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Johan Auwerx

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Ines Taes; Mieke Timmers; Philip Van Damme; Ludo Van Den Bosch; Johan Auwerx; André Bento-Abreu; Nicole Hersmus; Wim Robberecht
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.
Lo Lai; Misun Park; David A Sinclair; Stephen F Vatner; Lin Yan; Johan Auwerx; Claudio Bravo; Amy Davidow; Shumin Gao; Hui Ge; Che-Lin Hu; Yoshihiro Ishikawa; Kousaku Iwatsubo; Dorothy E Vatner
Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway.
Adrienne Mottis; Laurent Mouchiroud; Johan Auwerx
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.

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2013: Ines Taes; Mieke Timmers; Philip Van Damme; Ludo Van Den Bosch; Johan Auwerx; André Bento-Abreu; Nicole Hersmus; Wim Robberecht
Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS.
Human molecular genetics 2013;22(9):1783-90.
2013: Lo Lai; Misun Park; David A Sinclair; Stephen F Vatner; Lin Yan; Johan Auwerx; Claudio Bravo; Amy Davidow; Shumin Gao; Hui Ge; Che-Lin Hu; Yoshihiro Ishikawa; Kousaku Iwatsubo; Dorothy E Vatner
Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway.
Circulation 2013;127(16):1692-701.
2013: Adrienne Mottis; Laurent Mouchiroud; Johan Auwerx
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.
Genes & development 2013;27(8):819-35.
2013: Noura El-Jamal; Laurent Dubuquoy; Johan Auwerx; Benjamin Bertin; Pierre Desreumaux
In vivo imaging reveals selective PPAR activity in the skin of peroxisome proliferator-activated receptor responsive element-luciferase reporter mice.
Experimental dermatology 2013;22(2):137-40.
2013: Jérôme Fortin; Vikas Kumar; Kristina Schoonjans; Ying Wang; Xiang Zhou; Johan Auwerx; Ulrich Boehm; Derek Boerboom; Daniel J Bernard
NR5A2 regulates Lhb and Fshb transcription in gonadotrope-like cells in vitro, but is dispensable for gonadotropin synthesis and fertility in vivo.
PloS one 2013;8(3):e59058.
2013: Jennifer Murray; Johan Auwerx; Janice M Huss
Impaired myogenesis in estrogen-related receptor γ (ERRγ)-deficient skeletal myocytes due to oxidative stress.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013;27(1):135-50.
2012: Eija Pirinen; Giuseppe Lo Sasso; Johan Auwerx
Mitochondrial sirtuins and metabolic homeostasis.
Best practice & research. Clinical endocrinology & metabolism 2012;26(6):759-70.
2012: Joaquín Pérez-Schindler; Silvia Salatino; Serge Summermmatter; Erik van Nimwegen; Francesco Zorzato; Johan Auwerx; Piotr J Balwierz; Markus Beer; Jerome N Feige; Christoph Handschin
The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism.
Molecular and cellular biology 2012;32(24):4913-24.
2012: Lin Yan; Chujun Yuan; Chunbo Wang; Johan Auwerx; Mariana S De Lorenzo; Jean-Guillaume Dillinger; David Ho; Lo Lai; Ji Yeon Park; William C Stanley; Bin Tian; Dorothy E Vatner; Stephen F Vatner
Common mechanisms for calorie restriction and adenylyl cyclase type 5 knockout models of longevity.
Aging cell 2012;11(6):1110-20.
2012: Riekelt H Houtkooper; Johan Auwerx
Exploring the therapeutic space around NAD+.
The Journal of cell biology 2012;199(2):205-9.
2012: Pénélope A Andreux; Marie-France Champy; Hugues Henry; Riekelt H Houtkooper; Hana Koutnikova; Kristina Schoonjans; Evan G Williams; Robert W Williams; Johan Auwerx
Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits.
Cell 2012;150(6):1287-99.
2012: Valérie Hinard; Riekelt H Houtkooper; Cyril Mikhail; Sylvain Pradervand; Johan Auwerx; Thomas Curie; Paul Franken; Mehdi Tafti
Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(36):12506-17.
2012: Michalina Janiszewska; Paolo Provero; Ivan Radovanovic; Esther Rheinbay; Nicolò Riggi; Johan Auwerx; Virginie Clément-Schatlo; Riekelt H Houtkooper; Mario-Luca Suvà; Ivan Stamenkovic
Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.
Genes & development 2012;26(17):1926-44.
2012: Maaike H Oosterveer; Catherine Postic; Theo H van Dijk; Hiroyasu Yamamoto; Johan Auwerx; Eduard Ayuso; Fatima Bosch; Albert K Groen; Taoufiq Harach; Chikage Mataki; Norman Moullan; Kristina Schoonjans
LRH-1-dependent glucose sensing determines intermediary metabolism in liver.
The Journal of clinical investigation 2012;122(8):2817-26.
2012: Carles Cantó; Yana Cen; Philippe Cettour-Rose; Pablo J Fernandez-Marcos; Karl Gademann; Riekelt H Houtkooper; Maaike H Oosterveer; Eija Pirinen; Chris Rinsch; Anthony A Sauve; Kristina Schoonjans; Hiroyasu Yamamoto; Dou Y Youn; Pénélope A Andreux; Johan Auwerx
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity.
Cell metabolism 2012;15(6):838-47.
2012: Jamal Bouitbir; Anne-Laure Charles; Frédéric Daussin; Andoni Echaniz-Laguna; Bernard Geny; Michel Kindo; François Piquard; Johan Auwerx; Joffrey Zoll
Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1.
European heart journal 2012;33(11):1397-407.
2012: Carles Cantó; Johan Auwerx
Cell biology. FGF21 takes a fat bite.
Science (New York, N.Y.) 2012;336(6082):675-6.
2012: Han Cho; Ling-Wa Chong; Luciano DiTacchio; Michael Downes; Christopher K Glass; Megumi Hatori; Michael T Lam; Christopher Liddle; Satchidananda Panda; Ruth T Yu; Xuan Zhao; Annette R Atkins; Johan Auwerx; Grant D Barish; Ronald M Evans
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β.
Nature 2012;485(7396):123-7.
2012: Riekelt H Houtkooper; Eija Pirinen; Johan Auwerx
Sirtuins as regulators of metabolism and healthspan.
Nature reviews. Molecular cell biology 2012;13(4):225-38.
2012: Silvie Timmers; Johan Auwerx; Patrick Schrauwen
The journey of resveratrol from yeast to human.
Aging 2012;4(3):146-58.
2012: Mitsuhiro Watanabe; Eri Arita; Yasushi Horai; Sander M Houten; Hiroshi Itoh; Nao Kaneko-Iwasaki; Chikage Mataki; Kohkichi Morimoto; Karin Murahashi; Hiroyuki Sato; Kristina Schoonjans; Taichi Sugizaki; Tatsuya Suzuki; Johan Auwerx
Bile acid binding resin improves metabolic control through the induction of energy expenditure.
PloS one 2012;7(8):e38286.
2012: Autumn M McKnite; Maria Elisa Perez-Munoz; Daniel A Peterson; Xusheng Wang; Evan G Williams; Robert W Williams; Pénélope A Andreux; Johan Auwerx; John W M Bastiaansen; Andrew K Benson; Simon Brewer; Stephen D Kachman; Lu Lu; DC Ciobanu
Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.
PloS one 2012;7(6):e39191.
2012: Taoufiq Harach; Adriano Maida; Mitsunori Nomura; Thijs W H Pols; Johan Auwerx; Mitsuhiro Watanabe; Kristina Schoonjans
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.
Scientific reports 2012;2():430.
2012: Pablo J Fernandez-Marcos; Taoufiq Harach; Sander M Houten; Ellen H Jeninga; Norman Moullan; Eija Pirinen; Kristina Schoonjans; Hiroyasu Yamamoto; Penelope Andreux; Carles Canto; Vincent C J de Boer; Johan Auwerx
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.
Scientific reports 2012;2():425.
2011: Hiroyasu Yamamoto; Grant D Barish; Carles Cantó; Béatrice Desvergne; Michael Downes; Ronald M Evans; Weiwei Fan; Christophe Héligon; Laurent Mouchiroud; Kristina Schoonjans; Evan G Williams; Johan Auwerx
NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.
Cell 2011;147(4):827-39.
2011: Pingping Li; Min Lu; Sarah Nalbandian; Jachelle Ofrecio; DaYoung Oh; Johan Auwerx; Gautam K Bandyopadhyay; Ai Chen; Wuqiang Fan; Miriam Scadeng; Dorothy D Sears; Saswata Talukdar; Jianfeng Xu; Hiroyasu Yamamoto; Jerrold M Olefsky
Adipocyte NCoR knockout decreases PPARγ phosphorylation and enhances PPARγ activity and insulin sensitivity.
Cell 2011;147(4):815-26.
2011: Jintang Du; Quan Hao; Bin He; Hong Jiang; Saba Khan; Jungwoo Kim; Jun Huyn Kim; Johan Auwerx; Richard A Cerione; Wei Chen; Brian Hyun Choi; Xiaoyang Su; Jimin Woo; Jiu Jiu Yu; Sheng Zhang; Yeyun Zhou; Hening Lin
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Science (New York, N.Y.) 2011;334(6057):806-9.
2011: Silvie Timmers; Tineke van de Weijer; Sophie van der Krieken; Vera B Schrauwen-Hinderling; Johan Auwerx; Lena Bilet; Ellen E Blaak; Gijs H Goossens; Matthijs K C Hesselink; Joris Hoeks; Riekelt H Houtkooper; Sander Kersten; Ellen Konings; Iris Kunz; Esther Moonen-Kornips; Dongryeol Ryu; Patrick Schrauwen
Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.
Cell metabolism 2011;14(5):612-22.
2011: Bogdan Beirowski; Judith P Golden; Jason Gustin; Shaday Michan; Brian J North; Robert E Schmidt; David A Sinclair; Andreu Viader; Hiroyasu Yamamoto; Sean M Armour; Johan Auwerx; Robert H Baloh; Jeffrey Milbrandt
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):E952-61.
2011: Lilia G Noriega; Hiroyasu Yamamoto; Jiujiu Yu; Carles Canto; Jerome N Feige; Mark A Herman; Barbara B Kahn; Chikage Mataki; Johan Auwerx
CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.
EMBO reports 2011;12(10):1069-76.
2011: David Lombard; Scott D Pletcher; Carles Cantó; Johan Auwerx
Ageing: longevity hits a roadblock.
