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Yasuo Ihara

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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TOP 3
Chae Young Chan; Lee Sukmook; Heo Kyun; Ha Sang Hoon; Jung Yonwoo; Kim Jong Hyun; Ihara Yasuo; Suh Pann-Ghill; Ryu Sung Ho
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.
Kimura Mariko; Ihara Yasuo
Replicator-dynamics models of sexual conflict.
Takei Norihiro; Miyashita Akinori; Tsukie Tamao; Arai Hiroyuki; Asada Takashi; Imagawa Masaki; Shoji Mikio; Higuchi Susumu; Urakami Katsuya; Kimura Hideo; Kakita Akiyoshi; Takahashi Hitoshi; Tsuji Shoji; Kanazawa Ichiro; Ihara Yasuo; Odani Shoji; Kuwano Ryozo;
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.

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All Publications

2009: Chae Young Chan; Lee Sukmook; Heo Kyun; Ha Sang Hoon; Jung Yonwoo; Kim Jong Hyun; Ihara Yasuo; Suh Pann-Ghill; Ryu Sung Ho
Collapsin response mediator protein-2 regulates neurite formation by modulating tubulin GTPase activity.
Cellular signalling 2009;21(12):1818-26.
2009: Kimura Mariko; Ihara Yasuo
Replicator-dynamics models of sexual conflict.
Journal of theoretical biology 2009;260(1):90-7.
2009: Takei Norihiro; Miyashita Akinori; Tsukie Tamao; Arai Hiroyuki; Asada Takashi; Imagawa Masaki; Shoji Mikio; Higuchi Susumu; Urakami Katsuya; Kimura Hideo; Kakita Akiyoshi; Takahashi Hitoshi; Tsuji Shoji; Kanazawa Ichiro; Ihara Yasuo; Odani Shoji; Kuwano Ryozo;
Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese.
Genomics 2009;93(5):441-8.
2009: Miyashita Akinori; Arai Hiroyuki; Asada Takashi; Imagawa Masaki; Shoji Mikio; Higuchi Susumu; Urakami Katsuya; Toyabe Shinichi; Akazawa Kohei; Kanazawa Ichiro; Ihara Yasuo; Kuwano Ryozo
GAB2 is not associated with late-onset Alzheimer's disease in Japanese.
European journal of human genetics : EJHG 2009;17(5):682-6.
2009: Kurokawa Shun; Ihara Yasuo
Emergence of cooperation in public goods games.
Proceedings. Biological sciences / The Royal Society 2009;276(1660):1379-84.
2008: Osawa Satoko; Funamoto Satoru; Nobuhara Mika; Wada-Kakuda Satoko; Shimojo Masafumi; Yagishita Sosuke; Ihara Yasuo
Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states.
The Journal of biological chemistry 2008;283(28):19283-92.
2008: Shimojo Masafumi; Sahara Naruhiko; Mizoroki Tatsuya; Funamoto Satoru; Morishima-Kawashima Maho; Kudo Takashi; Takeda Masatoshi; Ihara Yasuo; Ichinose Hiroshi; Takashima Akihiko
Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.
The Journal of biological chemistry 2008;283(24):16488-96.
2008: Ihara Yasuo
Spread of costly prestige-seeking behavior by social learning.
Theoretical population biology 2008;73(1):148-57.
2008: Yagishita Sosuke; Morishima-Kawashima Maho; Ishiura Shoichi; Ihara Yasuo
Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains.
The Journal of biological chemistry 2008;283(2):733-8.
2007: Miyashita Akinori; Arai Hiroyuki; Asada Takashi; Imagawa Masaki; Matsubara Etsuro; Shoji Mikio; Higuchi Susumu; Urakami Katsuya; Kakita Akiyoshi; Takahashi Hitoshi; Toyabe Shinichi; Akazawa Kohei; Kanazawa Ichiro; Ihara Yasuo; Kuwano Ryozo;
Genetic association of CTNNA3 with late-onset Alzheimer's disease in females.
Human molecular genetics 2007;16(23):2854-69.
2007: Ihara Yasuo
[Overview on Alzheimer's disease]
Rinsho shinkeigaku = Clinical neurology 2007;47(11):902-4.
2007: Sato Toru; Diehl Thekla S; Narayanan Saravanakumar; Funamoto Satoru; Ihara Yasuo; De Strooper Bart; Steiner Harald; Haass Christian; Wolfe Michael S
Active gamma-secretase complexes contain only one of each component.
The Journal of biological chemistry 2007;282(47):33985-93.
2007: Seki Motohide; Wakano Joe Yuichiro; Ihara Yasuo
A theoretical study on the evolution of male parental care and female multiple mating: effects of female mate choice and male care bias.
Journal of theoretical biology 2007;247(2):281-96.
2007: Morishima-Kawashima Maho; Han Xianlin; Tanimura Yu; Hamanaka Hiroki; Kobayashi Mariko; Sakurai Takashi; Yokoyama Minesuke; Wada Koji; Nukina Nobuyuki; Fujita Shinobu C; Ihara Yasuo
Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains.
Journal of neurochemistry 2007;101(4):949-58.
2007: Shibata Noriyuki; Kawaguchi Motoko; Uchida Koji; Kakita Akiyoshi; Takahashi Hitoshi; Nakano Ryoichi; Fujimura Harutoshi; Sakoda Saburo; Ihara Yuetsu; Nobukuni Keigo; Takehisa Yasushi; Kuroda Shigetoshi; Kokubo Yasumasa; Kuzuhara Shigeki; Honma Taku; Mochizuki Yoko; Mizutani Tomohiko; Yamada Satoshi; Toi Sono; Sasaki Shoichi; Iwata Makoto; Hirano Asao; Yamamoto Tomoko; Kato Yoichiro; Sawada Tatsuo; Kobayashi Makio
Protein-bound crotonaldehyde accumulates in the spinal cord of superoxide dismutase-1 mutation-associated familial amyotrophic lateral sclerosis and its transgenic mouse model.
Neuropathology : official journal of the Japanese Society of Neuropathology 2007;27(1):49-61.
2006: Iwatsubo Takeshi; Ihara Yasuo; Kanazawa Ichiro
Alzheimer disease research in Japan: public funding.
Nature medicine 2006;12(7):778-9.
