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Joh-E Ikeda

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Takuya Kanno; Kazunori Tanaka; Yoshiko Yanagisawa; Kaori Yasutake; Fumihito Yoshii; Shinji Hadano; Noriaki Hirayama; Joh-E Ikeda
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
Kazunori Tanaka; Yoshiko Yanagisawa; Kaori Yasutake; Fumihito Yoshii; Shinji Hadano; Takuya Kanno; Joh-E Ikeda
Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.
Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Joh-E Ikeda; Shinji Hadano
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation.

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2012: Takuya Kanno; Kazunori Tanaka; Yoshiko Yanagisawa; Kaori Yasutake; Fumihito Yoshii; Shinji Hadano; Noriaki Hirayama; Joh-E Ikeda
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS.
Free radical biology & medicine 2012;53(11):2028-42.
2011: Kazunori Tanaka; Yoshiko Yanagisawa; Kaori Yasutake; Fumihito Yoshii; Shinji Hadano; Takuya Kanno; Joh-E Ikeda
Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.
Experimental neurology 2011;232(1):41-52.
2011: Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Joh-E Ikeda; Shinji Hadano
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation.
FEBS letters 2011;585(5):730-6.
2010: Shinji Hadano; Yasuhiro Yoshii; Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Lei Pan; Shigeru Kakuta; Yasuo Iwasaki; Yoichiro Iwakura; Joh-E Ikeda
Genetic background and gender effects on gross phenotypes in congenic lines of ALS2/alsin-deficient mice.
Neuroscience research 2010;68(2):131-6.
2010: Shinji Hadano; Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Akira Akatsuka; Masato Koike; Masashi Aoki; Yasuo Uchiyama; Yasuto Itoyama; Joh-E Ikeda
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking.
PloS one 2010;5(3):e9805.
2008: Kazunori Tanaka; Yoshinori Okada; Takuya Kanno; Asako Otomo; Yoshiko Yanagisawa; Junko Shouguchi-Miyata; Etsuko Suga; Eri Kohiki; Kyuichiro Onoe; Hitoshi Osuga; Masashi Aoki; Shinji Hadano; Yasuto Itoyama; Joh-E Ikeda
A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.
Experimental neurology 2008;211(2):378-86.
2008: Asako Otomo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Hikaru Mizumura; Kyuichiro Onoe; Hitoshi Osuga; Shinji Hadano; Joh-E Ikeda
ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth.
Biochemical and biophysical research communications 2008;370(1):87-92.
2007: Shinji Hadano; Ryota Kunita; Asako Otomo; Kyoko Suzuki-Utsunomiya; Joh-E Ikeda
Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.
Neurochemistry international 2007;51(2-4):74-84.
2007: Ryota Kunita; Asako Otomo; Hikaru Mizumura; Kyoko Suzuki-Utsunomiya; Shinji Hadano; Joh-E Ikeda
The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis.
The Journal of biological chemistry 2007;282(22):16599-611.
2007: Kyoko Suzuki-Utsunomiya; Shinji Hadano; Asako Otomo; Ryota Kunita; Hikaru Mizumura; Hitoshi Osuga; Joh-E Ikeda
ALS2CL, a novel ALS2-interactor, modulates ALS2-mediated endosome dynamics.
Biochemical and biophysical research communications 2007;354(2):491-7.
2006: Kazunori Tanaka; Natsuki Miyamoto; Junko Shouguchi-Miyata; Joh-E Ikeda
HFM1, the human homologue of yeast Mer3, encodes a putative DNA helicase expressed specifically in germ-line cells.
DNA sequence : the journal of DNA sequencing and mapping 2006;17(3):242-6.
2006: Eimei Sato; Naoko Kimura; Masaki Yokoo; Yuko Miyake; Joh-E Ikeda
Morphodynamics of ovarian follicles during oogenesis in mice.
Microscopy research and technique 2006;69(6):427-35.
2006: Shinji Hadano; Susanna C Benn; Shigeru Kakuta; Asako Otomo; Katsuko Sudo; Ryota Kunita; Kyoko Suzuki-Utsunomiya; Hikaru Mizumura; Jeremy M Shefner; Gregory A Cox; Yoichiro Iwakura; Robert H Brown; Joh-E Ikeda
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking.
Human molecular genetics 2006;15(2):233-50.
