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Kiyoshi Ikeda
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39
Inoue, Seiji
20
Fujii, Shinobu
20
Hayashi, Ken'ichiro
15
Samejima, Yuji
11
Katsumura, Shigeo
9
Ohkura, N
9
Iwama, Seiji
8
Hayashi, Kyozo
7
Ishida, Toshimasa
7
Okumura, Kohji
7
Tomoo, Koji
6
Ikezawa, Hiroh
5
Ohishi, Hirofumi
4
Tsukamoto, Kikuo
3
Toyomoto, Misao
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Geonetwork of Kiyoshi Ikeda (preview)
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All Publications
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2009: Shirai Ryoichi; Toriba Michihisa; Hayashi Kyozo; Ikeda Kiyoshi; Inoue Seiji
Identification and characterization of phospholipase A2 inhibitors from the serum of the Japanese rat snake, Elaphe climacophora.
Toxicon : official journal of the International Society on Toxinology 2009;53(6):685-92.
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2009: Shirai Ryoichi; Hirano Fumiyasu; Ohkura Naoki; Ikeda Kiyoshi; Inoue Seiji
Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response.
Biochemical and biophysical research communications 2009;382(4):776-9.
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2008: Shimada Akiko; Ohkura Naoki; Hayashi Kyozo; Samejima Yuji; Omori-Satoh Tamotsu; Inoue Seiji; Ikeda Kiyoshi
Subunit structure and inhibition specificity of alpha-type phospholipase A2 inhibitor from Protobothrops flavoviridis.
Toxicon : official journal of the International Society on Toxinology 2008;51(5):787-96.
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2007: Furukawa Atsushi; Kita Kouzou; Toyomoto Misao; Fujii Shinobu; Inoue Seiji; Hayashi Kyozo; Ikeda Kiyoshi
Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds.
Molecular and cellular biochemistry 2007;305(1-2):27-34.
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2005: Okumura Kohji; Ohno Ai; Nishida Masanori; Hayashi Kyozo; Ikeda Kiyoshi; Inoue Seiji
Mapping the region of the alpha-type phospholipase A2 inhibitor responsible for its inhibitory activity.
The Journal of biological chemistry 2005;280(45):37651-9.
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2005: Toyomoto Misao; Inoue Seiji; Ohta Kiyoe; Kuno Sadako; Ohta Mitsuhiro; Hayashi Kyozo; Ikeda Kiyoshi
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil.
Neuroscience letters 2005;379(3):185-9.
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2005: Hakogi Toshikazu; Fujii Shinobu; Morita Michio; Ikeda Kiyoshi; Katsumura Shigeo
Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase.
Bioorganic & medicinal chemistry letters 2005;15(8):2141-4.
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2005: Fujii Shinobu; Itoh Hiromi; Yoshida Ayumi; Higashi Satoko; Ikezawa Hiroh; Ikeda Kiyoshi
Activation of sphingomyelinase from Bacillus cereus by Zn2+ hitherto accepted as a strong inhibitor.
Archives of biochemistry and biophysics 2005;436(2):227-36.
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2004: Fujii Shinobu; Yoshida Ayumi; Sakurai Saori; Morita Michio; Tsukamoto Kikuo; Ikezawa Hiroho; Ikeda Kiyoshi
Chromogenic assay for the activity of sphingomyelinase from Bacillus cereus and its application to the enzymatic hydrolysis of lysophospholipids.
Biological & pharmaceutical bulletin 2004;27(11):1725-9.
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2004: Fujii Shinobu; Nagata Michiyo; Morita Michio; Minoura Katsuhiko; Tsukamoto Kikuo; Ikezawa Hiroh; Ikeda Kiyoshi
Novel inhibition mechanism of Bacillus cereus sphingomyelinase by beryllium fluoride.
Archives of biochemistry and biophysics 2004;424(2):201-9.
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2004: Toyomoto Misao; Ohta Mitsuhiro; Okumura Kohji; Yano Hiroe; Matsumoto Kaori; Inoue Seiji; Hayashi Kyozo; Ikeda Kiyoshi
Prostaglandins are powerful inducers of NGF and BDNF production in mouse astrocyte cultures.
FEBS letters 2004;562(1-3):211-5.
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2003: Okumura Kohji; Inoue Seiji; Ikeda Kiyoshi; Hayashi Kyozo
Identification and characterization of a serum protein homologous to alpha-type phospholipase A2 inhibitor (PLIalpha) from a nonvenomous snake, Elaphe quadrivirgata.
IUBMB life 2003;55(9):539-45.
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2002: Okumura Kohji; Inoue Seiji; Ikeda Kiyoshi; Hayashi Kyozo
Identification of beta-type phospholipase A(2) inhibitor in a nonvenomous snake, Elaphe quadrivirgata.
Archives of biochemistry and biophysics 2002;408(1):124-30.
