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James Ihle

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
22
Parganas, Evan
21
witthuhn, bruce
15
Wang, Denan
13
Cleveland, John
11
Thierfelder, William
11
Moriggl, Richard
11
Piekorz, Roland
10
Askew, David
9
Feng, Jian
9
Marine, Jean-Christophe
9
McKay, Catriona
8
Hoffmeyer, Angelika
8
Teglund, S
7
van Deursen, Jan
7
Miura, Osamu

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Publications

TOP 3
Funakoshi-Tago Megumi; Tago Kenji; Kasahara Tadashi; Parganas Evan; Ihle James N
Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.
Takahashi Yutaka; Takahashi Michiko; Carpino Nick; Jou Shiann-Tarng; Chao Jyh-Rong; Tanaka Satoshi; Shigeyoshi Yasufumi; Parganas Evan; Ihle James N
Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway.
Chao Jyh-Rong; Parganas Evan; Boyd Kelli; Hong Cheol Yi; Opferman Joseph T; Ihle James N
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.

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All Publications

2008: Funakoshi-Tago Megumi; Tago Kenji; Kasahara Tadashi; Parganas Evan; Ihle James N
Negative regulation of Jak2 by its auto-phosphorylation at tyrosine 913 via the Epo signaling pathway.
Cellular signalling 2008;20(11):1995-2001.
2008: Takahashi Yutaka; Takahashi Michiko; Carpino Nick; Jou Shiann-Tarng; Chao Jyh-Rong; Tanaka Satoshi; Shigeyoshi Yasufumi; Parganas Evan; Ihle James N
Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway.
Molecular endocrinology (Baltimore, Md.) 2008;22(7):1673-81.
2008: Chao Jyh-Rong; Parganas Evan; Boyd Kelli; Hong Cheol Yi; Opferman Joseph T; Ihle James N
Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
Nature 2008;452(7183):98-102.
2008: Funakoshi-Tago Megumi; Pelletier Stéphane; Moritake Hiroshi; Parganas Evan; Ihle James N
Jak2 FERM domain interaction with the erythropoietin receptor regulates Jak2 kinase activity.
Molecular and cellular biology 2008;28(5):1792-801.
2007: Ihle James N; Gilliland D Gary
Jak2: normal function and role in hematopoietic disorders.
Current opinion in genetics & development 2007;17(1):8-14.
2007: Gingras Sébastien; Pelletier Stéphane; Boyd Kelli; Ihle James N
Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP).
PloS one 2007;2(8):e808.
2006: Pelletier Stéphane; Gingras Sébastien; Funakoshi-Tago Megumi; Howell Sherié; Ihle James N
Two domains of the erythropoietin receptor are sufficient for Jak2 binding/activation and function.
Molecular and cellular biology 2006;26(22):8527-38.
2006: Funakoshi-Tago Megumi; Pelletier Stephane; Matsuda Tadashi; Parganas Evan; Ihle James N
Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2.
The EMBO journal 2006;25(20):4763-72.
2006: Gatzka Martina; Piekorz Roland; Moriggl Richard; Rawlings Jason; Ihle James N
A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.
Cytokine 2006;34(3-4):143-54.
2006: Takahashi Yutaka; Dominici Massimo; Swift John; Nagy Cristie; Ihle James N
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.
The Journal of biological chemistry 2006;281(17):11444-5.
2006: Zhang Ji; Randall Mindy S; Loyd Melanie R; Li Weimin; Schweers Rachel L; Persons Derek A; Rehg Jerold E; Noguchi Constance T; Ihle James N; Ney Paul A
Role of erythropoietin receptor signaling in Friend virus-induced erythroblastosis and polycythemia.
Blood 2006;107(1):73-8.
2005: Bertolino Eric; Reddy Karen; Medina Kay L; Parganas Evan; Ihle James; Singh Harinder
Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5.
Nature immunology 2005;6(8):836-43.
