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Christopher Austin

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Richard Judson; Robert Kavlock; Thomas Knudsen; Matthew Martin; David Reif; Ann Richard; Raymond R Tice; Weida Tong; Maurice Whelan; William Wooge; Menghang Xia; John R Fowle; Thomas Hartung; Keith Houck; Ruili Huang; Christopher P Austin; George Daston; David Dix
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.
Richard T Eastman; Ruili Huang; Hongying Jiang; Ronald L Johnson; Lynn E Lambert; Carole A Long; Kazutoyo Miura; Sittiporn Pattaradilokrat; Dipak K Raj; Takeshi Q Tanaka; Kim C Williamson; Yimin Wu; Jing Yuan; Christopher P Austin; Bingbing Deng; Saurabh Dixit; Xin-zhuan Su
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
Miao Xu; Sally Firnkes; Christopher P Austin; Ulrich Baxa; Cristin Davidson; Sally Finkes; Ke Liu; Juan J Marugan; John C McKew; Daniel S Ory; William J Pavan; Forbes D Porter; Alan T Remaley; Rohini Sidhu; Noel Southall; Wei Sun; Manju Swaroop; Steven U Walkley; Jingbo Xiao; Wei Zheng
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders.

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All Publications

2013: Richard Judson; Robert Kavlock; Thomas Knudsen; Matthew Martin; David Reif; Ann Richard; Raymond R Tice; Weida Tong; Maurice Whelan; William Wooge; Menghang Xia; John R Fowle; Thomas Hartung; Keith Houck; Ruili Huang; Christopher P Austin; George Daston; David Dix
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.
ALTEX 2013;30(1):51-6.
2013: Richard T Eastman; Ruili Huang; Hongying Jiang; Ronald L Johnson; Lynn E Lambert; Carole A Long; Kazutoyo Miura; Sittiporn Pattaradilokrat; Dipak K Raj; Takeshi Q Tanaka; Kim C Williamson; Yimin Wu; Jing Yuan; Christopher P Austin; Bingbing Deng; Saurabh Dixit; Xin-zhuan Su
A class of tricyclic compounds blocking malaria parasite oocyst development and transmission.
Antimicrobial agents and chemotherapy 2013;57(1):425-35.
2012: Miao Xu; Sally Firnkes; Christopher P Austin; Ulrich Baxa; Cristin Davidson; Sally Finkes; Ke Liu; Juan J Marugan; John C McKew; Daniel S Ory; William J Pavan; Forbes D Porter; Alan T Remaley; Rohini Sidhu; Noel Southall; Wei Sun; Manju Swaroop; Steven U Walkley; Jingbo Xiao; Wei Zheng
δ-Tocopherol reduces lipid accumulation in Niemann-Pick type C1 and Wolman cholesterol storage disorders.
The Journal of biological chemistry 2012;287(47):39349-60.
2012: Story C Landis; Stanley E Lazic; Michael S Levine; Malcolm R Macleod; John M McCall; Richard T Moxley; Kalyani Narasimhan; Linda J Noble; Steve Perrin; John D Porter; Oswald Steward; Ellis Unger; Ursula Utz; Susan G Amara; Khusru Asadullah; Christopher P Austin; Robi Blumenstein; Eileen W Bradley; Ronald G Crystal; Robert B Darnell; Robert J Ferrante; Howard Fillit; Robert Finkelstein; Marc Fisher; Howard E Gendelman; Robert M Golub; John Goudreau; Robert A Gross; Amelie K Gubitz; Sharon E Hesterlee; David W Howells; John Huguenard; Katrina Kelner; Walter Koroshetz; Dimitri Krainc; Shai D Silberberg
A call for transparent reporting to optimize the predictive value of preclinical research.
Nature 2012;490(7419):187-91.
2012: Manju Swaroop; Natasha Thorne; Christopher P Austin; John C McKew; Mahendra S Rao; Wei Zheng
Evaluation of cholesterol reduction activity of methyl-β-cyclodextrin using differentiated human neurons and astrocytes.
Journal of biomolecular screening 2012;17(9):1243-51.
2012: Dimitrios Anastasiou; John M Asara; Douglas S Auld; Christopher P Austin; Matthew B Boxer; Kyle R Brimacombe; Lewis C Cantley; Heather R Christofk; Kevin D Courtney; Lenny Dang; Shawn M Davidson; Svetoslav Dimov; Brian P Fiske; Marian H Harris; Bum Soo Hong; James Inglese; William J Israelsen; Abhishek Jha; Jian-Kang Jiang; Shengfang Jin; Zachary R Johnson; Tahsin M Khan; Charles Kung; Kaiko Kunii; William Leister; Sophia Y Lunt; Scott Malstrom; Katherine R Mattaini; Christian M Metallo; Hee-Won Park; Francesco G Salituro; Min Shen; Amanda P Skoumbourdis; Noel Southall; Gregory Stephanopoulos; Wolfram Tempel; Craig J Thomas; Henrike Veith; Martin J Walsh; Hua Yang; Katharine E Yen; Yimin Yu; Matthew G Vander Heiden
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Nature chemical biology 2012;8(10):839-47.
2012: Lea Cunningham; Seameen Jean Dehdashti; Steven Finckbeiner; R Katherine Hyde; Kuan-Teh Jeang; Lemlem Alemu; Christopher P Austin; Juan Marugan; Yves Pommier; William C Reinhold; Raman Sood; Noel Southall; Venkat R K Yedavalli; Jing-Ruey Joanna Yeh; Ling Zhao; Wei Zheng; Paul Liu
Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFβ interaction.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(36):14592-7.
2012: Hongmao Sun; Menghang Xia; Christopher P Austin; Ruili Huang
Paradigm shift in toxicity testing and modeling.
The AAPS journal 2012;14(3):473-80.
2012: Sunita J Shukla; Steven O Simmons; Raymond R Tice; Danielle Vanleer; Kristine L Witt; Christopher P Austin; Ruili Huang; Ram Ramabhadran; Menghang Xia
Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.
Environmental health perspectives 2012;120(8):1150-6.
2012: Srilatha Sakamuru; Min Shen; Louie Shou; Raymond R Tice; Matias S Attene-Ramos; Christopher P Austin; Ruili Huang; Xiao Li; Jianming Lu; Menghang Xia
Application of a homogenous membrane potential assay to assess mitochondrial function.
Physiological genomics 2012;44(9):495-503.
2012: Jennifer T Fox; Ruili Huang; Christopher P Austin; Srilatha Sakamuru; Steven O Simmons; Nedelina Teneva; Raymond R Tice; Menghang Xia; Kyungjae Myung
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(14):5423-8.
2012: Eric F Lock; Shannon H O'Shea; Nour Abdo; Christopher P Austin; Ruili Huang; Oksana Kosyk; Alexander Sedykh; Raymond R Tice; Alexander Tropsha; Fred A Wright; Menghang Xia; Yi-Hui Zhou; Ivan Rusyn
Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model.
