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Yukio Ikehara

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Miwa Sohda; Yoshio Misumi; Shin-Ichiro Yoshimura; Nobuhiro Nakamura; Takami Fusano; Shigenori Ogata; Shotaro Sakisaka; Yukio Ikehara
The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.
Norihisa Suzuki; Makoto Irie; Kaoru Iwata; Hidetoshi Nakane; Makoto Yoshikane; Yasuhiro Koyama; Yuko Uehara; Yasuaki Takeyama; Yuji Kitamura; Tetsuro Sohda; Hiroshi Watanabe; Yukio Ikehara; Shotaro Sakisaka
Altered expression of alkaline phosphatase (ALP) in the liver of primary biliary cirrhosis (PBC) patients.
Miwa Sohda; Yoshio Misumi; Shin-ichiro Yoshimura; Nobuhiro Nakamura; Takami Fusano; Shotaro Sakisaka; Shigenori Ogata; Junichro Fujimoto; Nobutaka Kiyokawa; Yukio Ikehara
Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport.

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All Publications

2007: Miwa Sohda; Yoshio Misumi; Shin-Ichiro Yoshimura; Nobuhiro Nakamura; Takami Fusano; Shigenori Ogata; Shotaro Sakisaka; Yukio Ikehara
The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity.
Traffic (Copenhagen, Denmark) 2007;8(3):270-84.
2006: Norihisa Suzuki; Makoto Irie; Kaoru Iwata; Hidetoshi Nakane; Makoto Yoshikane; Yasuhiro Koyama; Yuko Uehara; Yasuaki Takeyama; Yuji Kitamura; Tetsuro Sohda; Hiroshi Watanabe; Yukio Ikehara; Shotaro Sakisaka
Altered expression of alkaline phosphatase (ALP) in the liver of primary biliary cirrhosis (PBC) patients.
Hepatology research : the official journal of the Japan Society of Hepatology 2006;35(1):37-44.
2005: Miwa Sohda; Yoshio Misumi; Shin-ichiro Yoshimura; Nobuhiro Nakamura; Takami Fusano; Shotaro Sakisaka; Shigenori Ogata; Junichro Fujimoto; Nobutaka Kiyokawa; Yukio Ikehara
Depletion of vesicle-tethering factor p115 causes mini-stacked Golgi fragments with delayed protein transport.
Biochemical and biophysical research communications 2005;338(2):1268-74.
2003: Eiji Ohta; Yoshio Misumi; Miwa Sohda; Toshiyuki Fujiwara; Akiko Yano; Yukio Ikehara
Identification and characterization of GCP16, a novel acylated Golgi protein that interacts with GCP170.
The Journal of biological chemistry 2003;278(51):51957-67.
2003: Yoshio Misumi; Yukio Ikehara
[Biogenesis and regulation of the Golgi complex].
Seikagaku. The Journal of Japanese Biochemical Society 2003;75(6):479-85.
2003: Toshiyuki Fujiwara; Yoshio Misumi; Yukio Ikehara
Direct interaction of the Golgi membrane with the endoplasmic reticulum membrane caused by nordihydroguaiaretic acid.
Biochemical and biophysical research communications 2003;301(4):927-33.
2003: Kumiko Ohkubo; Yuko Naito; Toshiyuki Fujiwara; Jun-ichi Miyazaki; Yukio Ikehara; Junko Ono
Inhibitory effect of the alpha1-antitrypsin Pittsburgh type-mutant (alpha1-PIM/R) on proinsulin processing in the regulated secretory pathway of the pancreatic beta-cell line MIN6.
Endocrine journal 2003;50(1):9-20.
2001: Miwa Sohda; Yoshio Misumi; A Yamamoto; Akiko Yano; Nobuhiro Nakamura; Yukio Ikehara
Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin.
The Journal of biological chemistry 2001;276(48):45298-306.
2001: Yoshio Misumi; Miwa Sohda; A Tashiro; H Sato; Yukio Ikehara
An essential cytoplasmic domain for the Golgi localization of coiled-coil proteins with a COOH-terminal membrane anchor.
The Journal of biological chemistry 2001;276(9):6867-73.
2001: Yoshiaki Kin; Yoshio Misumi; Yukio Ikehara
Biosynthesis and characterization of the brain-specific membrane protein DPPX, a dipeptidyl peptidase IV-related protein.
Journal of biochemistry 2001;129(2):289-95.
1999: Hiroshi Tsujioka; N Takami; Yoshio Misumi; Yukio Ikehara
Intracellular cleavage of glycosylphosphatidylinositol by phospholipase D induces activation of protein kinase Calpha.
