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Richard Austin

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Gazi S Hossain; John P Kane; Sárka Lhoták; Yonghong Li; Edward G Lynn; Kenneth N Maclean; Mary J Malloy; Christopher A McCulloch; Clive R Pullinger; Jaerang Rho; Dov Shiffman; Damu Tang; Bernardo Trigatti; Ji Zhou; Imtisal Al-Bondokji; John Capone; Jeffrey G Dickhout; Richard C Austin
Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin-1 Expression.
Sana Basseri; Rebecca J Ford; Morgan D Fullerton; Hua Jiang; Sárka Lhoták; Edward G Lynn; Kenneth N Maclean; Rengasamy Palanivel; Gregory R Steinberg; Richard C Austin
Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis.
Rachel E Carlisle; Celeste A Collins; Richard C Austin; Elise Brimble; Alana Heffernan; Danielle Jerome; Limin Liu; Peter J Margetts; Zahraa Mohammed-Ali; Jeffrey G Dickhout
TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium.

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All Publications

2013: Gazi S Hossain; John P Kane; Sárka Lhoták; Yonghong Li; Edward G Lynn; Kenneth N Maclean; Mary J Malloy; Christopher A McCulloch; Clive R Pullinger; Jaerang Rho; Dov Shiffman; Damu Tang; Bernardo Trigatti; Ji Zhou; Imtisal Al-Bondokji; John Capone; Jeffrey G Dickhout; Richard C Austin
Deficiency of TDAG51 Protects Against Atherosclerosis by Modulating Apoptosis, Cholesterol Efflux, and Peroxiredoxin-1 Expression.
Journal of the American Heart Association 2013;2(3):e000134.
2013: Sana Basseri; Rebecca J Ford; Morgan D Fullerton; Hua Jiang; Sárka Lhoták; Edward G Lynn; Kenneth N Maclean; Rengasamy Palanivel; Gregory R Steinberg; Richard C Austin
Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis.
Diabetes 2013;62(1):158-69.
2012: Rachel E Carlisle; Celeste A Collins; Richard C Austin; Elise Brimble; Alana Heffernan; Danielle Jerome; Limin Liu; Peter J Margetts; Zahraa Mohammed-Ali; Jeffrey G Dickhout
TDAG51 mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium.
American journal of physiology. Renal physiology 2012;303(3):F467-81.
2012: Sárka Lhoták; Adam Mazzetti; Sudesh Sood; Elise Brimble; Rachel E Carlisle; Stephen M Colgan; Jeffrey G Dickhout; Alistair J Ingram; Richard C Austin
ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death.
American journal of physiology. Renal physiology 2012;303(2):F266-78.
2012: Jeffrey G Dickhout; Sanjay Garg; Danielle E Jerome; Hua Jiang; Randal J Kaufman; Kenneth N Maclean; Sarathi Mani; Zahraa Mohammed-Ali; Rui Wang; Guangdong Yang; Ruma Banerjee; Rachel E Carlisle; Richard C Austin
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.
The Journal of biological chemistry 2012;287(10):7603-14.
2011: Jeffrey G Dickhout; Rachel E Carlisle; Richard C Austin
Interrelationship between cardiac hypertrophy, heart failure, and chronic kidney disease: endoplasmic reticulum stress as a mediator of pathogenesis.
Circulation research 2011;108(5):629-42.
2011: Jeffrey G Dickhout; Šárka Lhoták; Brooke A Hilditch; Sana Basseri; Stephen M Colgan; Edward G Lynn; Rachel E Carlisle; Ji Zhou; Sudesh K Sood; Alistair J Ingram; Richard C Austin
Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(2):576-89.
2011: Edward G Lynn; Richard C Austin
Hydrogen sulfide in the pathogenesis of atherosclerosis and its therapeutic potential.
Expert review of clinical pharmacology 2011;4(1):97-108.
2011: Lizhi He; Catherine Fan; Anil Kapoor; Alistair J Ingram; Adrian P Rybak; Richard C Austin; Jeffery Dickhout; Jean-Claude Cutz; James Scholey; Damu Tang
α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.
Nature communications 2011;2():307.
2011: Stephen M Colgan; Ali A Hashimi; Richard C Austin
Endoplasmic reticulum stress and lipid dysregulation.
Expert reviews in molecular medicine 2011;13():e4.
2011: Sárka Lhoták; Ji Zhou; Richard C Austin
Immunohistochemical detection of the unfolded protein response in atherosclerotic plaques.
