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Dong-Soon Im

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Dong-Soon Im
Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs.
Dong-Soon Im
First-in-class antifibrotic therapy targeting type 1 lysophosphatidic acid receptor.
Mayumi Komachi; Chihiro Mogi; Hideo Ohta; Koichi Sato; Izumi Takeyoshi; Masayuki Tobo; Hideaki Tomura; Takayuki Yamada; Keisuke Yanagida; Dong-Soon Im; Satoshi Ishii; Takao Kimura; Fumikazu Okajima
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.

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All Publications

2012: Dong-Soon Im
Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs.
Progress in lipid research 2012;51(3):232-7.
2012: Dong-Soon Im
First-in-class antifibrotic therapy targeting type 1 lysophosphatidic acid receptor.
Archives of pharmacal research 2012;35(6):945-8.
2012: Mayumi Komachi; Chihiro Mogi; Hideo Ohta; Koichi Sato; Izumi Takeyoshi; Masayuki Tobo; Hideaki Tomura; Takayuki Yamada; Keisuke Yanagida; Dong-Soon Im; Satoshi Ishii; Takao Kimura; Fumikazu Okajima
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
Cancer science 2012;103(6):1099-104.
2011: Takao Kimura; Hitoshi Kurose; Atsushi Kuwabara; Chihiro Mogi; Masami Murakami; Hideo Ohta; Koichi Sato; Hideaki Tomura; Dong-Soon Im; Fumikazu Okajima
p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1.
Cardiovascular research 2011;92(1):149-58.
2011: Dong-Soon Im
A promising anti-inflammatory and anti-thrombotic drug for sepsis treatment.
Archives of pharmacal research 2011;34(3):339-42.
2010: Dong-Soon Im
Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.
Acta pharmacologica Sinica 2010;31(9):1213-22.
2010: Mi Ran Yun; Hye M Park; Kyo W Seo; Seung J Lee; Dong-Soon Im; Chi D Kim
5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase.
Free radical research 2010;44(7):742-50.
2010: Takao Kimura; Hideaki Tomura; Koichi Sato; Masaaki Ito; Isao Matsuoka; Dong-Soon Im; Atsushi Kuwabara; Chihiro Mogi; Hiroshi Itoh; Hitoshi Kurose; Masami Murakami; Fumikazu Okajima
Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells.
The Journal of biological chemistry 2010;285(7):4387-97.
2009: Santosh J Sacket; Hae-Young Chung; Fumikazu Okajima; Dong-Soon Im
Increase in sphingolipid catabolic enzyme activity during aging.
Acta pharmacologica Sinica 2009;30(10):1454-61.
2009: Dong-Soon Im
New intercellular lipid mediators and their GPCRs: an update.
Prostaglandins & other lipid mediators 2009;89(3-4):53-6.
2009: Mi Ran Yun; Dong-Soon Im; Seung J Lee; Hye M Park; Sun Sik Bae; Won S Lee; Chi Dae Kim
4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase.
Free radical biology & medicine 2009;46(5):692-8.
2009: Mayumi Komachi; Hideaki Tomura; Enkhzol Malchinkhuu; Masayuki Tobo; Chihiro Mogi; Takayuki Yamada; Takao Kimura; Atsushi Kuwabara; Hideo Ohta; Dong-Soon Im; Hitoshi Kurose; Izumi Takeyoshi; Koichi Sato; Fumikazu Okajima
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
Carcinogenesis 2009;30(3):457-65.
2008: Takao Kimura; Chihiro Mogi; Hideaki Tomura; Atsushi Kuwabara; Dong-Soon Im; Koichi Sato; Hitoshi Kurose; Masami Murakami; Fumikazu Okajima
Induction of scavenger receptor class B type I is critical for simvastatin enhancement of high-density lipoprotein-induced anti-inflammatory actions in endothelial cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):7332-40.
2008: Santosh J Sacket; Dong-Soon Im
Discovery of sphingosine 1-O-methyltransferase in rat kidney and liver homogenates.
Acta pharmacologica Sinica 2008;29(10):1227-32.
2008: Young-whan Choi; Kyeok Kim; Ji-yeong Jo; Hyo-Lim Kim; You-jin Lee; Woo-jung Shin; Santosh J Sacket; Mijin Han; Dong-Soon Im
Wuweizisu C from Schisandra chinensis decreases membrane potential in C6 glioma cells.
Acta pharmacologica Sinica 2008;29(9):1006-12.