The Biochemical journal 1999;342 ( Pt 2)():449-55.
1998: Toshiyuki Fujiwara; Yoshio Misumi; Yukio Ikehara
Dynamic recycling of ERGIC53 between the endoplasmic reticulum and the Golgi complex is disrupted by nordihydroguaiaretic acid.
Biochemical and biophysical research communications 1998;253(3):869-76.
1998: Hiroshi Tsujioka; Yoshio Misumi; N Takami; Yukio Ikehara; H Tujioka
Posttranslational modification of glycosylphosphatidylinositol (GPI)-specific phospholipase D and its activity in cleavage of GPI anchors.
Biochemical and biophysical research communications 1998;251(3):737-43.
1998: H Shibata; M Fukushi; A Igarashi; Yoshio Misumi; Yukio Ikehara; Y Ohashi; K Oda
Defective intracellular transport of tissue-nonspecific alkaline phosphatase with an Ala162-->Thr mutation associated with lethal hypophosphatasia.
Journal of biochemistry 1998;123(5):968-77.
1998: Miwa Sohda; Yoshio Misumi; Akiko Yano; N Takami; Yukio Ikehara
Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane.
The Journal of biological chemistry 1998;273(9):5385-8.
1998: Toshiyuki Fujiwara; N Takami; Yoshio Misumi; Yukio Ikehara
Nordihydroguaiaretic acid blocks protein transport in the secretory pathway causing redistribution of Golgi proteins into the endoplasmic reticulum.
The Journal of biological chemistry 1998;273(5):3068-75.
1997: C Toki; Toshiyuki Fujiwara; Miwa Sohda; H S Hong; Yoshio Misumi; Yukio Ikehara
Identification and characterization of rat 364-kDa Golgi-associated protein recognized by autoantibodies from a patient with rheumatoid arthritis.
Cell structure and function 1997;22(5):565-77.
1997: Yoshio Misumi; Miwa Sohda; Akiko Yano; Toshiyuki Fujiwara; Yukio Ikehara
Molecular characterization of GCP170, a 170-kDa protein associated with the cytoplasmic face of the Golgi membrane.
The Journal of biological chemistry 1997;272(38):23851-8.
1997: T Haruta; N Takami; M Ohmura; Yoshio Misumi; Yukio Ikehara
Ca2+-dependent interaction of the growth-associated protein GAP-43 with the synaptic core complex.
The Biochemical journal 1997;325 ( Pt 2)():455-63.
1996: K Oda; I Wada; N Takami; T Fujiwara; Yoshio Misumi; Yukio Ikehara
Bip/GRP78 but not calnexin associates with a precursor of glycosylphosphatidylinositol-anchored protein.
The Biochemical journal 1996;316 ( Pt 2)():623-30.
1996: K Oda; Yukio Ikehara; S Omura
Lactacystin, an inhibitor of the proteasome, blocks the degradation of a mutant precursor of glycosylphosphatidylinositol-linked protein in a pre-Golgi compartment.
Biochemical and biophysical research communications 1996;219(3):800-5.
1996: T Funaki; Toshiyuki Fujiwara; H S Hong; Yoshio Misumi; M Nishioka; Yukio Ikehara
Identification and characterization of a 230-kDa Golgi-associated protein recognized by autoantibodies from a patient with HBV hepatitis.
Cell structure and function 1996;21(1):63-72.
1994: Miwa Sohda; Yoshio Misumi; Toshiyuki Fujiwara; M Nishioka; Yukio Ikehara
Molecular cloning and sequence analysis of a human 372-kDA protein localized in the Golgi complex.
Biochemical and biophysical research communications 1994;205(2):1399-408.
1994: K Oda; J Cheng; T Saku; N Takami; Miwa Sohda; Yoshio Misumi; Yukio Ikehara; J L Millán
Conversion of secretory proteins into membrane proteins by fusing with a glycosylphosphatidylinositol anchor signal of alkaline phosphatase.
The Biochemical journal 1994;301 ( Pt 2)():577-83.
1994: Yukio Ikehara; S Ogata; Yoshio Misumi
Dipeptidyl-peptidase IV from rat liver.
Methods in enzymology 1994;244():215-27.
1992: K Oda; Yoshio Misumi; Yukio Ikehara; Stephen O Brennan; K Hatsuzawa; K Nakayama
Proteolytic cleavages of proalbumin and complement Pro-C3 in vitro by a truncated soluble form of furin, a mammalian homologue of the yeast Kex2 protease.
Biochemical and biophysical research communications 1992;189(3):1353-61.
1992: E Tsuji; Yoshio Misumi; Toshiyuki Fujiwara; N Takami; S Ogata; Yukio Ikehara
An active-site mutation (Gly633-->Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum.
