Hidenori Ichijo

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Takeda Kohsuke; Komuro Yoshiko; Hayakawa Teruyuki; Oguchi Haruka; Ishida Yosuke; Murakami Shiori; Noguchi Takuya; Kinoshita Hideyuki; Sekine Yusuke; Iemura Shun-ichiro; Natsume Tohru; Ichijo Hidenori
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Homma Kengo; Katagiri Kazumi; Nishitoh Hideki; Ichijo Hidenori
Targeting ASK1 in ER stress-related neurodegenerative diseases.
Iriyama Takayuki; Takeda Kohsuke; Nakamura Hiromi; Morimoto Yoshifumi; Kuroiwa Takumi; Mizukami Junya; Umeda Tsuyoshi; Noguchi Takuya; Naguro Isao; Nishitoh Hideki; Saegusa Kaoru; Tobiume Kei; Homma Toshiki; Shimada Yutaka; Tsuda Hitoshi; Aiko Satoshi; Imoto Issei; Inazawa Johji; Chida Kazuhiro; Kamei Yoshimasa; Kozuma Shiro; Taketani Yuji; Matsuzawa Atsushi; Ichijo Hidenori
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.

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2009: Takeda Kohsuke; Komuro Yoshiko; Hayakawa Teruyuki; Oguchi Haruka; Ishida Yosuke; Murakami Shiori; Noguchi Takuya; Kinoshita Hideyuki; Sekine Yusuke; Iemura Shun-ichiro; Natsume Tohru; Ichijo Hidenori
Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(30):12301-5.
2009: Homma Kengo; Katagiri Kazumi; Nishitoh Hideki; Ichijo Hidenori
Targeting ASK1 in ER stress-related neurodegenerative diseases.
Expert opinion on therapeutic targets 2009;13(6):653-64.
2009: Iriyama Takayuki; Takeda Kohsuke; Nakamura Hiromi; Morimoto Yoshifumi; Kuroiwa Takumi; Mizukami Junya; Umeda Tsuyoshi; Noguchi Takuya; Naguro Isao; Nishitoh Hideki; Saegusa Kaoru; Tobiume Kei; Homma Toshiki; Shimada Yutaka; Tsuda Hitoshi; Aiko Satoshi; Imoto Issei; Inazawa Johji; Chida Kazuhiro; Kamei Yoshimasa; Kozuma Shiro; Taketani Yuji; Matsuzawa Atsushi; Ichijo Hidenori
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
The EMBO journal 2009;28(7):843-53.
2009: Nagai Atsushi; Kadowaki Hisae; Maruyama Takeshi; Takeda Kohsuke; Nishitoh Hideki; Ichijo Hidenori
USP14 inhibits ER-associated degradation via interaction with IRE1alpha.
Biochemical and biophysical research communications 2009;379(4):995-1000.
2009: Hattori Kazuki; Naguro Isao; Runchel Christopher; Ichijo Hidenori
The roles of ASK family proteins in stress responses and diseases.
Cell communication and signaling : CCS 2009;7():9.
2009: Maruyama Junichi; Naguro Isao; Takeda Kohsuke; Ichijo Hidenori
Stress-activated MAP kinase cascades in cellular senescence.
Current medicinal chemistry 2009;16(10):1229-35.
2008: Matsuzawa Atsushi; Ichijo Hidenori
Redox control of cell fate by MAP kinase: physiological roles of ASK1-MAP kinase pathway in stress signaling.
Biochimica et biophysica acta 2008;1780(11):1325-36.
2008: Nakagawa Hayato; Maeda Shin; Hikiba Yohko; Ohmae Tomoya; Shibata Wataru; Yanai Ayako; Sakamoto Kei; Ogura Keiji; Noguchi Takuya; Karin Michael; Ichijo Hidenori; Omata Masao
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
Gastroenterology 2008;135(4):1311-21.
2008: Nishitoh Hideki; Kadowaki Hisae; Nagai Atsushi; Maruyama Takeshi; Yokota Takanori; Fukutomi Hisashi; Noguchi Takuya; Matsuzawa Atsushi; Takeda Kohsuke; Ichijo Hidenori
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
Genes & development 2008;22(11):1451-64.
