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Issei Imoto

Research Profile

Anatomy

Physiology

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Gene Dosage

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Nucleic Acid Hybridization

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Genes, Tumor Suppressor

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TOP 3
Yutaka Miyawaki; Kagami Nagai; Yasuaki Nakajima; Tetsuro Nishikage; Yutaka Tokairin; Issei Imoto; Johji Inazawa; Michiko Kajiwara; Kenro Kawada; Tatsuyuki Kawano
Esophageal squamous cell carcinoma developed 11 years after allogeneic bone marrow transplantation for acute lymphatic leukemia.
H Ono; K Sugihara; H Tsuda; Issei Imoto; Ken-ichi Kozaki; Y Kurasawa; T Matsui; T Muramatsu; Johji Inazawa
SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation.
Yutaka Miyawaki; Akishi Ooi; Yoshinobu Eishi; Johji Inazawa; Hiroshi Kawachi; Tatsuyuki Kawano; Issei Imoto
Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma.

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All Publications

2013: Yutaka Miyawaki; Kagami Nagai; Yasuaki Nakajima; Tetsuro Nishikage; Yutaka Tokairin; Issei Imoto; Johji Inazawa; Michiko Kajiwara; Kenro Kawada; Tatsuyuki Kawano
Esophageal squamous cell carcinoma developed 11 years after allogeneic bone marrow transplantation for acute lymphatic leukemia.
Japanese journal of clinical oncology 2013;43(1):69-73.
2012: H Ono; K Sugihara; H Tsuda; Issei Imoto; Ken-ichi Kozaki; Y Kurasawa; T Matsui; T Muramatsu; Johji Inazawa
SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation.
Oncogene 2012;31(47):4923-34.
2012: Yutaka Miyawaki; Akishi Ooi; Yoshinobu Eishi; Johji Inazawa; Hiroshi Kawachi; Tatsuyuki Kawano; Issei Imoto
Genomic copy-number alterations of MYC and FHIT genes are associated with survival in esophageal squamous-cell carcinoma.
Cancer science 2012;103(8):1558-66.
2012: Satoshi Matsumura; Tomoki Muramatsu; Michiie Sakamoto; Shinji Tanaka; Shigeki Arii; Mayuko Furuta; Issei Imoto; Ken-ichi Kozaki; Takeshi Matsui; Johji Inazawa
Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(13):3541-51.
2012: Shozo Honda; Issei Imoto; Yu-Ichi Goto; Shin Hayashi; Mitsuhiro Kato; Takeo Kubota; Kenji Kurosawa; Seiji Mizuno; Eiji Nakagawa; Takaya Nakane; Nobuhiko Okamoto; Hiroshi Yoshihashi; Johji Inazawa
The incidence of hypoplasia of the corpus callosum in patients with dup (X)(q28) involving MECP2 is associated with the location of distal breakpoints.
American journal of medical genetics. Part A 2012;158A(6):1292-303.
2012: Y Kurasawa; T Muramatsu; H Ono; Atiphan Pimkhaokham; Narikazu Uzawa; Teruo Amagasa; Issei Imoto; T Ishihara; Ken-ichi Kozaki; Johji Inazawa
Stabilization of phenotypic plasticity through mesenchymal-specific DNA hypermethylation in cancer cells.
Oncogene 2012;31(15):1963-74.
2012: Nana Okamoto; Tomoko Hasegawa; Akira Hata; Shin Hayashi; Issei Imoto; Rika Kosaki; Yoshio Makita; Ayako Masui; Keiji Moriyama; Izumi Oguri; Johji Inazawa
Deletion at chromosome 10p11.23-p12.1 defines characteristic phenotypes with marked midface retrusion.
Journal of human genetics 2012;57(3):191-6.
2012: Shozo Honda; Issei Imoto; Johji Inazawa; Eiji Nakagawa; Shigeko Satomura; Yu-ichi Goto; Shin Hayashi
Concomitant microduplications of MECP2 and ATRX in male patients with severe mental retardation.
Journal of human genetics 2012;57(1):73-7.
2011: Atsushi Uesugi; Mayuko Furuta; Issei Imoto; Ken-Ichi Kozaki; Kei-Ichi Morita; Ken Omura; Tomohiko Tsuruta; Johji Inazawa
The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer.
Cancer research 2011;71(17):5765-78.