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2002: Hakogi Toshikazu; Monden Yoshiko; Taichi Misako; Iwama Seiji; Fujii Shinobu; Ikeda Kiyoshi; Katsumura Shigeo
Synthesis of sphingomyelin carbon analogues as sphingomyelinase inhibitors.
The Journal of organic chemistry 2002;67(14):4839-46.
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2001: Inoue S; Ikeda K
[Three families of phospholipase A2 inhibitory proteins derived from the blood of venomous snakes]
Seikagaku. The Journal of Japanese Biochemical Society 2001;73(2):92-6.
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1999: Okumura K; Inoue S; Ikeda K; Hayashi K
cDNA cloning and bacterial expression of phospholipase A(2) inhibitor PLIalpha from the serum of the Chinese mamushi, Agkistrodon blomhoffii siniticus(1).
Biochimica et biophysica acta 1999;1441(1):51-60.
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1999: Okumura K; Inoue S; Ohkura N; Ikeda K; Hayashi K
cDNA cloning of the two subunits of phospholipase A2 inhibitor PLIgamma from blood plasma of the Chinese mamushi, Agkistrodon blomhoffii siniticus.
IUBMB life 1999;48(1):99-104.
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1999: Fujii S; Ogata K; Inoue B; Inoue S; Murakami M; Iwama S; Katsumura S; Tomita M; Tamura H; Tsukamoto K; Ikezawa H; Ikeda K
Roles of asp126 and asp156 in the enzyme function of sphingomyelinase from Bacillus cereus.
Journal of biochemistry 1999;126(1):90-7.
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1999: Okumura K; Masui K; Inoue S; Ikeda K; Hayashi K
Purification, characterization and cDNA cloning of a phospholipase A2 inhibitor from the serum of the non-venomous snake Elaphe quadrivirgata.
The Biochemical journal 1999;341 ( Pt 1)():165-71.
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1999: Ohkura N; Kitahara Y; Inoue S; Ikeda K; Hayashi K
Isolation and amino acid sequence of a phospholipase A2 inhibitor from the blood plasma of the sea krait, Laticauda semifasciata.
Journal of biochemistry 1999;125(2):375-82.
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1998: Iwama S; Segawa M; Fujii S; Ikeda K; Katsumura S
Design and synthesis of new secretory phospholipase A2 inhibitor of a phospholipid analog.
Bioorganic & medicinal chemistry letters 1998;8(24):3495-8.
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1998: Fujii S; Inoue B; Yamamoto H; Ogata K; Shinki T; Inoue S; Tomita M; Tamura H; Tsukamoto K; Ikezawa H; Ikeda K
Mg2+ binding and catalytic function of sphingomyelinase from Bacillus cereus.
Journal of biochemistry 1998;124(6):1178-87.
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1998: Okumura K; Ohkura N; Inoue S; Ikeda K; Hayashi K
A novel phospholipase A2 inhibitor with leucine-rich repeats from the blood plasma of Agkistrodon blomhoffii siniticus. Sequence homologies with human leucine-rich alpha2-glycoprotein.
The Journal of biological chemistry 1998;273(31):19469-75.
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1998: Fujii S; Meida M; Tani T; Inoue S; Iwama S; Katsumura S; Ikeda K
pH dependence of the reaction rate of p-bromophenacyl bromide and of the binding constants of Ca2+ and an amide-type substrate analog to bovine pancreatic phospholipase A2.
Archives of biochemistry and biophysics 1998;354(1):73-82.
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1997: Tomoo K; Yamane A; Ishida T; Fujii S; Ikeda K; Iwama S; Katsumura S; Sumiya S; Miyagawa H; Kitamura K
X-ray crystal structure determination and molecular dynamics simulation of prophospholipase A2 inhibited by amide-type substrate analogues.
Biochimica et biophysica acta 1997;1340(2):178-86.
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1997: Ohkura N; Okuhara H; Inoue S; Ikeda K; Hayashi K
Purification and characterization of three distinct types of phospholipase A2 inhibitors from the blood plasma of the Chinese mamushi, Agkistrodon blomhoffii siniticus.
The Biochemical journal 1997;325 ( Pt 2)():527-31.
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1997: Inoue S; Shimada A; Ohkura N; Ikeda K; Samejima Y; Omori-Satoh T; Hayashi K
Specificity of two types of phospholipase A2 inhibitors from the plasma of venomous snakes.
Biochemistry and molecular biology international 1997;41(3):529-37.
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1995: Iwama S; Matsuda T; Katsumura S; Tani T; Fujii S; Ikeda K; Takehara H
New phospholipase A2 inhibitor: synthesis and inhibition mechanism of oxazolidinone phospholipid analog.
Bioorganic & medicinal chemistry 1995;3(10):1397-403.
