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Hiroshi Ikegami

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Naru Babaya; Tomomi Fujisawa; Yoshihisa Hiromine; Michiko Itoi-Babaya; Misato Kobayashi; Koji Nojima; Shinsuke Noso; Hironori Ueda; Hiroshi Ikegami
Dose effect and mode of inheritance of diabetogenic gene on mouse chromosome 11.
Koji Nojima; Naru Babaya; Hiroshi Ikegami; Ken Sugimoto; Hironori Ueda; Hiromi Rakugi
Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet.
Yumiko Kawabata; Hiroshi Ikegami
[Diagnosis of type 1 diabetes].

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2013: Naru Babaya; Tomomi Fujisawa; Yoshihisa Hiromine; Michiko Itoi-Babaya; Misato Kobayashi; Koji Nojima; Shinsuke Noso; Hironori Ueda; Hiroshi Ikegami
Dose effect and mode of inheritance of diabetogenic gene on mouse chromosome 11.
Journal of diabetes research 2013;2013():608923.
2013: Koji Nojima; Naru Babaya; Hiroshi Ikegami; Ken Sugimoto; Hironori Ueda; Hiromi Rakugi
Analysis of hepatic gene expression profile in a spontaneous mouse model of type 2 diabetes under a high sucrose diet.
Endocrine journal 2013;60(3):261-74.
2012: Yumiko Kawabata; Hiroshi Ikegami
[Diagnosis of type 1 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():421-5.
2012: Naru Babaya; Hiroshi Ikegami
[Genetic susceptibility to type 1 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2012;70 Suppl 3():337-41.
2011: Masanori Moriguchi; Shinsuke Noso; Yumiko Kawabata; Takaaki Yamauchi; Takeshi Harada; Katsumori Komaki; Naru Babaya; Yoshihisa Hiromine; Hiroyuki Ito; Satomi Yamagata; Kaori Murata; Takahiro Higashimoto; Choongyong Park; Akinobu Yamamoto; Yasuhiro Ohno; Hiroshi Ikegami
Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity.
Metabolism: clinical and experimental 2011;60(6):761-6.
2011: Tomomi Fujisawa; Hiroshi Ikegami; Hiromi Rakugi
[Organs related to glucose metabolism and aging in animal models].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2011;48(2):127-9.
2011: Naoto Hayasaka; Kazuyuki Aoki; Saori Kinoshita; Shoutaroh Yamaguchi; John K Wakefield; Sachiyo Tsuji-Kawahara; Kazumasa Horikawa; Hiroshi Ikegami; Shigeharu Wakana; Takamichi Murakami; Ram Ramabhadran; Masaaki Miyazawa; Shigenobu Shibata
Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown mice.
PloS one 2011;6(3):e17655.
2011: Hiroyuki Ito; Yasuhiro Ohno; Takaaki Yamauchi; Yumiko Kawabata; Hiroshi Ikegami
Efficacy and safety of metformin for treatment of type 2 diabetes in elderly Japanese patients.
Geriatrics & gerontology international 2011;11(1):55-62.
2010: Naru Babaya; Tomomi Fujisawa; Koji Nojima; Michiko Itoi-Babaya; Kaori Yamaji; Kazunori Yamada; Misato Kobayashi; Hironori Ueda; Yoshihisa Hiromine; Shinsuke Noso; Hiroshi Ikegami
Direct evidence for susceptibility genes for type 2 diabetes on mouse chromosomes 11 and 14.
Diabetologia 2010;53(7):1362-71.
2010: Nobuyasu Shindo; Tomomi Fujisawa; Ken Sugimoto; Koji Nojima; Aya Oze-Fukai; Yuki Yoshikawa; Xiang Wang; Osamu Yasuda; Hiroshi Ikegami; Hiromi Rakugi
Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model.
Journal of hepatology 2010;52(6):903-12.
2010: Naoki Oiso; Daisuke Tsuruta; Hisayoshi Imanishi; Haruyo Sayasa; Tomohiko Narita; Hiromi Kobayashi; Hiroshi Ikegami; Akira Kawada
Phylloid hypermelanosis and melanocytic nevi with aggregated and disfigured melanosomes: causal relationship between phylloid pigment distribution and chromosome 13 abnormalities.
Dermatology (Basel, Switzerland) 2010;220(2):169-72.
2009: Yumiko Kawabata; Hiroshi Ikegami; Takuya Awata; A Imagawa; T Maruyama; Eiji Kawasaki; S Tanaka; A Shimada; H Osawa; T Kobayashi; Toshiaki Hanafusa; K Tokunaga; H Makino
Differential association of HLA with three subtypes of type 1 diabetes: fulminant, slowly progressive and acute-onset.
Diabetologia 2009;52(12):2513-21.
2009: Aya Oze-Fukai; Tomomi Fujisawa; Ken Sugimoto; Koji Nojima; Nobuyasu Shindo; Satomi Shimoyoshi; Yuki Yoshikawa; Yoshifumi Sato; Iichiro Shimomura; Hiroshi Ikegami; Hiromi Rakugi
A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease: spontaneous amelioration of diabetes by augmented beta cell mass.
Endocrine journal 2009;56(2):227-34.
2008: Hiroshi Ikegami; Masaya Ono; Tomomi Fujisawa; Yoshihisa Hiromine; Yumiko Kawabata; Eiji Yamato
Molecular scanning of the gene for thioredoxin, an antioxidative and antiapoptotic protein, and genetic susceptibility to type 1 diabetes.
Annals of the New York Academy of Sciences 2008;1150():103-5.
2008: Yoshihisa Hiromine; Tomomi Fujisawa; Shinsuke Noso; Naru Babaya; Yumiko Kawabata; Hiroshi Ikegami
Congenic mapping of the MHC-linked susceptibility to type 1 diabetes in the NOD mouse: at least two genes contribute to the Idd16 effect.
Annals of the New York Academy of Sciences 2008;1150():90-2.
2008: Hiroshi Ikegami; Shinsuke Noso; Naru Babaya; Yoshihisa Hiromine; Yumiko Kawabata
Genetic Basis of Type 1 Diabetes: Similarities and Differences between East and West.
The review of diabetic studies : RDS 2008;5(2):64-72.
2008: Mayu Yamamoto; Eiji Yamato; Shu-Ichi Toyoda; Fumi Tashiro; Hiroshi Ikegami; Junji Yodoi; Jun-Ichi Miyazaki
Transgenic expression of antioxidant protein thioredoxin in pancreatic beta cells prevents progression of type 2 diabetes mellitus.
Antioxidants & redox signaling 2008;10(1):43-9.
2008: Tomomi Fujisawa; Hiroshi Ikegami; Soji Kasayama; Munehide Matsuhisa; Yoshimitsu Yamasaki; Jun-ichiro Miyagawa; Tohru Funahashi; Iichiro Shimomura
Age-dependent difference in factors affecting choice of system for self-monitoring of blood glucose.
Diabetes research and clinical practice 2008;79(1):103-7.
2007: Tomomi Fujisawa; Hiroshi Ikegami; Koji Nojima; Yumiko Kawabata; Shinsuke Noso; Katsuaki Asano; Yoshihisa Hiromine; Aya Fukai; Nobuyasu Shindo; Toshio Ogihara
Present state of diabetes management in the elderly, Japan.
Diabetes research and clinical practice 2007;77 Suppl 1():S82-6.
