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Ognian Ikonomov

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Chemicals & Drugs

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Circadian Rhythm

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Diego Sbrissa; Khortnal Delvecchio; Catherine Filios; Ognian C Ikonomov; Assia Shisheva
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
Ognian C Ikonomov; Diego Sbrissa; Khortnal Delvecchio; Yufen Xie; J-P Jin; Daniel A Rappolee; Assia Shisheva
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
Ognian C Ikonomov; Diego Sbrissa; Jason Fligger; Khortnal Delvecchio; Assia Shisheva
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.

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All Publications

2012: Diego Sbrissa; Khortnal Delvecchio; Catherine Filios; Ognian C Ikonomov; Assia Shisheva
Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
American journal of physiology. Cell physiology 2012;303(4):C436-46.
2011: Ognian C Ikonomov; Diego Sbrissa; Khortnal Delvecchio; Yufen Xie; J-P Jin; Daniel A Rappolee; Assia Shisheva
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
The Journal of biological chemistry 2011;286(15):13404-13.
2010: Ognian C Ikonomov; Diego Sbrissa; Jason Fligger; Khortnal Delvecchio; Assia Shisheva
ArPIKfyve regulates Sac3 protein abundance and turnover: disruption of the mechanism by Sac3I41T mutation causing Charcot-Marie-Tooth 4J disorder.
The Journal of biological chemistry 2010;285(35):26760-4.
2009: Ognian C Ikonomov; Diego Sbrissa; Homer Fenner; Assia Shisheva
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
The Journal of biological chemistry 2009;284(51):35794-806.
2009: Ognian C Ikonomov; Diego Sbrissa; Takeshi Ijuin; Tadaomi Takenawa; Assia Shisheva
Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.
The Journal of biological chemistry 2009;284(36):23961-71.
2009: Ognian C Ikonomov; Diego Sbrissa; Assia Shisheva
YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.
Biochemical and biophysical research communications 2009;382(3):566-70.
2009: Ognian C Ikonomov; Jason Fligger; Diego Sbrissa; Rajeswari Dondapati; Krzysztof Mlak; Robert Deeb; Assia Shisheva
Kinesin adapter JLP links PIKfyve to microtubule-based endosome-to-trans-Golgi network traffic of furin.
The Journal of biological chemistry 2009;284(6):3750-61.
2008: Diego Sbrissa; Ognian C Ikonomov; Homer Fenner; Assia Shisheva
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
Journal of molecular biology 2008;384(4):766-79.
2007: Diego Sbrissa; Ognian C Ikonomov; Zhiyao Fu; Takeshi Ijuin; Jean Gruenberg; Tadaomi Takenawa; Assia Shisheva
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex.
The Journal of biological chemistry 2007;282(33):23878-91.
2007: Ognian C Ikonomov; Diego Sbrissa; Rajeswari Dondapati; Assia Shisheva
ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.
Experimental cell research 2007;313(11):2404-16.
2006: Ognian C Ikonomov; Diego Sbrissa; Assia Shisheva
Localized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusion.
American journal of physiology. Cell physiology 2006;291(2):C393-404.
2005: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
Analysis of potential binding of the recombinant Rab9 effector p40 to phosphoinositide-enriched synthetic liposomes.
Methods in enzymology 2005;403():696-705.
2004: Diego Sbrissa; Ognian C Ikonomov; Jana Strakova; Rajeswari Dondapati; Krzysztof Mlak; Robert Deeb; Robert B Silver; Assia Shisheva
A mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activity.
Molecular and cellular biology 2004;24(23):10437-47.
2004: Diego Sbrissa; Ognian C Ikonomov; Jana Strakova; Assia Shisheva
Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation.
Endocrinology 2004;145(11):4853-65.