2008: Noguchi Takuya; Ishii Ken; Fukutomi Hisashi; Naguro Isao; Matsuzawa Atsushi; Takeda Kohsuke; Ichijo Hidenori
Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.
The Journal of biological chemistry 2008;283(12):7657-65.
2008: Taniike Masayuki; Yamaguchi Osamu; Tsujimoto Ikuko; Hikoso Shungo; Takeda Toshihiro; Nakai Atsuko; Omiya Shigemiki; Mizote Isamu; Nakano Yuko; Higuchi Yoshiharu; Matsumura Yasushi; Nishida Kazuhiko; Ichijo Hidenori; Hori Masatsugu; Otsu Kinya
Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy.
Circulation 2008;117(4):545-52.
2008: Takeda Kohsuke; Noguchi Takuya; Naguro Isao; Ichijo Hidenori
Apoptosis signal-regulating kinase 1 in stress and immune response.
Annual review of pharmacology and toxicology 2008;48():199-225.
2007: Fujino Go; Noguchi Takuya; Matsuzawa Atsushi; Yamauchi Shota; Saitoh Masao; Takeda Kohsuke; Ichijo Hidenori
Thioredoxin and TRAF family proteins regulate reactive oxygen species-dependent activation of ASK1 through reciprocal modulation of the N-terminal homophilic interaction of ASK1.
Molecular and cellular biology 2007;27(23):8152-63.
2007: Murakami Shiori; Noguchi Takuya; Takeda Kohsuke; Ichijo Hidenori
Stress signaling in cancer.
Cancer science 2007;98(10):1521-7.
2007: Fujisawa Takao; Takeda Kohsuke; Ichijo Hidenori
ASK family proteins in stress response and disease.
Molecular biotechnology 2007;37(1):13-8.
2007: Osaka Nao; Takahashi Takumi; Murakami Shiori; Matsuzawa Atsushi; Noguchi Takuya; Fujiwara Takeshi; Aburatani Hiroyuki; Moriyama Keiji; Takeda Kohsuke; Ichijo Hidenori
ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.
The Journal of cell biology 2007;176(7):903-9.
2007: Takeda Kohsuke; Shimozono Rieko; Noguchi Takuya; Umeda Tsuyoshi; Morimoto Yoshifumi; Naguro Isao; Tobiume Kei; Saitoh Masao; Matsuzawa Atsushi; Ichijo Hidenori
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
The Journal of biological chemistry 2007;282(10):7522-31.
2007: Ito Genta; Okai Takuro; Fujino Go; Takeda Kohsuke; Ichijo Hidenori; Katada Toshiaki; Iwatsubo Takeshi
GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.
Biochemistry 2007;46(5):1380-8.
2007: Nagai Hiroaki; Noguchi Takuya; Takeda Kohsuke; Ichijo Hidenori
Pathophysiological roles of ASK1-MAP kinase signaling pathways.
Journal of biochemistry and molecular biology 2007;40(1):1-6.
2006: Fujino Go; Noguchi Takuya; Takeda Kohsuke; Ichijo Hidenori
Thioredoxin and protein kinases in redox signaling.
Seminars in cancer biology 2006;16(6):427-35.
2006: Kitagawa Daiju; Kajiho Hiroaki; Negishi Takahiro; Ura Seiji; Watanabe Tomomi; Wada Teiji; Ichijo Hidenori; Katada Toshiaki; Nishina Hiroshi
Release of RASSF1C from the nucleus by Daxx degradation links DNA damage and SAPK/JNK activation.
The EMBO journal 2006;25(14):3286-97.
2006: Yokoi Toyohiko; Fukuo Keisuke; Yasuda Osamu; Hotta Mizuo; Miyazaki Junichi; Takemura Yukihiro; Kawamoto Hidenobu; Ichijo Hidenori; Ogihara Toshio
Apoptosis signal-regulating kinase 1 mediates cellular senescence induced by high glucose in endothelial cells.