Nature 2011;477(7365):410-1.
2011: Emilie Blanchet; François Casas; Carine Chavey; Cyrielle Clapé; Victor Aguilar; Jean-Sébastien Annicotte; Florence Apparailly; Johan Auwerx; Vanessa Fritz; Sylviane Lagarrigue; Lluis Fajas
E2F transcription factor-1 regulates oxidative metabolism.
Nature cell biology 2011;13(9):1146-52.
2011: Carles Cantó; Johan Auwerx
Calorie restriction: is AMPK a key sensor and effector?
Physiology (Bethesda, Md.) 2011;26(4):214-24.
2011: Pablo J Fernandez-Marcos; Johan Auwerx; Kristina Schoonjans
Emerging actions of the nuclear receptor LRH-1 in the gut.
Biochimica et biophysica acta 2011;1812(8):947-55.
2011: Mitsuhiro Watanabe; Eri Arita; Yasushi Horai; Sander M Houten; Hiroshi Itoh; Chikage Mataki; Kohkichi Morimoto; Hiroyuki Sato; Kristina Schoonjans; Taichi Sugizaki; Yusuke Tanigawara; Johan Auwerx
Lowering bile acid pool size with a synthetic farnesoid X receptor (FXR) agonist induces obesity and diabetes through reduced energy expenditure.
The Journal of biological chemistry 2011;286(30):26913-20.
2011: Sandrine Dubrac; Andreas Elentner; Johan Auwerx; Kristina Schoonjans; Matthias Schmuth
Lack of IL-2 in PPAR-α-deficient mice triggers allergic contact dermatitis by affecting regulatory T cells.
European journal of immunology 2011;41(7):1980-91.
2011: Thijs W H Pols; Lilia G Noriega; Mitsunori Nomura; Johan Auwerx; Kristina Schoonjans
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.
Journal of hepatology 2011;54(6):1263-72.
2011: Carles Cantó; Johan Auwerx
Interference between PARPs and SIRT1: a novel approach to healthy ageing?
Aging 2011;3(5):543-7.
2011: Péter Bai; Carles Cantó; Hugues Oudart; Attila Brunyánszki; Yana Cen; Charles Thomas; Hiroyasu Yamamoto; Aline Huber; Borbála Kiss; Riekelt H Houtkooper; Kristina Schoonjans; Valérie Schreiber; Anthony A Sauve; Josiane Menissier-de Murcia; Johan Auwerx
PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.
Cell metabolism 2011;13(4):461-8.
2011: Péter Bai; Carles Canto; Attila Brunyánszki; Aline Huber; Magdolna Szántó; Yana Cen; Hiroyasu Yamamoto; Sander M Houten; Borbala Kiss; Hugues Oudart; Pál Gergely; Josiane Menissier-de Murcia; Valérie Schreiber; Anthony A Sauve; Johan Auwerx
PARP-2 regulates SIRT1 expression and whole-body energy expenditure.
Cell metabolism 2011;13(4):450-60.
2011: Pablo J Fernandez-Marcos; Johan Auwerx
Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis.
The American journal of clinical nutrition 2011;93(4):884S-90.
2011: Riekelt H Houtkooper; Ellen H Jeninga; Kristina Schoonjans; Charles Thomas; Pénélope A Andreux; Carmen Argmann; Carles Cantó; Raphaël Doenlen; Sander M Houten; Johan Auwerx
The metabolic footprint of aging in mice.
Scientific reports 2011;1():134.
2011: Thijs W H Pols; Johan Auwerx; Mitsunori Nomura; Lilia G Noriega; Kristina Schoonjans
The bile acid membrane receptor TGR5: a valuable metabolic target.
Digestive diseases (Basel, Switzerland) 2011;29(1):37-44.
2010: Cédric Genet; Céline Schmidt; Axelle Strehle; Kristina Schoonjans; Johan Auwerx; Régis Saladin; Alain Wagner
Redefining the TGR5 triterpenoid binding pocket at the C-3 position.
ChemMedChem 2010;5(12):1983-8.
2010: Raffaele Teperino; Kristina Schoonjans; Johan Auwerx
Histone methyl transferases and demethylases; can they link metabolism and transcription?
Cell metabolism 2010;12(4):321-7.
2010: Carles Cantó; Johan Auwerx
AMP-activated protein kinase and its downstream transcriptional pathways.
Cellular and molecular life sciences : CMLS 2010;67(20):3407-23.
2010: Pablo J Fernandez-Marcos; Johan Auwerx
pRb, a switch between bone and brown fat.
Developmental cell 2010;19(3):360-2.
2010: E H Jeninga; K Schoonjans; Johan Auwerx
Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility.
Oncogene 2010;29(33):4617-24.
2010: Riekelt H Houtkooper; Johan Auwerx
Obesity: New life for antidiabetic drugs.
Nature 2010;466(7305):443-4.
2010: Riekelt H Houtkooper; Robert Williams; Johan Auwerx
Metabolic networks of longevity.
Cell 2010;142(1):9-14.
2010: Jiujiu Yu; Johan Auwerx
Protein deacetylation by SIRT1: an emerging key post-translational modification in metabolic regulation.
Pharmacological research : the official journal of the Italian Pharmacological Society 2010;62(1):35-41.
2010: T W H Pols; Johan Auwerx; K Schoonjans
Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease.
Gastroentérologie clinique et biologique 2010;34(4-5):270-3.
2010: Jarno Rutanen; Nagendra Yaluri; Shalem Modi; Jussi Pihlajamäki; Markku Vänttinen; Paula Itkonen; Sakari Kainulainen; Hiroyasu Yamamoto; Marie Lagouge; David A Sinclair; Peter Elliott; Christoph Westphal; Johan Auwerx; Markku Laakso
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity.
Diabetes 2010;59(4):829-35.
2010: Riekelt H Houtkooper; Carles Cantó; Ronald J Wanders; Johan Auwerx
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.
Endocrine reviews 2010;31(2):194-223.
2010: Carles Cantó; Lake Q Jiang; Atul S Deshmukh; Chikage Mataki; Agnes Coste; Marie Lagouge; Juleen R Zierath; Johan Auwerx
Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle.
Cell metabolism 2010;11(3):213-9.
2010: Jerome N Feige; Alan Gerber; Cristina Casals-Casas; Qian Yang; Carine Winkler; Elodie Bedu; Manuel Bueno; Laurent Gelman; Johan Auwerx; FJ Gonzalez; Béatrice Desvergne
The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms.
Environmental health perspectives 2010;118(2):234-41.
2010: Salvatore Modica; Francoise Gofflot; Stefania Murzilli; Andria D'Orazio; Lorena Salvatore; Fabio Pellegrini; Antonio Nicolucci; Giovanni Tognoni; Massimiliano Copetti; Rosa Valanzano; Serena Veschi; Renato Mariani-Costantini; Giuseppe Palasciano; Kristina Schoonjans; Johan Auwerx; Antonio Moschetta
The intestinal nuclear receptor signature with epithelial localization patterns and expression modulation in tumors.
Gastroenterology 2010;138(2):636-48, 648.e1-12.
2010: Cédric Genet; Axelle Strehle; Céline Schmidt; Geoffrey Boudjelal; Annelise Lobstein; Kristina Schoonjans; Michel Souchet; Johan Auwerx; Régis Saladin; Alain Wagner
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Journal of medicinal chemistry 2010;53(1):178-90.
2010: Lise Lefèvre; Amandine Galès; David Olagnier; José Bernad; Laurence Perez; Rémy Burcelin; Alexis Valentin; Johan Auwerx; Bernard Pipy; Agnès Coste
PPARγ ligands switched high fat diet-induced macrophage M2b polarization toward M2a thereby improving intestinal Candida elimination.
PloS one 2010;5(9):e12828.
2010: Carles Cantó; Johan Auwerx
Clking on PGC-1alpha to inhibit gluconeogenesis.
Cell metabolism 2010;11(1):6-7.
2010: Amandine Galès; Annabelle Conduché; José Bernad; Lise Lefevre; David Olagnier; Maryse Béraud; Guillaume Martin-Blondel; Marie Denise Linas; Johan Auwerx; Agnès Coste; Bernard Pipy
PPARgamma controls dectin-1 expression required for host antifungal defense against Candida albicans.
PLoS pathogens 2010;6(1):e1000714.
2009: Roberto Pellicciari; Antimo Gioiello; Antonio Macchiarulo; Charles Thomas; Emiliano Rosatelli; Benedetto Natalini; Roccaldo Sardella; Mark Pruzanski; Aldo Roda; Elisabetta Pastorini; Kristina Schoonjans; Johan Auwerx
Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.
Journal of medicinal chemistry 2009;52(24):7958-61.
2009: Carmen Argmann; Radu Dobrin; Sami Heikkinen; Aurélie Auburtin; Laurent Pouilly; Terrie-Anne Cock; Hana Koutnikova; Jun Zhu; Eric E Schadt; Johan Auwerx
Ppargamma2 is a key driver of longevity in the mouse.
PLoS genetics 2009;5(12):e1000752.
2009: David H Volle; Mélanie Decourteix; Erwan Garo; Judy McNeilly; Patrick Fenichel; Johan Auwerx; Alan S McNeilly; Kristina Schoonjans; Mohamed Benahmed
The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice.
The Journal of clinical investigation 2009;119(12):3752-64.
2009: Jiujiu Yu; Johan Auwerx
The role of sirtuins in the control of metabolic homeostasis.
Annals of the New York Academy of Sciences 2009;1173 Suppl 1():E10-9.
2009: Charles Thomas; Antimo Gioiello; Lilia Noriega; Axelle Strehle; Julien Oury; Giovanni Rizzo; Antonio Macchiarulo; Hiroyasu Yamamoto; Chikage Mataki; Mark Pruzanski; Roberto Pellicciari; Johan Auwerx; Kristina Schoonjans
TGR5-mediated bile acid sensing controls glucose homeostasis.
Cell metabolism 2009;10(3):167-77.
2009: Carles Cantó; Johan Auwerx
Caloric restriction, SIRT1 and longevity.
Trends in endocrinology and metabolism: TEM 2009;20(7):325-31.
2009: Mary-Elizabeth Patti; Sander M Houten; Antonio Bianco; Raquel Bernier; P Reed Larsen; Jens J Holst; Michael K Badman; Eleftheria Maratos-Flier; Edward C Mun; Jussi Pihlajamaki; Johan Auwerx; Allison B Goldfine
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.
Obesity (Silver Spring, Md.) 2009;17(9):1671-7.