2011: Naotaka Nishiyama; Eri Arai; Ryo Nagashio; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Taiji Tsukamoto; Sana Yokoi; Issei Imoto; Johji Inazawa; Yae Kanai
Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations.
Carcinogenesis 2011;32(4):462-9.
2011: Tomoki Muramatsu; Issei Imoto; Takeshi Matsui; Ken-Ichi Kozaki; Shigeo Haruki; Marius Sudol; Yutaka Shimada; Hitoshi Tsuda; Tatsuyuki Kawano; Johji Inazawa
YAP is a candidate oncogene for esophageal squamous cell carcinoma.
Carcinogenesis 2011;32(3):389-98.
2011: Shin Hayashi; Issei Imoto; Yoshinori Aizu; Nobuhiko Okamoto; Seiji Mizuno; Kenji Kurosawa; Nana Okamoto; Shozo Honda; Satoshi Araki; Shuki Mizutani; Hironao Numabe; Shinji Saitoh; Tomoki Kosho; Yoshimitsu Fukushima; Hiroshi Mitsubuchi; Fumio Endo; Yasutsugu Chinen; Rika Kosaki; Torayuki Okuyama; Hirotaka Ohki; Hiroshi Yoshihashi; Masae Ono; Fumio Takada; Hiroaki Ono; Mariko Yagi; Hiroshi Matsumoto; Yoshio Makita; Akira Hata; Johji Inazawa
Clinical application of array-based comparative genomic hybridization by two-stage screening for 536 patients with mental retardation and multiple congenital anomalies.
Journal of human genetics 2011;56(2):110-24.
2011: Eri Arai; Saori Wakai-Ushijima; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.
Pathobiology : journal of immunopathology, molecular and cellular biology 2011;78(1):1-9.
2011: Masahiro Gotoh; Eri Arai; Saori Wakai-Ushijima; Nobuyoshi Hiraoka; Tomoo Kosuge; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Yae Kanai
Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification.
Journal of biomedicine & biotechnology 2011;2011():780836.
2010: Yasunori Saitoh; Vicente Javier Martínez Bruyn; Shin Uota; Atsuhiko Hasegawa; Naoki Yamamoto; Issei Imoto; Johji Inazawa; Shoji Yamaoka
Overexpression of NF-κB inducing kinase underlies constitutive NF-κB activation in lung cancer cells.
Lung cancer (Amsterdam, Netherlands) 2010;70(3):263-70.
2010: Shozo Honda; Shin Hayashi; Issei Imoto; Jun Toyama; Hitoshi Okazawa; Eiji Nakagawa; Yu-Ichi Goto; Johji Inazawa
Copy-number variations on the X chromosome in Japanese patients with mental retardation detected by array-based comparative genomic hybridization analysis.
Journal of human genetics 2010;55(9):590-9.
2010: Shigeo Haruki; Issei Imoto; Ken-ichi Kozaki; Takeshi Matsui; Hiroshi Kawachi; Shuhei Komatsu; Tomoki Muramatsu; Yutaka Shimada; Tatsuyuki Kawano; Johji Inazawa
Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma.
Carcinogenesis 2010;31(6):1027-36.
2010: Mayuko Furuta; Ken-ich Kozaki; Shinji Tanaka; Shigeki Arii; Issei Imoto; Johji Inazawa
miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma.
Carcinogenesis 2010;31(5):766-76.
2010: Shozo Honda; Koji O Orii; Junya Kobayashi; Shin Hayashi; Atsushi Imamura; Issei Imoto; Eiji Nakagawa; Yu-ichi Goto; Johji Inazawa
Novel deletion at Xq24 including the UBE2A gene in a patient with X-linked mental retardation.
Journal of human genetics 2010;55(4):244-7.
2010: Naotaka Nishiyama; Eri Arai; Yoshitomo Chihara; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Taiji Tsukamoto; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage.
Cancer science 2010;101(1):231-40.
2009: Eri Arai; Saori Ushijima; Masahiro Gotoh; Hidenori Ojima; Tomoo Kosuge; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma.
International journal of cancer. Journal international du cancer 2009;125(12):2854-62.