Toxicological sciences : an official journal of the Society of Toxicology 2012;126(2):578-88.
2012: Scott J Weir; Louis J DeGennaro; Christopher P Austin
Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnership.
Cancer research 2012;72(5):1055-8.
2012: Catherine Z Chen; Jason Hoskins; Juan J Marugan; Krzysztof Sobczak; Noel Southall; Charles A Thornton; Wei Zheng; Christopher P Austin
Two high-throughput screening assays for aberrant RNA-protein interactions in myotonic dystrophy type 1.
Analytical and bioanalytical chemistry 2012;402(5):1889-98.
2012: Steven A Titus; Christopher P Austin; Juan Marugan; Noel Southall; Wei Zheng
High-Throughput Multiplexed Quantitation of Protein Aggregation and Cytotoxicity in a Huntington's Disease Model.
Current chemical genomics 2012;6():79-86.
2012: Naris Nilubol; Min Shen; Lisa Zhang; Ya-Qin Zhang; Christopher P Austin; Mei He; Electron Kebebew
Four clinically utilized drugs were identified and validated for treatment of adrenocortical cancer using quantitative high-throughput screening.
Journal of translational medicine 2012;10():198.
2012: Ehud Goldin; Juan Marugan; Omid Motabar; Christopher P Austin; Jae Hyuk Choi; Noel Southall; Wei Zheng; Ellen Sidransky
High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase.
PloS one 2012;7(1):e29861.
2011: Hongmao Sun; Henrike Veith; Menghang Xia; Christopher P Austin; Ruili Huang
Predictive models for cytochrome p450 isozymes based on quantitative high throughput screening data.
Journal of chemical information and modeling 2011;51(10):2474-81.
2011: Jingbo Xiao; Wei Zheng; Elliot J Androphy; Jonathan J Cherry; Matthew Evans; Juan J Marugan; Noel Southall; Steve Titus; Christopher P Austin
Discovery, synthesis, and biological evaluation of novel SMN protein modulators.
Journal of medicinal chemistry 2011;54(18):6215-33.
2011: Wenwei Huang; James Inglese; Srilatha Sakamuru; Matias S Attene-Ramos; Christopher P Austin; Erika E Englund; Ruili Huang; Menghang Xia
Synthesis and evaluation of quinazolin-4-ones as hypoxia-inducible factor-1α inhibitors.
Bioorganic & medicinal chemistry letters 2011;21(18):5239-43.
2011: Jing Yuan; Thomas E Wellems; Christopher P Austin; Ken Chih-Chien Cheng; Fidock David; Rajarshi Guha; Ruili Huang; James Inglese; Ronald L Johnson; Anna Liu; Sittiporn Pattaradilokrat; Xin-zhuan Su
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
Science (New York, N.Y.) 2011;333(6043):724-9.
2011: Menghang Xia; Christopher P Austin; Vicky Guo; Ruili Huang; Marshall Nirenberg; Sampada A Shahane; Shail K Sharma
Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format.
Cellular and molecular neurobiology 2011;31(6):901-7.
2011: Ruili Huang; Richard S Judson; Robert J Kavlock; Srilatha Sakamuru; Paul Shinn; Raymond R Tice; Kristine L Witt; Menghang Xia; Ming-Hsuang Cho; David J Dix; Keith A Houck; Christopher P Austin
Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.
Environmental health perspectives 2011;119(8):1142-8.
2011: Kimiyo N Yamamoto; Kristine L Witt; Menghang Xia; Christopher P Austin; Kouji Hirota; Ruili Huang; Koichi Kono; Srilatha Sakamuru; Shunichi Takeda; Raymond R Tice
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.
Environmental and molecular mutagenesis 2011;52(7):547-61.
2011: Ronald L Johnson; Jennifer Wichterman; Jong Yeon Hwang; James Inglese; Leggy Arnold; Indre Augustinaite; Christopher P Austin; R Kiplin Guy; Ruili Huang; Wenwei Huang
A quantitative high-throughput screen identifies novel inhibitors of the interaction of thyroid receptor beta with a peptide of steroid receptor coactivator 2.
Journal of biomolecular screening 2011;16(6):618-27.
2011: Menghang Xia; Sampada A Shahane; Ruili Huang; Steven A Titus; Enoch Shum; Yong Zhao; Noel Southall; Wei Zheng; Kristine L Witt; Raymond R Tice; Christopher P Austin
Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.
Toxicology and applied pharmacology 2011;252(3):250-8.
2011: Peixiong Yuan; Tyson Tragon; Menghang Xia; Christopher A Leclair; Amanda P Skoumbourdis; Wei Zheng; Craig J Thomas; Ruili Huang; Christopher P Austin; Guang Chen; Xavier Guitart
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.
Pharmacology, biochemistry, and behavior 2011;98(3):349-55.
2011: Ruili Huang; Noel Southall; Yuhong Wang; Adam Yasgar; Paul Shinn; Ajit Jadhav; Dac-Trung Nguyen; Christopher P Austin
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics.
Science translational medicine 2011;3(80):80ps16.
2011: Jong Yeon Hwang; Wenwei Huang; Leggy Arnold; Ruili Huang; Ramy R Attia; Michele Connelly; Jennifer Wichterman; Fangyi Zhu; Indre Augustinaite; Christopher P Austin; James Inglese; Ronald L Johnson; R Kiplin Guy
Methylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.
The Journal of biological chemistry 2011;286(14):11895-908.
2011: Juan J Marugan; Wei Zheng; Omid Motabar; Noel Southall; Ehud Goldin; Wendy Westbroek; Barbara K Stubblefield; Ellen Sidransky; Ronald A Aungst; Wendy A Lea; Anton Simeonov; William Leister; Christopher P Austin
Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.
Journal of medicinal chemistry 2011;54(4):1033-58.
2011: Catherine Z Chen; Liudmila Kulakova; Noel Southall; Juan J Marugan; Andrey Galkin; Christopher P Austin; Osnat Herzberg; Wei Zheng
High-throughput Giardia lamblia viability assay using bioluminescent ATP content measurements.
Antimicrobial agents and chemotherapy 2011;55(2):667-75.
2011: Kristin P Leister; Ruili Huang; Bonnie L Goodwin; Andrew Chen; Christopher P Austin; Menghang Xia
Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells.
Current chemical genomics 2011;5():21-9.
2011: Sunita J Shukla; Srilatha Sakamuru; Ruili Huang; Timothy A Moeller; Paul Shinn; Danielle Vanleer; Douglas S Auld; Christopher P Austin; Menghang Xia
Identification of clinically used drugs that activate pregnane X receptors.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):151-9.
2010: Sunita J Shukla; Ruili Huang; Christopher P Austin; Menghang Xia
The future of toxicity testing: a focus on in vitro methods using a quantitative high-throughput screening platform.
Drug discovery today 2010;15(23-24):997-1007.