2009: Hana Koutnikova; Markku Laakso; Lu Lu; Roy Combe; Jussi Paananen; Teemu Kuulasmaa; Johanna Kuusisto; Hans-Ulrich Häring; Torben Hansen; Oluf Pedersen; Ulf Smith; Markolf Hanefeld; Robert Williams; Johan Auwerx
Identification of the UBP1 locus as a critical blood pressure determinant using a combination of mouse and human genetics.
PLoS genetics 2009;5(8):e1000591.
2009: Nadine Cybulski; Pazit Polak; Johan Auwerx; Markus A Rüegg; Michael N Hall
mTOR complex 2 in adipose tissue negatively controls whole-body growth.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(24):9902-7.
2009: Carles Cantó; Zachary Gerhart-Hines; Jerome N Feige; Marie Lagouge; Lilia Noriega; Jill C Milne; Peter J Elliott; Pere Puigserver; Johan Auwerx
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Nature 2009;458(7241):1056-60.
2009: Carles Cantó; Johan Auwerx
PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure.
Current opinion in lipidology 2009;20(2):98-105.
2009: Sami Heikkinen; Carmen Argmann; Jerome N Feige; Hana Koutnikova; Marie-France Champy; Nassim Dali-Youcef; Eric E Schadt; Markku Laakso; Johan Auwerx
The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface.
Cell metabolism 2009;9(1):88-98.
2009: Jérome Terrand; Véronique Bruban; Li Zhou; Wanfeng Gong; Zeina El Asmar; Petra May; Kai Zurhove; Philipp Haffner; Claude Philippe; Estelle Woldt; Rachel L Matz; Céline Gracia; Daniel Metzger; Johan Auwerx; Joachim Herz; Philippe Boucher
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.
The Journal of biological chemistry 2009;284(1):381-8.
2008: Agnès Coste; Jean-Francois Louet; Marie Lagouge; Carles Lerin; Maria Cristina Antal; H Meziane; Kristina Schoonjans; Pere Puigserver; Bert W O'Malley; Johan Auwerx
The genetic ablation of SRC-3 protects against obesity and improves insulin sensitivity by reducing the acetylation of PGC-1{alpha}.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(44):17187-92.
2008: Pazit Polak; Nadine Cybulski; Jerome N Feige; Johan Auwerx; Markus A Rüegg; Michael N Hall
Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.
Cell metabolism 2008;8(5):399-410.
2008: Jerome N Feige; Marie Lagouge; Carles Canto; Axelle Strehle; Sander M Houten; Jill C Milne; Philip D Lambert; Chikage Mataki; Peter J Elliott; Johan Auwerx
Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation.
Cell metabolism 2008;8(5):347-58.
2008: Jerome N Feige; Marie Lagouge; Johan Auwerx
Dietary manipulation of mouse metabolism.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2008;Chapter 29():Unit 29B.5.
2008: Antonio Macchiarulo; Antimo Gioiello; Charles Thomas; Alberto Massarotti; Roberto Nuti; Emiliano Rosatelli; Paola Sabbatini; Kristina Schoonjans; Johan Auwerx; Roberto Pellicciari
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5.
Journal of chemical information and modeling 2008;48(9):1792-801.
2008: silvia mandillo; Valter Tucci; Sabine M Hölter; Hamid Meziane; Mumna Banchaabouchi; Magdalena Kallnik; Heena V Lad; Patrick M Nolan; Abdel-Mouttalib Ouagazzal; Emma L Coghill; Karin Gale; Elisabetta Golini; Sylvie Jacquot; Wojtek Krezel; Andy Parker; Fabrice Riet; Ilka Schneider; Daniela Marazziti; Johan Auwerx; Steve D M Brown; Pierre Chambon; Nadia Rosenthal; Glauco Tocchini-Valentini; Wolfgang Wurst
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.
Physiological genomics 2008;34(3):243-55.
2008: Charles Thomas; Roberto Pellicciari; Mark Pruzanski; Johan Auwerx; Kristina Schoonjans
Targeting bile-acid signalling for metabolic diseases.
Nature reviews. Drug discovery 2008;7(8):678-93.
2008: Rajesha Duggavathi; David H Volle; Chikage Mataki; Maria C Antal; Nadia Messaddeq; Johan Auwerx; Bruce D Murphy; Kristina Schoonjans
Liver receptor homolog 1 is essential for ovulation.
Genes & development 2008;22(14):1871-6.
2008: Carles Cantó; Johan Auwerx
Glucose restriction: longevity SIRTainly, but without building muscle?
Developmental cell 2008;14(5):642-4.
2008: Marie-France Champy; Mohammed Selloum; Valérie Zeitler; Claudia Caradec; Barbara Jung; Stéphane Rousseau; Laurent Pouilly; Tania Sorg; Johan Auwerx
Genetic background determines metabolic phenotypes in the mouse.
Mammalian genome : official journal of the International Mammalian Genome Society 2008;19(5):318-31.
2008: Agnès Coste; Céline Lagane; Cédric Filipe; Hélène Authier; Amandine Galès; José Bernad; Victorine Douin-Echinard; Jean-Claude Lepert; Patricia Balard; Marie Denise Linas; Jean-François Arnal; Johan Auwerx; Bernard Pipy
IL-13 attenuates gastrointestinal candidiasis in normal and immunodeficient RAG-2(-/-) mice via peroxisome proliferator-activated receptor-gamma activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(7):4939-47.
2008: Hiroyuki Sato; Antonio Macchiarulo; Charles Thomas; Antimo Gioiello; Mizuho Une; Alan Hofmann; Régis Saladin; Kristina Schoonjans; Roberto Pellicciari; Johan Auwerx
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
Journal of medicinal chemistry 2008;51(6):1831-41.
2008: Carine Delayre-Orthez; Julien Becker; Johan Auwerx; Nelly Frossard; Françoise Pons
Suppression of allergen-induced airway inflammation and immune response by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate.
European journal of pharmacology 2008;581(1-2):177-84.
2008: Charles Thomas; Johan Auwerx; Kristina Schoonjans
Bile acids and the membrane bile acid receptor TGR5--connecting nutrition and metabolism.
Thyroid : official journal of the American Thyroid Association 2008;18(2):167-74.
2007: Péter Bai; Sander M Houten; Aline Huber; Valérie Schreiber; Mitsuhiro Watanabe; Borbála Kiss; Gilbert de Murcia; Johan Auwerx; Josiane Ménissier-de Murcia
Poly(ADP-ribose) polymerase-2 [corrected] controls adipocyte differentiation and adipose tissue function through the regulation of the activity of the retinoid X receptor/peroxisome proliferator-activated receptor-gamma [corrected] heterodimer.
The Journal of biological chemistry 2007;282(52):37738-46.
2007: Chikage Mataki; Benjamin C Magnier; Sander M Houten; Jean-Sébastien Annicotte; Carmen Argmann; Charles Thomas; Henk Overmars; Wim Kulik; Daniel Metzger; Johan Auwerx; Kristina Schoonjans
Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1.
Molecular and cellular biology 2007;27(23):8330-9.
2007: Hiroyuki Sato; Cédric Genet; Axelle Strehle; Charles Thomas; Annelise Lobstein; Alain Wagner; Charles Mioskowski; Johan Auwerx; Régis Saladin
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea.
Biochemical and biophysical research communications 2007;362(4):793-8.
2007: Jerome N Feige; Johan Auwerx
DisSIRTing on LXR and cholesterol metabolism.
Cell metabolism 2007;6(5):343-5.
2007: Francoise Gofflot; Nathalie Chartoire; Laurent Vasseur; Sami Heikkinen; Doulaye Dembele; Julie LE MERRER; Johan Auwerx
Systematic gene expression mapping clusters nuclear receptors according to their function in the brain.
Cell 2007;131(2):405-18.
2007: Cristina Antal; Marius Teletin; Olivia Wendling; Mounzer Dgheem; Johan Auwerx; Manuel Mark
Tissue collection for systematic phenotyping in the mouse.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2007;Chapter 29():Unit 29A.4.
2007: Soumya Rasouri; Marie Lagouge; Johan Auwerx
[SIRT1/PGC-1: a neuroprotective axis?].
Médecine sciences : M/S 2007;23(10):840-4.
2007: Roberto Pellicciari; Hiroyuki Sato; Antimo Gioiello; Gabriele Costantino; Antonio Macchiarulo; Bahman M Sadeghpour; Gianluca Giorgi; Kristina Schoonjans; Johan Auwerx
Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5.
Journal of medicinal chemistry 2007;50(18):4265-8.
2007: Agnès Coste; Laurent Dubuquoy; Romain Barnouin; Jean-Sébastien Annicotte; Benjamin C Magnier; Mario Notti; Nadia Corazza; Maria Cristina Antal; Daniel Metzger; Pierre Desreumaux; Thomas Brunner; Johan Auwerx; Kristina Schoonjans
LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(32):13098-103.
2007: Sami Heikkinen; Johan Auwerx; Carmen A Argmann
PPARgamma in human and mouse physiology.
Biochimica et biophysica acta 2007;1771(8):999-1013.
2007: Hiroyasu Yamamoto; Kristina Schoonjans; Johan Auwerx
Sirtuin functions in health and disease.
Molecular endocrinology (Baltimore, Md.) 2007;21(8):1745-55.
2007: Nassim Dali-Youcef; Chikage Mataki; Agnès Coste; Nadia Messaddeq; Sylvain Giroud; Stéphane Blanc; Christian Koehl; Marie-France Champy; Pierre Chambon; Lluis Fajas; Daniel Metzger; Kristina Schoonjans; Johan Auwerx
Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(25):10703-8.
2007: Jerome N Feige; Johan Auwerx
Transcriptional coregulators in the control of energy homeostasis.
Trends in cell biology 2007;17(6):292-301.
2007: Antoine Berry; Patricia Balard; Agnès Coste; David Olagnier; Céline Lagane; Hélène Authier; Françoise Benoit-Vical; Jean-Claude Lepert; Jean-Paul Séguéla; Jean-François Magnaval; Pierre Chambon; Daniel Metzger; Béatrice Desvergne; Walter Wahli; Johan Auwerx; Bernard Pipy
IL-13 induces expression of CD36 in human monocytes through PPARgamma activation.
European journal of immunology 2007;37(6):1642-52.
2007: Sander M Houten; David H Volle; Carolyn L Cummins; David J Mangelsdorf; Johan Auwerx
In vivo imaging of farnesoid X receptor activity reveals the ileum as the primary bile acid signaling tissue.