2009: Takashi Kubo; Yukie Kuroda; Hiroko Shimizu; Akiko Kokubu; Naoko Okada; Fumie Hosoda; Yasuhito Arai; Yu Nakamura; Hirokazu Taniguchi; Kazuyoshi Yanagihara; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Tatsuhiro Shibata
Resequencing and copy number analysis of the human tyrosine kinase gene family in poorly differentiated gastric cancer.
Carcinogenesis 2009;30(11):1857-64.
2009: Yu Nakamura; Toshiro Migita; Fumie Hosoda; Naoko Okada; Masahiro Gotoh; Yasuhito Arai; Michiyo Fukushima; Misao Ohki; Satoshi Miyata; Kengo Takeuchi; Issei Imoto; Hitoshi Katai; Toshiharu Yamaguchi; Johji Inazawa; Setsuo Hirohashi; Yuichi Ishikawa; Tatsuhiro Shibata
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.
International journal of cancer. Journal international du cancer 2009;125(8):1859-67.
2009: Asma Begum; Issei Imoto; Ken-ichi Kozaki; Hitoshi Tsuda; Emina Suzuki; Teruo Amagasa; Johji Inazawa
Identification of PAK4 as a putative target gene for amplification within 19q13.12-q13.2 in oral squamous-cell carcinoma.
Cancer science 2009;100(10):1908-16.
2009: Shuhei Komatsu; Issei Imoto; Hitoshi Tsuda; Ken-ich Kozaki; Tomoki Muramatsu; Yutaka Shimada; Satoshi Aiko; Yutaka Yoshizumi; Daisuke Ichikawa; Eigo Otsuji; Johji Inazawa
Overexpression of SMYD2 relates to tumor cell proliferation and malignant outcome of esophageal squamous cell carcinoma.
Carcinogenesis 2009;30(7):1139-46.
2009: Takayuki Iriyama; Kohsuke Takeda; Hiromi Nakamura; Yoshifumi Morimoto; Takumi Kuroiwa; Junya Mizukami; Tsuyoshi Umeda; Takuya Noguchi; Isao Naguro; Hideki Nishitoh; Kaoru Saegusa; Kei Tobiume; Toshiki Homma; Yutaka Shimada; Hitoshi Tsuda; Satoshi Aiko; Issei Imoto; Johji Inazawa; Kazuhiro Chida; Yoshimasa Kamei; Shiro Kozuma; Yuji Taketani; Atsushi Matsuzawa; Hidenori Ichijo
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis.
The EMBO journal 2009;28(7):843-53.
2009: Eri Arai; Saori Ushijima; Hiroyuki Fujimoto; Fumie Hosoda; Tatsuhiro Shibata; Tadashi Kondo; Sana Yokoi; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Yae Kanai
Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome.
Carcinogenesis 2009;30(2):214-21.
2009: Jun Inoue; Akiko Misawa; Yukichi Tanaka; Shizuko Ichinose; Yuriko Sugino; Hajime Hosoi; Tohru Sugimoto; Issei Imoto; Johji Inazawa
Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas.
PloS one 2009;4(9):e7099.
2008: Shin Hayashi; Nobuhiko Okamoto; Yoshio Makita; Akira Hata; Issei Imoto; Johji Inazawa
Heterozygous deletion at 14q22.1-q22.3 including the BMP4 gene in a patient with psychomotor retardation, congenital corneal opacity and feet polysyndactyly.
American journal of medical genetics. Part A 2008;146A(22):2905-10.
2008: S Qi; S Mogi; Hitoshi Tsuda; Yuetsu Tanaka; K Kozaki; Issei Imoto; Johji Inazawa; S Hasegawa; Ken Omura
Expression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongue.
International journal of oral and maxillofacial surgery 2008;37(11):1047-53.
2008: Takaya Ishihara; Hitoshi Tsuda; Akiko Hotta; Ken-Ichi Kozaki; Akira Yoshida; Jaeduk Yoshimura Noh; Koichi Ito; Issei Imoto; Johji Inazawa
ITCH is a putative target for a novel 20q11.22 amplification detected in anaplastic thyroid carcinoma cells by array-based comparative genomic hybridization.
Cancer science 2008;99(10):1940-9.
2008: Shin Hayashi; Seiji Mizuno; Ohsuke Migita; Torayuki Okuyama; Yoshio Makita; Akira Hata; Issei Imoto; Johji Inazawa
The CASK gene harbored in a deletion detected by array-CGH as a potential candidate for a gene causative of X-linked dominant mental retardation.