2007: Hiroshi Ikegami; Yumiko Kawabata; Shinsuke Noso; Tomomi Fujisawa; Toshio Ogihara
Genetics of type 1 diabetes in Asian and Caucasian populations.
Diabetes research and clinical practice 2007;77 Suppl 1():S116-21.
2007: Michiko Itoi-Babaya; Hiroshi Ikegami; Tomomi Fujisawa; Hironori Ueda; Koji Nojima; Naru Babaya; Misato Kobayashi; Shinsuke Noso; Yoshihiko Kawaguchi; Kaori Yamaji; Masao Shibata; Toshio Ogihara
Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes.
Diabetologia 2007;50(8):1641-8.
2007: Tomomi Fujisawa; Hiroshi Ikegami; Shinsuke Noso; Yoshihisa Hiromine; Yumiko Kawabata; Masanori Nishino; Kazuaki Asano; Toshio Ogihara
Renoprotective effect of N-type Ca channel blockade in diabetic nephropathy.
Journal of diabetes and its complications 2007;21(4):252-7.
2007: Yoshihisa Hiromine; Hiroshi Ikegami; Tomomi Fujisawa; Koji Nojima; Yumiko Kawabata; Shinsuke Noso; Katsuaki Asano; Aya Fukai; Toshio Ogihara
Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus.
Metabolism: clinical and experimental 2007;56(7):905-9.
2007: Shinsuke Noso; Tomomi Fujisawa; Yumiko Kawabata; Katsuaki Asano; Yoshihisa Hiromine; Aya Fukai; Toshio Ogihara; Hiroshi Ikegami
Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population.
The Journal of clinical endocrinology and metabolism 2007;92(6):2358-62.
2007: Katsuaki Asano; Hiroshi Ikegami; Tomomi Fujisawa; Masanori Nishino; Koji Nojima; Yumiko Kawabata; Shinsuke Noso; Yoshihisa Hiromine; Aya Fukai; Toshio Ogihara
Molecular scanning of interleukin-21 gene and genetic susceptibility to type 1 diabetes.
Human immunology 2007;68(5):384-91.
2007: Misato Kobayashi; Hiroshi Ikegami; Tomomi Fujisawa; Koji Nojima; Yumiko Kawabata; Shinsuke Noso; Naru Babaya; Michiko Itoi-Babaya; Kaori Yamaji; Yoshihisa Hiromine; Masao Shibata; Toshio Ogihara
Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin.
Diabetes 2007;56(1):239-47.
2006: Yoshihisa Hiromine; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Shinsuke Noso; Kaori Yamaji; Katsuaki Asano; Toshio Ogihara
Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility.
Annals of the New York Academy of Sciences 2006;1079():285-8.
2006: Yumiko Kawabata; Hiroshi Ikegami; Tomomi Fujisawa; Shinsuke Noso; Katsuaki Asano; Yoshihisa Hiromine; Toshio Ogihara
A second component of HLA-linked susceptibility to type 1 diabetes maps to class I region.
Annals of the New York Academy of Sciences 2006;1079():278-84.
2006: Tomomi Fujisawa; Hiroshi Ikegami; Shinsuke Noso; Kaori Yamaji; Koji Nojima; Naru Babaya; Michiko Itoi-Babaya; Yoshihisa Hiromine; Misato Kobayashi; Susumu Makino; Toshio Ogihara
MHC-linked susceptibility to type 1 diabetes in the NOD mouse: further localization of Idd16 by subcongenic analysis.
Annals of the New York Academy of Sciences 2006;1079():118-21.
2006: Kaori Yamaji; Hiroshi Ikegami; Tomomi Fujisawa; Shinsuke Noso; Koji Nojima; Naru Babaya; Michiko Itoi-Babaya; Misato Kobayashi; Yoshihisa Hiromine; Susumu Makino; Toshio Ogihara
Contribution of class III MHC to susceptibility to type 1 diabetes in the NOD mouse.
Annals of the New York Academy of Sciences 2006;1079():114-7.
2006: Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Shinsuke Noso; Toshio Ogihara
Genetics of type 1 diabetes: similarities and differences between Asian and Caucasian populations.
Annals of the New York Academy of Sciences 2006;1079():51-9.
2006: Katsuaki Asano; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Shinsuke Noso; Yoshihisa Hiromine; Toshio Ogihara
The gene for human IL-21 and genetic susceptibility to type 1 diabetes in the Japanese.
Annals of the New York Academy of Sciences 2006;1079():47-50.
2006: Shinsuke Noso; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Katsuaki Asano; Yoshihisa Hiromine; Shigetaka Sugihara; Inkyu Lee; Eiji Kawasaki; Takuya Awata; Toshio Ogihara
Association of SUMO4, as a candidate gene for IDDM5, with susceptibility to type 1 diabetes in Asian populations.
Annals of the New York Academy of Sciences 2006;1079():41-6.
2006: Koji Nojima; Hiroshi Ikegami; Tomomi Fujisawa; Hironori Ueda; Naru Babaya; Michiko Itoi-Babaya; Kaori Yamaji; Masao Shibata; Toshio Ogihara
Food hardness as environmental factor in development of type 2 diabetes.
Diabetes research and clinical practice 2006;74(1):1-7.
2006: Hiroshi Ikegami; Takuya Awata; Eiji Kawasaki; Tetsuro Kobayashi; Taro Maruyama; Koji Nakanishi; Akira Shimada; Shin Amemiya; Yumiko Kawabata; Susumu Kurihara; Shoichiro Tanaka; Yasuhiko Kanazawa; Mie Mochizuki; Toshio Ogihara
The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan.
The Journal of clinical endocrinology and metabolism 2006;91(3):1087-92.
2006: Tomomi Fujisawa; Hiroshi Ikegami; Toshio Ogihara
[Diabetic complications and their features in the elderly].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(1):112-6.
2006: Hiroshi Ikegami
[Tailored medicine for diabetes in the elderly].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(1):27-33.
2005: Shinsuke Noso; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Katsuaki Asano; Yoshihisa Hiromine; Masako Tsurumaru; Shigetaka Sugihara; Inkyu Lee; Eiji Kawasaki; Takuya Awata; Toshio Ogihara
Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes.
Diabetes 2005;54(12):3582-6.
2005: Kaori Yamaji; Hiroshi Ikegami; Tomomi Fujisawa; Shinsuke Noso; Koji Nojima; Naru Babaya; Michiko Itoi-Babaya; Susumu Makino; Tsutomu Sakamoto; Toshio Ogihara
Evidence for Cd101 but not Fcgr1 as candidate for type 1 diabetes locus, Idd10.
Biochemical and biophysical research communications 2005;331(2):536-42.
2005: Masanori Nishino; Hiroshi Ikegami; Tomomi Fujisawa; Yoshihiko Kawaguchi; Yumiko Kawabata; Maki Shintani; Masaya Ono; Toshio Ogihara
Functional polymorphism in Z-DNA-forming motif of promoter of SLC11A1 gene and type 1 diabetes in Japanese subjects: association study and meta-analysis.
Metabolism: clinical and experimental 2005;54(5):628-33.
2005: Masaya Ono; Hiroshi Ikegami; Tomomi Fujisawa; Koji Nojima; Yumiko Kawabata; Masanori Nishino; Hidenori Taniguchi; Michiko Itoi-Babaya; Naru Babaya; Kaori Inoue; Toshio Ogihara
Improvement of liver function parameters in patients with type 2 diabetes treated with thiazolidinediones.
