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Toshihiro Ichiki

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TOP 3
Toshihiro Ichiki
Regulation of Angiotensin II Receptor Expression.
Toshiro Saito; Kenji Sunagawa; Mayumi Hirano; Toshihiro Ichiki; Tomomi Ide; Noriyuki Koibuchi; Katsuya Hirano
Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.
Toshihiro Ichiki; Aya Kamiharaguchi; Shiro Kitamoto; Hirohide Matsuura; Ryohei Miyazaki; Toru Hashimoto; Tomotake Tokunou; Kenji Sunagawa
Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells.

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All Publications

2013: Toshihiro Ichiki
Regulation of Angiotensin II Receptor Expression.
Current pharmaceutical design 2013;19(17):3013-21.
2013: Toshiro Saito; Kenji Sunagawa; Mayumi Hirano; Toshihiro Ichiki; Tomomi Ide; Noriyuki Koibuchi; Katsuya Hirano
Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility.
Circulation 2013;127(1):104-14.
2012: Toshihiro Ichiki; Aya Kamiharaguchi; Shiro Kitamoto; Hirohide Matsuura; Ryohei Miyazaki; Toru Hashimoto; Tomotake Tokunou; Kenji Sunagawa
Resveratrol attenuates angiotensin II-induced senescence of vascular smooth muscle cells.
Regulatory peptides 2012;177(1-3):35-9.
2012: Ryohei Miyazaki; Eriko Narabayashi; Kotaro Takeda; Toru Hashimoto; Toshihiro Ichiki; Jiro Ikeda; Aya Kamiharaguchi; Hirohide Matsuura; Kenji Sunagawa
Acetylcholinesterase inhibitors attenuate angiogenesis.
Clinical science (London, England : 1979) 2012;123(4):241-9.
2012: Eriko Inoue; Aya Kamiharaguchi; Hirohide Matsuura; Toru Hashimoto; Toshihiro Ichiki; Jiro Ikeda; Kotaro Takeda; Kenji Sunagawa
Beraprost sodium, a stable prostacyclin analogue, improves insulin resistance in high-fat diet-induced obese mice.
The Journal of endocrinology 2012;213(3):285-91.
2011: Hirohide Matsuura; Ryohei Miyazaki; Eriko Narabayashi; Toru Hashimoto; Toshihiro Ichiki; Jiro Ikeda; Shiro Kitamoto; Kotaro Takeda; Tomotake Tokunou; Kenji Sunagawa
Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor.
Hypertension 2011;58(3):386-93.
2011: Toru Hashimoto; Toshihiro Ichiki; Jiro Ikeda; Keita Inanaga; Hirohide Matsuura; Ryohei Miyazaki; Eriko Narabayashi; Kotaro Takeda; Kenji Sunagawa
Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation.
Cardiovascular research 2011;91(4):711-9.
2011: Toshihiro Ichiki
Collaboration between smokers and tobacco in endothelial dysfunction.
Cardiovascular research 2011;90(3):395-6.
2010: Keita Inanaga; Toshihiro Ichiki; Ryohei Miyazaki; Kotaro Takeda; Toru Hashimoto; Hirohide Matsuura; Kenji Sunagawa
Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice.
Atherosclerosis 2010;213(1):52-8.
2010: Toshihiro Ichiki
Perivascular adipose tissue, a Janus-faced regulator of vascular function.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(7):1300-1.
2010: Toshihiro Ichiki
Thyroid hormone and atherosclerosis.
Vascular pharmacology 2010;52(3-4):151-6.
2009: Kotaro Takeda; Toshihiro Ichiki; Eriko Narabayashi; Keita Inanaga; Ryohei Miyazaki; Toru Hashimoto; Hirohide Matsuura; Jiro Ikeda; Toshio Miyata; Kenji Sunagawa
Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(12):2132-7.
2009: Keita Inanaga; Toshihiro Ichiki; Hirohide Matsuura; Ryohei Miyazaki; Toru Hashimoto; Kotaro Takeda; Kenji Sunagawa
Resveratrol attenuates angiotensin II-induced interleukin-6 expression and perivascular fibrosis.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(6):466-71.
2009: Qingping Tian; Ryohei Miyazaki; Toshihiro Ichiki; Ikuyo Imayama; Keita Inanaga; Hideki Ohtsubo; Kotaro Yano; Kotaro Takeda; Kenji Sunagawa
Inhibition of tumor necrosis factor-alpha-induced interleukin-6 expression by telmisartan through cross-talk of peroxisome proliferator-activated receptor-gamma with nuclear factor kappaB and CCAAT/enhancer-binding protein-beta.
Hypertension 2009;53(5):798-804.
