FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Costas Ioannides

Research Profile

Living Beings

Chemicals & Drugs

Procedures

Mutagenicity Tests

Anatomy

Physiology

Objects

Concepts & Ideas

Structure-Activity Relationship

Co-author Network

Publications

TOP 3
Ahmad Faizal Abdull Razis; Gina Rosalinda De Nicola; Renato Iori; Eleonora Pagnotta; Costas Ioannides
A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase.
Costas Ioannides
Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices.
Ahmad F Abdull Razis; Natalya Hanlon; Renato Iori; Veronika Krizova; Kathryn E Plant; Nick Plant; Ewa Soltys; Costas Ioannides
The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Costas Ioannides (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Ahmad Faizal Abdull Razis; Gina Rosalinda De Nicola; Renato Iori; Eleonora Pagnotta; Costas Ioannides
A glucosinolate-rich extract of Japanese Daikon perturbs carcinogen-metabolizing enzyme systems in rat, being a potent inducer of hepatic glutathione S-transferase.
European journal of nutrition 2013;52(3):1279-85.
2013: Costas Ioannides
Up-regulation of cytochrome P450 and phase II enzymes by xenobiotics in precision-cut tissue slices.
Xenobiotica; the fate of foreign compounds in biological systems 2013;43(1):15-28.
2012: Ahmad F Abdull Razis; Natalya Hanlon; Renato Iori; Veronika Krizova; Kathryn E Plant; Nick Plant; Ewa Soltys; Costas Ioannides
The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor.
Archives of toxicology 2012;86(10):1505-14.
2012: Ahmad F Abdull Razis; Manuela Bagatta; Gina R De Nicola; Renato Iori; Nick Plant; Costas Ioannides
Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile.
Journal of agricultural and food chemistry 2012;60(22):5556-64.
2012: Ahmad F Abdull Razis; Myrto Dervetzoglou; Nattaya Konsue; Kathryn E Plant; Nick Plant; Costas Ioannides
Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor.
Molecular nutrition & food research 2012;56(3):425-34.
2012: Ahmed Faizal Abdull Razis; Gina Rosalinda De Nicola; Renato Iori; Eleonora Pagnotta; Costas Ioannides
4-Methylsulfanyl-3-butenyl isothiocyanate derived from glucoraphasatin is a potent inducer of rat hepatic phase II enzymes and a potential chemopreventive agent.
Archives of toxicology 2012;86(2):183-94.
2011: Ahmad Faizal Abdull Razis; Manuela Bagatta; Gina Rosalinda De Nicola; Renato Iori; Costas Ioannides
Induction of epoxide hydrolase and glucuronosyl transferase by isothiocyanates and intact glucosinolates in precision-cut rat liver slices: importance of side-chain substituent and chirality.
Archives of toxicology 2011;85(8):919-27.
2011: Ahmad Faizal Abdull Razis; Renato Iori; Costas Ioannides
The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer.
International journal of cancer. Journal international du cancer 2011;128(12):2775-82.
2011: Ahmad Faizal Abdull Razis; Manuela Bagatta; Gina Rosalinda De Nicola; Renato Iori; Costas Ioannides
Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin.
Lung cancer (Amsterdam, Netherlands) 2011;71(3):298-305.
2011: Natalya Hanlon; Nattaya Konsue; Nick G Coldham; Maurice J Sauer; Costas Ioannides
Exposure to isothiocyanates suppresses urinary mutagenicity in rats treated with heterocyclic amine IQ: lack of association with CYP1 activity.
Nutrition and cancer 2011;63(2):300-5.
2010: Ahmad F Abdull Razis; Manuela Bagatta; Gina R De Nicola; Renato Iori; Costas Ioannides
Intact glucosinolates modulate hepatic cytochrome P450 and phase II conjugation activities and may contribute directly to the chemopreventive activity of cruciferous vegetables.
Toxicology 2010;277(1-3):74-85.
2010: Nattaya Konsue; Costas Ioannides
Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate.
Molecular nutrition & food research 2010;54(10):1477-85.
2010: Nattaya Konsue; Costas Ioannides
Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450.
Archives of toxicology 2010;84(10):751-9.
2010: Nattaya Konsue; Jo Kirkpatrick; Nikolai Kuhnert; Laurie J King; Costas Ioannides
Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats.
Molecular nutrition & food research 2010;54(3):426-32.
2010: Nattaya Konsue; Costas Ioannides
Modulation of carcinogen-metabolising cytochromes P450 in human liver by the chemopreventive phytochemical phenethyl isothiocyanate, a constituent of cruciferous vegetables.
Toxicology 2010;268(3):184-90.
2009: Natalya Hanlon; Nick G Coldham; Adriana Gielbert; Maurice J Sauer; Costas Ioannides
Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers.
Cancer letters 2009;284(1):15-20.
2009: Natalya Hanlon; Charlotte L Poynton; Nick G Coldham; Maurice J Sauer; Costas Ioannides
The aliphatic isothiocyanates erucin and sulforaphane do not effectively up-regulate NAD(P)H:quinone oxidoreductase (NQO1) in human liver compared with rat.
Molecular nutrition & food research 2009;53(7):836-44.
2009: Carlos Lopez-Mendez; Alexandra Bermudez-Fajardo; Costas Ioannides; Ernesto Oviedo-Orta
Effect of 2-amino-9H-pyrido[2,3-b]indole (AalphaC), a carcinogenic heterocyclic amine present in food, on atherosclerotic plaque development in apoE deficient mice.
