Machiko Ikegami

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Korfhagen Thomas R; Le Cras Timothy D; Davidson Cynthia R; Schmidt Stephanie M; Ikegami Machiko; Whitsett Jeffrey A; Hardie William D
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
Ikegami Machiko; Weaver Timothy E; Grant Shawn N; Whitsett Jeffrey A
Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation.
Kallapur Suhas G; Moss Timothy J M; Auten Richard L; Nitsos Ilias; Pillow J Jane; Kramer Boris W; Maeda Dean Y; Newnham John P; Ikegami Machiko; Jobe Alan H
IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung.

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All Publications

2009: Korfhagen Thomas R; Le Cras Timothy D; Davidson Cynthia R; Schmidt Stephanie M; Ikegami Machiko; Whitsett Jeffrey A; Hardie William D
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2009;41(5):562-72.
2009: Ikegami Machiko; Weaver Timothy E; Grant Shawn N; Whitsett Jeffrey A
Pulmonary surfactant surface tension influences alveolar capillary shape and oxygenation.
American journal of respiratory cell and molecular biology 2009;41(4):433-9.
2009: Kallapur Suhas G; Moss Timothy J M; Auten Richard L; Nitsos Ilias; Pillow J Jane; Kramer Boris W; Maeda Dean Y; Newnham John P; Ikegami Machiko; Jobe Alan H
IL-8 signaling does not mediate intra-amniotic LPS-induced inflammation and maturation in preterm fetal lamb lung.
American journal of physiology. Lung cellular and molecular physiology 2009;297(3):L512-9.
2009: Xu Yan; Saegusa Chika; Schehr Angelica; Grant Shawn; Whitsett Jeffrey A; Ikegami Machiko
C/EBP{alpha} is required for pulmonary cytoprotection during hyperoxia.
American journal of physiology. Lung cellular and molecular physiology 2009;297(2):L286-98.
2009: Ikegami Machiko; Grant Shawn; Korfhagen Thomas; Scheule Ronald K; Whitsett Jeffrey A
Surfactant protein-D regulates the postnatal maturation of pulmonary surfactant lipid pool sizes.
Journal of applied physiology (Bethesda, Md. : 1985) 2009;106(5):1545-52.
2009: Kallapur Suhas G; Nitsos Ilias; Moss Timothy J M; Polglase Graeme R; Pillow J Jane; Cheah Fook-Choe; Kramer Boris W; Newnham John P; Ikegami Machiko; Jobe Alan H
IL-1 mediates pulmonary and systemic inflammatory responses to chorioamnionitis induced by lipopolysaccharide.
American journal of respiratory and critical care medicine 2009;179(10):955-61.
2009: Besnard Valérie; Wert Susan E; Stahlman Mildred T; Postle Anthony D; Xu Yan; Ikegami Machiko; Whitsett Jeffrey A
Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts.
The Journal of biological chemistry 2009;284(6):4018-30.
2009: Moss Timothy J M; Nitsos Ilias; Knox Christine L; Polglase Graeme R; Kallapur Suhas G; Ikegami Machiko; Jobe Alan H; Newnham John P
Ureaplasma colonization of amniotic fluid and efficacy of antenatal corticosteroids for preterm lung maturation in sheep.
American journal of obstetrics and gynecology 2009;200(1):96.e1-6.
2008: Polglase Graeme R; Hillman Noah H; Pillow J Jane; Cheah Fook-Choe; Nitsos Ilias; Moss Timothy J M; Kramer Boris W; Ikegami Machiko; Kallapur Suhas G; Jobe Alan H
Positive end-expiratory pressure and tidal volume during initial ventilation of preterm lambs.
Pediatric research 2008;64(5):517-22.
2008: Wan Huajing; Luo Fengming; Wert Susan E; Zhang Liqian; Xu Yan; Ikegami Machiko; Maeda Yutaka; Bell Sheila M; Whitsett Jeffrey A
Kruppel-like factor 5 is required for perinatal lung morphogenesis and function.
Development (Cambridge, England) 2008;135(15):2563-72.
2008: Kida Hiroshi; Mucenski Michael L; Thitoff Angela R; Le Cras Timothy D; Park Kwon-Sik; Ikegami Machiko; Müller Werner; Whitsett Jeffrey A
GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium.
The American journal of pathology 2008;172(6):1542-54.
2008: Hardie William D; Davidson Cynthia; Ikegami Machiko; Leikauf George D; Le Cras Timothy D; Prestridge Adrienne; Whitsett Jeffrey A; Korfhagen Thomas R
EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.
American journal of physiology. Lung cellular and molecular physiology 2008;294(6):L1217-25.
2008: Matsuzaki Yohei; Besnard Valérie; Clark Jean C; Xu Yan; Wert Susan E; Ikegami Machiko; Whitsett Jeffrey A
STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells.
American journal of respiratory cell and molecular biology 2008;38(5):551-8.
2008: Hillman Noah H; Moss Timothy J M; Nitsos Ilias; Kramer Boris W; Bachurski Cindy J; Ikegami Machiko; Jobe Alan H; Kallapur Suhas G
Toll-like receptors and agonist responses in the developing fetal sheep lung.
Pediatric research 2008;63(4):388-93.