Diabetes 2006;55(6):1660-5.
2006: Hayakawa Teruyuki; Matsuzawa Atsushi; Noguchi Takuya; Takeda Kohsuke; Ichijo Hidenori
The ASK1-MAP kinase pathways in immune and stress responses.
Microbes and infection / Institut Pasteur 2006;8(4):1098-107.
2006: Sekine Yusuke; Takeda Kohsuke; Ichijo Hidenori
The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases.
Current molecular medicine 2006;6(1):87-97.
2006: Mizumura Kenji; Takeda Kohsuke; Hashimoto Shu; Horie Takashi; Ichijo Hidenori
Identification of Op18/stathmin as a potential target of ASK1-p38 MAP kinase cascade.
Journal of cellular physiology 2006;206(2):363-70.
2006: Lee Kun-Hyung; Nishimura Shinichi; Matsunaga Shigeki; Fusetani Nobuhiro; Ichijo Hidenori; Horinouchi Sueharu; Yoshida Minoru
Induction of a ribotoxic stress response that stimulates stress-activated protein kinases by 13-deoxytedanolide, an antitumor marine macrolide.
Bioscience, biotechnology, and biochemistry 2006;70(1):161-71.
2005: Noguchi Takuya; Takeda Kohsuke; Matsuzawa Atsushi; Saegusa Kaoru; Nakano Hiroyasu; Gohda Jin; Inoue Jun-Ichiro; Ichijo Hidenori
Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death.
The Journal of biological chemistry 2005;280(44):37033-40.
2005: Kumasawa Fumio; Hashimoto Shu; Onose Akira; Jibiki Itsuro; Mizumura Kenji; Matsumoto Ken; Maruoka Shuichiro; Gon Yasuhiro; Kobayashi Tomoko; Takahashi Noriaki; Ichijo Hidenori; Horie Takashi
Apoptosis signal-regulating kinase 1 in leukotriene D(4)-induced activator protein-1 activation in airway smooth muscle cells.
European journal of pharmacology 2005;517(1-2):11-6.
2005: Watanabe Tetsuya; Otsu Kinya; Takeda Toshihiro; Yamaguchi Osamu; Hikoso Shungo; Kashiwase Kazunori; Higuchi Yoshiharu; Taniike Masayuki; Nakai Atsuko; Matsumura Yasushi; Nishida Kazuhiko; Ichijo Hidenori; Hori Masatsugu
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.
Biochemical and biophysical research communications 2005;333(2):562-7.
2005: Matsuzawa Atsushi; Saegusa Kaoru; Noguchi Takuya; Sadamitsu Chiharu; Nishitoh Hideki; Nagai Shigenori; Koyasu Shigeo; Matsumoto Kunihiro; Takeda Kohsuke; Ichijo Hidenori
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.
Nature immunology 2005;6(6):587-92.
2005: Matsuzawa Atsushi; Ichijo Hidenori
Stress-responsive protein kinases in redox-regulated apoptosis signaling.
Antioxidants & redox signaling 2005;7(3-4):472-81.
2005: Kadowaki H; Nishitoh H; Urano F; Sadamitsu C; Matsuzawa A; Takeda K; Masutani H; Yodoi J; Urano Y; Nagano T; Ichijo H
Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation.
Cell death and differentiation 2005;12(1):19-24.
2004: Komuro Yoshiko; Takeda Kohsuke; Ichijo Hidenori
[Regulatiory mechanism of cell dealth through ASK1]
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(11):1458-62.
2004: Yamaguchi Osamu; Watanabe Tetsuya; Nishida Kazuhiko; Kashiwase Kazunori; Higuchi Yoshiharu; Takeda Toshihiro; Hikoso Shungo; Hirotani Shinichi; Asahi Michio; Taniike Masayuki; Nakai Atsuko; Tsujimoto Ikuko; Matsumura Yasushi; Miyazaki Jun-ichi; Chien Kenneth R; Matsuzawa Atsushi; Sadamitsu Chiharu; Ichijo Hidenori; Baccarini Manuela; Hori Masatsugu; Otsu Kinya
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
The Journal of clinical investigation 2004;114(7):937-43.