2005: Yoshinori Okada; Harumi Sakai; Eri Kohiki; Etsuko Suga; Yoshiko Yanagisawa; Kazunori Tanaka; Shinji Hadano; Hitoshi Osuga; Joh-E Ikeda
A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2005;25(7):794-806.
2005: Shinji Hadano; Joh-E Ikeda
Purification and functional analyses of ALS2 and its homologue.
Methods in enzymology 2005;403():310-21.
2004: Joh-E Ikeda
[Recessive motor neuron diseases: mutations in the ALS2 gene and molecular pathogenesis for the upper motor neurodegeneration].
Rinshō shinkeigaku = Clinical neurology 2004;44(11):792-4.
2004: Shinji Hadano; Asako Otomo; Kyoko Suzuki-Utsunomiya; Ryota Kunita; Yoshiko Yanagisawa; Junko Showguchi-Miyata; Hikaru Mizumura; Joh-E Ikeda
ALS2CL, the novel protein highly homologous to the carboxy-terminal half of ALS2, binds to Rab5 and modulates endosome dynamics.
FEBS letters 2004;575(1-3):64-70.
2004: Ryota Kunita; Asako Otomo; Hikaru Mizumura; Kyoko Suzuki; Junko Showguchi-Miyata; Yoshiko Yanagisawa; Shinji Hadano; Joh-E Ikeda
Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking.
The Journal of biological chemistry 2004;279(37):38626-35.
2004: Christopher J Storbeck; Suzana Drmanic; Kate Daniel; James D Waring; Frank R Jirik; David J Parry; Nazim Ahmed; Luc A Sabourin; Joh-E Ikeda; Robert G Korneluk
Inhibition of myogenesis in transgenic mice expressing the human DMPK 3'-UTR.
Human molecular genetics 2004;13(6):589-600.
2004: Kazunori Tanaka; Junko Shouguchi-Miyata; Natsuki Miyamoto; Joh-E Ikeda
Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene.
The Journal of biological chemistry 2004;279(8):7275-86.
2003: Asako Otomo; Shinji Hadano; Takeya Okada; Hikaru Mizumura; Ryota Kunita; Hitoshi Nishijima; Junko Showguchi-Miyata; Yoshiko Yanagisawa; Eri Kohiki; Etsuko Suga; Masanori Yasuda; Hitoshi Osuga; Takeharu Nishimoto; Shuh Narumiya; Joh-E Ikeda
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics.
Human molecular genetics 2003;12(14):1671-87.
2003: Isao Nagano; Tetsuro Murakami; Mito Shiote; Yasuhiro Manabe; Shinji Hadano; Yoshiko Yanagisawa; Joh-E Ikeda; Koji Abe
Single-nucleotide polymorphisms in uncoding regions of ALS2 gene of Japanese patients with autosomal-recessive amyotrophic lateral sclerosis.
Neurological research 2003;25(5):505-9.
2002: Ryota Kunita; Asako Otomo; Joh-E Ikeda
Identification and characterization of novel members of the CREG family, putative secreted glycoproteins expressed specifically in brain.
Genomics 2002;80(5):456-60.
2002: Roshni R Singaraja; Shinji Hadano; Martina Metzler; Scott Givan; Cheryl L Wellington; Simon Warby; Anat Yanai; Claire-Anne Gutekunst; Blair R Leavitt; Hong Yi; Keith Fichter; Lu Gan; Krista McCutcheon; Vikramjit Chopra; Jennifer Michel; Steven M Hersch; Joh-E Ikeda; Michael R Hayden
HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis.
Human molecular genetics 2002;11(23):2815-28.
2002: Takeya Okada; Yoichi Gondo; Jun Goto; Ichiro Kanazawa; Shinji Hadano; Joh-E Ikeda
Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.
Human genetics 2002;110(4):302-13.
2002: Ming Xu; Takeya Okada; Harumi Sakai; Natsuki Miyamoto; Yoshiko Yanagisawa; Alex E MacKenzie; Shinji Hadano; Joh-E Ikeda
Functional human NAIP promoter transcription regulatory elements for the NAIP and PsiNAIP genes.
Biochimica et biophysica acta 2002;1574(1):35-50.
2002: Fuhu Wang; Dale Corbett; Hitoshi Osuga; Sachiko Osuga; Joh-E Ikeda; ruth slack; Matthew J Hogan; Antoine M Hakim; David Park
Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002;22(2):171-82.
2001: Masaki Uchida; Yoshiki Shimatsu; K Onoe; N Matsuyama; Rikio Niki; Joh-E Ikeda; Hiroshi Imai
Production of transgenic miniature pigs by pronuclear microinjection.