2008: Lin Sui; Ikegami Machiko; Xu Yan; Bosserhoff Anja-Katrin; Malkinson Alvin M; Shannon John M
Misexpression of MIA disrupts lung morphogenesis and causes neonatal death.
Developmental biology 2008;316(2):441-55.
2008: Moss Timothy J M; Knox Christine L; Kallapur Suhas G; Nitsos Ilias; Theodoropoulos Christina; Newnham John P; Ikegami Machiko; Jobe Alan H
Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep.
American journal of obstetrics and gynecology 2008;198(1):122.e1-8.
2007: Jobe Alan H; Moss Timothy J M; Nitsos Ilias; Ikegami Machiko; Kallapur Suhas G; Newnham John P
Betamethasone for lung maturation: testing dose and formulation in fetal sheep.
American journal of obstetrics and gynecology 2007;197(5):523.e1-6.
2007: Ikegami Machiko; Scoville Elizabeth A; Grant Shawn; Korfhagen Thomas; Brondyk William; Scheule Ronald K; Whitsett Jeffrey A
Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation.
Chest 2007;132(5):1447-54.
2007: Hardie William D; Korfhagen Thomas R; Sartor Maureen A; Prestridge Adrienne; Medvedovic Mario; Le Cras Timothy D; Ikegami Machiko; Wesselkamper Scott C; Davidson Cynthia; Dietsch Maggie; Nichols William; Whitsett Jeffrey A; Leikauf George D
Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.
American journal of respiratory cell and molecular biology 2007;37(3):309-21.
2007: Kramer Elizabeth L; Deutsch Gail H; Sartor Maureen A; Hardie William D; Ikegami Machiko; Korfhagen Thomas R; Le Cras Timothy D
Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis.
American journal of physiology. Lung cellular and molecular physiology 2007;293(2):L314-27.
2007: Pillow J Jane; Hillman Noah; Moss Timothy J M; Polglase Graeme; Bold Geoff; Beaumont Chris; Ikegami Machiko; Jobe Alan H
Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs.
American journal of respiratory and critical care medicine 2007;176(1):63-9.
2007: Xu Yan; Ikegami Machiko; Wang Yanhua; Matsuzaki Yohei; Whitsett Jeffrey A
Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.
BMC genomics 2007;8():455.
2006: Davé Vrushank; Childs Tawanna; Xu Yan; Ikegami Machiko; Besnard Valérie; Maeda Yutaka; Wert Susan E; Neilson Joel R; Crabtree Gerald R; Whitsett Jeffrey A
Calcineurin/Nfat signaling is required for perinatal lung maturation and function.
The Journal of clinical investigation 2006;116(10):2597-609.
2006: Akei Hiroko; Whitsett Jeffrey A; Buroker Michelle; Ninomiya Takafumi; Tatsumi Haruyuki; Weaver Timothy E; Ikegami Machiko
Surface tension influences cell shape and phagocytosis in alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology 2006;291(4):L572-9.
2006: Kingma Paul S; Zhang Liqian; Ikegami Machiko; Hartshorn Kevan; McCormack Francis X; Whitsett Jeffrey A
Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D.
The Journal of biological chemistry 2006;281(34):24496-505.
2006: Zhang Liqian; Ikegami Machiko; Korfhagen Thomas R; McCormack Francis X; Yoshida Mitsuhiro; Senior Robert M; Shipley J Michael; Shapiro Steven D; Whitsett Jeffrey A
Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis.
American journal of physiology. Lung cellular and molecular physiology 2006;291(2):L181-90.
2006: Matsuzaki Yohei; Xu Yan; Ikegami Machiko; Besnard Valérie; Park Kwon-Sik; Hull William M; Wert Susan E; Whitsett Jeffrey A
Stat3 is required for cytoprotection of the respiratory epithelium during adenoviral infection.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(1):527-37.
2006: Kallapur Suhas G; Ikegami Machiko
Physiological consequences of intrauterine insults.
Paediatric respiratory reviews 2006;7(2):110-6.
2006: Ikegami Machiko; Carter Karen; Bishop Kimberly; Yadav Annuradha; Masterjohn Elizabeth; Brondyk William; Scheule Ronald K; Whitsett Jeffrey A
Intratracheal recombinant surfactant protein d prevents endotoxin shock in the newborn preterm lamb.
American journal of respiratory and critical care medicine 2006;173(12):1342-7.
2006: Ikegami Machiko
Surfactant catabolism.
Respirology (Carlton, Vic.) 2006;11 Suppl():S24-7.
2005: Wilson Teicha C; Bachurski Cindy J; Ikegami Machiko; Jobe Alan H; Kallapur Suhas G
Pulmonary and systemic induction of SAA3 after ventilation and endotoxin in preterm lambs.
Pediatric research 2005;58(6):1204-9.
2005: Ikegami Machiko; Whitsett Jeffrey A; Martis Prithy C; Weaver Timothy E
Reversibility of lung inflammation caused by SP-B deficiency.
American journal of physiology. Lung cellular and molecular physiology 2005;289(6):L962-70.
2005: Kallapur Suhas G; Moss Timothy J M; Ikegami Machiko; Jasman Richard L; Newnham John P; Jobe Alan H
Recruited inflammatory cells mediate endotoxin-induced lung maturation in preterm fetal lambs.
American journal of respiratory and critical care medicine 2005;172(10):1315-21.
