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Iekuni Ichikawa

Research Profile

Anatomy

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Glomerular Filtration Rate

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Taiji Matsusaka; Fumio Niimura; Akira Nishiyama; Ira Pastan; Akihiko Saito; Akihiro Shimizu; Hiroyuki Kobori; Iekuni Ichikawa
Liver angiotensinogen is the primary source of renal angiotensin II.
Nobuaki Takagi; Takakuni Tanizawa; Agnes B Fogo; Iekuni Ichikawa; Valentina Kon; Ji Ma
Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis.
Suguru Yamamoto; Patricia G Yancey; Yiqin Zuo; MacRae F Linton; Li-Jun Ma; Sergio Fazio; Agnes B Fogo; Iekuni Ichikawa; Ryohei Kaseda; Valentina Kon
Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.

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2012: Taiji Matsusaka; Fumio Niimura; Akira Nishiyama; Ira Pastan; Akihiko Saito; Akihiro Shimizu; Hiroyuki Kobori; Iekuni Ichikawa
Liver angiotensinogen is the primary source of renal angiotensin II.
Journal of the American Society of Nephrology : JASN 2012;23(7):1181-9.
2012: Nobuaki Takagi; Takakuni Tanizawa; Agnes B Fogo; Iekuni Ichikawa; Valentina Kon; Ji Ma
Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis.
Nephron extra 2012;2(1):17-26.
2011: Suguru Yamamoto; Patricia G Yancey; Yiqin Zuo; MacRae F Linton; Li-Jun Ma; Sergio Fazio; Agnes B Fogo; Iekuni Ichikawa; Ryohei Kaseda; Valentina Kon
Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(12):2856-64.
2011: Taiji Matsusaka; Ira Pastan; Eric Sandgren; Ayumi Shintani; Agnes B Fogo; Valentina Kon; Iekuni Ichikawa
Podocyte injury damages other podocytes.
Journal of the American Society of Nephrology : JASN 2011;22(7):1275-85.
2011: Ji Ma; Taiji Matsusaka; Nobuaki Takagi; Hai-Chun Yang; Jianyong Zhong; Agnes B Fogo; Valentina Kon; Iekuni Ichikawa
Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside.
Pediatric research 2011;70(1):83-9.
2011: Taiji Matsusaka; Kazuto Kobayashi; Valentina Kon; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa
Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection.
American journal of physiology. Renal physiology 2011;300(3):F792-800.
2010: Taiji Matsusaka; Takako Asano; Fumio Niimura; Masaru Kinomura; Akihiro Shimizu; Ayumi Shintani; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa
Angiotensin receptor blocker protection against podocyte-induced sclerosis is podocyte angiotensin II type 1 receptor-independent.
Hypertension 2010;55(4):967-73.
2010: Masaru Motojima; Taiji Matsusaka; Valentina Kon; Iekuni Ichikawa
Fibrinogen that appears in Bowman's space of proteinuric kidneys in vivo activates podocyte Toll-like receptors 2 and 4 in vitro.
Nephron. Experimental nephrology 2010;114(2):e39-47.
2009: Yiqin Zuo; Patricia G Yancey; Iris Castro; Wasif Khan; Wasif Khan; Masaru Motojima; Iekuni Ichikawa; Agnes B Fogo; MacRae F Linton; Sergio Fazio; Valentina Kon
Renal dysfunction potentiates foam cell formation by repressing ABCA1.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(9):1277-82.
2009: Taisei Suzuki; Taiji Matsusaka; Makiko Nakayama; Takako Asano; Teruo Watanabe; Iekuni Ichikawa; Michio Nagata
Genetic podocyte lineage reveals progressive podocytopenia with parietal cell hyperplasia in a murine model of cellular/collapsing focal segmental glomerulosclerosis.
The American journal of pathology 2009;174(5):1675-82.
2009: Tomonori Hirose; Daisuke Satoh; Hidetake Kurihara; Chiho Kusaka; Hiroko Hirose; Kazunori Akimoto; Taiji Matsusaka; Iekuni Ichikawa; Tetsuo Noda; Shigeo Ohno
An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms.
PloS one 2009;4(1):e4194.
2008: Yaeko Motoyoshi; Taiji Matsusaka; Akihiko Saito; Ira Pastan; Thomas E Willnow; Shuki Mizutani; Iekuni Ichikawa
Megalin contributes to the early injury of proximal tubule cells during nonselective proteinuria.