2004: Rina Mikhailovna Zaslavskaya; Galina Victorovna Lilitsa; G S Dilmagambetova; Franz Halberg; Germaine Cornélissen; Kuniaki Otsuka; Ram Singh; Alexander Stoynev; Ognian C Ikonomov; Roberto Tarquini; Federico Perfetto; Othild Schwartzkopff; Earl E Bakken
Melatonin, refractory hypertension, myocardial ischemia and other challenges in nightly blood pressure lowering.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2004;58 Suppl 1():S129-34.
2004: L D Sabath; Germaine Cornélissen; Franz Halberg; Alexander Stoynev; Ognian C Ikonomov; Kuniaki Otsuka
Circadian hypo- and hyper-amplitude-tension (CHAT) associated with putative pheochromocytoma and 12-hourly phenoxybenzamine treatment.
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie 2004;58 Suppl 1():S99-106.
2003: Ognian C Ikonomov; Diego Sbrissa; Krzysztof Mlak; Robert Deeb; Jason Fligger; Aleric Soans; Russell L Finley; Assia Shisheva
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
The Journal of biological chemistry 2003;278(51):50863-71.
2003: Franz Halberg; Germaine Cornélissen; Alexander Stoynev; Ognian C Ikonomov; George Katinas; Mary Sampson; Zhengrong Wang; Chaomin Wan; Ram Singh; Kuniaki Otsuka; Robert Sothern; Samuel B Sothern; Margaret I Sothern; Elena V Syutkina; Anatoly Masalov; Federico Perfetto; Roberto Tarquini; Cristina Maggioni; Yuji Kumagai; Jarmila Siegelova; Bohumil Fiser; Pavel Homolka; Jiri Dusek; Keiko Uezono; Yoshihiko Watanabe; Jinyi Wu; Pavel Prikryl; Michael Blank; Olga Blank; Robert Sonkowsky; Othild Schwartzkopff; Theodor Hellbrügge; Novera Herbert Spector; Ion Baciu; Monica Hriscu; Earl Bakken
Season's appreciations 2002 and 2003. Imaging in time: the transyear (longer-than-the-calendar year) and the half-year.
Neuro endocrinology letters 2003;24(6):479-98.
2003: Ognian C Ikonomov; Diego Sbrissa; Michelangelo Foti; Jean-Louis Carpentier; Assia Shisheva
PIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesis.
Molecular biology of the cell 2003;14(11):4581-91.
2002: Diego Sbrissa; Ognian C Ikonomov; Robert Deeb; Assia Shisheva
Phosphatidylinositol 5-phosphate biosynthesis is linked to PIKfyve and is involved in osmotic response pathway in mammalian cells.
The Journal of biological chemistry 2002;277(49):47276-84.
2002: Ognian C Ikonomov; Diego Sbrissa; Krzysztof Mlak; Assia Shisheva
Requirement for PIKfyve enzymatic activity in acute and long-term insulin cellular effects.
Endocrinology 2002;143(12):4742-54.
2002: Ognian C Ikonomov; Diego Sbrissa; Tamotsu Yoshimori; Timothy L Cover; Assia Shisheva
PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin.
The Journal of biological chemistry 2002;277(48):46785-90.
2002: Ognian C Ikonomov; Diego Sbrissa; Krzysztof Mlak; Makoto Kanzaki; Jeffrey Pessin; Assia Shisheva
Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity.
The Journal of biological chemistry 2002;277(11):9206-11.
2002: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.
The Journal of biological chemistry 2002;277(8):6073-9.
2001: Ognian C Ikonomov; Diego Sbrissa; Assia Shisheva
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyve.
The Journal of biological chemistry 2001;276(28):26141-7.
2001: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
Selective insulin-induced activation of class I(A) phosphoinositide 3-kinase in PIKfyve immune complexes from 3T3-L1 adipocytes.
Molecular and cellular endocrinology 2001;181(1-2):35-46.
2001: Assia Shisheva; B Rusin; Ognian C Ikonomov; Carmen E DeMarco; Diego Sbrissa
Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes.
The Journal of biological chemistry 2001;276(15):11859-69.
2000: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
PIKfyve lipid kinase is a protein kinase: downregulation of 5'-phosphoinositide product formation by autophosphorylation.