American journal of medical genetics. Part A 2008;146A(16):2145-51.
2008: Yoko Katsuki; Shinichiro Nakada; Tetsuji Yokoyama; Issei Imoto; Johji Inazawa; Masayuki Nagasawa; Shuki Mizutani
Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes.
Cancer science 2008;99(8):1539-45.
2008: Ryoko Kikuchi; Hitoshi Tsuda; Ken-ichi Kozaki; Yae Kanai; Takahiro Kasamatsu; Kazuo Sengoku; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer.
Cancer research 2008;68(13):5067-75.
2008: Erina Nakamura; Ken-ichi Kozaki; Hitoshi Tsuda; Emina Suzuki; Atiphan Pimkhaokham; Gou Yamamoto; Tarou Irie; Tetsuhiko Tachikawa; Teruo Amagasa; Johji Inazawa; Issei Imoto
Frequent silencing of a putative tumor suppressor gene melatonin receptor 1 A (MTNR1A) in oral squamous-cell carcinoma.
Cancer science 2008;99(7):1390-400.
2008: Yasunori Saitoh; Naoki Yamamoto; Md Zahidunnabi Dewan; Haruyo Sugimoto; Vicente J Martinez Bruyn; Yuki Iwasaki; Katsuyoshi Matsubara; Xiaohua Qi; Tatsuya Saitoh; Issei Imoto; Johji Inazawa; Atae Utsunomiya; Toshiki Watanabe; Takao Masuda; Norio Yamamoto; Shoji Yamaoka
Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells.
Blood 2008;111(10):5118-29.
2008: Ayako Suzuki; Tatsuhiro Shibata; Yutaka Shimada; Yoshinori Murakami; Akira Horii; Keiko Shiratori; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.
Cancer science 2008;99(5):986-94.
2008: Ken-ichi Kozaki; Issei Imoto; Seiki Mogi; Ken Omura; Johji Inazawa
Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer.
Cancer research 2008;68(7):2094-105.
2008: C Zhao; Jun-Ichiro Inoue; Issei Imoto; T Otsuki; S Iida; R Ueda; Johji Inazawa
POU2AF1, an amplification target at 11q23, promotes growth of multiple myeloma cells by directly regulating expression of a B-cell maturation factor, TNFRSF17.
Oncogene 2008;27(1):63-75.
2007: E Suzuki; Issei Imoto; Atiphan Pimkhaokham; Takayuki Nakagawa; N Kamata; Ken-ichi Kozaki; Teruo Amagasa; Johji Inazawa
PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation.
Oncogene 2007;26(57):7921-32.
2007: Y Sugino; Akiko Misawa; Jun-Ichiro Inoue; M Kitagawa; Hajime Hosoi; Tohru Sugimoto; Issei Imoto; Johji Inazawa
Epigenetic silencing of prostaglandin E receptor 2 (PTGER2) is associated with progression of neuroblastomas.
Oncogene 2007;26(53):7401-13.
2007: Hiroto Katoh; Hidenori Ojima; Akiko Kokubu; Shigeru Saito; Tadashi Kondo; Tomoo Kosuge; Fumie Hosoda; Issei Imoto; Johji Inazawa; Setsuo Hirohashi; Tatsuhiro Shibata
Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.
Gastroenterology 2007;133(5):1475-86.
2007: Keiichi Tanaka; Issei Imoto; Jun-Ichiro Inoue; Ken-ichi Kozaki; Hitoshi Tsuda; Yutaka Shimada; Satoshi Aiko; Yutaka Yoshizumi; Takehisa Iwai; T Kawano; Johji Inazawa
Frequent methylation-associated silencing of a candidate tumor-suppressor, CRABP1, in esophageal squamous-cell carcinoma.
Oncogene 2007;26(44):6456-68.
2007: Ryoko Kikuchi; Hitoshi Tsuda; Yae Kanai; Takahiro Kasamatsu; Kazuo Sengoku; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer.
Cancer research 2007;67(15):7095-105.
2007: Tsutomu Kawasaki; Sana Yokoi; Hitoshi Tsuda; Hiroyuki Izumi; Ken-Ichi Kozaki; Shinsuke Aida; Yuichi Ozeki; Yasuyuki Yoshizawa; Issei Imoto; Johji Inazawa
BCL2L2 is a probable target for novel 14q11.2 amplification detected in a non-small cell lung cancer cell line.