Toxicology letters 2009;185(2):73-8.
2008: N Konsue; Costas Ioannides
Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2008;46(12):3677-83.
2008: Yvonne C M Staal; Daphnee S Pushparajah; Marcel H M van Herwijnen; Ralph W H Gottschalk; Lou M Maas; Costas Ioannides; Frederik J Van Schooten; Joost H M van Delft
Interactions between polycyclic aromatic hydrocarbons in binary mixtures: effects on gene expression and DNA adduct formation in precision-cut rat liver slices.
Mutagenesis 2008;23(6):491-9.
2008: Natalya Hanlon; Nick G Coldham; Maurice J Sauer; Costas Ioannides
Up-regulation of the CYP1 family in rat and human liver by the aliphatic isothiocyanates erucin and sulforaphane.
Toxicology 2008;252(1-3):92-8.
2008: Natalya Hanlon; Amaka Okpara; Nick G Coldham; Maurice J Sauer; Costas Ioannides
Modulation of rat hepatic and pulmonary cytochromes P450 and phase II enzyme systems by erucin, an isothiocyanate structurally related to sulforaphane.
Journal of agricultural and food chemistry 2008;56(17):7866-71.
2008: Daphnee S Pushparajah; Meera Umachandran; Kathryn E Plant; Nick Plant; Costas Ioannides
Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung.
Mutagenesis 2008;23(4):299-308.
2008: Daphnee S Pushparajah; Meera Umachandran; Kathryn E Plant; Nick Plant; Costas Ioannides
Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices.
Mutation research 2008;640(1-2):153-61.
2008: Natalya Hanlon; Nick G Coldham; Adriana Gielbert; Nikolai Kuhnert; Maurice J Sauer; Laurence J King; Costas Ioannides
Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat.
The British journal of nutrition 2008;99(3):559-64.
2008: Daphnee S Pushparajah; Meera Umachandran; Tariq Nazir; Kathryn E Plant; Nick Plant; David F V Lewis; Costas Ioannides
Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(1):128-45.
2007: Daphnee S Pushparajah; Meera Umachandran; Kathryn E Plant; Nick Plant; Costas Ioannides
Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities.
Toxicology 2007;231(1):68-80.
2007: Yvonne C M Staal; Marcel H M van Herwijnen; Daphnee S Pushparajah; Meera Umachandran; Costas Ioannides; Frederik J Van Schooten; Joost H M van Delft
Modulation of gene expression and DNA-adduct formation in precision-cut liver slices exposed to polycyclic aromatic hydrocarbons of different carcinogenic potency.
Mutagenesis 2007;22(1):55-62.
2006: Meera Umachandran; Costas Ioannides
Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h.
Toxicology 2006;224(1-2):14-21.
2006: Debra Jean Skene; Sarah E Timbers; Benita Middleton; Judie English; Caroline Kopp; Irene Tobler; Costas Ioannides
Mice convert melatonin to 6-sulphatoxymelatonin.
General and comparative endocrinology 2006;147(3):371-6.
2006: Costas Ioannides
Cytochrome p450 expression in the liver of food-producing animals.
Current drug metabolism 2006;7(4):335-48.
2005: Victoria Yoxall; Peter Kentish; Nick G Coldham; Nikolai Kuhnert; Maurice J Sauer; Costas Ioannides
Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity.
International journal of cancer. Journal international du cancer 2005;117(3):356-62.
2005: Victoria Yoxall; Meera Umachandran; Judith Wilson; Peter Kentish; Costas Ioannides
Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat.
Mutagenesis 2005;20(1):23-8.
2004: Victoria Yoxall; Jacquie Bishop; Costas Ioannides
Effect of black tea intake on the excretion of mutagens in the urine of volunteers taking a beef meal.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004;13(12):2196-202.
2004: Meera Umachandran; JA Howarth; Costas Ioannides
Metabolic and structural viability of precision-cut rat lung slices in culture.
Xenobiotica; the fate of foreign compounds in biological systems 2004;34(8):771-80.
2004: Victoria Yoxall; D A Parker; Peter Kentish; Costas Ioannides
Short-term black tea intake modulates the excretion of urinary mutagens in rats treated with 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ): role of CYP1A2 upregulation.
Archives of toxicology 2004;78(8):477-82.
2004: Victoria Yoxall; Judith Wilson; Costas Ioannides
An improved method for the extraction of mutagens from human urine and cooked meat using blue rayon.
Mutation research 2004;559(1-2):121-30.
2004: Susila Sivapathasundaram; Laurence C Howells; Maurice J Sauer; Costas Ioannides
Functional integrity of precision-cut liver slices from deer and cattle.
Journal of veterinary pharmacology and therapeutics 2004;27(2):79-84.
2004: Costas Ioannides; David F V Lewis
Cytochromes P450 in the bioactivation of chemicals.
Current topics in medicinal chemistry 2004;4(16):1767-88.
2003: Costas Ioannides; Victoria Yoxall
Antimutagenic activity of tea: role of polyphenols.
Current opinion in clinical nutrition and metabolic care 2003;6(6):649-56.
2003: Fenton Catterall; Avra I Kassimi; Michael N Clifford; Costas Ioannides
Influence of milk on the antimutagenic potential of green and black teas.
Anticancer research 2003;23(5A):3863-7.