2008: Ji-Yeong Jo; Hyo-Lim Kim; Yun-Kyung Lee; Hideaki Tomura; Yoe-Sik Bae; Fumikazu Okajima; Dong-Soon Im
N,N-Dimethyl-D-erythro-sphingosine inhibits store-operated Ca2+ entry in U937 monocytes.
Journal of pharmacological sciences 2008;107(3):303-7.
2008: Hideaki Tomura; Ju-Qiang Wang; Jin-Peng Liu; Mayumi Komachi; Alatangaole Damirin; Chihiro Mogi; Masayuki Tobo; Hiromi Nochi; Koichi Tamoto; Dong-Soon Im; Koichi Sato; Fumikazu Okajima
Cyclooxygenase-2 expression and prostaglandin E2 production in response to acidic pH through OGR1 in a human osteoblastic cell line.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2008;23(7):1129-39.
2008: Mijin Han; Dong-Soon Im
Effects of mitochondrial inhibitors on cell viability in U937 monocytes under glucose deprivation.
Archives of pharmacal research 2008;31(6):749-57.
2008: Hyo-Lim Kim; Mijin Han; Dong-Soon Im
Differential signaling of sphingosine derivatives in U937 human monocytes depends on the degree of N-methylation.
Prostaglandins & other lipid mediators 2008;86(1-4):68-72.
2008: Hyo-Lim Kim; Santosh J Sacket; Mijin Han; Dong-Soon Im
Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition.
Prostaglandins & other lipid mediators 2008;86(1-4):18-25.
2008: Young-Ja Chang; Yu-Lee Kim; Ji-Yeong Jo; Kim Kyeok; Hyo-Lim Kim; Dong-Soon Im
Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.
Archives of pharmacal research 2008;31(5):628-33.
2008: Kyeok Kim; Hyo-Lim Kim; Yun-Kyung Lee; Mijin Han; Santosh J Sacket; Ji-Yeong Jo; Yu-Lee Kim; Dong-Soon Im
Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.
Archives of pharmacal research 2008;31(3):310-7.
2008: Hyo-Lim Kim; Dong-Soon Im
N, N-dimethyl-D-erythro-sphingosine increases intracellular Ca2+ concentration via Na+-Ca2+-exchanger in HCT116 human colon cancer cells.
Archives of pharmacal research 2008;31(1):54-9.
2008: Sung-Koun Heo; Jeiwon Cho; Ji-Woong Cheon; Min-Koo Choi; Dong-Soon Im; Jung Ju Kim; Yang Gyu Choi; Do Yong Jeon; Suk-Jae Chung; Chang-Koo Shim; Dae-Duk Kim
Pharmacokinetics and pharmacodynamics of ketoprofen plasters.
Biopharmaceutics & drug disposition 2008;29(1):37-44.
2007: Mijin Han; Yu-Lee Kim; Santosh J Sacket; Kyeok Kim; Hyo-Lim Kim; Ji-Yeong Jo; Nam-Chul Ha; Dong-Soon Im
Effect of direct albumin binding to sphingosylphosphorylcholine in Jurkat T cells.
Prostaglandins & other lipid mediators 2007;84(3-4):174-83.
2007: Yun-Kyung Lee; Kyeok Kim; Hyo-Lim Kim; Santosh J Sacket; Mijin Han; Ji-Yeong Jo; Dong-Soon Im
Lysophosphatidylserine increases membrane potentials in rat C6 glioma cells.
Archives of pharmacal research 2007;30(9):1096-101.
2007: Kyeok Kim; Yu-Lee Kim; Santosh J Sacket; Hyo-Lim Kim; Mijin Han; Deok Seong Park; Baeck Kyoung Lee; Won Koo Lee; Hyun-Joon Ha; Dong-Soon Im
Sphingosine 1-phosphate (S1P) induces shape change in rat C6 glioma cells through the S1P2 receptor: development of an agonist for S1P receptors.
The Journal of pharmacy and pharmacology 2007;59(7):1035-41.
2007: Young-Ja Chang; Yu-Lee Kim; Yun-Kyung Lee; Santosh J Sacket; Kyeok Kim; Hyo-Lim Kim; Mijin Han; Yoe-Sik Bae; Fumikazu Okajima; Dong-Soon Im
Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.
Prostaglandins & other lipid mediators 2007;83(4):268-76.
2007: Yani Zou; Chul H Kim; Jae H Chung; Ji Y Kim; Sang W Chung; Mi K Kim; Dong-Soon Im; Jaewon Lee; Byung Pal Yu; Hae Y Chung
Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.
