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Marc Iglarz

Research Profile

Chemicals & Drugs

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Anatomy

Physiology

Vascular Resistance

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Publications

TOP 3
Martin H Bolli; Christoph Boss; Stephan Buchmann; Daniel Bur; Martine Clozel; Walter Fischli; Patrick Hess; Marc Iglarz; Solange Meyer; Josiane Rein; Markus Rey; Alexander Treiber; Christoph A Binkert; Thomas Weller
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Marc Iglarz; Martine Clozel
At the heart of tissue: endothelin system and end-organ damage.
MyoungKun Jeoung; Sungeun Lee; Hee-Kyung Hawng; Yong-Pil Cheon; Youn Kyung Jeong; Myung Chan Gye; Marc Iglarz; Chemyong Ko; Phillip J Bridges
Identification of a novel role for endothelins within the oviduct.

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All Publications

2012: Martin H Bolli; Christoph Boss; Stephan Buchmann; Daniel Bur; Martine Clozel; Walter Fischli; Patrick Hess; Marc Iglarz; Solange Meyer; Josiane Rein; Markus Rey; Alexander Treiber; Christoph A Binkert; Thomas Weller
The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.
Journal of medicinal chemistry 2012;55(17):7849-61.
2010: Marc Iglarz; Martine Clozel
At the heart of tissue: endothelin system and end-organ damage.
Clinical science (London, England : 1979) 2010;119(11):453-63.
2010: MyoungKun Jeoung; Sungeun Lee; Hee-Kyung Hawng; Yong-Pil Cheon; Youn Kyung Jeong; Myung Chan Gye; Marc Iglarz; Chemyong Ko; Phillip J Bridges
Identification of a novel role for endothelins within the oviduct.
Endocrinology 2010;151(6):2858-67.
2010: Carmine Savoia; Téni G Ebrahimian; Catherine A Lemarié; Pierre Paradis; Marc Iglarz; Farhad Amiri; Danesh Javeshgani; Ernesto L Schiffrin
Countervailing vascular effects of rosiglitazone in high cardiovascular risk mice: role of oxidative stress and PRMT-1.
Clinical science (London, England : 1979) 2010;118(9):583-92.
2008: Marc Iglarz; Christoph Binkert; Keith Morrison; Walter Fischli; John Gatfield; Alexander Treiber; Thomas Weller; Martin H Bolli; Christoph Boss; Stephan Buchmann; Bruno Capeleto; Patrick Hess; Changbin Qiu; Martine Clozel
Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist.
The Journal of pharmacology and experimental therapeutics 2008;327(3):736-45.
2008: Qian Pu; Pascal Brassard; Danesh M Javeshghani; Marc Iglarz; Randy L Webb; Farhad Amiri; Ernesto L Schiffrin
Effects of combined AT1 receptor antagonist/NEP inhibitor on vascular remodeling and cardiac fibrosis in SHRSP.
Journal of hypertension 2008;26(2):322-33.
2007: Marc Iglarz; Martine Clozel
Mechanisms of ET-1-induced endothelial dysfunction.
Journal of cardiovascular pharmacology 2007;50(6):621-8.
2007: Linah Al-Alem; Phillip J Bridges; Wen Su; Ming C Gong; Marc Iglarz; Chemyong Ko
Endothelin-2 induces oviductal contraction via endothelin receptor subtype A in rats.
The Journal of endocrinology 2007;193(3):383-91.
2007: Carolina De Ciuceis; Farhad Amiri; Marc Iglarz; Jeffrey S Cohn; Rhian M Touyz; Ernesto L Schiffrin
Synergistic vascular protective effects of combined low doses of PPARalpha and PPARgamma activators in angiotensin II-induced hypertension in rats.
British journal of pharmacology 2007;151(1):45-53.
2006: Martine Clozel; Patrick Hess; Markus Rey; Marc Iglarz; Christoph A Binkert; Changbin Qiu
Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats.
Experimental biology and medicine (Maywood, N.J.) 2006;231(6):967-73.
2006: Chemyong Ko; Mary C Gieske; Linah Al-Alem; Yunkyung Hahn; Wen Su; Ming C Gong; Marc Iglarz; Yongbum Koo
Endothelin-2 in ovarian follicle rupture.
Endocrinology 2006;147(4):1770-9.
2005: Pierre Beaucage; Marc Iglarz; Marc J Servant; Rhian M Touyz; Pierre Moreau
Position of Src tyrosine kinases in the interaction between angiotensin II and endothelin in in vivo vascular protein synthesis.
Journal of hypertension 2005;23(2):329-35.
2004: Farhad Amiri; Agostino Virdis; Mario Fritsch Neves; Marc Iglarz; Nabil G Seidah; Rhian M Touyz; Timothy L Reudelhuber; Ernesto L Schiffrin
Endothelium-restricted overexpression of human endothelin-1 causes vascular remodeling and endothelial dysfunction.
Circulation 2004;110(15):2233-40.
2004: Marc Iglarz; Rhian M Touyz; Emilie C Viel; Farhad Amiri; Ernesto L Schiffrin
Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction wtih the renin-angiotension system.
