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Osamu Igarashi

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Rieko Yachi; Yoshinori Aoki; Osamu Igarashi; Taisuke Koike; Chie Muto; Natsuki Ohtaka; Chikako Kiyose
Effects of tocotrienol on tumor necrosis factor-α/d-galactosamine-induced steatohepatitis in rats.
Takahiro Nagatake; Satoshi Fukuyama; Dong-Young Kim; Kaoru Goda; Osamu Igarashi; Shintaro Sato; Tomonori Nochi; Hiroshi Sagara; Yoshifumi Yokota; Anton M Jetten; Tsuneyasu Kaisho; Shizuo Akira; Hitomi Mimuro; Chihiro Sasakawa; Yoshinori Fukui; Kohtaro Fujihashi; Taishin Akiyama; Jun-Ichiro Inoue; Josef M Penninger; Jun Kunisawa; Hiroshi Kiyono
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
Kazutaka Terahara; Masato Yoshida; Osamu Igarashi; Tomonori Nochi; Gemilson Soares Pontes; Koji Hase; Hiroshi Ohno; Shiho Kurokawa; Mio Mejima; Naoko Takayama; Yoshikazu Yuki; Anson W Lowe; Hiroshi Kiyono
Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.

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All Publications

2013: Rieko Yachi; Yoshinori Aoki; Osamu Igarashi; Taisuke Koike; Chie Muto; Natsuki Ohtaka; Chikako Kiyose
Effects of tocotrienol on tumor necrosis factor-α/d-galactosamine-induced steatohepatitis in rats.
Journal of clinical biochemistry and nutrition 2013;52(2):146-53.
2009: Takahiro Nagatake; Satoshi Fukuyama; Dong-Young Kim; Kaoru Goda; Osamu Igarashi; Shintaro Sato; Tomonori Nochi; Hiroshi Sagara; Yoshifumi Yokota; Anton M Jetten; Tsuneyasu Kaisho; Shizuo Akira; Hitomi Mimuro; Chihiro Sasakawa; Yoshinori Fukui; Kohtaro Fujihashi; Taishin Akiyama; Jun-Ichiro Inoue; Josef M Penninger; Jun Kunisawa; Hiroshi Kiyono
Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity.
The Journal of experimental medicine 2009;206(11):2351-64.
2008: Kazutaka Terahara; Masato Yoshida; Osamu Igarashi; Tomonori Nochi; Gemilson Soares Pontes; Koji Hase; Hiroshi Ohno; Shiho Kurokawa; Mio Mejima; Naoko Takayama; Yoshikazu Yuki; Anson W Lowe; Hiroshi Kiyono
Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(12):7840-6.
2008: Tomomi Hashizume; Atsushi Togawa; Tomonori Nochi; Osamu Igarashi; Mi-Na Kweon; Hiroshi Kiyono; Masafumi Yamamoto
Peyer's patches are required for intestinal immunoglobulin A responses to Salmonella spp.
Infection and immunity 2008;76(3):927-34.
2008: Sun-Young Chang; Hye-Ran Cha; Satoshi Uematsu; Shizuo Akira; Osamu Igarashi; Hiroshi Kiyono; Mi-Na Kweon
Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(3):1609-18.
2007: Tomonori Nochi; Yoshikazu Yuki; Akiko Matsumura; Mio Mejima; Kazutaka Terahara; Dong-Young Kim; Satoshi Fukuyama; Kiyoko Iwatsuki-Horimoto; Yoshihiro Kawaoka; Tomoko Kohda; Shunji Kozaki; Osamu Igarashi; Hiroshi Kiyono
A novel M cell-specific carbohydrate-targeted mucosal vaccine effectively induces antigen-specific immune responses.
The Journal of experimental medicine 2007;204(12):2789-96.
2007: Harumi Uto-Kondo; Mariko Tani; Chikako Kiyose; Mika Usuda; Chie Taguchi; Maiko Hasegawa; Naoko Machida; Yoshimi Kishimoto; Hisako Saito; Tadahiko Ueda; Osamu Igarashi; Kazuo Kondo
gamma-Tocopherol Accelerated Sodium Excretion in a Dose-Dependent Manner in Rats with a High Sodium Intake.
Journal of clinical biochemistry and nutrition 2007;41(3):211-7.