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1995: Fujii S; Tahara Y; Toyomoto M; Hada S; Nishimura H; Inoue S; Ikeda K; Inagaki Y; Katsumura S; Samejima Y
Chemical modification and inactivation of phospholipases A2 by a manoalide analogue.
The Biochemical journal 1995;308 ( Pt 1)():297-304.
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1995: Tani T; Fujii S; Inoue S; Ikeda K; Iwama S; Matsuda T; Katsumura S; Samejima Y; Hayashi K
Binding mode of phospholipase A2 with a new type of phospholipid analog having an oxazolidinone ring.
Journal of biochemistry 1995;117(1):176-82.
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1994: Ohkura N; Inoue S; Ikeda K; Hayashi K
The two subunits of a phospholipase A2 inhibitor from the plasma of Thailand cobra having structural similarity to urokinase-type plasminogen activator receptor and LY-6 related proteins.
Biochemical and biophysical research communications 1994;204(3):1212-8.
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1994: Fujii S; Tani T; Hada S; Inoue S; Ikeda K; Iwama S; Katsumura S; Samejima Y; Omori-Satoh T; Takasaki C
Role of Ca2+ in the binding of phospholipase A2 with a monomeric substrate and with its amide-type analog.
Journal of biochemistry 1994;116(4):870-6.
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1994: Tomoo K; Ohishi H; Ishida T; Inoue M; Ikeda K; Sumiya S; Kitamura K
X-ray crystal structure and molecular dynamics simulation of bovine pancreas phospholipase A2-n-dodecylphosphorylcholine complex.
Proteins 1994;19(4):330-9.
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1994: Ohkura N; Inoue S; Ikeda K; Hayashi K
Isolation and characterization of a phospholipase A2 inhibitor from the blood plasma of the Thailand cobra Naja naja kaouthia.
Biochemical and biophysical research communications 1994;200(2):784-8.
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1993: Ohishi H; Fujii S; Tomoo K; Ishida T; Ikeda K; Tanabe K; Kitamura K
Molecular dynamics simulation of 1,2-dilauroyl-L-phosphatidylethanolamine binding to phospholipase A2: an attempt to explain the selective hydrolysis of substrate fatty acid ester at position 2.
Journal of biochemistry 1993;114(2):210-4.
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1993: Ohkura N; Inoue S; Ikeda K; Hayashi K
Isolation and amino acid sequence of a phospholipase A2 inhibitor from the blood plasma of Agkistrodon blomhoffii siniticus.
Journal of biochemistry 1993;113(4):413-9.
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1993: Tomoo K; Fujii S; Ishida T; Inoue M; Ikeda K; Samejima Y; Iwama S; Katsumura S
Crystallization and preliminary X-ray study of Agkistrodon halys blomhoffii phospholipase A2 complexed with a specific inhibitor.
Journal of biochemistry 1993;113(4):411-2.
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1993: Hada S; Fujii S; Inoue S; Ikeda K; Teshima K
Hydrolysis of micellar diheptanoylphosphatidylcholine catalyzed by bovine pancreatic phospholipase A2: kinetic characterization of group I and II enzymes.
Journal of biochemistry 1993;113(1):13-8.
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1992: Koyama J; Inoue S; Ikeda K; Hayashi K
Purification and amino-acid sequence of a nerve growth factor from the venom of Vipera russelli russelli.
Biochimica et biophysica acta 1992;1160(3):287-92.
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1992: Tomoo K; Ohishi H; Doi M; Ishida T; Inoue M; Ikeda K; Mizuno H
Interaction mode of n-dodecylphosphorylcholine, a substrate analogue, with bovine pancreas phospholipase A2 as determined by X-ray crystal analysis.
Biochemical and biophysical research communications 1992;187(2):821-7.
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1992: Tomoo K; Ohishi H; Doi M; Ishida T; Inoue M; Ikeda K; Hata Y; Samejima Y
Structure of acidic phospholipase A2 for the venom of Agkistrodon halys blomhoffii at 2.8 A resolution.
Biochemical and biophysical research communications 1992;184(1):137-43.
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1992: Nishimura H; Inoue S; Ikeda K; Teshima K; Samejima Y; Omori-Satoh T; Hayashi K
Kinetics of the hydrolysis of micellar substrates catalyzed by snake venom phospholipases A2.
Journal of biochemistry 1992;111(2):210-8.
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1991: Fujii S; Inoue T; Inoue S; Ikeda K
Kinetics of the hydrolysis of monodispersed dihexanoylphosphatidylcholine catalyzed by bovine pancreatic phospholipase A2: roles of Ca2+ binding and ionizations of amino acid residues in the active site.
Journal of biochemistry 1991;110(6):1008-15.
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1991: Ikeda K; Inoue S; Amasaki C; Teshima K; Ikezawa H
Kinetics of the hydrolysis of monodispersed and micellar phosphatidylcholines catalyzed by a phospholipase C from Bacillus cereus.
