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Hiroko Ikeda

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Akihiko Takeuchi; Hiroko Ikeda; Hiroaki Kimura; Hideji Nishida; Norio Yamamoto; Hiroyuki Tsuchiya
Complete Necrosis of a Giant Cell Tumor with High Expression of PPARγ: A Case Report.
Kenichi Harada; Maylee Hsu; Saya Igarashi; Hiroko Ikeda; Yasunori Sato; Yasuni Nakanuma
Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours.
Chihiro Gandou; Kenichi Harada; Saya Igarashi; Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules.

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2013: Akihiko Takeuchi; Hiroko Ikeda; Hiroaki Kimura; Hideji Nishida; Norio Yamamoto; Hiroyuki Tsuchiya
Complete Necrosis of a Giant Cell Tumor with High Expression of PPARγ: A Case Report.
Anticancer research 2013;33(5):2169-74.
2013: Kenichi Harada; Maylee Hsu; Saya Igarashi; Hiroko Ikeda; Yasunori Sato; Yasuni Nakanuma
Notch1-Hes1 signalling axis in the tumourigenesis of biliary neuroendocrine tumours.
Journal of clinical pathology 2013;66(5):386-91.
2013: Chihiro Gandou; Kenichi Harada; Saya Igarashi; Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules.
Human pathology 2013;44(5):811-21.
2013: Hirohide Sato; Yasunori Sato; Kazuto Kozaka; Yasuni Nakanuma; Hiroko Ikeda
Spread of hilar cholangiocarcinomas via peribiliary gland network: a hither-to-unrecognized route of periductal infiltration.
International journal of clinical and experimental pathology 2013;6(2):318-22.
2013: Isao Matsumoto; Takafumi Mochizuki; Kenichi Nakajima; Makoto Oda; Masaya Takizawa; Ryuichi Waseda; Hiroko Ikeda; Masaya Kawano; Go Watanabe
Usefulness of fluorine-18 fluorodeoxyglucose-positron emission tomography in management strategy for thymic epithelial tumors.
The Annals of thoracic surgery 2013;95(1):305-10.
2012: Yasuni Nakanuma; Young Nyun Park; Kenji Sano; Yasunori Sato; Takeshi Uehara; Masakazu Yamamoto; Shunichi Ariizumi; Joon Hyuk Choi; Kenichi Harada; Hiroko Ikeda; Mikiko Kobayashi; Ensil Yu
Intrahepatic cholangiocarcinoma with predominant "ductal plate malformation" pattern: a new subtype.
The American journal of surgical pathology 2012;36(11):1629-35.
2012: Saya Igarashi; Hiroko Ikeda; Takashi Matsubara; Osamu Matsui; Motoko Sasaki; Yasunori Sato; Kenichi Harada; Yasuni Nakanuma
Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis.
Histopathology 2012;61(2):266-76.
2012: Jing Xu; Norihide Yoneda; Eunsil Yu; Motoko Sasaki; Saya Igarashi; Hiroko Ikeda; Jihun Kim; Kazuto Kozaka; Takashi Matsubara; Osamu Matsui; Yasuni Nakanuma
Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers.
Liver international : official journal of the International Association for the Study of the Liver 2012;32(7):1156-64.
2012: Kenichi Harada; Saya Igarashi; Hiroko Ikeda; Yasushi Kimura; Xiang-Shan Ren; Hirohide Sato; Yasunori Sato; Shinji Shimoda; Yasuni Nakanuma
Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: molecular mechanism of IgG4 reaction in cancer tissue.
Hepatology (Baltimore, Md.) 2012;56(1):157-64.
2012: Kenichi Harada; Saya Igarashi; Hiroko Ikeda; Shinji Masuda; Hsu Maylee; Atsushi Okamura; Yasunori Sato; Yasuni Nakanuma
Clinicopathologic study of mixed adenoneuroendocrine carcinomas of hepatobiliary organs.
Virchows Archiv : an international journal of pathology 2012;460(3):281-9.
2012: Masayo Kimura; Akira Nishimura; Yoshiaki Saito; Hiroko Ikeda; Kazuhisa Sugiyama
Retinotomy with retinal turnover to remove subretinal membranes under direct visualization for proliferative vitreoretinopathy.
Clinical ophthalmology (Auckland, N.Z.) 2012;6():781-8.