2005: Mead Paul E; Parganas Evan; Ohtsuka Shiro; Morishita Kazuhiro; Gamer Laura; Kuliyev Emin; Wright Christopher V E; Ihle James N
Evi-1 expression in Xenopus.
Gene expression patterns : GEP 2005;5(5):601-8.
2005: Piekorz Roland P; Gingras Sébastien; Hoffmeyer Angelika; Ihle James N; Weinstein Yacob
Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.
Molecular endocrinology (Baltimore, Md.) 2005;19(2):431-40.
2005: Moriggl Richard; Sexl Veronika; Kenner Lukas; Duntsch Christopher; Stangl Katharina; Gingras Sebastien; Hoffmeyer Angelika; Bauer Anton; Piekorz Roland; Wang Demin; Bunting Kevin D; Wagner Erwin F; Sonneck Karoline; Valent Peter; Ihle James N; Beug Hartmut
Stat5 tetramer formation is associated with leukemogenesis.
Cancer cell 2005;7(1):87-99.
2004: Matsuda Tadashi; Feng Jian; Witthuhn Bruce A; Sekine Yuichi; Ihle James N
Determination of the transphosphorylation sites of Jak2 kinase.
Biochemical and biophysical research communications 2004;325(2):586-94.
2004: Gingras Sébastien; Parganas Evan; de Pauw Antoine; Ihle James N; Murray Peter J
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling.
The Journal of biological chemistry 2004;279(52):54702-7.
2004: Schuendeln Michael M; Piekorz Roland P; Wichmann Christian; Lee Youngsoo; McKinnon Peter J; Boyd Kelli; Takahashi Yutaka; Ihle James N
The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer.
Molecular and cellular biology 2004;24(14):6403-9.
2004: Carpino Nick; Thierfelder William E; Chang Ming-shi; Saris Chris; Turner Steven J; Ziegler Steven F; Ihle James N
Absence of an essential role for thymic stromal lymphopoietin receptor in murine B-cell development.
Molecular and cellular biology 2004;24(6):2584-92.
2004: Carpino Nick; Turner Steve; Mekala Divya; Takahashi Yutaka; Zang Heesuk; Geiger Terrence L; Doherty Peter; Ihle James N
Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2.
Immunity 2004;20(1):37-46.
2003: Jeffers John R; Parganas Evan; Lee Youngsoo; Yang Chunying; Wang JinLing; Brennan Jennifer; MacLean Kirsteen H; Han Jiawen; Chittenden Thomas; Ihle James N; McKinnon Peter J; Cleveland John L; Zambetti Gerard P
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.
Cancer cell 2003;4(4):321-8.
2003: Lang Roland; Pauleau Anne-Laure; Parganas Evan; Takahashi Yutaka; Mages Jörg; Ihle James N; Rutschman Robert; Murray Peter J
SOCS3 regulates the plasticity of gp130 signaling.
Nature immunology 2003;4(6):546-50.
2003: Sexl Veronika; Kovacic Boris; Piekorz Roland; Moriggl Richard; Stoiber Dagmar; Hoffmeyer Angelika; Liebminger Rita; Kudlacek Oliver; Weisz Eva; Rothammer Kristen; Ihle James N
Jak1 deficiency leads to enhanced Abelson-induced B-cell tumor formation.
Blood 2003;101(12):4937-43.
2003: Takahashi Yutaka; Carpino Nick; Cross James C; Torres Miguel; Parganas Evan; Ihle James N
SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation.
The EMBO journal 2003;22(3):372-84.
2002: Jou Shiann-Tarng; Carpino Nick; Takahashi Yutaka; Piekorz Roland; Chao Jyh-Rong; Carpino Neena; Wang Demin; Ihle James N
Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.
Molecular and cellular biology 2002;22(24):8580-91.
2002: Carpino Nick; Kobayashi Ryuji; Zang Heesuk; Takahashi Yutaka; Jou Shiann-Tarrng; Feng Jian; Nakajima Hideaki; Ihle James N
Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein.
Molecular and cellular biology 2002;22(21):7491-500.
