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Hidenori Ichijo

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Kiyoshi Yamaguchi; Hisae Kadowaki; Yoshio Namba; Hideki Nishitoh; Yasuyoshi Ouchi; Kohsuke Takeda; Ikumi Ueda; Hidenori Ichijo
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.
Yusuke Sekine; Hidenori Ichijo
[Stress signaling and diseases via the ASK family kinases].
Shigeru Shiizaki; Isao Naguro; Hidenori Ichijo
Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.

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2013: Kiyoshi Yamaguchi; Hisae Kadowaki; Yoshio Namba; Hideki Nishitoh; Yasuyoshi Ouchi; Kohsuke Takeda; Ikumi Ueda; Hidenori Ichijo
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ß cell exhaustion.
Biochimica et biophysica acta 2013;1830(6):3656-63.
2013: Yusuke Sekine; Hidenori Ichijo
[Stress signaling and diseases via the ASK family kinases].
Seikagaku. The Journal of Japanese Biochemical Society 2013;85(3):167-73.
2013: Shigeru Shiizaki; Isao Naguro; Hidenori Ichijo
Activation mechanisms of ASK1 in response to various stresses and its significance in intracellular signaling.
Advances in biological regulation 2013;53(1):135-44.
2012: Yusuke Sekine; Naoki Sono; Kohsuke Takeda; Takeshi Watanabe; Shun-ichiro Iemura; Erina Kuranaga; Masayuki Miura; Tohru Natsume; Ryo Hatanaka; Hidenori Ichijo
The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.
Molecular cell 2012;48(5):692-704.
2012: Yoku Hayakawa; Yoshihiro Hirata; Hidenori Ichijo; Hiroto Kinoshita; Shin Maeda; Hayato Nakagawa; Wachiko Nakata; Kosuke Sakitani; Ryota Takahashi; Kohsuke Takeda; Kazuhiko Koike
Apoptosis signal-regulating kinase-1 inhibitor as a potent therapeutic drug for the treatment of gastric cancer.
Cancer science 2012;103(12):2181-5.
2012: Takao Fujisawa; Jun Goto; Kengo Homma; Hisae Kadowaki; Atsushi Matsuzawa; Isao Naguro; Hideki Nishitoh; Yuji Takahashi; Kohsuke Takeda; Naomi Tsuburaya; Shoji Tsuji; Namiko Yamaguchi; Hidenori Ichijo
A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.
Annals of neurology 2012;72(5):739-49.
2012: Shiori Sekine; Kohsuke Takeda; Yasuo Uchiyama; Naotada Ishihara; Miki Kamiyama; Yusuke Kanamaru; Hideyuki Kinoshita; Masato Koike; Junichi Maruyama; Ayako Nishihara; Masahiro Okada; Hidenori Ichijo
Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.
The Journal of biological chemistry 2012;287(41):34635-45.
2012: Isao Naguro; Hideki Nishitoh; Takuya Noguchi; Yutaka Shimizu; Kohsuke Takeda; Shinichi Uchida; Tsuyoshi Umeda; Alain Vandewalle; Keiichiro Kataoka; Shokei Kim-Mitsuyama; Yumie Kobayashi; Junichi Maruyama; Atsushi Matsuzawa; Kazuki Hattori; Hidenori Ichijo
ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.
Nature communications 2012;3():1285.
2012: Ryoichi Hayakawa; Teruyuki Hayakawa; Kohsuke Takeda; Hidenori Ichijo
Therapeutic targets in the ASK1-dependent stress signaling pathways.
Proceedings of the Japan Academy. Series B, Physical and biological sciences 2012;88(8):434-53.
2012: Yusuke Kanamaru; Shiori Sekine; Hidenori Ichijo; Kohsuke Takeda
The phosphorylation-dependent regulation of mitochondrial proteins in stress responses.
Journal of signal transduction 2012;2012():931215.
2012: Mayumi Soga; Atsushi Matsuzawa; Hidenori Ichijo
Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway.
International journal of cell biology 2012;2012():439587.
2012: Yosuke Ishida; Masayuki Miura; Haruka Oguchi; Yusuke Sekine; Takahiro Chihara; Hidenori Ichijo; Kohsuke Takeda
Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster.