2006: Kuwano Ryozo; Miyashita Akinori; Arai Hiroyuki; Asada Takashi; Imagawa Masaki; Shoji Mikio; Higuchi Susumu; Urakami Katsuya; Kakita Akiyoshi; Takahashi Hitoshi; Tsukie Tamao; Toyabe Shinichi; Akazawa Kohei; Kanazawa Ichiro; Ihara Yasuo;
Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease.
Human molecular genetics 2006;15(13):2170-82.
2006: Kakuda Nobuto; Funamoto Satoru; Yagishita Sousuke; Takami Mako; Osawa Satoko; Dohmae Naoshi; Ihara Yasuo
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.
The Journal of biological chemistry 2006;281(21):14776-86.
2006: Yagishita Sousuke; Morishima-Kawashima Maho; Tanimura Yu; Ishiura Shoichi; Ihara Yasuo
DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase.
Biochemistry 2006;45(12):3952-60.
2006: Ihara Yasuo
Neurofibrillary tangles/paired helical filaments (1981-83).
Journal of Alzheimer's disease : JAD 2006;9(3 Suppl):209-17.
2005: Miyasaka Tomohiro; Ding Zhen; Gengyo-Ando Keiko; Oue Miho; Yamaguchi Haruyasu; Mitani Shohei; Ihara Yasuo
Progressive neurodegeneration in C. elegans model of tauopathy.
Neurobiology of disease 2005;20(2):372-83.
2005: Miyasaka Tomohiro; Watanabe Atsushi; Saito Yuko; Murayama Shigeo; Mann David M A; Yamazaki Mineo; Ravid Rivka; Morishima-Kawashima Maho; Nagashima Kazuo; Ihara Yasuo
Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads.
Journal of neuropathology and experimental neurology 2005;64(8):665-74.
2005: Wakano Joe Yuichiro; Ihara Yasuo
Evolution of male parental care and female multiple mating: game-theoretical and two-locus diploid models.
The American naturalist 2005;166(2):E32-44.
2005: Sato Toru; Tanimura Yu; Hirotani Naoko; Saido Takaomi C; Morishima-Kawashima Maho; Ihara Yasuo
Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein.
FEBS letters 2005;579(13):2907-12.
2005: Nakaya Yoshifumi; Yamane Takuya; Shiraishi Hirohisa; Wang Hua-Qin; Matsubara Etsuro; Sato Toru; Dolios Georgia; Wang Rong; De Strooper Bart; Shoji Mikio; Komano Hiroto; Yanagisawa Katsuhiko; Ihara Yasuo; Fraser Paul; St George-Hyslop Peter; Nishimura Masaki
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
The Journal of biological chemistry 2005;280(19):19070-7.
2005: Ihara Yuetsu; Takata Hiroshi; Tanabe Yasuyuki; Nobukuni Keigo; Hayabara Toshiyuki
Influence of repetitive transcranial magnetic stimulation on disease severity and oxidative stress markers in the cerebrospinal fluid of patients with spinocerebellar degeneration.
Neurological research 2005;27(3):310-3.
2005: Shoji Mikio; Kuwano Ryozo; Asada Takasi; Imagawa Masaki; Higuchi Susumu; Urakami Katsuya; Arai Hiroyuki; Ihara Yasuo;
[A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease]
Rinsho shinkeigaku = Clinical neurology 2005;45(2):128-37.
2005: Katsuno T; Morishima-Kawashima M; Saito Y; Yamanouchi H; Ishiura S; Murayama S; Ihara Y
Independent accumulations of tau and amyloid beta-protein in the human entorhinal cortex.
Neurology 2005;64(4):687-92.
2005: Hamaguchi T; Kitamoto T; Sato T; Mizusawa H; Nakamura Y; Noguchi M; Furukawa Y; Ishida C; Kuji I; Mitani K; Murayama S; Kohriyama T; Katayama S; Yamashita M; Yamamoto T; Udaka F; Kawakami A; Ihara Y; Nishinaka T; Kuroda S; Suzuki N; Shiga Y; Arai H; Maruyama M; Yamada M
Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease.
Neurology 2005;64(4):643-8.
2005: Uchida Yutaka; Ohshima Toshio; Sasaki Yukio; Suzuki Hiromi; Yanai Shigeki; Yamashita Naoya; Nakamura Fumio; Takei Kohtaro; Ihara Yasuo; Mikoshiba Katsuhiko; Kolattukudy Papachan; Honnorat Jerome; Goshima Yoshio
Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(2):165-79.
2005: Ihara Yuetsu; Nobukuni Keigo; Takata Hiroshi; Hayabara Toshiyuki
Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Zn-superoxide dismutase mutation.
Neurological research 2005;27(1):105-8.
2005: Qi-Takahara Yue; Morishima-Kawashima Maho; Tanimura Yu; Dolios Georgia; Hirotani Naoko; Horikoshi Yuko; Kametani Fuyuki; Maeda Masahiro; Saido Takaomi C; Wang Rong; Ihara Yasuo
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):436-45.
2004: Funamoto Satoru; Morishima-Kawashima Maho; Tanimura Yu; Hirotani Naoko; Saido Takaomi C; Ihara Yasuo
Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
Biochemistry 2004;43(42):13532-40.
2004: Watanabe Atsushi; Hong Won-Kyoung; Dohmae Naoshi; Takio Koji; Morishima-Kawashima Maho; Ihara Yasuo
Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo.
Journal of neurochemistry 2004;90(6):1302-11.
2004: Oyama Fumitaka; Kotliarova Svetlana; Harada Akihiro; Ito Mamoru; Miyazaki Haruko; Ueyama Yoshito; Hirokawa Nobutaka; Nukina Nobuyuki; Ihara Yasuo
Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau.
The Journal of biological chemistry 2004;279(26):27272-7.
2004: Watanabe Norifumi; Araki Wataru; Chui De-Hua; Makifuchi Takao; Ihara Yasuo; Tabira Takeshi
Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(9):1013-5.
2003: Wada Satoko; Morishima-Kawashima Maho; Qi Yue; Misono Hiroaki; Shimada Yukiko; Ohno-Iwashita Yoshiko; Ihara Yasuo
Gamma-secretase activity is present in rafts but is not cholesterol-dependent.
Biochemistry 2003;42(47):13977-86.
2003: Nakashima Hanae; Terada Seishi; Ishizu Hideki; Tanabe Yasuyuki; Yokota Osamu; Ishihara Takeshi; Takata Hiroshi; Ihara Yuetsu; Hayabara Toshiyuki; Kuroda Shigetoshi
An autopsied case of dementia with Lewy bodies with supranuclear gaze palsy.