Biochemistry 1992;31(47):11921-7.
1992: Yoshio Misumi; Y Hayashi; Fumiko Arakawa; Yukio Ikehara
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface.
Biochimica et biophysica acta 1992;1131(3):333-6.
1992: Toshiyuki Fujiwara; E Tsuji; Yoshio Misumi; N Takami; Yukio Ikehara
Selective cell-surface expression of dipeptidyl peptidase IV with mutations at the active site sequence.
Biochemical and biophysical research communications 1992;185(2):776-84.
1992: S Ogata; Yoshio Misumi; E Tsuji; N Takami; K Oda; Yukio Ikehara
Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis.
Biochemistry 1992;31(9):2582-7.
1992: N Takami; K Oda; Yukio Ikehara
Aberrant processing of alkaline phosphatase precursor caused by blocking the synthesis of glycosylphosphatidylinositol.
The Journal of biological chemistry 1992;267(2):1042-7.
1991: K Oda; M Ikeda; E Tsuji; Miwa Sohda; N Takami; Yoshio Misumi; Yukio Ikehara
Sequence requirements for proteolytic cleavage of precursors with paired basic amino acids.
Biochemical and biophysical research communications 1991;179(3):1181-6.
1991: Yoshio Misumi; K Oda; Toshiyuki Fujiwara; N Takami; K Tashiro; Yukio Ikehara
Functional expression of furin demonstrating its intracellular localization and endoprotease activity for processing of proalbumin and complement pro-C3.
The Journal of biological chemistry 1991;266(25):16954-9.
1991: K Oda; Y Nishimura; Yukio Ikehara; K Kato
Bafilomycin A1 inhibits the targeting of lysosomal acid hydrolases in cultured hepatocytes.
Biochemical and biophysical research communications 1991;178(1):369-77.
1991: K Ohkubo; S Ogata; Yoshio Misumi; N Takami; H Sinohara; Yukio Ikehara
Cloning, structure and expression of cDNA for mouse contrapsin and a related protein.
The Biochemical journal 1991;276 ( Pt 2)():337-42.
1991: K Oda; Yoshio Misumi; Miwa Sohda; N Takami; Y Sakaki; Yukio Ikehara
Selective processing of proalbumin determined by site-specific mutagenesis.
Biochemical and biophysical research communications 1991;175(2):690-6.
1991: K Ohkubo; S Ogata; Yoshio Misumi; N Takami; Yukio Ikehara
Molecular cloning and characterization of rat contrapsin-like protease inhibitor and related proteins.
Journal of biochemistry 1991;109(2):243-50.
1991: Y Matsuoka; Y Matsuo; N Okamoto; Masahide Kuroki; M Kuroki; Yukio Ikehara
Highly effective extraction of carcinoembryonic antigen with phosphatidylinositol-specific phospholipase C.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 1991;12(2):91-8.
1990: N Takami; K Oda; Toshiyuki Fujiwara; Yukio Ikehara
Intracellular accumulation and oligosaccharide processing of alkaline phosphatase under disassembly of the Golgi complex caused by brefeldin A.
European journal of biochemistry / FEBS 1990;194(3):805-10.
1990: Yoshio Misumi; Miwa Sohda; Yukio Ikehara
Sequence of the cDNA encoding rat furin, a possible propeptide-processing endoprotease.
Nucleic acids research 1990;18(22):6719.
1990: K Oda; Toshiyuki Fujiwara; S Ogata; Yukio Ikehara
Production of propeptide-directed antibody: its application to the purification of proalbumin and analysis of proalbumin processing.
Journal of biochemistry 1990;108(4):549-53.
1990: Yoshio Misumi; K Ohkubo; Miwa Sohda; N Takami; K Oda; Yukio Ikehara
Intracellular processing of complement pro-C3 and proalbumin is inhibited by rat alpha 1-protease inhibitor variant (Met352----Arg) in transfected cells.
Biochemical and biophysical research communications 1990;171(1):236-42.
1990: S Ogata; Y Hayashi; Yoshio Misumi; Yukio Ikehara
Membrane-anchoring domain of rat liver 5'-nucleotidase: identification of the COOH-terminal serine-523 covalently attached with a glycolipid.
Biochemistry 1990;29(34):7923-7.
1990: Yoshio Misumi; S Ogata; K Ohkubo; S Hirose; Yukio Ikehara
Primary structure of human placental 5'-nucleotidase and identification of the glycolipid anchor in the mature form.
European journal of biochemistry / FEBS 1990;191(3):563-9.