The FEBS journal 2007;274(10):2573-84.
2007: Alatangaole Damirin; Hideaki Tomura; Mayumi Komachi; Jin-Peng Liu; Chihiro Mogi; Masayuki Tobo; Ju-Qiang Wang; Takao Kimura; Atsushi Kuwabara; Yuji Yamazaki; Hideo Ohta; Dong-Soon Im; Koichi Sato; Fumikazu Okajima
Role of lipoprotein-associated lysophospholipids in migratory activity of coronary artery smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2513-22.
2007: Yup-Kyung Lee; Hyo-Lim Kim; Yu-Lee Kim; Dong-Soon Im
Multiple actions of dimethylsphingosine in 1321N1 astrocytes.
Molecules and cells 2007;23(1):11-6.
2007: Yu-Lee Kim; Young-Jin Im; Nam-Chul Ha; Dong-Soon Im
Albumin inhibits cytotoxic activity of lysophosphatidylcholine by direct binding.
Prostaglandins & other lipid mediators 2007;83(1-2):130-8.
2006: Yu-Lee Kim; Young-Jin Im; Yun-Kyung Lee; Nam-Chul Ha; Yoe-Sik Bae; Sung-Mee Lim; Fumikazu Okajima; Dong-Soon Im
Albumin functions as an inhibitor of T cell adhesion in vitro.
Biochemical and biophysical research communications 2006;351(4):953-7.
2006: Takao Kimura; Hideaki Tomura; Chihiro Mogi; Atsushi Kuwabara; Alatangaole Damirin; Tamotsu Ishizuka; Akihiro Sekiguchi; Mitsuteru Ishiwara; Dong-Soon Im; Koichi Sato; Masami Murakami; Fumikazu Okajima
Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.
The Journal of biological chemistry 2006;281(49):37457-67.
2006: Yun-Kyung Lee; Young-Jin Im; Yu-Lee Kim; Dong-Soon Im
Characterization of Ca2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes.
Biochemical and biophysical research communications 2006;348(3):1116-22.
2006: Young-Ja Chang; Yun-Kyung Lee; Eun-Hee Lee; Jeong-Ju Park; Sung-Kee Chung; Dong-Soon Im
Structure-activity relationships of dimethylsphingosine (DMS) derivatives and their effects on intracellular pH and Ca2+ in the U937 monocyte cell line.
Archives of pharmacal research 2006;29(8):657-65.
2006: Young-Jin Im; Yun-Kyung Lee; Hae Young Chung; Dong-Soon Im
Multiple actions of lysophosphatidylcholine in human Jurkat T cells.
Acta pharmacologica Sinica 2006;27(6):700-7.
2006: Takao Kimura; Hideaki Tomura; Chihiro Mogi; Atsushi Kuwabara; Mitsuteru Ishiwara; Kunihiko Shibasawa; Koichi Sato; Susumu Ohwada; Dong-Soon Im; Hitoshi Kurose; Tamotsu Ishizuka; Masami Murakami; Fumikazu Okajima
Sphingosine 1-phosphate receptors mediate stimulatory and inhibitory signalings for expression of adhesion molecules in endothelial cells.
Cellular signalling 2006;18(6):841-50.
2006: Mi Ran Yun; Dong-Soon Im; Jong-Soo Lee; Seok Man Son; Sang-Min Sung; Sun Sik Bae; Chi Dae Kim
NAD(P)H oxidase-stimulating activity of serum from type 2 diabetic patients with retinopathy mediates enhanced endothelial expression of E-selectin.
Life sciences 2006;78(22):2608-14.
2006: Eun-Hee Lee; Yun-Kyung Lee; Young-Jin Im; Jae-Ho Kim; Fumikazu Okajima; Dong-Soon Im
Dimethylsphingosine regulates intracellular pH and Ca(2+) in human monocytes.
Journal of pharmacological sciences 2006;100(4):289-96.
2005: Dong-Soon Im
Two ligands for a GPCR, proton vs lysolipid.
Acta pharmacologica Sinica 2005;26(12):1435-41.
2005: Eun Su Jeon; Yong Jung Kang; Hae Young Song; Dong-Soon Im; Hyeon Soo Kim; Sung Ho Ryu; Yong Keun Kim; Jae Ho Kim
Sphingosylphosphorylcholine generates reactive oxygen species through calcium-, protein kinase Cdelta- and phospholipase D-dependent pathways.