Metabolism: clinical and experimental 2005;54(4):529-32.
2005: Naru Babaya; Hiroshi Ikegami; Tomomi Fujisawa; Koji Nojima; Michiko Itoi-Babaya; Kaori Inoue; Tamio Ohno; Masao Shibata; Toshio Ogihara
Susceptibility to streptozotocin-induced diabetes is mapped to mouse chromosome 11.
Biochemical and biophysical research communications 2005;328(1):158-64.
2005: Tomomi Fujisawa; Hiroshi Ikegami; Kaori Inoue; Yumiko Kawabata; Toshio Ogihara
Effect of two alpha-glucosidase inhibitors, voglibose and acarbose, on postprandial hyperglycemia correlates with subjective abdominal symptoms.
Metabolism: clinical and experimental 2005;54(3):387-90.
2005: Tomomi Fujisawa; Hiroshi Ikegami; Masaya Ono; Masanori Nishino; Shinsuke Noso; Yumiko Kawabata; Toshio Ogihara
Combination of half doses of angiotensin type 1 receptor antagonist and angiotensin-converting enzyme inhibitor in diabetic nephropathy.
American journal of hypertension 2005;18(1):13-7.
2004: Tomomi Fujisawa; Hiroshi Ikegami; Yoshihiko Kawaguchi; Koji Nojima; Yumiko Kawabata; Masaya Ono; Masanori Nishino; Shinsuke Noso; Hidenori Taniguchi; Mayumi Horiki; Michiko Itoi-Babaya; Naru Babaya; Kaori Inoue; Toshio Ogihara
Common genetic basis between type 1 and type 2 diabetes mellitus indicated by interview-based assessment of family history.
Diabetes research and clinical practice 2004;66 Suppl 1():S91-5.
2004: Hiroshi Ikegami; Tomomi Fujisawa; Tsutomu Sakamoto; Susumu Makino; Toshio Ogihara
Idd1 and Idd3 are necessary but not sufficient for development of type 1 diabetes in NOD mouse.
Diabetes research and clinical practice 2004;66 Suppl 1():S85-90.
2004: Mayumi Horiki; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Masaya Ono; Masanori Nishino; Kazuaki Shimamoto; Toshio Ogihara
Association of Pro12Ala polymorphism of PPARgamma gene with insulin resistance and related diseases.
Diabetes research and clinical practice 2004;66 Suppl 1():S63-7.
2004: Mayumi Horiki; Eiji Yamato; Hiroshi Ikegami; Toshio Ogihara; Jun-Ichi Miyazaki
Needleless in vivo gene transfer into muscles by jet injection in combination with electroporation.
The journal of gene medicine 2004;6(10):1134-8.
2004: Kaori Inoue; Hiroshi Ikegami; Tomomi Fujisawa; Shinsuke Noso; Koji Nojima; Naru Babaya; Michiko Itoi-Babaya; S Makimo; Toshio Ogihara
Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice.
Diabetologia 2004;47(4):739-47.
2004: Takashi Yamamoto; Eiji Yamato; Fumi Tashiro; T Sato; Shinsuke Noso; Hiroshi Ikegami; Shinji Tamura; Yuchio Yanagawa; J i Miyazaki
Development of autoimmune diabetes in glutamic acid decarboxylase 65 (GAD65) knockout NOD mice.
Diabetologia 2004;47(2):221-4.
2004: Hiroshi Ikegami; Tomomi Fujisawa; Toshio Ogihara
Mouse models of type 1 and type 2 diabetes derived from the same closed colony: genetic susceptibility shared between two types of diabetes.
ILAR journal / National Research Council, Institute of Laboratory Animal Resources 2004;45(3):268-77.
2004: Quihe Ji; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Masaya Ono; Masanori Nishino; Mitsuru Ohishi; Tomohiro Katsuya; Hiromi Rakugi; Toshio Ogihara
A common polymorphism of uncoupling protein 2 gene is associated with hypertension.
Journal of hypertension 2004;22(1):97-102.
2003: Hiroshi Ikegami; Tomomi Fujisawa; Susumu Makino; Toshio Ogihara
Congenic mapping and candidate sequencing of susceptibility genes for Type 1 diabetes in the NOD mouse.
Annals of the New York Academy of Sciences 2003;1005():196-204.
2003: Hiroshi Ikegami; Toshio Ogihara
[Genetic basis of arterial calcification for diabetes mellitus].
Clinical calcium 2003;13(9):1138-41.
2003: Hiroshi Ikegami; Toshio Ogihara
[Genetic susceptibility to diabetes and hypertension].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(7):1105-12.
2003: Kaori Inoue; Hiroshi Ikegami; Tomomi Fujisawa; Yumiko Kawabata; Maki Shintani; Koji Nijima; Ono Masaya; Masanori Nishino; Michiko Itoi-Babaya; Naru Babaya; Toshio Ogihara
High degree of mitochondrial 3243 mutation in gastric biopsy specimen in a patient with MELAS and diabetes complicated by marked gastrointestinal abnormalities.
Diabetes care 2003;26(7):2219.
2003: Naru Babaya; Hiroshi Ikegami; Tomomi Fujisawa; Koji Nojima; Michiko Itoi-Babaya; Kaori Inoue; Jun Nakura; Michiko Abe; Miyuki Yamamoto; Jin Ji Jin; Zhihong Wu; Tetsuro Miki; Masakatsu Fukuda; Toshio Ogihara
Association of I27L polymorphism of hepatocyte nuclear factor-1 alpha gene with high-density lipoprotein cholesterol level.
The Journal of clinical endocrinology and metabolism 2003;88(6):2548-51.
2003: Mayumi Horiki; Eiji Yamato; Shinsuke Noso; Hiroshi Ikegami; Toshio Ogihara; Jun-ichi Miyazaki
High-level expression of interleukin-4 following electroporation-mediated gene transfer accelerates Type 1 diabetes in NOD mice.
Journal of autoimmunity 2003;20(2):111-7.
2002: Shin Takiuchi; Hiromi Rakugi; Tohru Masuyama; Hiroshi Ikegami; Tomoko Nishikage; Maki Shintani; Norio Komai; Michiko Nagai; Kei Kamide; Jitsuo Higaki; Toshio Ogihara
Hypertension attenuates the efficacy of hypoglycemic therapy for preserving coronary flow reserve in patients with type 2 diabetes.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):893-900.
2002: Tomomi Fujisawa; Hiroshi Ikegami; Toshio Ogihara
[Problematic issues for diagnosis of diabetes mellitus in the elderly].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():740-5.
2002: Masaya Ono; Hiroshi Ikegami; Toshio Ogihara
[Glycated serum protein (GSP), glycated albumin (GA) and fructosamine].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 8():415-9.
2002: Yumiko Kawabata; Hiroshi Ikegami; Toshio Ogihara
[TNF-alpha].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():615-20.
2002: Hiroshi Ikegami; Toshio Ogihara
[Susceptibility genes for type 1 diabetes].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 7():377-82.
2002: Tomomi Fujisawa; Hiroshi Ikegami; Toshio Ogihara
[Clinical heterogeneity in elderly patients with diabetes mellitus].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 2002;39(4):390-2.
2002: Hiroshi Ikegami
Animal models of autoimmune polyglandular syndrome.
Endocrinology and metabolism clinics of North America 2002;31(2):431-9, viii.