Cancer science 2007;98(7):1070-7.
2007: Yasuo Shinoda; Ken-Ichi Kozaki; Issei Imoto; Wataru Obara; Hitoshi Tsuda; Yoichi Mizutani; Taro Shuin; Tomoaki Fujioka; Tsuneharu Miki; Johji Inazawa
Association of KLK5 overexpression with invasiveness of urinary bladder carcinoma cells.
Cancer science 2007;98(7):1078-86.
2007: Shin Hayashi; Masae Ono; Yoshio Makita; Issei Imoto; Shuki Mizutani; Johji Inazawa
Fortuitous detection of a submicroscopic deletion at 1q25 in a girl with Cornelia-de Lange syndrome carrying t(5;13)(p13.1;q12.1) by array-based comparative genomic hybridization.
American journal of medical genetics. Part A 2007;143A(11):1191-7.
2007: Shozo Honda; Shin Hayashi; Mitsuhiro Kato; Yo Niida; Kiyoshi Hayasaka; Torayuki Okuyama; Issei Imoto; Shuki Mizutani; Johji Inazawa
Clinical and molecular cytogenetic characterization of two patients with non-mutational aberrations of the FMR2 gene.
American journal of medical genetics. Part A 2007;143(7):687-93.
2007: Panayiotis Loukopoulos; Tatsuhiro Shibata; Hiroto Katoh; Akiko Kokubu; Michiie Sakamoto; Ken Yamazaki; Tomoo Kosuge; Yae Kanai; Fumie Hosoda; Issei Imoto; Misao Ohki; Johji Inazawa; Setsuo Hirohashi
Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome.
Cancer science 2007;98(3):392-400.
2007: K Saigusa; Issei Imoto; Chizu Tanikawa; M Aoyagi; K Ohno; Yusuke Nakamura; Johji Inazawa
RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest.
Oncogene 2007;26(8):1110-21.
2007: W Yu; Issei Imoto; Jun-Ichiro Inoue; M Onda; M Emi; Johji Inazawa
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.
Oncogene 2007;26(8):1178-87.
2007: Shin Hayashi; Shozo Honda; Maki Minaguchi; Yoshio Makita; Nobuhiko Okamoto; Rika Kosaki; Torayuki Okuyama; Issei Imoto; Shuki Mizutani; Johji Inazawa
Construction of a high-density and high-resolution human chromosome X array for comparative genomic hybridization analysis.
Journal of human genetics 2007;52(5):397-405.
2006: Ken-ichi Kozaki; Issei Imoto; Atiphan Pimkhaokham; Shogo Hasegawa; Hitoshi Tsuda; Ken Omura; Johji Inazawa
PIK3CA mutation is an oncogenic aberration at advanced stages of oral squamous cell carcinoma.
Cancer science 2006;97(12):1351-8.
2006: Hisashi Takada; Issei Imoto; Hitoshi Tsuda; Y Nakanishi; C Sakakura; Shoji Mitsufuji; Setsuo Hirohashi; Johji Inazawa
Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis.
Oncogene 2006;25(49):6554-62.
2006: Takayuki Nakagawa; Atiphan Pimkhaokham; Emina Suzuki; Ken Omura; Johji Inazawa; Issei Imoto
Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma.
Cancer science 2006;97(10):1070-4.
2006: Issei Imoto; Hiroyuki Izumi; Sana Yokoi; Hiroshi Hosoda; Tatsuhiro Shibata; Fumie Hosoda; Misao Ohki; Setsuo Hirohashi; Johji Inazawa
Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers.
Cancer research 2006;66(9):4617-26.
2006: Shinichiro Nakada; Yoko Katsuki; Issei Imoto; Tetsuji Yokoyama; Masayuki Nagasawa; Johji Inazawa; Shuki Mizutani
Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations.
The Journal of clinical investigation 2006;116(1):80-9.
2005: Hisashi Takada; Issei Imoto; Hitoshi Tsuda; Yukihiro Nakanishi; Takashi Ichikura; Hidetaka Mochizuki; Shoji Mitsufuji; Fumie Hosoda; Setsuo Hirohashi; Misao Ohki; Johji Inazawa
ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation.
Oncogene 2005;24(54):8051-60.