PloS one 2012;7(2):e30265.
2011: Yusuke Sekine; Shuichi Takagahara; Kohsuke Takeda; Takeshi Toyoda; Makoto Tsunoda; Takeshi Watanabe; Takashi Funatsu; Ryo Hatanaka; Kazuto Kobayashi; Erina Kuranaga; Norio Matsuki; Masayuki Miura; Isao Naguro; Takuya Noguchi; Hiroshi Nomura; Haruka Oguchi; Hidenori Ichijo
p38 MAPKs regulate the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors.
Journal of cell science 2011;124(Pt 17):3006-16.
2011: Kohsuke Takeda; Atsushi Matsuzawa; Isao Naguro; Hideki Nishitoh; Hidenori Ichijo
Apoptosis signaling kinases: from stress response to health outcomes.
Antioxidants & redox signaling 2011;15(3):719-61.
2011: Hayato Nakagawa; Wachiko Nakata; Masao Omata; Kei Sakamoto; Takehiro Sato; Kohsuke Takeda; Haruhiko Yoshida; Yoku Hayakawa; Yohko Hikiba; Yoshihiro Hirata; Hidenori Ichijo; Hiroto Kinoshita; Kazuhiko Koike; Shin Maeda
Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated mitogen-activated protein kinase.
Hepatology (Baltimore, Md.) 2011;54(1):185-95.
2011: Christopher Runchel; Atsushi Matsuzawa; Hidenori Ichijo
Mitogen-activated protein kinases in mammalian oxidative stress responses.
Antioxidants & redox signaling 2011;15(1):205-18.
2011: Yoku Hayakawa; Yoshihiro Hirata; Hayato Nakagawa; Kei Sakamoto; Yohko Hikiba; Hiroto Kinoshita; Wachiko Nakata; Ryota Takahashi; Keisuke Tateishi; Motohisa Tada; Masao Akanuma; Haruhiko Yoshida; Kohsuke Takeda; Hidenori Ichijo; Masao Omata; Shin Maeda; Kazuhiko Koike
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(2):780-5.
2011: Masako Okamoto; Nae Saito; Hirotatsu Kojima; Takayoshi Okabe; Kohsuke Takeda; Hidenori Ichijo; Toshio Furuya; Tetsuo Nagano
Identification of novel ASK1 inhibitors using virtual screening.
Bioorganic & medicinal chemistry 2011;19(1):486-9.
2010: Takeshi Maruyama; Hisae Kadowaki; Noriaki Okamoto; Atsushi Nagai; Isao Naguro; Atsushi Matsuzawa; Hiroshi Shibuya; Keiji Tanaka; Shigeo Murata; Kohsuke Takeda; Hideki Nishitoh; Hidenori Ichijo
CHIP-dependent termination of MEKK2 regulates temporal ERK activation required for proper hyperosmotic response.
The EMBO journal 2010;29(15):2501-14.
2010: Karen Kumakura; Hiroshi Nomura; Takeshi Toyoda; Koichi Hashikawa; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo; Makoto Tsunoda; Takashi Funatsu; Daigo Ikegami; Minoru Narita; Tsutomu Suzuki; Norio Matsuki
Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice.
Neuroscience research 2010;66(3):313-20.
2010: Yoku Hayakawa; Yoshihiro Hirata; Hayato Nakagawa; Kei Sakamoto; Yohko Hikiba; Motoyuki Otsuka; Hideaki Ijichi; Tsuneo Ikenoue; Keisuke Tateishi; Masao Akanuma; Keiji Ogura; Haruhiko Yoshida; Hidenori Ichijo; Masao Omata; Shin Maeda
Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.
Gastroenterology 2010;138(3):1055-67.e1-4.
2010: Kazumi Katagiri; Atsushi Matsuzawa; Hidenori Ichijo
Regulation of apoptosis signal-regulating kinase 1 in redox signaling.
Methods in enzymology 2010;474():277-88.
2009: Hiroaki Nagai; Takuya Noguchi; Kengo Homma; Kazumi Katagiri; Kohsuke Takeda; Atsushi Matsuzawa; Hidenori Ichijo
Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.
Molecular cell 2009;36(5):805-18.