2010: Richard S Judson; Matthew T Martin; David M Reif; Keith A Houck; Thomas B Knudsen; Daniel M Rotroff; Menghang Xia; Srilatha Sakamuru; Ruili Huang; Paul Shinn; Christopher P Austin; Robert J Kavlock; David J Dix
Analysis of eight oil spill dispersants using rapid, in vitro tests for endocrine and other biological activity.
Environmental science & technology 2010;44(15):5979-85.
2010: Jian-kang Jiang; Matthew B Boxer; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Bioorganic & medicinal chemistry letters 2010;20(11):3387-93.
2010: Ke Liu; Noel Southall; Steve A Titus; James Inglese; Robert L Eskay; Paul Shinn; Christopher P Austin; Markus A Heilig; Wei Zheng
A multiplex calcium assay for identification of GPCR agonists and antagonists.
Assay and drug development technologies 2010;8(3):367-79.
2010: Juan J Marugan; Wei Zheng; Omid Motabar; Noel Southall; Ehud Goldin; Ellen Sidransky; Ronald A Aungst; Ke Liu; Subir Kumar Sadhukhan; Christopher P Austin
Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators.
European journal of medicinal chemistry 2010;45(5):1880-97.
2010: Susanne C Miller; Ruili Huang; Srilatha Sakamuru; Sunita J Shukla; Matias S Attene-Ramos; Paul Shinn; Danielle Van Leer; William Leister; Christopher P Austin; Menghang Xia
Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action.
Biochemical pharmacology 2010;79(9):1272-80.
2010: Matthew B Boxer; Jian-kang Jiang; Matthew G Vander Heiden; Min Shen; Amanda P Skoumbourdis; Noel Southall; Henrike Veith; William Leister; Christopher P Austin; Hee Won Park; James Inglese; Lewis C Cantley; Douglas S Auld; Craig J Thomas
Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase.
Journal of medicinal chemistry 2010;53(3):1048-55.
2010: Bryan T Mott; Rafaela S Ferreira; Anton Simeonov; Ajit Jadhav; Kenny Kean-Hooi Ang; William Leister; Min Shen; Julia T Silveira; Patricia S Doyle; Michelle R Arkin; James H McKerrow; James Inglese; Christopher P Austin; Craig J Thomas; Brian Shoichet; David J Maloney
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
Journal of medicinal chemistry 2010;53(1):52-60.
2010: Ajit Jadhav; Rafaela S Ferreira; Carleen Klumpp; Bryan T Mott; Christopher P Austin; James Inglese; Craig J Thomas; David J Maloney; Brian Shoichet; Anton Simeonov
Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.
Journal of medicinal chemistry 2010;53(1):37-51.
2010: Amy M Quinn; Mark T Bedford; Alexsandra Espejo; Astrid Spannhoff; Christopher P Austin; Udo Oppermann; Anton Simeonov
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.
Nucleic acids research 2010;38(2):e11.
2009: Bryan T Mott; Cordelle Tanega; Min Shen; David J Maloney; Paul Shinn; William Leister; Juan J Marugan; James Inglese; Christopher P Austin; Tom Misteli; Douglas S Auld; Craig J Thomas
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk).
Bioorganic & medicinal chemistry letters 2009;19(23):6700-5.
2009: Fred Parham; Christopher P Austin; Ruili Huang; Noel Southall; Raymond Tice; Christopher Portier
Dose-response modeling of high-throughput screening data.
Journal of biomolecular screening 2009;14(10):1216-27.
2009: Ruili Huang; Noel Southall; Menghang Xia; Ming-Hsuang Cho; Ajit Jadhav; Dac-Trung Nguyen; James Inglese; Raymond R Tice; Christopher P Austin
Weighted feature significance: a simple, interpretable model of compound toxicity based on the statistical enrichment of structural features.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(2):385-93.
2009: Samarjit Patnaik; Harry C Dietz; Wei Zheng; Christopher P Austin; Juan J Marugan
Multi-gram scale synthesis of FR180204.
The Journal of organic chemistry 2009;74(22):8870-3.
2009: Henrike Veith; Noel Southall; Ruili Huang; Tim James; Darren Fayne; Natalia Artemenko; Min Shen; James Inglese; Christopher P Austin; David Lloyd; Douglas S Auld
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.
Nature biotechnology 2009;27(11):1050-5.
2009: Steven A Titus; Daniel Beacham; Sampada A Shahane; Noel Southall; Menghang Xia; Ruili Huang; Elizabeth Hooten; Yong Zhao; Louie Shou; Christopher P Austin; Wei Zheng
A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel.
Analytical biochemistry 2009;394(1):30-8.
2009: Menghang Xia; Ruili Huang; Yi Sun; Gregg L Semenza; Shelley Force Aldred; Kristine L Witt; James Inglese; Raymond R Tice; Christopher P Austin
Identification of chemical compounds that induce HIF-1alpha activity.
Toxicological sciences : an official journal of the Society of Toxicology 2009;112(1):153-63.
2009: Ganesha Rai; Ahmed A Sayed; Wendy A Lea; Hans F Luecke; Harinath Chakrapani; Stefanie Prast-Nielsen; Ajit Jadhav; William Leister; Min Shen; James Inglese; Christopher P Austin; Larry Keefer; Elias Arnér; Anton Simeonov; David J Maloney; David L Williams; Craig J Thomas
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis.
Journal of medicinal chemistry 2009;52(20):6474-83.
2009: John T Norton; Steven A Titus; Dwayne Dexter; Christopher P Austin; Wei Zheng; Sui Huang
Automated high-content screening for compounds that disassemble the perinucleolar compartment.
Journal of biomolecular screening 2009;14(9):1045-53.
2009: Jing Yuan; Ronald L Johnson; Ruili Huang; Jennifer Wichterman; Hongying Jiang; Karen Hayton; Fidock David; Thomas E Wellems; James Inglese; Christopher P Austin; Xin-zhuan Su
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 2009;5(10):765-71.
2009: Dorjbal Dorjsuren; David M Wilson; William A Beard; John P McDonald; Christopher P Austin; Roger Woodgate; Samuel H Wilson; Anton Simeonov
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases.
Nucleic acids research 2009;37(19):e128.