Cellular signalling 2005;17(6):777-87.
2005: Young-Jin Im; Dong-Soon Im; Yun-Kyung Lee; Eun-Hee Lee; Koichi Sato; Hideaki Tomura; Toshiaki Katada; Michio Ui; Fumikazu Okajima
Study on action mode of sphingosine 1-phosphate in rat hepatocytes.
Journal of pharmacological sciences 2005;97(3):443-6.
2004: Eun-hee Lee; Mi Ran Yun; Wei-hong Wang; Jee H Jung; Dong-Soon Im
Structure-activity relationship of lysophosphatidylcholines in HL-60 human leukemia cells.
Acta pharmacologica Sinica 2004;25(11):1521-4.
2004: Mi Ran Yun; Jong Jae Kim; Dong-Soon Im; Seung Don Yang; Chi Dae Kim
Involvement of NAD(P)H oxidase in the enhanced expression of cell adhesion molecules in the aorta of diabetic mice.
Life sciences 2004;75(20):2463-72.
2004: Dong-Soon Im; Hideaki Tomura; Masayuki Tobo; Masayuki Tobe; Koichi Sato; Fumikazu Okajima
Enhancement of sphingosine 1-phosphate-induced phospholipase C activation during G(0)-G(1) transition in rat hepatocytes.
Journal of pharmacological sciences 2004;95(2):284-90.
2004: Hyun-Sook Kim; Eun-Hee Lee; Sung-Ryong Ko; Kang-Ju Choi; Jong-Hee Park; Dong-Soon Im
Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells.
Archives of pharmacal research 2004;27(4):429-35.
2004: Dong-Soon Im
Discovery of new G protein-coupled receptors for lipid mediators.
Journal of lipid research 2004;45(3):410-8.
2004: Takayuki Yamada; Koichi Sato; Mayumi Komachi; Enkhzol Malchinkhuu; Masayuki Tobo; Takao Kimura; Atsushi Kuwabara; Yasuhiro Yanagita; Toshiro Ikeya; Yoshifumi Tanahashi; Tetsushi Ogawa; Susumu Ohwada; Yasuo Morishita; Hideo Ohta; Dong-Soon Im; Koichi Tamoto; Hideaki Tomura; Fumikazu Okajima
Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1.
The Journal of biological chemistry 2004;279(8):6595-605.
2004: Mi Ran Yun; Fumikazu Okajima; Dong-Soon Im
The action mode of lysophosphatidylcholine in human monocytes.
Journal of pharmacological sciences 2004;94(1):45-50.
2003: Hideo Ohta; Koichi Sato; Naoya Murata; Alatangaole Damirin; Enkhzol Malchinkhuu; Junko Kon; Takao Kimura; Masayuki Tobo; Yuji Yamazaki; Tomoko Watanabe; Mikio Yagi; Motoko Sato; Rika Suzuki; Hideko Murooka; Teruyuki Sakai; Tsuyoshi Nishitoba; Dong-Soon Im; Hiromi Nochi; Koichi Tamoto; Hideaki Tomura; Fumikazu Okajima
Ki16425, a subtype-selective antagonist for EDG-family lysophosphatidic acid receptors.
Molecular pharmacology 2003;64(4):994-1005.
2003: Hyun-Sook Kim; Fumikazu Okajima; Dong-Soon Im
Analysis of vasopressin-induced Ca2+ increase in rat hepatocytes.
Archives of pharmacal research 2003;26(1):64-9.
2003: Dong-Soon Im
Linking Chinese medicine and G-protein-coupled receptors.
Trends in pharmacological sciences 2003;24(1):2-4.
2002: Dong-Soon Im
Orphan G protein-coupled receptors and beyond.
Japanese journal of pharmacology 2002;90(2):101-6.
1997: Dong-Soon Im; T Fujioka; T Katada; Yasuto Kondo; Michio Ui; Fumikazu Okajima
Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes.
The American journal of physiology 1997;272(5 Pt 1):G1091-9.
1997: Fumikazu Okajima; Hideaki Tomura; K Sho; Takao Kimura; Ken Sato; Dong-Soon Im; M Akbar; Yasuto Kondo
Sphingosine 1-phosphate stimulates hydrogen peroxide generation through activation of phospholipase C-Ca2+ system in FRTL-5 thyroid cells: possible involvement of guanosine triphosphate-binding proteins in the lipid signaling.
Endocrinology 1997;138(1):220-9.