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Yoshitaka Ikeda

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Daisuke Osumi; Motoko Takahashi; Eiji Miyoshi; Shunichi Yokoe; Seung Ho Lee; Katsuhisa Noda; Shoji Nakamori; Jianguo Gu; Yoshitaka Ikeda; Yoshio Kuroki; Kazuo Sengoku; M Ishikawa; Naoyuki Taniguchi
Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.
Wei Li; Motoko Takahashi; Yukinao Shibukawa; Shunichi Yokoe; Jianguo Gu; Eiji Miyoshi; Koichi Honke; Yoshitaka Ikeda; Naoyuki Taniguchi
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.
Hideyuki Ihara; Yoshitaka Ikeda; Sachiko Toma; Wang Xiangchun; Tadashi Suzuki; Jianguo Gu; Eiji Miyoshi; Tomitake Tsukihara; Koichi Honke; Akio Matsumoto; Atsushi Nakagawa; Naoyuki Taniguchi
Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.

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All Publications

2009: Daisuke Osumi; Motoko Takahashi; Eiji Miyoshi; Shunichi Yokoe; Seung Ho Lee; Katsuhisa Noda; Shoji Nakamori; Jianguo Gu; Yoshitaka Ikeda; Yoshio Kuroki; Kazuo Sengoku; M Ishikawa; Naoyuki Taniguchi
Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells.
Cancer science 2009;100(5):888-95.
2007: Wei Li; Motoko Takahashi; Yukinao Shibukawa; Shunichi Yokoe; Jianguo Gu; Eiji Miyoshi; Koichi Honke; Yoshitaka Ikeda; Naoyuki Taniguchi
Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances its activity.
Glycobiology 2007;17(6):655-62.
2007: Hideyuki Ihara; Yoshitaka Ikeda; Sachiko Toma; Wang Xiangchun; Tadashi Suzuki; Jianguo Gu; Eiji Miyoshi; Tomitake Tsukihara; Koichi Honke; Akio Matsumoto; Atsushi Nakagawa; Naoyuki Taniguchi
Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8.
Glycobiology 2007;17(5):455-66.
2006: Hideyuki Ihara; Yoshitaka Ikeda; Naoyuki Taniguchi
Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8.
Glycobiology 2006;16(4):333-42.
2005: Wang Xiangchun; Shinya Inoue; Jianguo Gu; Eiji Miyoshi; Katsuhisa Noda; Wenzhe Li; Yoko Mizuno-Horikawa; Miyako Nakano; Michio Asahi; Motoko Takahashi; Naofumi Uozumi; Shinji Ihara; Seung Ho Lee; Yoshitaka Ikeda; Yukihiro Yamaguchi; Yoshiya Aze; Yoshiaki Tomiyama; Junichi Fujii; Keiichiro Suzuki; Akihiro Kondo; Steven D Shapiro; Carlos Lopez-Otin; Tomoyuki Kuwaki; Masaru Okabe; Koichi Honke; Naoyuki Taniguchi
Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(44):15791-6.
2005: Hironobu Eguchi; Yoshitaka Ikeda; Tomomi Ookawara; Souichi Koyota; Noriko Fujiwara; Koichi Honke; Peng George Wang; Naoyuki Taniguchi; Keiichiro Suzuki
Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis x-mediated cell adhesion.
Glycobiology 2005;15(11):1094-101.
2004: Jianguo Gu; Yanyang Zhao; Tomoya Isaji; Yukinao Shibukawa; Hideyuki Ihara; Motoko Takahashi; Yoshitaka Ikeda; Eiji Miyoshi; Koichi Honke; Naoyuki Taniguchi
Beta1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.
Glycobiology 2004;14(2):177-86.
2003: Ken Sasai; Yoshitaka Ikeda; Hideyuki Ihara; Koichi Honke; Naoyuki Taniguchi
Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus.
The Journal of biological chemistry 2003;278(28):25295-301.
2002: Tomomi Ookawara; Takako Kizaki; Eiji Takayama; Nobuo Imazeki; Osamu Matsubara; Yoshitaka Ikeda; Keiichiro Suzuki; Li Li Ji; Takushi Tadakuma; Naoyuki Taniguchi; Hideki Ohno
Nuclear translocation of extracellular superoxide dismutase.
Biochemical and biophysical research communications 2002;296(1):54-61.