2009: Ewan Birney; Thomas J Hudson; Eric D Green; Chris Gunter; Sean Eddy; Jane Rogers; Jennifer R Harris; S Dusko Ehrlich; Rolf Apweiler; Christopher P Austin; Lisa Berglund; Martin Bobrow; Chas Bountra; Anthony J Brookes; Anne Cambon-Thomsen; Nigel P Carter; Rex Chisholm; Jorge L Contreras; Robert M Cooke; William L Crosby; Ken Dewar; Richard Durbin; Stephanie O M Dyke; Joseph R Ecker; Khaled El Emam; Lars Feuk; Stacey B Gabriel; John Gallacher; William M Gelbart; Antoni Granell; Francisco Guarner; Tim Hubbard; Scott A Jackson; Jennifer L Jennings; Yann Joly; Steven M Jones; Jane Kaye; Karen L Kennedy; Bartha Maria Knoppers; Nikos Kyrpides; William W Lowrance; Jingchu Luo; John J MacKay; Luis Martín-Rivera; W Richard McCombie; John D McPherson; Linda Miller; Webb Miller; Don Moerman; Vincent Mooser; Cynthia C Morton; James M Ostell; B F Francis Ouellette; Julian Parkhill; Parminder S Raina; Christopher Rawlings; Steven E Scherer; Stephen W Scherer; Paul N Schofield; Christoph Wilhelm Sensen; Victoria C Stodden; Michael R Sussman; Toshihiro Tanaka; Janet Thornton; Tatsuhiko Tsunoda; David Valle; Eero I Vuorio; Neil M Walker; Susan Wallace; George Weinstock; William B Whitman; Kim C Worley; Cathy Wu; Jiayan Wu; Jun Yu
Prepublication data sharing.
Nature 2009;461(7261):168-70.
2009: Ronald L Johnson; Ruili Huang; Ajit Jadhav; Noel Southall; Jennifer Wichterman; Ryan MacArthur; Menghang Xia; Kun Bi; John Printen; Christopher P Austin; James Inglese
A quantitative high-throughput screen for modulators of IL-6 signaling: a model for interrogating biological networks using chemical libraries.
Molecular bioSystems 2009;5(9):1039-50.
2009: Alex Crowe; Wenwei Huang; Carlo Ballatore; Ronald L Johnson; Anne-Marie L Hogan; Ruili Huang; Jennifer Wichterman; Joshua McCoy; Donna Huryn; Douglas S Auld; Amos B Smith; James Inglese; John Q Trojanowski; Christopher P Austin; Kurt R Brunden; Virginia M-Y Lee
Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening.
Biochemistry 2009;48(32):7732-45.
2009: Zhen Wang; Min Zheng; Zhichuan Li; Ruiguo Li; Lijun Jia; Xiufang Xiong; Noel Southall; Shaomeng Wang; Menghang Xia; Christopher P Austin; Wei Zheng; Zijian Xie; Yi Sun
Cardiac glycosides inhibit p53 synthesis by a mechanism relieved by Src or MAPK inhibition.
Cancer research 2009;69(16):6556-64.
2009: Zhen-Dan Shi; Omid Motabar; Ehud Goldin; Ke Liu; Noel Southall; Ellen Sidransky; Christopher P Austin; Gary L Griffiths; Wei Zheng
Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase.
Analytical and bioanalytical chemistry 2009;394(7):1903-9.
2009: Susanne Neumann; Wenwei Huang; Steve Titus; Gerd Krause; Gunnar Kleinau; Anna Teresa Alberobello; Wei Zheng; Noel Southall; James Inglese; Christopher P Austin; Francesco S Celi; Oksana Gavrilova; Craig J Thomas; Bruce M Raaka; Marvin C Gershengorn
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12471-6.
2009: Ping Jun Zhu; John P Hobson; Noel Southall; Cunping Qiu; Craig J Thomas; Jiamo Lu; James Inglese; Wei Zheng; Stephen H Leppla; Thomas H Bugge; Christopher P Austin; Shihui Liu
Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death.
Bioorganic & medicinal chemistry 2009;17(14):5139-45.
2009: Amanda P Skoumbourdis; Christopher A Leclair; Eduard Stefan; Adrian G Turjanski; William Maguire; Steven A Titus; Ruili Huang; Douglas S Auld; James Inglese; Christopher P Austin; Stephen W Michnick; Menghang Xia; Craig J Thomas
Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors.
Bioorganic & medicinal chemistry letters 2009;19(13):3686-92.
2009: Omid Motabar; Zhen-Dan Shi; Ehud Goldin; Ke Liu; Noel Southall; Ellen Sidransky; Christopher P Austin; Gary L Griffiths; Wei Zheng
A new resorufin-based alpha-glucosidase assay for high-throughput screening.
Analytical biochemistry 2009;390(1):79-84.
2009: Kyle R Brimacombe; Matthew D Hall; Douglas S Auld; James Inglese; Christopher P Austin; Michael M Gottesman; King-Leung Fung
A dual-fluorescence high-throughput cell line system for probing multidrug resistance.
Assay and drug development technologies 2009;7(3):233-49.
2009: Ryan MacArthur; William Leister; Henrike Veith; Paul Shinn; Noel Southall; Christopher P Austin; James Inglese; Douglas S Auld
Monitoring compound integrity with cytochrome P450 assays and qHTS.
Journal of biomolecular screening 2009;14(5):538-46.
2009: Sunita J Shukla; Dac-Trung Nguyen; Ryan Macarthur; Anton Simeonov; William J Frazee; Tina M Hallis; Bryan D Marks; Upinder Singh; Hildegard C Eliason; John Printen; Christopher P Austin; James Inglese; Douglas S Auld
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.
Assay and drug development technologies 2009;7(2):143-69.
2009: Robert Kavlock; Christopher P Austin; Raymond R Tice
Toxicity testing in the 21st century: implications for human health risk assessment.
Risk analysis : an official publication of the Society for Risk Analysis 2009;29(4):485-7; discussion 492-7.
2009: Douglas S Auld; Ya-Qin Zhang; Noel Southall; Ganesha Rai; Marc Landsman; Jennifer MacLure; Daniel Langevin; Craig J Thomas; Christopher P Austin; James Inglese
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution.
Journal of medicinal chemistry 2009;52(5):1450-8.
2009: Fang Yi; Pingjun Zhu; Noel Southall; James Inglese; Christopher P Austin; Wei Zheng; Lynne Regan
An AlphaScreen-based high-throughput screen to identify inhibitors of Hsp90-cochaperone interaction.
Journal of biomolecular screening 2009;14(3):273-81.
2009: Menghang Xia; Ruili Huang; Vicky Guo; Noel Southall; Ming-Hsuang Cho; James Inglese; Christopher P Austin; Marshall Nirenberg
Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(7):2412-7.
2009: Menghang Xia; Kun Bi; Ruili Huang; Ming-Hsuang Cho; Srilatha Sakamuru; Susanne C Miller; Hua Li; Yi Sun; John Printen; Christopher P Austin; James Inglese
Identification of small molecule compounds that inhibit the HIF-1 signaling pathway.
Molecular cancer 2009;8():117.
2009: Craig J Thomas; Douglas S Auld; Ruili Huang; Wenwei Huang; Ajit Jadhav; Ronald L Johnson; William Leister; David J Maloney; Juan J Marugan; Sam Michael; Anton Simeonov; Noel Southall; Menghang Xia; Wei Zheng; James Inglese; Christopher P Austin
The pilot phase of the NIH Chemical Genomics Center.
Current topics in medicinal chemistry 2009;9(13):1181-93.