2005: Akiko Misawa; Jun-Ichiro Inoue; Yuriko Sugino; Hajime Hosoi; Tohru Sugimoto; Fumie Hosoda; Misao Ohki; Issei Imoto; Johji Inazawa
Methylation-associated silencing of the nuclear receptor 1I2 gene in advanced-type neuroblastomas, identified by bacterial artificial chromosome array-based methylated CpG island amplification.
Cancer research 2005;65(22):10233-42.
2005: Shin Hayashi; Kenji Kurosawa; Issei Imoto; Shuki Mizutani; Johji Inazawa
Detection of cryptic chromosome aberrations in a patient with a balanced t(1;9)(p34.2;p24) by array-based comparative genomic hybridization.
American journal of medical genetics. Part A 2005;139(1):32-6.
2005: Hiroto Katoh; Tatsuhiro Shibata; Akiko Kokubu; Hidenori Ojima; Panayiotis Loukopoulos; Yae Kanai; Tomoo Kosuge; Masashi Fukayama; Tadashi Kondo; Michiie Sakamoto; Fumie Hosoda; Misao Ohki; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.
Journal of hepatology 2005;43(5):863-74.
2005: Kuniyasu Saigusa; Naoya Hashimoto; Hitoshi Tsuda; Sana Yokoi; Motohiko Maruno; Toshiki Yoshimine; Masaru Aoyagi; Kikuo Ohno; Issei Imoto; Johji Inazawa
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Cancer science 2005;96(10):676-83.
2005: Wei-Xia Peng; Tatsuhiro Shibata; Hiroto Katoh; Akiko Kokubu; Yoshihiro Matsuno; Hisao Asamura; Ryosuke Tsuchiya; Yae Kanai; Fumie Hosoda; Tokuki Sakiyama; Misao Ohki; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.
Cancer science 2005;96(10):661-7.
2005: Tatsuhiro Shibata; Satomi Uryu; Akiko Kokubu; Fumie Hosoda; Misao Ohki; Tokuki Sakiyama; Yoshihiro Matsuno; Ryosuke Tsuchiya; Yae Kanai; Tadashi Kondo; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(17):6177-85.
2005: Hideaki Tanami; Hitoshi Tsuda; Satoshi Okabe; Takehisa Iwai; Kenichi Sugihara; Issei Imoto; Johji Inazawa
Involvement of cyclin D3 in liver metastasis of colorectal cancer, revealed by genome-wide copy-number analysis.
Laboratory investigation; a journal of technical methods and pathology 2005;85(9):1118-29.
2005: Hiroyuki Izumi; Jun-Ichiro Inoue; Sana Yokoi; Hiroshi Hosoda; Tatsuhiro Shibata; Makoto Sunamori; Setsuo Hirohashi; Johji Inazawa; Issei Imoto
Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.
Human molecular genetics 2005;14(8):997-1007.
2005: Hisashi Takada; Issei Imoto; Hitoshi Tsuda; Itaru Sonoda; Takashi Ichikura; Hidetaka Mochizuki; Takeshi Okanoue; Johji Inazawa
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer science 2005;96(2):100-10.
2004: Takahiro Sanada; Sana Yokoi; Shigeki Arii; Kohichiroh Yasui; Issei Imoto; Johji Inazawa
Skp2 overexpression is a p27Kip1-independent predictor of poor prognosis in patients with biliary tract cancers.
Cancer science 2004;95(12):969-76.
2004: Hideaki Tanami; Issei Imoto; Akira Hirasawa; Yasuhiro Yuki; Itaru Sonoda; Jun-Ichiro Inoue; Kohichiro Yasui; Akiko Misawa-Furihata; Yutaka Kawakami; Johji Inazawa
Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines.
Oncogene 2004;23(54):8796-804.
2004: Johji Inazawa; Jun-Ichiro Inoue; Issei Imoto
Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes.
Cancer science 2004;95(7):559-63.
2004: Jun-Ichiro Inoue; Takemi Otsuki; Akira Hirasawa; Issei Imoto; Yoshinobu Matsuo; Shiroh Shimizu; Masafumi Taniwaki; Johji Inazawa
Overexpression of PDZK1 within the 1q12-q22 amplicon is likely to be associated with drug-resistance phenotype in multiple myeloma.
The American journal of pathology 2004;165(1):71-81.