2005: Newnham John P; Shub Alexis; Jobe Alan H; Bird Philip S; Ikegami Machiko; Nitsos Ilias; Moss Timothy J M
The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep.
American journal of obstetrics and gynecology 2005;193(2):313-21.
2005: Ikegami Machiko; Le Cras Timothy D; Hardie William D; Stahlman Mildred T; Whitsett Jeffrey A; Korfhagen Thomas R
TGF-alpha perturbs surfactant homeostasis in vivo.
American journal of physiology. Lung cellular and molecular physiology 2005;289(1):L34-43.
2005: Nesslein Lori L; Melton Kristin R; Ikegami Machiko; Na Cheng-Lun; Wert Susan E; Rice Ward R; Whitsett Jeffrey A; Weaver Timothy E
Partial SP-B deficiency perturbs lung function and causes air space abnormalities.
American journal of physiology. Lung cellular and molecular physiology 2005;288(6):L1154-61.
2005: Kallapur Suhas G; Nitsos Ilias; Moss Timothy J M; Kramer Boris W; Newnham John P; Ikegami Machiko; Jobe Alan H
Chronic endotoxin exposure does not cause sustained structural abnormalities in the fetal sheep lungs.
American journal of physiology. Lung cellular and molecular physiology 2005;288(5):L966-74.
2005: Moss Timothy J M; Nitsos Ilias; Ikegami Machiko; Jobe Alan H; Newnham John P
Experimental intrauterine Ureaplasma infection in sheep.
American journal of obstetrics and gynecology 2005;192(4):1179-86.
2005: Ikegami Machiko; Na Cheng-Lun; Korfhagen Thomas R; Whitsett Jeffrey A
Surfactant protein D influences surfactant ultrastructure and uptake by alveolar type II cells.
American journal of physiology. Lung cellular and molecular physiology 2005;288(3):L552-61.
2005: Mulrooney Neil; Champion Zahra; Moss Timothy J M; Nitsos Ilias; Ikegami Machiko; Jobe Alan H
Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure.
American journal of respiratory and critical care medicine 2005;171(5):488-93.
2005: Ryan Marnie A; Qi Xiaoyang; Serrano Alicia G; Ikegami Machiko; Perez-Gil Jesus; Johansson Jan; Weaver Timothy E
Mapping and analysis of the lytic and fusogenic domains of surfactant protein B.
Biochemistry 2005;44(3):861-72.
2004: Kallapur Suhas G; Bachurski Cindy J; Le Cras Timothy D; Joshi Shubhada N; Ikegami Machiko; Jobe Alan H
Vascular changes after intra-amniotic endotoxin in preterm lamb lungs.
American journal of physiology. Lung cellular and molecular physiology 2004;287(6):L1178-85.
2004: Pillow J Jane; Jobe Alan H; Collins Rachel A; Hantos Zoltán; Ikegami Machiko; Moss Timothy J M; Newnham John P; Willet Karen E; Sly Peter D
Variability in preterm lamb lung mechanics after intra-amniotic endotoxin is associated with changes in surfactant pool size and morphometry.
American journal of physiology. Lung cellular and molecular physiology 2004;287(5):L992-8.
2004: Wan Huajing; Xu Yan; Ikegami Machiko; Stahlman Mildred T; Kaestner Klaus H; Ang Siew-Lan; Whitsett Jeffrey A
Foxa2 is required for transition to air breathing at birth.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(40):14449-54.
2004: Le Cras T D; Hardie W D; Deutsch G H; Albertine K H; Ikegami M; Whitsett J A; Korfhagen T R
Transient induction of TGF-alpha disrupts lung morphogenesis, causing pulmonary disease in adulthood.
American journal of physiology. Lung cellular and molecular physiology 2004;287(4):L718-29.
2004: Li Jing; Ikegami Machiko; Na Cheng-Lun; Hamvas Aaron; Espinassous Quentin; Chaby Richard; Nogee Lawrence M; Weaver Timothy E; Johansson Jan
N-terminally extended surfactant protein (SP) C isolated from SP-B-deficient children has reduced surface activity and inhibited lipopolysaccharide binding.
Biochemistry 2004;43(13):3891-8.
2004: Mulrooney Neil; Jobe Alan H; Ikegami Machiko
Lung inflammatory responses to intratracheal interleukin-1alpha in ventilated preterm lambs.
Pediatric research 2004;55(4):682-7.
2004: Ikegami Machiko; Kallapur Suhas G; Jobe Alan H
Initial responses to ventilation of premature lambs exposed to intra-amniotic endotoxin 4 days before delivery.
American journal of physiology. Lung cellular and molecular physiology 2004;286(3):L573-9.
2004: Wan Huajing; Kaestner Klaus H; Ang Siew-Lan; Ikegami Machiko; Finkelman Fred D; Stahlman Mildred T; Fulkerson Patricia C; Rothenberg Marc E; Whitsett Jeffrey A
Foxa2 regulates alveolarization and goblet cell hyperplasia.
Development (Cambridge, England) 2004;131(4):953-64.
2004: Hokuto Isamu; Ikegami Machiko; Yoshida Mitsuhiro; Takeda Kiyoshi; Akira Shizuo; Perl Anne-Karina T; Hull William M; Wert Susan E; Whitsett Jeffrey A
Stat-3 is required for pulmonary homeostasis during hyperoxia.
The Journal of clinical investigation 2004;113(1):28-37.