2002: Baudino Troy A; McKay Catriona; Pendeville-Samain Helene; Nilsson Jonas A; Maclean Kirsteen H; White Elsie L; Davis Ann C; Ihle James N; Cleveland John L
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression.
Genes & development 2002;16(19):2530-43.
2002: Zhao Shengming; Zoller Karen; Masuko Masayoshi; Rojnuckarin Ponlapat; Yang Xuexian O; Parganas Evan; Kaushansky Kenneth; Ihle James N; Papayannopoulou Thalia; Willerford Dennis M; Clackson Tim; Blau C Anthony
JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells.
The EMBO journal 2002;21(9):2159-67.
2002: Piekorz Roland P; Hoffmeyer Angelika; Duntsch Christopher D; McKay Catriona; Nakajima Hideaki; Sexl Veronika; Snyder Linda; Rehg Jerold; Ihle James N
The centrosomal protein TACC3 is essential for hematopoietic stem cell function and genetically interfaces with p53-regulated apoptosis.
The EMBO journal 2002;21(4):653-64.
2002: Bunting Kevin D; Bradley Heath L; Hawley Teresa S; Moriggl Richard; Sorrentino Brian P; Ihle James N
Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5.
Blood 2002;99(2):479-87.
2001: Nakajima H; Brindle P K; Handa M; Ihle J N
Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription.
The EMBO journal 2001;20(23):6836-44.
2001: Otto K G; Broudy V C; Lin N L; Parganas E; Luthi J N; Drachman J G; Ihle J N; Blau C A
Membrane localization is not required for Mpl function in normal hematopoietic cells.
Blood 2001;98(7):2077-83.
2001: Wang D; Boylin E C; Minegishi Y; Wen R; Smith C I; Ihle J N; Conley M E
Variations in the human phospholipase Cgamma2 gene in patients with B-cell defects of unknown etiology.
Immunogenetics 2001;53(7):550-6.
2001: Nakajima H; Ihle J N
Granulocyte colony-stimulating factor regulates myeloid differentiation through CCAAT/enhancer-binding protein epsilon.
Blood 2001;98(4):897-905.
2001: Ihle J
Pathways in cytokine regulation of hematopoiesis.
Annals of the New York Academy of Sciences 2001;938():129-30.
2001: Zang H; Sato K; Nakajima H; McKay C; Ney P A; Ihle J N
The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis.
The EMBO journal 2001;20(12):3156-66.
2001: Hoffmeyer A; Piekorz R; Moriggl R; Ihle J N
Gadd45gamma is dispensable for normal mouse development and T-cell proliferation.
Molecular and cellular biology 2001;21(9):3137-43.
2001: Rutschman R; Lang R; Hesse M; Ihle J N; Wynn T A; Murray P J
Cutting edge: Stat6-dependent substrate depletion regulates nitric oxide production.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2173-7.
2001: Wen R; Wang D; McKay C; Bunting K D; Marine J C; Vanin E F; Zambetti G P; Korsmeyer S J; Ihle J N; Cleveland J L
Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.
Molecular and cellular biology 2001;21(2):678-89.
2000: Diehl S; Anguita J; Hoffmeyer A; Zapton T; Ihle J N; Fikrig E; Rincón M
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1.
Immunity 2000;13(6):805-15.
2000: Schwaller J; Parganas E; Wang D; Cain D; Aster J C; Williams I R; Lee C K; Gerthner R; Kitamura T; Frantsve J; Anastasiadou E; Loh M L; Levy D E; Ihle J N; Gilliland D G
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2.
Molecular cell 2000;6(3):693-704.
2000: Sexl V; Piekorz R; Moriggl R; Rohrer J; Brown M P; Bunting K D; Rothammer K; Roussel M F; Ihle J N
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5.
Blood 2000;96(6):2277-83.
2000: Ihle J N
The challenges of translating knockout phenotypes into gene function.
Cell 2000;102(2):131-4.