American journal of hypertension 2004;17(7):597-603.
2004: Dierk Endemann; Rhian M Touyz; Marc Iglarz; Carmine Savoia; Ernesto L Schiffrin
Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats.
Hypertension 2004;43(6):1252-7.
2004: C Devaux; Marc Iglarz; Vincent RICHARD; Paul Mulder; Daniel Henrion; Sylvanie Renet; Jean-Paul Henry; Christian Thuillez
Chronic decrease in flow contributes to heart failure-induced endothelial dysfunction in rats.
Clinical and experimental pharmacology & physiology 2004;31(5-6):302-5.
2003: Ernesto L Schiffrin; Farhad Amiri; Karim Benkirane; Marc Iglarz; Quy N Diep
Peroxisome proliferator-activated receptors: vascular and cardiac effects in hypertension.
Hypertension 2003;42(4):664-8.
2003: Marc Iglarz; Rhian M Touyz; Emilie C Viel; Pierre Paradis; Farhad Amiri; Quy N Diep; Ernesto L Schiffrin
Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertension.
Hypertension 2003;42(4):737-43.
2003: Agostino Virdis; Marc Iglarz; Mario Fritsch Neves; Farhad Amiri; Rhian M Touyz; Rima Rozen; Ernesto L Schiffrin
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(8):1352-7.
2003: Marc Iglarz; Ernesto L Schiffrin
Role of endothelin-1 in hypertension.
Current hypertension reports 2003;5(2):144-8.
2003: Marc Iglarz; Rhian M Touyz; Farhad Amiri; Marie-France Lavoie; Quy N Diep; Ernesto L Schiffrin
Effect of peroxisome proliferator-activated receptor-alpha and -gamma activators on vascular remodeling in endothelin-dependent hypertension.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):45-51.
2002: Jean-Sébastien Silvestre; Radia Tamarat; Takaaki Senbonmatsu; Toshihiro Icchiki; Téni G Ebrahimian; Marc Iglarz; Sandrine Besnard; Micheline Duriez; Tadashi Inagami; Bernard I Lévy
Antiangiogenic effect of angiotensin II type 2 receptor in ischemia-induced angiogenesis in mice hindlimb.
Circulation research 2002;90(10):1072-9.
2002: Marc Iglarz; Joelle Benessiano; Ivan Philip; Sandrine Vuillaumier-Barrot; sigismond lasocki; Ulrik Hvass; Geneviève Durand; Jean-Marie Desmonts; Bernard I Lévy; Daniel Henrion
Preproendothelin-1 gene polymorphism is related to a change in vascular reactivity in the human mammary artery in vitro.
Hypertension 2002;39(2):209-13.
2002: sigismond lasocki; Marc Iglarz; Pierre-François Seince; Sandrine Vuillaumier-Barrot; Eric Vicaut; Daniel Henrion; Bernard Levy; Jean-Marie Desmonts; Ivan Philip; Joëlle Bénessiano
Involvement of renin-angiotensin system in pressure-flow relationship: role of angiotensin-converting enzyme gene polymorphism.
Anesthesiology 2002;96(2):271-5.
2002: Daniel Henrion; Joelle Benessiano; Marc Iglarz; Ivan Philip; Bernard I Levy
Genetic determinants of vascular reactivity.
Current hypertension reports 2002;4(1):41-8.
2001: Marc Iglarz; Jean-Sébastien Silvestre; Micheline Duriez; Daniel Henrion; Bernard I Lévy
Chronic blockade of endothelin receptors improves ischemia-induced angiogenesis in rat hindlimbs through activation of vascular endothelial growth factor-no pathway.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(10):1598-603.
1999: Daniel Henrion; Joelle Benessiano; Ivan Philip; Sandrine Vuillaumier-Barrot; Marc Iglarz; Gaetan Plantefève; D Chatel; Ulrik Hvass; Geneviève Durand; Jean-Marie Desmonts; Philippe Amouyel; Bernard I Lévy
The deletion genotype of the angiotensin I-converting enzyme is associated with an increased vascular reactivity in vivo and in vitro.
Journal of the American College of Cardiology 1999;34(3):830-6.
1999: Daniel Henrion; Marc Iglarz; Bernard I Lévy
Chronic endothelin-1 improves nitric oxide-dependent flow-induced dilation in resistance arteries from normotensive and hypertensive rats.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2148-53.
1999: Marc Iglarz; Bernard I Lévy; Daniel Henrion
Prolonged blockade of endothelin ET(A) receptors decreases vascular reactivity in the aorta of spontaneously hypertensive rats in vitro.
Journal of cardiovascular pharmacology 1999;34(3):354-8.
1998: Marc Iglarz; Bernard I Lévy; Daniel Henrion
Chronic endothelin-1-induced changes in vascular reactivity in rat resistance arteries and aorta.
European journal of pharmacology 1998;359(1):69-75.
1998: Marc Iglarz; Khalid Matrougui; Bernard I Lévy; Daniel Henrion
Chronic blockade of endothelin ETA receptors improves flow dependent dilation in resistance arteries of hypertensive rats.
Cardiovascular research 1998;39(3):657-64.