2004: Yasuhiro Yuki; Issei Imoto; Masue Imaizumi; Shigeyoshi Hibi; Yasuhiko Kaneko; Teruo Amagasa; Johji Inazawa
Identification of a novel fusion gene in a pre-B acute lymphoblastic leukemia with t(1;19)(q23;p13).
Cancer science 2004;95(6):503-7.
2004: Itaru Sonoda; Issei Imoto; Jun-Ichiro Inoue; Tatsuhiro Shibata; Yutaka Shimada; Koei Chin; Masayuki Imamura; Teruo Amagasa; Joe Gray; Setsuo Hirohashi; Johji Inazawa
Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.
Cancer research 2004;64(11):3741-7.
2004: Kohichiroh Yasui; Saori Mihara; Chen Zhao; Hiroyuki Okamoto; Fumiko Saito-Ohara; Akihiro Tomida; Tadao Funato; Akira Yokomizo; Seiji Naito; Issei Imoto; Takashi Tsuruo; Johji Inazawa
Alteration in copy numbers of genes as a mechanism for acquired drug resistance.
Cancer research 2004;64(4):1403-10.
2004: Akiko Misawa; Hajime Hosoi; Issei Imoto; Tomoko Iehara; Tohru Sugimoto; Johji Inazawa
Translocation (1;22)(p36;q11.2) with concurrent del(22)(q11.2) resulted in homozygous deletion of SNF5/INI1 in a newly established cell line derived from extrarenal rhabdoid tumor.
Journal of human genetics 2004;49(10):586-9.
2003: Akira Hirasawa; Daisuke Aoki; Jun-Ichiro Inoue; Issei Imoto; Nobuyuki Susumu; Kokichi Sugano; Shiro Nozawa; Johji Inazawa
Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(15):5675-82.
2003: Sana Yokoi; Kohichiroh Yasui; Toshihiko Iizasa; Issei Imoto; Takehiko Fujisawa; Johji Inazawa
TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(13):4705-13.
2003: Issei Imoto; Yasuhiro Yuki; Itaru Sonoda; Tetsuo Ito; Yutaka Shimada; Masayuki Imamura; Johji Inazawa
Identification of ZASC1 encoding a Krüppel-like zinc finger protein as a novel target for 3q26 amplification in esophageal squamous cell carcinomas.
Cancer research 2003;63(18):5691-6.
2003: Akira Hirasawa; Fumiko Saito-Ohara; Jun-Ichiro Inoue; Daisuke Aoki; Nobuyuki Susumu; Tetsuji Yokoyama; Shiro Nozawa; Johji Inazawa; Issei Imoto
Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(6):1995-2004.
2003: Fumiko Saito-Ohara; Issei Imoto; Jun-Ichiro Inoue; Hajime Hosoi; Akira Nakagawara; Tohru Sugimoto; Johji Inazawa
PPM1D is a potential target for 17q gain in neuroblastoma.
Cancer research 2003;63(8):1876-83.
2003: Wei Yu; Jun-Ichiro Inoue; Issei Imoto; Yoshinobu Matsuo; Abraham Karpas; Johji Inazawa
GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines.
Journal of human genetics 2003;48(6):331-5.
2002: Takafumi Watanabe; Issei Imoto; Tomoyuki Katahira; Akira Hirasawa; Isamu Ishiwata; Mitsuru Emi; Masaomi Takayama; Akira Sato; Johji Inazawa
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.
Japanese journal of cancer research : Gann 2002;93(10):1114-22.
2002: Issei Imoto; Hitoshi Tsuda; Akira Hirasawa; Masahiko Miura; Masaru Sakamoto; Setsuo Hirohashi; Johji Inazawa
Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy.
Cancer research 2002;62(17):4860-6.
2002: Fumiko Saito-Ohara; Yoji Fukuda; Masahiro Ito; Kishan Lal Agarwala; Masaharu Hayashi; Masafumi Matsuo; Issei Imoto; Kazuhiro Yamakawa; Yusuke Nakamura; Johji Inazawa
The Xq22 inversion breakpoint interrupted a novel Ras-like GTPase gene in a patient with Duchenne muscular dystrophy and profound mental retardation.
American journal of human genetics 2002;71(3):637-45.
2002: Kohichiroh Yasui; Shigeki Arii; Chen Zhao; Issei Imoto; Masakazu Ueda; Hisaki Nagai; Mitsuru Emi; Johji Inazawa
TFDP1, CUL4A, and CDC16 identified as targets for amplification at 13q34 in hepatocellular carcinomas.