2003: Moss Timothy J M; Nitsos Ilias; Newnham John P; Ikegami Machiko; Jobe Alan H
Chorioamnionitis induced by subchorionic endotoxin infusion in sheep.
American journal of obstetrics and gynecology 2003;189(6):1771-6.
2003: Liu Cong; Ikegami Machiko; Stahlman Mildred T; Dey Chitta R; Whitsett Jeffrey A
Inhibition of alveolarization and altered pulmonary mechanics in mice expressing GATA-6.
American journal of physiology. Lung cellular and molecular physiology 2003;285(6):L1246-54.
2003: Newnham John P; Kallapur Suhas G; Kramer Boris W; Moss Timothy J M; Nitsos Ilias; Ikegami Machiko; Jobe Alan H
Betamethasone effects on chorioamnionitis induced by intra-amniotic endotoxin in sheep.
American journal of obstetrics and gynecology 2003;189(5):1458-66.
2003: Moss Timothy J m; Mulrooney Neil P; Nitsos Ilias; Ikegami Machiko; Jobe Alan H; Newnham John P
Intra-amniotic corticosteroids for preterm lung maturation in sheep.
American journal of obstetrics and gynecology 2003;189(5):1389-95.
2003: Melton Kristin R; Nesslein Lori L; Ikegami Machiko; Tichelaar Jay W; Clark Jean C; Whitsett Jeffrey A; Weaver Timothy E
SP-B deficiency causes respiratory failure in adult mice.
American journal of physiology. Lung cellular and molecular physiology 2003;285(3):L543-9.
2003: Kramer Boris W; Jobe Alan H; Ikegami Machiko
Monocyte function in preterm, term, and adult sheep.
Pediatric research 2003;54(1):52-7.
2003: Ikegami Machiko; Moss Timothy J M; Kallapur Suhas G; Mulrooney Neil; Kramer Boris W; Nitsos Ilias; Bachurski Cindy J; Newnham John P; Jobe Alan H
Minimal lung and systemic responses to TNF-alpha in preterm sheep.
American journal of physiology. Lung cellular and molecular physiology 2003;285(1):L121-9.
2003: Glasser Stephan W; Detmer Emily A; Ikegami Machiko; Na Cheng-Lun; Stahlman Mildred T; Whitsett Jeffrey A
Pneumonitis and emphysema in sp-C gene targeted mice.
The Journal of biological chemistry 2003;278(16):14291-8.
2003: Kallapur Suhas G; Kramer Boris W; Moss Timothy J M; Newnham John P; Jobe Alan H; Ikegami Machiko; Bachurski Cindy J
Maternal glucocorticoids increase endotoxin-induced lung inflammation in preterm lambs.
American journal of physiology. Lung cellular and molecular physiology 2003;284(4):L633-42.
2003: Kallapur Suhas G; Jobe Alan H; Ikegami Machiko; Bachurski Cindy J
Increased IP-10 and MIG expression after intra-amniotic endotoxin in preterm lamb lung.
American journal of respiratory and critical care medicine 2003;167(5):779-86.
2003: Strand Marya; Ikegami Machiko; Jobe Alan H
Effects of high PCO2 on ventilated preterm lamb lungs.
Pediatric research 2003;53(3):468-72.
2003: Collins Rachel A; Ikegami Machiko; Korfhagen Thomas R; Whitsett Jeffrey A; Sly Peter D
In vivo measurements of changes in respiratory mechanics with age in mice deficient in surfactant protein D.
Pediatric research 2003;53(3):463-7.
2003: Epaud Ralph; Ikegami Machiko; Whitsett Jeffrey A; Jobe Alan H; Weaver Timothy E; Akinbi Henry T
Surfactant protein B inhibits endotoxin-induced lung inflammation.
American journal of respiratory cell and molecular biology 2003;28(3):373-8.
2003: Ikegami Machiko; Dhami Rajwinder; Schuchman Edward H
Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease.
American journal of physiology. Lung cellular and molecular physiology 2003;284(3):L518-25.
2003: Smith Lynne M; Ervin M Gore; Wada Norihisa; Ikegami Machiko; Jobe Alan H
Single and multiple prenatal glucocorticoid exposures improve preterm newborn lamb cardiovascular and renal function similarly.
American journal of obstetrics and gynecology 2003;188(2):444-53.
2003: Jobe Alan H; Newnham John P; Moss Timothy J; Ikegami Machiko
Differential effects of maternal betamethasone and cortisol on lung maturation and growth in fetal sheep.
American journal of obstetrics and gynecology 2003;188(1):22-8.
2002: Moss Timothy J M; Nitsos Ilias; Kramer Boris W; Ikegami Machiko; Newnham John P; Jobe Alan H
Intra-amniotic endotoxin induces lung maturation by direct effects on the developing respiratory tract in preterm sheep.
American journal of obstetrics and gynecology 2002;187(4):1059-65.
2002: Zhang Liqian; Ikegami Machiko; Dey Chitta R; Korfhagen Thomas R; Whitsett Jeffrey A
Reversibility of pulmonary abnormalities by conditional replacement of surfactant protein D (SP-D) in vivo.
The Journal of biological chemistry 2002;277(41):38709-13.
2002: Jobe Alan H; Kramer Boris W; Moss Timothy J; Newnham John P; Ikegami Machiko
Decreased indicators of lung injury with continuous positive expiratory pressure in preterm lambs.