Biochemistry 2000;39(51):15980-9.
2000: P Allaire; Ognian C Ikonomov; M K Garrett; Michele H Jacob
Synaptic interactions regulate gephyrin expression in avian cholinergic neurons in vivo.
Neuropharmacology 2000;39(13):2691-8.
2000: Ognian C Ikonomov; Theodor Petrov; K Soden; Assia Shisheva; Husseini K Manji
Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO.
Brain research. Developmental brain research 2000;123(1):13-24.
2000: G Tsen; B Williams; P Allaire; Y D Zhou; Ognian C Ikonomov; I Kondova; Michele H Jacob
Receptors with opposing functions are in postsynaptic microdomains under one presynaptic terminal.
Nature neuroscience 2000;3(2):126-32.
1999: Ognian C Ikonomov; Husseini K Manji
Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge.
The American journal of psychiatry 1999;156(10):1506-14.
1999: Diego Sbrissa; Ognian C Ikonomov; Assia Shisheva
PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin.
The Journal of biological chemistry 1999;274(31):21589-97.
1999: AG Stoynev; P D Penev; A V Peneva; G Cornelissen; F Halberg; Ognian C Ikonomov
Blood pressure and heart rate rhythmicity: differential effects of late pregnancy.
Physiology & behavior 1999;66(2):269-75.
1999: Ognian C Ikonomov; Assia Shisheva; AG Stoynev
Circadian clocks and hypertension: genetics and interactions.
Acta physiologica et pharmacologica Bulgarica 1999;24(3):65-70.
1999: AG Stoynev; Ognian C Ikonomov; NK Minkova; S Z Zacharieva; V G Stoyanovsky
Circadian rhythms of arterial pressure: basic regulatory mechanisms and clinical value.
Acta physiologica et pharmacologica Bulgarica 1999;24(3):43-51.
1999: Assia Shisheva; Diego Sbrissa; Ognian C Ikonomov
Cloning, characterization, and expression of a novel Zn2+-binding FYVE finger-containing phosphoinositide kinase in insulin-sensitive cells.
Molecular and cellular biology 1999;19(1):623-34.
1998: Ognian C Ikonomov; M C Kulesa; Assia Shisheva; M H Jacob
Innervation and target tissue interactions induce Rab-GDP dissociation inhibitor (GDI) expression during peripheral synapse formation in developing chick ciliary ganglion neurons in situ.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998;18(16):6331-9.
1998: Ognian C Ikonomov; AG Stoynev; Assia Shisheva
Integrative coordination of circadian mammalian diversity: neuronal networks and peripheral clocks.
Progress in neurobiology 1998;54(1):87-97.
1996: Ognian C Ikonomov; Michele H Jacob
Differential display protocol with selected primers that preferentially isolates mRNAs of moderate- to low-abundance in a microscopic system.
BioTechniques 1996;20(6):1030-4, 1036-8, 1040-2.
1996: AG Stoynev; P D Penev; Ognian C Ikonomov; K G Usunoff
Effect of transplantation of embryonic anterior hypothalamic tissue from spontaneously hypertensive rats to normotensive Wistar rats on circadian rhythms of systolic arterial pressure and heart rate.
Acta physiologica et pharmacologica Bulgarica 1996;22(3-4):71-5.
1996: AG Stoynev; P D Penev; Ognian C Ikonomov; F Halberg
Suprachiasmatic nuclei lesions eliminate the group circadian rhythm of systolic arterial pressure but not of heart rate in rats.
Acta physiologica et pharmacologica Bulgarica 1996;22(1):1-6.
1994: Assia Shisheva; Ognian C Ikonomov; Yoram Shechter
The protein tyrosine phosphatase inhibitor, pervanadate, is a powerful antidiabetic agent in streptozotocin-treated diabetic rats.
Endocrinology 1994;134(1):507-10.
1994: Ognian C Ikonomov; AG Stoynev
Gene expression in suprachiasmatic nucleus and circadian rhythms.
Neuroscience and biobehavioral reviews 1994;18(3):305-12.