Kidney international 2008;74(10):1262-9.
2008: Hiroyuki Ueda; Yoichi Miyazaki; Taiji Matsusaka; Yasunori Utsunomiya; Tetsuya Kawamura; Tatsuo Hosoya; Iekuni Ichikawa
Bmp in podocytes is essential for normal glomerular capillary formation.
Journal of the American Society of Nephrology : JASN 2008;19(4):685-94.
2007: Ji Ma; Michele Rossini; Hai-Chun Yang; Yiqin Zuo; Agnes B Fogo; Iekuni Ichikawa
Effects of podocyte injury on glomerular development.
Pediatric research 2007;62(4):417-21.
2007: Eisuke Suganuma; Vladimir R Babaev; Masaru Motojima; Yiqin Zuo; Nobuhiko Ayabe; Agnes B Fogo; Iekuni Ichikawa; MacRae F Linton; Sergio Fazio; Valentina Kon
Angiotensin inhibition decreases progression of advanced atherosclerosis and stabilizes established atherosclerotic plaques.
Journal of the American Society of Nephrology : JASN 2007;18(8):2311-9.
2006: Yiqin Zuo; Taiji Matsusaka; Jianyong Zhong; Ji Ma; Li-Jun Ma; Zaher Hanna; Paul Jolicoeur; Agnes B Fogo; Iekuni Ichikawa
HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis.
Journal of the American Society of Nephrology : JASN 2006;17(10):2832-43.
2006: Fumio Niimura; Valentina Kon; Iekuni Ichikawa
The renin-angiotensin system in the development of the congenital anomalies of the kidney and urinary tract.
Current opinion in pediatrics 2006;18(2):161-6.
2006: Yoichi Miyazaki; Hiroyuki Ueda; Takashi Yokoo; Yasunori Utsunomiya; Tetsuya Kawamura; Taiji Matsusaka; Iekuni Ichikawa; Tatsuo Hosoya
Inhibition of endogenous BMP in the glomerulus leads to mesangial matrix expansion.
Biochemical and biophysical research communications 2006;340(2):681-8.
2006: Eisuke Suganuma; Yiqin Zuo; Nobuhiko Ayabe; Ji Ma; Vladimir R Babaev; MacRae F Linton; Sergio Fazio; Iekuni Ichikawa; Agnes B Fogo; Valentina Kon
Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.
Journal of the American Society of Nephrology : JASN 2006;17(2):433-41.
2006: Nobuhiko Ayabe; Vladimir R Babaev; Yiwei Tang; Takakuni Tanizawa; Agnes B Fogo; MacRae F Linton; Iekuni Ichikawa; Sergio Fazio; Valentina Kon
Transiently heightened angiotensin II has distinct effects on atherosclerosis and aneurysm formation in hyperlipidemic mice.
Atherosclerosis 2006;184(2):312-21.
2006: Akira Mori; Noa Uchida; Akifumi Inomo; Shun-ichiro Izumi; Iekuni Ichikawa
Inferior vena cava diameter pulse waveforms in the human fetus: relationship with flow velocity waveform.
Journal of perinatal medicine 2006;34(5):414-9.
2005: Jianyong Zhong; Yiqin Zuo; Ji Ma; Agnes B Fogo; Paul Jolicoeur; Iekuni Ichikawa; Taiji Matsusaka
Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy.
Kidney international 2005;68(3):1048-60.
2005: Takako Asano; Fumio Niimura; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa; Taiji Matsusaka
Permanent genetic tagging of podocytes: fate of injured podocytes in a mouse model of glomerular sclerosis.
Journal of the American Society of Nephrology : JASN 2005;16(8):2257-62.
2005: Takako Asano; Taiji Matsusaka; Shuki Mizutani; Iekuni Ichikawa
Rapid downregulation of beta-actin-based CAG promoter and filamentous actin in injured podocytes.
Journal of medical and dental sciences 2005;52(2):129-34.
2005: Iekuni Ichikawa; Ji Ma; Masaru Motojima; Taiji Matsusaka
Podocyte damage damages podocytes: autonomous vicious cycle that drives local spread of glomerular sclerosis.
Current opinion in nephrology and hypertension 2005;14(3):205-10.