Molecular endocrinology (Baltimore, Md.) 2007;21(6):1312-23.
2007: Manuel Mark; Marius Teletin; Cristina Antal; Olivia Wendling; Johan Auwerx; Sami Heikkinen; Konstantin Khetchoumian; Carmen A Argmann; Mounzer Dgheem
Histopathology in mouse metabolic investigations.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2007;Chapter 29():Unit 29B.4.
2007: Sandrine Dubrac; Patrizia Stoitzner; Daniela Pirkebner; Andreas Elentner; Kristina Schoonjans; Johan Auwerx; Sem Saeland; Paul Hengster; Peter Fritsch; Nikolaus Romani; Matthias Schmuth
Peroxisome proliferator-activated receptor-alpha activation inhibits Langerhans cell function.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(7):4362-72.
2007: David H Volle; Rajesha Duggavathi; Benjamin C Magnier; Sander M Houten; Carolyn L Cummins; Jean-Marc Lobaccaro; Guido Verhoeven; Kristina Schoonjans; Johan Auwerx
The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice.
Genes & development 2007;21(3):303-15.
2007: Sami Heikkinen; Carmen A Argmann; Marie-France Champy; Johan Auwerx
Evaluation of glucose homeostasis.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2007;Chapter 29():Unit 29B.3.
2007: Nassim Dali-Youcef; Marie Lagouge; Sébastien Froelich; Christian Koehl; Kristina Schoonjans; Johan Auwerx
Sirtuins: the 'magnificent seven', function, metabolism and longevity.
Annals of medicine 2007;39(5):335-45.
2007: Philippe Boucher; Wei-Ping Li; Rachel L Matz; Yoshiharu Takayama; Johan Auwerx; Richard G W Anderson; Joachim Herz
LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome.
PloS one 2007;2(5):e448.
2007: Niels Grarup; Mette K Andersen; Camilla H Andreasen; Anders Albrechtsen; Knut Borch-Johnsen; Torben Jørgensen; Johan Auwerx; Ole Schmitz; Torben Hansen; Oluf Pedersen
Studies of the common DIO2 Thr92Ala polymorphism and metabolic phenotypes in 7342 Danish white subjects.
The Journal of clinical endocrinology and metabolism 2007;92(1):363-6.
2006: Marie Lagouge; Carmen Argmann; Zachary Gerhart-Hines; Hamid Meziane; Carles Lerin; Frédéric Daussin; Nadia Messadeq; Jill Milne; Philip Lambert; Peter Elliott; Bernard Geny; Markku Laakso; Pere Puigserver; Johan Auwerx
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Cell 2006;127(6):1109-22.
2006: Liliane Michalik; Johan Auwerx; Joel P Berger; V Krishna Chatterjee; Christopher K Glass; Frank J Gonzalez; Paul A Grimaldi; Takashi Kadowaki; Mitchell Lazar; Stephen O'Rahilly; Colin N A Palmer; Jorge Plutzky; Janardan K Reddy; Bruce M Spiegelman; Bart Staels; Walter Wahli
International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.
Pharmacological reviews 2006;58(4):726-41.
2006: Jean-Francois Louet; Agnès Coste; Larbi Amazit; Mounia Tannour-Louet; Ray-Chang Wu; Sophia Y Tsai; Ming-Jer Tsai; Johan Auwerx; Bert W O'Malley
Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(47):17868-73.
2006: Carmen Argmann; Johan Auwerx
Insulin secretion: SIRT4 gets in on the act.
Cell 2006;126(5):837-9.
2006: Carmen A Argmann; Sander M Houten; Marie-France Champy; Johan Auwerx
Lipid and bile acid analysis.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 29():Unit 29B.2.
2006: Carmen A Argmann; Johan Auwerx
Collection of blood and plasma from the mouse.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 29():Unit 29A.3.
2006: Paula Peltola; Jussi Pihlajamäki; Hana Koutnikova; Eija Ruotsalainen; Urpu Salmenniemi; Ilkka Vauhkonen; Sakari Kainulainen; Helena Gylling; Tatu A Miettinen; Johan Auwerx; Markku Laakso
Visceral obesity is associated with high levels of serum squalene.
Obesity (Silver Spring, Md.) 2006;14(7):1155-63.
2006: Cécile Loichot; Laurence Jesel; Angela Tesse; Antonia Tabernero; Kristina Schoonjans; Gerald Roul; Irina Carpusca; Johan Auwerx; Ramaroson Andriantsitohaina
Deletion of peroxisome proliferator-activated receptor-alpha induces an alteration of cardiac functions.
American journal of physiology. Heart and circulatory physiology 2006;291(1):H161-6.
2006: Agnès Coste; Maria Cristina Antal; Susan Chan; Philippe Kastner; Manuel Mark; Bert W O'Malley; Johan Auwerx
Absence of the steroid receptor coactivator-3 induces B-cell lymphoma.
The EMBO journal 2006;25(11):2453-64.
2006: Sander M Houten; Mitsuhiro Watanabe; Johan Auwerx
Endocrine functions of bile acids.
The EMBO journal 2006;25(7):1419-25.
2006: Angelina Rodriguez; Angeles Durán; Mohammed Selloum; Marie-France Champy; Francisco J Diez-Guerra; Juana M Flores; Manuel Serrano; Johan Auwerx; María T Diaz-Meco; Jorge Moscat
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
Cell metabolism 2006;3(3):211-22.
2006: Carmen A Argmann; Marie-France Champy; Johan Auwerx
Evaluation of energy homeostasis.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 29():Unit 29B.1.
2006: Carmen A Argmann; Johan Auwerx
Minimizing variation due to genotype and environment.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 29():Unit 29A.2.
2006: Carmen A Argmann; Andree Dierich; Johan Auwerx
Uses of forward and reverse genetics in mice to study gene function.
Current protocols in molecular biology / edited by Frederick M. Ausubel ... [et al.] 2006;Chapter 29():Unit 29A.1.
2006: Mitsuhiro Watanabe; Sander M Houten; Chikage Mataki; Marcelo A Christoffolete; Brian W. Kim; Hiroyuki Sato; Nadia Messaddeq; John W Harney; Osamu Ezaki; Tatsuhiko Kodama; Kristina Schoonjans; Antonio Bianco; Johan Auwerx
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
Nature 2006;439(7075):484-9.
2006: Johan Auwerx
Improving metabolism by increasing energy expenditure.
Nature medicine 2006;12(1):44-5; discussion 45.
2005: Svetlana Morozova; Isabelle Suc-Royer; Johan Auwerx
[Cholesterol metabolism modulators in future drug therapy for atherosclerosis].
Médecine sciences : M/S 2005;21 Spec No():53-8.
2005: Carmen A Argmann; Pierre Chambon; Johan Auwerx
Mouse phenogenomics: the fast track to "systems metabolism".
Cell metabolism 2005;2(6):349-60.
2005: Marie-Bernard Debril; Laurent Dubuquoy; Jerome N Feige; Walter Wahli; Béatrice Desvergne; Johan Auwerx; Laurent Gelman
Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity.
Journal of molecular endocrinology 2005;35(3):503-17.
2005: Aline Meirhaeghe; Michael W T Tanck; Lluis Fajas; Caroline Janot; Nicole Helbecque; Dominique Cottel; Johan Auwerx; Philippe Amouyel; Jean Dallongeville
Study of a new PPARgamma2 promoter polymorphism and haplotype analysis in a French population.
Molecular genetics and metabolism 2005;85(2):140-8.
2005: Christel Rousseaux; Bruno Lefebvre; Laurent Dubuquoy; Philippe Lefebvre; Olivier Romano; Johan Auwerx; Daniel Metzger; Walter Wahli; Béatrice Desvergne; Gian Carlo Naccari; Philippe CHAVATTE; Amaury Farce; Philippe Bulois; Antoine Cortot; Jean-Frédéric Colombel; Pierre Desreumaux
Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma.
The Journal of experimental medicine 2005;201(8):1205-15.
2005: Kristina Schoonjans; Laurent Dubuquoy; Joseph Mebis; Elisabeth Fayard; Olivia Wendling; Céline Haby; Karel Geboes; Johan Auwerx
Liver receptor homolog 1 contributes to intestinal tumor formation through effects on cell cycle and inflammation.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(6):2058-62.
2005: Sébastien Dharancy; Mathilde Malapel; Gabriel Perlemuter; Tania Roskams; Yang Cheng; Laurent Dubuquoy; Philippe Podevin; Filomena Conti; Valérie Canva; David Philippe; Luc Gambiez; Philippe Mathurin; Jean-Claude Paris; Kristina Schoonjans; Yvon Calmus; Stanislas Pol; Johan Auwerx; Pierre Desreumaux
Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.
Gastroenterology 2005;128(2):334-42.
2005: Carmen A Argmann; Terrie-Anne Cock; Johan Auwerx
Peroxisome proliferator-activated receptor gamma: the more the merrier?
European journal of clinical investigation 2005;35(2):82-92; discussion 80.
2005: Carine Delayre-Orthez; Julien Becker; Isabelle Guenon; Vincent Lagente; Johan Auwerx; Nelly Frossard; Françoise Pons
PPARalpha downregulates airway inflammation induced by lipopolysaccharide in the mouse.
Respiratory research 2005;6():91.
2004: Chris Knouff; Johan Auwerx
Peroxisome proliferator-activated receptor-gamma calls for activation in moderation: lessons from genetics and pharmacology.
Endocrine reviews 2004;25(6):899-918.
2004: Marie-France Champy; Mohammed Selloum; Laetitia Piard; Valerie Zeitler; Claudia Caradec; Pierre Chambon; Johan Auwerx
Mouse functional genomics requires standardization of mouse handling and housing conditions.
Mammalian genome : official journal of the International Mammalian Genome Society 2004;15(10):768-83.
2004: Sander M Houten; Johan Auwerx
PGC-1alpha: turbocharging mitochondria.
Cell 2004;119(1):5-7.
2004: Terrie-Anne Cock; Jonathan Back; Florent Elefteriou; Gerard Karsenty; Philippe Kastner; Susan Chan; Johan Auwerx
Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen.
EMBO reports 2004;5(10):1007-12.
2004: Sung Hee Um; Francesca Frigerio; Mitsuhiro Watanabe; Frédéric Picard; Manel Joaquin; Melanie Sticker; Stefano Fumagalli; Peter R Allegrini; Sara C Kozma; Johan Auwerx; George Thomas
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.
Nature 2004;431(7005):200-5.
