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Manuela Iezzi

Research Profile

Living Beings

Chemicals & Drugs

Disorders

Genes & Molecular Sequences

Genes, erbB-2

Anatomy

Tumor Cell Line

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Publications

TOP 3
Laura Conti; Guido Forni; Manuela Iezzi; Stefania Lanzardo; Alessandro Maiocchi; Monica Montone; Elisabetta Bolli; Chiara Brioschi; Federica Cavallo
Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding αv β3 integrins.
Patrizia Nanni; Giordano Nicoletti; Arianna Palladini; Laura Menotti; Gabriella Campadelli-Fiume; Stefania Croci; Massimiliano Dall'ora; Carla De Giovanni; Valentina Gatta; Valentina Grosso; Marianna Ianzano; Manuela Iezzi; Lorena Landuzzi; Pier-Luigi Lollini
Preclinical therapy of disseminated HER-2⁺ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.
Carla De Giovanni; V Grosso; M L Ianzano; Manuela Iezzi; Lorena Landuzzi; R M Lemoli; A Murgo; Patrizia Nanni; G Nicoletti; Arianna Palladini; F Romani; V Stivani; L Stramucci; A Antognoli; E Barbieri; Stefania Croci; Pier-Luigi Lollini
Human responses against HER-2-positive cancer cells in human immune system-engrafted mice.