Hepatology (Baltimore, Md.) 2002;35(6):1476-84.
2002: Koichi Nakakuki; Issei Imoto; Atiphan Pimkhaokham; Yoji Fukuda; Yutaka Shimada; Masayuki Imamura; Teruo Amagasa; Johji Inazawa
Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas.
Carcinogenesis 2002;23(1):19-24.
2001: K Yasui; Issei Imoto; Yoji Fukuda; Atiphan Pimkhaokham; ZQ Yang; T Naruto; Yutaka Shimada; Yusuke Nakamura; Johji Inazawa
Identification of target genes within an amplicon at 14q12-q13 in esophageal squamous cell carcinoma.
Genes, chromosomes & cancer 2001;32(2):112-8.
2001: Issei Imoto; ZQ Yang; Atiphan Pimkhaokham; Hitoshi Tsuda; Yutaka Shimada; Masayuki Imamura; Misao Ohki; Johji Inazawa
Identification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomas.
Cancer research 2001;61(18):6629-34.
2001: Issei Imoto; Itaru Sonoda; Yasuhiro Yuki; Johji Inazawa
Identification and characterization of human PKNOX2, a novel homeobox-containing gene.
Biochemical and biophysical research communications 2001;287(1):270-6.
2001: Issei Imoto; Atiphan Pimkhaokham; Yoji Fukuda; ZQ Yang; Yutaka Shimada; N Nomura; Hisamura Hirai; Masayuki Imamura; Johji Inazawa
SNO is a probable target for gene amplification at 3q26 in squamous-cell carcinomas of the esophagus.
Biochemical and biophysical research communications 2001;286(3):559-65.
2001: T Watanabe; Issei Imoto; Yoshinori Kosugi; I Ishiwata; S Inoue; Masaomi Takayama; A Sato; Johji Inazawa
A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.
Gynecologic oncology 2001;81(2):172-7.
2001: ZQ Yang; Issei Imoto; Atiphan Pimkhaokham; Yutaka Shimada; K Sasaki; M Oka; Johji Inazawa
A novel amplicon at 9p23 - 24 in squamous cell carcinoma of the esophagus that lies proximal to GASC1 and harbors NFIB.
Japanese journal of cancer research : Gann 2001;92(4):423-8.
2001: T Watanabe; Issei Imoto; Yoshinori Kosugi; Yoji Fukuda; J Mimura; Y Fujii; Keiichi Isaka; Masaomi Takayama; A Sato; Johji Inazawa
Human arylhydrocarbon receptor repressor (AHRR) gene: genomic structure and analysis of polymorphism in endometriosis.
Journal of human genetics 2001;46(6):342-6.
2001: N Sugimoto; Issei Imoto; Yoji Fukuda; N Kurihara; S Kuroda; A Tanigami; K Kaibuchi; R Kamiyama; Johji Inazawa
IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A.
Journal of human genetics 2001;46(1):21-5.
2000: Yoji Fukuda; N Kurihara; Issei Imoto; K Yasui; Masasuke Yoshida; K Yanagihara; J G Park; Yusuke Nakamura; Johji Inazawa
CD44 is a potential target of amplification within the 11p13 amplicon detected in gastric cancer cell lines.
Genes, chromosomes & cancer 2000;29(4):315-24.
2000: Atiphan Pimkhaokham; Yutaka Shimada; Yoji Fukuda; N Kurihara; Issei Imoto; ZQ Yang; Masayuki Imamura; Yusuke Nakamura; Teruo Amagasa; Johji Inazawa
Nonrandom chromosomal imbalances in esophageal squamous cell carcinoma cell lines: possible involvement of the ATF3 and CENPF genes in the 1q32 amplicon.
Japanese journal of cancer research : Gann 2000;91(11):1126-33.
2000: Issei Imoto; Atiphan Pimkhaokham; T Watanabe; Fumiko Saito-Ohara; E Soeda; Johji Inazawa
Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines.
Biochemical and biophysical research communications 2000;276(1):264-70.
2000: ZQ Yang; Issei Imoto; Yoji Fukuda; Atiphan Pimkhaokham; Yutaka Shimada; Masayuki Imamura; S Sugano; Yusuke Nakamura; Johji Inazawa
Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines.
Cancer research 2000;60(17):4735-9.