2000: Wang D; Feng J; Wen R; Marine J C; Sangster M Y; Parganas E; Hoffmeyer A; Jackson C W; Cleveland J L; Murray P J; Ihle J N
Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors.
Immunity 2000;13(1):25-35.
2000: Wang D; Moriggl R; Stravopodis D; Carpino N; Marine J C; Teglund S; Feng J; Ihle J N
A small amphipathic alpha-helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5.
The EMBO journal 2000;19(3):392-9.
2000: Kieslinger M; Woldman I; Moriggl R; Hofmann J; Marine J C; Ihle J N; Beug H; Decker T
Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation.
Genes & development 2000;14(2):232-44.
1999: Marine J C; McKay C; Wang D; Topham D J; Parganas E; Nakajima H; Pendeville H; Yasukawa H; Sasaki A; Yoshimura A; Ihle J N
SOCS3 is essential in the regulation of fetal liver erythropoiesis.
Cell 1999;98(5):617-27.
1999: Marine J C; Topham D J; McKay C; Wang D; Parganas E; Stravopodis D; Yoshimura A; Ihle J N
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality.
Cell 1999;98(5):609-16.
1999: Brown M P; Nosaka T; Tripp R A; Brooks J; van Deursen J M; Brenner M K; Doherty P C; Ihle J N
Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3.
Blood 1999;94(6):1906-14.
1999: Moriggl R; Sexl V; Piekorz R; Topham D; Ihle J N
Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells.
Immunity 1999;11(2):225-30.
1999: Moriggl R; Topham D J; Teglund S; Sexl V; McKay C; Wang D; Hoffmeyer A; van Deursen J; Sangster M Y; Bunting K D; Grosveld G C; Ihle J N
Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells.
Immunity 1999;10(2):249-59.
1999: Moriggl R; Marine J C; Topham D J; Teglund S; Sexl V; McKay C; Piekorz R; Wang D; Parganas E; Yoshimura A; Ihle J N
Differential roles of cytokine signaling during T-cell development.
Cold Spring Harbor symposia on quantitative biology 1999;64():389-95.
1998: Ihle J N; Thierfelder W; Teglund S; Stravopodis D; Wang D; Feng J; Parganas E
Signaling by the cytokine receptor superfamily.
Annals of the New York Academy of Sciences 1998;865():1-9.
1998: Heydeck D; Thomas L; Schnurr K; Trebus F; Thierfelder W E; Ihle J N; Kühn H
Interleukin-4 and -13 induce upregulation of the murine macrophage 12/15-lipoxygenase activity: evidence for the involvement of transcription factor STAT6.
Blood 1998;92(7):2503-10.
1998: Packham G; White E L; Eischen C M; Yang H; Parganas E; Ihle J N; Grillot D A; Zambetti G P; Nuñez G; Cleveland J L
Selective regulation of Bcl-XL by a Jak kinase-dependent pathway is bypassed in murine hematopoietic malignancies.
Genes & development 1998;12(16):2475-87.
1998: Teglund S; McKay C; Schuetz E; van Deursen J M; Stravopodis D; Wang D; Brown M; Bodner S; Grosveld G; Ihle J N
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.
Cell 1998;93(5):841-50.
1998: Ihle J N; Stravapodis D; Parganas E; Thierfelder W; Feng J; Wang D; Teglund S
The roles of Jaks and Stats in cytokine signaling.
The cancer journal from Scientific American 1998;4 Suppl 1():S84-91.
1998: Parganas E; Wang D; Stravopodis D; Topham D J; Marine J C; Teglund S; Vanin E F; Bodner S; Colamonici O R; van Deursen J M; Grosveld G; Ihle J N
Jak2 is essential for signaling through a variety of cytokine receptors.
Cell 1998;93(3):385-95.
1998: Quelle F W; Wang J; Feng J; Wang D; Cleveland J L; Ihle J N; Zambetti G P
Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways.
Genes & development 1998;12(8):1099-107.
