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Giandomenica Iezzi

Research Profile

Living Beings

Anatomy

Chemicals & Drugs

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Colorectal Neoplasms

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Maria Philippova; Andreas W Schoenenberger; Giulio C Spagnoli; Stanislaw Buechner; Paul Erne; Giandomenica Iezzi; Emmanouil Kyriakakis; Dennis Pfaff; Therese J Resink
T-cadherin loss promotes experimental metastasis of squamous cell carcinoma.
Manuele Giuseppe Muraro; Valentina Mele; Giulio Cesare Spagnoli; Silvio Däster; Junyi Han; Michael Heberer; Giandomenica Iezzi
CD133+, CD166+CD44+, and CD24+CD44+ phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal cancer cell lines.
Dennis Pfaff; Maria Philippova; Katharina Rupp; Giulio C Spagnoli; Stanislaw Buechner; Paul Erne; Giandomenica Iezzi; Emmanouil Kyriakakis; Kseniya Maslova; Therese J Resink
Paradoxical effects of T-cadherin on squamous cell carcinoma: up- and down-regulation increase xenograft growth by distinct mechanisms.

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All Publications

2013: Maria Philippova; Andreas W Schoenenberger; Giulio C Spagnoli; Stanislaw Buechner; Paul Erne; Giandomenica Iezzi; Emmanouil Kyriakakis; Dennis Pfaff; Therese J Resink
T-cadherin loss promotes experimental metastasis of squamous cell carcinoma.
European journal of cancer (Oxford, England : 1990) 2013;49(8):2048-58.
2012: Manuele Giuseppe Muraro; Valentina Mele; Giulio Cesare Spagnoli; Silvio Däster; Junyi Han; Michael Heberer; Giandomenica Iezzi
CD133+, CD166+CD44+, and CD24+CD44+ phenotypes fail to reliably identify cell populations with cancer stem cell functional features in established human colorectal cancer cell lines.
Stem cells translational medicine 2012;1(8):592-603.
2011: Dennis Pfaff; Maria Philippova; Katharina Rupp; Giulio C Spagnoli; Stanislaw Buechner; Paul Erne; Giandomenica Iezzi; Emmanouil Kyriakakis; Kseniya Maslova; Therese J Resink
Paradoxical effects of T-cadherin on squamous cell carcinoma: up- and down-regulation increase xenograft growth by distinct mechanisms.
The Journal of pathology 2011;225(4):512-24.
2011: Elke Schultz-Thater; Luigi Terracciano; Luigi Tornillo; Paul Zajac; Vincenza Carafa; Giandomenica Iezzi; Clémentine Le Magnen; Salvatore Piscuoglio; Giulio C Spagnoli
MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies.
International journal of cancer. Journal international du cancer 2011;129(5):1137-48.
2011: Giuseppe Sconocchia; Inti Zlobec; Alessandro Lugli; Diego Calabrese; Giandomenica Iezzi; Eva Karamitopoulou; Efstratios S Patsouris; George Peros; Milo Horcic; Luigi Tornillo; Markus Zuber; Raoul Droeser; Manuele G Muraro; Chantal Mengus; Daniel Oertli; Soldano Ferrone; Luigi Terracciano; Giulio C Spagnoli
Tumor infiltration by FcγRIII (CD16)+ myeloid cells is associated with improved survival in patients with colorectal carcinoma.
International journal of cancer. Journal international du cancer 2011;128(11):2663-72.
2010: Chiara Bocelli Tyndall; Paul Zajac; Nunzia Di Maggio; Emanuele Trella; Federica Benvenuto; Giandomenica Iezzi; Arnaud Scherberich; Andrea Barbero; Stefan Schaeren; Vito Pistoia; Giulio Spagnoli; Mirko Vukcevic; Ivan Martin; Alan Tyndall
Fibroblast growth factor 2 and platelet-derived growth factor, but not platelet lysate, induce proliferation-dependent, functional class II major histocompatibility complex antigen in human mesenchymal stem cells.
Arthritis and rheumatism 2010;62(12):3815-25.
2010: Anna Fialová; Zdenek Cimburek; Giandomenica Iezzi; Jan Kopecký
Ixodes ricinus tick saliva modulates tick-borne encephalitis virus infection of dendritic cells.
Microbes and infection / Institut Pasteur 2010;12(7):580-5.