2007: Harumi Uto-Kondo; Chikako Kiyose; Reiko Ohmori; Hisako Saito; Chie Taguchi; Yoshimi Kishimoto; Naoko Machida; Maiko Hasegawa; Eri Yoshioka; Emi Saita; Yumiko Hirata; Osamu Igarashi; Kazuo Kondo
The coantioxidative effects of carboxyethyl-6-hydroxychromans and alpha-Tocopherol.
Journal of nutritional science and vitaminology 2007;53(4):301-5.
2007: Naoko Takayama; Osamu Igarashi; Mi-Na Kweon; Hiroshi Kiyono
Regulatory role of Peyer's patches for the inhibition of OVA-induced allergic diarrhea.
Clinical immunology (Orlando, Fla.) 2007;123(2):199-208.
2007: Akiko Ogawa; Naohisa Nosaka; Michio Kasai; Toshiaki Aoyama; Mitsuko Okazaki; Osamu Igarashi; Kazuo Kondo
Dietary medium- and long-chain triacylglycerols accelerate diet-induced thermogenesis in humans.
Journal of oleo science 2007;56(6):283-7.
2004: Mayumi Ueta; Tomonori Nochi; Myoung Ho Jang; Eun Jeong Park; Osamu Igarashi; Ayako Hino; Satoshi Kawasaki; Takashi Shikina; Takachika Hiroi; Shigeru Kinoshita; Hiroshi Kiyono
Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium.
Journal of immunology (Baltimore, Md. : 1950) 2004;173(5):3337-47.
2004: Harumi Uto; Chikako Kiyose; Hisako Saito; Tadahiko Ueda; Takaharu Nakamijra; Osamu Igarashi; Kazuo Kondo
Gamma-tocopherol enhances sodium excretion as a natriuretic hormone precursor.
Journal of nutritional science and vitaminology 2004;50(4):277-82.
2003: Aya Mizukuchi; Rumi Umeda-Sawada; Osamu Igarashi
Effect of dietary fat level and sesamin on the polyunsaturated fatty acid metabolism in rats.
Journal of nutritional science and vitaminology 2003;49(5):320-6.
2003: Hisako Saito; Chikako Kiyose; Hiroyuki Yoshimura; Tadahiko Ueda; Kazuo Kondo; Osamu Igarashi
Gamma-tocotrienol, a vitamin E homolog, is a natriuretic hormone precursor.
Journal of lipid research 2003;44(8):1530-5.
2003: Naohisa Nosaka; Hideaki Maki; Yoshie Suzuki; Hirofumi Haruna; Atsushi Ohara; Michio Kasai; Hiroaki Tsuji; Toshiaki Aoyama; Mitsuko Okazaki; Osamu Igarashi; Kazuo Kondo
Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans.
Journal of atherosclerosis and thrombosis 2003;10(5):290-8.
2003: Michio Kasai; Hideaki Maki; Naohisa Nosaka; Toshiaki Aoyama; Katsuhiko Ooyama; Harumi Uto; Mitsuko Okazaki; Osamu Igarashi; Kazuo Kondo
Effect of medium-chain triglycerides on the postprandial triglyceride concentration in healthy men.
Bioscience, biotechnology, and biochemistry 2003;67(1):46-53.
2001: Toshiki Tamura; Osamu Igarashi; Ayako Hino; H Yamane; Shin Aizawa; Takuma Kato; H Nariuchi
Impairment in the expression and activity of Fyn during differentiation of naive CD4+ T cells into the Th2 subset.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(4):1962-9.
2001: Rumi Umeda-Sawada; M Ogawa; M Nakamura; Osamu Igarashi
Effect of sesamin on mitochondrial and peroxisomal beta-oxidation of arachidonic and eicosapentaenoic acids in rat liver.
Lipids 2001;36(5):483-9.
2001: Chikako Kiyose; Hiroaki Saito; K Kaneko; Keisuke Hamamura; Mitsugu Tomioka; Takuya Ueda; Osamu Igarashi
Alpha-tocopherol affects the urinary and biliary excretion of 2,7,8-trimethyl-2 (2'-carboxyethyl)-6-hydroxychroman, gamma-tocopherol metabolite, in rats.
Lipids 2001;36(5):467-72.