2009: Kohsuke Takeda; Yoshiko Komuro; Teruyuki Hayakawa; Haruka Oguchi; Yosuke Ishida; Shiori Murakami; Takuya Noguchi; Hideyuki Kinoshita; Yusuke Sekine; Shun-ichiro Iemura; Tohru Natsume; Hidenori Ichijo
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12301-5.
2009: Kengo Homma; Kazumi Katagiri; Hideki Nishitoh; Hidenori Ichijo
Targeting ASK1 in ER stress-related neurodegenerative diseases.
Expert opinion on therapeutic targets 2009;13(6):653-64.
2009: Takayuki Iriyama; Kohsuke Takeda; Hiromi Nakamura; Yoshifumi Morimoto; Takumi Kuroiwa; Junya Mizukami; Tsuyoshi Umeda; Takuya Noguchi; Isao Naguro; Hideki Nishitoh; Kaoru Saegusa; Kei Tobiume; Toshiki Homma; Yutaka Shimada; Hitoshi Tsuda; Satoshi Aiko; Issei Imoto; Johji Inazawa; Kazuhiro Chida; Yoshimasa Kamei; Shiro Kozuma; Yuji Taketani; Atsushi Matsuzawa; Hidenori Ichijo
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
The EMBO journal 2009;28(7):843-53.
2009: Atsushi Nagai; Hisae Kadowaki; Takeshi Maruyama; Kohsuke Takeda; Hideki Nishitoh; Hidenori Ichijo
USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
Biochemical and biophysical research communications 2009;379(4):995-1000.
2009: Kazuki Hattori; Isao Naguro; Christopher Runchel; Hidenori Ichijo
The roles of ASK family proteins in stress responses and diseases.
Cell communication and signaling : CCS 2009;7():9.
2009: Junichi Maruyama; Isao Naguro; Kohsuke Takeda; Hidenori Ichijo
Stress-activated MAP kinase cascades in cellular senescence.
Current medicinal chemistry 2009;16(10):1229-35.
2008: Atsushi Matsuzawa; Hidenori Ichijo
Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling.
Biochimica et biophysica acta 2008;1780(11):1325-36.
2008: Hayato Nakagawa; Shin Maeda; Yohko Hikiba; Tomoya Ohmae; Wataru Shibata; Ayako Yanai; Kei Sakamoto; Keiji Ogura; Takuya Noguchi; Michael Karin; Hidenori Ichijo; Masao Omata
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Gastroenterology 2008;135(4):1311-21.
2008: Hideki Nishitoh; Hisae Kadowaki; Atsushi Nagai; Takeshi Maruyama; Takanori Yokota; Hisashi Fukutomi; Takuya Noguchi; Atsushi Matsuzawa; Kohsuke Takeda; Hidenori Ichijo
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
Genes & development 2008;22(11):1451-64.
2008: Takuya Noguchi; Ken Ishii; Hisashi Fukutomi; Isao Naguro; Atsushi Matsuzawa; Kohsuke Takeda; Hidenori Ichijo
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.
The Journal of biological chemistry 2008;283(12):7657-65.
2008: Masako Taniike; Osamu Yamaguchi; Ikuko Tsujimoto; Shungo Hikoso; Toshihiro Takeda; Atsuko Nakai; Shigemiki Omiya; Isamu Mizote; Yuko Nakano; Yoshiharu Higuchi; Yasushi Matsumura; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori; Kinya Otsu
Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy.
Circulation 2008;117(4):545-52.
2008: Kohsuke Takeda; Takuya Noguchi; Isao Naguro; Hidenori Ichijo
Apoptosis signal-regulating kinase 1 in stress and immune response.
Annual review of pharmacology and toxicology 2008;48():199-225.
2007: Go Fujino; Takuya Noguchi; Atsushi Matsuzawa; Shota Yamauchi; Masao Saitoh; Kohsuke Takeda; Hidenori Ichijo
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.
Molecular and cellular biology 2007;27(23):8152-63.
2007: Shiori Murakami; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo
Stress signaling in cancer.
Cancer science 2007;98(10):1521-7.
2007: Takao Fujisawa; Kohsuke Takeda; Hidenori Ichijo
ASK family proteins in stress response and disease.
Molecular biotechnology 2007;37(1):13-8.