1998: Sohn S J; Forbush K A; Nguyen N; Witthuhn B; Nosaka T; Ihle J N; Perlmutter R M
Requirement for Jak3 in mature T cells: its role in regulation of T cell homeostasis.
Journal of immunology (Baltimore, Md. : 1950) 1998;160(5):2130-8.
1998: Bunting K D; Sangster M Y; Ihle J N; Sorrentino B P
Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer.
Nature medicine 1998;4(1):58-64.
1997: Shimoda K; Feng J; Murakami H; Nagata S; Watling D; Rogers N C; Stark G R; Kerr I M; Ihle J N
Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor.
Blood 1997;90(2):597-604.
1997: Vella A; Teague T K; Ihle J; Kappler J; Marrack P
Interleukin 4 (IL-4) or IL-7 prevents the death of resting T cells: stat6 is probably not required for the effect of IL-4.
The Journal of experimental medicine 1997;186(2):325-30.
1997: Feng J; Witthuhn B A; Matsuda T; Kohlhuber F; Kerr I M; Ihle J N
Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.
Molecular and cellular biology 1997;17(5):2497-501.
1997: Kohlhuber F; Rogers N C; Watling D; Feng J; Guschin D; Briscoe J; Witthuhn B A; Kotenko S V; Pestka S; Stark G R; Ihle J N; Kerr I M
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.
Molecular and cellular biology 1997;17(2):695-706.
1997: Ihle J N; Nosaka T; Thierfelder W; Quelle F W; Shimoda K
Jaks and Stats in cytokine signaling.
Stem cells (Dayton, Ohio) 1997;15 Suppl 1():105-11; discussion 112.
1996: Wang D; Stravopodis D; Teglund S; Kitazawa J; Ihle J N
Naturally occurring dominant negative variants of Stat5.
Molecular and cellular biology 1996;16(11):6141-8.
1996: Thierfelder W E; van Deursen J M; Yamamoto K; Tripp R A; Sarawar S R; Carson R T; Sangster M Y; Vignali D A; Doherty P C; Grosveld G C; Ihle J N
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells.
Nature 1996;382(6587):171-4.
1996: Quelle F W; Wang D; Nosaka T; Thierfelder W E; Stravopodis D; Weinstein Y; Ihle J N
Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.
Molecular and cellular biology 1996;16(4):1622-31.
1996: Shimoda K; van Deursen J; Sangster M Y; Sarawar S R; Carson R T; Tripp R A; Chu C; Quelle F W; Nosaka T; Vignali D A; Doherty P C; Grosveld G; Paul W E; Ihle J N
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene.
Nature 1996;380(6575):630-3.
1996: Ihle J N
Janus kinases in cytokine signalling.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 1996;351(1336):159-66.
1996: Briscoe J; Rogers N C; Witthuhn B A; Watling D; Harpur A G; Wilks A F; Stark G R; Ihle J N; Kerr I M
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
The EMBO journal 1996;15(4):799-809.
1996: Ihle J N
Signaling by the cytokine receptor superfamily in normal and transformed hematopoietic cells.
Advances in cancer research 1996;68():23-65.
1995: Nosaka T; van Deursen J M; Tripp R A; Thierfelder W E; Witthuhn B A; McMickle A P; Doherty P C; Grosveld G C; Ihle J N
Defective lymphoid development in mice lacking Jak3.
Science (New York, N.Y.) 1995;270(5237):800-2.
1995: Bellefroid E J; Marine J C; Matera A G; Bourguignon C; Desai T; Healy K C; Bray-Ward P; Martial J A; Ihle J N; Ward D C
Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(23):10757-61.
1995: Ihle J N
Cytokine receptor signalling.
Nature 1995;377(6550):591-4.
1995: Quelle F W; Thierfelder W; Witthuhn B A; Tang B; Cohen S; Ihle J N
Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor.
The Journal of biological chemistry 1995;270(35):20775-80.
1995: Kawahara A; Minami Y; Miyazaki T; Ihle J N; Taniguchi T
Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(19):8724-8.
