan Adsay; Grace L Shen-Ong; Karin Berg; Michael A Hollingsworth; John L Cameron; Charles J Yeo; Scott E Kern; Michael Goggins; Ralph Hruban
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies.
Cancer research 2003;63(24):8614-22.
2003: Anirban Maitra; N Volkan Adsay; Pedram Argani; Christine A Iacobuzio-Donahue; Angelo M DeMarzo; John L Cameron; Charles J Yeo; Ralph Hruban
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarray.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003;16(9):902-12.
2003: Norihiro Sato; Anirban Maitra; Noriyoshi Fukushima; N Tjarda van Heek; Hiroyuki Matsubayashi; Christine A Iacobuzio-Donahue; Christophe Rosty; Michael Goggins
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma.
Cancer research 2003;63(14):4158-66.
2003: Yoshiharu Miyamoto; Anirban Maitra; Bidyut Ghosh; Ulrich Zechner; Pedram Argani; Christine A Iacobuzio-Donahue; Virote Sriuranpong; Tatsuya Iso; Ingrid M Meszoely; Michael S Wolfe; Ralph Hruban; Douglas W Ball; Roland M Schmid; Steven D Leach
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis.
Cancer cell 2003;3(6):565-76.
2003: Jeffrey M Hardacre; Christine A Iacobuzio-Donahue; Taylor A Sohn; Susan C Abraham; Charles J Yeo; Keith D Lillemoe; Michael A Choti; Kurtis A Campbell; Richard D Schulick; Ralph Hruban; John L Cameron; Steven D Leach
Results of pancreaticoduodenectomy for lymphoplasmacytic sclerosing pancreatitis.
Annals of surgery 2003;237(6):853-8; discussion 858-9.
2003: Christine A Iacobuzio-Donahue; Ralph Hruban
Gene expression in neoplasms of the pancreas: applications to diagnostic pathology.
Advances in anatomic pathology 2003;10(3):125-34.
2003: Christine A Iacobuzio-Donahue; Anirban Maitra; Mari Olsen; Anson W Lowe; N Tjarda van Heek; Christophe Rosty; Kim Walter; Norihiro Sato; Antony Parker; Raheela Ashfaq; Elizabeth M Jaffee; Byungwoo Ryu; Jessa Jones; James R Eshleman; Charles J Yeo; John L Cameron; Scott E Kern; Ralph Hruban; Patrick O Brown; Michael Goggins
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays.
The American journal of pathology 2003;162(4):1151-62.
2003: Paula M Hempen; Lin Zhang; Ravi K Bansal; Christine A Iacobuzio-Donahue; KATHLEEN MURPHY; Anirban Maitra; Bert Vogelstein; Robert H Whitehead; Sanford D Markowitz; James Willson; Charles J Yeo; Ralph Hruban; Scott E Kern
Evidence of selection for clones having genetic inactivation of the activin A type II receptor (ACVR2) gene in gastrointestinal cancers.
Cancer research 2003;63(5):994-9.
2003: Michael G House; Mingzhou Guo; Christine A Iacobuzio-Donahue; James G Herman
Molecular progression of promoter methylation in intraductal papillary mucinous neoplasms (IPMN) of the pancreas.
Carcinogenesis 2003;24(2):193-8.
2002: Christine A Iacobuzio-Donahue; Douglas P Clark; Syed Z Ali
Reed-Sternberg-like cells in lymph node aspirates in the absence of Hodgkin's disease: pathologic significance and differential diagnosis.
Diagnostic cytopathology 2002;27(6):335-9.
2002: Christine A Iacobuzio-Donahue; Pedram Argani; Paula M Hempen; Jessa Jones; Scott E Kern
The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types.
Cancer research 2002;62(18):5351-7.
2002: Theresa Pluth Yeo; Ralph Hruban; Steven D Leach; Robb E Wilentz; Taylor A Sohn; Scott E Kern; Christine A Iacobuzio-Donahue; Anirban Maitra; Michael Goggins; Marcia Canto; Ross A. Abrams; Daniel Laheru; Elizabeth M Jaffee; Manuel Hidalgo; Charles J Yeo
Pancreatic cancer.
Current problems in cancer 2002;26(4):176-275.
2002: Anirban Maitra; Christine A Iacobuzio-Donahue; Ayman Rahman; Taylor A Sohn; Pedram Argani; Renee Meyer; Charles J Yeo; John L Cameron; Michael Goggins; Scott E Kern; Raheela Ashfaq; Ralph Hruban; Robb E Wilentz
Immunohistochemical validation of a novel epithelial and a novel stromal marker of pancreatic ductal adenocarcinoma identified by global expression microarrays: sea urchin fascin homolog and heat shock protein 47.
American journal of clinical pathology 2002;118(1):52-9.
2002: Norihiro Sato; Takashi Ueki; Noriyoshi Fukushima; Christine A Iacobuzio-Donahue; Charles J Yeo; John L Cameron; Ralph Hruban; Michael Goggins
Aberrant methylation of CpG islands in intraductal papillary mucinous neoplasms of the pancreas.
Gastroenterology 2002;123(1):365-72.
2002: Michael Torbenson; Elizabeth Montgomery; Christine A Iacobuzio-Donahue; John H. Yardley; Tsung-Teh Wu; Susan C Abraham
Colchicine effect in a colonic hyperplastic polyp. A lesion mimicking serrated adenoma.
Archives of pathology & laboratory medicine 2002;126(5):615-7.