2001: Chikako Kiyose; Hiroaki Saito; Takuya Ueda; Osamu Igarashi
Simultaneous determination of alpha-, gamma-tocopherol and their quinones in rats plasma and tissues using reversed-phase high-performance liquid chromatography.
Journal of nutritional science and vitaminology 2001;47(2):102-7.
2001: T T Yamanushi; T Ichinose; H Seto; Masaru Sagai; M I Torii; Osamu Igarashi
The effect of dietary carotenoids on lung tumorigenesis induced by intratracheally instillated diesel exhaust particles.
Journal of nutritional science and vitaminology 2001;47(1):32-9.
2000: H Yamane; Osamu Igarashi; Takuma Kato; H Nariuchi
Positive and negative regulation of IL-12 receptor expression of naive CD4(+) T cells by CD28/CD152 co-stimulation.
European journal of immunology 2000;30(11):3171-80.
2000: Toshiki Tamura; T Kunimatsu; S T Yee; Osamu Igarashi; Masanori Utsuyama; S Tanaka; Katsuiku Hirokawa; S i Miyazaki; H Nariuchi
Molecular mechanism of the impairment in activation signal transduction in CD4(+) T cells from old mice.
International immunology 2000;12(8):1205-15.
2000: K Kaneko; Chikako Kiyose; Takuya Ueda; H Ichikawa; Osamu Igarashi
Studies of the metabolism of alpha-tocopherol stereoisomers in rats using [5-methyl-(14)C]SRR- and RRR-alpha-tocopherol.
Journal of lipid research 2000;41(3):357-67.
2000: P S Tam; Rumi Umeda-Sawada; T Yaguchi; K Akimoto; Yoshinobu Kiso; Osamu Igarashi
The metabolism and distribution of docosapentaenoic acid (n-6) in rats and rat hepatocytes.
Lipids 2000;35(1):71-5.
2000: Ayako Hino; Osamu Igarashi; Y I Tagawa; Yoichiro Iwakura; H Nariuchi
Interferon gamma priming is not critical for IL-12 production of murine spleen cells.
Cytokine 2000;12(1):12-20.
1999: Osamu Igarashi; Chikako Kiyose
Physiological functions of vitamin E and biodiscrimination of its stereoisomers.
Anticancer research 1999;19(5A):3783-5.
1999: Rumi Umeda-Sawada; M Ogawa; Osamu Igarashi
The metabolism and distribution of sesame lignans (sesamin and episesamin) in rats.
Lipids 1999;34(6):633-7.
1999: Chikako Kiyose; K Kaneko; Ryuji Muramatsu; Takuya Ueda; Osamu Igarashi
Simultaneous determination of RRR- and SRR-alpha-tocopherols and their quinones in rat plasma and tissues by using chiral high-performance liquid chromatography.
Lipids 1999;34(4):415-22.
1998: Rumi Umeda-Sawada; M Ogawa; Osamu Igarashi
The metabolism and n-6/n-3 ratio of essential fatty acids in rats: effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin).
Lipids 1998;33(6):567-72.
1998: Osamu Igarashi; H Yamane; Shinobu Imajoh-Ohmi; H Nariuchi
IL-12 receptor (IL-12R) expression and accumulation of IL-12R beta 1 and IL-12R beta 2 mRNAs in CD4+ T cells by costimulation with B7-2 molecules.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(4):1638-46.
1997: A Hosomi; M Arita; Y Sato; Chikako Kiyose; Takuya Ueda; Osamu Igarashi; Hiroyuki Arai; Kenji Inoue
Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs.
FEBS letters 1997;409(1):105-8.
1997: Chikako Kiyose; Ryuji Muramatsu; Yoshiyuki Kameyama; Takuya Ueda; Osamu Igarashi
Biodiscrimination of alpha-tocopherol stereoisomers in humans after oral administration.
The American journal of clinical nutrition 1997;65(3):785-9.
1997: Takuma Kato; T Morokata; Osamu Igarashi; S T Yee; Manabu Inobe; Toshimitsu Uede; Masahiko Azuma; Ko Okumura; H Nariuchi
Costimulatory effect of IL-12 on the activation of naive, memory CD4+ T cells, and Th1 clone.
Cellular immunology 1997;176(1):50-8.
1996: Rumi Umeda-Sawada; M Ogawa; Y Okada; Osamu Igarashi
Effect of sesamin on the composition of eicosapentaenoic acid in liver and on its lymphatic absorption in rats.