2009: Wendy A Lea; Jin Xi; Ajit Jadhav; Louis Lu; Christopher P Austin; Anton Simeonov; Roderic G Eckenhoff
A high-throughput approach for identification of novel general anesthetics.
PloS one 2009;4(9):e7150.
2009: Anton Simeonov; Avanti Kulkarni; Dorjbal Dorjsuren; Ajit Jadhav; Min Shen; Daniel R McNeill; Christopher P Austin; David M Wilson
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.
PloS one 2009;4(6):e5740.
2009: Christophe Marchand; Wendy A Lea; Ajit Jadhav; Thomas S Dexheimer; Christopher P Austin; James Inglese; Yves Pommier; Anton Simeonov
Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assay.
Molecular cancer therapeutics 2009;8(1):240-8.
2009: Hiroshi Kajiyama; Steve Titus; Christopher P Austin; Kathleen Chiotos; Takayuki Matsumoto; Toru Sakairi; Jeffrey B Kopp
Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes.
American journal of nephrology 2009;29(3):153-63.
2008: Daniel J Urban; Wei Zheng; Ozlem Goker-Alpan; Ajit Jadhav; Mary E Lamarca; James Inglese; Ellen Sidransky; Christopher P Austin
Optimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening.
Combinatorial chemistry & high throughput screening 2008;11(10):817-24.
2008: Sam Michael; Douglas S Auld; Carleen Klumpp; Ajit Jadhav; Wei Zheng; Natasha Thorne; Christopher P Austin; James Inglese; Anton Simeonov
A robotic platform for quantitative high-throughput screening.
Assay and drug development technologies 2008;6(5):637-57.
2008: Ping Jun Zhu; Wei Zheng; Douglas S Auld; Ajit Jadhav; Ryan Macarthur; Keith R Olson; Kun Peng; Hyna Dotimas; Christopher P Austin; James Inglese
A miniaturized glucocorticoid receptor translocation assay using enzymatic fragment complementation evaluated with qHTS.
Combinatorial chemistry & high throughput screening 2008;11(7):545-59.
2008: Wendy A Lea; Ajit Jadhav; Ganesha Rai; Ahmed A Sayed; Cynthia L Cass; James Inglese; David L Williams; Christopher P Austin; Anton Simeonov
A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.
Assay and drug development technologies 2008;6(4):551-5.
2008: Steven A Titus; Xiao Li; Noel Southall; Jianming Lu; James Inglese; Michael Brasch; Christopher P Austin; Wei Zheng
A cell-based PDE4 assay in 1536-well plate format for high-throughput screening.
Journal of biomolecular screening 2008;13(7):609-18.
2008: Adam Jordan Kimple; Adam Yasgar; Mark Hughes; Ajit Jadhav; Francis S Willard; Robin E Muller; Christopher P Austin; James Inglese; Gordon C Ibeanu; David Siderovski; Anton Simeonov
A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.
Combinatorial chemistry & high throughput screening 2008;11(5):396-409.
2008: Ming-Hsuang Cho; Andrew Niles; Ruili Huang; James Inglese; Christopher P Austin; Terry Riss; Menghang Xia
A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(4):1099-106.
2008: Douglas S Auld; Noel Southall; Ajit Jadhav; Ronald L Johnson; David J Diller; Anton Simeonov; Christopher P Austin; James Inglese
Characterization of chemical libraries for luciferase inhibitory activity.
Journal of medicinal chemistry 2008;51(8):2372-86.
2008: Anton Simeonov; Ajit Jadhav; Craig J Thomas; Yuhong Wang; Ruili Huang; Noel Southall; Paul Shinn; Jeremy Smith; Christopher P Austin; Douglas S Auld; James Inglese
Fluorescence spectroscopic profiling of compound libraries.
Journal of medicinal chemistry 2008;51(8):2363-71.
2008: Kerim Babaoglu; Anton Simeonov; John J Irwin; Michael E Nelson; Brian Feng; Craig J Thomas; Laura Cancian; M Paola Costi; David A Maltby; Ajit Jadhav; James Inglese; Christopher P Austin; Brian Shoichet
Comprehensive mechanistic analysis of hits from high-throughput and docking screens against beta-lactamase.
Journal of medicinal chemistry 2008;51(8):2502-11.
2008: Ronald L Johnson; Wenwei Huang; Ajit Jadhav; Christopher P Austin; James Inglese; Elisabeth D Martinez
A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.
Analytical biochemistry 2008;375(2):237-48.
2008: Ahmed A Sayed; Anton Simeonov; Craig J Thomas; James Inglese; Christopher P Austin; David L Williams
Identification of oxadiazoles as new drug leads for the control of schistosomiasis.
Nature medicine 2008;14(4):407-12.
2008: Anton Simeonov; Adam Yasgar; Ajit Jadhav; G L Lokesh; Carleen Klumpp; Sam Michael; Christopher P Austin; Amarnath Natarajan; James Inglese
Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction.
Analytical biochemistry 2008;375(1):60-70.
2008: Menghang Xia; Ruili Huang; Kristine L Witt; Noel Southall; Jennifer Fostel; Ming-Hsuang Cho; Ajit Jadhav; Cynthia S Smith; James Inglese; Christopher Portier; Raymond R Tice; Christopher P Austin
Compound cytotoxicity profiling using quantitative high-throughput screening.
Environmental health perspectives 2008;116(3):284-91.
2008: Ruili Huang; Noel Southall; Ming-Hsuang Cho; Menghang Xia; James Inglese; Christopher P Austin
Characterization of diversity in toxicity mechanism using in vitro cytotoxicity assays in quantitative high throughput screening.
Chemical research in toxicology 2008;21(3):659-67.
2008: Amanda P Skoumbourdis; Ruili Huang; Noel Southall; William Leister; Vicky Guo; Ming-Hsuang Cho; James Inglese; Marshall Nirenberg; Christopher P Austin; Menghang Xia; Craig J Thomas
Identification of a potent new chemotype for the selective inhibition of PDE4.
Bioorganic & medicinal chemistry letters 2008;18(4):1297-303.
2008: Steve Titus; Susanne Neumann; Wei Zheng; Noel Southall; Sam Michael; Carleen Klumpp; Adam Yasgar; Paul Shinn; Craig J Thomas; James Inglese; Marvin C Gershengorn; Christopher P Austin
Quantitative high-throughput screening using a live-cell cAMP assay identifies small-molecule agonists of the TSH receptor.
Journal of biomolecular screening 2008;13(2):120-7.
2008: Ke Liu; Steve Titus; Noel Southall; Pingjun Zhu; James Inglese; Christopher P Austin; Wei Zheng
Comparison on functional assays for Gq-coupled GPCRs by measuring inositol monophospate-1 and intracellular calcium in 1536-well plate format.
Current chemical genomics 2008;1():70-8.