2007: Nao Osaka; Takumi Takahashi; Shiori Murakami; Atsushi Matsuzawa; Takuya Noguchi; Takeshi Fujiwara; Hiroyuki Aburatani; Keiji Moriyama; Kohsuke Takeda; Hidenori Ichijo
ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.
The Journal of cell biology 2007;176(7):903-9.
2007: Kohsuke Takeda; Rieko Shimozono; Takuya Noguchi; Tsuyoshi Umeda; Yoshifumi Morimoto; Isao Naguro; Kei Tobiume; Masao Saitoh; Atsushi Matsuzawa; Hidenori Ichijo
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
The Journal of biological chemistry 2007;282(10):7522-31.
2007: Genta Ito; Takuro Okai; Go Fujino; Kohsuke Takeda; Hidenori Ichijo; Toshiaki Katada; Takeshi Iwatsubo
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Biochemistry 2007;46(5):1380-8.
2007: Hiroaki Nagai; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo
Pathophysiological roles of ASK1-MAP kinase signaling pathways.
Journal of biochemistry and molecular biology 2007;40(1):1-6.
2006: Go Fujino; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo
Thioredoxin and protein kinases in redox signaling.
Seminars in cancer biology 2006;16(6):427-35.
2006: Daiju Kitagawa; Hiroaki Kajiho; Takahiro Negishi; Seiji Ura; Tomomi Watanabe; Teiji Wada; Hidenori Ichijo; Toshiaki Katada; Hiroshi Nishina
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
The EMBO journal 2006;25(14):3286-97.
2006: Toyohiko Yokoi; Keisuke Fukuo; Osamu Yasuda; Mizuo Hotta; Junichi Miyazaki; Yukihiro Takemura; Hidenobu Kawamoto; Hidenori Ichijo; Toshio Ogihara
Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells.
Diabetes 2006;55(6):1660-5.
2006: Teruyuki Hayakawa; Atsushi Matsuzawa; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo
The ASK1-MAP kinase pathways in immune and stress responses.
Microbes and infection / Institut Pasteur 2006;8(4):1098-107.
2006: Yusuke Sekine; Kohsuke Takeda; Hidenori Ichijo
The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.
Current molecular medicine 2006;6(1):87-97.
2006: Kenji Mizumura; Kohsuke Takeda; Shu Hashimoto; Takashi Horie; Hidenori Ichijo
Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.
Journal of cellular physiology 2006;206(2):363-70.
2006: Kun-Hyung Lee; Shinichi Nishimura; Shigeki Matsunaga; Nobuhiro Fusetani; Hidenori Ichijo; Sueharu Horinouchi; Minoru Yoshida
Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide.
Bioscience, biotechnology, and biochemistry 2006;70(1):161-71.
2005: Takuya Noguchi; Kohsuke Takeda; Atsushi Matsuzawa; Kaoru Saegusa; Hiroyasu Nakano; Jin Gohda; Jun-Ichiro Inoue; Hidenori Ichijo
Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death.
The Journal of biological chemistry 2005;280(44):37033-40.
2005: Tetsuya Watanabe; Kinya Otsu; Toshihiro Takeda; Osamu Yamaguchi; Shungo Hikoso; Kazunori Kashiwase; Yoshiharu Higuchi; Masako Taniike; Atsuko Nakai; Yasushi Matsumura; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.
Biochemical and biophysical research communications 2005;333(2):562-7.
2005: Fumio Kumasawa; Shu Hashimoto; Akira Onose; Itsuro Jibiki; Kenji Mizumura; Ken Matsumoto; Shuichiro Maruoka; Yasuhiro Gon; Tomoko Kobayashi; Noriaki Takahashi; Hidenori Ichijo; Takashi Horie
Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells.
European journal of pharmacology 2005;517(1-2):11-6.
2005: Atsushi Matsuzawa; Kaoru Saegusa; Takuya Noguchi; Chiharu Sadamitsu; Hideki Nishitoh; Shigenori Nagai; Shigeo Koyasu; Kunihiro Matsumoto; Kohsuke Takeda; Hidenori Ichijo
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Nature immunology 2005;6(6):587-92.
2005: Atsushi Matsuzawa; Hidenori Ichijo
Stress-responsive protein kinases in redox-regulated apoptosis signaling.