2011: Kenichi Harada; Maylee Hsu; Saya Igarashi; Hiroko Ikeda; Satomi Kasashima; Atsuhiro Kawashima; Hajime Ohta; Atsushi Okamura; Xiang Shan Ren; Yasunori Sato; Mayumi Chiba; Yasuni Nakanuma
Monocyte chemoattractant protein-1 derived from biliary innate immunity contributes to hepatic fibrogenesis.
Journal of clinical pathology 2011;64(8):660-5.
2011: Mayumi Chiba; Hiroko Ikeda; Seiko Kitamura; Motoko Sasaki; Yasunori Sato; Yasuni Nakanuma
Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease.
Journal of clinical pathology 2011;64(7):564-70.
2011: Yasuni Nakanuma; Yuko Kakuda; Kenichi Harada; Hiroko Ikeda
[Pathology of chronic viral hepatitis C].
Nihon rinsho. Japanese journal of clinical medicine 2011;69 Suppl 4():165-72.
2011: Yasuni Nakanuma; Jing Xu; Kenichi Harada; Yasunori Sato; Motoko Sasaki; Hiroko Ikeda; Jihun Kim; Eunsil Yu
Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases.
Pathology international 2011;61(5):298-305.
2011: Kenichi Harada; Shinji Shimoda; Hiroko Ikeda; Mayumi Chiba; Maylee Hsu; Yasunori Sato; Mio Kobayashi; Xiang Shan Ren; Hajime Ohta; Satomi Kasashima; Atsuhiro Kawashima; Yasuni Nakanuma
Significance of periductal Langerhans cells and biliary epithelial cell-derived macrophage inflammatory protein-3α in the pathogenesis of primary biliary cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver 2011;31(2):245-53.
2011: Norihide Yoneda; Yasunori Sato; Azusa Kitao; Hiroko Ikeda; Seiko Sawada-Kitamura; Masami Miyakoshi; Kenichi Harada; Motoko Sasaki; Osamu Matsui; Yasuni Nakanuma
Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2011;91(2):262-72.
2010: Yasuni Nakanuma; Yasunori Sato; Kenichi Harada; Motoko Sasaki; Jing Xu; Hiroko Ikeda
Pathological classification of intrahepatic cholangiocarcinoma based on a new concept.
World journal of hepatology 2010;2(12):419-27.
2010: Yasunori Sato; Kenichi Harada; Keita Itatsu; Hiroko Ikeda; Yuko Kakuda; Syuji Shimomura; Xiang Shan Ren; Norihide Yoneda; Motoko Sasaki; Yasuni Nakanuma
Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma.
The American journal of pathology 2010;177(1):141-52.
2010: Akira Funada; Eiichi Masuta; Noboru Fujino; Kenshi Hayashi; Hidekazu Ino; Yoshihito Kita; Hiroko Ikeda; Takahiko Fujii; Yasuni Nakanuma; Masakazu Yamagishi
Heterogeneity of clinical manifestation of hypertrophic cardiomyopathy caused by deletion of lysine 183 in cardiac troponin I gene.
International heart journal 2010;51(3):214-7.
2010: Yasuni Nakanuma; Yoh Zen; Kenichi Harada; Hiroko Ikeda; Yasunori Sato; Takeshi Uehara; Motoko Sasaki
Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach.
Journal of hepato-biliary-pancreatic sciences 2010;17(3):211-22.
2010: Motoko Sasaki; Hiroko Ikeda; Junpei Yamaguchi; Masami Miyakoshi; Yasunori Sato; Yasuni Nakanuma
Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression.
American journal of clinical pathology 2010;133(2):212-23.
2010: Yasuni Nakanuma; Kenichi Harada; Yasunori Sato; Hiroko Ikeda
Recent progress in the etiopathogenesis of pediatric biliary disease, particularly Caroli's disease with congenital hepatic fibrosis and biliary atresia.
Histology and histopathology 2010;25(2):223-35.
2010: Junpei Yamaguchi; Motoko Sasaki; Yasunori Sato; Keita Itatsu; Kenichi Harada; Yoh Zen; Hiroko Ikeda; Yuji Nimura; Masato Nagino; Yasuni Nakanuma
Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma.
Cancer science 2010;101(2):355-62.
2009: Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Kenichi Harada; Yoh Zen; Takeshi Mitsui; Yasuni Nakanuma
Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion.
Human pathology 2009;40(12):1774-82.
2009: Motoko Sasaki; Junpei Yamaguchi; Hiroko Ikeda; Keita Itatsu; Yasuni Nakanuma
Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies.
Human pathology 2009;40(12):1723-30.
2009: Yasuni Nakanuma; Motoko Sasaki; Yasunori Sato; Xiangshan Ren; Hiroko Ikeda; Kenichi Harada
Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts.