1995: Ihle J N
The Janus protein tyrosine kinases in hematopoietic cytokine signaling.
Seminars in immunology 1995;7(4):247-54.
1995: Matsugi T; Kreider B L; Delwel R; Cleveland J L; Askew D S; Ihle J N
The Evi-1 zinc finger myeloid transforming protein binds to genomic fragments containing (GATA)n sequences.
Oncogene 1995;11(1):191-8.
1995: Fujii H; Nakagawa Y; Schindler U; Kawahara A; Mori H; Gouilleux F; Groner B; Ihle J N; Minami Y; Miyazaki T
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5482-6.
1995: Cleveland J L; Ihle J N
Contenders in FasL/TNF death signaling.
Cell 1995;81(4):479-82.
1995: Ihle J N; Kerr I M
Jaks and Stats in signaling by the cytokine receptor superfamily.
Trends in genetics : TIG 1995;11(2):69-74.
1995: Ihle J N
The Janus protein tyrosine kinase family and its role in cytokine signaling.
Advances in immunology 1995;60():1-35.
1995: Ihle J N; Witthuhn B A; Quelle F W; Yamamoto K; Silvennoinen O
Signaling through the hematopoietic cytokine receptors.
Annual review of immunology 1995;13():369-98.
1994: Beadling C; Guschin D; Witthuhn B A; Ziemiecki A; Ihle J N; Kerr I M; Cantrell D A
Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.
The EMBO journal 1994;13(23):5605-15.
1994: Tang B; Mano H; Yi T; Ihle J N
Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding.
Molecular and cellular biology 1994;14(12):8432-7.
1994: Miyazaki T; Kawahara A; Fujii H; Nakagawa Y; Minami Y; Liu Z J; Oishi I; Silvennoinen O; Witthuhn B A; Ihle J N
Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
Science (New York, N.Y.) 1994;266(5187):1045-7.
1994: Cleveland J L; Troppmair J; Packham G; Askew D S; Lloyd P; González-Garcia M; Nuñez G; Ihle J N; Rapp U R
v-raf suppresses apoptosis and promotes growth of interleukin-3-dependent myeloid cells.
Oncogene 1994;9(8):2217-26.
1994: Witthuhn B A; Silvennoinen O; Miura O; Lai K S; Cwik C; Liu E T; Ihle J N
Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells.
Nature 1994;370(6485):153-7.
1994: Yamamoto K; Quelle F W; Thierfelder W E; Kreider B L; Gilbert D J; Jenkins N A; Copeland N G; Silvennoinen O; Ihle J N
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
Molecular and cellular biology 1994;14(7):4342-9.
1994: Quelle F W; Sato N; Witthuhn B A; Inhorn R C; Eder M; Miyajima A; Griffin J D; Ihle J N
JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.
Molecular and cellular biology 1994;14(7):4335-41.
1994: Ihle J N
The Janus kinase family and signaling through members of the cytokine receptor superfamily.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):268-72.
1994: Carter-Su C; Argetsinger L S; Campbell G S; Wang X; Ihle J; Witthuhn B
The identification of JAK2 tyrosine kinase as a signaling molecule for growth hormone.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1994;206(3):210-5.
1994: Funabiki T; Kreider B L; Ihle J N
The carboxyl domain of zinc fingers of the Evi-1 myeloid transforming gene binds a consensus sequence of GAAGATGAG.
Oncogene 1994;9(6):1575-81.
1994: Campbell G S; Argetsinger L S; Ihle J N; Kelly P A; Rillema J A; Carter-Su C
Activation of JAK2 tyrosine kinase by prolactin receptors in Nb2 cells and mouse mammary gland explants.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(12):5232-6.
1994: Ihle J N; Witthuhn B A; Quelle F W; Yamamoto K; Thierfelder W E; Kreider B; Silvennoinen O
Signaling by the cytokine receptor superfamily: JAKs and STATs.
Trends in biochemical sciences 1994;19(5):222-7.