Pediatric research 2002;52(3):387-92.
2002: Ikegami Machiko; Jobe Alan H
Postnatal lung inflammation increased by ventilation of preterm lambs exposed antenatally to Escherichia coli endotoxin.
Pediatric research 2002;52(3):356-62.
2002: Ikegami Machiko; Takabatake Noriaki; Weaver Timothy E
Intersubunit disulfide bridge is not required for the protective role of SP-B against lung inflammation.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(2):505-11.
2002: Kramer Boris W; Kramer Susanne; Ikegami Machiko; Jobe Alan H
Injury, inflammation, and remodeling in fetal sheep lung after intra-amniotic endotoxin.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L452-9.
2002: Rice Ward R; Conkright Juliana J; Na Cheng-Lun; Ikegami Machiko; Shannon John M; Weaver Timothy E
Maintenance of the mouse type II cell phenotype in vitro.
American journal of physiology. Lung cellular and molecular physiology 2002;283(2):L256-64.
2002: Palaniyar Nades; Zhang Liquian; Kuzmenko Alexander; Ikegami Machiko; Wan Sijue; Wu Huixing; Korfhagen Thomas R; Whitsett Jeffrey A; McCormack Francis X
The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo.
The Journal of biological chemistry 2002;277(30):26971-9.
2002: Ikegami Machiko; Jobe Alan H
Injury responses to different surfactants in ventilated premature lamb lungs.
Pediatric research 2002;51(6):689-95.
2002: Zhang Liqian; Hartshorn Kevan L; Crouch Erika C; Ikegami Machiko; Whitsett Jeffrey A
Complementation of pulmonary abnormalities in SP-D(-/-) mice with an SP-D/conglutinin fusion protein.
The Journal of biological chemistry 2002;277(25):22453-9.
2002: Newnham John P; Moss Timothy J M; Kramer Boris W; Nitsos Ilias; Ikegami Machiko; Jobe Alan H
The fetal maturational and inflammatory responses to different routes of endotoxin infusion in sheep.
American journal of obstetrics and gynecology 2002;186(5):1062-8.
2002: Moss Timothy J M; Newnham John P; Willett Karen E; Kramer Boris W; Jobe Alan H; Ikegami Machiko
Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry.
American journal of respiratory and critical care medicine 2002;165(6):805-11.
2002: Willet Karen E; Kramer Boris W; Kallapur Suhas G; Ikegami Machiko; Newnham John P; Moss Timothy J; Sly Peter D; Jobe Alan H
Intra-amniotic injection of IL-1 induces inflammation and maturation in fetal sheep lung.
American journal of physiology. Lung cellular and molecular physiology 2002;282(3):L411-20.
2002: Kramer Boris W; Ikegami Machiko; Jobe Alan H
Intratracheal endotoxin causes systemic inflammation in ventilated preterm lambs.
American journal of respiratory and critical care medicine 2002;165(4):463-9.
2002: Ikegami Machiko; Weaver Timothy E; Conkright Juliana J; Sly Peter D; Ross Gary F; Whitsett Jeffrey A; Glasser Stephan W
Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;92(2):519-26.
2001: Hardie W D; Piljan-Gentle A; Dunlavy M R; Ikegami M; Korfhagen T R
Dose-dependent lung remodeling in transgenic mice expressing transforming growth factor-alpha.
American journal of physiology. Lung cellular and molecular physiology 2001;281(5):L1088-94.
2001: Ikegami M; Elhalwagi B M; Palaniyar N; Dienger K; Korfhagen T; Whitsett J A; McCormack F X
The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse.
The Journal of biological chemistry 2001;276(42):38542-8.
2001: Kramer B W; Moss T J; Willet K E; Newnham J P; Sly P D; Kallapur S G; Ikegami M; Jobe A H
Dose and time response after intraamniotic endotoxin in preterm lambs.
American journal of respiratory and critical care medicine 2001;164(6):982-8.
2001: Jobe A H; Ikegami M
Biology of surfactant.
Clinics in perinatology 2001;28(3):655-69, vii-viii.
2001: Ikegami M; Hull W M; Yoshida M; Wert S E; Whitsett J A
SP-D and GM-CSF regulate surfactant homeostasis via distinct mechanisms.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L697-703.
2001: Naik A S; Kallapur S G; Bachurski C J; Jobe A H; Michna J; Kramer B W; Ikegami M
Effects of ventilation with different positive end-expiratory pressures on cytokine expression in the preterm lamb lung.
American journal of respiratory and critical care medicine 2001;164(3):494-8.
2001: Newnham J P; Moss T J; Padbury J F; Willet K E; Ikegami M; Ervin M G; Sly P; Jobe A
The interactive effects of endotoxin with prenatal glucocorticoids on short-term lung function in sheep.
American journal of obstetrics and gynecology 2001;185(1):190-7.
2001: Gurel O; Ikegami M; Chroneos Z C; Jobe A H
Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(6):L1266-72.
2001: Zhang L; Ikegami M; Crouch E C; Korfhagen T R; Whitsett J A
Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure.
The Journal of biological chemistry 2001;276(22):19214-9.
2001: Willet K E; Jobe A H; Ikegami M; Kovar J; Sly P D
Lung morphometry after repetitive antenatal glucocorticoid treatment in preterm sheep.