2004: Kaneto Hideaki; Nakatani Yoshihisa; Miyatsuka Takeshi; Kawamori Dan; Matsuoka Taka-aki; Matsuhisa Munehide; Kajimoto Yoshitaka; Ichijo Hidenori; Yamasaki Yoshimitsu; Hori Masatsugu
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
Nature medicine 2004;10(10):1128-32.
2004: Matsukawa Jun; Matsuzawa Atsushi; Takeda Kohsuke; Ichijo Hidenori
The ASK1-MAP kinase cascades in mammalian stress response.
Journal of biochemistry 2004;136(3):261-5.
2004: Kadowaki Hisae; Nishitoh Hideki; Ichijo Hidenori
Survival and apoptosis signals in ER stress: the role of protein kinases.
Journal of chemical neuroanatomy 2004;28(1-2):93-100.
2004: Nishitoh Hideki; Ichijo Hidenori
[Molecular mechanisms of ER stress-induced apoptosis]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2004;49(7 Suppl):1006-9.
2004: Takeda Kohsuke; Matsuzawa Atsushi; Nishitoh Hideki; Tobiume Kei; Kishida Satoshi; Ninomiya-Tsuji Jun; Matsumoto Kunihiro; Ichijo Hidenori
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.
EMBO reports 2004;5(2):161-6.
2003: Machino Tatsuya; Hashimoto Shu; Maruoka Shuichiro; Gon Yasuhiro; Hayashi Shinichi; Mizumura Kenji; Nishitoh Hideki; Ichijo Hidenori; Horie Takashi
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates hydrogen peroxide-induced apoptosis in human pulmonary vascular endothelial cells.
Critical care medicine 2003;31(12):2776-81.
2003: Yamaguchi Osamu; Higuchi Yoshiharu; Hirotani Shinichi; Kashiwase Kazunori; Nakayama Hiroyuki; Hikoso Shungo; Takeda Toshihiro; Watanabe Tetsuya; Asahi Michio; Taniike Masayuki; Matsumura Yasushi; Tsujimoto Ikuko; Hongo Kenichi; Kusakari Yoichiro; Kurihara Satoshi; Nishida Kazuhiko; Ichijo Hidenori; Hori Masatsugu; Otsu Kinya
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15883-8.
2003: Tashiro Keiichiro; Nagao Taku; Kurose Hitoshi; Ichijo Hidenori; Urushidani Tetsuro
Role of Rho in rabbit parietal cell.
Journal of cellular physiology 2003;197(3):409-17.
2003: Takamatsu Hajime; Nagao Taku; Ichijo Hidenori; Adachi-Akahane Satomi
L-type Ca2+ channels serve as a sensor of the SR Ca2+ for tuning the efficacy of Ca2+-induced Ca2+ release in rat ventricular myocytes.
The Journal of physiology 2003;552(Pt 2):415-24.
2003: Matsukawa Jun; Nakayama Kazuhisa; Nagao Taku; Ichijo Hidenori; Urushidani Tetsuro
Role of ADP-ribosylation factor 6 (ARF6) in gastric acid secretion.
The Journal of biological chemistry 2003;278(38):36470-5.
2003: Hashimoto Yuichi; Niikura Takako; Chiba Tomohiro; Tsukamoto Emi; Kadowaki Hisae; Nishitoh Hideki; Yamagishi Yohichi; Ishizaka Miho; Yamada Marina; Nawa Mikiro; Terashita Kenzo; Aiso Sadakazu; Ichijo Hidenori; Nishimoto Ikuo
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.
The Journal of pharmacology and experimental therapeutics 2003;306(3):889-902.
2003: Maruoka Shuichiro; Hashimoto Shu; Gon Yasuhiro; Nishitoh Hideki; Takeshita Ikuko; Asai Yasukiyo; Mizumura Kenji; Shimizu Kazufumi; Ichijo Hidenori; Horie Takashi
ASK1 regulates influenza virus infection-induced apoptotic cell death.