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All Publications

2013: Laura Conti; Guido Forni; Manuela Iezzi; Stefania Lanzardo; Alessandro Maiocchi; Monica Montone; Elisabetta Bolli; Chiara Brioschi; Federica Cavallo
Optical imaging detection of microscopic mammary cancer in ErbB-2 transgenic mice through the DA364 probe binding αv β3 integrins.
Contrast media & molecular imaging 2013;8(4):350-60.
2013: Patrizia Nanni; Giordano Nicoletti; Arianna Palladini; Laura Menotti; Gabriella Campadelli-Fiume; Stefania Croci; Massimiliano Dall'ora; Carla De Giovanni; Valentina Gatta; Valentina Grosso; Marianna Ianzano; Manuela Iezzi; Lorena Landuzzi; Pier-Luigi Lollini
Preclinical therapy of disseminated HER-2⁺ ovarian and breast carcinomas with a HER-2-retargeted oncolytic herpesvirus.
PLoS pathogens 2013;9(1):e1003155.
2012: Carla De Giovanni; V Grosso; M L Ianzano; Manuela Iezzi; Lorena Landuzzi; R M Lemoli; A Murgo; Patrizia Nanni; G Nicoletti; Arianna Palladini; F Romani; V Stivani; L Stramucci; A Antognoli; E Barbieri; Stefania Croci; Pier-Luigi Lollini
Human responses against HER-2-positive cancer cells in human immune system-engrafted mice.
British journal of cancer 2012;107(8):1302-9.
2012: Maddalena Arigoni; Irmeli Barkefors; Giuseppina Barutello; Claudia Curcio; Lars Holmgren; Manuela Iezzi; Stefania Lanzardo; Dario Longo; Yujuan Zheng; Silvio Aime; Federica Cavallo
A vaccine targeting angiomotin induces an antibody response which alters tumor vessel permeability and hampers the growth of established tumors.
Angiogenesis 2012;15(2):305-16.
2012: Patrizia Nanni; Giordano Nicoletti; Arianna Palladini; Valeria Stivani; Annalisa Murgo; Agnese Antognoli; Stefania Croci; Carla De Giovanni; Emmanuelle di Tomaso; Valentina Grosso; Marianna L Ianzano; Manuela Iezzi; Alessia Lamolinara; Lorena Landuzzi; Pier-Luigi Lollini
Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor.
PloS one 2012;7(6):e39626.
2011: Manuela Iezzi; Piero Musiani; Elena Quaglino; F Sabatini; V Toto; Paola Cappello; C Curcio; G Garotta; Federica Cavallo
HCG hastens both the development of mammary carcinoma and the metastatization of HCG/LH and ERBB-2 receptor-positive cells in mice.
International journal of immunopathology and pharmacology 2011;24(3):621-30.
2010: Marta Coscia; Elena Quaglino; Manuela Iezzi; Claudia Curcio; Francesca Pantaleoni; Chiara Riganti; Ingunn Holen; Hannu Mönkkönen; Mario Boccadoro; Guido Forni; Piero Musiani; Amalia Bosia; Federica Cavallo; Massimo Massaia
Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway.
Journal of cellular and molecular medicine 2010;14(12):2803-15.
2010: Sara Cabodi; Agata Tinnirello; Brigitte Bisaro; Giusy Tornillo; Maria del Pilar Camacho-Leal; Guido Forni; Rodica Cojoca; Manuela Iezzi; Augusto Amici; Maura Montani; Alessandra Eva; Paola Di Stefano; Senthil K Muthuswamy; Guido Tarone; Emilia Turco; Paola Defilippi
p130Cas is an essential transducer element in ErbB2 transformation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(10):3796-808.
2010: Simona Rolla; Francesco Ria; Sergio Occhipinti; Gabriele Di Sante; Manuela Iezzi; Michela Spadaro; Chiara Nicolò; Elena Ambrosino; Irene Fiore Merighi; Piero Musiani; Guido Forni; Federica Cavallo
Erbb2 DNA vaccine combined with regulatory T cell deletion enhances antibody response and reveals latent low-avidity T cells: potential and limits of its therapeutic efficacy.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(11):6124-32.
2010: Elisa Ciraolo; Fulvio Morello; Robin M Hobbs; Frieder Wolf; Romina Marone; Manuela Iezzi; Xiaoyun Lu; Giulio Mengozzi; Fiorella Altruda; Giovanni Sorba; Kaomei Guan; Pier Paolo Pandolfi; Matthias P Wymann; Emilio Hirsch
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.
Molecular biology of the cell 2010;21(5):704-11.
2009: Carla De Giovanni; Giordano Nicoletti; Arianna Palladini; Stefania Croci; Lorena Landuzzi; A Antognoli; A Murgo; Annalisa Astolfi; Silvano Ferrini; M Fabbi; Anna Maria Orengo; Augusto Amici; M L Penichet; L Aurisicchio; Manuela Iezzi; Piero Musiani; Patrizia Nanni; Pier-Luigi Lollini
A multi-DNA preventive vaccine for p53/Neu-driven cancer syndrome.
Human gene therapy 2009;20(5):453-64.
2009: Carla De Giovanni; Giordano Nicoletti; Lorena Landuzzi; Stefania Croci; Arianna Palladini; Agnese Antognoli; Annalisa Murgo; Marianna L Ianzano; Valentina Grosso; Valeria Stivani; Manuela Iezzi; Piero Musiani; Patrizia Nanni; Pier-Luigi Lollini