2008: Ryohei Miyazaki; Toshihiro Ichiki; Toru Hashimoto; Keita Inanaga; Ikuyo Imayama; Junichi Sadoshima; Kenji Sunagawa
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1263-9.
2008: Ikuyo Imayama; Toshihiro Ichiki; Dan Patton; Keita Inanaga; Ryohei Miyazaki; Hideki Ohtsubo; Qingping Tian; Kotaro Yano; Kenji Sunagawa
Liver X receptor activator downregulates angiotensin II type 1 receptor expression through dephosphorylation of Sp1.
Hypertension 2008;51(6):1631-6.
2008: Hideki Ohtsubo; Toshihiro Ichiki; Ikuyo Imayama; Hiroki Ono; Kae Fukuyama; Yasuko Hashiguchi; Junichi Sadoshima; Kenji Sunagawa
Involvement of Mst1 in tumor necrosis factor-alpha-induced apoptosis of endothelial cells.
Biochemical and biophysical research communications 2008;367(2):474-80.
2007: Ming Chen; Toshihiro Ichiki; Hideki Ohtsubo; Ikuyo Imayama; Keita Inanaga; Ryouhei Miyazaki; Kenji Sunagawa
Inhibition of balloon injury-induced neointimal formation by olmesartan and pravastatin in rats with insulin resistance.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(10):971-8.
2007: Hideki Ohtsubo; Toshihiro Ichiki; Ryohei Miyazaki; Keita Inanaga; Ikuyo Imayama; Yasuko Hashiguchi; Junichi Sadoshima; Kenji Sunagawa
Inducible cAMP early repressor inhibits growth of vascular smooth muscle cell.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(7):1549-55.
2006: Ikuyo Imayama; Toshihiro Ichiki; Keita Inanaga; Hideki Ohtsubo; Kae Fukuyama; Hiroki Ono; Yasuko Hashiguchi; Kenji Sunagawa
Telmisartan downregulates angiotensin II type 1 receptor through activation of peroxisome proliferator-activated receptor gamma.
Cardiovascular research 2006;72(1):184-90.
2006: Kae Fukuyama; Toshihiro Ichiki; Ikuyo Imayama; Hideki Ohtsubo; Hiroki Ono; Yasuko Hashiguchi; Akira Takeshita; Kenji Sunagawa
Thyroid hormone inhibits vascular remodeling through suppression of cAMP response element binding protein activity.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(9):2049-55.
2006: Toshihiro Ichiki
Role of cAMP response element binding protein in cardiovascular remodeling: good, bad, or both?
Arteriosclerosis, thrombosis, and vascular biology 2006;26(3):449-55.
2006: Hiroki Ono; Toshihiro Ichiki; Hideki Ohtsubo; Kae Fukuyama; Ikuyo Imayama; Naoko Iino; Satoko Masuda; Yasuko Hashiguchi; Akira Takeshita; Kenji Sunagawa
CAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular cell adhesion molecule-1 expression in endothelial cells.
Hypertension research : official journal of the Japanese Society of Hypertension 2006;29(1):39-47.
2005: Kae Fukuyama; Toshihiro Ichiki; Hiroki Ono; Tomotake Tokunou; Naoko Iino; Satoko Masuda; Hideki Ohtsubo; Akira Takeshita
cAMP-response element-binding protein mediates prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells.
Biochemical and biophysical research communications 2005;338(2):910-8.
2005: Hiroki Ono; Toshihiro Ichiki; Hideki Ohtsubo; Kae Fukuyama; Ikuyo Imayama; Yasuko Hashiguchi; Junichi Sadoshima; Kenji Sunagawa
Critical role of Mst1 in vascular remodeling after injury.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(9):1871-6.
2005: Toshihiro Ichiki
[Tissue distribution and regulatory mechanism of angiotensin II receptor expression].
Nihon rinsho. Japanese journal of clinical medicine 2005;63 Suppl 3():36-41.
2005: Junko Hiroki; Hiroaki Shimokawa; Yasushi Mukai; Toshihiro Ichiki; Akira Takeshita
Divergent effects of estrogen and nicotine on Rho-kinase expression in human coronary vascular smooth muscle cells.
Biochemical and biophysical research communications 2005;326(1):154-9.
2004: Toshihiro Ichiki; Tomotake Tokunou; Kae Fukuyama; Naoko Iino; Satoko Masuda; Akira Takeshita
15-Deoxy-Delta12,14-prostaglandin J2 and thiazolidinediones transactivate epidermal growth factor and platelet-derived growth factor receptors in vascular smooth muscle cells.
Biochemical and biophysical research communications 2004;323(2):402-8.
