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JR Idle

Research Profile

Chemicals & Drugs

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Los Angeles

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Gingival Hyperplasia

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Monica Holthe; T N Rakvåg; Pål Klepstad; JR Idle; Stein Kaasa; Hans E Krokan; Frank Skorpen
Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
Jean-Yves Chatton; JR Idle; C B Vågbø; Pierre J Magistretti
Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons.
L Grevle; C Güzey; Hakam Hadidi; R Brennersted; JR Idle; Jan Aasly
Allelic association between the DRD2 TaqI A polymorphism and Parkinson's disease.

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All Publications

2003: Monica Holthe; T N Rakvåg; Pål Klepstad; JR Idle; Stein Kaasa; Hans E Krokan; Frank Skorpen
Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients.
The pharmacogenomics journal 2003;3(1):17-26.
2001: Jean-Yves Chatton; JR Idle; C B Vågbø; Pierre J Magistretti
Insights into the mechanisms of ifosfamide encephalopathy: drug metabolites have agonistic effects on alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors and induce cellular acidification in mouse cortical neurons.
The Journal of pharmacology and experimental therapeutics 2001;299(3):1161-8.
2000: L Grevle; C Güzey; Hakam Hadidi; R Brennersted; JR Idle; Jan Aasly
Allelic association between the DRD2 TaqI A polymorphism and Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 2000;15(6):1070-4.
1999: Stephanie J London; JR Idle; Ann K Daly; G A Coetzee
Genetic variation of CYP2A6, smoking, and risk of cancer.
Lancet 1999;353(9156):898-9.
1998: Julian B S Leathart; Stephanie J London; A Steward; J D Adams; JR Idle; Ann K Daly
CYP2D6 phenotype-genotype relationships in African-Americans and Caucasians in Los Angeles.
Pharmacogenetics 1998;8(6):529-41.
1998: Hakam Hadidi; Y Irshaid; C B Vågbø; A Brunsvik; Suzanne Cholerton; K Zahlsen; JR Idle
Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6.
European journal of clinical pharmacology 1998;54(5):437-41.
1997: C Boustead; H Taber; JR Idle; Suzanne Cholerton
CYP2D6 genotype and smoking behaviour in cigarette smokers.
Pharmacogenetics 1997;7(5):411-4.
1997: Stephanie J London; T Sullivan-Klose; Ann K Daly; JR Idle
Lung cancer risk in relation to the CYP2C9 genetic polymorphism among Caucasians in Los Angeles County.
Pharmacogenetics 1997;7(5):401-4.
1997: Hakam Hadidi; K Zahlsen; JR Idle; Suzanne Cholerton
A single amino acid substitution (Leu160His) in cytochrome P450 CYP2A6 causes switching from 7-hydroxylation to 3-hydroxylation of coumarin.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(9):903-7.
1997: Stephanie J London; Ann K Daly; Julian B S Leathart; William Navidi; C C Carpenter; JR Idle
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.
Carcinogenesis 1997;18(6):1203-14.
1997: M Armstrong; Ann K Daly; R Blennerhassett; Nicol Ferrier; JR Idle
Antipsychotic drug-induced movement disorders in schizophrenics in relation to CYP2D6 genotype.
The British journal of psychiatry : the journal of mental science 1997;170():23-6.
1996: Stephanie J London; Ann K Daly; Julian B S Leathart; William Navidi; JR Idle
Lung cancer risk in relation to the CYP2C9*1/CYP2C9*2 genetic polymorphism among African-Americans and Caucasians in Los Angeles County, California.
Pharmacogenetics 1996;6(6):527-33.
1996: Roger Løvlie; Ann K Daly; Anders Molven; JR Idle; Vidar M Steen
Ultrarapid metabolizers of debrisoquine: characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene.
FEBS letters 1996;392(1):30-4.