2010: Giulio C Spagnoli; Marzieh Ebrahimi; Giandomenica Iezzi; Chantal Mengus; Paul Zajac
Contemporary immunotherapy of solid tumors: from tumor-associated antigens to combination treatments.
Current opinion in drug discovery & development 2010;13(2):184-92.
2010: Inti Zlobec; Eva Karamitopoulou; Luigi Terracciano; Salvatore Piscuoglio; Giandomenica Iezzi; Manuele Giuseppe Muraro; Giulio Spagnoli; Kristi Baker; Alexandar Tzankov; Alessandro Lugli
TIA-1 cytotoxic granule-associated RNA binding protein improves the prognostic performance of CD8 in mismatch repair-proficient colorectal cancer.
PloS one 2010;5(12):e14282.
2009: Inti Zlobec; Ursula Günthert; Luigi Tornillo; Giandomenica Iezzi; Daniel Baumhoer; Luigi Terracciano; Alessandro Lugli
Systematic assessment of the prognostic impact of membranous CD44v6 protein expression in colorectal cancer.
Histopathology 2009;55(5):564-75.
2009: Johannes Haybaeck; Nicolas Zeller; Monika Julia Wolf; Achim Weber; Ulrich Wagner; Michael Odo Kurrer; Juliane Bremer; Giandomenica Iezzi; Rolf Graf; Pierre-Alain Clavien; Robert Thimme; Hubert Blum; Sergei A Nedospasov; Kurt Zatloukal; Muhammad Ramzan; Sandra Ciesek; Thomas Pietschmann; Patrice N Marche; Michael Karin; Manfred Kopf; Jeffrey L Browning; Adriano Aguzzi; Mathias Heikenwalder
A lymphotoxin-driven pathway to hepatocellular carcinoma.
Cancer cell 2009;16(4):295-308.
2009: Rachel Rosenthal; Célia Groeper; Laura Bracci; Michel Adamina; Chantal Feder-Mengus; Paul Zajac; Giandomenica Iezzi; Martin Bolli; Walter P Weber; Daniel M Frey; Urs von Holzen; Daniel Oertli; Michael Heberer; Giulio C Spagnoli
Differential responsiveness to IL-2, IL-7, and IL-15 common receptor gamma chain cytokines by antigen-specific peripheral blood naive or memory cytotoxic CD8+ T cells from healthy donors and melanoma patients.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2009;32(3):252-61.
2009: Giandomenica Iezzi; Ivo Sonderegger; Franziska Ampenberger; Nicole Schmitz; Benjamin J Marsland; Manfred Kopf
CD40-CD40L cross-talk integrates strong antigenic signals and microbial stimuli to induce development of IL-17-producing CD4+ T cells.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(3):876-81.
2008: Mirko Vukcevic; Giulio C Spagnoli; Giandomenica Iezzi; Francesco Zorzato; Susan Treves
Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression.
The Journal of biological chemistry 2008;283(50):34913-22.
2008: Ivo Sonderegger; Giandomenica Iezzi; Reinhard Maier; Nicole Schmitz; Michael O Kurrer; Manfred Kopf
GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival.
The Journal of experimental medicine 2008;205(10):2281-94.
2008: Laura Bracci; Reto Schumacher; Maurizio Provenzano; Michel Adamina; Rachel Rosenthal; Celia Groeper; Paul Zajac; Giandomenica Iezzi; Enrico Proietti; Filippo Belardelli; Giulio C Spagnoli
Efficient stimulation of T cell responses by human IFN-alpha-induced dendritic cells does not require Toll-like receptor triggering.
Journal of immunotherapy (Hagerstown, Md. : 1997) 2008;31(5):466-74.
2008: Anna Skallová; Giandomenica Iezzi; Franziska Ampenberger; Manfred Kopf; Jan Kopecky
Tick saliva inhibits dendritic cell migration, maturation, and function while promoting development of Th2 responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(9):6186-92.
2006: Andrea Boni; Giandomenica Iezzi; Elena Degl'Innocenti; Matteo Grioni; Elena Jachetti; Annalisa Camporeale; Matteo Bellone
Prolonged exposure of dendritic cells to maturation stimuli favors the induction of type-2 cytotoxic T lymphocytes.
European journal of immunology 2006;36(12):3157-66.
2006: Ivo Sonderegger; Till A Röhn; Michael O Kurrer; Giandomenica Iezzi; Yu Zou; Robert A Kastelein; Martin F Bachmann; Manfred Kopf
Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis.