2003: Fenton Catterall; N J McArdle; L Mitchell; A Papayanni; Michael N Clifford; Costas Ioannides
Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2003;41(8):1141-7.
2003: Fenton Catterall; Laurence J King; Michael N Clifford; Costas Ioannides
Bioavailability of dietary doses of 3H-labelled tea antioxidants (+)-catechin and (-)-epicatechin in rat.
Xenobiotica; the fate of foreign compounds in biological systems 2003;33(7):743-53.
2003: Susila Sivapathasundaram; Paraskevi Magnisali; Nick G Coldham; Laurence C Howells; Maurice J Sauer; Costas Ioannides
Cytochrome P450 expression and testosterone metabolism in the liver of deer.
Toxicology 2003;187(1):49-65.
2003: Fenton Catterall; Emma Copeland; Michael N Clifford; Costas Ioannides
Effects of black tea theafulvins on aflatoxin B(1) mutagenesis in the Ames test.
Mutagenesis 2003;18(2):145-50.
2003: Costas Ioannides
Drug-phytochemical interactions.
Inflammopharmacology 2003;11(1):7-42.
2003: David F V Lewis; Costas Ioannides; Dennis V Parke
A quantitative structure-activity relationship (QSAR) study of mutagenicity in several series of organic chemicals likely to be activated by cytochrome P450 enzymes.
Teratogenesis, carcinogenesis, and mutagenesis 2003;Suppl 1():187-93.
2003: Susila Sivapathasundaram; Maurice J Sauer; Costas Ioannides
Xenobiotic conjugation systems in deer compared with cattle and rat.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2003;134(1):169-73.
2002: Fenton Catterall; Laurence J King; Costas Ioannides
Mutagenic activity of the glutathione S-transferase substrate 1-chloro-2,4-dinitrobenzene (CDNB) in the Salmonella mutagenicity assay.
Mutation research 2002;520(1-2):119-24.
2002: Costas Ioannides
Pharmacokinetic interactions between herbal remedies and medicinal drugs.
Xenobiotica; the fate of foreign compounds in biological systems 2002;32(6):451-78.
2002: Alok Dhawan; Diana Anderson; Sonia de Pascual-Teresa; Celestino Santos-Buelga; Michael N Clifford; Costas Ioannides
Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay.
Mutation research 2002;515(1-2):39-56.
2001: Debra Jean Skene; E Papagiannidou; E Hashemi; J Snelling; David F V Lewis; M Fernandez; Costas Ioannides
Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices.
Journal of pineal research 2001;31(4):333-42.
2001: Susila Sivapathasundaram; P Magnisali; Nick G Coldham; Laurence C Howells; Maurice J Sauer; Costas Ioannides
A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.
Biochemical pharmacology 2001;62(5):635-45.
2001: Fenton Catterall; MM Coombs; Costas Ioannides; J J Sepiol; Judith Wilson
Mutagenicity of bay-region amino-substituted cyclopenta[a]phenanthrenes and 2- and 5-aminochrysene.
Mutation research 2001;492(1-2):7-11.
2001: K Walton; MM Coombs; R Walker; Costas Ioannides
The metabolism and bioactivation of agaritine and of other mushroom hydrazines by whole mushroom homogenate and by mushroom tyrosinase.
Toxicology 2001;161(3):165-77.
2000: David F V Lewis; Costas Ioannides; Dennis V Parke; R Schulte-Hermann
Quantitative structure-activity relationships in a series of endogenous and synthetic steroids exhibiting induction of CYP3A activity and hepatomegaly associated with increased DNA synthesis.
The Journal of steroid biochemistry and molecular biology 2000;74(4):179-85.
2000: E Hashemi; C Till; Costas Ioannides
Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices.
Toxicology 2000;149(2-3):51-61.
2000: Fenton Catterall; MM Coombs; Costas Ioannides; K Walton
Bioactivation of the carcinogen 11-methoxy-16, 17-dihydro-15H-cyclopenta[a]phenanthrene.
Mutation research 2000;465(1-2):85-90.
2000: K Walton; MM Coombs; Laurence J King; R Walker; Costas Ioannides
Fate of the mushroom hydrazine agaritine in the rat and mouse.
Nutrition and cancer 2000;37(1):55-64.
2000: Fenton Catterall; Jean-Marc Souquet; Véronique Cheynier; Sonia de Pascual-Teresa; Celestino Santos-Buelga; Michael N Clifford; Costas Ioannides
Differential modulation of the genotoxicity of food carcinogens by naturally occurring monomeric and dimeric polyphenolics.
Environmental and molecular mutagenesis 2000;35(2):86-98.
1999: A Bu-Abbas; Miloslav Dobrota; Emma Copeland; Michael N Clifford; R Walker; Costas Ioannides
Proliferation of hepatic peroxisomes in rats following the intake of green or black tea.
Toxicology letters 1999;109(1-2):69-76.
1999: T Marczylo; Costas Ioannides
Evidence for the presence of a microsomal NADH-dependent enzyme system that can bioactivate aromatic amines in the liver of rats and mice.
Toxicology 1999;134(2-3):127-41.
1999: N J McArdle; Michael N Clifford; Costas Ioannides
Consumption of tea modulates the urinary excretion of mutagens in rats treated with IQ. Role of caffeine.
Mutation research 1999;441(2):191-203.