2004: Oronza A Botrugno; Elisabeth Fayard; Jean-Sébastien Annicotte; Céline Haby; Thomas Brennan; Olivia Wendling; Toshiya Tanaka; Tatsuhiko Kodama; Winston Thomas; Johan Auwerx; Kristina Schoonjans
Synergy between LRH-1 and beta-catenin induces G1 cyclin-mediated cell proliferation.
Molecular cell 2004;15(4):499-509.
2004: Svetlana Morozova; Isabelle Suc-Royer; Johan Auwerx
[Cholesterol metabolism modulators and the future of atherosclerosis therapy].
Médecine sciences : M/S 2004;20(6-7):685-90.
2004: Mitsuhiro Watanabe; Sander M Houten; Li Wang; Antonio Moschetta; David J Mangelsdorf; Richard A Heyman; David D Moore; Johan Auwerx
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
The Journal of clinical investigation 2004;113(10):1408-18.
2004: Elisabeth Fayard; Johan Auwerx; Kristina Schoonjans
LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.
Trends in cell biology 2004;14(5):250-60.
2004: Lluis Fajas; Jean-Sébastien Annicotte; Stéphanie Miard; David Sarruf; Mitsuhiro Watanabe; Johan Auwerx
Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice.
The Journal of clinical investigation 2004;113(9):1288-95.
2004: Knut Tomas Dalen; Kristina Schoonjans; Stine M Ulven; Mina Susanne Weedon-Fekjaer; Trine Gjesti Bentzen; Hana Koutnikova; Johan Auwerx; Hilde I Nebb
Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma.
Diabetes 2004;53(5):1243-52.
2004: Marie-Bernard Debril; Laurent Gelman; Elisabeth Fayard; Jean-Sébastien Annicotte; Stéphane Rocchi; Johan Auwerx
Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit.
The Journal of biological chemistry 2004;279(16):16677-86.
2004: Matthias Schmuth; Christopher Haqq; William J Cairns; Julie C Holder; Sheri Tinnell Dorsam; Sandra Chang; Peggy Lau; Ashley J Fowler; Gary Chuang; Arthur H Moser; Barbara E Brown; Man Mao-Qiang; Yoshikazu Uchida; Kristina Schoonjans; Johan Auwerx; P Chambon; Timothy M Willson; Peter M Elias; Kenneth R Feingold
Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes.
The Journal of investigative dermatology 2004;122(4):971-83.
2004: Jean-Sébastien Annicotte; Kristina Schoonjans; Johan Auwerx
Expression of the liver X receptor alpha and beta in embryonic and adult mice.
The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 2004;277(2):312-6.
2004: Bénédicte Mascrez; Norbert B Ghyselinck; Mitsuhiro Watanabe; Jean-Sébastien Annicotte; Pierre Chambon; Johan Auwerx; Manuel Mark
Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells.
EMBO reports 2004;5(3):285-90.
2004: Terrie-Anne Cock; Sander M Houten; Johan Auwerx
Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm.
EMBO reports 2004;5(2):142-7.
2004: Sander M Houten; Johan Auwerx
The enterohepatic nuclear receptors are major regulators of the enterohepatic circulation of bile salts.
Annals of medicine 2004;36(7):482-91.
2003: Toshiya Tanaka; Joji Yamamoto; Satoshi Iwasaki; Hiroshi Asaba; Hiroki Hamura; Yukio Ikeda; Mitsuhiro Watanabe; Kenta Magoori; Ryoichi X Ioka; Keisuke Tachibana; Yuichiro Watanabe; Yasutoshi Uchiyama; Koichi Sumi; Haruhisa Iguchi; Sadayoshi Ito; Takefumi Doi; Takao Hamakubo; Makoto Naito; Johan Auwerx; Masashi Yanagisawa; Tatsuhiko Kodama; Juro Sakai
Activation of peroxisome proliferator-activated receptor delta induces fatty acid beta-oxidation in skeletal muscle and attenuates metabolic syndrome.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15924-9.
2003: Johan Auwerx; Jacques Drouin; Vincent Laudet
Récepteurs à la Provençale. EMBO workshop on the biology of nuclear receptors.
EMBO reports 2003;4(12):1122-6.
2003: Hana Koutnikova; Terrie-Anne Cock; Mitsuhiro Watanabe; Sander M Houten; Marie-France Champy; Andrée Dierich; Johan Auwerx
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(24):14457-62.
2003: Terrie-Anne Cock; Johan Auwerx
Leptin: cutting the fat off the bone.
Lancet 2003;362(9395):1572-4.
2003: Cristina Banfi; Johan Auwerx; Federica Poma; Elena Tremoli; Luciana Mussoni
Induction of plasminogen activator inhibitor I by the PPARalpha ligand, Wy-14,643, is dependent on ERK1/2 signaling pathway.
Thrombosis and haemostasis 2003;90(4):611-9.
2003: Jean-Sébastien Annicotte; Elisabeth Fayard; Galvin Swift; Lars Selander; Ulla Edlund; Toshiya Tanaka; Tatsuhiko Kodama; Kristina Schoonjans; Johan Auwerx
Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.
Molecular and cellular biology 2003;23(19):6713-24.
2003: Elisabeth Fayard; Kristina Schoonjans; Jean-Sébastien Annicotte; Johan Auwerx
Liver receptor homolog 1 controls the expression of carboxyl ester lipase.
The Journal of biological chemistry 2003;278(37):35725-31.
2003: Lluis Fajas; Stéphanie Miard; Michael R Briggs; Johan Auwerx
Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase.
Journal of lipid research 2003;44(9):1652-9.
2003: Gaëtane Woerly; Kohei Honda; Marc Loyens; Jean-Paul Papin; Johan Auwerx; Bart Staels; Monique Capron; David Dombrowicz
Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation.
The Journal of experimental medicine 2003;198(3):411-21.
2003: Lluis Fajas; Viviane Egler; Raphael Reiter; Stéphanie Miard; Anne-Marie Lefebvre; Johan Auwerx
PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner.
Oncogene 2003;22(27):4186-93.
2003: Gordon A Francis; Jean-Sébastien Annicotte; Johan Auwerx
PPAR-alpha effects on the heart and other vascular tissues.
American journal of physiology. Heart and circulatory physiology 2003;285(1):H1-9.
2003: Laurent Dubuquoy; Eva Jansson; Samir Deeb; Sabine Rakotobe; Mehdi Karoui; Jean-Frédéric Colombel; Johan Auwerx; Sven Pettersson; Pierre Desreumaux
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis.
Gastroenterology 2003;124(5):1265-76.
2003: Gordon A Francis; Jean-Sébastien Annicotte; Johan Auwerx
PPAR agonists in the treatment of atherosclerosis.
Current opinion in pharmacology 2003;3(2):186-91.
2003: Aline Meirhaeghe; Lluis Fajas; Fabrice Gouilleux; Dominique Cottel; Nicole Helbecque; Johan Auwerx; Philippe Amouyel
A functional polymorphism in a STAT5B site of the human PPAR gamma 3 gene promoter affects height and lipid metabolism in a French population.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(2):289-94.
2003: Johan Auwerx; Terrie-Ann Cock; Chris Knouff
PPAR-gamma: a thrifty transcription factor.
Nuclear receptor signaling 2003;1():e006.
2003: Hana Koutnikova; Elisabeth Fayard; Jürgen Lehmann; Johan Auwerx
Serial analysis of gene expression and gene trapping to identify nuclear receptor target genes.
Methods in enzymology 2003;364():299-322.
2003: Gordon A Francis; Elisabeth Fayard; Frédéric Picard; Johan Auwerx
Nuclear receptors and the control of metabolism.
Annual review of physiology 2003;65():261-311.
2002: Frédéric Picard; Martine Géhin; Jean-Sébastien Annicotte; Stéphane Rocchi; Marie-France Champy; Bert W O'Malley; Pierre Chambon; Johan Auwerx
SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
Cell 2002;111(7):931-41.
2002: Matthias Schmuth; Kristina Schoonjans; Qian-Chun Yu; Joachim W Fluhr; Debra Crumrine; Jean-Pierre Hachem; Peggy Lau; Johan Auwerx; Peter M Elias; Kenneth R Feingold
Role of peroxisome proliferator-activated receptor alpha in epidermal development in utero.
The Journal of investigative dermatology 2002;119(6):1298-303.
2002: Lluis Fajas; Viviane Egler; Raphael Reiter; Jacob Hansen; Karsten Kristiansen; Marie-Bernard Debril; Stéphanie Miard; Johan Auwerx
The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation.
Developmental cell 2002;3(6):903-10.
2002: Kristina Schoonjans; Jean-Sébastien Annicotte; Thierry Huby; Oronza A Botrugno; Elisabeth Fayard; Yukihiko Ueda; John Chapman; Johan Auwerx
Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I.
EMBO reports 2002;3(12):1181-7.
2002: Frédéric Picard; Mitsuhiro Wanatabe; Kristina Schoonjans; John Lydon; Bert W O'Malley; Johan Auwerx
Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(24):15644-8.
2002: Laurent Dubuquoy; Sébastien Dharancy; Sophie Nutten; Sven Pettersson; Johan Auwerx; Pierre Desreumaux
Role of peroxisome proliferator-activated receptor gamma and retinoid X receptor heterodimer in hepatogastroenterological diseases.
Lancet 2002;360(9343):1410-8.
2002: Thierry Fournier; Laetitia Pavan; Anne Tarrade; Kristina Schoonjans; Johan Auwerx; Cécile Rochette-Egly; Danièle Evain-Brion
The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion.
Annals of the New York Academy of Sciences 2002;973():26-30.
2002: Gordon A Francis; Jean-Sébastien Annicotte; Johan Auwerx
Liver X receptors: Xcreting Xol to combat atherosclerosis.
Trends in molecular medicine 2002;8(10):455-8.
2002: Carole Brendel; Kristina Schoonjans; Oronza A Botrugno; Eckardt Treuter; Johan Auwerx
The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.
Molecular endocrinology (Baltimore, Md.) 2002;16(9):2065-76.
2002: Kristina Schoonjans; Johan Auwerx
A sharper image of SHP.
Nature medicine 2002;8(8):789-91.
2002: Sonia Eligini; Marta Brambilla; Cristina Banfi; Marina Camera; Luigi Sironi; Silvia Barbieri; Johan Auwerx; Elena Tremoli; Susanna Colli
Oxidized phospholipids inhibit cyclooxygenase-2 in human macrophages via nuclear factor-kappaB/IkappaB- and ERK2-dependent mechanisms.