Tamoxifen combined to anti-HER-2/neu cell vaccine does not hamper cancer immunopreventive efficacy.
Vaccine 2009;27(14):2065-9.
2007: Patrizia Nanni; Giordano Nicoletti; Arianna Palladini; Stefania Croci; Annalisa Murgo; Agnese Antognoli; Lorena Landuzzi; Marina Fabbi; Silvano Ferrini; Piero Musiani; Manuela Iezzi; Carla De Giovanni; Pier-Luigi Lollini
Antimetastatic activity of a preventive cancer vaccine.
Cancer research 2007;67(22):11037-44.
2007: Carla De Giovanni; Stefania Croci; Giordano Nicoletti; Lorena Landuzzi; Arianna Palladini; Tania Pannellini; Ludovica Borgia; Manuela Iezzi; Emma Di Carlo; Anna Maria Orengo; Ronald C Kennedy; Pier-Luigi Lollini; Patrizia Nanni; Piero Musiani
Inhibition of prostate carcinogenesis by combined active immunoprophylaxis.
International journal of cancer. Journal international du cancer 2007;121(1):88-94.
2006: Elena Ambrosino; Michela Spadaro; Manuela Iezzi; Claudia Curcio; Guido Forni; Piero Musiani; Wei-Zen Wei; Federica Cavallo
Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.
Cancer research 2006;66(15):7734-40.
2006: Tania Pannellini; Michela Spadaro; Emma Di Carlo; Elena Ambrosino; Manuela Iezzi; Augusto Amici; Pier-Luigi Lollini; Guido Forni; Federica Cavallo; Piero Musiani
Timely DNA vaccine combined with systemic IL-12 prevents parotid carcinomas before a dominant-negative p53 makes their growth independent of HER-2/neu expression.
Journal of immunology (Baltimore, Md. : 1950) 2006;176(12):7695-703.
2006: Lars Holmgren; Elena Ambrosino; Olivier Birot; Carl Tullus; Niina Veitonmäki; Tetyana Levchenko; Lena-Maria Carlson; Piero Musiani; Manuela Iezzi; Claudia Curcio; Guido Forni; Federica Cavallo; Rolf Kiessling
A DNA vaccine targeting angiomotin inhibits angiogenesis and suppresses tumor growth.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9208-13.
2006: Mauro Piantelli; Cosmo Rossi; Manuela Iezzi; Rossana La Sorda; Stefano Iacobelli; Saverio Alberti; Pier Giorgio Natali
Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions.
Journal of cellular physiology 2006;207(1):23-9.
2005: Federica Cavallo; Annalisa Astolfi; Manuela Iezzi; Francesca Cordero; Pier-Luigi Lollini; Guido Forni; Raffaele A Calogero
An integrated approach of immunogenomics and bioinformatics to identify new Tumor Associated Antigens (TAA) for mammary cancer immunological prevention.
BMC bioinformatics 2005;6 Suppl 4():S7.
2005: Gianluca Maddalo; Francesca Petrucci; Manuela Iezzi; Tania Pannellini; Piero Del Boccio; Domenico Ciavardelli; Antonino Biroccio; Federica Forlì; Carmine Di Ilio; Enzo Ballone; Andrea Urbani; Giorgio Federici
Analytical assessment of MALDI-TOF Imaging Mass Spectrometry on thin histological samples. An insight in proteome investigation.
Clinica chimica acta; international journal of clinical chemistry 2005;357(2):210-8.
2005: Annalisa Astolfi; Simona Rolla; Patrizia Nanni; Elena Quaglino; Carla De Giovanni; Manuela Iezzi; Piero Musiani; Guido Forni; Pier-Luigi Lollini; Federica Cavallo; Raffaele A Calogero
Immune prevention of mammary carcinogenesis in HER-2/neu transgenic mice: a microarray scenario.
Cancer immunology, immunotherapy : CII 2005;54(6):599-610.
2005: Elena Quaglino; Cristina Mastini; Manuela Iezzi; Guido Forni; Piero Musiani; Leah N Klapper; Britta Hardy; Federica Cavallo
The adjuvant activity of BAT antibody enables DNA vaccination to inhibit the progression of established autochthonous Her-2/neu carcinomas in BALB/c mice.
Vaccine 2005;23(25):3280-7.
2005: Marco Lo Iacono; Federica Cavallo; Elena Quaglino; Simona Rolla; Manuela Iezzi; Serenella M Pupa; Carla De Giovanni; Pier-Luigi Lollini; Piero Musiani; Guido Forni; Raffaele A Calogero
A limited autoimmunity to p185neu elicited by DNA and allogeneic cell vaccine hampers the progression of preneoplastic lesions in HER-2/NEU transgenic mice.
International journal of immunopathology and pharmacology 2005;18(2):351-63.
2005: Annalisa Astolfi; Lorena Landuzzi; Giordano Nicoletti; Carla De Giovanni; Stefania Croci; Arianna Palladini; Silvano Ferrini; Manuela Iezzi; Piero Musiani; Federica Cavallo; Guido Forni; Patrizia Nanni; Pier-Luigi Lollini
Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary carcinoma.
The American journal of pathology 2005;166(4):1205-16.
2005: Michela Spadaro; Elena Ambrosino; Manuela Iezzi; Emma Di Carlo; Pamela Sacchetti; Claudia Curcio; Augusto Amici; Wei-Zen Wei; Piero Musiani; Pier-Luigi Lollini; Federica Cavallo; Guido Forni