1999: A Bu-Abbas; Michael N Clifford; R Walker; Costas Ioannides
Modulation of hepatic cytochrome P450 activity and carcinogen bioactivation by black and decaffeinated black tea.
Environmental toxicology and pharmacology 1999;7(1):41-7.
1999: Costas Ioannides
Effect of diet and nutrition on the expression of cytochromes P450.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(2):109-54.
1999: E Hashemi; Miloslav Dobrota; C Till; Costas Ioannides
Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures.
Xenobiotica; the fate of foreign compounds in biological systems 1999;29(1):11-25.
1998: Fenton Catterall; Emma Copeland; Michael N Clifford; Costas Ioannides
Contribution of theafulvins to the antimutagenicity of black tea: their mechanism of action.
Mutagenesis 1998;13(6):631-6.
1998: David F V Lewis; Costas Ioannides; Dennis V Parke
An improved and updated version of the compact procedure for the evaluation of P450-mediated chemical activation.
Drug metabolism reviews 1998;30(4):709-37.
1998: David F V Lewis; Costas Ioannides; Dennis V Parke
A combined COMPACT and HazardExpert study of 40 chemicals for which information on mutagenicity and carcinogenicity is known, including the results of human epidemiological studies.
Human & experimental toxicology 1998;17(10):577-86.
1998: David F V Lewis; Costas Ioannides; Dennis V Parke
Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.
Environmental health perspectives 1998;106(10):633-41.
1998: A Bu-Abbas; Michael N Clifford; R Walker; Costas Ioannides
Contribution of caffeine and flavanols in the induction of hepatic Phase II activities by green tea.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(8):617-21.
1998: T Marczylo; Costas Ioannides
The substrate specificity of the rat hepatic cytosolic arylamine oxidase catalyzing the bioactivation of aromatic amines.
Cancer letters 1998;127(1-2):141-6.
1998: A Irizar; Costas Ioannides
Marked inhibition of hepatic cytochrome P450 activity in cholesterol-induced atherosclerosis in rabbits.
Toxicology 1998;126(3):179-93.
1998: K Walton; R Walker; Costas Ioannides
Effect of baking and freeze-drying on the direct and indirect mutagenicity of extracts from the edible mushroom Agaricus bisporus.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1998;36(4):315-20.
1998: David F V Lewis; Costas Ioannides; Dennis V Parke
Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals.
Mutation research 1998;412(1):41-54.
1997: K Walton; MM Coombs; R Walker; Costas Ioannides
Bioactivation of mushroom hydrazines to mutagenic products by mammalian and fungal enzymes.
Mutation research 1997;381(1):131-9.
1997: David F V Lewis; Paul Brantom; Costas Ioannides; R Walker; Dennis V Parke
Nitrosamine carcinogenesis: rodent assays, quantitative structure-activity relationships, and human risk assessment.
Drug metabolism reviews 1997;29(4):1055-78.
1997: K Walton; MM Coombs; Fenton Catterall; R Walker; Costas Ioannides
Bioactivation of the mushroom hydrazine, agaritine, to intermediates that bind covalently to proteins and induce mutations in the Ames test.
Carcinogenesis 1997;18(8):1603-8.
1997: T Marczylo; Costas Ioannides
Induction of the rat hepatic cytosolic arylamine oxidase by a series of polychlorinated biphenyls: association with the Ah locus.
Toxicology letters 1997;92(2):81-91.
1997: Y L Cheung; David F V Lewis; T I Ridd; TJ Gray; Costas Ioannides
Diaminonaphthalenes and related aminocompounds: mutagenicity, CYP1A induction and interaction with the Ah receptor.
Toxicology 1997;118(2-3):115-27.
1996: A Bu-Abbas; X Nunez; Michael N Clifford; R Walker; Costas Ioannides
A comparison of the antimutagenic potential of green, black and decaffeinated teas: contribution of flavanols to the antimutagenic effect.
Mutagenesis 1996;11(6):597-603.
1996: David F V Lewis; Costas Ioannides; Dennis V Parke
COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP.
Environmental health perspectives 1996;104 Suppl 5():1011-6.
1996: A Patrineli; Michael N Clifford; Costas Ioannides
Contribution of phenols, quinones and reactive oxygen species to the mutagenicity of white grape juice in the Ames test.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(9):869-72.
1996: Y L Cheung; J Snelling; N N Mohammed; T J Gray; Costas Ioannides
Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity.
Toxicology and applied pharmacology 1996;139(1):203-11.
1996: A Patrineli; Michael N Clifford; R Walker; Costas Ioannides
Mutagenicity of white grape juice in the Ames test.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(6):559-62.
1995: A Irizar; C R Barnett; Peter R Flatt; Costas Ioannides
Defective expression of cytochrome P450 proteins in the liver of the genetically obese Zucker rat.
European journal of pharmacology 1995;293(4):385-93.
1995: E O Ayalogu; J Snelling; David F V Lewis; S Talwar; Michael N Clifford; Costas Ioannides
Induction of hepatic CYP1A2 by the oral administration of caffeine to rats: lack of association with the Ah locus.
Biochimica et biophysica acta 1995;1272(2):89-94.
1995: G W Boyd; MM Coombs; Costas Ioannides; David F V Lewis; J Snelling; Andreas Tsakalof
Species variation in the metabolism of 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to its 3,4-dihydrodiol, the proximate carcinogen.
Carcinogenesis 1995;16(10):2351-5.