Methods in enzymology 2011;489():23-46.
2010: Ali A Al-Hashimi; Jennifer Caldwell; Mario Gonzalez-Gronow; Salvatore V Pizzo; Danya Aboumrad; Lindsay Pozza; Hiam Al-Bayati; Jeffrey I Weitz; Alan Stafford; Howard Chan; Anil Kapoor; Donald W Jacobsen; Jeffrey G Dickhout; Richard C Austin
Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.
The Journal of biological chemistry 2010;285(37):28912-23.
2010: Jennifer A Caldwell; Jeffrey G Dickhout; Ali A Al-Hashimi; Richard C Austin
Development of a continuous assay for the measurement of tissue factor procoagulant activity on intact cells.
Laboratory investigation; a journal of technical methods and pathology 2010;90(6):953-62.
2009: Sana Basseri; Sárka Lhoták; Arya M Sharma; Richard C Austin
The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response.
Journal of lipid research 2009;50(12):2486-501.
2009: Kyoung-Jin Sohn; Hyeran Jang; Mihaela Campan; Daniel J Weisenberger; Jeffrey Dickhout; Yi-Cheng Wang; Robert C Cho; Zoe Yates; Mark Lucock; En-Pei Chiang; Richard C Austin; Sang-Woon Choi; Peter W Laird; Young-In Kim
The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: a possible molecular basis for the site-specific cancer risk modification.
International journal of cancer. Journal international du cancer 2009;124(9):1999-2005.
2009: Ji Zhou; Richard C Austin
Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms.
BioFactors (Oxford, England) 2009;35(2):120-9.
2008: Baldwin C Mak; Qin Wang; Carol A Laschinger; Wilson Lee; David Ron; Heather P Harding; Randal J Kaufman; Donalyn Scheuner; Richard C Austin; Christopher A McCulloch
Novel function of PERK as a mediator of force-induced apoptosis.
The Journal of biological chemistry 2008;283(34):23462-72.
2008: Ji Zhou; Geoff H Werstuck; Sárka Lhoták; Yuan Y Shi; Vivienne Tedesco; Bernardo L Trigatti; Jeffrey Dickhout; Alana K Majors; Patricia M DiBello; Donald W Jacobsen; Richard C Austin
Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(7):2569-78.
2007: Jeffrey G Dickhout; Sudesh K Sood; Richard C Austin
Role of endoplasmic reticulum calcium disequilibria in the mechanism of homocysteine-induced ER stress.
Antioxidants & redox signaling 2007;9(11):1863-73.
2007: Jeffrey G Dickhout; Stephen M Colgan; Sárka Lhoták; Richard C Austin
Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome: a balancing act between plaque stability and rupture.
Circulation 2007;116(11):1214-6.
2007: Stephen M Colgan; Damu Tang; Geoff Werstuck; Richard C Austin
Endoplasmic reticulum stress causes the activation of sterol regulatory element binding protein-2.
The international journal of biochemistry & cell biology 2007;39(10):1843-51.
2007: Stephen M Colgan; Richard C Austin
Homocysteinylation of metallothionein impairs intracellular redox homeostasis: the enemy within!
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):8-11.
2007: Katina M Wilson; Ryan B McCaw; Lorie Leo; Erland Arning; Sárka Lhoták; Teodoro Bottiglieri; Richard C Austin; Steven R Lentz
Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2007;27(1):233-40.
2006: Jeffrey G Dickhout; Richard C Austin
Proteasomal regulation of cardiac hypertrophy: is demolition necessary for building?
Circulation 2006;114(17):1796-8.
2005: Jeffrey G Dickhout; Gazi S Hossain; Lindsay M Pozza; Ji Zhou; Sárka Lhoták; Richard C Austin
Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(12):2623-9.
2005: Lindsay M Pozza; Richard C Austin
Getting a GRP on tissue factor activation.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1529-31.
2005: Ji Zhou; Sárka Lhoták; Brooke A Hilditch; Richard C Austin
Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice.
Circulation 2005;111(14):1814-21.
2005: Anna J Kim; Yuanyuan Shi; Richard C Austin; Geoff Werstuck
Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3.
Journal of cell science 2005;118(Pt 1):89-99.
2004: Alistair J Ingram; Joan C Krepinsky; Leighton James; Richard C Austin; Damu Tang; Anne Marie Salapatek; Kerri Thai; James W Scholey
Activation of mesangial cell MAPK in response to homocysteine.