1996: Ann K Daly; K S Fairbrother; O A Andreassen; Stephanie J London; JR Idle; Vidar M Steen
Characterization and PCR-based detection of two different hybrid CYP2D7P/CYP2D6 alleles associated with the poor metabolizer phenotype.
Pharmacogenetics 1996;6(4):319-28.
1996: Suzanne Cholerton; C Boustead; H Taber; A Arpanahi; JR Idle
CYP2D6 genotypes in cigarette smokers and non-tobacco users.
Pharmacogenetics 1996;6(3):261-3.
1996: Ann K Daly; J Brockmöller; F Broly; M Eichelbaum; William Evans; F J Gonzalez; J D Huang; JR Idle; M Ingelman-Sundberg; T Ishizaki; Evelyne Jacqz-Aigrain; U A Meyer; D W Nebert; Vidar M Steen; C Roland Wolf; Uli Zanger
Nomenclature for human CYP2D6 alleles.
Pharmacogenetics 1996;6(3):193-201.
1996: Alan V Boddy; M English; Andrew D J Pearson; JR Idle; R Skinner
Ifosfamide nephrotoxicity: limited influence of metabolism and mode of administration during repeated therapy in paediatrics.
European journal of cancer (Oxford, England : 1990) 1996;32A(7):1179-84.
1996: S C Monkman; Janice S Ellis; Suzanne Cholerton; J Mark Thomason; Robin A Seymour; JR Idle
Automated gas chromatographic assay for amlodipine in plasma and gingival crevicular fluid.
Journal of chromatography. B, Biomedical applications 1996;678(2):360-4.
1996: Stephanie J London; Ann K Daly; J Cooper; Catherine L Carpenter; William Navidi; L Ding; JR Idle
Lung cancer risk in relation to the CYP2E1 Rsa I genetic polymorphism among African-Americans and Caucasians in Los Angeles County.
Pharmacogenetics 1996;6(2):151-8.
1996: S Murray Yule; Alan V Boddy; M Cole; Lisa Price; RA Wyllie; M J Tasso; Andrew D J Pearson; JR Idle
Cyclophosphamide pharmacokinetics in children.
British journal of clinical pharmacology 1996;41(1):13-19.
1996: Ann K Daly; Vidar M Steen; K S Fairbrother; JR Idle
CYP2D6 multiallelism.
Methods in enzymology 1996;272():199-210.
1996: Alan V Boddy; S Murray Yule; RA Wyllie; Lisa Price; Andrew D J Pearson; JR Idle
Intrasubject variation in children of ifosfamide pharmacokinetics and metabolism during repeated administration.
Cancer chemotherapy and pharmacology 1996;38(2):147-54.
1995: Stephanie J London; Ann K Daly; K S Fairbrother; C Holmes; Catherine L Carpenter; William Navidi; JR Idle
Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism.
Cancer research 1995;55(24):6035-7.
1995: JR Idle; R L Smith
Pharmacogenetics in the new patterns of healthcare delivery.
Pharmacogenetics 1995;5(6):347-50.
1995: Hakam Hadidi; Y M Irshaid; R L Woosley; JR Idle; D A Flockhart
S-mephenytoin hydroxylation phenotypes in a Jordanian population.
Clinical pharmacology and therapeutics 1995;58(5):542-7.
1995: Stephanie J London; Ann K Daly; J Cooper; William Navidi; Catherine L Carpenter; JR Idle
Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.
Journal of the National Cancer Institute 1995;87(16):1246-53.
1995: Vidar M Steen; O A Andreassen; Ann K Daly; T Tefre; A L Børresen; JR Idle; AK Gulbrandsen
Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology.
Pharmacogenetics 1995;5(4):215-23.
1995: J Mark Thomason; Robin A Seymour; Janice S Ellis; PJ Kelly; G Parry; J Dark; JR Idle
Iatrogenic gingival overgrowth in cardiac transplantation.
Journal of periodontology 1995;66(8):742-6.
1995: Janice S Ellis; Robin A Seymour; J Mark Thomason; TJ Butler; JR Idle
Periodontal variables affecting nifedipine sequestration in gingival crevicular fluid.
Journal of periodontal research 1995;30(4):272-6.
1995: Ann K Daly; Julian B S Leathart; Stephanie J London; JR Idle
An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution.
Human genetics 1995;95(3):337-41.
1995: D de Berker; Sally H Ibbotson; N B Simpson; J N Matthews; JR Idle; Jonathan L Rees