2002: Ken Sasai; Yoshitaka Ikeda; Hironobu Eguchi; Takeo Tsuda; Koichi Honke; Naoyuki Taniguchi
The action of N-acetylglucosaminyltransferase-V is prevented by the bisecting GlcNAc residue at the catalytic step.
FEBS letters 2002;522(1-3):151-5.
2002: Hironobu Eguchi; Yoshitaka Ikeda; Souichi Koyota; Koichi Honke; Keiichiro Suzuki; John M C Gutteridge; Naoyuki Taniguchi
Oxidative damage due to copper ion and hydrogen peroxide induces GlcNAc-specific cleavage of an Asn-linked oligosaccharide.
Journal of biochemistry 2002;131(3):477-84.
2002: Ken Sasai; Yoshitaka Ikeda; Tsuneko Fujii; Takeo Tsuda; Naoyuki Taniguchi
UDP-GlcNAc concentration is an important factor in the biosynthesis of beta1,6-branched oligosaccharides: regulation based on the kinetic properties of N-acetylglucosaminyltransferase V.
Glycobiology 2002;12(2):119-27.
2002: Hideyuki Ihara; Yoshitaka Ikeda; Souichi Koyota; Takeshi Endo; Koichi Honke; Naoyuki Taniguchi
A catalytically inactive beta 1,4-N-acetylglucosaminyltransferase III (GnT-III) behaves as a dominant negative GnT-III inhibitor.
European journal of biochemistry / FEBS 2002;269(1):193-201.
2001: Naoyuki Taniguchi; Shinji Ihara; Takashi Saito; Eiji Miyoshi; Yoshitaka Ikeda; Koichi Honke
Implication of GnT-V in cancer metastasis: a glycomic approach for identification of a target protein and its unique function as an angiogenic cofactor.
Glycoconjugate journal 2001;18(11-12):859-65.
2001: Souichi Koyota; Yoshitaka Ikeda; Shuji Miyagawa; Hideyuki Ihara; Masaru Koma; Koichi Honke; Ryota Shirakura; Naoyuki Taniguchi
Down-regulation of the alpha-Gal epitope expression in N-glycans of swine endothelial cells by transfection with the N-acetylglucosaminyltransferase III gene. Modulation of the biosynthesis of terminal structures by a bisecting GlcNAc.
The Journal of biological chemistry 2001;276(35):32867-74.
2001: Naoyuki Taniguchi; Atsuko Ekuni; Jeong Heon Ko; Eiji Miyoshi; Yoshitaka Ikeda; Y Ihara; A Nishikawa; Koichi Honke; Masahiko Takahashi
A glycomic approach to the identification and characterization of glycoprotein function in cells transfected with glycosyltransferase genes.
Proteomics 2001;1(2):239-47.
2001: W Wang; Wenzhe Li; Yoshitaka Ikeda; J I Miyagawa; M Taniguchi; Eiji Miyoshi; Y Sheng; Atsuko Ekuni; Jeong Heon Ko; Y Yamamoto; T Sugimoto; S Yamashita; Y Matsuzawa; G A Grabowski; Koichi Honke; Naoyuki Taniguchi
Ectopic expression of alpha1,6 fucosyltransferase in mice causes steatosis in the liver and kidney accompanied by a modification of lysosomal acid lipase.
Glycobiology 2001;11(2):165-74.
2001: Ken Sasai; Yoshitaka Ikeda; Takeo Tsuda; Hideyuki Ihara; Hiroaki Korekane; K Shiota; Naoyuki Taniguchi
The critical role of the stem region as a functional domain responsible for the oligomerization and Golgi localization of N-acetylglucosaminyltransferase V. The involvement of a domain homophilic interaction.
The Journal of biological chemistry 2001;276(1):759-65.
2000: T Takahashi; Yoshitaka Ikeda; Eiji Miyoshi; Y Yaginuma; M Ishikawa; Naoyuki Taniguchi
alpha1,6fucosyltransferase is highly and specifically expressed in human ovarian serous adenocarcinomas.
International journal of cancer. Journal international du cancer 2000;88(6):914-9.
2000: A Murase; Shuji Miyagawa; Masaru Koma; Yoshitaka Ikeda; Koichi Honke; Nobutaka Wakamiya; S Tuji; Ryota Shirakura; Naoyuki Taniguchi
An attempt to downregulate the Hanganutziu-Deicher antigen by overexpression of glycosyltransferases.
Transplantation proceedings 2000;32(7):2507-8.