1994: Ognian C Ikonomov; AG Stoynev; Assia Shisheva
Circadian function of suprachiasmatic nuclei: molecular and cellular biology.
Chronobiologia 1994;21(1-2):71-7.
1991: Ognian C Ikonomov; G Stoynev; G Cornélissen; AG Stoynev; D Hillman; N Madjirova; R Kane; F Halberg
The blood pressure and heart rate chronome of centenarians.
Chronobiologia 1991;18(4):167-79.
1991: Ognian C Ikonomov; Assia Shisheva; AG Stoynev; I V Kurtev
Peripheral p-chloroamphetamine is an unsuitable probe for investigation of central serotoninergic control on renal renin secretion in the rat.
Physiology & behavior 1991;49(6):1119-28.
1991: N Belova; N Tzaneva; T Avramova; Ognian C Ikonomov; AG Stoynev; I Damova; B Piryova; N Natcheff; H G Klein
Renal excretory function, atrial natriuretic peptide (ANP) and plasma renin activity (PRA) during long-term sodium loading in rats.
Acta physiologica et pharmacologica Bulgarica 1991;17(2-3):104-10.
1991: AG Stoynev; P D Penev; Ognian C Ikonomov
A reliable technique for midline stereotaxic cannulation of the third ventricle in the rat.
Acta physiologica et pharmacologica Bulgarica 1991;17(2-3):135-8.
1991: Assia Shisheva; T Dimitrov; Ognian C Ikonomov
Plasma angiotensin-converting enzyme activity and blood pressure during the first year of life in normotensive and spontaneously hypertensive rat.
Acta physiologica Hungarica 1991;77(2):129-38.
1990: AG Stoynev; Ognian C Ikonomov; I A Damova; P D Penev; K G Usunoff; A M Paloff
Suprachiasmatic nuclei lesions eliminate light/dark variations in short-term feeding responses to deprivation or insulin treatment in rats.
Physiology & behavior 1990;48(6):795-9.
1990: Ognian C Ikonomov; AG Stoynev; I I Goranova-Stoyneva; A Popov; V A Minkova
Nephrotoxic effect of the specific brain serotonin depletor para-chlorophenylalanine.
Acta physiologica Hungarica 1990;76(3):191-9.
1990: Assia Shisheva; A Stoĭnev; Ognian C Ikonomov
[A method for determining the angiotensin-converting enzyme activity in the rat hypothalamus and hypophysis].
Eksperimentalna meditsina i morfologiia 1990;29(2):33-41.
1989: AG Stoynev; Ognian C Ikonomov
A method for continuous infusion and blood sampling in unanaesthetized rats.
Acta physiologica et pharmacologica Bulgarica 1989;15(3):59-64.
1988: AG Stoynev; Ognian C Ikonomov
[Neuroendocrine mechanisms in the circadian regulation of feeding in the rat].
Endocrinologie 1988;26(3):159-64.
1988: Ognian C Ikonomov; N C Vrabchev; AG Stoynev
Effect of bevelling on C1-selective microelectrodes: experimental and model study.
Acta physiologica et pharmacologica Bulgarica 1988;14(4):84-90.
1987: AG Stoynev; Ognian C Ikonomov
Circadian regulation of feeding in rats: suprachiasmatic versus ventromedial hypothalamic nuclei.
Appetite 1987;9(3):217-29.
1987: Assia Shisheva; Ognian C Ikonomov; AG Stoynev; J Popova
Renin release and water-salt balance after central serotonin depletion by p-chlorophenylalanine in Brattleboro and Wistar rats: possible role of ADH.
Endocrinologia experimentalis 1987;21(3):219-28.
1986: AG Stoynev; Ognian C Ikonomov; N C Vrabchev; K G Usunoff
Suprachiasmatic nuclei lesions do not eliminate the circadian rhythms of electrolyte excretion in the rat.
Physiology & behavior 1986;38(5):657-62.