2008: Anton Simeonov; Ajit Jadhav; Ahmed A Sayed; Yuhong Wang; Michael E Nelson; Craig J Thomas; James Inglese; David L Williams; Christopher P Austin
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade.
PLoS neglected tropical diseases 2008;2(1):e127.
2008: Yuli Xie; ShiXian Deng; Craig J Thomas; Yidong Liu; Ya-Qin Zhang; Alison Rinderspacher; Wenwei Huang; Gangli Gong; Michael Wyler; Efithia Cayanis; Nathalie Aulner; Udo Többen; Caty Chung; Sergey Pampou; Noel Southall; Dusica Vidović; Stephen Schuerer; Lars Branden; R Eric Davis; Louis M Staudt; James Inglese; Christopher P Austin; Donald W Landry; Deborah H. Smith; Douglas S Auld
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation.
Bioorganic & medicinal chemistry letters 2008;18(1):329-35.
2007: Anton Simeonov; Adam Yasgar; Carleen Klumpp; Wei Zheng; Naeem Shafqat; Udo Oppermann; Christopher P Austin; James Inglese
Evaluation of micro-parallel liquid chromatography as a method for HTS-coupled actives verification.
Assay and drug development technologies 2007;5(6):815-24.
2007: Nicolette S Honson; Ronald L Johnson; Wenwei Huang; James Inglese; Christopher P Austin; Jeffrey Kuret
Differentiating Alzheimer disease-associated aggregates with small molecules.
Neurobiology of disease 2007;28(3):251-60.
2007: Wenwei Huang; Wei Zheng; Daniel J Urban; James Inglese; Ellen Sidransky; Christopher P Austin; Craig J Thomas
N4-phenyl modifications of N2-(2-hydroxyl)ethyl-6-(pyrrolidin-1-yl)-1,3,5-triazine-2,4-diamines enhance glucocerebrosidase inhibition by small molecules with potential as chemical chaperones for Gaucher disease.
Bioorganic & medicinal chemistry letters 2007;17(21):5783-9.
2007: Wei Zheng; Janak Padia; Daniel J Urban; Ajit Jadhav; Ozlem Goker-Alpan; Anton Simeonov; Ehud Goldin; Douglas S Auld; Mary E LaMarca; James Inglese; Christopher P Austin; Ellen Sidransky
Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13192-7.
2007: James Inglese; Ronald L Johnson; Anton Simeonov; Menghang Xia; Wei Zheng; Christopher P Austin; Douglas S Auld
High-throughput screening assays for the identification of chemical probes.
Nature chemical biology 2007;3(8):466-79.
2007: David Gerhold; Ansuman Bagchi; Meiqing Lu; David Figueroa; Kevin P Keenan; Daniel J Holder; Yuhong Wang; Hong Jin; Brett Connolly; Christopher P Austin; Magdalena Alonso-Galicia
Androgens drive divergent responses to salt stress in male versus female rat kidneys.
Genomics 2007;89(6):731-44.
2007: Brian Y Feng; Anton Simeonov; Ajit Jadhav; Kerim Babaoglu; James Inglese; Brian Shoichet; Christopher P Austin
A high-throughput screen for aggregation-based inhibition in a large compound library.
Journal of medicinal chemistry 2007;50(10):2385-90.
2007: R Eric Davis; Ya-Qin Zhang; Noel Southall; Louis M Staudt; Christopher P Austin; James Inglese; Douglas S Auld
A cell-based assay for IkappaBalpha stabilization using a two-color dual luciferase-based sensor.
Assay and drug development technologies 2007;5(1):85-103.
2006: Christian N Parker; Caroline E Shamu; Brian Kraybill; Christopher P Austin; Jürgen Bajorath
Measure, mine, model, and manipulate: the future for HTS and chemoinformatics?
Drug discovery today 2006;11(19-20):863-5.
2006: James Inglese; Douglas S Auld; Ajit Jadhav; Ronald L Johnson; Anton Simeonov; Adam Yasgar; Wei Zheng; Christopher P Austin
Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11473-8.
2006: Douglas S Auld; Ronald L Johnson; Ya-qin Zhang; Henrike Veith; Ajit Jadhav; Adam Yasgar; Anton Simeonov; Wei Zheng; Elisabeth D Martinez; John K Westwick; Christopher P Austin; James Inglese
Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.
Methods in enzymology 2006;414():566-89.
2004: Christopher P Austin; Linda S Brady; Thomas R Insel; Francis S Collins
NIH Molecular Libraries Initiative.
Science (New York, N.Y.) 2004;306(5699):1138-9.
2004: Christopher P Austin; James F Battey; Allan Bradley; Maja Bucan; Mario R Capecchi; Francis S Collins; William F Dove; Geoffrey Duyk; Susan Dymecki; Janan T Eppig; Franziska B Grieder; Nathaniel Heintz; Geoff Hicks; Thomas R Insel; Alexandra L Joyner; Beverly H Koller; K C Kent Lloyd; Terry Magnuson; Mark W Moore; Andras Nagy; Jonathan D Pollock; Allen D Roses; Arthur T Sands; Brian Seed; William C Skarnes; Jay Snoddy; Philippe Soriano; David J Stewart; Francis Stewart; Bruce Stillman; Harold Varmus; Lyuba Varticovski; Inder M Verma; Thomas F Vogt; Harald von Melchner; Jan Witkowski; Richard P Woychik; Wolfgang Wurst; George D Yancopoulos; Stephen G Young; Brian Zambrowicz
The knockout mouse project.
Nature genetics 2004;36(9):921-4.
2004: Lizhen Yan; David Figueroa; Christopher P Austin; Yuan Liu; Randal M Bugianesi; Robert S Slaughter; Gregory J Kaczorowski; Martin G Kohler
Expression of voltage-gated potassium channels in human and rhesus pancreatic islets.
Diabetes 2004;53(3):597-607.
2004: Christopher P Austin; Betty Ky; Lei Ma; Jill A Morris; Paul J Shughrue
Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development.
Neuroscience 2004;124(1):3-10.
2004: Christopher P Austin
The impact of the completed human genome sequence on the development of novel therapeutics for human disease.
Annual review of medicine 2004;55():1-13.
2003: Paul J Shughrue; Betty Ky; Christopher P Austin
Localization of B1 bradykinin receptor mRNA in the primate brain and spinal cord: an in situ hybridization study.
The Journal of comparative neurology 2003;465(3):372-84.
2003: David Figueroa; Larry Borish; Dawn F Baramki; G Philip; Christopher P Austin; Jilly F Evans
Expression of cysteinyl leukotriene synthetic and signalling proteins in inflammatory cells in active seasonal allergic rhinitis.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 2003;33(10):1380-8.
2003: Jacinta B Williams; Pierre J Mallorga; Wei Lemaire; David L Williams; Sang Na; Smita Patel; Jeffrey P Conn; Douglas J Pettibone; Christopher P Austin; P Jeffrey Conn; Cyrille Sur
Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity.