1995: A Irizar; Costas Ioannides
Extrahepatic expression of P450 proteins in insulin-dependent diabetes mellitus.
Xenobiotica; the fate of foreign compounds in biological systems 1995;25(9):941-9.
1995: D F Lewis; Costas Ioannides; R Walker; Dennis V Parke
Quantitative structure-activity relationships and COMPACT analysis of a series of food mutagens.
Food additives and contaminants 1995;12(5):715-23.
1995: David F V Lewis; Costas Ioannides; Dennis V Parke
A quantitative structure-activity relationship study on a series of 10 para-substituted toluenes binding to cytochrome P4502B4 (CYP2B4), and their hydroxylation rates.
Biochemical pharmacology 1995;50(5):619-25.
1995: A Irizar; Costas Ioannides
Expression and inducibility of cytochrome P450 proteins belonging to families 2,3 and 4 in the rabbit aorta.
Biochemical and biophysical research communications 1995;213(3):916-21.
1995: David F V Lewis; Costas Ioannides; Dennis V Parke
A retrospective evaluation of COMPACT predictions of the outcome of NTP rodent carcinogenicity testing.
Environmental health perspectives 1995;103(2):178-84.
1995: David F V Lewis; Costas Ioannides; Dennis V Parke
Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501.
Toxicology letters 1995;76(1):39-45.
1995: G W Boyd; MM Coombs; Costas Ioannides
CYP1 induction, binding to the hepatic aromatic hydrocarbon receptor and mutagenicity of a series of 11-alkoxy cyclopenta[a]phenanthren-17-ones: a structure activity relationship.
Toxicology 1995;95(1-3):27-35.
1995: G W Boyd; Costas Ioannides; MM Coombs
The influence of dihydrodiol conformation on the metabolic activation of cyclopenta[a]phenanthrenes.
Toxicology letters 1995;75(1-3):93-100.
1995: A Bu-Abbas; Michael N Clifford; Costas Ioannides; R Walker
Stimulation of rat hepatic UDP-glucuronosyl transferase activity following treatment with green tea.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(1):27-30.
1994: David F V Lewis; Costas Ioannides; R Walker; D V Parke
Safety evaluations of food chemicals by "COMPACT". 1. A study of some acyclic terpenes.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(11):1053-9.
1994: A Bu-Abbas; Michael N Clifford; R Walker; Costas Ioannides
Selective induction of rat hepatic CYP1 and CYP4 proteins and of peroxisomal proliferation by green tea.
Carcinogenesis 1994;15(11):2575-9.
1994: J Shavila; Costas Ioannides; L J King; Dennis V Parke
Effect of high fat diet on liver microsomal oxygenations in ferret.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(11):1063-76.
1994: David F V Lewis; Brian G Lake; Costas Ioannides; Dennis V Parke
Inhibition of rat hepatic aryl hydrocarbon hydroxylase activity by a series of 7-hydroxy coumarins: QSAR studies.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(9):829-38.
1994: A Bu-Abbas; Costas Ioannides; R Walker
Evaluation of the antimutagenic potential of anthracene: in vitro and ex vivo studies.
Mutation research 1994;309(1):101-7.
1994: A Bu-Abbas; Michael N Clifford; R Walker; Costas Ioannides
Marked antimutagenic potential of aqueous green tea extracts: mechanism of action.
Mutagenesis 1994;9(4):325-31.
1994: Costas Ioannides; David F V Lewis; Dennis V Parke
The use of computers in the safety evaluation of drugs and other chemicals.
European journal of drug metabolism and pharmacokinetics 1994;19(3):225-33.
1994: Y L Cheung; S M Puddicombe; T J Gray; Costas Ioannides
Mutagenicity and CYP1A induction by azobenzenes correlates with their carcinogenicity.
Carcinogenesis 1994;15(6):1257-63.
1994: David F V Lewis; Costas Ioannides; Dennis V Parke
Molecular modelling of cytochrome CYP1A1: a putative access channel explains differences in induction potency between the isomers benzo(a)pyrene and benzo(e)pyrene, and 2- and 4-acetylaminofluorene.
Toxicology letters 1994;71(3):235-43.
1994: David F V Lewis; Costas Ioannides; Dennis V Parke
Interaction of a series of nitriles with the alcohol-inducible isoform of P450: computer analysis of structure-activity relationships.
Xenobiotica; the fate of foreign compounds in biological systems 1994;24(5):401-8.
1994: T Marczylo; Costas Ioannides
Bioactivation of 6-aminochrysene by animal and human hepatic preparations: contributions of microsomal and cytosolic enzyme systems.
Mutagenesis 1994;9(3):233-9.
1994: C R Barnett; Peter R Flatt; Costas Ioannides
Modulation of the rat hepatic cytochrome P450 composition by long-term streptozotocin-induced insulin-dependent diabetes.
Journal of biochemical toxicology 1994;9(2):63-9.
1994: E Rekka; E O Ayalogu; David F V Lewis; G Gordon Gibson; Costas Ioannides
Induction of hepatic microsomal CYP4A activity and of peroxisomal beta-oxidation by two non-steroidal anti-inflammatory drugs.
Archives of toxicology 1994;68(2):73-8.
1994: David F V Lewis; H Moereels; Brian G Lake; Costas Ioannides; Dennis V Parke
Molecular modeling of enzymes and receptors involved in carcinogenesis: QSARs and compact-3D.
Drug metabolism reviews 1994;26(1-2):261-85.