Cardiovascular research 2002;55(2):406-15.
2002: Lluis Fajas; Rebecca L Landsberg; Yolande Huss-Garcia; Claude Sardet; Jacqueline A Lees; Johan Auwerx
E2Fs regulate adipocyte differentiation.
Developmental cell 2002;3(1):39-49.
2002: Hana Koutnikova; Johan Auwerx
PPARgamma, an X-ceptor for Xs.
Annals of the New York Academy of Sciences 2002;967():28-33.
2002: Carole Brendel; Laurent Gelman; Johan Auwerx
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
Molecular endocrinology (Baltimore, Md.) 2002;16(6):1367-77.
2002: Kati Ylitalo; Ilpo Nuotio; Jorma Viikari; Johan Auwerx; Hubert Vidal; Marja-Riitta Taskinen
C3, hormone-sensitive lipase, and peroxisome proliferator-activated receptor gamma expression in adipose tissue of familial combined hyperlipidemia patients.
Metabolism: clinical and experimental 2002;51(5):664-70.
2002: Antonia Tabernero; Kristina Schoonjans; Laurence Jesel; Irina Carpusca; Johan Auwerx; Ramaroson Andriantsitohaina
Activation of the peroxisome proliferator-activated receptor alpha protects against myocardial ischaemic injury and improves endothelial vasodilatation.
BMC pharmacology 2002;2():10.
2002: Johan Auwerx
Nuclear receptors. I. PPAR gamma in the gastrointestinal tract: gain or pain?
American journal of physiology. Gastrointestinal and liver physiology 2002;282(4):G581-5.
2002: Toshiya Tanaka; Tetsu Takeno; Yuichiro Watanabe; Yasutoshi Uchiyama; Takeshi Murakami; Hisahiko Yamashita; Akifumi Suzuki; Rie Aoi; Hiroko Iwanari; Shu-Ying Jiang; Makoto Naito; Keisuke Tachibana; Takefumi Doi; Andrew I Shulman; David J Mangelsdorf; Raphael Reiter; Johan Auwerx; Takao Hamakubo; Tatsuhiko Kodama
The generation of monoclonal antibodies against human peroxisome proliferator-activated receptors (PPARs).
Journal of atherosclerosis and thrombosis 2002;9(5):233-42.
2002: Frédéric Picard; Johan Auwerx
PPAR(gamma) and glucose homeostasis.
Annual review of nutrition 2002;22():167-97.
2002: MARY SHEU; Ashley J Fowler; Jack Kao; Matthias Schmuth; Kristina Schoonjans; Johan Auwerx; Joachim W Fluhr; Mao-Qiang Man; Peter M Elias; Kenneth R Feingold
Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models.
The Journal of investigative dermatology 2002;118(1):94-101.
2001: Hana Koutnikova; Johan Auwerx
Regulation of adipocyte differentiation.
Annals of medicine 2001;33(8):556-61.
2001: Jean-Sébastien Annicotte; Kristina Schoonjans; Céline Haby; Johan Auwerx
An E-box in pGL3 reporter vectors precludes their use for the study of sterol regulatory element-binding proteins.
BioTechniques 2001;31(5):993-4, 996.
2001: Taro E Akiyama; Christopher J Nicol; Catherine Fievet; Bart Staels; Jerrold M Ward; Johan Auwerx; S S Lee; Frank J Gonzalez; Jeffrey M Peters
Peroxisome proliferator-activated receptor-alpha regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines.
The Journal of biological chemistry 2001;276(42):39088-93.
2001: Stéphane Rocchi; Frédéric Picard; Joseph Vamecq; Laurent Gelman; Noelle Potier; D Zeyer; Laurent Dubuquoy; Pierre Bac; Marie-France Champy; Kelli D Plunket; Lisa M Leesnitzer; Steven G Blanchard; Pierre Desreumaux; Dino Moras; Jean-Paul Renaud; Johan Auwerx
A unique PPARgamma ligand with potent insulin-sensitizing yet weak adipogenic activity.
Molecular cell 2001;8(4):737-47.
2001: Anne Tarrade; Kristina Schoonjans; Laetitia Pavan; Johan Auwerx; Cécile Rochette-Egly; Danièle Evain-Brion; Thierry Fournier
PPARgamma/RXRalpha heterodimers control human trophoblast invasion.
The Journal of clinical endocrinology and metabolism 2001;86(10):5017-24.
2001: Anne Tarrade; Kristina Schoonjans; Jean Guibourdenche; Jean-Michel Bidart; Michel Vidaud; Johan Auwerx; Cécile Rochette-Egly; Danièle Evain-Brion
PPAR gamma/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation.
Endocrinology 2001;142(10):4504-14.
2001: Lluis Fajas; Marie-Bernard Debril; Johan Auwerx
Peroxisome proliferator-activated receptor-gamma: from adipogenesis to carcinogenesis.
Journal of molecular endocrinology 2001;27(1):1-9.
2001: Jennifer Rieusset; Cécile Chambrier; Karim Bouzakri; Eric Dusserre; Johan Auwerx; Jean-Paul Riou; Martine Laville; Hubert Vidal
The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes.
Diabetologia 2001;44(5):544-54.
2001: Pierre Desreumaux; Laurent Dubuquoy; Sophie Nutten; M Peuchmaur; W Englaro; Kristina Schoonjans; B Derijard; Béatrice Desvergne; Walter Wahli; P Chambon; M D Leibowitz; Jean-Frédéric Colombel; Johan Auwerx
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.
The Journal of experimental medicine 2001;193(7):827-38.
2001: Elisabeth Fayard; Kristina Schoonjans; Johan Auwerx
Xol INXS: role of the liver X and the farnesol X receptors.
Current opinion in lipidology 2001;12(2):113-20.
2001: T Claudel; Mark D Leibowitz; Catherine Fiévet; Anne Tailleux; B Wagner; Joyce J Repa; Gérard Torpier; Jean-Marc Lobaccaro; James R Paterniti; D J Mangelsdorf; Richard A Heyman; Johan Auwerx
Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2610-5.
2001: Lluis Fajas; Marie-Bernard Debril; Johan Auwerx
PPAR gamma: an essential role in metabolic control.
Nutrition, metabolism, and cardiovascular diseases : NMCD 2001;11(1):64-9.
2001: Peter Davies; S A Berry; Gregory L Shipley; R H Eckel; Nathalie Hennuyer; Diane L Crombie; Kathleen M Ogilvie; Julia Peinado-Onsurbe; Catherine Fievet; Mark D Leibowitz; Richard A Heyman; Johan Auwerx
Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity.
Molecular pharmacology 2001;59(2):170-6.
2001: Marie-Bernard Debril; Jean-Paul Renaud; Lluis Fajas; Johan Auwerx
The pleiotropic functions of peroxisome proliferator-activated receptor gamma.
Journal of molecular medicine (Berlin, Germany) 2001;79(1):30-47.
2000: Kristina Schoonjans; Carole Brendel; D Mangelsdorf; Johan Auwerx
Sterols and gene expression: control of affluence.
Biochimica et biophysica acta 2000;1529(1-3):114-25.
2000: Stéphane Rocchi; Johan Auwerx
Peroxisome proliferator-activated receptor gamma, the ultimate liaison between fat and transcription.
The British journal of nutrition 2000;84 Suppl 2():S223-7.
2000: Kristina Schoonjans; Laurent Gelman; Céline Haby; M Briggs; Johan Auwerx
Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes.
Journal of molecular biology 2000;304(3):323-34.
2000: Christophe BINNERT; Hannu Koistinen; G Martin; Fabrizio Andreelli; Pertti Ebeling; Veikko Koivisto; Martine Laville; Johan Auwerx; Hubert Vidal
Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans.
American journal of physiology. Endocrinology and metabolism 2000;279(5):E1072-9.
2000: László G Kömüves; Karen Hanley; Anne-Marie Lefebvre; Mao-Qiang Man; Dean C Ng; Daniel David Bikle; Mary L Williams; Peter M Elias; Johan Auwerx; Kenneth R Feingold
Stimulation of PPARalpha promotes epidermal keratinocyte differentiation in vivo.
The Journal of investigative dermatology 2000;115(3):353-60.
2000: Laurent Dubuquoy; C Bourdon; M Peuchmaur; M D Leibowitz; Sophie Nutten; Jean-Frédéric Colombel; Johan Auwerx; Pierre Desreumaux
[Peroxisome proliferator-activated receptor (PPAR) gamma: a new target for the treatment of inflammatory bowel disease].
Gastroentérologie clinique et biologique 2000;24(8-9):719-24.
2000: Jussi Pihlajamäki; Raija Miettinen; RH Valve; L Karjalainen; Leena Mykkänen; Johanna Kuusisto; Samir S Deeb; Johan Auwerx; Markku Laakso
The Pro12A1a substitution in the peroxisome proliferator activated receptor gamma 2 is associated with an insulin-sensitive phenotype in families with familial combined hyperlipidemia and in nondiabetic elderly subjects with dyslipidemia.
Atherosclerosis 2000;151(2):567-74.
2000: G Martin; M Nemoto; Laurent Gelman; S Geffroy; J Najib; Jean-Charles Fruchart; P Roevens; B de Martinville; Samir S Deeb; Johan Auwerx
The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression.
Genomics 2000;66(3):296-304.
2000: Mark D Leibowitz; Catherine Fiévet; Nathalie Hennuyer; Julia Peinado-Onsurbe; Hélène Duez; J Bergera; C A Cullinan; Carl P Sparrow; Joanne Baffic; G D Berger; C Santini; R W Marquis; Richard L Tolman; Roy G Smith; David E Moller; Johan Auwerx
Activation of PPARdelta alters lipid metabolism in db/db mice.
FEBS letters 2000;473(3):333-6.
2000: Kari Anne Risan Tobin; Hilde Hermansen Steineger; S Alberti; OS Spydevold; Johan Auwerx; Jan-�ke GUSTAFSSON; Hilde I Nebb
Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.
Molecular endocrinology (Baltimore, Md.) 2000;14(5):741-52.
2000: Aline Meirhaeghe; G Martin; M Nemoto; Samir S Deeb; Dominique Cottel; Johan Auwerx; Philippe Amouyel; Nicole Helbecque
Intronic polymorphism in the fatty acid transport protein 1 gene is associated with increased plasma triglyceride levels in a French population.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(5):1330-4.