Neurological research 2003;25(5):533-7.
2003: Sato Toru; Dohmae Naoshi; Qi Yue; Kakuda Nobuto; Misonou Hiroaki; Mitsumori Rie; Maruyama Hiroko; Koo Edward H; Haass Christian; Takio Koji; Morishima-Kawashima Maho; Ishiura Shoichi; Ihara Yasuo
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein.
The Journal of biological chemistry 2003;278(27):24294-301.
2003: Kanamori Takashi; Nishimaki Kiyomi; Asoh Sadamitsu; Ishibashi Yoshitomo; Takata Iichiro; Kuwabara Tomoko; Taira Kazunari; Yamaguchi Haruyasu; Sugihara Shiro; Yamazaki Tsuneo; Ihara Yasuo; Nakano Kyoko; Matuda Sadayuki; Ohta Shigeo
Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain.
The EMBO journal 2003;22(12):2913-23.
2003: Qi Yue; Morishima-Kawashima Maho; Sato Toru; Mitsumori Rie; Ihara Yasuo
Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
Biochemistry 2003;42(4):1042-52.
2002: Morishima-Kawashima Maho; Ihara Yasuo
Alzheimer's disease: beta-Amyloid protein and tau.
Journal of neuroscience research 2002;70(3):392-401.
2002: Sato Keiko; Murakami Tetsuro; Hamakawa Yoshiyuki; Kamada Hiroshi; Nagano Isao; Shoji Mikio; Takata Hiroshi; Nobukuni Keigo; Ihara Yuetsu; Namba Reiko; Hayabara Toshiyuki; Hirose Shigehisa; Abe Koji
Selective colocalization of transglutaminase-like activity in ubiquitinated intranuclear inclusions of hereditary dentatorubral-pallidoluysian atrophy.
Brain research 2002;952(2):327-30.
2002: Ihara Yasuo
A model for evolution of male parental care and female multiple mating.
The American naturalist 2002;160(2):235-44.
2002: Ihara Yasuo
[gamma secretase]
Seikagaku. The Journal of Japanese Biochemical Society 2002;74(6):449-54.
2002: Lee Sukmook; Kim Jung Hwan; Lee Chang Sup; Kim Jong Hyun; Kim Youndong; Heo Kyun; Ihara Yasuo; Goshima Yoshio; Suh Pann-Ghill; Ryu Sung Ho
Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction.
The Journal of biological chemistry 2002;277(8):6542-9.
2001: Morishima-Kawashima M; Ihara Y
[Recent advances in Alzheimer's disease]
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(11):1297-307.
2001: Utsunomiya I; Ren J; Taguchi K; Ariga T; Tai T; Ihara Y; Miyatake T
Immunohistochemical detection of verotoxin receptors in nervous system.
Brain research. Brain research protocols 2001;8(2):99-103.
2001: Miyasaka T; Morishima-Kawashima M; Ravid R; Kamphorst W; Nagashima K; Ihara Y
Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation.
Journal of neuropathology and experimental neurology 2001;60(9):872-84.
2001: Gu Y; Misonou H; Sato T; Dohmae N; Takio K; Ihara Y
Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch.
The Journal of biological chemistry 2001;276(38):35235-8.
2001: Morishima-Kawashima M; Saido T C; Ihara Y
[Alzheimer's disease and the proteins]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2001;46(11 Suppl):1798-804.
2001: Yamaguchi H; Sugihara S; Ogawa A; Oshima N; Ihara Y
Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects.
Journal of neuropathology and experimental neurology 2001;60(7):731-9.
2001: Oshima N; Morishima-Kawashima M; Yamaguchi H; Yoshimura M; Sugihara S; Khan K; Games D; Schenk D; Ihara Y
Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain.
The American journal of pathology 2001;158(6):2209-18.
2001: Takehisa Y; Ujike H; Ishizu H; Terada S; Haraguchi T; Tanaka Y; Nishinaka T; Nobukuni K; Ihara Y; Namba R; Yasuda T; Nishibori M; Hayabara T; Kuroda S
Familial amyotrophic lateral sclerosis with a novel Leu126Ser mutation in the copper/zinc superoxide dismutase gene showing mild clinical features and lewy body-like hyaline inclusions.
Archives of neurology 2001;58(5):736-40.
2001: Miyasaka T; Morishima-Kawashima M; Ravid R; Heutink P; van Swieten J C; Nagashima K; Ihara Y
Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation.
The American journal of pathology 2001;158(2):373-9.
2001: Yamazaki T; Chang T Y; Haass C; Ihara Y
Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells.
The Journal of biological chemistry 2001;276(6):4454-60.
2001: Ihara Y
PHF and PHF-like fibrils--cause or consequence?
Neurobiology of aging 2001;22(1):123-6.
2000: Ihara Y; Hayabara T; Sasaki K; Kawada R; Nakashima Y; Kuroda S
Relationship between oxidative stress and apoE phenotype in Alzheimer's disease.
Acta neurologica Scandinavica 2000;102(6):346-9.
2000: Morishima-Kawashima M; Oshima N; Ogata H; Yamaguchi H; Yoshimura M; Sugihara S; Ihara Y
Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain.
The American journal of pathology 2000;157(6):2093-9.
2000: Ihara Y
[The current status and perspectives in Alzheimer's disease research]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 2000;37(9):680-6.
2000: Sawamura N; Morishima-Kawashima M; Waki H; Kobayashi K; Kuramochi T; Frosch M P; Ding K; Ito M; Kim T W; Tanzi R E; Oyama F; Tabira T; Ando S; Ihara Y
Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin.
The Journal of biological chemistry 2000;275(36):27901-8.
2000: Saito Y; Kawai M; Inoue K; Sasaki R; Arai H; Nanba E; Kuzuhara S; Ihara Y; Kanazawa I; Murayama S
Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course.
Journal of the neurological sciences 2000;177(1):48-59.
2000: Misonou H; Morishima-Kawashima M; Ihara Y
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.
Biochemistry 2000;39(23):6951-9.
2000: Gu Y; Ihara Y
Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules.
The Journal of biological chemistry 2000;275(24):17917-20.
2000: Gu Y; Hamajima N; Ihara Y
Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522.
Biochemistry 2000;39(15):4267-75.
1999: Kokubo Y; Kuzuhara S; Narita Y; Kikugawa K; Nakano R; Inuzuka T; Tsuji S; Watanabe M; Miyazaki T; Murayama S; Ihara Y
Accumulation of neurofilaments and SOD1-immunoreactive products in a patient with familial amyotrophic lateral sclerosis with I113T SOD1 mutation.