Cure of mammary carcinomas in Her-2 transgenic mice through sequential stimulation of innate (neoadjuvant interleukin-12) and adaptive (DNA vaccine electroporation) immunity.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(5):1941-52.
2005: Serenella M Pupa; Manuela Iezzi; Emma Di Carlo; Annamaria Invernizzi; Federica Cavallo; Raffaella Meazza; Alberto Comes; Silvano Ferrini; Piero Musiani; Sylvie Ménard
Inhibition of mammary carcinoma development in HER-2/neu transgenic mice through induction of autoimmunity by xenogeneic DNA vaccination.
Cancer research 2005;65(3):1071-8.
2004: Patrizia Nanni; Lorena Landuzzi; Giordano Nicoletti; Carla De Giovanni; Ilaria Rossi; Stefania Croci; Annalisa Astolfi; Manuela Iezzi; Emma Di Carlo; Piero Musiani; Guido Forni; Pier-Luigi Lollini
Immunoprevention of mammary carcinoma in HER-2/neu transgenic mice is IFN-gamma and B cell dependent.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(4):2288-96.
2004: Carla De Giovanni; Giordano Nicoletti; Lorena Landuzzi; Annalisa Astolfi; Stefania Croci; Alberto Comes; Silvano Ferrini; Raffaella Meazza; Manuela Iezzi; Emma Di Carlo; Piero Musiani; Federica Cavallo; Patrizia Nanni; Pier-Luigi Lollini
Immunoprevention of HER-2/neu transgenic mammary carcinoma through an interleukin 12-engineered allogeneic cell vaccine.
Cancer research 2004;64(11):4001-9.
2004: Tania Pannellini; Manuela Iezzi; Emma Di Carlo; E Eleuterio; Anna Coletti; Andrea Modesti; S Rosini; MATTEO NERI; Piero Musiani
The expression of LEC/CCL16, a powerful inflammatory chemokine, is upregulated in ulcerative colitis.
International journal of immunopathology and pharmacology 2004;17(2):171-80.
2004: Elena Quaglino; Manuela Iezzi; Cristina Mastini; Augusto Amici; Federica Pericle; Emma Di Carlo; Serenella M Pupa; Carla De Giovanni; Michela Spadaro; Claudia Curcio; Pier-Luigi Lollini; Piero Musiani; Guido Forni; Federica Cavallo
Electroporated DNA vaccine clears away multifocal mammary carcinomas in her-2/neu transgenic mice.
Cancer research 2004;64(8):2858-64.
2004: Elena Quaglino; Simona Rolla; Manuela Iezzi; Michela Spadaro; Piero Musiani; Carla De Giovanni; Pier-Luigi Lollini; Stefania Lanzardo; Guido Forni; Remo Sanges; Stefania Crispi; Pasquale De Luca; Raffaele A Calogero; Federica Cavallo
Concordant morphologic and gene expression data show that a vaccine halts HER-2/neu preneoplastic lesions.
The Journal of clinical investigation 2004;113(5):709-17.
2003: Patrizia Nanni; Giordano Nicoletti; Carla De Giovanni; Lorena Landuzzi; Emma Di Carlo; Manuela Iezzi; Cinzia Ricci; Annalisa Astolfi; Stefania Croci; Francesco Marangoni; Piero Musiani; Guido Forni; Pier-Luigi Lollini
Prevention of HER-2/neu transgenic mammary carcinoma by tamoxifen plus interleukin 12.
International journal of cancer. Journal international du cancer 2003;105(3):384-9.
2003: Patrizia Nanni; Giordano Nicoletti; Carla De Giovanni; Stefania Croci; Annalisa Astolfi; Lorena Landuzzi; Emma Di Carlo; Manuela Iezzi; Piero Musiani; Pier-Luigi Lollini
Development of rhabdomyosarcoma in HER-2/neu transgenic p53 mutant mice.
Cancer research 2003;63(11):2728-32.
2003: Paola Cappello; Frederic Triebel; Manuela Iezzi; Cristiana Caorsi; Elena Quaglino; Pier-Luigi Lollini; Augusto Amici; Emma Di Carlo; Piero Musiani; Mirella Giovarelli; Guido Forni
LAG-3 enables DNA vaccination to persistently prevent mammary carcinogenesis in HER-2/neu transgenic BALB/c mice.
Cancer research 2003;63(10):2518-25.
2002: Mauro Piantelli; Stefano Iacobelli; Giovanni Almadori; Manuela Iezzi; Nicola Tinari; Clara Natoli; Gabriella Cadoni; Libero Lauriola; Franco O Ranelletti
Lack of expression of galectin-3 is associated with a poor outcome in node-negative patients with laryngeal squamous-cell carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2002;20(18):3850-6.
2001: Emma Di Carlo; Manuela Iezzi; Tania Pannellini; F Zaccardi; Andrea Modesti; Guido Forni; Piero Musiani
Neutrophils in anti-cancer immunological strategies: old players in new games.
Journal of hematotherapy & stem cell research 2001;10(6):739-48.
2000: MG Diodoro; Emma Di Carlo; R Zappacosta; Manuela Iezzi; Anna Coletti; Andrea Modesti; Tommaso D'Antuono; Guido Forni; Piero Musiani
Salivary carcinoma in HER-2/neu transgenic male mice: an angiogenic switch is not required for tumor onset and progression.
International journal of cancer. Journal international du cancer 2000;88(3):329-35.