American journal of respiratory and critical care medicine 2001;163(6):1437-43.
2001: Glasser S W; Burhans M S; Korfhagen T R; Na C L; Sly P D; Ross G F; Ikegami M; Whitsett J A
Altered stability of pulmonary surfactant in SP-C-deficient mice.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6366-71.
2001: Jobe A H; Ikegami M
Prevention of bronchopulmonary dysplasia.
Current opinion in pediatrics 2001;13(2):124-9.
2001: Kramer B W; Jobe A H; Ikegami M
Exogenous surfactant changes the phenotype of alveolar macrophages in mice.
American journal of physiology. Lung cellular and molecular physiology 2001;280(4):L689-94.
2001: Kallapur S G; Willet K E; Jobe A H; Ikegami M; Bachurski C J
Intra-amniotic endotoxin: chorioamnionitis precedes lung maturation in preterm lambs.
American journal of physiology. Lung cellular and molecular physiology 2001;280(3):L527-36.
2001: Yoshida M; Ikegami M; Reed J A; Chroneos Z C; Whitsett J A
GM-CSF regulates protein and lipid catabolism by alveolar macrophages.
American journal of physiology. Lung cellular and molecular physiology 2001;280(3):L379-86.
2001: Bachurski C J; Ross G F; Ikegami M; Kramer B W; Jobe A H
Intra-amniotic endotoxin increases pulmonary surfactant proteins and induces SP-B processing in fetal sheep.
American journal of physiology. Lung cellular and molecular physiology 2001;280(2):L279-85.
2001: Kramer B W; Jobe A H; Bachurski C J; Ikegami M
Surfactant protein A recruits neutrophils into the lungs of ventilated preterm lambs.
American journal of respiratory and critical care medicine 2001;163(1):158-65.
2001: Jobe A H; Ikegami M
Antenatal infection/inflammation and postnatal lung maturation and injury.
Respiratory research 2001;2(1):27-32.
2000: Willet K E; Jobe A H; Ikegami M; Newnham J; Brennan S; Sly P D
Antenatal endotoxin and glucocorticoid effects on lung morphometry in preterm lambs.
Pediatric research 2000;48(6):782-8.
2000: Jobe A H; Newnham J P; Willet K E; Moss T J; Gore Ervin M; Padbury J F; Sly P; Ikegami M
Endotoxin-induced lung maturation in preterm lambs is not mediated by cortisol.
American journal of respiratory and critical care medicine 2000;162(5):1656-61.
2000: Kramer B W; Ikegami M; Jobe A H
Surfactant phospholipid catabolic rate is pool size dependent in mice.
American journal of physiology. Lung cellular and molecular physiology 2000;279(5):L842-8.
2000: Bhat V; Jobe A H; Wert S; Jesmok G J; Ikegami M
Plasminogen did not affect lung function in surfactant-treated preterm lambs.
Biology of the neonate 2000;78(3):212-9.
2000: Willet K E; Jobe A H; Ikegami M; Newnham J; Sly P D
Pulmonary interstitial emphysema 24 hours after antenatal betamethasone treatment in preterm sheep.
American journal of respiratory and critical care medicine 2000;162(3 Pt 1):1087-94.
2000: Ikegami M; Whitsett J A; Jobe A; Ross G; Fisher J; Korfhagen T
Surfactant metabolism in SP-D gene-targeted mice.
American journal of physiology. Lung cellular and molecular physiology 2000;279(3):L468-76.
2000: Ervin M G; Padbury J F; Polk D H; Ikegami M; Berry L M; Jobe A H
Antenatal glucocorticoids alter premature newborn lamb neuroendocrine and endocrine responses to hypoxia.
American journal of physiology. Regulatory, integrative and comparative physiology 2000;279(3):R830-8.
2000: Ikegami M; Jobe A H; Whitsett J; Korfhagen T
Tolerance of SP-A-deficient mice to hyperoxia or exercise.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(2):644-8.
2000: Willet K E; Jobe A H; Ikegami M; Newnham J; Sly P D
Antenatal retinoic acid does not alter alveolization or postnatal lung function in preterm sheep.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2000;16(1):101-7.
2000: Reed J A; Ikegami M; Robb L; Begley C G; Ross G; Whitsett J A
Distinct changes in pulmonary surfactant homeostasis in common beta-chain- and GM-CSF-deficient mice.
American journal of physiology. Lung cellular and molecular physiology 2000;278(6):L1164-71.
2000: Pinkerton K E; Ikegami M; Dillard L M; Jobe A H
Surfactant treatment effects on lung structure and type II cells of preterm ventilated lambs.
Biology of the neonate 2000;77(4):243-52.
2000: Smith L M; Ervin M G; Wada N; Ikegami M; Polk D H; Jobe A H
Antenatal glucocorticoids alter postnatal preterm lamb renal and cardiovascular responses to intravascular volume expansion.
Pediatric research 2000;47(5):622-7.
2000: Wert S E; Yoshida M; LeVine A M; Ikegami M; Jones T; Ross G F; Fisher J H; Korfhagen T R; Whitsett J A
Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(11):5972-7.
2000: Ikegami M; Kallapur S; Michna J; Jobe A H
Lung injury and surfactant metabolism after hyperventilation of premature lambs.
Pediatric research 2000;47(3):398-404.