2002: Maki Shintani; Hiroshi Ikegami; Tomomi Fujisawa; Yoshihiko Kawaguchi; Mitsuru Ohishi; Tomohiro Katsuya; Jitsuo Higaki; Kazuaki Shimamoto; Toshio Ogihara
Leptin gene polymorphism is associated with hypertension independent of obesity.
The Journal of clinical endocrinology and metabolism 2002;87(6):2909-12.
2002: Hiroshi Ikegami; Tomomi Fujisawa; Susumu Makino; Toshio Ogihara
Genetic dissection of type 1 diabetes susceptibility gene, Idd3, by ancestral haplotype congenic mapping.
Annals of the New York Academy of Sciences 2002;958():325-8.
2002: Naru Babaya; Hiroshi Ikegami; Tomomi Fujisawa; Hironori Ueda; Koji Nojima; Michiko Itoi-Babaya; Kazunori Yamada; Yoshiko Kawaguchi; Eiji Yamato; Susumu Makino; Toshio Ogihara
Sequence analysis of Tnf as a candidate for Idd16.
Autoimmunity 2002;35(1):63-6.
2002: Yumiko Kawabata; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Maki Shintani; Masaya Ono; Masanori Nishino; Yasuko Uchigata; Inkyu Lee; Toshio Ogihara
Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes.
Diabetes 2002;51(2):545-51.
2001: Y Hamada; Hiroshi Ikegami; H Ueda; Yoshihiko Kawaguchi; Eiji Yamato; Koji Nojima; K Yamada; Naru Babaya; M Shibata; Toshio Ogihara
Insulin secretion to glucose as well as nonglucose stimuli is impaired in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
Metabolism: clinical and experimental 2001;50(11):1282-5.
2001: Naru Babaya; Hiroshi Ikegami; Tomomi Fujisawa; Mizuo Hotta; Hironori Ueda; Maki Shintani; Koji Nojima; Yumiko Kawabata; Masaya Ono; Masanori Nishino; Michiko Itoi-Babaya; Hidenori Taniguchi; Shinsuke Noso; Mayumi Horiki; Kazunori Yamada; Yoshihiko Kawaguchi; Masakatsu Fukuda; Toshio Ogihara
Lack of association between hepatocyte nuclear factor-1beta gene and common forms of type 2 diabetes in the Japanese population.
Diabetes, nutrition & metabolism 2001;14(4):220-4.
2001: Hironori Ueda; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Koji Nojima; Naru Babaya; Kazunori Yamada; Masao Shibata; Eiji Yamato; Toshio Ogihara
Mapping and promoter sequencing of HNF-1beta gene in diabetes-prone and -resistant mice.
Diabetes research and clinical practice 2001;53(2):67-71.
2001: Masanori Nishino; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Yumiko Kawabata; Maki Shintani; Masaya Ono; Mayumi Horiki; E Kawasaki; Toshio Ogihara
Polymorphism in gene for islet autoantigen, IA-2, and type 1 diabetes in Japanese subjects.
Human immunology 2001;62(5):518-22.
2001: Kazunori Yamada; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Mizuo Hotta; Hironori Ueda; Maki Shintani; Koji Nojima; Yumiko Kawabata; Masaya Ono; Masanori Nishino; M Itoi; Naru Babaya; Masao Shibata; S Makino; Toshio Ogihara
Sequence analysis of candidate genes for common susceptibility to type 1 and type 2 diabetes in mice.
Endocrine journal 2001;48(2):241-7.
2000: Hironori Ueda; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Koji Nojima; Naru Babaya; K Yamada; Masao Shibata; Eiji Yamato; Toshio Ogihara
Age-dependent changes in phenotypes and candidate gene analysis in a polygenic animal model of Type II diabetes mellitus; NSY mouse.
Diabetologia 2000;43(7):932-8.
2000: Mitsuru Ohishi; Hiromi Rakugi; T Miki; Tomohiro Katsuya; Atsunori Okamura; K Kamide; Y Nakata; S Takami; Hiroshi Ikegami; Yoshihiro Yanagitani; Y Tabuchi; Y Kumahara; Jitsuo Higaki; Toshio Ogihara
Deletion polymorphism of angiotensin-converting enzyme gene is associated with postprandial hyperglycaemia in individuals undergoing general check-up.
Clinical and experimental pharmacology & physiology 2000;27(7):483-7.
2000: Yumiko Kawabata; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Mizuo Hotta; Hironori Ueda; Maki Shintani; Koji Nojima; Masaya Ono; Masanori Nishino; Hidenori Taniguchi; Shinsuke Noso; Kazunori Yamada; Naru Babaya; Toshio Ogihara
Age-related association of MHC class I chain-related gene A (MICA) with type 1 (insulin-dependent) diabetes mellitus.
Human immunology 2000;61(6):624-9.
2000: H Ueda; Hiroshi Ikegami; Tomomi Fujisawa; Koji Nojima; Naru Babaya; K Yamada; M Shibata; Eiji Yamato; Toshio Ogihara
Paternal-maternal effects on phenotypic characteristics in spontaneously diabetic Nagoya-Shibata-Yasuda mice.
Metabolism: clinical and experimental 2000;49(5):651-6.
2000: Arata Kimura; Masahide Ohmichi; Keiichi Tasaka; Yuki Kanda; Hiroshi Ikegami; Jun Hayakawa; Koji Hisamoto; Ken-ichirou Morishige; Shuji Hinuma; Hirohisa Kurachi; Yuji Murata
Prolactin-releasing peptide activation of the prolactin promoter is differentially mediated by extracellular signal-regulated protein kinase and c-Jun N-terminal protein kinase.
The Journal of biological chemistry 2000;275(5):3667-74.
1999: H Ueda; Hiroshi Ikegami; Toshio Ogihara
[Motilin].
Nihon rinsho. Japanese journal of clinical medicine 1999;57 Suppl():345-8.
1999: Tomomi Fujisawa; Hiroshi Ikegami; Yoshihiko Kawaguchi; Eiji Yamato; Youji Nakagawa; GQ Shen; Masakatsu Fukuda; Toshio Ogihara
Length rather than a specific allele of dinucleotide repeat in the 5' upstream region of the aldose reductase gene is associated with diabetic retinopathy.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(12):1044-7.
1999: Jun Hayakawa; Masahide Ohmichi; Hirohisa Kurachi; Hiroshi Ikegami; Arata Kimura; Taka-aki Matsuoka; H Jikihara; D Mercola; Yuji Murata
Inhibition of extracellular signal-regulated protein kinase or c-Jun N-terminal protein kinase cascade, differentially activated by cisplatin, sensitizes human ovarian cancer cell line.
The Journal of biological chemistry 1999;274(44):31648-54.
1999: Arata Kimura; Masahide Ohmichi; Hirohisa Kurachi; Hiroshi Ikegami; Jun Hayakawa; Keiichi Tasaka; Yuki Kanda; Yukihiro Nishio; H Jikihara; Nariaki Matsuura; Yuji Murata
Role of mitogen-activated protein kinase/extracellular signal-regulated kinase cascade in gonadotropin-releasing hormone-induced growth inhibition of a human ovarian cancer cell line.
Cancer research 1999;59(20):5133-42.