Bioscience, biotechnology, and biochemistry 1996;60(12):2071-2.
1996: Osamu Igarashi; T Yanagida; Masahiko Azuma; K Okumura; H Nariuchi
B7-1 synergizes with interleukin-12 in interleukin-2 receptor alpha expression by mouse T helper 1 clones.
European journal of immunology 1996;26(2):300-6.
1995: Rumi Umeda-Sawada; N Takahashi; Osamu Igarashi
Interaction of sesamin and eicosapentaenoic acid against delta 5 desaturation and n-6/n-3 ratio of essential fatty acids in rat.
Bioscience, biotechnology, and biochemistry 1995;59(12):2268-73.
1995: T Tamura; H Nakano; H Nagase; T Morokata; Osamu Igarashi; Y Oshimi; S Miyazaki; H Nariuchi
Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. Roles of protein tyrosine kinases in the signal for IL-2 and IL-4 production.
Journal of immunology (Baltimore, Md. : 1950) 1995;155(10):4692-701.
1995: Chikako Kiyose; Ryuji Muramatsu; Y Fujiyama-Fujiwara; Takuya Ueda; Osamu Igarashi
Biodiscrimination of alpha-tocopherol stereoisomers during intestinal absorption.
Lipids 1995;30(11):1015-8.
1995: T Morokata; Takuma Kato; Osamu Igarashi; H Nariuchi
Mechanism of enhanced antigen presentation by B cells activated with anti-mu plus interferon-gamma: role of B7-2 in the activation of naive and memory CD4+ T cells.
European journal of immunology 1995;25(7):1992-8.
1995: Chikako Kiyose; Ryuji Muramatsu; Takuya Ueda; Osamu Igarashi
Change in the distribution of alpha-tocopherol stereoisomers in rats after intravenous administration.
Bioscience, biotechnology, and biochemistry 1995;59(5):791-5.
1995: Y Fujiyama-Fujiwara; Rumi Umeda-Sawada; M Kuzuyama; Osamu Igarashi
Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid-rich diet.
Journal of nutritional science and vitaminology 1995;41(2):217-25.
1995: T Yamanushi; Osamu Igarashi
The mobilization and tissue distribution of beta-carotene in the rat by the venous injection method.
Journal of nutritional science and vitaminology 1995;41(2):169-77.
1994: T Yanagida; Takuma Kato; Osamu Igarashi; Tomomi Inoue; H Nariuchi
Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(10):4919-28.
1993: Osamu Igarashi
[Vitamin K].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(4):910-8.
1992: Y Fujiyama-Fujiwara; R Umeda; Osamu Igarashi
Metabolism of arachidonic, eicosapentaenoic, and docosahexaenoic acids in HepG2 cells and rat hepatocytes.
Journal of nutritional science and vitaminology 1992;38(4):329-34.
1992: Y Fujiyama-Fujiwara; R Umeda; Osamu Igarashi
Effects of sesamin and curcumin on delta 5-desaturation and chain elongation of polyunsaturated fatty acid metabolism in primary cultured rat hepatocytes.
Journal of nutritional science and vitaminology 1992;38(4):353-63.
1991: Osamu Igarashi; Y Yonekawa; Y Fujiyama-Fujihara
Synergistic action of vitamin E and vitamin C in vivo using a new mutant of Wistar-strain rats, ODS, unable to synthesize vitamin C.
Journal of nutritional science and vitaminology 1991;37(4):359-69.
1990: K H Ha; Osamu Igarashi
The oxidation products from two kinds of tocopherols co-existing in autoxidation system of methyl linoleate.
Journal of nutritional science and vitaminology 1990;36(4):411-21.
1989: Y Fujiyama-Fujiwara; C Ohmori; Osamu Igarashi
Metabolism of gamma-linolenic acid in primary cultures of rat hepatocytes and in Hep G2 cells.
Journal of nutritional science and vitaminology 1989;35(6):597-611.
1989: Takatoshi Ishikawa; Y Fujiyama; Osamu Igarashi; M Morino; N Tada; A Kagami; T Sakamoto; M Nagano; H Nakamura
Effects of gammalinolenic acid on plasma lipoproteins and apolipoproteins.
Atherosclerosis 1989;75(2-3):95-104.