Biochemical and biophysical research communications 2003;307(4):870-6.
2003: Yamaguchi Shinji; Zhorov Boris S; Yoshioka Katsuro; Nagao Taku; Ichijo Hidenori; Adachi-Akahane Satomi
Key roles of Phe1112 and Ser1115 in the pore-forming IIIS5-S6 linker of L-type Ca2+ channel alpha1C subunit (CaV 1.2) in binding of dihydropyridines and action of Ca2+ channel agonists.
Molecular pharmacology 2003;64(2):235-48.
2003: Yamagishi Satoru; Yamada Masashi; Koshimizu Hisatsugu; Takai Satomi; Hatanaka Hiroshi; Takeda Kohsuke; Ichijo Hidenori; Shimoke Koji; Ikeuchi Toshihiko
Apoptosis-signal regulating kinase-1 is involved in the low potassium-induced activation of p38 mitogen-activated protein kinase and c-Jun in cultured cerebellar granule neurons.
Journal of biochemistry 2003;133(6):719-24.
2003: Jibiki Itsuro; Hashimoto Shu; Maruoka Shuichiro; Gon Yasuhiro; Matsuzawa Atsushi; Nishitoh Hideki; Ichijo Hidenori; Horie Takashi
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cells.
American journal of respiratory and critical care medicine 2003;167(6):856-61.
2003: Takeda Kohsuke; Matsuzawa Atsushi; Nishitoh Hideki; Ichijo Hidenori
Roles of MAPKKK ASK1 in stress-induced cell death.
Cell structure and function 2003;28(1):23-9.
2002: Saeki Koichi; Kobayashi Norihiko; Inazawa Yuko; Zhang Hong; Nishitoh Hideki; Ichijo Hidenori; Saeki Kumiko; Isemura Mamoru; Yuo Akira
Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis.
The Biochemical journal 2002;368(Pt 3):705-20.
2002: Inoshita Seiji; Takeda Kohsuke; Hatai Takiko; Terada Yoshio; Sano Makoto; Hata Junichi; Umezawa Akihiro; Ichijo Hidenori
Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress.
The Journal of biological chemistry 2002;277(46):43730-4.
2002: Matsuura Hiroshi; Nishitoh Hideki; Takeda Kohsuke; Matsuzawa Atsushi; Amagasa Teruo; Ito Michihiko; Yoshioka Katsuji; Ichijo Hidenori
Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade.
The Journal of biological chemistry 2002;277(43):40703-9.
2002: Matsuzawa Atsushi; Nishitoh Hideki; Tobiume Kei; Takeda Kohsuke; Ichijo Hidenori
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Antioxidants & redox signaling 2002;4(3):415-25.
2002: Nishitoh Hideki; Matsuzawa Atsushi; Tobiume Kei; Saegusa Kaoru; Takeda Kohsuke; Inoue Kiyoshi; Hori Seiji; Kakizuka Akira; Ichijo Hidenori
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats.
Genes & development 2002;16(11):1345-55.
2002: Tobiume Kei; Saitoh Masao; Ichijo Hidenori
Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.
Journal of cellular physiology 2002;191(1):95-104.
2001: Morita K; Saitoh M; Tobiume K; Matsuura H; Enomoto S; Nishitoh H; Ichijo H
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress.
The EMBO journal 2001;20(21):6028-36.
2001: Maeda H; Hori S; Nishitoh H; Ichijo H; Ogawa O; Kakehi Y; Kakizuka A
Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgen-independent prostate cancer.
Cancer research 2001;61(14):5432-40.
2001: Matsuzawa A; Ichijo H
Molecular mechanisms of the decision between life and death: regulation of apoptosis by apoptosis signal-regulating kinase 1.
Journal of biochemistry 2001;130(1):1-8.
2001: Tobiume K; Matsuzawa A; Takahashi T; Nishitoh H; Morita K; Takeda K; Minowa O; Miyazono K; Noda T; Ichijo H
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.
EMBO reports 2001;2(3):222-8.