2005: Taiji Matsusaka; Jing Xin; Suguri Niwa; Kazuto Kobayashi; Akira Akatsuka; Hiroomi Hashizume; Qing-Cheng Wang; Ira Pastan; Agnes B Fogo; Iekuni Ichikawa
Genetic engineering of glomerular sclerosis in the mouse via control of onset and severity of podocyte-specific injury.
Journal of the American Society of Nephrology : JASN 2005;16(4):1013-23.
2004: Ayabe Nobuhiko; Eisuke Suganuma; Vladimir R Babaev; Agnes Fogo; Larry L Swift; MacRae F Linton; Sergio Fazio; Iekuni Ichikawa; Valentina Kon
Angiotensin II amplifies macrophage-driven atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(11):2143-8.
2004: Jing Xin; Toshio Homma; Taiji Matsusaka; Ji Ma; Yoshitaka Isaka; Enyu Imai; Iekuni Ichikawa
Suppression of cyclosporine a nephrotoxicity in vivo by transforming growth factor beta receptor-immunoglobulin G chimeric protein.
Transplantation 2004;77(9):1433-42.
2004: Ji Ma; Taiji Matsusaka; Haichun Yang; Hiroshi Kawachi; Fujio Shimizu; Yoshitaka Isaka; Enyu Imai; Valentina Kon; Iekuni Ichikawa
Local actions of endogenous angiotensin II in injured glomeruli.
Journal of the American Society of Nephrology : JASN 2004;15(5):1268-76.
2003: Takako Nakano; Fumio Niimura; Katharina Hohenfellner; Eiji Miyakita; Iekuni Ichikawa
Screening for mutations in BMP4 and FOXC1 genes in congenital anomalies of the kidney and urinary tract in humans.
The Tokai journal of experimental and clinical medicine 2003;28(3):121-6.
2003: Yoichi Miyazaki; Iekuni Ichikawa
Ontogeny of congenital anomalies of the kidney and urinary tract, CAKUT.
Pediatrics international : official journal of the Japan Pediatric Society 2003;45(5):598-604.
2003: Masahiro Nomura; Harumi Kuno-Sakai; Mikio Kimura; Iekuni Ichikawa
Dynamics of transplacental transmission of pertussis antibodies in premature and full-term infants.
The Tokai journal of experimental and clinical medicine 2003;28(1):21-6.
2003: Yoichi Miyazaki; Keisuke Oshima; Agnes Fogo; Iekuni Ichikawa
Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development.
Kidney international 2003;63(3):835-44.
2002: Masashi Nishida; Hidehiko Fujinaka; Taiji Matsusaka; James Price; Valentina Kon; Agnes B Fogo; Jeffrey M Davidson; MacRae F Linton; Sergio Fazio; Toshio Homma; Hiroaki Yoshida; Iekuni Ichikawa
Absence of angiotensin II type 1 receptor in bone marrow-derived cells is detrimental in the evolution of renal fibrosis.
The Journal of clinical investigation 2002;110(12):1859-68.
2002: Hiroaki Yoshida; Iekuni Ichikawa
[History of nephrology in the past 100 years: Significance of hyperfiltration theory in the nephrology].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 2002;91(5):1405-8.
2002: Iekuni Ichikawa; Fumiyo Kuwayama; John C Pope; F Douglas Stephens; Yoichi Miyazaki
Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT.
Kidney international 2002;61(3):889-98.
2002: Fumiyo Kuwayama; Yoichi Miyazaki; Iekuni Ichikawa
Embryogenesis of the congenital anomalies of the kidney and the urinary tract.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2002;17 Suppl 9():45-7.
2002: Taiji Matsusaka; Yoichi Miyazaki; Iekuni Ichikawa
The renin angiotensin system and kidney development.
Annual review of physiology 2002;64():551-61.
2001: J Takaya; Taiji Matsusaka; H Katori; M Tamura; Yoichi Miyazaki; Toshio Homma; Iekuni Ichikawa
In situ demonstration of angiotensin-dependent and independent pathways for hyperaldosteronism during chronic extracellular fluid volume depletion.
Molecular endocrinology (Baltimore, Md.) 2001;15(12):2229-35.
2001: K Oshima; Yoichi Miyazaki; John W Brock; Mark C Adams; Iekuni Ichikawa; John C Pope
Angiotensin type II receptor expression and ureteral budding.