Antioxidants & redox signaling 2005;7(3-4):472-81.
2005: Hiroko Kadowaki; Hideki Nishitoh; F Urano; Chiharu Sadamitsu; Atsushi Matsuzawa; Kiyoshi Takeda; H Masutani; J Yodoi; Y Urano; T Nagano; Hidenori Ichijo
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
Cell death and differentiation 2005;12(1):19-24.
2004: Yoshiko Komuro; Kohsuke Takeda; Hidenori Ichijo
[Regulatiory mechanism of cell dealth through ASK1].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(11):1458-62.
2004: Osamu Yamaguchi; Tetsuya Watanabe; Kazuhiko Nishida; Kazunori Kashiwase; Yoshiharu Higuchi; Toshihiro Takeda; Shungo Hikoso; Shinichi Hirotani; Michio Asahi; Masako Taniike; Atsuko Nakai; Ikuko Tsujimoto; Yasushi Matsumura; Jun-ichi Miyazaki; Kenneth R Chien; Atsushi Matsuzawa; Chiharu Sadamitsu; Hidenori Ichijo; Manuela Baccarini; Masatsugu Hori; Kinya Otsu
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
The Journal of clinical investigation 2004;114(7):937-43.
2004: Hideaki Kaneto; Yoshihisa Nakatani; Takeshi Miyatsuka; Dan Kawamori; Taka-aki Matsuoka; Munehide Matsuhisa; Yoshitaka Kajimoto; Hidenori Ichijo; Yoshimitsu Yamasaki; Masatsugu Hori
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
Nature medicine 2004;10(10):1128-32.
2004: Jun Matsukawa; Atsushi Matsuzawa; Kohsuke Takeda; Hidenori Ichijo
The ASK1-MAP kinase cascades in mammalian stress response.
Journal of biochemistry 2004;136(3):261-5.
2004: Hiroko Kadowaki; Hideki Nishitoh; Hidenori Ichijo
Survival and apoptosis signals in ER stress: the role of protein kinases.
Journal of chemical neuroanatomy 2004;28(1-2):93-100.
2004: Hideki Nishitoh; Hidenori Ichijo
[Molecular mechanisms of ER stress-induced apoptosis].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(7 Suppl):1006-9.
2004: Kohsuke Takeda; Atsushi Matsuzawa; Hideki Nishitoh; Kei Tobiume; Satoshi Kishida; Jun Ninomiya-Tsuji; Kunihiro Matsumoto; Hidenori Ichijo
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
EMBO reports 2004;5(2):161-6.
2003: Osamu Yamaguchi; Yoshiharu Higuchi; Shinichi Hirotani; Kazunori Kashiwase; Hiroyuki Nakayama; Shungo Hikoso; Toshihiro Takeda; Tetsuya Watanabe; Michio Asahi; Masako Taniike; Yasushi Matsumura; Ikuko Tsujimoto; Kenichi Hongo; Yoichiro Kusakari; Satoshi Kurihara; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori; Kinya Otsu
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15883-8.
2003: Tatsuya Machino; Shu Hashimoto; Shuichiro Maruoka; Yasuhiro Gon; Shinichi Hayashi; Kenji Mizumura; Hideki Nishitoh; Hidenori Ichijo; Takashi Horie
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells.
Critical care medicine 2003;31(12):2776-81.
2003: Keiichiro Tashiro; Taku Nagao; Hitoshi Kurose; Hidenori Ichijo; Tetsuro Urushidani
Role of Rho in rabbit parietal cell.
Journal of cellular physiology 2003;197(3):409-17.
2003: Hajime Takamatsu; Taku Nagao; Hidenori Ichijo; Satomi Adachi-Akahane
L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes.
The Journal of physiology 2003;552(Pt 2):415-24.
2003: Jun Matsukawa; Kazuhisa Nakayama; Taku Nagao; Hidenori Ichijo; Tetsuro Urushidani
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
The Journal of biological chemistry 2003;278(38):36470-5.