2000: G Martin; Hélène Poirier; Nathalie Hennuyer; Diane L Crombie; Jean-Charles Fruchart; Richard A Heyman; Philippe Besnard; Johan Auwerx
Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective rexinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target.
The Journal of biological chemistry 2000;275(17):12612-8.
2000: Karen Hanley; László G Kömüves; Dean C Ng; Kristina Schoonjans; SS He; Peggy Lau; Daniel David Bikle; Mary L Williams; Peter M Elias; Johan Auwerx; Kenneth R Feingold
Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha.
The Journal of biological chemistry 2000;275(15):11484-91.
2000: Kristina Schoonjans; Johan Auwerx
Thiazolidinediones: an update.
Lancet 2000;355(9208):1008-10.
1999: Jennifer Rieusset; Johan Auwerx; Hubert Vidal
Regulation of gene expression by activation of the peroxisome proliferator-activated receptor gamma with rosiglitazone (BRL 49653) in human adipocytes.
Biochemical and biophysical research communications 1999;265(1):265-71.
1999: RH Valve; Katariina Sivenius; Raija Miettinen; Jussi Pihlajamäki; Aila Rissanen; Samir S Deeb; Johan Auwerx; Matti Uusitupa; Markku Laakso
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women.
The Journal of clinical endocrinology and metabolism 1999;84(10):3708-12.
1999: M Lefebvre; Bernhard Paulweber; Lluis Fajas; J Woods; C McCrary; J F Colombel; J Najib; Jean-Charles Fruchart; Christian Datz; Hubert Vidal; P Desreumaux; Johan Auwerx
Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells.
The Journal of endocrinology 1999;162(3):331-40.
1999: Lluis Fajas; Kristina Schoonjans; Laurent Gelman; J B Kim; J Najib; G Martin; Jean-Charles Fruchart; M Briggs; Bruce M Spiegelman; Johan Auwerx
Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism.
Molecular and cellular biology 1999;19(8):5495-503.
1999: Pierre Desreumaux; Olivier Ernst; K Geboes; Luc Gambiez; D Berrebi; H Müller-Alouf; Samira Hafraoui; D Emilie; N Ectors; M Peuchmaur; Antoine Cortot; M Capron; Johan Auwerx; Jean-Frédéric Colombel
Inflammatory alterations in mesenteric adipose tissue in Crohn's disease.
Gastroenterology 1999;117(1):73-81.
1999: K Schoonjans; Julia Peinado-Onsurbe; Jean-Charles Fruchart; Anne Tailleux; Catherine Fiévet; Johan Auwerx
3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase.
FEBS letters 1999;452(3):160-4.
1999: Jennifer Rieusset; Fabrizio Andreelli; D Auboeuf; Marina Roques; Paulette Vallier; Jean-Paul Riou; Johan Auwerx; Martine Laville; Hubert Vidal
Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes.
Diabetes 1999;48(4):699-705.
1999: Laurent Gelman; G Zhou; Lluis Fajas; Eric Raspé; Jean-Charles Fruchart; Johan Auwerx
p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.
The Journal of biological chemistry 1999;274(12):7681-8.
1999: R Saladin; Lluis Fajas; S Dana; Y D Halvorsen; Johan Auwerx; M Briggs
Differential regulation of peroxisome proliferator activated receptor gamma1 (PPARgamma1) and PPARgamma2 messenger RNA expression in the early stages of adipogenesis.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1999;10(1):43-8.
1998: Anne-Marie Lefebvre; I Chen; P Desreumaux; J Najib; Jean-Charles Fruchart; K Geboes; M Briggs; R Heyman; Johan Auwerx
Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice.
Nature medicine 1998;4(9):1053-7.
1998: Mercedes Ricote; J Huang; Lluis Fajas; A Li; J Welch; J Najib; Joseph L Witztum; Johan Auwerx; W Palinski; Christopher K Glass
Expression of the peroxisome proliferator-activated receptor gamma (PPARgamma) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(13):7614-9.
1998: G Martin; Kristina Schoonjans; Bart Staels; Johan Auwerx
PPARgamma activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes.
Atherosclerosis 1998;137 Suppl():S75-80.
1998: Bart Staels; Johan Auwerx
Regulation of apo A-I gene expression by fibrates.
Atherosclerosis 1998;137 Suppl():S19-23.
1998: Anne-Marie Lefebvre; Martine Laville; N Vega; Jean-Paul Riou; L van Gaal; Johan Auwerx; Hubert Vidal
Depot-specific differences in adipose tissue gene expression in lean and obese subjects.
Diabetes 1998;47(1):98-103.
1997: Geneviève Martin; Kristina Schoonjans; Anne-Marie Lefebvre; Bart Staels; Johan Auwerx
Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators.
The Journal of biological chemistry 1997;272(45):28210-7.
1997: Jeffrey M Peters; Nathalie Hennuyer; Bart Staels; J C Fruchart; Catherine Fievet; Frank J Gonzalez; Johan Auwerx
Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice.
The Journal of biological chemistry 1997;272(43):27307-12.
1997: Anne-Marie Lefebvre; Julia Peinado-Onsurbe; I Leitersdorf; Michael R Briggs; J R Paterniti; Jean-Charles Fruchart; Catherine Fievet; Johan Auwerx; Bart Staels
Regulation of lipoprotein metabolism by thiazolidinediones occurs through a distinct but complementary mechanism relative to fibrates.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(9):1756-64.
1997: S Hallakou; L Doaré; Fabienne Foufelle; Micheline Kergoat; Michèle Guerre-Millo; Marie-France Berthault; Isabelle Dugail; Joëlle Morin; Johan Auwerx; Pascal Ferré
Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat.
Diabetes 1997;46(9):1393-9.
1997: D Auboeuf; Jennifer Rieusset; Lluis Fajas; Paulette Vallier; V Frering; Jean-Paul Riou; Bart Staels; Johan Auwerx; Martine Laville; Hubert Vidal
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients.
Diabetes 1997;46(8):1319-27.
1997: Lluis Fajas; D Auboeuf; Eric Raspé; Kristina Schoonjans; Anne-Marie Lefebvre; R Saladin; J Najib; Martine Laville; Jean-Charles Fruchart; Samir S Deeb; antonio vidal-puig; J Flier; Michael R Briggs; Bart Staels; Hubert Vidal; Johan Auwerx
The organization, promoter analysis, and expression of the human PPARgamma gene.
The Journal of biological chemistry 1997;272(30):18779-89.
1996: Kristina Schoonjans; Julia Peinado-Onsurbe; Anne-Marie Lefebvre; R A Heyman; M Briggs; Samir S Deeb; Bart Staels; Johan Auwerx
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene.
The EMBO journal 1996;15(19):5336-48.
1996: R Sabugal; M Q Robert; J Julve; Johan Auwerx; Miquel Llobera; Julia Peinado-Onsurbe
Hepatic regeneration induces changes in lipoprotein lipase activity in several tissues and its re-expression in the liver.
The Biochemical journal 1996;318 ( Pt 2)():597-602.
1996: J P Bossu; F L Chartier; Jean-Charles Fruchart; Johan Auwerx; Bart Staels; B Laine
Two regulatory elements of similar structure and placed in tandem account for the repressive activity of the first intron of the human apolipoprotein A-II gene.
The Biochemical journal 1996;318 ( Pt 2)():547-53.
1996: P De Vos; Anne-Marie Lefebvre; S G Miller; M Guerre-Millo; K Wong; R Saladin; L G Hamann; Bart Staels; M R Briggs; Johan Auwerx
Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma.
The Journal of clinical investigation 1996;98(4):1004-9.
1996: Bart Staels; Geneviève Martin; M Martinez; C Albert; Julia Peinado-Onsurbe; R Saladin; Dean W Hum; Manuel Reina; S Vilaro; Johan Auwerx
Expression and regulation of the lipoprotein lipase gene in human adrenal cortex.
The Journal of biological chemistry 1996;271(29):17425-32.
1996: Hubert Vidal; D Auboeuf; P De Vos; Bart Staels; Jean-Paul Riou; Johan Auwerx; Martine Laville
The expression of ob gene is not acutely regulated by insulin and fasting in human abdominal subcutaneous adipose tissue.
The Journal of clinical investigation 1996;98(2):251-5.
1996: R Saladin; Ngoc Vu-Dac; Jean-Charles Fruchart; Johan Auwerx; Bart Staels
Transcriptional induction of rat liver apolipoprotein A-I gene expression by glucocorticoids requires the glucocorticoid receptor and a labile cell-specific protein.
European journal of biochemistry / FEBS 1996;239(2):451-9.
1996: Johan Auwerx; Kristina Schoonjans; Jean-Charles Fruchart; Bart Staels
Transcriptional control of triglyceride metabolism: fibrates and fatty acids change the expression of the LPL and apo C-III genes by activating the nuclear receptor PPAR.
Atherosclerosis 1996;124 Suppl():S29-37.
1996: Ngoc Vu-Dac; Kristina Schoonjans; Vladimir Kosykh; J Dallongeville; R A Heyman; Bart Staels; Johan Auwerx
Retinoids increase human apolipoprotein A-11 expression through activation of the retinoid X receptor but not the retinoic acid receptor.
Molecular and cellular biology 1996;16(7):3350-60.
1996: S G Miller; P De Vos; M Guerre-Millo; K Wong; T Hermann; Bart Staels; M R Briggs; Johan Auwerx
The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(11):5507-11.
1996: Ricardo P Casaroli-Marano; Julia Peinado-Onsurbe; Manuel Reina; Bart Staels; Johan Auwerx; Senén Vilaró
Lipoprotein lipase in highly vascularized structures of the eye.
Journal of lipid research 1996;37(5):1037-44.
1996: R Buscà; M Martínez; Elisabet Vilella; P Pognonec; S Deeb; Johan Auwerx; Manuel Reina; Senén Vilaró
The mutation Gly142-->Glu in human lipoprotein lipase produces a missorted protein that is diverted to lysosomes.
The Journal of biological chemistry 1996;271(4):2139-46.
1995: R Saladin; P De Vos; M Guerre-Millo; A Leturque; J Girard; Bart Staels; Johan Auwerx
Transient increase in obese gene expression after food intake or insulin administration.
Nature 1995;377(6549):527-9.
1995: Kristina Schoonjans; M Watanabe; H Suzuki; Abderrahim Mahfoudi; G Krey; Walter Wahli; P Grimaldi; Bart Staels; T Yamamoto; Johan Auwerx
Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter.
The Journal of biological chemistry 1995;270(33):19269-76.