1999: Tomomi Fujisawa; Hiroshi Ikegami; Eiji Yamato; Yoshihiko Kawaguchi; H Ueda; Maki Shintani; Koji Nojima; Y Kawabata; M Ono; T Nishino; Shinsuke Noso; K Yamada; Naru Babaya; N Okamoto; Nobuyuki Ohguro; Masakatsu Fukuda; Toshio Ogihara
Association of plasma fibrinogen level and blood pressure with diabetic retinopathy, and renal complications associated with proliferative diabetic retinopathy, in Type 2 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association 1999;16(6):522-6.
1999: Hironori Ueda; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Eiji Yamato; Masao Shibata; Toshio Ogihara
Genetic analysis of late-onset type 2 diabetes in a mouse model of human complex trait.
Diabetes 1999;48(5):1168-74.
1999: Hiroshi Ikegami; Toshio Ogihara
[Diabetes mellitus in the elderly].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(3):632-6.
1998: Mizuo Hotta; Fumi Tashiro; Hiroshi Ikegami; Hitoshi Niwa; Toshio Ogihara; Junji Yodoi; Junichi Miyazaki
Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes.
The Journal of experimental medicine 1998;188(8):1445-51.
1998: Naru Babaya; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Youji Nakagawa; Yoshinosuke Hamada; Mizuo Hotta; Hironori Ueda; Maki Shintani; Koji Nojima; Yumiko Kawabata; Masaya Ono; Kazunori Yamada; GQ Shen; Masakatsu Fukuda; Toshio Ogihara
Hepatocyte nuclear factor-1alpha gene and non-insulin-dependent diabetes mellitus in the Japanese population.
Acta diabetologica 1998;35(3):150-3.
1998: Tomomi Fujisawa; Hiroshi Ikegami; Yoshihiko Kawaguchi; Toshio Ogihara
Meta-analysis of the association of Trp64Arg polymorphism of beta 3-adrenergic receptor gene with body mass index.
The Journal of clinical endocrinology and metabolism 1998;83(7):2441-4.
1998: GQ Shen; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Yoshinosuke Hamada; Hironori Ueda; Maki Shintani; Koji Nojima; Yumiko Kawabata; Kazunori Yamada; Naru Babaya; Toshio Ogihara
Asp905Tyr polymorphism of the gene for the skeletal muscle-specific glycogen-targeting subunit of protein phosphatase 1 in NIDDM.
Diabetes care 1998;21(7):1086-9.
1998: Hiroshi Ikegami; H Ueda; Y Kawaguchi; Toshio Ogihara
[Positional cloning of susceptibility genes for non-insulin-dependent diabetes mellitus].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1998;35(4):290-3.
1998: Mayumi Horiki; Atsuyuki Morishima; Hidehisa Yamagata; Hiromi Rakugi; Hiroshi Ikegami; Tsuneharu Miki; Toshio Ogihara
[A case of mild-type myotonic dystrophy with dementia and severe arteriosclerosis obliterans].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1998;35(2):136-8.
1998: J Fu; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Yumiko Kawabata; Y Hamada; Hironori Ueda; Maki Shintani; Koji Nojima; Naru Babaya; Q J Shen; Yasuko Uchigata; Tatsuhiko Urakami; Y Omori; K Shima; Toshio Ogihara
Association of distal chromosome 2q with IDDM in Japanese subjects.
Diabetologia 1998;41(2):228-32.
1998: Masaya Ono; Hiroshi Ikegami; Toshio Ogihara
[Glycated serum protein (GSP) glycated albumin (GA) and fructosamine].
Nihon rinsho. Japanese journal of clinical medicine 1998;56 Suppl 3():74-7.
1998: Tomomi Fujisawa; Hiroshi Ikegami; Yoshihiko Kawaguchi; Y Hamada; Hironori Ueda; Maki Shintani; M Fukuda; Toshio Ogihara
Meta-analysis of association of insertion/deletion polymorphism of angiotensin I-converting enzyme gene with diabetic nephropathy and retinopathy.
Diabetologia 1998;41(1):47-53.
1997: Yoshihiko Kawaguchi; Hiroshi Ikegami; Toshio Ogihara
[Prediction of type 1 diabetes by genetic analysis].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():339-44.
1997: Yoshihiko Kawaguchi; Hiroshi Ikegami; Toshio Ogihara
[Type 1 diabetes susceptibility genes on human chromosome 2q].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():392-6.
1997: Y Hamada; Hiroshi Ikegami; Toshio Ogihara
[TNF gene polymorphism and IDDM].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():382-7.
1997: Hiroshi Ikegami; Toshio Ogihara
[Susceptibility genes for IDDM].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():283-7.
1997: A Nohara; Masahide Ohmichi; Koji Koike; H Jikihara; Arata Kimura; Kensaku Masuhara; Hiroshi Ikegami; M Inoue; A Miyake; Yuji Murata
Prolactin stimulates mitogen-activated protein kinase in human leiomyoma cells.
Biochemical and biophysical research communications 1997;238(2):473-7.
1997: Y Hamada; Hiroshi Ikegami; Toshio Ogihara
[Insulin, as a regulating factor of blood pressure].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(8):1943-9.
1997: GQ Shen; Hiroshi Ikegami; Tomomi Fujisawa; Yoshinosuke Hamada; Kei Kamide; Hiromi Rakugi; Jitsuo Higaki; H Murakami; Kazuaki Shimamoto; Toshio Ogihara
Asp905Tyr polymorphism of protein phosphatase 1 G subunit gene in hypertension.
Hypertension 1997;30(2 Pt 1):236-9.
1997: Hiroshi Ikegami; Tomomi Fujisawa; Hiromi Rakugi; Y Kumahara; Toshio Ogihara
[Glucose tolerance and insulin resistance in the elderly].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1997;34(5):365-8.
1997: Yoshihiko Kawaguchi; Hiroshi Ikegami; GQ Shen; Youji Nakagawa; Tomomi Fujisawa; Yoshinosuke Hamada; Hironori Ueda; J Fu; Y Uchigata; Y Kitagawa; Y Omori; K Shima; Toshio Ogihara
Insulin gene region contributes to genetic susceptibility to, but may not to low incidence of, insulin-dependent diabetes mellitus in Japanese.
Biochemical and biophysical research communications 1997;233(1):283-7.
1997: Tomomi Fujisawa; Hiroshi Ikegami; Eiji Yamato; Y Hamada; Kei Kamide; Hiromi Rakugi; Jitsuo Higaki; H Murakami; Kazuaki Shimamoto; Toshio Ogihara
Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system.
American journal of hypertension 1997;10(1):101-5.
1997: Eiji Yamato; Hiroshi Ikegami; Yoshihiko Kawaguchi; Tomomi Fujisawa; Y Hamada; Hironori Ueda; Maki Shintani; Toshio Ogihara
Insulin-dependent diabetes mellitus associated with autoimmune thyroiditis and rheumatoid arthritis.
The American journal of the medical sciences 1997;313(1):64-6.
1996: A Nohara; Masahide Ohmichi; Koji Koike; N Masumoto; M Kobayashi; M Akahane; Hiroshi Ikegami; K Hirota; A Miyake; Yuji Murata
The role of mitogen-activated protein kinase in oxytocin-induced contraction of uterine smooth muscle in pregnant rat.
Biochemical and biophysical research communications 1996;229(3):938-44.
1996: Maki Shintani; Hiroshi Ikegami; Eiji Yamato; Yoshihiko Kawaguchi; Tomomi Fujisawa; Youji Nakagawa; Yoshinosuke Hamada; H Ueda; T Miki; Toshio Ogihara
A novel microsatellite polymorphism in the human OB gene: a highly polymorphic marker for linkage analysis.