1990: Yoshio Misumi; Miwa Sohda; K Ohkubo; N Takami; K Oda; Yukio Ikehara
Molecular cloning and sequencing of the cDNA of rat alpha 1-protease inhibitor and its expression in COS-1 cells.
Journal of biochemistry 1990;108(2):230-4.
1990: Yoshio Misumi; Miwa Sohda; Yukio Ikehara
Nucleotide and deduced amino acid sequence of rat complement C3.
Nucleic acids research 1990;18(8):2178.
1990: Y Takada; Jun Sasaki; S Ogata; T Nakanishi; Yukio Ikehara; Kikuo Arakawa
Isolation and characterization of human apolipoprotein A-I Fukuoka (110 Glu----Lys). A novel apolipoprotein variant.
Biochimica et biophysica acta 1990;1043(2):169-76.
1990: Yoshio Misumi; S Ogata; S Hirose; Yukio Ikehara
Primary structure of rat liver 5'-nucleotidase deduced from the cDNA. Presence of the COOH-terminal hydrophobic domain for possible post-translational modification by glycophospholipid.
The Journal of biological chemistry 1990;265(4):2178-83.
1990: K Oda; Toshiyuki Fujiwara; Yukio Ikehara
Brefeldin A arrests the intracellular transport of viral envelope proteins in primary cultured rat hepatocytes and HepG2 cells.
The Biochemical journal 1990;265(1):161-7.
1989: C Toki; K Oda; Yukio Ikehara
Demonstration of GTP-binding proteins and ADP-ribosylated proteins in rat liver Golgi fraction.
Biochemical and biophysical research communications 1989;164(1):333-8.
1989: Toshiyuki Fujiwara; K Oda; Yukio Ikehara
Dynamic distribution of the Golgi marker thiamine pyrophosphatase is modulated by brefeldin A in rat hepatoma cells.
Cell structure and function 1989;14(5):605-16.
1989: K Oda; N Takami; Toshiyuki Fujiwara; Yoshio Misumi; Yukio Ikehara
Proalbumin is processed to serum albumin in COS-1 cells transfected with cDNA for rat albumin.
Biochemical and biophysical research communications 1989;163(1):194-200.
1989: S Ogata; Yoshio Misumi; Yukio Ikehara
Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain.
The Journal of biological chemistry 1989;264(6):3596-601.
1988: Toshiyuki Fujiwara; K Oda; S Yokota; A Takatsuki; Yukio Ikehara
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.
The Journal of biological chemistry 1988;263(34):18545-52.
1988: K Oda; S Ogata; Y Koriyama; E Yamada; K Mifune; Yukio Ikehara
Tris inhibits both proteolytic and oligosaccharide processing occurring in the Golgi complex in primary cultured rat hepatocytes.
The Journal of biological chemistry 1988;263(25):12576-83.
1988: N Takami; Yoshio Misumi; Masahide Kuroki; Y Matsuoka; Yukio Ikehara
Evidence for carboxyl-terminal processing and glycolipid-anchoring of human carcinoembryonic antigen.
The Journal of biological chemistry 1988;263(25):12716-20.
1988: K Oda; Yukio Ikehara
Putative convertase involved in the proteolytic conversion of rat proalbumin to serum albumin.
Journal of biochemistry 1988;104(2):159-61.
1988: S Ogata; Y Hayashi; N Takami; Yukio Ikehara
Chemical characterization of the membrane-anchoring domain of human placental alkaline phosphatase.
The Journal of biological chemistry 1988;263(21):10489-94.
1988: S Hirose; K Oda; Yukio Ikehara
Tyrosine O-sulfation of the fibrinogen gamma B chain in primary cultures of rat hepatocytes.
The Journal of biological chemistry 1988;263(15):7426-30.
1988: S Hirose; K Oda; Yukio Ikehara
Biosynthesis, assembly and secretion of fibrinogen in cultured rat hepatocytes.
The Biochemical journal 1988;251(2):373-7.
1988: N Takami; S Ogata; K Oda; Yoshio Misumi; Yukio Ikehara
Biosynthesis of placental alkaline phosphatase and its post-translational modification by glycophospholipid for membrane-anchoring.
The Journal of biological chemistry 1988;263(6):3016-21.
1988: Yoshio Misumi; K Tashiro; M Hattori; Y Sakaki; Yukio Ikehara
Primary structure of rat liver alkaline phosphatase deduced from its cDNA.
The Biochemical journal 1988;249(3):661-8.
1987: S Ogata; Y Hayashi; K Yasutake; Yukio Ikehara
Chemical identification of lipid components in the membranous form of rat liver alkaline phosphatase.
Journal of biochemistry 1987;102(6):1609-15.