The Journal of urology 2001;166(5):1848-52.
2001: Fumiyo Kuwayama; Y Hamasaki; Tsuyoshi Shinagawa; Chidori Kubota; Iekuni Ichikawa; Y Kato; S Oi; Osamu Shinohara
Moyamoya disease complicated with renal artery stenosis and nephrotic syndrome: reversal of nephrotic syndrome after nephrectomy.
The Journal of pediatrics 2001;138(3):418-20.
2001: Yoichi Miyazaki; Iekuni Ichikawa
Role of the angiotensin receptor in the development of the mammalian kidney and urinary tract.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2001;128(1):89-97.
2001: John C Pope; John W Brock; Mark C Adams; Yoichi Miyazaki; F Douglas Stephens; Iekuni Ichikawa
Congenital anomalies of the kidney and urinary tract--role of the loss of function mutation in the pluripotent angiotensin type 2 receptor gene.
The Journal of urology 2001;165(1):196-202.
2001: Yoichi Miyazaki; Iekuni Ichikawa
Nephrotoxicity of angiotensin inhibition during the perinatal period.
Experimental nephrology 2001;9(1):10-3.
2000: H Fujinaka; Yoichi Miyazaki; Taiji Matsusaka; H Yoshida; Agnes B Fogo; Tadashi Inagami; Iekuni Ichikawa
Salutary role for angiotensin in partial urinary tract obstruction.
Kidney international 2000;58(5):2018-27.
2000: Valentina Kon; Iekuni Ichikawa
Prospects for gene transfer into renal cells.
Kidney international 2000;57(5):2169-70.
2000: Yoichi Miyazaki; K Oshima; Agnes Fogo; Brigid L M Hogan; Iekuni Ichikawa
Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter.
The Journal of clinical investigation 2000;105(7):863-73.
2000: Taiji Matsusaka; Valentina Kon; J Takaya; H Katori; X Chen; J Miyazaki; Toshio Homma; Agnes Fogo; Iekuni Ichikawa
Dual renin gene targeting by Cre-mediated interchromosomal recombination.
Genomics 2000;64(2):127-31.
2000: Taiji Matsusaka; H Katori; Yoichi Miyazaki; Fumio Niimura; Iekuni Ichikawa
Angiotensin II as a player in fibrosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2000;15 Suppl 6():64-5.
1999: Taiji Matsusaka; H Katori; T Homma; Iekuni Ichikawa
Mechanism of cardiac fibrosis by angiotensin. New insight revealed by genetic engineering.
Trends in cardiovascular medicine 1999;9(7):180-4.
1999: John C Pope; John W Brock; Mark C Adams; F Douglas Stephens; Iekuni Ichikawa
How they begin and how they end: classic and new theories for the development and deterioration of congenital anomalies of the kidney and urinary tract, CAKUT.
Journal of the American Society of Nephrology : JASN 1999;10(9):2018-28.
1999: S Tsuchida; Yoichi Miyazaki; Taiji Matsusaka; Tracy E Hunley; Tadashi Inagami; Agnes Fogo; Iekuni Ichikawa
Potent antihypertrophic effect of the bradykinin B2 receptor system on the renal vasculature.
Kidney international 1999;56(2):509-16.
1999: Taiji Matsusaka; H Katori; Tadashi Inagami; Agnes Fogo; Iekuni Ichikawa
Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice.
The Journal of clinical investigation 1999;103(10):1451-8.
1999: Yoichi Miyazaki; S Tsuchida; Agnes Fogo; Iekuni Ichikawa
The renal lesions that develop in neonatal mice during angiotensin inhibition mimic obstructive nephropathy.
Kidney international 1999;55(5):1683-95.
1999: H Nishimura; Elizabeth B Yerkes; Katharina Hohenfellner; Yoichi Miyazaki; J Ma; Tracy E Hunley; H Yoshida; Toshihiro Ichiki; David Threadgill; John A Phillips; B M Hogan; Agnes Fogo; John W Brock; Tadashi Inagami; Iekuni Ichikawa
Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men.
Molecular cell 1999;3(1):1-10.
1998: Yoichi Miyazaki; S Tsuchida; H Nishimura; John C Pope; Raymond C Harris; J M McKanna; Tadashi Inagami; Brigid L M Hogan; Agnes Fogo; Iekuni Ichikawa
Angiotensin induces the urinary peristaltic machinery during the perinatal period.