2000: C X Gao-Uozumi; Naofumi Uozumi; Eiji Miyoshi; K Nagai; Yoshitaka Ikeda; T Teshima; Katsuhisa Noda; T Shiba; Koichi Honke; Naoyuki Taniguchi
A novel carbohydrate binding activity of annexin V toward a bisecting N-acetylglucosamine.
Glycobiology 2000;10(11):1209-16.
2000: Yoshitaka Ikeda; Souichi Koyota; Hideyuki Ihara; Y Yamaguchi; Hiroaki Korekane; Takeo Tsuda; Ken Sasai; Naoyuki Taniguchi
Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III.
Journal of biochemistry 2000;128(4):609-19.
2000: Masaru Koma; Shuji Miyagawa; Koichi Honke; Yoshitaka Ikeda; Souichi Koyota; A Murase; Shingo Tsuji; Shinichirou Miyoshi; Hikaru Matsuda; Ryota Shirakura; Naoyuki Taniguchi
Effect of various glycosyltransferases on the swine xenoantigen.
Transplantation proceedings 2000;32(5):855.
2000: Takeo Tsuda; Yoshitaka Ikeda; Naoyuki Taniguchi
The Asn-420-linked sugar chain in human epidermal growth factor receptor suppresses ligand-independent spontaneous oligomerization. Possible role of a specific sugar chain in controllable receptor activation.
The Journal of biological chemistry 2000;275(29):21988-94.
2000: Masaru Koma; Shuji Miyagawa; Koichi Honke; Yoshitaka Ikeda; Souichi Koyota; Shinichirou Miyoshi; Hikaru Matsuda; Shingo Tsuji; Ryota Shirakura; Naoyuki Taniguchi
Reduction of the major xenoantigen on glycosphingolipids of swine endothelial cells by various glycosyltransferases.
Glycobiology 2000;10(7):745-51.
2000: Yuji Yamaguchi; Yoshitaka Ikeda; T Takahashi; Hideyuki Ihara; T Tanaka; C Sasho; Naofumi Uozumi; Shusaku Yanagidani; Seiji Inoue; Junichi Fujii; Naoyuki Taniguchi
Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8).
Glycobiology 2000;10(6):637-43.
2000: T Takahashi; Yoshitaka Ikeda; A Tateishi; Yuji Yamaguchi; M Ishikawa; Naoyuki Taniguchi
A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues.
Glycobiology 2000;10(5):503-10.
2000: R Kang; Yoshitaka Ikeda; Eiji Miyoshi; W Wang; Wei Li; Y Ihara; Y Sheng; Naoyuki Taniguchi
Cell cycle-dependent regulation of N-acetylglucosaminyltransferase-III in a human colon cancer cell line, Colo201.
Archives of biochemistry and biophysics 2000;374(1):52-8.
1999: Eiji Miyoshi; Katsuhisa Noda; Yuji Yamaguchi; Seiji Inoue; Yoshitaka Ikeda; W Wang; Jeong Heon Ko; Naofumi Uozumi; Wenzhe Li; Naoyuki Taniguchi
The alpha1-6-fucosyltransferase gene and its biological significance.
Biochimica et biophysica acta 1999;1473(1):9-20.
1999: Shuji Miyagawa; Rie Nakai; Masashi Yamada; Masahiro Tanemura; Yoshitaka Ikeda; Naoyuki Taniguchi; Ryota Shirakura
Regulation of natural killer cell-mediated swine endothelial cell lysis through genetic remodeling of a glycoantigen.
Journal of biochemistry 1999;126(6):1067-73.
1999: Shuji Miyagawa; Masahiro Tanemura; Souichi Koyota; Masaru Koma; Yoshitaka Ikeda; Ryota Shirakura; Naoyuki Taniguchi
Masking and reduction of the Galactose-alpha1,3-Galactose (alpha-Gal) epitope, the major xenoantigen in swine, by the glycosyltransferase gene transfection.
Biochemical and biophysical research communications 1999;264(3):611-4.
1999: Naoyuki Taniguchi; Eiji Miyoshi; Jeong Heon Ko; Yoshitaka Ikeda; Y Ihara
Implication of N-acetylglucosaminyltransferases III and V in cancer: gene regulation and signaling mechanism.
Biochimica et biophysica acta 1999;1455(2-3):287-300.
1999: Jeong Heon Ko; Eiji Miyoshi; Katsuhisa Noda; Atsuko Ekuni; R Kang; Yoshitaka Ikeda; Naoyuki Taniguchi
Regulation of the GnT-V promoter by transcription factor Ets-1 in various cancer cell lines.