2004: Hiroki Ono; Toshihiro Ichiki; Kae Fukuyama; Naoko Iino; Satoko Masuda; Kensuke Egashira; Akira Takeshita
cAMP-response element-binding protein mediates tumor necrosis factor-alpha-induced vascular smooth muscle cell migration.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(9):1634-9.
2004: Junko Hiroki; Hiroaki Shimokawa; Midoriko Higashi; Keiko Morikawa; Tadashi Kandabashi; Natsumi Kawamura; Toru Kubota; Toshihiro Ichiki; Mutsuki Amano; Kozo Kaibuchi; Akira Takeshita
Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells.
Journal of molecular and cellular cardiology 2004;37(2):537-46.
2004: Ken-ichi Hiasa; Minako Ishibashi; Kisho Ohtani; Shujiro Inoue; Qingwei Zhao; Shiro Kitamoto; Masataka Sata; Toshihiro Ichiki; Akira Takeshita; Kensuke Egashira
Gene transfer of stromal cell-derived factor-1alpha enhances ischemic vasculogenesis and angiogenesis via vascular endothelial growth factor/endothelial nitric oxide synthase-related pathway: next-generation chemokine therapy for therapeutic neovascularization.
Circulation 2004;109(20):2454-61.
2003: Midoriko Higashi; Hiroaki Shimokawa; Tsuyoshi Hattori; Junko Hiroki; Yasushi Mukai; Keiko Morikawa; Toshihiro Ichiki; Shosuke Takahashi; Akira Takeshita
Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system.
Circulation research 2003;93(8):767-75.
2003: Tomotake Tokunou; Rei Shibata; Hisashi Kai; Toshihiro Ichiki; Takashi Morisaki; Kae Fukuyama; Hiroki Ono; Naoko Iino; Satoko Masuda; Hiroaki Shimokawa; Kensuke Egashira; Tsutomu Imaizumi; Akira Takeshita
Apoptosis induced by inhibition of cyclic AMP response element-binding protein in vascular smooth muscle cells.
Circulation 2003;108(10):1246-52.
2003: Koji Ito; Toshihiro Ichiki; Keiji Ohi; Kensuke Egashira; Mituhiko Ohta; Kenichi Taguchi; Akira Takeshita
Pulmonary capillary hemangiomatosis with severe pulmonary hypertension.
Circulation journal : official journal of the Japanese Circulation Society 2003;67(9):793-5.
2003: Toshihiro Ichiki; Tomotake Tokunou; Kae Fukuyama; Naoko Iino; Satoko Masuda; Akira Takeshita
Cyclic AMP response element-binding protein mediates reactive oxygen species-induced c-fos expression.
Hypertension 2003;42(2):177-83.
2003: Masahiro Mohri; Toshihiro Ichiki; Takeshi Kuga; Akira Takeshita
Evidence for anti-ischemic effect of dual-chamber pacing in patients with the obstructive form of hypertrophic cardiomyopathy.
Japanese heart journal 2003;44(4):587-92.
2003: Kae Fukuyama; Toshihiro Ichiki; Kotaro Takeda; Tomotake Tokunou; Naoko Iino; Satoko Masuda; Minako Ishibashi; Kensuke Egashira; Hiroaki Shimokawa; Katsuya Hirano; Hideo Kanaide; Akira Takeshita
Downregulation of vascular angiotensin II type 1 receptor by thyroid hormone.
Hypertension 2003;41(3):598-603.
2002: Minako Ishibashi; Kensuke Egashira; Ken-ichi Hiasa; Shujiro Inoue; Weihua Ni; Qingwei Zhao; Makoto Usui; Shiro Kitamoto; Toshihiro Ichiki; Akira Takeshita
Antiinflammatory and antiarteriosclerotic effects of pioglitazone.
Hypertension 2002;40(5):687-93.
2002: Toshihiro Ichiki
[Role of Rho/Rho-kinase pathway in angiotensin II signaling].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(10):1929-34.
2002: Kensuke Egashira; Qingwei Zhao; Chu Kataoka; Kisho Ohtani; Makoto Usui; Israel F Charo; Ken-Ichi Nishida; Shujiro Inoue; Makoto Katoh; Toshihiro Ichiki; Akira Takeshita
Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys.
Circulation research 2002;90(11):1167-72.
2002: Yuko Funakoshi; Toshihiro Ichiki; Kotaro Takeda; Tomotake Tokuno; Naoko Iino; Akira Takeshita
Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells.
The Journal of biological chemistry 2002;277(21):18710-7.
2002: Masahiro Mohri; Toshihiro Ichiki; Yoshitaka Hirooka; Akira Takeshita
Endogenous nitric oxide prevents myocardial ischemia in patients with hypertension and left ventricular hypertrophy.