Diabetologia 1996;39(11):1398-401.
1996: Eiji Yamato; Hiroshi Ikegami; J I Miyazaki; Toshio Ogihara
Identification of genes regulated by glucose in a pancreatic beta-cell line by a new method for subtraction of mRNA.
Diabetologia 1996;39(11):1293-8.
1996: M Ono; Takahiro Niinobu; Y Yamanaka; O Yasuda; Hiromi Rakugi; Hiroshi Ikegami; T Miki; Toshio Ogihara
[Primary biliary cirrhosis with polymyositis successfully treated with prednisolone and ursodeoxycholic acid].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1996;33(10):779-82.
1996: Takashi Maeda; Hiroshi Ikegami; Masahiro Sakata; Masaaki Yamaguchi; K Wada; Koji Koike; K Adachi; Hirohisa Kurachi; K Hirota; A Miyake
Intraventricular administration of estradiol modulates rat prolactin secretion and synthesis.
Journal of endocrinological investigation 1996;19(9):586-92.
1996: Hiroshi Ikegami; Eiji Yamato; Tomomi Fujisawa; Yoshinosuke Hamada; Y Fujioka; Hiromi Rakugi; Jitsuo Higaki; H Murakami; K Shimamoto; Toshio Ogihara
Analysis of candidate genes for insulin resistance in essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 1996;19 Suppl 1():S31-4.
1996: Eiji Yamato; Hiroshi Ikegami; K Takekawa; Tomomi Fujisawa; Youji Nakagawa; Yoshinosuke Hamada; H Ueda; Toshio Ogihara
Internal marker for quantitative analysis of mRNA by reverse transcriptase-polymerase chain reaction in pancreatic beta cells.
Diabetologia 1996;39(6):747-8.
1996: A Nishibe; Shigeto Morimoto; K Hirota; O Yasuda; Hiroshi Ikegami; T Yamamoto; Keisuke Fukuo; T Onishi; Toshio Ogihara
[Effect of estriol and bone mineral density of lumbar vertebrae in elderly and postmenopausal women].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1996;33(5):353-9.
1996: Tomomi Fujisawa; Hiroshi Ikegami; Eiji Yamato; K Takekawa; Youji Nakagawa; Yoshinosuke Hamada; T Oga; H Ueda; Maki Shintani; Masakatsu Fukuda; Toshio Ogihara
Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain.
Diabetologia 1996;39(3):349-52.
1995: Tomomi Fujisawa; Hiroshi Ikegami; Yoshihiko Kawaguchi; Eiji Yamato; K Takekawa; Youji Nakagawa; Yoshinosuke Hamada; H Ueda; K Shima; Toshio Ogihara
Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.
Diabetologia 1995;38(12):1493-5.
1995: Yoshinosuke Hamada; Hiroshi Ikegami; Y Fujioka; Eiji Yamato; K Takekawa; Tomomi Fujisawa; Youji Nakagawa; H Ueda; J Fu; GQ Shen
The glycogen synthase gene in NIDDM and hypertension.
Diabetologia 1995;38(10):1249-50.
1995: Hiroshi Ikegami; S Makino; Eiji Yamato; Yoshihiko Kawaguchi; H Ueda; T Sakamoto; K Takekawa; Toshio Ogihara
Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping.
The Journal of clinical investigation 1995;96(4):1936-42.
1995: J Fu; Hiroshi Ikegami; Eiji Yamato; Yoshihiko Kawaguchi; K Takekawa; Tomomi Fujisawa; Youji Nakagawa; Yoshinosuke Hamada; H Ueda; GQ Shen
Detection of MspI RFLP in human THY1 gene by the polymerase chain reaction.
The Japanese journal of human genetics 1995;40(3):279-80.
1995: Y Fujioka; K Takekawa; Youji Nakagawa; Yoshinosuke Hamada; Hiroshi Ikegami; Eiji Yamato; Tomomi Fujisawa; H Ueda; T Miki; Toshio Ogihara
Insulin receptor gene polymorphism and hyperinsulinemia in hypertensive patients.
Hypertension research : official journal of the Japanese Society of Hypertension 1995;18(3):215-8.
1995: Tomomi Fujisawa; Hiroshi Ikegami; Eiji Yamato; K Takekawa; Youji Nakagawa; Yoshinosuke Hamada; H Ueda; Masakatsu Fukuda; Toshio Ogihara
A mutation in the glucagon receptor gene (Gly40Ser): heterogeneity in the association with diabetes mellitus.
Diabetologia 1995;38(8):983-5.
1995: Tomomi Fujisawa; Hiroshi Ikegami; GQ Shen; Eiji Yamato; K Takekawa; Youji Nakagawa; Yoshinosuke Hamada; H Ueda; Hiromi Rakugi; Jitsuo Higaki
Angiotensin I-converting enzyme gene polymorphism is associated with myocardial infarction, but not with retinopathy or nephropathy, in NIDDM.
Diabetes care 1995;18(7):983-5.
1995: H Ueda; Hiroshi Ikegami; Eiji Yamato; J Fu; Masakatsu Fukuda; G Shen; Yoshihiko Kawaguchi; K Takekawa; Y Fujioka; Tomomi Fujisawa
The NSY mouse: a new animal model of spontaneous NIDDM with moderate obesity.
Diabetologia 1995;38(5):503-8.
1995: Masakatsu Fukuda; Hiroshi Ikegami; Yoshihiko Kawaguchi; T Sano; Toshio Ogihara
Antioxidant, probucol, can inhibit the generation of hydrogen peroxide in islet cells induced by macrophages and prevent islet cell destruction in NOD mice.
Biochemical and biophysical research communications 1995;209(3):953-8.
1995: Youji Nakagawa; Hiroshi Ikegami; Eiji Yamato; K Takekawa; Tomomi Fujisawa; Yoshinosuke Hamada; H Ueda; Y Uchigata; T Miki; Y Kumahara
A new mitochondrial DNA mutation associated with non-insulin-dependent diabetes mellitus.
Biochemical and biophysical research communications 1995;209(2):664-8.
1995: H Ueda; Hiroshi Ikegami; Toshio Ogihara
[Motilin].
Nihon rinsho. Japanese journal of clinical medicine 1995;53 Su Pt 2():640-3.
1995: Toshio Ogihara; Hiromi Rakugi; Hiroshi Ikegami; Hiroshi Mikami; Kazuko Masuo
Enhancement of insulin sensitivity by troglitazone lowers blood pressure in diabetic hypertensives.
American journal of hypertension 1995;8(3):316-20.
1995: T Sawada; Koji Koike; Yuki Kanda; Hiroshi Ikegami; H Jikihara; Takashi Maeda; Y Osako; K Hirota; A Miyake
Interleukin-6 stimulates cell proliferation of rat pituitary clonal cell lines in vitro.
Journal of endocrinological investigation 1995;18(2):83-90.
1994: Takashi Maeda; Masaaki Yamaguchi; Tetsuya Taga; Tadamitsu Kishimoto; K Wada; Hiroshi Ikegami; Hirohisa Kurachi; A Miyake
Decidua is a possible source of serum mouse soluble interleukin-6 receptor (msIL-6R): gestational profile of serum msIL-6R concentration.
Biochemical and biophysical research communications 1994;205(2):998-1003.