Archives of neurology 1999;56(12):1506-8.
1999: Ihara Y; Chuda M; Kuroda S; Hayabara T
Hydroxyl radical and superoxide dismutase in blood of patients with Parkinson's disease: relationship to clinical data.
Journal of the neurological sciences 1999;170(2):90-5.
1999: Kondo T; Cho S; Ihara Y
[Oxidative stress]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 1999;36(8):530-4.
1999: Funato H; Enya M; Yoshimura M; Morishima-Kawashima M; Ihara Y
Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation.
The American journal of pathology 1999;155(1):23-8.
1999: Matsumura N; Yamazaki T; Ihara Y
Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17).
The American journal of pathology 1999;154(6):1649-56.
1999: Ren J; Utsunomiya I; Taguchi K; Ariga T; Tai T; Ihara Y; Miyatake T
Localization of verotoxin receptors in nervous system.
Brain research 1999;825(1-2):183-8.
1999: Watanabe A; Takio K; Ihara Y
Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau.
The Journal of biological chemistry 1999;274(11):7368-78.
1999: Enya M; Morishima-Kawashima M; Yoshimura M; Shinkai Y; Kusui K; Khan K; Games D; Schenk D; Sugihara S; Yamaguchi H; Ihara Y
Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging.
The American journal of pathology 1999;154(1):271-9.
1998: Morishima-Kawashima M; Ihara Y
The presence of amyloid beta-protein in the detergent-insoluble membrane compartment of human neuroblastoma cells.
Biochemistry 1998;37(44):15247-53.
1998: Murakami N; Oyama F; Gu Y; McLennan I S; Nonaka I; Ihara Y
Accumulation of tau in autophagic vacuoles in chloroquine myopathy.
Journal of neuropathology and experimental neurology 1998;57(7):664-73.
1998: Oyama F; Sawamura N; Kobayashi K; Morishima-Kawashima M; Kuramochi T; Ito M; Tomita T; Maruyama K; Saido T C; Iwatsubo T; Capell A; Walter J; Grünberg J; Ueyama Y; Haass C; Ihara Y
Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Journal of neurochemistry 1998;71(1):313-22.
1998: Funato H; Yoshimura M; Kusui K; Tamaoka A; Ishikawa K; Ohkoshi N; Namekata K; Okeda R; Ihara Y
Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.
The American journal of pathology 1998;152(6):1633-40.
1998: Oyama F; Murakami N; Ihara Y
Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease.
Neuroscience research 1998;31(1):1-8.
1998: Nakabayashi J; Yoshimura M; Morishima-Kawashima M; Funato H; Miyakawa T; Yamazaki T; Ihara Y
Amyloid beta-protein (A beta) accumulation in the putamen and mammillary body during aging and in Alzheimer disease.
Journal of neuropathology and experimental neurology 1998;57(4):343-52.
1998: Funato H; Yoshimura M; Yamazaki T; Saido T C; Ito Y; Yokofujita J; Okeda R; Ihara Y
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.
The American journal of pathology 1998;152(4):983-92.
1998: Yoshida H; Watanabe A; Ihara Y
Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease.
The Journal of biological chemistry 1998;273(16):9761-8.
1998: Gu Y J; Oyama F; Ihara Y
Simultaneous quantification of APP and tau mRNA by RT-PCR.
Shi yan sheng wu xue bao 1998;31(1):1-6.
1998: Yamaguchi H; Sugihara S; Ogawa A; Saido T C; Ihara Y
Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques.
Acta neuropathologica 1998;95(3):217-22.
1998: Yamazaki T; Ihara Y
Effects of specific protease inhibitors on amyloid beta-protein 42 secretion.
Neurobiology of aging 1998;19(1 Suppl):S77-9.
1998: Yanagisawa K; Ihara Y
GM1 ganglioside-bound amyloid beta-protein in Alzheimer's disease brain.
Neurobiology of aging 1998;19(1 Suppl):S65-7.
1997: Ihara Y
[beta-amyloidogenesis]
Rinsho shinkeigaku = Clinical neurology 1997;37(12):1100-1.
1997: Ihara Y; Hayabara T; Sasaki K; Fujisawa Y; Kawada R; Yamamoto T; Nakashima Y; Yoshimune S; Kawai M; Kibata M; Kuroda S
Free radicals and superoxide dismutase in blood of patients with Alzheimer's disease and vascular dementia.
Journal of the neurological sciences 1997;153(1):76-81.
1997: Yanagisawa K; McLaurin J; Michikawa M; Chakrabartty A; Ihara Y
Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta.
FEBS letters 1997;420(1):43-6.
1997: Shinkai Y; Yoshimura M; Morishima-Kawashima M; Ito Y; Shimada H; Yanagisawa K; Ihara Y
Amyloid beta-protein deposition in the leptomeninges and cerebral cortex.
Annals of neurology 1997;42(6):899-908.
1997: Namekata K; Imagawa M; Terashi A; Ohta S; Oyama F; Ihara Y
Association of transferrin C2 allele with late-onset Alzheimer's disease.
Human genetics 1997;101(2):126-9.
1997: Namekata K; Oyama F; Imagawa M; Ihara Y
Human transferrin (Tf): a single mutation at codon 570 determines Tf C1 or Tf C2 variant.
Human genetics 1997;100(3-4):457-8.
1997: Tashiro K; Hasegawa M; Ihara Y; Iwatsubo T
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex.
Neuroreport 1997;8(12):2797-801.
1997: Ihara Y; Kibata M; Hayabara T; Katayama S; Konishi H; Miura K; Kohno M; Kawai M; Yokoi I; Mori A
Free radicals in the cerebrospinal fluid are associated with neurological disorders including mitochondrial encephalomyopathy.
Biochemistry and molecular biology international 1997;42(5):937-47.
1997: Hamano T; Yoshimura M; Yamazaki T; Shinkai Y; Yanagisawa K; Kuriyama M; Ihara Y
Amyloid beta-protein (A beta) accumulation in the leptomeninges during aging and in Alzheimer disease.
Journal of neuropathology and experimental neurology 1997;56(8):922-32.
1997: Yamazaki T; Haass C; Saido T C; Omura S; Ihara Y
Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition.
Biochemistry 1997;36(27):8377-83.
1997: Wild-Bode C; Yamazaki T; Capell A; Leimer U; Steiner H; Ihara Y; Haass C
Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.