American heart journal 2002;143(4):684-9.
2002: Qingwei Zhao; Kensuke Egashira; Shujiro Inoue; Makoto Usui; Shiro Kitamoto; Weihua Ni; Minako Ishibashi; Ken-ichi Hiasa Ki; Toshihiro Ichiki; Masabumi Shibuya; Akira Takeshita
Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis.
Circulation 2002;105(9):1110-5.
2001: Kiyoshi Takeda; Toshihiro Ichiki; Tomotake Tokunou; Naoko Iino; Akira Takeshita
15-Deoxy-delta 12,14-prostaglandin J2 and thiazolidinediones activate the MEK/ERK pathway through phosphatidylinositol 3-kinase in vascular smooth muscle cells.
The Journal of biological chemistry 2001;276(52):48950-5.
2001: Toshihiro Ichiki; Kiyoshi Takeda; Tomotake Tokunou; Naoko Iino; Kensuke Egashira; Hiroaki Shimokawa; Katsuya Hirano; Hideo Kanaide; Akira Takeshita
Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(12):1896-901.
2001: Tomotake Tokunou; Toshihiro Ichiki; Kiyoshi Takeda; Yuko Funakoshi; Naoko Iino; Akira Takeshita
cAMP response element-binding protein mediates thrombin-induced proliferation of vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1764-9.
2001: Tomotake Tokunou; Toshihiro Ichiki; Kiyoshi Takeda; Yuko Funakoshi; Naoko Iino; Hiroaki Shimokawa; Kensuke Egashira; Akira Takeshita
Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(11):1759-63.
2001: Yuko Funakoshi; Toshihiro Ichiki; Hiroaki Shimokawa; Kensuke Egashira; Kiyoshi Takeda; Kozo Kaibuchi; M Takeya; T Yoshimura; Akira Takeshita
Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells.
Hypertension 2001;38(1):100-4.
2001: Kiyoshi Takeda; Toshihiro Ichiki; Tomotake Tokunou; Naoko Iino; S Fujii; A Kitabatake; Hiroaki Shimokawa; Akira Takeshita
Critical role of Rho-kinase and MEK/ERK pathways for angiotensin II-induced plasminogen activator inhibitor type-1 gene expression.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(5):868-73.
2001: Toshihiro Ichiki; Kiyoshi Takeda; Tomotake Tokunou; Yuko Funakoshi; Koji Ito; Naoko Iino; Akira Takeshita
Reactive oxygen species-mediated homologous downregulation of angiotensin II type 1 receptor mRNA by angiotensin II.
Hypertension 2001;37(2 Pt 2):535-40.
2000: Kiyoshi Takeda; Toshihiro Ichiki; Tomotake Tokunou; Yuko Funakoshi; Naoko Iino; Katsuya Hirano; Hideo Kanaide; Akira Takeshita
Peroxisome proliferator-activated receptor gamma activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells.
Circulation 2000;102(15):1834-9.
2000: Toshihiro Ichiki; Yuko Funakoshi; Koji Ito; Akira Takeshita
Expression of monocyte chemoattractant protein-1 by nonenzymatically glycated albumin (Amadori adducts) in vascular smooth muscle cells.
Biochemical and biophysical research communications 2000;269(3):666-70.
2000: Kiyoshi Takeda; Toshihiro Ichiki; Yuko Funakoshi; Koji Ito; Akira Takeshita
Downregulation of angiotensin II type 1 receptor by all-trans retinoic acid in vascular smooth muscle cells.
Hypertension 2000;35(1 Pt 2):297-302.
1999: Yuko Funakoshi; Toshihiro Ichiki; Koji Ito; Akira Takeshita
Induction of interleukin-6 expression by angiotensin II in rat vascular smooth muscle cells.
Hypertension 1999;34(1):118-25.
1998: Makoto Katoh; Kensuke Egashira; Makoto Usui; Toshihiro Ichiki; H Tomita; Hiroaki Shimokawa; H Rakugi; Akira Takeshita
Cardiac angiotensin II receptors are upregulated by long-term inhibition of nitric oxide synthesis in rats.
Circulation research 1998;83(7):743-51.
1998: Makoto Usui; Toshihiro Ichiki; Makoto Katoh; Kensuke Egashira; Akira Takeshita
Regulation of angiotensin II receptor expression by nitric oxide in rat adrenal gland.
Hypertension 1998;32(3):527-33.
1998: Toshihiro Ichiki; Makoto Usui; M Kato; Yuko Funakoshi; Koji Ito; Kensuke Egashira; Akira Takeshita
Downregulation of angiotensin II type 1 receptor gene transcription by nitric oxide.
Hypertension 1998;31(1 Pt 2):342-8.