The Journal of clinical investigation 1998;102(8):1489-97.
1998: Elizabeth B Yerkes; H Nishimura; Yoichi Miyazaki; S Tsuchida; John W Brock; Iekuni Ichikawa
Role of angiotensin in the congenital anomalies of the kidney and urinary tract in the mouse and the human.
Kidney international. Supplement 1998;67():S75-7.
1998: Ji Ma; H Nishimura; Agnes Fogo; Valentina Kon; Tadashi Inagami; Iekuni Ichikawa
Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction.
Kidney international 1998;53(4):937-44.
1998: S Okubo; Fumio Niimura; Taiji Matsusaka; Agnes Fogo; B L Hogan; Iekuni Ichikawa
Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption.
Kidney international 1998;53(3):617-25.
1998: S Tsuchida; Taiji Matsusaka; X Chen; S Okubo; Fumio Niimura; H Nishimura; Agnes Fogo; H Utsunomiya; Tadashi Inagami; Iekuni Ichikawa
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.
The Journal of clinical investigation 1998;101(4):755-60.
1998: John C Pope; H Nishimura; Iekuni Ichikawa
Role of angiotensin in the development of the kidney and urinary tract.
Néphrologie 1998;19(7):433-6.
1997: S Okubo; Iekuni Ichikawa
Role of angiotensin: insight from gene targeting studies.
Kidney international. Supplement 1997;63():S7-9.
1997: Taiji Matsusaka; Agnes Fogo; Iekuni Ichikawa
Targeting the genes of angiotensin receptors.
Seminars in nephrology 1997;17(5):396-403.
1997: H Nishimura; Taiji Matsusaka; Agnes Fogo; Valentina Kon; Iekuni Ichikawa
A novel in vivo mechanism for angiotensin type 1 receptor regulation.
Kidney international 1997;52(2):345-55.
1997: T Matsusaka; Iekuni Ichikawa
Gene targeting in nephrology.
Experimental nephrology 1997;5(2):168-73.
1997: X Chen; W Li; H Yoshida; S Tsuchida; H Nishimura; F Takemoto; S Okubo; Agnes Fogo; Taiji Matsusaka; Iekuni Ichikawa
Targeting deletion of angiotensin type 1B receptor gene in the mouse.
The American journal of physiology 1997;272(3 Pt 2):F299-304.
1997: S Okubo; Fumio Niimura; H Nishimura; F Takemoto; Agnes Fogo; Taiji Matsusaka; Iekuni Ichikawa
Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion.
The Journal of clinical investigation 1997;99(5):855-60.
1997: Taiji Matsusaka; Iekuni Ichikawa
Biological functions of angiotensin and its receptors.
Annual review of physiology 1997;59():395-412.
1997: Fumio Niimura; S Okubo; Agnes Fogo; Iekuni Ichikawa
Temporal and spatial expression pattern of the angiotensinogen gene in mice and rats.
The American journal of physiology 1997;272(1 Pt 2):R142-7.
1996: Taiji Matsusaka; H Nishimura; H Utsunomiya; J Kakuchi; Fumio Niimura; Tadashi Inagami; A Fogo; Iekuni Ichikawa
Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells.
The Journal of clinical investigation 1996;98(8):1867-77.
1996: Iekuni Ichikawa
Will angiotensin II receptor antagonists be renoprotective in humans?
Kidney international 1996;50(2):684-92.
1996: Iekuni Ichikawa; A Fogo
Focal segmental glomerulosclerosis.
Pediatric nephrology (Berlin, Germany) 1996;10(3):374-91.
1996: Tracy E Hunley; B A Julian; John A Phillips; Marshall Summar; H Yoshida; R G Horn; Nancy Brown; A Fogo; Iekuni Ichikawa; Valentina Kon
Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in IgA nephropathy.
Kidney international 1996;49(2):571-7.
1996: Fumio Niimura; Taiji Matsusaka; Iekuni Ichikawa
Evidence for the role of angiotensin in the establishment and maintenance of renal morphology.
Contributions to nephrology 1996;118():234-7.
1995: T Ichiki; Patricia A Labosky; Chiyo Shiota; Shigeru Okuyama; Y Imagawa; A Fogo; Fumio Niimura; Iekuni Ichikawa; Brigid L M Hogan; Tadashi Inagami
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor.