Kidney international 2004;66(2):733-45.
2004: Ji Zhou; Geoff Werstuck; Sárka Lhoták; A B Lawrence de Koning; Sudesh K Sood; Gazi S Hossain; Jan Møller; Merel Ritskes-Hoitinga; Erling Falk; Sanjana Dayal; Steven R Lentz; Richard C Austin
Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice.
Circulation 2004;110(2):207-13.
2004: Richard C Austin; Steven R Lentz; Geoff Werstuck
Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease.
Cell death and differentiation 2004;11 Suppl 1():S56-64.
2003: A B Lawrence de Koning; Geoff Werstuck; Ji Zhou; Richard C Austin
Hyperhomocysteinemia and its role in the development of atherosclerosis.
Clinical biochemistry 2003;36(6):431-41.
2003: Gazi S Hossain; Johannes V van Thienen; Geoff Werstuck; Ji Zhou; Sudesh K Sood; Jeffrey G Dickhout; A B Lawrence de Koning; Damu Tang; Dongcheng Wu; Erling Falk; Ranjana Poddar; Donald W Jacobsen; Kezhong Zhang; Randal J Kaufman; Richard C Austin
TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia.
The Journal of biological chemistry 2003;278(32):30317-27.
2003: Ji Zhou; Jan Møller; Merel Ritskes-Hoitinga; Mogens Lytken Larsen; Richard C Austin; Erling Falk
Effects of vitamin supplementation and hyperhomocysteinemia on atherosclerosis in apoE-deficient mice.
Atherosclerosis 2003;168(2):255-62.
2003: Lindsay M Watson; Anthony K C Chan; Leslie R Berry; Jun Li; Sudesh K Sood; Jeffrey G Dickhout; Ling Xu; Geoff Werstuck; Laszlo Bajzar; Henry J Klamut; Richard C Austin
Overexpression of the 78-kDa glucose-regulated protein/immunoglobulin-binding protein (GRP78/BiP) inhibits tissue factor procoagulant activity.
The Journal of biological chemistry 2003;278(19):17438-47.
2002: Richard C Austin; Joan E B Fox; Geoff Werstuck; Alan R Stafford; Dennis E Bulman; Ghassan Y Dally; Cameron Ackerley; Jeffrey I Weitz; Peter N Ray
Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion.
The Journal of biological chemistry 2002;277(49):47106-13.
2002: Pasquale Cirone; Jacqueline M Bourgeois; Richard C Austin; Patricia L Chang
A novel approach to tumor suppression with microencapsulated recombinant cells.
Human gene therapy 2002;13(10):1157-66.
2001: Ji Zhou; Jan Møller; C C Danielsen; Jacob F Bentzon; Hanne Berg Ravn; Richard C Austin; Erling Falk
Dietary supplementation with methionine and homocysteine promotes early atherosclerosis but not plaque rupture in ApoE-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1470-6.
2001: Geoff Werstuck; Steven R Lentz; Sanjana Dayal; Gazi S Hossain; Sudesh K Sood; Y Y Shi; Ji Zhou; Nobuyo Maeda; S K Krisans; M Rene Malinow; Richard C Austin
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.
The Journal of clinical investigation 2001;107(10):1263-73.
2000: Pei-Xiang Li; J Wong; Ayeda Ayed; Duc Ngo; Anthony Brade; Cheryl H Arrowsmith; Richard C Austin; Henry J Klamut
Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression.
The Journal of biological chemistry 2000;275(26):20127-35.
2000: Richard C Austin; G E Morris; PL Howard; Henry J Klamut; Peter N Ray
Expression and synthesis of alternatively spliced variants of Dp71 in adult human brain.
Neuromuscular disorders : NMD 2000;10(3):187-93.
1999: Patricia C Y Liaw; Richard C Austin; James C Fredenburgh; Alan R Stafford; Jeffrey I Weitz
Comparison of heparin- and dermatan sulfate-mediated catalysis of thrombin inactivation by heparin cofactor II.
The Journal of biological chemistry 1999;274(39):27597-604.
1999: PA Outinen; Sudesh K Sood; S I Pfeifer; S Pamidi; Thomas J Podor; J Li; Jeffrey I Weitz; Richard C Austin
Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells.
Blood 1999;94(3):959-67.
1999: PL Howard; Ghassan Y Dally; S D Ditta; Richard C Austin; R G Worton; Henry J Klamut; Peter N Ray
Dystrophin isoforms DP71 and DP427 have distinct roles in myogenic cells.