World journal of hepatology 2009;1(1):35-42.
2009: Junpei Yamaguchi; Motoko Sasaki; Kenichi Harada; Yoh Zen; Yasunori Sato; Hiroko Ikeda; Keita Itatsu; Yukihiro Yokoyama; Hisami Ando; Tetsuo Ohta; Akio Kubota; Koichi Shimizu; Yuji Nimura; Masato Nagino; Yasuni Nakanuma
Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin.
Laboratory investigation; a journal of technical methods and pathology 2009;89(9):1018-31.
2009: Manabu Onodera; Yasunori Sato; Hiroko Ikeda; Yoh Zen; Seisyo Sakai; Masao Syoji; Koya Sakamoto; Takashi Tani; Masahiro Asaka; Yasuni Nakanuma
Biliary deposition of Liesegang rings presenting as a polypoid mass in the liver: previously unrecognized lesion.
Pathology international 2009;59(8):577-82.
2009: Kenichi Harada; Shinji Shimoda; Yasunori Sato; Kumiko Isse; Hiroko Ikeda; Yasuni Nakanuma
Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis.
Clinical and experimental immunology 2009;157(2):261-70.
2009: Hiroko Ikeda; Motoko Sasaki; Yasunori Sato; Kenichi Harada; Yoh Zen; Takeshi Mitsui; Yasuni Nakanuma
Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis.
Pathology international 2009;59(7):471-8.
2009: Kenichi Harada; Yasunori Sato; Hiroko Ikeda; Kumiko Isse; Satoru Ozaki; Mio Enomae; Kazunori Ohama; Kazuyoshi Katayanagi; Hiroshi Kurumaya; Akira Matsui; Yasuni Nakanuma
Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia.
The Journal of pathology 2009;217(5):654-64.
2009: Keita Itatsu; Motoko Sasaki; Junpei Yamaguchi; Shusaku Ohira; Akira Ishikawa; Hiroko Ikeda; Yasunori Sato; Kenichi Harada; Yoh Zen; Hiroshi Sato; Tetsuo Ohta; Masato Nagino; Yuji Nimura; Yasuni Nakanuma
Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha.
The American journal of pathology 2009;174(3):829-41.
2009: Yasunori Sato; Kenichi Harada; Hiroko Ikeda; Takahiko Fijii; Motoko Sasaki; Yoh Zen; Yasuni Nakanuma
Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver--a potential mechanism of central scar formation.
Human pathology 2009;40(2):181-8.
2009: Keita Itatsu; Motoko Sasaki; Kenichi Harada; Junpei Yamaguchi; Hiroko Ikeda; Yasunori Sato; Tetsuo Ohta; Hiroshi Sato; Masato Nagino; Yuji Nimura; Yasuni Nakanuma
Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha.
Liver international : official journal of the International Association for the Study of the Liver 2009;29(2):291-8.
2009: Koushiro Ohtsubo; Hiroyuki Watanabe; Tadaaki Yamada; Tomoya Tsuchiyama; Hisatsugu Mouri; Kaname Yamashita; Kazuo Yasumoto; Hiroko Ikeda; Yasuni Nakanuma; Seiji Yano
Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsy.
Internal medicine (Tokyo, Japan) 2009;48(18):1651-6.
2008: Motoko Sasaki; Hiroko Ikeda; Keita Itatsu; Junpei Yamaguchi; Seiko Sawada; Hiroshi Minato; Tetsuo Ohta; Yasuni Nakanuma
The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma.
Laboratory investigation; a journal of technical methods and pathology 2008;88(8):873-82.
2008: Motoko Sasaki; Hiroko Ikeda; Yasuni Nakanuma
Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study.
Journal of autoimmunity 2008;31(1):73-8.
2008: Motoko Sasaki; Hiroko Ikeda; Yasunori Sato; Yasuni Nakanuma
Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study.
Free radical research 2008;42(7):625-32.
2008: Motoko Sasaki; Hiroko Ikeda; Junpei Yamaguchi; Satoko Nakada; Yasuni Nakanuma
Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence.
Hepatology (Baltimore, Md.) 2008;48(1):186-95.
2008: Motoko Sasaki; J Yamaguchi; Keita Itatsu; Hiroko Ikeda; Yasuni Nakanuma
Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis.
The Journal of pathology 2008;215(2):175-83.
2008: Kenichi Harada; Yasunori Sato; Kumiko Isse; Hiroko Ikeda; Yasuni Nakanuma
Induction of innate immune response and absence of subsequent tolerance to dsRNA in biliary epithelial cells relate to the pathogenesis of biliary atresia.