1986: B Piryova; Ognian C Ikonomov; AG Stoynev; N Natcheff
Renin-angiotensin system and renal excretory function under conditions of hypovolemia and limited sodium intake.
Acta physiologica et pharmacologica Bulgarica 1986;12(2):21-6.
1986: Ognian C Ikonomov; Assia Shisheva; AG Stoynev; I V Kurtev
Effect on the plasma renin-aldosterone system of lesions to suprachiasmatic nuclei and central serotonin depletion in rats.
Acta physiologica Hungarica 1986;68(2):211-9.
1985: Ognian C Ikonomov; AG Stoynev; Assia Shisheva; N T Tarkolev
Effect of constant light and darkness on the circadian rhythms in rats. II. Plasma renin activity and insulin concentration.
Acta physiologica et pharmacologica Bulgarica 1985;11(1):55-61.
1985: Ognian C Ikonomov; AG Stoynev; N C Vrabchev; Assia Shisheva; N T Tarkolev
Circadian rhythms of food and 1% NaCl intake, urine and electrolyte excretion, plasma renin activity and insulin concentration in adrenalectomized rats.
Acta physiologica Hungarica 1985;65(2):181-98.
1984: Ognian C Ikonomov; AG Stoynev; I V Kurtev
Effect of morphine withdrawal on food and water intake, urine output and electrolyte excretion in the rat: participation of the renin-aldosterone-system in renal excretory changes.
Acta physiologica Hungarica 1984;63(2):137-46.
1983: AG Stoynev; Ognian C Ikonomov
Effect of constant light and darkness on the circadian rhythms in rats: I. Food and water intake, urine output and electrolyte excretion.
Acta physiologica et pharmacologica Bulgarica 1983;9(3):58-64.
1982: AG Stoynev; Ognian C Ikonomov; K G Usunoff
Feeding pattern and light-dark variations in water intake and renal excretion after suprachiasmatic nuclei lesions in rats.
Physiology & behavior 1982;29(1):35-40.
1981: Ognian C Ikonomov; AG Stoynev; N Vrabchev
Simultaneous study of the circadian rhythms of food intake, water intake and renal excretion and analysis of their interrelations in rats.
Acta physiologica et pharmacologica Bulgarica 1981;7(1):77-84.
1981: N Vrabchev; AG Stoynev; Ognian C Ikonomov
Automated analysis of circadian rhythms when data are collected at intervals.
Acta physiologica et pharmacologica Bulgarica 1981;7(1):69-76.
1981: Ognian C Ikonomov; AG Stoynev; Assia Shisheva; N Tarkolev
[Circadian rhythms of plasma renin activity and the plasma concentration of aldosterone and insulin in the rat: effect of renal denervation and food restriction].
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression 1981;22(6):247-53.
1981: A Stoĭnev; Ognian C Ikonomov
[Circadian rhythms in laboratory rats (general characteristics and endocrine aspects)].
Eksperimentalna meditsina i morfologiia 1981;20(1):1-7.
1980: AG Stoynev; Ognian C Ikonomov; N Tarkolev; Assia Shisheva
Effects of suprachiasmatic nuclei (SCN) lesions on the circadian variations in PRA and IRI level in the rat.
Acta physiologica Academiae Scientiarum Hungaricae 1980;56(4):431-5.
1980: AG Stoynev; Ognian C Ikonomov; N Tarkolev
[Effects of anesthesia and adaptation to manipulations and conditions of sacrifice on renin activity and plasma concentration of angiotensin II in rats].
Agressologie: revue internationale de physio-biologie et de pharmacologie appliquées aux effets de l'agression 1980;21(3):143-5.
1979: A Stoynev; Ognian C Ikonomov
Method for simultaneous investigation of feeding and drinking behaviours and renal excretory function in small animals.
Acta physiologica et pharmacologica Bulgarica 1979;5(4):77-81.
1979: Ognian C Ikonomov; A Stoĭnev
[Kidney renin-angiotensin system and water intake].
Eksperimentalna meditsina i morfologiia 1979;18(4):193-200.