2001: Sawada Y; Nakamura K; Doi K; Takeda K; Tobiume K; Saitoh M; Morita K; Komuro I; De Vos K; Sheetz M; Ichijo H
Rap1 is involved in cell stretching modulation of p38 but not ERK or JNK MAP kinase.
Journal of cell science 2001;114(Pt 6):1221-7.
2000: Mochida Y; Takeda K; Saitoh M; Nishitoh H; Amagasa T; Ninomiya-Tsuji J; Matsumoto K; Ichijo H
ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction.
The Journal of biological chemistry 2000;275(42):32747-52.
2000: Hatai T; Matsuzawa A; Inoshita S; Mochida Y; Kuroda T; Sakamaki K; Kuida K; Yonehara S; Ichijo H; Takeda K
Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation.
The Journal of biological chemistry 2000;275(34):26576-81.
2000: Kanamoto T; Mota M; Takeda K; Rubin L L; Miyazono K; Ichijo H; Bazenet C E
Role of apoptosis signal-regulating kinase in regulation of the c-Jun N-terminal kinase pathway and apoptosis in sympathetic neurons.
Molecular and cellular biology 2000;20(1):196-204.
1999: Fujii M; Takeda K; Imamura T; Aoki H; Sampath T K; Enomoto S; Kawabata M; Kato M; Ichijo H; Miyazono K
Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation.
Molecular biology of the cell 1999;10(11):3801-13.
1998: Saitoh M; ten Dijke P; Miyazono K; Ichijo H
Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases.
Biochemical and biophysical research communications 1998;253(2):470-6.
1998: Nishitoh H; Saitoh M; Mochida Y; Takeda K; Nakano H; Rothe M; Miyazono K; Ichijo H
ASK1 is essential for JNK/SAPK activation by TRAF2.
Molecular cell 1998;2(3):389-95.
1998: Takeda K; Ichijo H; Fujii M; Mochida Y; Saitoh M; Nishitoh H; Sampath T K; Miyazono K
Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.
The Journal of biological chemistry 1998;273(27):17079-85.
1998: Saitoh M; Nishitoh H; Fujii M; Takeda K; Tobiume K; Sawada Y; Kawabata M; Miyazono K; Ichijo H
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.
The EMBO journal 1998;17(9):2596-606.
1998: Takase M; Imamura T; Sampath T K; Takeda K; Ichijo H; Miyazono K; Kawabata M
Induction of Smad6 mRNA by bone morphogenetic proteins.
Biochemical and biophysical research communications 1998;244(1):26-9.
1997: Tobiume K; Inage T; Takeda K; Enomoto S; Miyazono K; Ichijo H
Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.
Biochemical and biophysical research communications 1997;239(3):905-10.
1997: Yamashita H; Shimizu A; Kato M; Nishitoh H; Ichijo H; Hanyu A; Morita I; Kimura M; Makishima F; Miyazono K
Growth/differentiation factor-5 induces angiogenesis in vivo.
Experimental cell research 1997;235(1):218-26.
1997: Ichijo H; Nishida E; Irie K; ten Dijke P; Saitoh M; Moriguchi T; Takagi M; Matsumoto K; Miyazono K; Gotoh Y
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways.
Science (New York, N.Y.) 1997;275(5296):90-4.
1996: Okadome T; Oeda E; Saitoh M; Ichijo H; Moses H L; Miyazono K; Kawabata M
Characterization of the interaction of FKBP12 with the transforming growth factor-beta type I receptor in vivo.
The Journal of biological chemistry 1996;271(36):21687-90.
1996: Nishitoh H; Ichijo H; Kimura M; Matsumoto T; Makishima F; Yamaguchi A; Yamashita H; Enomoto S; Miyazono K
Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5.
The Journal of biological chemistry 1996;271(35):21345-52.
1996: Saitoh M; Nishitoh H; Amagasa T; Miyazono K; Takagi M; Ichijo H
Identification of important regions in the cytoplasmic juxtamembrane domain of type I receptor that separate signaling pathways of transforming growth factor-beta.
The Journal of biological chemistry 1996;271(5):2769-75.

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