2000: Jobe A H; Newnham J P; Willet K E; Sly P; Ervin M G; Bachurski C; Possmayer F; Hallman M; Ikegami M
Effects of antenatal endotoxin and glucocorticoids on the lungs of preterm lambs.
American journal of obstetrics and gynecology 2000;182(2):401-8.
2000: Fisher J H; Sheftelyevich V; Ho Y S; Fligiel S; McCormack F X; Korfhagen T R; Whitsett J A; Ikegami M
Pulmonary-specific expression of SP-D corrects pulmonary lipid accumulation in SP-D gene-targeted mice.
American journal of physiology. Lung cellular and molecular physiology 2000;278(2):L365-73.
2000: Beck D C; Ikegami M; Na C L; Zaltash S; Johansson J; Whitsett J A; Weaver T E
The role of homodimers in surfactant protein B function in vivo.
The Journal of biological chemistry 2000;275(5):3365-70.
2000: Ikegami M; Whitsett J A; Chroneos Z C; Ross G F; Reed J A; Bachurski C J; Jobe A H
IL-4 increases surfactant and regulates metabolism in vivo.
American journal of physiology. Lung cellular and molecular physiology 2000;278(1):L75-80.
2000: Kallapur S; Ikegami M
The surfactants.
American journal of perinatology 2000;17(7):335-43.
2000: Jobe A H; Ikegami M
Lung development and function in preterm infants in the surfactant treatment era.
Annual review of physiology 2000;62():825-46.
1999: Ross G F; Ikegami M; Steinhilber W; Jobe A H
Surfactant protein C in fetal and ventilated preterm rabbit lungs.
The American journal of physiology 1999;277(6 Pt 1):L1104-8.
1999: Tokieda K; Ikegami M; Wert S E; Baatz J E; Zou Y; Whitsett J A
Surfactant protein B corrects oxygen-induced pulmonary dysfunction in heterozygous surfactant protein B-deficient mice.
Pediatric research 1999;46(6):708-14.
1999: Ikegami M; Harrod K S; Whitsett J A; Jobe A H
CCSP deficiency does not alter surfactant homeostasis during adenoviral infection.
The American journal of physiology 1999;277(5 Pt 1):L983-7.
1999: Elhalwagi B M; Zhang M; Ikegami M; Iwamoto H S; Morris R E; Miller M L; Dienger K; McCormack F X
Normal surfactant pool sizes and inhibition-resistant surfactant from mice that overexpress surfactant protein A.
American journal of respiratory cell and molecular biology 1999;21(3):380-7.
1999: Edwards J E; Newnham J; Ikegami M; Polk D; Jobe A
Beta-methasone increases sweat gland formation and suppresses fibre formation in fetal sheep.
Experimental dermatology 1999;8(4):349-50.
1999: Michna J; Jobe A H; Ikegami M
Positive end-expiratory pressure preserves surfactant function in preterm lambs.
American journal of respiratory and critical care medicine 1999;160(2):634-9.
1999: Girod C E; Shin D H; Geraci M W; Warren H B; Dobbs L G; Gao B; Rainer J S; Bauer A K; Ikegami M; Shannon J M; Miller Y E
Surfactant protein C promoter-driven expression of T1-alpha induces lung inflammation.
Chest 1999;116(1 Suppl):61S.
1999: Newnham J P; Evans S F; Godfrey M; Huang W; Ikegami M; Jobe A
Maternal, but not fetal, administration of corticosteroids restricts fetal growth.
The Journal of maternal-fetal medicine 1999;8(3):81-7.
1999: Willet K E; McMenamin P; Pinkerton K E; Ikegami M; Jobe A H; Gurrin L; Sly P D
Lung morphometry and collagen and elastin content: changes during normal development and after prenatal hormone exposure in sheep.
Pediatric research 1999;45(5 Pt 1):615-25.
1999: Reed J A; Ikegami M; Cianciolo E R; Lu W; Cho P S; Hull W; Jobe A H; Whitsett J A
Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice.
The American journal of physiology 1999;276(4 Pt 1):L556-63.
1999: Smith L M; Ikegami M; Calvario G C; Surdilla J; Ervin M G
Renal responses to angiotensin II receptor blockade in ventilated preterm newborn lambs.
Reproduction, fertility, and development 1999;11(7-8):419-24.
1998: Ikegami M; Jobe A H
Surfactant protein-C in ventilated premature lamb lung.
Pediatric research 1998;44(6):860-4.
1998: Jobe A H; Ikegami M
Mechanisms initiating lung injury in the preterm.
Early human development 1998;53(1):81-94.
1998: Jobe A H; Ikegami M
Surfactant and acute lung injury.
Proceedings of the Association of American Physicians 1998;110(6):489-95.
1998: Ikegami M; Jobe A H
Surfactant protein metabolism in vivo.
Biochimica et biophysica acta 1998;1408(2-3):218-25.
1998: Jobe A H; Newnham J; Willet K; Sly P; Ikegami M
Fetal versus maternal and gestational age effects of repetitive antenatal glucocorticoids.
Pediatrics 1998;102(5):1116-25.
1998: Korfhagen T R; Sheftelyevich V; Burhans M S; Bruno M D; Ross G F; Wert S E; Stahlman M T; Jobe A H; Ikegami M; Whitsett J A; Fisher J H
Surfactant protein-D regulates surfactant phospholipid homeostasis in vivo.