Journal of biochemistry 1991;110(1):88-95.
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1991: Inoue S; Oda T; Koyama J; Ikeda K; Hayashi K
Amino acid sequences of nerve growth factors derived from cobra venoms.
FEBS letters 1991;279(1):38-40.
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1991: Inoue S; Kogaki H; Ikeda K; Samejima Y; Omori-Satoh T
Amino acid sequences of the two subunits of a phospholipase A2 inhibitor from the blood plasma of Trimeresurus flavoviridis. Sequence homologies with pulmonary surfactant apoprotein and animal lectins.
The Journal of biological chemistry 1991;266(2):1001-7.
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1990: Teshima K; Samejima Y; Kawauchi S; Ikeda K
Kinetics of the hydrolysis of mixed micelles of dipalmitoyllecithin with triton X-100 catalyzed by a phospholipase A2 from the venom of Agkistrodon halys blomhoffii.
Journal of biochemistry 1990;108(1):21-7.
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1989: Kogaki H; Inoue S; Ikeda K; Samejima Y; Omori-Satoh T; Hamaguchi K
Isolation and fundamental properties of a phospholipase A2 inhibitor from the blood plasma of Trimeresurus flavoviridis.
Journal of biochemistry 1989;106(6):966-71.
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1989: Inoue S; Okumura K; Tsujino M; Ohkura K; Ikeda K; Takechi M; Tanaka Y; Hayashi K
Amino acid sequences of cytotoxin-like basic proteins derived from cobra venoms.
FEBS letters 1989;257(2):319-23.
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1989: Oda T; Ohta M; Inoue S; Ikeda K; Furukawa S; Hayashi K
Amino acid sequence of nerve growth factor purified from the venom of the Formosan cobra Naja naja atra.
Biochemistry international 1989;19(4):909-17.
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1989: Teshima K; Kitagawa Y; Samejima Y; Kawauchi S; Fujii S; Ikeda K; Hayashi K; Omori-Satoh T
Role of Ca2+ in the substrate binding and catalytic functions of snake venom phospholipases A2.
Journal of biochemistry 1989;106(3):518-27.
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1989: Teshima K; Ikeda K; Miyake T; Imamura M; Inoue S; Samejima Y; Kawauchi S; Omori-Satoh T
Interactions of monodispersed and micellar substrates with a phospholipase A2 from Trimeresurus flavoviridis.
Journal of biochemistry 1989;105(6):1044-51.
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1989: Miyake T; Inoue S; Ikeda K; Teshima K; Samejima Y; Omori-Satoh T
pH dependence of the reaction rate of His 48 with p-bromophenacyl bromide and of the binding constant to Ca2+ of the monomeric forms of intact and alpha-NH2 modified phospholipases A2 from Trimeresurus flavoviridis.
Journal of biochemistry 1989;105(4):565-72.
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1989: Tomoo K; Ohishi H; Ishida T; Inoue M; Ikeda K; Aoki Y; Samejima Y
Revised amino acid sequence, crystallization, and preliminary x-ray diffraction analysis of acidic phospholipase A2 from the venom of Agkistrodon halys blomhoffii.
The Journal of biological chemistry 1989;264(6):3636-8.
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1988: Ohkura K; Inoue S; Ikeda K; Hayashi K
Amino-acid sequences of four cytotoxins (cytotoxins I, II, III and IV) purified from the venom of the Thailand cobra, Naja naja siamensis.
Biochimica et biophysica acta 1988;954(2):148-53.
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1986: Teshima K; Kitagawa Y; Samejima Y; Kawauchi S; Ikeda K
Kinetics of the hydrolysis of monodispersed dihexanoyllecithin catalyzed by the phospholipase A2 from Agkistrodon halys blomhoffii venom.
Journal of biochemistry 1986;100(6):1655-62.
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1986: Haruki H; Teshima K; Samejima Y; Kawauchi S; Ikeda K
Interaction of monodispersed and micellar phospholipids with an Agkistrodon halys blomhoffii phospholipase A2, in which the alpha-amino group had been modified to an alpha-keto group.
Journal of biochemistry 1986;99(1):99-109.
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1985: Teshima K; Samejima Y; Kawauchi S; Ikeda K; Hayashi K
Kinetics of the hydrolysis of monodispersed dihexanoyllecithin catalyzed by a cobra (Naja naja atra) venom phospholipase A2.
Journal of biochemistry 1985;98(6):1509-17.
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1984: Teshima K; Samejima Y; Kawauchi S; Ikeda K; Hayashi K
Bindings of Ca2+ and substrate analogs to a cobra venom phospholipase A2 in which the alpha-amino group is modified to an alpha-keto group.
Journal of biochemistry 1984;96(6):1903-13.
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