2003: Yuichi Hashimoto; Takako Niikura; Tomohiro Chiba; Emi Tsukamoto; Hiroko Kadowaki; Hideki Nishitoh; Yohichi Yamagishi; Miho Ishizaka; Marina Yamada; Mikiro Nawa; Kenzo Terashita; Sadakazu Aiso; Hidenori Ichijo; Ikuo Nishimoto
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
The Journal of pharmacology and experimental therapeutics 2003;306(3):889-902.
2003: Shuichiro Maruoka; Shu Hashimoto; Yasuhiro Gon; Hideki Nishitoh; Ikuko Takeshita; Yasukiyo Asai; Kenji Mizumura; Kazufumi Shimizu; Hidenori Ichijo; Takashi Horie
ASK1 regulates influenza virus infection-induced apoptotic cell death.
Biochemical and biophysical research communications 2003;307(4):870-6.
2003: Shinji Yamaguchi; Boris S Zhorov; Katsuro Yoshioka; Taku Nagao; Hidenori Ichijo; Satomi Adachi-Akahane
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.
Molecular pharmacology 2003;64(2):235-48.
2003: Satoru Yamagishi; Masashi Yamada; Hisatsugu Koshimizu; Satomi Takai; Hiroshi Hatanaka; Kohsuke Takeda; Hidenori Ichijo; Koji Shimoke; Toshihiko Ikeuchi
Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons.
Journal of biochemistry 2003;133(6):719-24.
2003: Itsuro Jibiki; Shu Hashimoto; Shuichiro Maruoka; Yasuhiro Gon; Atsushi Matsuzawa; Hideki Nishitoh; Hidenori Ichijo; Takashi Horie
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.
American journal of respiratory and critical care medicine 2003;167(6):856-61.
2003: Kohsuke Takeda; Atsushi Matsuzawa; Hideki Nishitoh; Hidenori Ichijo
Roles of MAPKKK ASK1 in stress-induced cell death.
Cell structure and function 2003;28(1):23-9.
2002: Kumiko Saeki; Norihiko Kobayashi; Yuko Inazawa; Hong Zhang; Hideki Nishitoh; Hidenori Ichijo; Kumiko Saeki; Mamoru Isemura; Akira Yuo
Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.
The Biochemical journal 2002;368(Pt 3):705-20.
2002: Seiji Inoshita; Kohsuke Takeda; Takiko Hatai; Yoshio Terada; Makoto Sano; Junichi Hata; Akihiro Umezawa; Hidenori Ichijo
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress.
The Journal of biological chemistry 2002;277(46):43730-4.
2002: Hiroshi Matsuura; Hideki Nishitoh; Kohsuke Takeda; Atsushi Matsuzawa; Teruo Amagasa; Michihiko Ito; Katsuji Yoshioka; Hidenori Ichijo
Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.
The Journal of biological chemistry 2002;277(43):40703-9.
2002: Atsushi Matsuzawa; Hideki Nishitoh; Kei Tobiume; Kohsuke Takeda; Hidenori Ichijo
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Antioxidants & redox signaling 2002;4(3):415-25.
2002: Hideki Nishitoh; Atsushi Matsuzawa; Kei Tobiume; Kaoru Saegusa; Kohsuke Takeda; Kiyoshi Inoue; Seiji Hori; Akira Kakizuka; Hidenori Ichijo
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Genes & development 2002;16(11):1345-55.
2002: Kei Tobiume; Masao Saitoh; Hidenori Ichijo
Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.
Journal of cellular physiology 2002;191(1):95-104.
2001: K Morita; Masao Saitoh; Kei Tobiume; H Matsuura; S Enomoto; Hideki Nishitoh; Hidenori Ichijo
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
The EMBO journal 2001;20(21):6028-36.
2001: H Maeda; S Hori; Hideki Nishitoh; Hidenori Ichijo; O Ogawa; Y Kakehi; Akira Kakizuka
Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.
Cancer research 2001;61(14):5432-40.
2001: Atsushi Matsuzawa; Hidenori Ichijo
Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.
Journal of biochemistry 2001;130(1):1-8.
2001: Kei Tobiume; Atsushi Matsuzawa; T Takahashi; Hideki Nishitoh; K Morita; Kiyoshi Takeda; O Minowa; Kohei Miyazono; T Noda; Hidenori Ichijo
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
EMBO reports 2001;2(3):222-8.