European journal of immunology 2006;36(11):2849-56.
2006: Giandomenica Iezzi; Andrea Boni; Elena Degl'Innocenti; Matteo Grioni; Maria T S Bertilaccio; Matteo Bellone
Type 2 cytotoxic T lymphocytes modulate the activity of dendritic cells toward type 2 immune responses.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(4):2131-7.
2006: Giandomenica Iezzi; Anja Fröhlich; Bettina Ernst; Franziska Ampenberger; Sem Saeland; Nicolas Glaichenhaus; Manfred Kopf
Lymph node resident rather than skin-derived dendritic cells initiate specific T cell responses after Leishmania major infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(2):1250-6.
2003: Annalisa Camporeale; Andrea Boni; Giandomenica Iezzi; Elena Degl'Innocenti; Matteo Grioni; Anna Mondino; Matteo Bellone
Critical impact of the kinetics of dendritic cells activation on the in vivo induction of tumor-specific T lymphocytes.
Cancer research 2003;63(13):3688-94.
2003: Urs Eriksson; Michael O Kurrer; Ivo Sonderegger; Giandomenica Iezzi; Anna Tafuri; Lukas Hunziker; Shinobu Suzuki; Kurt Bachmaier; Roland Bingisser; Josef M Penninger; Manfred Kopf
Activation of dendritic cells through the interleukin 1 receptor 1 is critical for the induction of autoimmune myocarditis.
The Journal of experimental medicine 2003;197(3):323-31.
1999: Matteo Bellone; Giandomenica Iezzi; MA Imro; Maria Pia Protti
Cancer immunotherapy: synthetic and natural peptides in the balance.
Immunology today 1999;20(10):457-62.
1999: A Ronchetti; Giandomenica Iezzi; Mariacristina Crosti; MP Garancini; Maria Pia Protti; Matteo Bellone
Role of antigen-presenting cells in cross-priming of cytotoxic T lymphocytes by apoptotic cells.
Journal of leukocyte biology 1999;66(2):247-51.
1999: A Ronchetti; Patrizia Rovere-Querini; Giandomenica Iezzi; Giovanni Galati; S Heltai; Maria Pia Protti; MP Garancini; angelo manfredi; Claudio Rugarli; Matteo Bellone
Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(1):130-6.
1997: Matteo Bellone; Giandomenica Iezzi; Patrizia Rovere-Querini; Giovanni Galati; A Ronchetti; Maria Pia Protti; Jean Davoust; Claudio Rugarli; angelo manfredi
Processing of engulfed apoptotic bodies yields T cell epitopes.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(11):5391-9.
1997: Giandomenica Iezzi; L Rivolta; A Ronchetti; Alfonso Martin-Fontecha; A Rosato; Maria Pia Protti; Maria Grazia Sabbadini; Matteo Bellone
The immunogenicity of experimental tumors is strongly biased by the expression of dominant viral cytotoxic T-lymphocyte epitopes.
Cancer research 1997;57(13):2564-8.
1997: Matteo Bellone; Giandomenica Iezzi; Alfonso Martin-Fontecha; L Rivolta; angelo manfredi; Maria Pia Protti; Massimo Freschi; Paolo Dellabona; Giulia Casorati; Claudio Rugarli
Rejection of a nonimmunogenic melanoma by vaccination with natural melanoma peptides on engineered antigen-presenting cells.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(2):783-9.
1996: A Martin-Fontecha; Federica Cavallo; Matteo Bellone; S Heltai; Giandomenica Iezzi; P Tornaghi; N Nabavi; Guido Forni; Paolo Dellabona; Giulia Casorati
Heterogeneous effects of B7-1 and B7-2 in the induction of both protective and therapeutic anti-tumor immunity against different mouse tumors.
European journal of immunology 1996;26(8):1851-9.
1996: Giandomenica Iezzi; Maria Pia Protti; Claudio Rugarli; Matteo Bellone
B7.1 expression on tumor cells circumvents the need of professional antigen presentation for in vitro propagation of cytotoxic T cell lines.
Cancer research 1996;56(1):11-5.
1994: Matteo Bellone; Giandomenica Iezzi; angelo manfredi; Maria Pia Protti; Paolo Dellabona; Giulia Casorati; Claudio Rugarli
In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells.
European journal of immunology 1994;24(11):2691-8.