The Journal of biological chemistry 1997;272(26):16085-8.
1997: Nobukuni K; Hayakawa N; Namba R; Ihara Y; Sato K; Takada H; Hayabara T; Kawahara S
The influence of long-term treatment with povidone-iodine on thyroid function.
Dermatology (Basel, Switzerland) 1997;195 Suppl 2():69-72.
1996: Funato H; Yoshimura M; Ito Y; Okeda R; Ihara Y
Proliferating cell nuclear antigen (PCNA) expressed in human leptomeninges.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1996;44(11):1261-5.
1996: Gu Y; Oyama F; Ihara Y
Tau is widely expressed in rat tissues.
Journal of neurochemistry 1996;67(3):1235-44.
1996: Kanemaru K; Iwatsubo T; Ihara Y
Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain.
Neuroscience letters 1996;214(2-3):196-8.
1996: Kimura T; Ono T; Takamatsu J; Yamamoto H; Ikegami K; Kondo A; Hasegawa M; Ihara Y; Miyamoto E; Miyakawa T
Sequential changes of tau-site-specific phosphorylation during development of paired helical filaments.
Dementia (Basel, Switzerland) 1996;7(4):177-81.
1996: Nomura Y; Yamanaka Y; Kitamura Y; Arima T; Ohnuki T; Oomura Y; Sasaki K; Nagashima K; Ihara Y
Senescence-accelerated mouse. Neurochemical studies on aging.
Annals of the New York Academy of Sciences 1996;786():410-8.
1996: Iwatsubo T; Yamaguchi H; Fujimuro M; Yokosawa H; Ihara Y; Trojanowski J Q; Lee V M
Lewy bodies: purification from diffuse Lewy body disease brains.
Annals of the New York Academy of Sciences 1996;786():195-205.
1996: Yanagisawa K; Asami-Odaka A; Suzuki N; Ihara Y
Fractionation of amyloid beta-protein (A beta) in Alzheimer's disease and Down's syndrome brains. Presence of membrane-bound A beta.
Annals of the New York Academy of Sciences 1996;786():184-94.
1996: Iwatsubo T; Yamaguchi H; Fujimuro M; Yokosawa H; Ihara Y; Trojanowski J Q; Lee V M
Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.
The American journal of pathology 1996;148(5):1517-29.
1996: Hasegawa M; Jakes R; Crowther R A; Lee V M; Ihara Y; Goedert M
Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein.
FEBS letters 1996;384(1):25-30.
1996: Mann D M; Iwatsubo T; Ihara Y; Cairns N J; Lantos P L; Bogdanovic N; Lannfelt L; Winblad B; Maat-Schieman M L; Rossor M N
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.
The American journal of pathology 1996;148(4):1257-66.
1996: Fukumoto H; Asami-Odaka A; Suzuki N; Shimada H; Ihara Y; Iwatsubo T
Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques.
The American journal of pathology 1996;148(1):259-65.
1996: Morimoto T; Ide T; Ihara Y; Tamura A; Kirino T
Transient ischemia depletes free ubiquitin in the gerbil hippocampal CA1 neurons.
The American journal of pathology 1996;148(1):249-57.
1995: Ihara Y; Mori A; Hayabara T; Kawai M; Namba R; Nobukuni K; Sato K; Kibata M
Superoxide dismutase and free radicals in sporadic amyotrophic lateral sclerosis: relationship to clinical data.
Journal of the neurological sciences 1995;134(1-2):51-6.
1995: Yamamoto H; Hasegawa M; Ono T; Tashima K; Ihara Y; Miyamoto E
Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin.
Journal of biochemistry 1995;118(6):1224-31.
1995: Yanagisawa K; Odaka A; Suzuki N; Ihara Y
GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.
Nature medicine 1995;1(10):1062-6.
1995: Shinkai Y; Yoshimura M; Ito Y; Odaka A; Suzuki N; Yanagisawa K; Ihara Y
Amyloid beta-proteins 1-40 and 1-42(43) in the soluble fraction of extra- and intracranial blood vessels.
Annals of neurology 1995;38(3):421-8.
1995: Ihara Y; Saito K; Yoshimoto S; Hayabara T; Yuki N
[Axonal Guillain-Barré syndrome associated with anti-GalNAc-GD1a antibody subsequent to Campylobacter jejuni (PEN 43) enteritis]
Rinsho shinkeigaku = Clinical neurology 1995;35(8):901-3.
1995: Mann D M; Pickering-Brown S M; Siddons M A; Iwatsubo T; Ihara Y; Asami-Odaka A; Suzuki N
The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype.
Neuroscience letters 1995;196(1-2):105-8.
1995: Morishima-Kawashima M; Hasegawa M; Takio K; Suzuki M; Yoshida H; Watanabe A; Titani K; Ihara Y
Hyperphosphorylation of tau in PHF.
Neurobiology of aging 1995;16(3):365-71; discussion 371-80.
1995: Oyama F; Shimada H; Oyama R; Ihara Y
Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population.
Brain research. Molecular brain research 1995;29(1):92-8.
1995: Iwatsubo T; Mann D M; Odaka A; Suzuki N; Ihara Y
Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome.
Annals of neurology 1995;37(3):294-9.
1995: Saido T C; Iwatsubo T; Mann D M; Shimada H; Ihara Y; Kawashima S
Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques.
Neuron 1995;14(2):457-66.
1995: Uchida Y; Ihara Y
The N-terminal portion of growth inhibitory factor is sufficient for biological activity.
The Journal of biological chemistry 1995;270(7):3365-9.
1995: Ihara Y; Mori A; Hayabara T; Namba R; Nobukuni K; Sato K; Miyata S; Edamatsu R; Liu J; Kawai M
Free radicals, lipid peroxides and antioxidants in blood of patients with myotonic dystrophy.
Journal of neurology 1995;242(3):119-22.
1995: Morishima-Kawashima M; Hasegawa M; Takio K; Suzuki M; Yoshida H; Titani K; Ihara Y
Proline-directed and non-proline-directed phosphorylation of PHF-tau.
The Journal of biological chemistry 1995;270(2):823-9.
1995: Murakami N; Ihara Y; Nonaka I
Chloroquine treated rat: a possible model for Alzheimer's disease.
Muscle & nerve 1995;18(1):123-5.
1995: Mann D M; Iwatsubo T; Fukumoto H; Ihara Y; Odaka A; Suzuki N
Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques.
Acta neuropathologica 1995;90(5):472-7.