Liver international : official journal of the International Association for the Study of the Liver 2008;28(5):614-21.
2008: Keita Itatsu; Yoh Zen; Junpei Yamaguchi; Shusaku Ohira; Akira Ishikawa; Hiroko Ikeda; Yasunori Sato; Kenichi Harada; Motoko Sasaki; Masatoshi Sasaki; Hiroya Sakamoto; Masato Nagino; Yuji Nimura; Tetsuo Ohta; Yasuni Nakanuma
Expression of matrix metalloproteinase 7 is an unfavorable postoperative prognostic factor in cholangiocarcinoma of the perihilar, hilar, and extrahepatic bile ducts.
Human pathology 2008;39(5):710-9.
2008: Yasuni Nakanuma; Motoko Sasaki; Hiroko Ikeda; Yasunori Sato; Yoh Zen; Kazuto Kosaka; Kenichi Harada
Pathology of peripheral intrahepatic cholangiocarcinoma with reference to tumorigenesis.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(4):325-34.
2008: Yumie Takeshita; Toshinari Takamura; Hiroshi Minato; Hirofumi Misu; Hitoshi Ando; Tatsuya Yamashita; Hiroko Ikeda; Yasuni Nakanuma; Shuichi Kaneko
Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy.
Internal medicine (Tokyo, Japan) 2008;47(19):1709-12.
2007: Yasunori Sato; Kenichi Harada; Satoru Ozaki; Shinichi Furubo; Kazuo Kizawa; Takahiro Sanzen; Mitsue Yasoshima; Hiroko Ikeda; Motoko Sasaki; Yasuni Nakanuma
Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat.
The American journal of pathology 2007;171(6):1859-71.
2007: Keita Itatsu; Yoh Zen; Shusaku Ohira; Akira Ishikawa; Yasunori Sato; Kenichi Harada; Hiroko Ikeda; Motoko Sasaki; Yuji Nimura; Yasuni Nakanuma
Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis.
Liver international : official journal of the International Association for the Study of the Liver 2007;27(9):1174-84.
2007: Kenichi Harada; Yasunori Sato; Keita Itatsu; Kumiko Isse; Hiroko Ikeda; Mitsue Yasoshima; Yoh Zen; Akira Matsui; Yasuni Nakanuma
Innate immune response to double-stranded RNA in biliary epithelial cells is associated with the pathogenesis of biliary atresia.
Hepatology (Baltimore, Md.) 2007;46(4):1146-54.
2007: Motoko Sasaki; Hiroko Ikeda; Seiko Sawada; Yasunori Sato; Yasuni Nakanuma
Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis.
Journal of clinical pathology 2007;60(10):1102-7.
2007: Hiroko Ikeda; Motoko Sasaki; Akira Ishikawa; Yasunori Sato; Kenichi Harada; Yoh Zen; Hideaki Kazumori; Yasuni Nakanuma
Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture.
Laboratory investigation; a journal of technical methods and pathology 2007;87(6):559-71.
2007: Motoko Sasaki; Hiroko Ikeda; Yasuni Nakanuma
Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance.
Progress in histochemistry and cytochemistry 2007;42(2):61-110.
2006: Motoko Sasaki; Hiroko Ikeda; Hiroaki Kataoka; Yasuni Nakanuma
Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis.
Virchows Archiv : an international journal of pathology 2006;449(4):462-71.
2006: Motoko Sasaki; Hiroko Ikeda; Yasunori Sato; Yasuni Nakanuma
Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis.
The American journal of pathology 2006;169(3):831-45.
2005: Tomoya Kaneda; Masami Shimizu; Hidekazu Ino; Hidenobu Terai; Noboru Fujino; Katsuharu Uchiyama; Tomohito Mabuchi; Tetsuo Konno; Takashi Fujita; Eichi Masuda; Hiromasa Kato; Akira Funada; Hiroshi Mabuchi; Hiroko Ikeda
Images in cardiovascular medicine. Adult patient with isolated noncompaction of ventricular myocardium.
Circulation 2005;112(7):e96-7.
2005: Motoko Sasaki; Hiroko Ikeda; Hironori Haga; Toshiaki Manabe; Yasuni Nakanuma
Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.
The Journal of pathology 2005;205(4):451-9.
2004: Motoko Sasaki; Hiroko Ikeda; Shusaku Ohira; Akira Ishikawa; Yasuni Nakanuma
Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis.
Peptides 2004;25(5):763-70.