1995: Ngoc Vu-Dac; Kristina Schoonjans; Vladimir Kosykh; J Dallongeville; Jean-Charles Fruchart; Bart Staels; Johan Auwerx
Fibrates increase human apolipoprotein A-II expression through activation of the peroxisome proliferator-activated receptor.
The Journal of clinical investigation 1995;96(2):741-50.
1995: P De Vos; R Saladin; Johan Auwerx; Bart Staels
Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake.
The Journal of biological chemistry 1995;270(27):15958-61.
1995: R Buscà; Julia Peinado-Onsurbe; Elisabet Vilella; Johan Auwerx; Samir S Deeb; Senén Vilaró; Manuel Reina
The mutant Asn291-->Ser human lipoprotein lipase is associated with reduced catalytic activity and does not influence binding to heparin.
FEBS letters 1995;367(3):257-62.
1995: R Buscá; M A Pujana; P Pognonec; Johan Auwerx; Samir S Deeb; Manuel Reina; Senén Vilaró
Absence of N-glycosylation at asparagine 43 in human lipoprotein lipase induces its accumulation in the rough endoplasmic reticulum and alters this cellular compartment.
Journal of lipid research 1995;36(5):939-51.
1995: Bart Staels; Ngoc Vu-Dac; Vladimir Kosykh; R Saladin; Jean-Charles Fruchart; J Dallongeville; Johan Auwerx
Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates.
The Journal of clinical investigation 1995;95(2):705-12.
1994: Ngoc Vu-Dac; Kristina Schoonjans; B Laine; Jean-Charles Fruchart; Johan Auwerx; Bart Staels
Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
The Journal of biological chemistry 1994;269(49):31012-8.
1994: Gail P Jarvik; Melissa A Austin; R R Fabsitz; Johan Auwerx; T Reed; J C Christian; S Deeb
Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects.
Genetic epidemiology 1994;11(4):375-84.
1993: Kristina Schoonjans; Bart Staels; P Grimaldi; Johan Auwerx
Acyl-CoA synthetase mRNA expression is controlled by fibric-acid derivatives, feeding and liver proliferation.
European journal of biochemistry / FEBS 1993;216(2):615-22.
1993: P van Dijck; K Schoonjans; P Sassone-Corsi; Johan Auwerx; G Verhoeven
A Fos-Jun element in the first intron of an alpha 2u-globulin gene.
Molecular and cellular biochemistry 1993;125(2):127-36.
1993: Kristina Schoonjans; Bart Staels; P Devos; J Szpirer; Claude Szpirer; Samir S Deeb; G Verhoeven; Johan Auwerx
Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site.
FEBS letters 1993;329(1-2):89-95.
1993: Julia Peinado-Onsurbe; Bart Staels; D Vanderschueren; R Bouillon; Johan Auwerx
Effects of sex steroids on hepatic and lipoprotein lipase activity and mRNA in the rat.
Hormone research 1993;40(5-6):184-8.
1992: Johan Auwerx; P Sassone-Corsi
AP-1 (Fos-Jun) regulation by IP-1: effect of signal transduction pathways and cell growth.
Oncogene 1992;7(11):2271-80.
1992: Hans Jansen; Arie Van Tol; Johan Auwerx; G Skretting; Bart Staels
Opposite regulation of hepatic lipase and lecithin: cholesterol acyltransferase by glucocorticoids in rats.
Biochimica et biophysica acta 1992;1128(2-3):181-5.
1992: Julia Peinado-Onsurbe; Bart Staels; Samir S Deeb; Johan Auwerx
Lipoprotein lipase expression in undifferentiated hepatoma cells is regulated by progesterone and protein kinase A.
Biochemistry 1992;31(41):10121-8.
1992: Bart Staels; Johan Auwerx
Perturbation of developmental gene expression in rat liver by fibric acid derivatives: lipoprotein lipase and alpha-fetoprotein as models.
Development (Cambridge, England) 1992;115(4):1035-43.
1992: K A Descheemaeker; S Wyns; Luc Nelles; Johan Auwerx; T Ny; Désiré Collen
Interaction of AP-1-, AP-2-, and Sp1-like proteins with two distinct sites in the upstream regulatory region of the plasminogen activator inhibitor-1 gene mediates the phorbol 12-myristate 13-acetate response.
The Journal of biological chemistry 1992;267(21):15086-91.
1992: Julia Peinado-Onsurbe; Bart Staels; Samir S Deeb; I Ramirez; Miquel Llobera; Johan Auwerx
Neonatal extinction of liver lipoprotein lipase expression.
Biochimica et biophysica acta 1992;1131(3):281-6.
1992: Johan Auwerx; Roger Bouillon; Hugo E C Kesteloot
Relation between 25-hydroxyvitamin D3, apolipoprotein A-I, and high density lipoprotein cholesterol.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(6):671-4.
1992: Bart Staels; Arie Van Tol; G Skretting; Johan Auwerx
Lecithin:cholesterol acyltransferase gene expression is regulated in a tissue-selective manner by fibrates.
Journal of lipid research 1992;33(5):727-35.
1992: Bart Staels; Arie Van Tol; T Andreu; Johan Auwerx
Fibrates influence the expression of genes involved in lipoprotein metabolism in a tissue-selective manner in the rat.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(3):286-94.
1992: Bart Staels; Julia Peinado-Onsurbe; Johan Auwerx
Down-regulation of hepatic lipase gene expression and activity by fenofibrate.
Biochimica et biophysica acta 1992;1123(2):227-30.
1992: Johan Auwerx; B Staels; F Van Vaeck; Jan L Ceuppens
Changes in IgG Fc receptor expression induced by phorbol 12-myristate 13-acetate treatment of THP-1 monocytic leukemia cells.
Leukemia research 1992;16(3):317-27.
1992: Johan Auwerx; P Leroy; Kristina Schoonjans
Lipoprotein lipase: recent contributions from molecular biology.
Critical reviews in clinical laboratory sciences 1992;29(3-4):243-68.
1992: Johan Auwerx
Regulation of gene expression by fatty acids and fibric acid derivatives: an integrative role for peroxisome proliferator activated receptors. The Belgian Endocrine Society Lecture 1992.
Hormone research 1992;38(5-6):269-77.
1991: Bart Staels; Arie Van Tol; H Jansen; Johan Auwerx
The effects of probucol on lipoprotein metabolism in the rat.
Biochimica et biophysica acta 1991;1085(1):131-5.
1991: Bart Staels; Arie Van Tol; L Chan; Guido Verhoeven; Johan Auwerx
Variable effects of different corticosteroids on plasma lipids, apolipoproteins, and hepatic apolipoprotein mRNA levels in rats.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(3):760-9.
1991: Marc Van Ranst; K Norga; S Masure; Paul Proost; F Vandekerckhove; Johan Auwerx; Jo Van Damme; Ghislain Opdenakker
The cytokine-protease connection: identification of a 96-kD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers.
Cytokine 1991;3(3):231-9.
1990: Bart Staels; Arie Van Tol; L Chan; H Will; Guido Verhoeven; Johan Auwerx
Alterations in thyroid status modulate apolipoprotein, hepatic triglyceride lipase, and low density lipoprotein receptor in rats.
Endocrinology 1990;127(3):1144-52.
1990: Bart Staels; H Jansen; Arie Van Tol; G Stahnke; H Will; Guido Verhoeven; Johan Auwerx
Development, food intake, and ethinylestradiol influence hepatic triglyceride lipase and LDL-receptor mRNA levels in rats.
Journal of lipid research 1990;31(7):1211-8.
1990: Bart Staels; Arie Van Tol; Guido Verhoeven; Johan Auwerx
Apolipoprotein A-IV messenger ribonucleic acid abundance is regulated in a tissue-specific manner.
Endocrinology 1990;126(4):2153-63.
1990: Johan Auwerx; S P Babirak; JE Hokanson; G Stahnke; H Will; Samir S Deeb; John D Brunzell
Coexistence of abnormalities of hepatic lipase and lipoprotein lipase in a large family.
American journal of human genetics 1990;46(3):470-7.
1990: Johan Auwerx; B Staels; P Sassone-Corsi
Coupled and uncoupled induction of fos and jun transcription by different second messengers in cells of hematopoietic origin.
Nucleic acids research 1990;18(2):221-8.
1989: Johan Auwerx; Alan Chait; Gertrud Wolfbauer; Samir S Deeb
Loss of copper-zinc superoxide dismutase gene expression in differentiated cells of myelo-monocytic origin.
Blood 1989;74(5):1807-10.
1989: Johan Auwerx; S P Babirak; W Y Fujimoto; P H Iverius; John D Brunzell
Defective enzyme protein in lipoprotein lipase deficiency.
European journal of clinical investigation 1989;19(5):433-7.
1989: Bart Staels; Johan Auwerx; L Chan; Arie Van Tol; M Rosseneu; Guido Verhoeven
Influence of development, estrogens, and food intake on apolipoprotein A-I, A-II, and E mRNA in rat liver and intestine.
Journal of lipid research 1989;30(8):1137-45.
1989: Johan Auwerx; Alan Chait; Gertrud Wolfbauer; Samir S Deeb
Involvement of second messengers in regulation of the low-density lipoprotein receptor gene.
Molecular and cellular biology 1989;9(6):2298-302.
1989: Johan Auwerx; S Deeb; John D Brunzell; Gertrud Wolfbauer; Alan Chait
Lipoprotein lipase gene expression in THP-1 cells.
Biochemistry 1989;28(11):4563-7.
1989: Johan Auwerx; C A Marzetta; JE Hokanson; John D Brunzell
Large buoyant LDL-like particles in hepatic lipase deficiency.
Arteriosclerosis (Dallas, Tex.) 1989;9(3):319-25.
1989: Johan Auwerx; Alan Chait; Samir S Deeb
Regulation of the low density lipoprotein receptor and hydroxymethylglutaryl coenzyme A reductase genes by protein kinase C and a putative negative regulatory protein.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(4):1133-7.
1988: Johan Auwerx; S Deeb; John D Brunzell; R Peng; Alan Chait
Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines.
Biochemistry 1988;27(8):2651-5.
1988: Johan Auwerx; J Dequeker; Roger Bouillon; Piet Geusens; Jos Nijs
Mineral metabolism and bone mass at peripheral and axial skeleton in diabetes mellitus.
Diabetes 1988;37(1):8-12.
1988: Johan Auwerx; Roger Bouillon; Désiré Collen; J Geboers
Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus.
Arteriosclerosis (Dallas, Tex.) 1988;8(1):68-72.