1995: Murakami N; Ishiguro K; Ihara Y; Nonaka I; Sugita H; Imahori K
Tau protein immunoreactivity in muscle fibers with rimmed vacuoles differs from that in regenerating muscle fibers.
Acta neuropathologica 1995;90(5):467-71.
1995: Murakami N; Ihara Y; Nonaka I
Muscle fiber degeneration in distal myopathy with rimmed vacuole formation.
Acta neuropathologica 1995;89(1):29-34.
1995: Suemaru S; Suemaru K; Kawai K; Miyata S; Nobukuni K; Ihara Y; Namba R; Urakami K; Hashimoto K
Cerebrospinal fluid corticotropin-releasing hormone in neurodegenerative diseases: reduction in spinocerebellar degeneration.
Life sciences 1995;57(24):2231-5.
1994: Sawa A; Oyama F; Matsushita M; Ihara Y
Molecular diversity at the carboxyl terminus of human and rat tau.
Brain research. Molecular brain research 1994;27(1):111-7.
1994: Ihara Y
Research on Alzheimer's disease in Japan: a personal view on history and present status.
Archives of gerontology and geriatrics 1994;19(2):89-104.
1994: Morishima M; Ihara Y
Posttranslational modifications of tau in paired helical filaments.
Dementia (Basel, Switzerland) 1994;5(5):282-8.
1994: Suzuki N; Iwatsubo T; Odaka A; Ishibashi Y; Kitada C; Ihara Y
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.
The American journal of pathology 1994;145(2):452-60.
1994: Iwatsubo T; Odaka A; Suzuki N; Mizusawa H; Nukina N; Ihara Y
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).
Neuron 1994;13(1):45-53.
1994: Ihara Y; Hayabara T; Namba R; Nobukuni K; Mori A
[Free radical, lipid peroxide and antioxidant in mitochondrial encephalomyopathy]
Rinsho shinkeigaku = Clinical neurology 1994;34(6):593-5.
1994: Saido T C; Yokota M; Maruyama K; Yamao-Harigaya W; Tani E; Ihara Y; Kawashima S
Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus.
The Journal of biological chemistry 1994;269(21):15253-7.
1994: Oyama F; Cairns N J; Shimada H; Oyama R; Titani K; Ihara Y
Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination.
Journal of neurochemistry 1994;62(3):1062-6.
1994: Iwatsubo T; Hasegawa M; Ihara Y
Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics.
Acta neuropathologica 1994;88(2):129-36.
1993: Uéda K; Fukushima H; Masliah E; Xia Y; Iwai A; Yoshimoto M; Otero D A; Kondo J; Ihara Y; Saitoh T
Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(23):11282-6.
1993: Watanabe A; Hasegawa M; Suzuki M; Takio K; Morishima-Kawashima M; Titani K; Arai T; Kosik K S; Ihara Y
In vivo phosphorylation sites in fetal and adult rat tau.
The Journal of biological chemistry 1993;268(34):25712-7.
1993: Yoshida H; Ihara Y
Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau.
Journal of neurochemistry 1993;61(3):1183-6.
1993: Kobayashi H; Uchida Y; Ihara Y; Nakajima K; Kohsaka S; Miyatake T; Tsuji S
Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system.
Brain research. Molecular brain research 1993;19(3):188-94.
1993: Morishima-Kawashima M; Hasegawa M; Takio K; Suzuki M; Titani K; Ihara Y
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments.
Neuron 1993;10(6):1151-60.
1993: Hasegawa M; Watanabe A; Takio K; Suzuki M; Arai T; Titani K; Ihara Y
Characterization of two distinct monoclonal antibodies to paired helical filaments: further evidence for fetal-type phosphorylation of the tau in paired helical filaments.
Journal of neurochemistry 1993;60(6):2068-77.
1993: Oyama F; Shimada H; Oyama R; Titani K; Ihara Y
Beta-amyloid protein precursor and tau mRNA levels versus beta-amyloid plaque and neurofibrillary tangles in the aged human brain.
Journal of neurochemistry 1993;60(5):1658-64.
1993: Suemaru S; Suemaru K; Kawai K; Ihara Y; Hashimoto K
[Cerebrospinal fluid and plasma corticotropin-releasing hormone (CRH) in dentatorubropallidoluysian atrophy (DRPLA)--study in two cases of hereditary DRPLA]
Rinsho shinkeigaku = Clinical neurology 1993;33(4):459-61.
1992: Tsuji S; Kobayashi H; Uchida Y; Ihara Y; Miyatake T
Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease.
The EMBO journal 1992;11(13):4843-50.
1992: Oyama F; Shimada H; Oyama R; Titani K; Ihara Y
A novel correlation between the levels of beta-amyloid protein precursor and tau transcripts in the aged human brain.
Journal of neurochemistry 1992;59(3):1117-25.
1992: Yanagisawa K; Ihara Y; Miyatake T
Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation.
Neuroscience letters 1992;144(1-2):43-5.
1992: Hasegawa M; Morishima-Kawashima M; Takio K; Suzuki M; Titani K; Ihara Y
Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.
The Journal of biological chemistry 1992;267(24):17047-54.
1992: Kohira I; Ishizu H; Shohmori T; Ujike H; Kuroda S; Otsuki S; Ihara Y
[Diffuse reduced uptake in 99m-Tc-HM-PAO SPECT and high level of neuron-specific enolase in cerebrospinal fluid in the early stage of Creutzfeldt-Jakob disease]
No to shinkei = Brain and nerve 1992;44(6):579-82.
1992: Kanemaru K; Takio K; Miura R; Titani K; Ihara Y
Fetal-type phosphorylation of the tau in paired helical filaments.
Journal of neurochemistry 1992;58(5):1667-75.
1992: Watanabe N; Takio K; Hasegawa M; Arai T; Titani K; Ihara Y
Tau 2: a probe for a Ser conformation in the amino terminus of tau.
Journal of neurochemistry 1992;58(3):960-6.
1992: Iwatsubo T; Hasegawa M; Esaki Y; Ihara Y
Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads.
The American journal of pathology 1992;140(2):277-82.
1992: Choi-Miura N H; Ihara Y; Fukuchi K; Takeda M; Nakano Y; Tobe T; Tomita M
SP-40,40 is a constituent of Alzheimer's amyloid.
Acta neuropathologica 1992;83(3):260-4.