Nature 1995;377(6551):748-50.
1995: S Kiyama; T Yoshioka; I M Burr; Valentina Kon; A Fogo; Iekuni Ichikawa
Strategic locus for the activation of the superoxide dismutase gene in the nephron.
Kidney international 1995;47(2):536-46.
1995: J Kakuchi; T Ichiki; S Kiyama; Brigid L M Hogan; A Fogo; Tadashi Inagami; Iekuni Ichikawa
Developmental expression of renal angiotensin II receptor genes in the mouse.
Kidney international 1995;47(1):140-7.
1994: H Yoshida; J Kakuchi; N Yoshikawa; T Saruta; Tadashi Inagami; John A Phillips; Iekuni Ichikawa
Angiotensin II type 1 receptor gene abnormality in a patient with Bartter's syndrome.
Kidney international 1994;46(6):1505-9.
1994: T Yoshioka; T Homma; Barbara Meyrick; M Takeda; T Moore-Jarrett; Valentina Kon; Iekuni Ichikawa
Oxidants induce transcriptional activation of manganese superoxide dismutase in glomerular cells.
Kidney international 1994;46(2):405-13.
1994: R Tanaka; Valentina Kon; T Yoshioka; Iekuni Ichikawa; A Fogo
Angiotensin converting enzyme inhibitor modulates glomerular function and structure by distinct mechanisms.
Kidney international 1994;45(2):537-43.
1994: T Yoshioka; T Kawamura; Barbara Meyrick; J K Beckman; R L Hoover; H Yoshida; Iekuni Ichikawa
Induction of manganese superoxide dismutase by glucocorticoids in glomerular cells.
Kidney international 1994;45(1):211-9.
1993: Valentina Kon; A Fogo; Iekuni Ichikawa
Bradykinin causes selective efferent arteriolar dilation during angiotensin I converting enzyme inhibition.
Kidney international 1993;44(3):545-50.
1993: Y Kakinuma; A Fogo; Tadashi Inagami; Iekuni Ichikawa
Intrarenal localization of angiotensin II type 1 receptor mRNA in the rat.
Kidney international 1993;43(6):1229-35.
1993: M Takeda; T Homma; Matthew D Breyer; N Horiba; R L Hoover; S Kawamoto; Iekuni Ichikawa; Valentina Kon
Volume and agonist-induced regulation of myosin light-chain phosphorylation in glomerular mesangial cells.
The American journal of physiology 1993;264(3 Pt 2):F421-6.
1992: Midori Awazu; A Yared; Larry L Swift; R L Hoover; Iekuni Ichikawa
Dietary fatty acid modulates glomerular atrial natriuretic peptide receptor.
Kidney international 1992;42(2):265-71.
1992: H Yoshida; J Kakuchi; D F Guo; H Furuta; N Iwai; R van der Meer-de Jong; Tadashi Inagami; Iekuni Ichikawa
Analysis of the evolution of angiotensin II type 1 receptor gene in mammals (mouse, rat, bovine and human).
Biochemical and biophysical research communications 1992;186(2):1042-9.
1992: Y Kakinuma; T Kawamura; T Bills; T Yoshioka; Iekuni Ichikawa; A Fogo
Blood pressure-independent effect of angiotensin inhibition on vascular lesions of chronic renal failure.
Kidney international 1992;42(1):46-55.
1991: M Hiraoka-Yoshimoto; K Higashida; M Takeda; S Kawamoto; Iekuni Ichikawa; R L Hoover
Characterization of myosin heavy and light chains in cultured mesangial cells.
Kidney international 1991;40(6):1013-9.
1991: T Yoshioka; Iekuni Ichikawa; A Fogo
Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality.
Journal of the American Society of Nephrology : JASN 1991;2(4):902-12.
1991: M Motojima; F Nishijima; M Ikoma; T Kawamura; T Yoshioka; A B Fogo; T Sakai; Iekuni Ichikawa
Role for "uremic toxin" in the progressive loss of intact nephrons in chronic renal failure.
Kidney international 1991;40(3):461-9.
1991: T Kawamura; T Yoshioka; T Bills; A Fogo; Iekuni Ichikawa
Glucocorticoid activates glomerular antioxidant enzymes and protects glomeruli from oxidant injuries.