Transgenic research 2001;10(6):577-82.
2001: Shinji Hadano; Collette K Hand; Hitoshi Osuga; Yoshiko Yanagisawa; Asako Otomo; Rebecca S Devon; N Miyamoto; Junko Showguchi-Miyata; Y Okada; Roshni R Singaraja; D A Figlewicz; T Kwiatkowski; B A Hosler; Tally Lerman-Sagie; Jennifer Skaug; Jamal Nasir; R H Brown; Stephen W Scherer; Guy Rouleau; Michael R Hayden; Joh-E Ikeda
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2.
Nature genetics 2001;29(2):166-73.
2000: N Matsuyama; Shinji Hadano; K Onoe; Hitoshi Osuga; Junko Showguchi-Miyata; Yoichi Gondo; Joh-E Ikeda
Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat.
Genomics 2000;69(1):72-85.
2000: Hitoshi Osuga; Sachiko Osuga; F Wang; raouf fetni; M J Hogan; ruth slack; Antoine M Hakim; Joh-E Ikeda; David Park
Cyclin-dependent kinases as a therapeutic target for stroke.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(18):10254-9.
2000: Y Saitoh; N Miyamoto; Takeya Okada; Yoichi Gondo; Junko Showguchi-Miyata; Shinji Hadano; Joh-E Ikeda
The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.
Genomics 2000;67(3):291-300.
1999: K Yamamoto; H Sakai; Shinji Hadano; Yoichi Gondo; Joh-E Ikeda
Identification of two distinct transcripts for the neuronal apoptosis inhibitory protein gene.
Biochemical and biophysical research communications 1999;264(3):998-1006.
1999: K Matsumoto; T Nakayama; Harumi Sakai; K Tanemura; Hitoshi Osuga; E Sato; Joh-E Ikeda
Neuronal apoptosis inhibitory protein (NAIP) may enhance the survival of granulosa cells thus indirectly affecting oocyte survival.
Molecular reproduction and development 1999;54(2):103-11.
1999: Shinji Hadano; Jamal Nasir; K Nichol; Dita M Rasper; John P Vaillancourt; S W Sherer; B G Beatty; Joh-E Ikeda; Donald W Nicholson; Michael R Hayden
Genomic organization of the human caspase-9 gene on Chromosome 1p36. 1-p36.3.
Mammalian genome : official journal of the International Mammalian Genome Society 1999;10(7):757-60.
1999: Shinji Hadano; K Nichol; Ryan R Brinkman; Jamal Nasir; Duane W Martindale; BF Koop; Donald W Nicholson; Stephen W Scherer; Joh-E Ikeda; Michael R Hayden
A yeast artificial chromosome-based physical map of the juvenile amyotrophic lateral sclerosis (ALS2) critical region on human chromosome 2q33-q34.
Genomics 1999;55(1):106-12.
1998: Yoichi Gondo; Takeya Okada; N Matsuyama; Y Saitoh; Yoshiko Yanagisawa; Joh-E Ikeda
Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.
Genomics 1998;54(1):39-49.
1998: Shinji Hadano; Y Ishida; Joh-E Ikeda
The primary structure and genomic organization of five novel transcripts located close to the Huntington's disease gene on human chromosome 4p16.3.
DNA research : an international journal for rapid publication of reports on genes and genomes 1998;5(3):177-86.
1998: Q Chen; S D Baird; M Mahadevan; A Besner-Johnston; R Farahani; J Xuan; X Kang; C Lefebvre; Joh-E Ikeda; Robert G Korneluk; Alex E MacKenzie
Sequence of a 131-kb region of 5q13.1 containing the spinal muscular atrophy candidate genes SMN and NAIP.
Genomics 1998;48(1):121-7.
1997: DG Xu; Stephen J Crocker; JP Doucet; Martine St-Jean; K Tamai; Antoine M Hakim; Joh-E Ikeda; Peter Liston; Charlie S Thompson; Robert G Korneluk; Alex Mackenzie; George S Robertson
Elevation of neuronal expression of NAIP reduces ischemic damage in the rat hippocampus.
Nature medicine 1997;3(9):997-1004.
1997: M Kogi; S Fukushige; C Lefevre; Shinji Hadano; Joh-E Ikeda
A novel tandem repeat sequence located on human chromosome 4p: isolation and characterization.
Genomics 1997;42(2):278-83.