1991: Nakamura K; Takahashi T; Tsuyuoka R; Ueda Y; Suzuki A; Okuno Y; Ihara Y; Seko S; Okada T; Kumagai N
Identification of colony-stimulating factor activity in patients with malignant tumors associated with excessive leukocytosis.
Japanese journal of clinical oncology 1991;21(6):395-9.
1991: Ihara Y; Nobukuni K; Namba R; Kamisaka K; Kibata M; Kajinami K; Fujita H; Mabuchi H; Shirabe T; Ohshima K
A family of familial hypercholesterolemia with cerebral infarction and without coronary heart disease. An unusual case with corneal opacity, polyneuropathy and carpal tunnel syndrome in the family: therapy with probucol and tocopherol nicotinate.
Journal of the neurological sciences 1991;106(1):10-8.
1991: Oyama F; Shimada H; Oyama R; Titani K; Ihara Y
Differential expression of beta amyloid protein precursor (APP) and tau mRNA in the aged human brain: individual variability and correlation between APP-751 and four-repeat tau.
Journal of neuropathology and experimental neurology 1991;50(5):560-78.
1991: Uchida Y; Takio K; Titani K; Ihara Y; Tomonaga M
The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein.
Neuron 1991;7(2):337-47.
1991: Ihara Y; Namba R; Nobukuni K; Kawai K; Kuroda S
[Relation between cerebral white matter damage on CT and MRI and clinical data in DRPLA (pseudo-Huntington form)]
Rinsho shinkeigaku = Clinical neurology 1991;31(8):815-20.
1991: Morishima-Kawashima M; Arai T; Ogawara M; Takio K; Titani K; Saitoh T; Kosik K S; Ihara Y
A possible fetal antigen of Mr 70,000 in neurofibrillary tangles.
Brain research 1991;554(1-2):316-20.
1991: Mori H; Ihara Y
Neurofibrillary tangles, dystrophic neurites (curly fibers), and abnormal phosphorylation of tau.
Brain pathology (Zurich, Switzerland) 1991;1(4):273-7.
1991: Ivy G O; Ihara Y; Kitani K
The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats.
Archives of gerontology and geriatrics 1991;12(2-3):119-31.
1991: Yamaguchi H; Nakazato Y; Shoji M; Okamoto K; Ihara Y; Morimatsu M; Hirai S
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.
The American journal of pathology 1991;138(3):699-705.
1991: Kanemaru K; Ihara Y
[Abnormal proteins in the brain in Alzheimer's disease]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1991;36(1):2-11.
1991: Hasegawa N; Ihara Y
[Biochemistry of alzheimer's disease]
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 1991;80(1):119-23.
1991: Yamaguchi H; Nakazato Y; Kawarabayashi T; Ishiguro K; Ihara Y; Morimatsu M; Hirai S
Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia.
Acta neuropathologica 1991;81(6):603-9.
1991: Tokuda T; Ikeda S; Yanagisawa N; Ihara Y; Glenner G G
Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid beta-protein and tau protein.
Acta neuropathologica 1991;82(4):280-5.
1990: Inui K; Namba R; Ihara Y; Nobukuni K; Taniike M; Midorikawa M; Tsukamoto H; Okada S
A case of chronic GM1 gangliosidosis presenting as dystonia: clinical and biochemical studies.
Journal of neurology 1990;237(8):491-3.
1990: Yamaguchi H; Ishiguro K; Shoji M; Yamazaki T; Nakazato Y; Ihara Y; Hirai S
Amyloid beta/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia.
Brain research 1990;537(1-2):318-22.
1990: Kanemaru K; Hasegawa M; Shimada H; Ihara Y
The presence of a novel protein in calf serum that recognizes beta amyloid in the formalin-fixed section.
The American journal of pathology 1990;137(3):677-87.
1990: Ihara Y; Kuroda S; Otsuki S
[A case of malignant thymoma associated with Eaton-Lambert-type neuromuscular transmission block and sensorimotor neuropathy]
Rinsho shinkeigaku = Clinical neurology 1990;30(7):750-3.
1990: Hasegawa M; Arai T; Ihara Y
Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease.
Neuron 1990;4(6):909-18.
1990: Murayama S; Mori H; Ihara Y; Tomonaga M
Immunocytochemical and ultrastructural studies of Pick's disease.
Annals of neurology 1990;27(4):394-405.
1990: Murayama S; Mori H; Ihara Y; Bouldin T W; Suzuki K; Tomonaga M
Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis.
Annals of neurology 1990;27(2):137-48.
1990: Yamaguchi H; Nakazato Y; Shoji M; Ihara Y; Hirai S
Ultrastructure of the neuropil threads in the Alzheimer brain: their dendritic origin and accumulation in the senile plaques.
Acta neuropathologica 1990;80(4):368-74.
1990: Ihara Y; Kondo J; Miura R; Nakagawa Y; Mori H; Honda T
Characterization of antisera to paired helical filaments and tau. Implication for the extent of tau tightly bound to paired helical filaments.
Gerontology 1990;36 Suppl 1():15-24.
1989: Ivy G O; Kitani K; Ihara Y
Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis?
Brain research 1989;498(2):360-5.
1989: Mann D M; Prinja D; Davies C A; Ihara Y; Delacourte A; Défossez A; Mayer R J; Landon M
Immunocytochemical profile of neurofibrillary tangles in Down's syndrome patients of different ages.
Journal of the neurological sciences 1989;92(2-3):247-60.
1989: Ihara Y
What mediates between beta-amyloid and paired helical filaments?
Neurobiology of aging 1989;10(5):573-4; discussion 588-90.
1989: Kanai Y; Takemura R; Oshima T; Mori H; Ihara Y; Yanagisawa M; Masaki T; Hirokawa N
Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA.
The Journal of cell biology 1989;109(3):1173-84.
1989: Ihara Y; Namba R; Kuroda S; Sato T; Shirabe T
Mitochondrial encephalomyopathy (MELAS): pathological study and successful therapy with coenzyme Q10 and idebenone.
Journal of the neurological sciences 1989;90(3):263-71.
1989: Kuzuhara S; Ihara Y; Toyokura Y; Shimada H
[A semiquantitative study on Alzheimer neurofibrillary tangles demonstrated immunohistochemically with anti-tau antibodies, in the brains of non-demented and demented old people]
No to shinkei = Brain and nerve 1989;41(5):465-70.
1989: Takio K; Hasegawa M; Titani K; Ihara Y
Identification of beta protein precursor in newborn rat brain.
Biochemical and biophysical research communications 1989;160(3):1296-301.