1994: Shigeto Morimoto; E Koh; Keisuke Fukuo; Jitsuo Higaki; Hiroshi Ikegami; T Miki; T Hata; Toshio Ogihara
Long-term effects of pravastatin on serum lipid levels in elderly patients with hypercholesterolemia.
Clinical therapeutics 1994;16(5):793-803.
1994: T Mizutani; Y Nishikawa; H Adachi; T Enomoto; Hiroshi Ikegami; Hirohisa Kurachi; T Nomura; A Miyake
Identification of estrogen receptor in human adipose tissue and adipocytes.
The Journal of clinical endocrinology and metabolism 1994;78(4):950-4.
1994: Shigeto Morimoto; E Koh; Keisuke Fukuo; Hiroshi Mikami; Hiroshi Ikegami; T Miki; T Hata; Toshio Ogihara
[Effects of pravastatin administration for 12 months on serum lipid levels in aged patients with hypercholesterolemia].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1994;31(4):310-7.
1994: K Takekawa; Hiroshi Ikegami; Masakatsu Fukuda; H Ueda; Yoshihiko Kawaguchi; Y Fujioka; Tomomi Fujisawa; Toshio Ogihara
Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population.
Diabetes research and clinical practice 1994;23(3):141-6.
1994: Eiji Yamato; Hiroshi Ikegami; Y Tahara; Masakatsu Fukuda; T Cha; Yoshihiko Kawaguchi; Y Fujioka; Y Noma; K Shima; Toshio Ogihara
Glyburide enhances insulin gene expression and glucose-induced insulin release in isolated rat islets.
Biochemical and biophysical research communications 1994;199(1):327-33.
1994: Yoshihiko Kawaguchi; Hiroshi Ikegami; Masakatsu Fukuda; K Takekawa; Y Fujioka; Tomomi Fujisawa; H Ueda; Toshio Ogihara
Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.
Life sciences 1994;54(26):2049-53.
1993: Eiji Yamato; Hiroshi Ikegami; Y Tahara; Masakatsu Fukuda; T Cha; Yoshihiko Kawaguchi; Y Fujioka; Y Noma; K Shima; Toshio Ogihara
Cellular mechanism of glyburide-induced insulin gene expression in isolated rat islets.
Biochemical and biophysical research communications 1993;197(2):957-64.
1993: Koji Koike; K Kadowaki; K Hirota; Masahide Ohmichi; Hiroshi Ikegami; T Sawada; A Miyake; O Tanizawa
Prolactin stimulates [3H]dopamine release from dispersed rat tubero-infundibular dopaminergic neurons and dopamine decreases gonadotropin-releasing hormone release induced by calcium ionophore.
Acta endocrinologica 1993;129(6):548-53.
1993: Y Nishikawa; Hiroshi Ikegami; Masahiro Sakata; T Mizutani; Ken-ichirou Morishige; Hirohisa Kurachi; K Hirota; A Miyake; O Tanizawa
Ovariectomy increases the level of estrogen receptor mRNA and estrogen receptor binding sites in female rat adipose tissue.
Journal of endocrinological investigation 1993;16(8):579-83.
1993: Yoshihiko Kawaguchi; Hiroshi Ikegami; Masakatsu Fukuda; Y Fujioka; K Shima; Toshio Ogihara
Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in Japanese.
Diabetes research and clinical practice 1993;21(2-3):103-7.
1993: Masahiro Sakata; Hirohisa Kurachi; Hiroshi Ikegami; H Jikihara; Ken-ichirou Morishige; A Miyake; N Terakawa; O Tanizawa
Autocrine growth mechanism by transforming growth factor (TGF)-beta 1 and TGF-beta 1-receptor regulation by epidermal growth factor in a human endometrial cancer cell line IK-90.
International journal of cancer. Journal international du cancer 1993;54(5):862-7.
1993: Y Fujioka; Hiroshi Ikegami; Masakatsu Fukuda; Yoshihiko Kawaguchi; K Takegawa; T Fujisawa; H Ueda; T Miki; Y Kumahara; Toshio Ogihara
[The effect on age for the relationship between hypertension and glucose intolerance].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1993;30(7):622-5.
1993: Y Nishikawa; Hiroshi Ikegami; H Jikihara; Koji Koike; N Masumoto; K Kasahara; Keiichi Tasaka; K Hirota; A Miyake; O Tanizawa
Effects of thyrotropin-releasing hormone and phorbol ester on dopamine release from dispersed rat tuberoinfundibular dopaminergic neurons.
Peptides 1993;14(4):839-44.
1993: R Kobayashi; M Nagano; F Nakamura; Jitsuo Higaki; Y Fujioka; Hiroshi Ikegami; Hiroshi Mikami; N Kawaguchi; S Onishi; Toshio Ogihara
Role of angiotensin II in high fructose-induced left ventricular hypertrophy in rats.
Hypertension 1993;21(6 Pt 2):1051-5.
1993: M Shintani; Hiroshi Ikegami; Yoshihiko Kawaguchi; H Hosotani; T Miki; Toshio Ogihara
[Two cases of Werner's syndrome treated with penetrating keratoplasty].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1993;30(6):503-5.
1993: Hiroshi Ikegami; Yoshihiko Kawaguchi; H Ueda; Masakatsu Fukuda; K Takakawa; Y Fujioka; Tomomi Fujisawa; K Uchida; Toshio Ogihara
MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region.
Biochemical and biophysical research communications 1993;192(2):677-82.
1993: Hiroshi Ikegami; Masakatsu Fukuda; Yoshihiko Kawaguchi; Y Fujioka; H Ueda; Toshio Ogihara
A microsatellite polymorphism in the human insulin receptor gene: a highly informative marker for linkage analysis.
Diabetes research and clinical practice 1993;20(1):7-10.
1993: H Jikihara; Hiroshi Ikegami; Koji Koike; K Wada; Ken-ichirou Morishige; Hirohisa Kurachi; K Hirota; A Miyake; O Tanizawa
Intraventricular administration of histidyl-proline-diketopiperazine [Cyclo(His-Pro)] suppresses prolactin secretion and synthesis: a possible role of Cyclo(His-Pro) as dopamine uptake blocker in rat hypothalamus.
Endocrinology 1993;132(3):953-8.
1993: K Takekawa; Hiroshi Ikegami; Toshio Ogihara
[Congenital CBG deficiency].
Ryōikibetsu shōkōgun shirīzu 1993;(1):481-3.
1992: T Cha; Hiroshi Ikegami; Masakatsu Fukuda; Eiji Yamato; Yoshihiko Kawaguchi; Y Tahara; Toshio Ogihara
[Clinical characteristic of elderly patients with insulin-dependent diabetes mellitus].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1992;29(12):931-7.
1992: E Uejima; Hiroshi Mikami; Shigeto Morimoto; Hiroshi Ikegami; T Miki; Kazuko Masuo; C Yanaihara; Toshio Ogihara
[Drug compliance in the elderly].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1992;29(11):855-63.
1992: H Yoneda; Hiroshi Ikegami; Yoko Yamamoto; Eiji Yamato; T Cha; Yoshihiko Kawaguchi; Y Tahara; Toshio Ogihara
Analysis of early-phase insulin responses in nonobese subjects with mild glucose intolerance.
Diabetes care 1992;15(11):1517-21.
1992: Hiroshi Ikegami; Yoshihiko Kawaguchi; Eiji Yamato; S Kuwata; K Tokunaga; Y Noma; K Shima; Toshio Ogihara
Analysis by the polymerase chain reaction of histocompatibility leucocyte antigen-DR9-linked susceptibility to insulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism 1992;75(5):1381-5.