1994: Narazaki M; Witthuhn B A; Yoshida K; Silvennoinen O; Yasukawa K; Ihle J N; Kishimoto T; Taga T
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2285-9.
1994: Askew D S; Li J; Ihle J N
Retroviral insertions in the murine His-1 locus activate the expression of a novel RNA that lacks an extensive open reading frame.
Molecular and cellular biology 1994;14(3):1743-51.
1994: Ihle J N; Witthuhn B; Tang B; Yi T; Quelle F W
Cytokine receptors and signal transduction.
Baillière's clinical haematology 1994;7(1):17-48.
1994: Ihle J N; Witthuhn B A; Quelle F W; Silvennoinen O; Tang B; Yi T
Protein tyrosine phosphorylation in the regulation of hematopoiesis by receptors of the cytokine-receptor superfamily.
Blood cells 1994;20(1):65-80; discussion 80-2.
1993: Yi T; Mui A L; Krystal G; Ihle J N
Hematopoietic cell phosphatase associates with the interleukin-3 (IL-3) receptor beta chain and down-regulates IL-3-induced tyrosine phosphorylation and mitogenesis.
Molecular and cellular biology 1993;13(12):7577-86.
1993: Watling D; Guschin D; Müller M; Silvennoinen O; Witthuhn B A; Quelle F W; Rogers N C; Schindler C; Stark G R; Ihle J N
Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.
Nature 1993;366(6451):166-70.
1993: Askew D S; Ihle J N; Cleveland J L
Activation of apoptosis associated with enforced myc expression in myeloid progenitor cells is dominant to the suppression of apoptosis by interleukin-3 or erythropoietin.
Blood 1993;82(7):2079-87.
1993: Ihle J N; Quelle F W; Miura O
Signal transduction through the receptor for erythropoietin.
Seminars in immunology 1993;5(5):375-89.
1993: Miura O; Ihle J N
Dimer- and oligomerization of the erythropoietin receptor by disulfide bond formation and significance of the region near the WSXWS motif in intracellular transport.
Archives of biochemistry and biophysics 1993;306(1):200-8.
1993: Silvennoinen O; Witthuhn B A; Quelle F W; Cleveland J L; Yi T; Ihle J N
Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(18):8429-33.
1993: Argetsinger L S; Campbell G S; Yang X; Witthuhn B A; Silvennoinen O; Ihle J N; Carter-Su C
Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase.
Cell 1993;74(2):237-44.
1993: Witthuhn B A; Quelle F W; Silvennoinen O; Yi T; Tang B; Miura O; Ihle J N
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin.
Cell 1993;74(2):227-36.
1993: Kreider B L; Orkin S H; Ihle J N
Loss of erythropoietin responsiveness in erythroid progenitors due to expression of the Evi-1 myeloid-transforming gene.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(14):6454-8.
1993: Delwel R; Funabiki T; Kreider B L; Morishita K; Ihle J N
Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA.
Molecular and cellular biology 1993;13(7):4291-300.
1993: Yi T; Ihle J N
Association of hematopoietic cell phosphatase with c-Kit after stimulation with c-Kit ligand.
Molecular and cellular biology 1993;13(6):3350-8.
1993: Miura O; Ihle J N
Subunit structure of the erythropoietin receptor analyzed by 125I-Epo cross-linking in cells expressing wild-type or mutant receptors.
Blood 1993;81(7):1739-44.
1993: Miura O; Cleveland J L; Ihle J N
Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.
Molecular and cellular biology 1993;13(3):1788-95.
1993: Mano H; Mano K; Tang B; Koehler M; Yi T; Gilbert D J; Jenkins N A; Copeland N G; Ihle J N
Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit.
Oncogene 1993;8(2):417-24.
1993: Askew D S; Bartholomew C; Ihle J N
Insertional mutagenesis and the transformation of hematopoietic stem cells.
Hematologic pathology 1993;7(1):1-22.
1992: Yi T; Gilbert D J; Jenkins N A; Copeland N G; Ihle J N
Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6.