Reduced experimental contact sensitivity in squamous cell but not basal cell carcinomas of skin.
Lancet 1995;345(8947):425-6.
1995: S Murray Yule; Alan V Boddy; M Cole; Lisa Price; RA Wyllie; M J Tasso; Andrew D J Pearson; JR Idle
Cyclophosphamide metabolism in children.
Cancer research 1995;55(4):803-9.
1995: Hakam Hadidi; Suzanne Cholerton; S Atkinson; Y M Irshaid; N M Rawashdeh; JR Idle
The N-oxidation of trimethylamine in a Jordanian population.
British journal of clinical pharmacology 1995;39(2):179-81.
1995: Alan V Boddy; M Cole; Andrew D J Pearson; JR Idle
The kinetics of the auto-induction of ifosfamide metabolism during continuous infusion.
Cancer chemotherapy and pharmacology 1995;36(1):53-60.
1995: Alan V Boddy; M Proctor; D Simmonds; Michael Lind; JR Idle
Pharmacokinetics, metabolism and clinical effect of ifosfamide in breast cancer patients.
European journal of cancer (Oxford, England : 1990) 1995;31A(1):69-76.
1995: Alan V Boddy; S Murray Yule; RA Wyllie; Lisa Price; Andrew D J Pearson; JR Idle
Comparison of continuous infusion and bolus administration of ifosfamide in children.
European journal of cancer (Oxford, England : 1990) 1995;31A(5):785-90.
1994: Ann K Daly; Suzanne Cholerton; M Armstrong; JR Idle
Genotyping for polymorphisms in xenobiotic metabolism as a predictor of disease susceptibility.
Environmental health perspectives 1994;102 Suppl 9():55-61.
1994: Hakam Hadidi; Suzanne Cholerton; S C Monkman; M Armstrong; Y M Irshaid; N M Rawashdeh; Ann K Daly; JR Idle
Debrisoquine 4-hydroxylation (CYP2D6) polymorphism in Jordanians.
Pharmacogenetics 1994;4(3):159-61.
1994: W L Gregory; Ann K Daly; A N Dunn; Gary Cavanagh; JR Idle; Oliver F W James; Margaret F Bassendine
Analysis of HLA-class-II-encoded antigen-processing genes TAP1 and TAP2 in primary biliary cirrhosis.
The Quarterly journal of medicine 1994;87(4):237-44.
1994: Robin A Seymour; Janice S Ellis; J Mark Thomason; S Monkman; JR Idle
Amlodipine-induced gingival overgrowth.
Journal of clinical periodontology 1994;21(4):281-3.
1994: M Armstrong; K Fairbrother; JR Idle; Ann K Daly
The cytochrome P450 CYP2D6 allelic variant CYP2D6J and related polymorphisms in a European population.
Pharmacogenetics 1994;4(2):73-81.
1994: T Tefre; Ann K Daly; M Armstrong; Julian B S Leathart; JR Idle; A Brøgger; A L Børresen
Genotyping of the CYP2D6 gene in Norwegian lung cancer patients and controls.
Pharmacogenetics 1994;4(2):47-57.
1994: W L Gregory; Frances Game; M Farrer; JR Idle; MF Laker; Oliver F W James
Reduced serum lipoprotein(a) levels in patients with primary biliary cirrhosis.
Atherosclerosis 1994;105(1):43-50.
1994: Suzanne Cholerton; A Arpanahi; N McCracken; C Boustead; H Taber; E Johnstone; Julian B S Leathart; Ann K Daly; JR Idle
Poor metabolisers of nicotine and CYP2D6 polymorphism.
Lancet 1994;343(8888):62-3.
1993: Janice S Ellis; S C Monkman; Robin A Seymour; JR Idle
Determination of nifedipine in gingival crevicular fluid: a capillary gas chromatographic method for nifedipine in microlitre volumes of biological fluid.
Journal of chromatography 1993;621(1):95-101.
1993: W L Gregory; Oliver F W James; I Turner; C O Meese; JR Idle
Re-evaluation of the metabolism of carbocisteine in a British white population.
Pharmacogenetics 1993;3(5):270-4.
1993: JR Idle; Ann K Daly
New opportunities in cancer risk evaluation using PCR-based DNA analysis for CYP2D6.
Environmental health perspectives 1993;101 Suppl 3():117-20.
1993: Janice S Ellis; Robin A Seymour; S Monkman; JR Idle
Disposition of nifedipine in plasma and gingival crevicular fluid in relation to drug-induced gingival overgrowth.
Journal of periodontal research 1993;28(5):373-8.