Kidney international 1991;40(2):291-301.
1991: M Ikoma; T Kawamura; Y Kakinuma; A Fogo; Iekuni Ichikawa
Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitor on glomerular lesions.
Kidney international 1991;40(2):195-202.
1991: Midori Awazu; Valentina Kon; Raymond C Harris; T Imada; Tadashi Inagami; Iekuni Ichikawa
Renal sympathetic nerves modulate glomerular ANP receptors and filtration.
The American journal of physiology 1991;261(1 Pt 2):F29-35.
1991: A Fogo; Iekuni Ichikawa
Evidence for a pathogenic linkage between glomerular hypertrophy and sclerosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1991;17(6):666-9.
1991: A Fogo; Iekuni Ichikawa
Angiogenic action of angiotensin II is important for the glomerular growth of maturing kidneys.
Kidney international. Supplement 1991;32():S37-8.
1991: Midori Awazu; M Sugiura; Tadashi Inagami; Iekuni Ichikawa; Valentina Kon
Cyclosporine promotes glomerular endothelin binding in vivo.
Journal of the American Society of Nephrology : JASN 1991;1(11):1253-8.
1991: Iekuni Ichikawa; M Ikoma; A Fogo
Glomerular growth promoters, the common key mediator for progressive glomerular sclerosis in chronic renal diseases.
Advances in nephrology from the Necker Hospital 1991;20():127-48.
1991: A Fogo; M Ikoma; Y Yoshida; Iekuni Ichikawa
Studies for pronounced susceptibility of deep nephrons to glomerular sclerosis in young animals.
Contributions to nephrology 1991;95():126-30.
1991: Y Yoshida; M Ikoma; T Kawamura; A Fogo; Iekuni Ichikawa
Internephron heterogeneity in susceptibility to glomerular sclerosis and responsiveness to therapeutic measures.
Contributions to nephrology 1991;95():107-11.
1991: Midori Awazu; R E Parker; B R Harvie; Iekuni Ichikawa; Valentina Kon
Down-regulation of endothelin-1 receptors by protein kinase C in streptozotocin diabetic rats.
Journal of cardiovascular pharmacology 1991;17 Suppl 7():S500-2.
1990: A Fogo; Y Yoshida; A Yared; Iekuni Ichikawa
Importance of angiogenic action of angiotensin II in the glomerular growth of maturing kidneys.
Kidney international 1990;38(6):1068-74.
1990: Iekuni Ichikawa; T Yoshioka; A Fogo; Valentina Kon
Role of angiotensin II in altered glomerular hemodynamics in congestive heart failure.
Kidney international. Supplement 1990;30():S123-6.
1990: M Ikoma; T Yoshioka; Iekuni Ichikawa; A Fogo
Mechanism of the unique susceptibility of deep cortical glomeruli of maturing kidneys to severe focal glomerular sclerosis.
Pediatric research 1990;28(3):270-6.
1990: T Yoshioka; T Bills; T Moore-Jarrett; H L Greene; I M Burr; Iekuni Ichikawa
Role of intrinsic antioxidant enzymes in renal oxidant injury.
Kidney international 1990;38(2):282-8.
1990: A Fogo; Edith P Hawkins; PL Berry; A D Glick; M L Chiang; R C MacDonell; Iekuni Ichikawa
Glomerular hypertrophy in minimal change disease predicts subsequent progression to focal glomerular sclerosis.
Kidney international 1990;38(1):115-23.
1990: Valentina Kon; Iekuni Ichikawa
What is the cause of sodium retention in acute nephritis?
Pediatric nephrology (Berlin, Germany) 1990;4(4):307.
1990: Valentina Kon; M Sugiura; Tadashi Inagami; B R Harvie; Iekuni Ichikawa; R L Hoover
Role of endothelin in cyclosporine-induced glomerular dysfunction.
Kidney international 1990;37(6):1487-91.
1990: Valentina Kon; Raymond C Harris; Iekuni Ichikawa
A regulatory role for large vessels in organ circulation. Endothelial cells of the main renal artery modulate intrarenal hemodynamics in the rat.
The Journal of clinical investigation 1990;85(6):1728-33.
1989: A Fogo; Iekuni Ichikawa
Evidence for the central role of glomerular growth promoters in the development of sclerosis.
Seminars in nephrology 1989;9(4):329-42.