1994: Dennis V Parke; Costas Ioannides
The effects of nutrition on chemical toxicity.
Drug metabolism reviews 1994;26(4):739-65.
1993: G W Boyd; R J Young; R G Harvey; MM Coombs; Costas Ioannides
Cytochrome P450-dependent metabolism and mutagenicity of 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one and their implications in its carcinogenicity.
Carcinogenesis 1993;14(9):1783-8.
1993: G W Boyd; H H Zepik; L M King; Costas Ioannides; MM Coombs
The in vitro metabolic activation of the 11-trifluoromethyl analogue of the potent carcinogen 15,16-dihydro-11-methyl-cyclopenta[a]-phenanthren-17-one to mutagens.
Carcinogenesis 1993;14(8):1697-9.
1993: C Papaparaskeva-Petrides; Costas Ioannides; R Walker
Contribution of phenolic and quinonoid structures in the mutagenicity of the edible mushroom Agaricus bisporus.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(8):561-7.
1993: P T Liu; Costas Ioannides; A M Symons; Dennis V Parke
Role of tissue glutathione in prevention of surgical trauma.
Xenobiotica; the fate of foreign compounds in biological systems 1993;23(8):899-911.
1993: Y L Cheung; T J Gray; Costas Ioannides
Mutagenicity of chrysene, its methyl and benzo derivatives, and their interactions with cytochromes P-450 and the Ah-receptor; relevance to their carcinogenic potency.
Toxicology 1993;81(1):69-86.
1993: Costas Ioannides; Y L Cheung; J Wilson; David F V Lewis; T J Gray
The mutagenicity and interactions of 2- and 4-(acetylamino)fluorene with cytochrome P450 and the aromatic hydrocarbon receptor may explain the difference in their carcinogenic potency.
Chemical research in toxicology 1993;6(4):535-41.
1993: C Papaparaskeva-Petrides; Costas Ioannides; G W Boyd; R J Young; R G Harvey; MM Coombs
The mutagenicity of chemically synthesized metabolites of 16,17-dihydro-15H-cyclopenta[a]phenanthrene and its carcinogenic 11-methyl homologue.
Mutagenesis 1993;8(4):307-10.
1993: G W Boyd; R J Young; R G Harvey; MM Coombs; Costas Ioannides
The metabolism and activation of 15,16-dihydrocyclopenta[a]phenanthren-17-one by cytochrome P-450 proteins.
European journal of pharmacology 1993;228(5-6):275-82.
1993: P T Liu; Costas Ioannides; J Shavila; A M Symons; Dennis V Parke
Effects of ether anaesthesia and fasting on various cytochromes P450 of rat liver and kidney.
Biochemical pharmacology 1993;45(4):871-7.
1993: David F V Lewis; Costas Ioannides; Dennis V Parke
Validation of a novel molecular orbital approach (COMPACT) for the prospective safety evaluation of chemicals, by comparison with rodent carcinogenicity and Salmonella mutagenicity data evaluated by the U.S. NCI/NTP.
Mutation research 1993;291(1):61-77.
1993: C R Barnett; S Rudd; Peter R Flatt; Costas Ioannides
Sex differences in the diabetes-induced modulation of rat hepatic cytochrome P450 proteins.
Biochemical pharmacology 1993;45(2):313-9.
1993: Costas Ioannides; Dennis V Parke
Induction of cytochrome P4501 as an indicator of potential chemical carcinogenesis.
Drug metabolism reviews 1993;25(4):485-501.
1993: Costas Ioannides; Andrew Ayrton; David F V Lewis; R Walker
Extrapolation of in vitro antimutagenicity to the in vivo situation: the case for anthraflavic acid.
Basic life sciences 1993;61():103-10.
1992: C R Barnett; L Petrides; J Wilson; Peter R Flatt; Costas Ioannides
Induction of rat hepatic mixed-function oxidases by acetone and other physiological ketones: their role in diabetes-induced changes in cytochrome P450 proteins.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(12):1441-50.
1992: J Shavila; Costas Ioannides; L J King; Dennis V Parke
Hepatic mixed-function oxidases of ferret.
Xenobiotica; the fate of foreign compounds in biological systems 1992;22(8):1003-14.
1992: C R Barnett; R A Abbott; C J Bailey; Peter R Flatt; Costas Ioannides
Cytochrome P-450-dependent mixed-function oxidase and glutathione S-transferase activities in spontaneous obesity-diabetes.
Biochemical pharmacology 1992;43(8):1868-71.
1992: Andrew Ayrton; David F V Lewis; R Walker; Costas Ioannides
Antimutagenicity of ellagic acid towards the food mutagen IQ: investigation into possible mechanisms of action.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(4):289-95.
1992: C R Barnett; J Wilson; C R Wolf; Peter R Flatt; Costas Ioannides
Hyperinsulinaemia causes a preferential increase in hepatic P4501A2 activity.
Biochemical pharmacology 1992;43(6):1255-61.
1992: E Papavergou; Costas Ioannides; Michael N Clifford
The evaluation in the Ames test of the mutagenicity of tetrahydro-beta-carboline-3-carboxylic acids from smoked foods.
Food additives and contaminants 1992;9(2):183-7.
1992: M Leist; Andrew Ayrton; Costas Ioannides
A cytosolic oxygenase activity involved in the bioactivation of 2-aminofluorene.
Toxicology 1992;71(1-2):7-20.