Genomics 1992;14(3):793-5.
1992: Morishita K; Parganas E; William C L; Whittaker M H; Drabkin H; Oval J; Taetle R; Valentine M B; Ihle J N
Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(9):3937-41.
1992: Yi T L; Cleveland J L; Ihle J N
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
Molecular and cellular biology 1992;12(2):836-46.
1992: Morishita K; Parganas E; Matsugi T; Ihle J N
Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor.
Molecular and cellular biology 1992;12(1):183-9.
1992: Ihle J N
Interleukin-3 and hematopoiesis.
Chemical immunology 1992;51():65-106.
1991: Yi T; Cleveland J L; Ihle J N
Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification.
Blood 1991;78(9):2222-8.
1991: Askew D S; Bartholomew C; Buchberg A M; Valentine M B; Jenkins N A; Copeland N G; Ihle J N
His-1 and His-2: identification and chromosomal mapping of two commonly rearranged sites of viral integration in a myeloid leukemia.
Oncogene 1991;6(11):2041-7.
1991: Miura O; D'Andrea A; Kabat D; Ihle J N
Induction of tyrosine phosphorylation by the erythropoietin receptor correlates with mitogenesis.
Molecular and cellular biology 1991;11(10):4895-902.
1991: Yi T L; Bolen J B; Ihle J N
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.
Molecular and cellular biology 1991;11(5):2391-8.
1991: Bartholomew C; Ihle J N
Retroviral insertions 90 kilobases proximal to the Evi-1 myeloid transforming gene activate transcription from the normal promoter.
Molecular and cellular biology 1991;11(4):1820-8.
1990: Morishita K; Parganas E; Parham D M; Matsugi T; Ihle J N
The Evi-1 zinc finger myeloid transforming gene is normally expressed in the kidney and in developing oocytes.
Oncogene 1990;5(9):1419-23.
1990: Morishita K; Parganas E; Douglass E C; Ihle J N
Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.
Oncogene 1990;5(7):963-71.
1990: Matsugi T; Morishita K; Ihle J N
Identification, nuclear localization, and DNA-binding activity of the zinc finger protein encoded by the Evi-1 myeloid transforming gene.
Molecular and cellular biology 1990;10(3):1259-64.
1990: Ihle J N; Morishita K; Bartholomew C; Matsugi T; Askew D
Phenotypes and mechanisms in the transformation of hematopoietic cells.
International journal of cell cloning 1990;8 Suppl 1():130-46.
1990: Ihle J N; Morishita K; Matsugi T; Bartholomew C
Insertional mutagenesis and transformation of hematopoietic stem cells.
Progress in clinical and biological research 1990;352():329-37.
1990: Morishita K; Parganas E; Bartholomew C; Sacchi N; Valentine M B; Raimondi S C; Le Beau M M; Ihle J N
The human Evi-1 gene is located on chromosome 3q24-q28 but is not rearranged in three cases of acute nonlymphocytic leukemias containing t(3;5)(q25;q34) translocations.
Oncogene research 1990;5(3):221-31.
1990: Isfort R J; Ihle J N
Multiple hematopoietic growth factors signal through tyrosine phosphorylation.
Growth factors (Chur, Switzerland) 1990;2(2-3):213-20.
1989: Bartholomew C; Morishita K; Askew D; Buchberg A; Jenkins N A; Copeland N G; Ihle J N
Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene.
Oncogene 1989;4(5):529-34.
1989: Ihle J N; Askew D
Origins and properties of hematopoietic growth factor-dependent cell lines.
International journal of cell cloning 1989;7(2):68-91.
1989: Ihle J N
The molecular and cellular biology of interleukin-3.
The Year in immunology 1989;5():59-102.
1989: Ihle J N; Morishita K; Parker D S; Bartholomew C; Askew D; Buchberg A; Jenkins N A; Copeland N; Weinstein Y
Mechanisms in the transformation of IL3-dependent hematopoietic stem cells.
Current topics in microbiology and immunology 1989;149():59-69.

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