The Journal of biological chemistry 1999;274(33):22941-8.
1999: Eiji Miyoshi; Katsuhisa Noda; Jeong Heon Ko; Atsuko Ekuni; Takatoshi Kitada; Naofumi Uozumi; Yoshitaka Ikeda; Nariaki Matsuura; Yutaka Sasaki; Norio Hayashi; Masatsugu Hori; Naoyuki Taniguchi
Overexpression of alpha1-6 fucosyltransferase in hepatoma cells suppresses intrahepatic metastasis after splenic injection in athymic mice.
Cancer research 1999;59(9):2237-43.
1999: Yuji Yamaguchi; Junichi Fujii; Seiji Inoue; Naofumi Uozumi; Shusaku Yanagidani; Yoshitaka Ikeda; M Egashira; O Miyoshi; Norio Niikawa; Naoyuki Taniguchi
Mapping of the alpha-1,6-fucosyltransferase gene, FUT8, to human chromosome 14q24.3.
Cytogenetics and cell genetics 1999;84(1-2):58-60.
1998: Katsuhisa Noda; Eiji Miyoshi; Naofumi Uozumi; Shusaku Yanagidani; Yoshitaka Ikeda; C Gao; Keiichiro Suzuki; Harumasa Yoshihara; Kiyoshi Yoshikawa; Kiyoshi Kawano; Norio Hayashi; Masatsugu Hori; Naoyuki Taniguchi; M Yoshikawa
Gene expression of alpha1-6 fucosyltransferase in human hepatoma tissues: a possible implication for increased fucosylation of alpha-fetoprotein.
Hepatology (Baltimore, Md.) 1998;28(4):944-52.
1998: Junichi Fujii; Yoshitaka Ikeda; Takeshi Watanabe; Y Kawasaki; Keiichiro Suzuki; C Fujii; Masahiko Takahashi; Naoyuki Taniguchi
A defect in the mitochondrial import of mutant Mn-superoxide dismutase produced in Sf21 cells.
Journal of biochemistry 1998;124(2):340-6.
1998: Naoyuki Taniguchi; M Yoshimura; Eiji Miyoshi; Y Ihara; A Nishikawa; R Kang; Yoshitaka Ikeda
Gene expression and regulation of N-acetylglucosaminyltransferases III and V in cancer tissues.
Advances in enzyme regulation 1998;38():223-32.
1998: Naoyuki Taniguchi; Yoshitaka Ikeda
gamma-Glutamyl transpeptidase: catalytic mechanism and gene expression.
Advances in enzymology and related areas of molecular biology 1998;72():239-78.
1997: Shin-ichi Iwamoto; Tomio Kawasaki; Junichi Kambayashi; Hideo Ariyoshi; N Shinoki; Masato Sakon; Yoshitaka Ikeda; Morito Monden
The release mechanism of platelet-activating factor during shear-stress induced platelet aggregation.
Biochemical and biophysical research communications 1997;239(1):101-5.
1996: Yoshitaka Ikeda; Junichi Fujii; Naoyuki Taniguchi
Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase.
Journal of biochemistry 1996;119(6):1166-70.
1995: Junichi Fujii; T Myint; H G Seo; Y Kayanoki; Yoshitaka Ikeda; Naoyuki Taniguchi
Characterization of wild-type and amyotrophic lateral sclerosis-related mutant Cu,Zn-superoxide dismutases overproduced in baculovirus-infected insect cells.
Journal of neurochemistry 1995;64(4):1456-61.
1994: Yoshitaka Ikeda; T Sugiyama; M Takahashi; Naoyuki Taniguchi
Selective suppression of IgG2a subclass in LEC rats during development.
Biochimica et biophysica acta 1994;1200(3):277-80.
1993: Yoshitaka Ikeda; Junichi Fujii; Naoyuki Taniguchi
Significance of Arg-107 and Glu-108 in the catalytic mechanism of human gamma-glutamyl transpeptidase. Identification by site-directed mutagenesis.
The Journal of biological chemistry 1993;268(6):3980-5.
1991: T Sugiyama; M Matsunaga; S K Jain; S Jain; Yoshitaka Ikeda; Naoyuki Taniguchi
Enhancing effect of a choline-deficient diet on alterations of hepatic drug-metabolizing enzymes in hepatitis- and hepatoma-predisposed rats (LEC rats).
Japanese journal of cancer research : Gann 1991;82(4):390-6.