1992: Andrew Ayrton; S Neville; Costas Ioannides
Cytosolic activation of 2-aminoanthracene: implications in its use as diagnostic mutagen in the Ames test.
Mutation research 1992;265(1):1-8.
1991: Andrew Ayrton; Costas Ioannides; Dennis V Parke
Induction of the cytochrome P450 I and IV families and peroxisomal proliferation in the liver of rats treated with benoxaprofen. Possible implications in its hepatotoxicity.
Biochemical pharmacology 1991;42(1):109-15.
1991: Dennis V Parke; Costas Ioannides; D F Lewis
The 1990 Pharmaceutical Manufacturers Association of Canada keynote lecture. The role of the cytochromes P450 in the detoxication and activation of drugs and other chemicals.
Canadian journal of physiology and pharmacology 1991;69(5):537-49.
1991: C Papaparaskeva; Costas Ioannides; R Walker
Agaritine does not mediate the mutagenicity of the edible mushroom Agaricus bisporus.
Mutagenesis 1991;6(3):213-7.
1990: David F V Lewis; Costas Ioannides; Dennis V Parke
A retrospective study of the molecular toxicology of benoxaprofen.
Toxicology 1990;65(1-2):33-47.
1990: David F V Lewis; Costas Ioannides; Dennis V Parke
A prospective toxicity evaluation (COMPACT) on 40 chemicals currently being tested by the National Toxicology Program.
Mutagenesis 1990;5(5):433-5.
1990: C R Barnett; Peter R Flatt; Costas Ioannides
Induction of hepatic microsomal P450 I and IIB proteins by hyperketonaemia.
Biochemical pharmacology 1990;40(2):393-7.
1990: C R Barnett; G G Gibson; C R Wolf; Peter R Flatt; Costas Ioannides
Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes.
The Biochemical journal 1990;268(3):765-9.
1990: Costas Ioannides; Andrew Ayrton; A Keele; David F V Lewis; Peter R Flatt; R Walker
Mechanism of the in vitro antimutagenic action of retinol.
Mutagenesis 1990;5(3):257-62.
1990: Andrew Ayrton; M McFarlane; R Walker; S Neville; Costas Ioannides
The induction of P450 I proteins by aromatic amines may be related to their carcinogenic potential.
Carcinogenesis 1990;11(5):803-9.
1990: Dennis V Parke; Costas Ioannides; David F V Lewis
Computer modelling and in vitro tests in the safety evaluation of chemicals-Strategic applications.
Toxicology in vitro : an international journal published in association with BIBRA 1990;4(4-5):680-5.
1990: J N Smith; Andrew Ayrton; J Chown; David F V Lewis; Costas Ioannides
Feprazone: an inducer of the P450 II B family of proteins in the rat.
Journal of biochemical toxicology 1990;5(1):9-12.
1990: Andrew Ayrton; M McFarlane; R Walker; S Neville; MM Coombs; Costas Ioannides
Induction of the P-450 I family of proteins by polycyclic aromatic hydrocarbons: possible relationship to their carcinogenicity.
Toxicology 1990;60(1-2):173-86.
1990: E Ah-Sing; T W Poole; Costas Ioannides; L J King
Mechanism of the ketoconazole-cyclosporin interaction.
Archives of toxicology 1990;64(6):511-3.
1990: Costas Ioannides; Dennis V Parke
The cytochrome P450 I gene family of microsomal hemoproteins and their role in the metabolic activation of chemicals.
Drug metabolism reviews 1990;22(1):1-85.
1990: Dennis V Parke; Costas Ioannides
Role of cytochromes P-450 in mouse liver tumor production.
Progress in clinical and biological research 1990;331():215-30.
1990: C R Barnett; Peter R Flatt; Costas Ioannides
Hyperketonaemia markedly modulates the metabolic activation of chemical carcinogens.
Chemico-biological interactions 1990;74(3):281-9.
1990: Dennis V Parke; Costas Ioannides; David F V Lewis; M J Obrebska-Parke
Current problems in the evaluation of chemical safety.
Polish journal of occupational medicine 1990;3(1):15-41.
1989: Costas Ioannides; A D Rodrigues; Andrew Ayrton; C R Barnett; J Chown; Dennis V Parke
Induction of the rat hepatic microsomal mixed-function oxidases by cimetidine.
Toxicology letters 1989;49(1):61-8.
1989: Costas Ioannides; David F V Lewis; J Trinick; S Neville; N N Sertkaya; Mahmud Kajbaf; John W Gorrod
A rationale for the non-mutagenicity of 2- and 3-aminobiphenyls.
Carcinogenesis 1989;10(8):1403-7.
1989: A D Rodrigues; Andrew Ayrton; E J Williams; David F V Lewis; R Walker; Costas Ioannides
Preferential induction of the rat hepatic P450 I proteins by the food carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline.
European journal of biochemistry / FEBS 1989;181(3):627-31.
1989: Andrew Ayrton; E J Williams; A D Rodrigues; Costas Ioannides; R Walker
The food pyrolysis product IQ enhances its own activation.
Mutagenesis 1989;4(3):205-7.
1989: Peter R Flatt; O Shibier; Costas Ioannides; S K Swanston-Flatt
Studies on the chemical and immunological destruction of insulin-secreting islet cell tumours.
Experimental and clinical endocrinology 1989;93(2-3):193-202.