Analytical biochemistry 2003;321(1):31-7.
2003: Christopher P Austin
The completed human genome: implications for chemical biology.
Current opinion in chemical biology 2003;7(4):511-5.
2003: Zhizhen Zeng; Terrence P McDonald; Ruiping Wang; Qingyun Liu; Christopher P Austin
Neuropeptide FF receptor 2 (NPFF2) is localized to pain-processing regions in the primate spinal cord and the lower level of the medulla oblongata.
Journal of chemical neuroanatomy 2003;25(4):269-78.
2003: Jill A Morris; Kandpal Geeta; Lei Ma; Christopher P Austin
DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation.
Human molecular genetics 2003;12(13):1591-608.
2003: John W Woods; Michael Tanen; David Figueroa; Chhabi Biswas; Emanuel Zycband; David E Moller; Christopher P Austin; Joel P Berger
Localization of PPARdelta in murine central nervous system: expression in oligodendrocytes and neurons.
Brain research 2003;975(1-2):10-21.
2003: Christopher P Austin; Lei Ma; Betty Ky; Jill A Morris; Paul J Shughrue
DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain.
Neuroreport 2003;14(7):951-4.
2002: Lei Ma; Yuan Liu; Betty Ky; Paul J Shughrue; Christopher P Austin; Jill A Morris
Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1).
Genomics 2002;80(6):662-72.
2002: Marc M Kurtz; Ruiping Wang; Michelle K Clements; Margaret A Cascieri; Christopher P Austin; Barry R Cunningham; Gary G Chicchi; Qingyun Liu
Identification, localization and receptor characterization of novel mammalian substance P-like peptides.
Gene 2002;296(1-2):205-12.
2002: Lex H T Van der Ploeg; William J Martin; Andrew D Howard; Ravi P Nargund; Christopher P Austin; Xiaoming Guan; Jennifer Drisko; Doreen Cashen; Iyassu Sebhat; Arthur A Patchett; David Figueroa; Anthony G DiLella; Brett M Connolly; David Weinberg; Carina P Tan; Oksana C Palyha; Sheng-Shung Pong; Tanya MacNeil; Charles Rosenblum; Aurawan Vongs; Rui Tang; Hong Yu; Andreas W Sailer; Tung Ming Fong; Cathy Huang; Michael R Tota; Ray S Chang; Ralph Stearns; Constantin Tamvakopoulos; George Christ; Deborah L Drazen; Brian D Spar; Randy J Nelson; D Euan MacIntyre
A role for the melanocortin 4 receptor in sexual function.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(17):11381-6.
2002: Stephen A Parent; Theresa Zhang; Gary Chrebet; Joseph A Clemas; David Figueroa; Betty Ky; Richard A Blevins; Christopher P Austin; Hugh Rosen
Molecular characterization of the murine SIGNR1 gene encoding a C-type lectin homologous to human DC-SIGN and DC-SIGNR.
Gene 2002;293(1-2):33-46.
2002: Carina P Tan; Hideki Sano; Hisashi Iwaasa; Jie Pan; Andreas W Sailer; Donna L Hreniuk; Scott Feighner; Oksana C Palyha; Sheng-Shung Pong; David Figueroa; Christopher P Austin; Michael M Jiang; Hong Yu; Junko Ito; Masahiko Ito; Masahiko Ito; Xiao-Ming Guan; Douglas J MacNeil; Akio Kanatani; Lex H T Van Der Ploeg; Andrew D Howard
Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression.
Genomics 2002;79(6):785-92.
2002: David Figueroa; Jill A Morris; Lei Ma; Kandpal Geeta; Elizabeth Chen; Yueming Li; Christopher P Austin
Presenilin-dependent gamma-secretase activity modulates neurite outgrowth.
Neurobiology of disease 2002;9(1):49-60.
2001: Yiqun Hui; Guang Yang; Helen Galczenski; David Figueroa; Christopher P Austin; Neal G Copeland; D J Gilbert; N A Jenkins; Colin D Funk
The murine cysteinyl leukotriene 2 (CysLT2) receptor. cDNA and genomic cloning, alternative splicing, and in vitro characterization.
The Journal of biological chemistry 2001;276(50):47489-95.
2001: Qingyun Liu; Xiao-Ming Guan; W J Martin; Terrence P McDonald; Michelle K Clements; Q Jiang; Zhizhen Zeng; M Jacobson; David L Williams; H Yu; D Bomford; David Figueroa; John J Mallee; Ruiping Wang; J Evans; R Gould; Christopher P Austin
Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception.
The Journal of biological chemistry 2001;276(40):36961-9.
2001: Michelle K Clements; Terrence P McDonald; Ruiping Wang; G Xie; Brian F O'Dowd; Susan R George; Christopher P Austin; Qingyun Liu
FMRFamide-related neuropeptides are agonists of the orphan G-protein-coupled receptor GPR54.
Biochemical and biophysical research communications 2001;284(5):1189-93.
2001: Andreas W Sailer; Hideki Sano; Zhizhen Zeng; Terrence P McDonald; Jie Pan; Sheng-Shung Pong; Scott Feighner; Carina P Tan; Takehiro Fukami; Hisashi Iwaasa; Donna L Hreniuk; Nancy R Morin; Sharon Sadowski; Masahiko Ito; M Ito; A Bansal; Betty Ky; David Figueroa; Q Jiang; Christopher P Austin; Douglas J MacNeil; Akane Ishihara; Masaki Ihara; Akio Kanatani; Lex H T Van Der Ploeg; Andrew D Howard; Qingyun Liu
Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(13):7564-9.
2001: Anthony G DiLella; Timothy J Toner; Christopher P Austin; B M Connolly
Identification of genes differentially expressed in benign prostatic hyperplasia.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2001;49(5):669-70.
2001: David Gerhold; Meiqing Lu; Jian Xu; Christopher P Austin; CT Caskey; Thomas H Rushmore
Monitoring expression of genes involved in drug metabolism and toxicology using DNA microarrays.
Physiological genomics 2001;5(4):161-70.
2001: David Figueroa; R M Breyer; S K Defoe; Stacia Kargman; B L Daugherty; K Waldburger; Q Liu; M Clements; Z Zeng; Gary P O'Neill; T R Jones; Kevin R Lynch; Christopher P Austin; Jilly F Evans
Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes.
American journal of respiratory and critical care medicine 2001;163(1):226-33.
2001: Kang Zhang; MF Kniazeva; Min Han; W Li; Z Yu; Zhenglin Yang; Yingying Li; Michael Metzker; Rando Allikmets; Donald J Zack; Laura E Kakuk; Pamela S Lagali; Paul W Wong; Ian M MacDonald; Paul Sieving; David Figueroa; Christopher P Austin; Robert Gould; Radha Ayyagari; Konstantin Petrukhin
A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.
Nature genetics 2001;27(1):89-93.