The Journal of biological chemistry 1998;273(43):28438-43.
1998: Jobe A H; Ikegami M
Surfactant homeostasis in corticotropin-releasing hormone deficiency in adult mice.
American journal of respiratory and critical care medicine 1998;158(3):995-7.
1998: Wada N; Ervin M G; Ikegami M
Effect of ventilation style on cardiovascular and renal adaptation in preterm newborn lambs.
The American journal of physiology 1998;275(3 Pt 2):R836-43.
1998: Ikegami M; Korfhagen T R; Whitsett J A; Bruno M D; Wert S E; Wada K; Jobe A H
Characteristics of surfactant from SP-A-deficient mice.
The American journal of physiology 1998;275(2 Pt 1):L247-54.
1998: Ikegami M; Horowitz A D; Whitsett J A; Jobe A H
Clearance of SP-C and recombinant SP-C in vivo and in vitro.
The American journal of physiology 1998;274(6 Pt 1):L933-9.
1998: Jobe A H; Wada N; Berry L M; Ikegami M; Ervin M G
Single and repetitive maternal glucocorticoid exposures reduce fetal growth in sheep.
American journal of obstetrics and gynecology 1998;178(5):880-5.
1998: Ervin M G; Seidner S R; Leland M M; Ikegami M; Jobe A H
Direct fetal glucocorticoid treatment alters postnatal adaptation in premature newborn baboons.
The American journal of physiology 1998;274(4 Pt 2):R1169-76.
1997: Willet K E; Jobe A H; Ikegami M; Polk D; Newnham J; Kohan R; Gurrin L; Sly P D
Postnatal lung function after prenatal steroid treatment in sheep: effect of gender.
Pediatric research 1997;42(6):885-92.
1997: Tokieda K; Whitsett J A; Clark J C; Weaver T E; Ikeda K; McConnell K B; Jobe A H; Ikegami M; Iwamoto H S
Pulmonary dysfunction in neonatal SP-B-deficient mice.
The American journal of physiology 1997;273(4 Pt 1):L875-82.
1997: Ikegami M; Jobe A H; Huffman Reed J A; Whitsett J A
Surfactant metabolic consequences of overexpression of GM-CSF in the epithelium of GM-CSF-deficient mice.
The American journal of physiology 1997;273(4 Pt 1):L709-14.
1997: Pinkerton K E; Willet K E; Peake J L; Sly P D; Jobe A H; Ikegami M
Prenatal glucocorticoid and T4 effects on lung morphology in preterm lambs.
American journal of respiratory and critical care medicine 1997;156(2 Pt 1):624-30.
1997: Horowitz A D; Kurak K; Moussavian B; Whitsett J A; Wert S E; Hull W M; McNanie J; Ikegami M
Preferential uptake of small-aggregate fraction of pulmonary surfactant in vitro.
The American journal of physiology 1997;273(2 Pt 1):L468-77.
1997: Ikegami M; Jobe A H; Newnham J; Polk D H; Willet K E; Sly P
Repetitive prenatal glucocorticoids improve lung function and decrease growth in preterm lambs.
American journal of respiratory and critical care medicine 1997;156(1):178-84.
1997: Rebello C M; Ikegami M; Ervin M G; Polk D H; Jobe A H
Postnatal lung function and protein permeability after fetal or maternal corticosteroids in preterm lambs.
Journal of applied physiology (Bethesda, Md. : 1985) 1997;83(1):213-8.
1997: Berry L M; Polk D H; Ikegami M; Jobe A H; Padbury J F; Ervin M G
Preterm newborn lamb renal and cardiovascular responses after fetal or maternal antenatal betamethasone.
The American journal of physiology 1997;272(6 Pt 2):R1972-9.
1997: Akinbi H T; Breslin J S; Ikegami M; Iwamoto H S; Clark J C; Whitsett J A; Jobe A H; Weaver T E
Rescue of SP-B knockout mice with a truncated SP-B proprotein. Function of the C-terminal propeptide.
The Journal of biological chemistry 1997;272(15):9640-7.
1997: Ikegami M; Korfhagen T R; Bruno M D; Whitsett J A; Jobe A H
Surfactant metabolism in surfactant protein A-deficient mice.
The American journal of physiology 1997;272(3 Pt 1):L479-85.
1997: Polk D H; Ikegami M; Jobe A H; Sly P; Kohan R; Newnham J
Preterm lung function after retreatment with antenatal betamethasone in preterm lambs.
American journal of obstetrics and gynecology 1997;176(2):308-15.
1997: Clark J C; Weaver T E; Iwamoto H S; Ikegami M; Jobe A H; Hull W M; Whitsett J A
Decreased lung compliance and air trapping in heterozygous SP-B-deficient mice.
American journal of respiratory cell and molecular biology 1997;16(1):46-52.
1997: Emerson G A; Bry K; Hallman M; Jobe A H; Wada N; Ervin M G; Ikegami M
Intra-amniotic interleukin-1 alpha treatment alters postnatal adaptation in premature lambs.
Biology of the neonate 1997;72(6):370-9.
1997: Jobe A H; Ikegami M; Padbury J; Polk D H; Korirnilli A; Gonzales L W; Ballard P L
Combined effects of fetal beta agonist stimulation and glucocorticoids on lung function of preterm lambs.
Biology of the neonate 1997;72(5):305-13.

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