Muscle & nerve 1999;22(1):16-27.
1998: Richard C Austin; Sudesh K Sood; A M Dorward; G Singh; Stephen G Shaughnessy; S Pamidi; PA Outinen; Jeffrey I Weitz
Homocysteine-dependent alterations in mitochondrial gene expression, function and structure. Homocysteine and H2O2 act synergistically to enhance mitochondrial damage.
The Journal of biological chemistry 1998;273(46):30808-17.
1998: PA Outinen; Sudesh K Sood; Patricia C Y Liaw; K D Sarge; N Maeda; Jack Hirsh; JC Ribau; Thomas J Podor; Jeffrey I Weitz; Richard C Austin
Characterization of the stress-inducing effects of homocysteine.
The Biochemical journal 1998;332 ( Pt 1)():213-21.
1998: Patricia C Y Liaw; James C Fredenburgh; Alan R Stafford; A Tulinsky; Richard C Austin; Jeffrey I Weitz
Localization of the thrombin-binding domain on prothrombin fragment 2.
The Journal of biological chemistry 1998;273(15):8932-9.
1996: S A Hill; Stephen G Shaughnessy; P Joshua; JC Ribau; Richard C Austin; Thomas J Podor
Differential mechanisms targeting type 1 plasminogen activator inhibitor and vitronectin into the storage granules of a human megakaryocytic cell line.
Blood 1996;87(12):5061-73.
1995: Richard C Austin; PL Howard; V N D'Souza; Henry J Klamut; Peter N Ray
Cloning and characterization of alternatively spliced isoforms of Dp71.
Human molecular genetics 1995;4(9):1475-83.
1995: Richard C Austin; D Singh; Patricia C Y Liaw; H J Craig
Visual detection method for identifying recombinant bacterial colonies.
BioTechniques 1995;18(3):380-2, 384.
1994: H Ni; John S Waye; Richard C Austin; D Calverley; Barry Eng; William P Sheffield; Morris A Blajchman
Characterization of a highly polymorphic trinucleotide short tandem repeat within the human antithrombin gene.
Thrombosis research 1994;74(3):303-7.
1992: Morris A Blajchman; Richard C Austin; F Fernandez-Rachubinski; William P Sheffield
Molecular basis of inherited human antithrombin deficiency.
Blood 1992;80(9):2159-71.
1992: Morris A Blajchman; F Fernandez-Rachubinski; William P Sheffield; Richard C Austin; S Schulman
Antithrombin-III-Stockholm: a codon 392 (Gly----Asp) mutation with normal heparin binding and impaired serine protease reactivity.
Blood 1992;79(6):1428-34.
1992: Richard C Austin; William P Sheffield; Richard A Rachubinski; Morris A Blajchman
The N-terminal domain of antithrombin-III is essential for heparin binding and complex-formation with, but not cleavage by, alpha-thrombin.
The Biochemical journal 1992;282 ( Pt 2)():345-51.
1991: Richard C Austin; Richard A Rachubinski; Frederick A Ofosu; Morris A Blajchman
Antithrombin-III-Hamilton, Ala 382 to Thr: an antithrombin-III variant that acts as a substrate but not an inhibitor of alpha-thrombin and factor Xa.
Blood 1991;77(10):2185-9.
1991: Richard C Austin; Richard A Rachubinski; Morris A Blajchman
Site-directed mutagenesis of alanine-382 of human antithrombin III.
FEBS letters 1991;280(2):254-8.
1990: Richard C Austin; Richard A Rachubinski; F Fernandez-Rachubinski; Morris A Blajchman
Expression in a cell-free system of normal and variant forms of human antithrombin III. Ability to bind heparin and react with alpha-thrombin.
Blood 1990;76(8):1521-9.
1990: A K Dudani; Richard C Austin; Thomas Venner; Radhey S Gupta
Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria.
Cytobios 1990;63(253):95-108.
1989: H E Manson; Richard C Austin; F Fernandez-Rachubinski; Richard A Rachubinski; Morris A Blajchman
The molecular pathology of inherited human antithrombin III deficiency.
Transfusion medicine reviews 1989;3(4):264-81.
1987: Radhey S Gupta; Richard C Austin
Mitochondrial matrix localization of a protein altered in mutants resistant to the microtubule inhibitor podophyllotoxin.
European journal of cell biology 1987;45(1):170-6.