1993: Alan V Boddy; S Murray Yule; RA Wyllie; Lisa Price; Andrew D J Pearson; JR Idle
Pharmacokinetics and metabolism of ifosfamide administered as a continuous infusion in children.
Cancer research 1993;53(16):3758-64.
1993: M Armstrong; JR Idle; Ann K Daly
A polymorphic CfoI site in exon 6 of the human cytochrome P450 CYP2D6 gene detected by the polymerase chain reaction.
Human genetics 1993;91(6):616-7.
1993: W L Gregory; W Mehal; A N Dunn; Gary Cavanagh; R Chapman; K A Fleming; Ann K Daly; JR Idle; Oliver F W James; Margaret F Bassendine
Primary biliary cirrhosis: contribution of HLA class II allele DR8.
The Quarterly journal of medicine 1993;86(6):393-9.
1993: Janice S Ellis; Robin A Seymour; J Mark Thomason; S C Monkman; JR Idle
Gingival sequestration of amlodipine and amlodipine-induced gingival overgrowth.
Lancet 1993;341(8852):1102-3.
1993: Ann K Daly; Suzanne Cholerton; W Gregory; JR Idle
Metabolic polymorphisms.
Pharmacology & therapeutics 1993;57(2-3):129-60.
1992: JR Idle; M Armstrong; Alan V Boddy; C Boustead; Suzanne Cholerton; J Cooper; Ann K Daly; J Ellis; W Gregory; Hakam Hadidi
The pharmacogenetics of chemical carcinogenesis.
Pharmacogenetics 1992;2(6):246-58.
1992: Suzanne Cholerton; Ann K Daly; JR Idle
The role of individual human cytochromes P450 in drug metabolism and clinical response.
Trends in pharmacological sciences 1992;13(12):434-9.
1992: A V Boddy; Y Furtun; Semra Sardas; O Sardas; JR Idle
Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide.
Journal of the National Cancer Institute 1992;84(22):1744-8.
1992: Janice S Ellis; Robin A Seymour; S C Monkman; JR Idle
Gingival sequestration of nifedipine in nifedipine-induced gingival overgrowth.
Lancet 1992;339(8806):1382-3.
1992: S Barclay; J Mark Thomason; JR Idle; Robin A Seymour
The incidence and severity of nifedipine-induced gingival overgrowth.
Journal of clinical periodontology 1992;19(5):311-4.
1992: M Armstrong; Ann K Daly; Suzanne Cholerton; D N Bateman; JR Idle
Mutant debrisoquine hydroxylation genes in Parkinson's disease.
Lancet 1992;339(8800):1017-8.
1992: Suzanne Cholerton; M E Idle; A Vas; F J Gonzalez; JR Idle
Comparison of a novel thin-layer chromatographic-fluorescence detection method with a spectrofluorometric method for the determination of 7-hydroxycoumarin in human urine.
Journal of chromatography 1992;575(2):325-30.
1992: Alan V Boddy; JR Idle
Combined thin-layer chromatography-photography-densitometry for the quantification of ifosfamide and its principal metabolites in urine, cerebrospinal fluid and plasma.
Journal of chromatography 1992;575(1):137-42.
1992: Ann K Daly; B S Salh; Diana Bilton; J Allen; Alastair Knight; A K Webb; J M Braganza; JR Idle
Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds.
Pharmacogenetics 1992;2(1):19-24.
1992: M J Tasso; Alan V Boddy; Lisa Price; RA Wyllie; Andrew D J Pearson; JR Idle
Pharmacokinetics and metabolism of cyclophosphamide in paediatric patients.
Cancer chemotherapy and pharmacology 1992;30(3):207-11.
1991: Ann K Daly; M Armstrong; S C Monkman; M E Idle; JR Idle
Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes.
Pharmacogenetics 1991;1(1):33-41.
1991: JR Idle
Is environmental carcinogenesis modulated by host polymorphism?
Mutation research 1991;247(2):259-66.
1990: C Edwards; S Monkman; Suzanne Cholerton; M D Rawlins; JR Idle; R E Ferner
Lack of effect of co-trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine.
British journal of clinical pharmacology 1990;30(6):889-91.
1990: R E Ferner; S Monkman; J Riley; Suzanne Cholerton; JR Idle; D N Bateman
Pharmacokinetics and toxic effects of nifedipine in massive overdose.
Human & experimental toxicology 1990;9(5):309-11.