1989: Y Yoshida; T Kawamura; M Ikoma; A Fogo; Iekuni Ichikawa
Effects of antihypertensive drugs on glomerular morphology.
Kidney international 1989;36(4):626-35.
1989: Midori Awazu; T Imada; Valentina Kon; Tadashi Inagami; Iekuni Ichikawa
Role of endogenous atrial natriuretic peptide in congestive heart failure.
The American journal of physiology 1989;257(3 Pt 2):R641-6.
1989: T Yoshioka; Iekuni Ichikawa
Glomerular dysfunction induced by polymorphonuclear leukocyte-derived reactive oxygen species.
The American journal of physiology 1989;257(1 Pt 2):F53-9.
1989: Valentina Kon; T Yoshioka; A Fogo; Iekuni Ichikawa
Glomerular actions of endothelin in vivo.
The Journal of clinical investigation 1989;83(5):1762-7.
1989: T Yoshioka; A Yared; Valentina Kon; Iekuni Ichikawa
Impaired preservation of GFR during hypotension in preexistent renal hypoperfusion.
The American journal of physiology 1989;256(2 Pt 2):F314-20.
1989: Y Yoshida; A Fogo; Iekuni Ichikawa
Glomerular hemodynamic changes vs. hypertrophy in experimental glomerular sclerosis.
Kidney international 1989;35(2):654-60.
1989: Midori Awazu; A Y Barakat; R L Chevalier; Iekuni Ichikawa
The cause of uremia in obstructed kidneys.
The Journal of pediatrics 1989;114(2):179-86.
1988: Iekuni Ichikawa; Y Yoshida; A Fogo; M L Purkerson; S Klahr
Effect of heparin on the glomerular structure and function of remnant nephrons.
Kidney international 1988;34(5):638-44.
1988: T Yoshioka; H Shiraga; Y Yoshida; A Fogo; A D Glick; W M Deen; JR Hoyer; Iekuni Ichikawa
"Intact nephrons" as the primary origin of proteinuria in chronic renal disease. Study in the rat model of subtotal nephrectomy.
The Journal of clinical investigation 1988;82(5):1614-23.
1988: A Fogo; Y Yoshida; A D Glick; T Homma; Iekuni Ichikawa
Serial micropuncture analysis of glomerular function in two rat models of glomerular sclerosis.
The Journal of clinical investigation 1988;82(1):322-30.
1988: KAMAL BADR; G F Schreiner; M Wasserman; Iekuni Ichikawa
Preservation of the glomerular capillary ultrafiltration coefficient during rat nephrotoxic serum nephritis by a specific leukotriene D4 receptor antagonist.
The Journal of clinical investigation 1988;81(6):1702-9.
1988: Y Yoshida; A Fogo; H Shiraga; A D Glick; Iekuni Ichikawa
Serial micropuncture analysis of single nephron function in subtotal renal ablation.
Kidney international 1988;33(4):855-67.
1988: A Yared; H Miyazawa; M L Purkerson; S Klahr; D J Salant; Iekuni Ichikawa
Effect of diet, age and sex on the renal response to immune injury in the rat.
Kidney international 1988;33(2):561-70.
1987: T Yoshioka; H G Rennke; D J Salant; W M Deen; Iekuni Ichikawa
Role of abnormally high transmural pressure in the permselectivity defect of glomerular capillary wall: a study in early passive Heymann nephritis.
Circulation research 1987;61(4):531-8.
1987: KAMAL BADR; B M Brenner; Iekuni Ichikawa
Glomerular microcirculatory actions of leukotriene D4 in the rat: implications for glomerulonephritis.
Advances in prostaglandin, thromboxane, and leukotriene research 1987;17B():741-3.
1985: Valentina Kon; A Yared; Iekuni Ichikawa
Role of renal sympathetic nerves in mediating hypoperfusion of renal cortical microcirculation in experimental congestive heart failure and acute extracellular fluid volume depletion.
The Journal of clinical investigation 1985;76(5):1913-20.
1985: A Yared; Valentina Kon; Iekuni Ichikawa
Mechanism of preservation of glomerular perfusion and filtration during acute extracellular fluid volume depletion. Importance of intrarenal vasopressin-prostaglandin interaction for protecting kidneys from constrictor action of vasopressin.
The Journal of clinical investigation 1985;75(5):1477-87.