2000: David Figueroa; J Fred Hess; Betty Ky; SD Brown; V Sandig; A Hermanowski-Vosatka; Rebecca C J Twells; John A Todd; Christopher P Austin
Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2000;48(10):1357-68.
2000: CE Heise; Brian F O'Dowd; David Figueroa; Nicole Sawyer; Tuan V Nguyen; DS Im; Rino Stocco; J N Bellefeuille; Mark Abramovitz; Regina Cheng; David L Williams; Zhizhen Zeng; Qingyun Liu; L Ma; Michelle K Clements; N Coulombe; Yunhao Liu; Christopher P Austin; Susan R George; Gary P O'Neill; Kathleen M Metters; Kevin R Lynch; Jilly F Evans
Characterization of the human cysteinyl leukotriene 2 receptor.
The Journal of biological chemistry 2000;275(39):30531-6.
2000: Victor N Uebele; A Lagrutta; T Wade; David Figueroa; Y Liu; E McKenna; Christopher P Austin; Paul Bennett; R Swanson
Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel.
The Journal of biological chemistry 2000;275(30):23211-8.
2000: Andrew D Howard; R Wang; Sheng-Shung Pong; TN Mellin; Alison M Strack; Xiao-Ming Guan; Zhizhen Zeng; David L Williams; Scott Feighner; Christian N Nunes; B Murphy; J N Stair; Hong Yu; Q Jiang; Michelle K Clements; Carina P Tan; KK McKee; Donna L Hreniuk; Terrence P McDonald; Kevin R Lynch; Jilly F Evans; Christopher P Austin; CT Caskey; Lex H T Van Der Ploeg; Qingyun Liu
Identification of receptors for neuromedin U and its role in feeding.
Nature 2000;406(6791):70-4.
2000: C Bai; Brett Connolly; Michael Metzker; Cathy Hilliard; X Liu; V Sandig; A Soderman; Sheila M Galloway; Qingyun Liu; Christopher P Austin; CT Caskey
Overexpression of M68/DcR3 in human gastrointestinal tract tumors independent of gene amplification and its location in a four-gene cluster.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(3):1230-5.
2000: Y Liu; E McKenna; David Figueroa; R Blevins; Christopher P Austin; Paul Bennett; R Swanson
The human inward rectifier K(+) channel subunit kir5.1 (KCNJ16) maps to chromosome 17q25 and is expressed in kidney and pancreas.
Cytogenetics and cell genetics 2000;90(1-2):60-3.
1999: F Chen; David Figueroa; Alan D Marmorstein; Q Zhang; Konstantin Petrukhin; CT Caskey; Christopher P Austin
Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15149-54.
1999: Qingyun Liu; Sheng-Shung Pong; Zhizhen Zeng; Q Zhang; Andrew D Howard; David L Williams; M Davidoff; Ruiping Wang; Christopher P Austin; Terrence P McDonald; C Bai; Susan R George; Jilly F Evans; CT Caskey
Identification of urotensin II as the endogenous ligand for the orphan G-protein-coupled receptor GPR14.
Biochemical and biophysical research communications 1999;266(1):174-8.
1999: Scott Feighner; Carina P Tan; KK McKee; Oksana C Palyha; Donna L Hreniuk; Sheng-Shung Pong; Christopher P Austin; David Figueroa; Douglas J MacNeil; Margaret A Cascieri; Ravi P Nargund; R Bakshi; Mark Abramovitz; Rino Stocco; Stacia Kargman; Gary O'Neill; Lex H T Van Der Ploeg; J Evans; Arthur A Patchett; Roy G Smith; Andrew D Howard
Receptor for motilin identified in the human gastrointestinal system.
Science (New York, N.Y.) 1999;284(5423):2184-8.
1999: Kevin R Lynch; Gary P O'Neill; Qingyun Liu; DS Im; Nicole Sawyer; Kathleen M Metters; N Coulombe; Mark Abramovitz; David Figueroa; Zhizhen Zeng; B M Connolly; C Bai; Christopher P Austin; Anne Chateauneuf; Rino Stocco; Gillian Greig; Stacia Kargman; Shelley Hooks Pence; E Hosfield; David L Williams; AW Ford-Hutchinson; CT Caskey; Jilly F Evans
Characterization of the human cysteinyl leukotriene CysLT1 receptor.
Nature 1999;399(6738):789-93.
1999: Christopher P Austin; DJ Holder; L Ma; Lori A Mixson; CT Caskey
Mapping of hKCa3 to chromosome 1q21 and investigation of linkage of CAG repeat polymorphism to schizophrenia.
Molecular psychiatry 1999;4(3):261-6.
1998: Konstantin Petrukhin; M J Koisti; Benjamin Bakall; W Li; G Xie; Towa Marknell; Ola Sandgren; Kristina Forsman; G Holmgren; sten andreasson; M Vujic; A A Bergen; V McGarty-Dugan; David Figueroa; Christopher P Austin; Michael Metzker; CT Caskey; C Wadelius
Identification of the gene responsible for Best macular dystrophy.
Nature genetics 1998;19(3):241-7.
1996: Constance L Cepko; Christopher P Austin; X Yang; M Alexiades; D Ezzeddine
Cell fate determination in the vertebrate retina.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):589-95.
1995: Christopher P Austin; D E Feldman; J A Ida; Constance L Cepko
Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch.
Development (Cambridge, England) 1995;121(11):3637-50.
1995: Constance L Cepko; E F Ryder; Christopher P Austin; C Walsh; Donna M Fekete
Lineage analysis using retrovirus vectors.
Methods in enzymology 1995;254():387-419.
1994: Christopher P Austin; Constance L Cepko
Retrovirus mediated gene transduction into the vertebrate CNS.
Gene therapy 1994;1 Suppl 1():S6-9.
1993: Alan I Green; Christopher P Austin
Psychopathology of pancreatic cancer. A psychobiologic probe.
Psychosomatics 1993;34(3):208-21.
1993: Constance L Cepko; E F Ryder; Christopher P Austin; C Walsh; Donna M Fekete
Lineage analysis using retrovirus vectors.
Methods in enzymology 1993;225():933-60.
1991: J P Misson; Christopher P Austin; Ta Takahashi; Constance L Cepko; Verne S Caviness
The alignment of migrating neural cells in relation to the murine neopallial radial glial fiber system.
Cerebral cortex (New York, N.Y. : 1991) 1991;1(3):221-9.
1991: Christopher P Austin; Simmons Lessell
Horner's syndrome from hypothalamic infarction.
Archives of neurology 1991;48(3):332-4.
1990: Christopher P Austin; Constance L Cepko
Cellular migration patterns in the developing mouse cerebral cortex.
Development (Cambridge, England) 1990;110(3):713-32.
1990: Constance L Cepko; Christopher P Austin; C Walsh; E F Ryder; A Halliday; S Fields-Berry
Studies of cortical development using retrovirus vectors.
Cold Spring Harbor symposia on quantitative biology 1990;55():265-78.