2002: Christine A Iacobuzio-Donahue; Anirban Maitra; Grace L Shen-Ong; Tjarda van Heek; Raheela Ashfaq; Renee Meyer; Kim Walter; Karin Berg; Michael A Hollingsworth; John L Cameron; Charles J Yeo; Scott E Kern; Michael Goggins; Ralph Hruban
Discovery of novel tumor markers of pancreatic cancer using global gene expression technology.
The American journal of pathology 2002;160(4):1239-49.
2002: Christine A Iacobuzio-Donahue; Byungwoo Ryu; Ralph Hruban; Scott E Kern
Exploring the host desmoplastic response to pancreatic carcinoma: gene expression of stromal and neoplastic cells at the site of primary invasion.
The American journal of pathology 2002;160(1):91-9.
2002: Gregory Seidel; Marianna Zahurak; Christine A Iacobuzio-Donahue; Taylor A Sohn; N Volkan Adsay; Charles J Yeo; Keith D Lillemoe; John L Cameron; Ralph Hruban; Robb E Wilentz
Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 cases.
The American journal of surgical pathology 2002;26(1):56-63.
2001: Pedram Argani; Christine A Iacobuzio-Donahue; Byungwoo Ryu; Christophe Rosty; Michael Goggins; Robb E Wilentz; S R Murugesan; Steven D Leach; Elizabeth M Jaffee; Charles J Yeo; John L Cameron; Scott E Kern; Ralph Hruban
Mesothelin is overexpressed in the vast majority of ductal adenocarcinomas of the pancreas: identification of a new pancreatic cancer marker by serial analysis of gene expression (SAGE).
Clinical cancer research : an official journal of the American Association for Cancer Research 2001;7(12):3862-8.
2001: Norihiro Sato; Christophe Rosty; Marnix Jansen; Noriyoshi Fukushima; Takashi Ueki; Charles J Yeo; John L Cameron; Christine A Iacobuzio-Donahue; Ralph Hruban; Michael Goggins
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas.
The American journal of pathology 2001;159(6):2017-22.
2001: Taylor A Sohn; Charles J Yeo; John L Cameron; Christine A Iacobuzio-Donahue; Ralph Hruban; Keith D Lillemoe
Intraductal papillary mucinous neoplasms of the pancreas: an increasingly recognized clinicopathologic entity.
Annals of surgery 2001;234(3):313-21; discussion 321-2.
2001: Christine A Iacobuzio-Donahue; E L Lee; Susan C Abraham; John H. Yardley; Tsung-Teh Wu
Colchicine toxicity: distinct morphologic findings in gastrointestinal biopsies.
The American journal of surgical pathology 2001;25(8):1067-73.
2001: Ralph Hruban; Christine A Iacobuzio-Donahue; Robb E Wilentz; Michael Goggins; Scott E Kern
Molecular pathology of pancreatic cancer.
Cancer journal (Sudbury, Mass.) 2001;7(4):251-8.
2000: Christine A Iacobuzio-Donahue; Robb E Wilentz; Pedram Argani; Charles J Yeo; John L Cameron; Scott E Kern; Ralph Hruban
Dpc4 protein in mucinous cystic neoplasms of the pancreas: frequent loss of expression in invasive carcinomas suggests a role in genetic progression.
The American journal of surgical pathology 2000;24(11):1544-8.
2000: Christine A Iacobuzio-Donahue; David S Klimstra; N Volkan Adsay; Robb E Wilentz; Pedram Argani; Taylor A Sohn; Charles J Yeo; John L Cameron; Scott E Kern; Ralph Hruban
Dpc-4 protein is expressed in virtually all human intraductal papillary mucinous neoplasms of the pancreas: comparison with conventional ductal adenocarcinomas.
The American journal of pathology 2000;157(3):755-61.
2000: Robb E Wilentz; Christine A Iacobuzio-Donahue; Pedram Argani; Denis M McCarthy; J L Parsons; Charles J Yeo; Scott E Kern; Ralph Hruban
Loss of expression of Dpc4 in pancreatic intraepithelial neoplasia: evidence that DPC4 inactivation occurs late in neoplastic progression.
Cancer research 2000;60(7):2002-6.
1999: Sania Shuja; Jinguo Cai; Christine A Iacobuzio-Donahue; Jeff F Zacks; Robert M Beazley; John M Kasznica; C J O'Hara; R Heimann; Mary Jo Murnane
Cathepsin B activity and protein levels in thyroid carcinoma, Graves' disease, and multinodular goiters.
Thyroid : official journal of the American Thyroid Association 1999;9(6):569-77.
1999: Howard S Kaufman; A C Kahn; Christine A Iacobuzio-Donahue; Mark A Talamini; Keith D Lillemoe; S R Hamilton
Cytomegaloviral enterocolitis: clinical associations and outcome.
Diseases of the colon and rectum 1999;42(1):24-30.
1997: Christine A Iacobuzio-Donahue; Sania Shuja; Jinguo Cai; P Peng; Mary Jo Murnane
Elevations in cathepsin B protein content and enzyme activity occur independently of glycosylation during colorectal tumor progression.
The Journal of biological chemistry 1997;272(46):29190-9.
1997: Mary Jo Murnane; Sania Shuja; E Del Re; Jinguo Cai; Christine A Iacobuzio-Donahue; Veronica E Klepeis
Characterizing human colorectal carcinomas by proteolytic profile.
In vivo (Athens, Greece) 1997;11(3):209-16.