1989: Mori H; Hamada Y; Kawaguchi M; Honda T; Kondo J; Ihara Y
A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments.
Biochemical and biophysical research communications 1989;159(3):1221-6.
1989: Ihara Y; Kondo J
Polypeptide composition of paired helical filaments.
Annals of medicine 1989;21(2):121-5.
1989: Murayama S; Ookawa Y; Mori H; Nakano I; Ihara Y; Kuzuhara S; Tomonaga M
Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis.
Acta neuropathologica 1989;78(2):143-52.
1988: Tamaoka A; Ihara Y
[Immunocytochemical studies suggest the presence of non beta protein components in cerebrovascular and senile plaque core amyloid]
Rinsho shinkeigaku = Clinical neurology 1988;28(11):1312-7.
1988: Kondo J; Honda T; Mori H; Hamada Y; Miura R; Ogawara M; Ihara Y
The carboxyl third of tau is tightly bound to paired helical filaments.
Neuron 1988;1(9):827-34.
1988: Ishiguro K; Ihara Y; Uchida T; Imahori K
A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau.
Journal of biochemistry 1988;104(3):319-21.
1988: Ihara Y
Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease.
Brain research 1988;459(1):138-44.
1988: Ihara Y
[Alzheimer's disease. Biochemistry of paired helical filaments (PHF)]
Nippon Ronen Igakkai zasshi. Japanese journal of geriatrics 1988;25(4):364-7.
1988: Yamaguchi H; Hirai S; Momimatsu M; Ihara Y
[A comparative study on the ability to stain senile plaques with beta protein immunostain and three kinds of silver impregnation methods]
Rinsho shinkeigaku = Clinical neurology 1988;28(6):688-94.
1988: Uchida Y; Ihara Y; Tomonaga M
Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats.
Biochemical and biophysical research communications 1988;150(3):1263-7.
1988: Ihara Y; Namba R; Kuroda S
[A case of mitochondrial myopathy, encephalopathy, lactic acidosis and strokelike episodes (MELAS)--treatment with coenzyme Q10 and idebenone]
Rinsho shinkeigaku = Clinical neurology 1988;28(1):62-6.
1988: Kuzuhara S; Mori H; Izumiyama N; Yoshimura M; Ihara Y
Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study.
Acta neuropathologica 1988;75(4):345-53.
1988: Yamaguchi H; Hirai S; Morimatsu M; Shoji M; Ihara Y
A variety of cerebral amyloid deposits in the brains of the Alzheimer-type dementia demonstrated by beta protein immunostaining.
Acta neuropathologica 1988;76(6):541-9.
1987: Ihara Y; Namba R; Demiya M; Matsumoto T; Shirabe T
[A case of mitochondrial encephalomyopathy--Mitochondrial myopathy, encephalopathy, lactic acidosis and strokelike episodes (MELAS)]
Rinsho shinkeigaku = Clinical neurology 1987;27(8):969-75.
1987: Mori H; Kondo J; Ihara Y
Ubiquitin is a component of paired helical filaments in Alzheimer's disease.
Science (New York, N.Y.) 1987;235(4796):1641-4.
1986: Ihara Y
[Alzheimer's paired helical filaments]
Rinsho shinkeigaku = Clinical neurology 1986;26(12):1287-9.
1986: Ihara Y; Sato M; Otsuki S; Kaiya H; Namba M
Morphological changes in rat striatal boutons after chronic methamphetamine and haloperidol treatment.
Neuroscience research 1986;3(5):403-10.
1986: Ihara Y; Nukina N; Miura R; Ogawara M
Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.
Journal of biochemistry 1986;99(6):1807-10.
1986: Nukina N; Ihara Y
One of the antigenic determinants of paired helical filaments is related to tau protein.
Journal of biochemistry 1986;99(5):1541-4.
1986: Mukai M; Torikata C; Iri H; Morikawa Y; Shimizu K; Shimoda T; Nukina N; Ihara Y; Kageyama K
Expression of neurofilament triplet proteins in human neural tumors. An immunohistochemical study of paraganglioma, ganglioneuroma, ganglioneuroblastoma, and neuroblastoma.
The American journal of pathology 1986;122(1):28-35.
1985: Nukina N; Ihara Y
Proteolytic fragments of Alzheimer's paired helical filaments.
Journal of biochemistry 1985;98(6):1715-8.
1985: Ihara Y
[Alzheimer paired helical filament]
Seikagaku. The Journal of Japanese Biochemical Society 1985;57(10):1390-6.
1985: Nakase H; Inoue S; Ihara Y; Toyokura Y
[A case of perineuritis]
Rinsho shinkeigaku = Clinical neurology 1985;25(7):788-95.
1985: Murayama S; Nukina N; Ihara Y; Nakazato Y; Ishida Y; Takanashi R
[Immunocytochemistry of Pick's argentophilic bodies: evidence for the involvement of high molecular weight microtubule-associated proteins (HMWP) before the appearance of tubulin]
Rinsho shinkeigaku = Clinical neurology 1985;25(1):80-7.
1983: Kurisaki H; Ihara Y; Nukina N; Toyokura Y
[Immunocytochemical study of spheroid filament protein in amyotrophic lateral sclerosis using an antiserum to 200K peptide of neurofilament and anti-tubulin antibody]
Rinsho shinkeigaku = Clinical neurology 1983;23(11):1013-20.
1983: Ihara Y; Abraham C; Selkoe D J
Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins.
Nature 1983;304(5928):727-30.
1982: Selkoe D J; Abraham C; Ihara Y
Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers.
Proceedings of the National Academy of Sciences of the United States of America 1982;79(19):6070-4.
1982: Selkoe D J; Ihara Y; Salazar F J
Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea.
Science (New York, N.Y.) 1982;215(4537):1243-5.
1980: Nakanishi T; Tomonaga M; Ihara Y; Sakuta M; Tohgi H
Dissociated nystagmus in a comatose patient. A clinicopathological study.
Journal of neurology 1980;223(4):303-8.
1979: Ihara Y; Fujii T; Arai T; Tanaka R; Kaziro Y
The presence of an adenosine-5'-triphosphatase dependent on 6S tubulin and calcium ions in rat brain microtubules.
Journal of biochemistry 1979;86(2):587-90.
1975: Arai T; Ihara Y; Arai K; Kaziro Y
Purification of tubulin from bovine brain and its interaction with guanine nucleotides.
Journal of biochemistry 1975;77(3):647-58.

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