1996: Shinji Hadano; Y Ishida; Hitoshi Tomiyasu; K Yamamoto; Gillian P Bates; Joh-E Ikeda
Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus.
DNA research : an international journal for rapid publication of reports on genes and genomes 1996;3(4):239-55.
1996: J D Waring; R Haq; Katsuyuki Tamai; Luc A Sabourin; Joh-E Ikeda; Robert G Korneluk
Investigation of myotonic dystrophy kinase isoform translocation and membrane association.
The Journal of biological chemistry 1996;271(25):15187-93.
1996: S Fukushige; Joh-E Ikeda
Trapping of mammalian promoters by Cre-lox site-specific recombination.
DNA research : an international journal for rapid publication of reports on genes and genomes 1996;3(2):73-80.
1996: Peter Liston; N Roy; Katsuyuki Tamai; C Lefebvre; S Baird; G Cherton-Horvat; R Farahani; M McLean; Joh-E Ikeda; Alex Mackenzie; Robert G Korneluk
Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes.
Nature 1996;379(6563):349-53.
1996: E Rajcan-Separovic; M S Mahadevan; C Lefebvre; A Besner-Johnston; Joh-E Ikeda; Robert G Korneluk; Alex Mackenzie
FISH detection of chromosome polymorphism and deletions in the spinal muscular atrophy (SMA) region of 5q13.
Cytogenetics and cell genetics 1996;75(4):243-7.
1995: Z Yaraghi; M D McLean; N Roy; LC Surh; Joh-E Ikeda; Robert G Korneluk; Alex Mackenzie
A recombination event occurring within two complex 5q13.1 microsatellite repeat polymorphisms suggests a telomeric mapping of spinal muscular atrophy.
Human genetics 1995;96(3):330-4.
1995: E Rajcan-Separovic; H S Wang; Marsha Speevak; L Janes; Robert G Korneluk; K Wakasa; Joh-E Ikeda
Identification of the origin of double minutes in normal human cells by laser-based chromosome microdissection approach.
Human genetics 1995;96(1):39-43.
1995: E J Whiting; J D Waring; Katsuyuki Tamai; M J Somerville; Maxwell T Hincke; W A Staines; Joh-E Ikeda; Robert G Korneluk
Characterization of myotonic dystrophy kinase (DMK) protein in human and rodent muscle and central nervous tissue.
Human molecular genetics 1995;4(6):1063-72.
1995: N Roy; M D McLean; A Besner-Johnston; C Lefebvre; M Salih; J D Carpten; Arthur H M Burghes; Z Yaraghi; Joh-E Ikeda; Robert G Korneluk
Refined physical map of the spinal muscular atrophy gene (SMA) region at 5q13 based on YAC and cosmid contiguous arrays.
Genomics 1995;26(3):451-60.
1994: Z Yaraghi; X Kang; Joh-E Ikeda; Alex Mackenzie
Dinucleotide repeat polymorphism at the human PDGF RB gene.
Human molecular genetics 1994;3(11):2082.
1994: M D McLean; N Roy; Alex E MacKenzie; M Salih; Arthur H M Burghes; Louise R Simard; Robert G Korneluk; Joh-E Ikeda; LC Surh
Two 5q13 simple tandem repeat loci are in linkage disequilibrium with type 1 spinal muscular atrophy.
Human molecular genetics 1994;3(11):1951-6.
1994: Arthur H M Burghes; S E Ingraham; M McLean; T G Thompson; J D McPherson; Z Kote-Jarai; J D Carpten; CJ DiDonato; Joh-E Ikeda; LC Surh
A multicopy dinucleotide marker that maps close to the spinal muscular atrophy gene.
Genomics 1994;21(2):394-402.
1994: H Yokoi; Shinji Hadano; M Kogi; X Kang; K Wakasa; Joh-E Ikeda
Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection.
Genomics 1994;20(3):404-11.
1993: Shinji Hadano; Joh-E Ikeda
[Laser chromosome microdissection and cloning of the genetic disease loci].
Nihon rinsho. Japanese journal of clinical medicine 1993;51(9):2240-5.
1991: Shinji Hadano; M Watanabe; H Yokoi; M Kogi; I Kondo; H Tsuchiya; I Kanazawa; K Wakasa; Joh-E Ikeda
Laser microdissection and single unique primer PCR allow generation of regional chromosome DNA clones from a single human chromosome.
Genomics 1991;11(2):364-73.