1992: Shigeto Morimoto; T Miki; Hiroshi Ikegami; Hiroshi Mikami; Keisuke Fukuo; Toshio Ogihara
[Dysuria in male elderly outpatients evaluated by a questionnaire survey].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1992;29(10):765-8.
1992: Hiroshi Ikegami; H Jikihara; Koji Koike; Ken-ichirou Morishige; Hirohisa Kurachi; N Yamamoto; K Hirota; A Miyake; O Tanizawa
Intraventricular administration of thyrotrophin-releasing hormone (TRH) suppresses prolactin secretion and synthesis: a possible involvement of dopamine release by TRH from rat hypothalamus.
The Journal of endocrinology 1992;133(1):59-66.
1992: M Hotta; Masakatsu Fukuda; Hiroshi Ikegami; Shigeto Morimoto; K Shima; Toshio Ogihara
[A case of hyperinsulinemia due to hypersecretion of incretin].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1992;29(2):140-4.
1992: M Ohishi; S Kitano; Jitsuo Higaki; Shigeto Morimoto; Hiroshi Ikegami; H Tanabe; Toshio Ogihara
[A case of late-onset Pick's disease with polyuria].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 1992;29(2):135-9.
1991: H Jikihara; Hiroshi Ikegami; Masahiro Sakata; Ken-ichirou Morishige; Y Fujita; Hirohisa Kurachi; A Miyake; O Tanizawa; N Terakawa
Epidermal growth factor attenuates cell proliferation by down-regulating the transforming growth factor-beta receptor in the osteoblastic cell line MC3T3-E1.
Bone and mineral 1991;15(2):125-35.
1991: Hiroshi Ikegami; Masakatsu Fukuda; Yoshihiko Kawaguchi; Y Fujioka; Toshio Ogihara
Detection of PstI RFLP in human ADA by the polymerase chain reaction.
Nucleic acids research 1991;19(19):5448.
1991: T Cha; Y Tahara; Hiroshi Ikegami; Masakatsu Fukuda; H Yoneda; Eiji Yamato; Yoko Yamamoto; Y Noma; K Shima; Toshio Ogihara
Urinary C-peptide as an index of unstable glycemic control in insulin-dependent diabetes mellitus (IDDM)
Diabetes research and clinical practice 1991;13(3):181-7.
1991: Masaaki Yamaguchi; Koji Koike; Y Yoshimoto; Hiroshi Ikegami; A Miyake; O Tanizawa
Effect of TNF-alpha on prolactin secretion from rat anterior pituitary and dopamine release from the hypothalamus: comparison with the effect of interleukin-1 beta.
Endocrinologia japonica 1991;38(4):357-61.
1991: T Cha; Y Tahara; Eiji Yamato; H Yoneda; Hiroshi Ikegami; Y Noma; K Shima; Toshio Ogihara
Renal handling of glycated albumin in non-insulin-dependent diabetes mellitus with nephropathy.
Diabetes research and clinical practice 1991;12(3):149-56.
1991: Koji Koike; K Hirota; Masahide Ohmichi; K Kadowaki; Hiroshi Ikegami; Masaaki Yamaguchi; A Miyake; O Tanizawa
Tumor necrosis factor-alpha increases release of arachidonate and prolactin from rat anterior pituitary cells.
Endocrinology 1991;128(6):2791-8.
1990: Hiroshi Ikegami; K Hirota; Koji Koike; H Jikihara; A Miyake; T Aono; O Tanizawa
5-Hydroxyeicosatetraenoic acid and phorbol ester stimulate prolactin release from rat anterior pituitary cells by different mechanisms.
Endocrinologia japonica 1990;37(6):809-17.
1990: Hiroshi Ikegami; Toshio Ogihara
[Clinical significance of analysis of glycated serum protein, glycated albumin and fructosamine in the diagnosis of diabetic diseases].
Nihon rinsho. Japanese journal of clinical medicine 1990;48 Suppl():395-400.
1990: Y Tahara; Masakatsu Fukuda; Yoko Yamamoto; Y Noma; Eiji Yamato; T Cha; H Yoneda; Hiroshi Ikegami; M Hirota; K Shima
Metabolism of intravenously administered maltose in renal tubules in humans.
The American journal of clinical nutrition 1990;52(4):689-93.
1990: Eiji Yamato; Hiroshi Ikegami; Y Tahara; T Cha; H Yoneda; Y Noma; K Shima; Toshio Ogihara
Role of protein kinase C in the regulation of glucagon gene expression by arginine.
Biochemical and biophysical research communications 1990;171(2):898-904.
1990: Hiroshi Ikegami; Y Tahara; T Cha; Eiji Yamato; Toshio Ogihara; Y Noma; K Shima
Aspartic acid at position 57 of the HLA-DQ beta chain is not protective against insulin-dependent diabetes mellitus in Japanese people.
Journal of autoimmunity 1990;3(2):167-74.
1990: Eiji Yamato; Y Noma; Y Tahara; Hiroshi Ikegami; Yoko Yamamoto; T Cha; H Yoneda; Toshio Ogihara; C Ohboshi; M Hirota
Suppression of synthesis and release of glucagon by glucagon-like peptide-1 (7-36 amide) without affect on mRNA level in isolated rat islets.
Biochemical and biophysical research communications 1990;167(2):431-7.
1989: T Nishizaki; Hiroshi Ikegami; K Tasaka; K Hirota; A Miyake; O Tanizawa
Mechanism of release of beta-endorphin from rat pituitary cells. Role of lipoxygenase products of arachidonic acid.
Neuroendocrinology 1989;49(5):483-8.
1988: N Terakawa; M Inoue; I Shimizu; Hiroshi Ikegami; T Mizutani; Masahiro Sakata; O Tanizawa; K Matsumoto
Preliminary report on the use of danazol in the treatment of endometrial adenomatous hyperplasia.
Cancer 1988;62(12):2618-21.
1988: A Miyake; T Nishizaki; Hiroshi Ikegami; Koji Koike; K Hirota; O Tanizawa
Possible involvement of lipoxygenase pathway of arachidonic acid in rat pituitary hormone release in vitro.
Journal of endocrinological investigation 1988;11(11):805-8.
1988: N Terakawa; Hiroshi Ikegami; I Shimizu; M Inoue; O Tanizawa; K Matsumoto
Inhibitory effects of danazol and medroxyprogesterone acetate on [3H]thymidine incorporation in human endometrial cancer cells.
Journal of steroid biochemistry 1988;31(1):131-5.
1988: N Terakawa; I Shimizu; Hiroshi Ikegami; O Tanizawa; K Matsumoto
4-Hydroxytamoxifen binds to estrogen receptors and inhibits the growth of human endometrial cancer cells in vitro.
Cancer 1988;61(7):1312-5.
1988: Masakatsu Fukuda; A Tanaka; Y Tahara; Hiroshi Ikegami; Yoko Yamamoto; Y Kumahara; K Shima
Correlation between minimal secretory capacity of pancreatic beta-cells and stability of diabetic control.
Diabetes 1988;37(1):81-8.
1987: N Terakawa; Hiroshi Ikegami; I Shimizu; T Aono; O Tanizawa; K Matsumoto
Growth inhibition by danazol in a human endometrial cancer cell line with estrogen-independent progesterone receptors.
Journal of steroid biochemistry 1987;28(5):571-4.