2001: Y Sawada; K Nakamura; K Doi; Kiyoshi Takeda; Kei Tobiume; Masao Saitoh; K Morita; I Komuro; K De Vos; M Sheetz; Hidenori Ichijo
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
Journal of cell science 2001;114(Pt 6):1221-7.
2000: Y Mochida; Kiyoshi Takeda; Masao Saitoh; Hideki Nishitoh; T Amagasa; Jun Ninomiya-Tsuji; K Matsumoto; Hidenori Ichijo
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
The Journal of biological chemistry 2000;275(42):32747-52.
2000: T Hatai; Atsushi Matsuzawa; Seiji Inoshita; Y Mochida; Takayuki Kuroda; Kazuhiro Sakamaki; Keisuke Kuida; Shin Yonehara; Hidenori Ichijo; Kiyoshi Takeda
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.
The Journal of biological chemistry 2000;275(34):26576-81.
2000: T Kanamoto; M Mota; Kiyoshi Takeda; Lee L Rubin; Kohei Miyazono; Hidenori Ichijo; CE Bazenet
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.
Molecular and cellular biology 2000;20(1):196-204.
1999: M Fujii; Kiyoshi Takeda; Takeshi Imamura; H Aoki; TK Sampath; S Enomoto; M Kawabata; Mitsuyasu Kato; Hidenori Ichijo; Kohei Miyazono
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.
Molecular biology of the cell 1999;10(11):3801-13.
1998: M Saitoh; Peter ten Dijke; Kohei Miyazono; Hidenori Ichijo
Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases.
Biochemical and biophysical research communications 1998;253(2):470-6.
1998: Hideki Nishitoh; Masao Saitoh; Y Mochida; Kiyoshi Takeda; H Nakano; M Rothe; Kohei Miyazono; Hidenori Ichijo
ASK1 is essential for JNK/SAPK activation by TRAF2.
Molecular cell 1998;2(3):389-95.
1998: Kiyoshi Takeda; Hidenori Ichijo; M Fujii; Y Mochida; Masao Saitoh; Hideki Nishitoh; TK Sampath; Kohei Miyazono
Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
The Journal of biological chemistry 1998;273(27):17079-85.
1998: Masao Saitoh; Hideki Nishitoh; M Fujii; Kiyoshi Takeda; Kei Tobiume; Y Sawada; M Kawabata; Kohei Miyazono; Hidenori Ichijo
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
The EMBO journal 1998;17(9):2596-606.
1998: M Takase; Takeshi Imamura; T K Sampath; Kiyoshi Takeda; Hidenori Ichijo; Kohei Miyazono; M Kawabata
Induction of Smad6 mRNA by bone morphogenetic proteins.
Biochemical and biophysical research communications 1998;244(1):26-9.
1997: K Tobiume; T Inage; Kohsuke Takeda; S Enomoto; Kohei Miyazono; Hidenori Ichijo
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.
Biochemical and biophysical research communications 1997;239(3):905-10.
1997: H Yamashita; A Shimizu; M Kato; Hideki Nishitoh; Hidenori Ichijo; Aki Hanyu; I Morita; M Kimura; F Makishima; Kohei Miyazono
Growth/differentiation factor-5 induces angiogenesis in vivo.
Experimental cell research 1997;235(1):218-26.
1997: Hidenori Ichijo; E Nishida; K Irie; Peter ten Dijke; Masao Saitoh; T Moriguchi; M Takagi; K Matsumoto; Kohei Miyazono; Y Gotoh
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Science (New York, N.Y.) 1997;275(5296):90-4.
1996: T Okadome; E Oeda; Masao Saitoh; Hidenori Ichijo; H L Moses; Kohei Miyazono; M Kawabata
Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo.
The Journal of biological chemistry 1996;271(36):21687-90.
1996: Hideki Nishitoh; Hidenori Ichijo; M Kimura; T Matsumoto; F Makishima; A Yamaguchi; H Yamashita; S Enomoto; Kohei Miyazono
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.
The Journal of biological chemistry 1996;271(35):21345-52.
1996: Masao Saitoh; Hideki Nishitoh; T Amagasa; Kohei Miyazono; M Takagi; Hidenori Ichijo
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.
The Journal of biological chemistry 1996;271(5):2769-75.