1989: C E Phillipson; Costas Ioannides
Metabolic activation of polycyclic aromatic hydrocarbons to mutagens in the Ames test by various animal species including man.
Mutation research 1989;211(1):147-51.
1989: Peter R Flatt; S L Bass; Andrew Ayrton; J Trinick; Costas Ioannides
Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats.
Diabetologia 1989;32(2):135-9.
1989: David F V Lewis; Costas Ioannides; Dennis V Parke
Molecular orbital studies of oxygen activation and mechanisms of cytochromes P-450-mediated oxidative metabolism of xenobiotics.
Chemico-biological interactions 1989;70(3-4):263-80.
1989: S Neville; Josephine Arendt; Costas Ioannides
A study of the mutagenicity of melatonin and 6-hydroxymelatonin.
Journal of pineal research 1989;6(1):73-6.
1989: David F V Lewis; Costas Ioannides; Dennis V Parke
Prediction of chemical carcinogenicity from molecular and electronic structures: a comparison of MINDO/3 and CNDO/2 molecular orbital methods.
Toxicology letters 1989;45(1):1-13.
1989: David F V Lewis; A D Rodrigues; Costas Ioannides; Dennis V Parke
Adverse reactions of imidazole antifungal agents: computer graphic studies of cytochrome P-450 interactions.
Journal of biochemical toxicology 1989;4(4):231-4.
1989: I W Taylor; Costas Ioannides; Dennis V Parke
Organic nitrate reductase: reassessment of its subcellular localization and tissue distribution and its relationship to the glutathione transferases.
The International journal of biochemistry 1989;21(1):67-71.
1988: Andrew Ayrton; J Trinick; B P Wood; J N Smith; Costas Ioannides
Induction of the rat hepatic microsomal mixed-function oxidases by two aza-arenes. A comparison with their non-heterocyclic analogues.
Biochemical pharmacology 1988;37(23):4565-71.
1988: C R Barnett; Peter R Flatt; Costas Ioannides
Role of ketone bodies in the diabetes-induced changes in hepatic mixed-function oxidase activities.
Biochimica et biophysica acta 1988;967(2):250-4.
1988: Andrew Ayrton; Costas Ioannides; R Walker
Induction of rat hepatic cytochrome P-450 I proteins by the antimutagen anthraflavic acid.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1988;26(11-12):909-15.
1988: Dennis V Parke; Costas Ioannides; David F V Lewis
Metabolic activation of carcinogens and toxic chemicals.
Human toxicology 1988;7(5):397-404.
1988: A D Rodrigues; P R Waddell; E Ah-Sing; B A Morris; C R Wolf; Costas Ioannides
Induction of the rat hepatic microsomal mixed-function oxidases by 3 imidazole-containing antifungal agents: selectivity for the cytochrome P-450IIB and P-450III families of cytochromes P-450.
Toxicology 1988;50(3):283-301.
1988: A D Rodrigues; P R Waddell; Costas Ioannides
Inhibition of the rat hepatic mixed-function oxidases by in vivo administration of clotrimazole.
Research communications in chemical pathology and pharmacology 1988;59(3):403-6.
1988: Andrew Ayrton; Costas Ioannides; R Walker
Anthraflavic acid inhibits the mutagenicity of the food mutagen IQ: mechanism of action.
Mutation research 1988;207(3-4):121-5.
1988: E O Ayalogu; C E Phillipson; N Preece; Costas Ioannides; Dennis V Parke
Effect of vitamin A on rat hepatic mixed-function oxidases, glutathione transferase activity and generations of oxygen radicals.
Annals of nutrition & metabolism 1988;32(2):75-82.
1988: Costas Ioannides; S L Bass; Andrew Ayrton; J Trinick; R Walker; Peter R Flatt
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
Chemico-biological interactions 1988;68(3-4):189-202.
1987: Andrew Ayrton; David F V Lewis; Costas Ioannides; R Walker
Anthraflavic acid is a potent and specific inhibitor of cytochrome P-448 activity.
Biochimica et biophysica acta 1987;916(3):328-31.
1987: A D Rodrigues; G Gordon Gibson; Costas Ioannides; Dennis V Parke
Interactions of imidazole antifungal agents with purified cytochrome P-450 proteins.
Biochemical pharmacology 1987;36(24):4277-81.
1987: Costas Ioannides; Dennis V Parke
The cytochromes P-448--a unique family of enzymes involved in chemical toxicity and carcinogenesis.
Biochemical pharmacology 1987;36(24):4197-207.
1987: Andrew Ayrton; J N Smith; Costas Ioannides
Bioactivation of N-nitrosopiperidine to mutagens: role of hepatic cytochrome P-450 proteins and contribution of cytosolic fraction.
Carcinogenesis 1987;8(11):1691-5.
1987: A D Rodrigues; David F V Lewis; Costas Ioannides; Dennis V Parke
Spectral and kinetic studies of the interaction of imidazole anti-fungal agents with microsomal cytochromes P-450.
Xenobiotica; the fate of foreign compounds in biological systems 1987;17(11):1315-27.
1987: R Hyde; J N Smith; Costas Ioannides
Induction of the hepatic mixed-function oxidases by Aroclor 1254 in the hamster: comparison of Aroclor-induced rat and hamster preparations in the activation of pre-carcinogens in the Ames test.
Mutagenesis 1987;2(6):477-82.
1987: J N Smith; Costas Ioannides
Cytosolic potentiation of the rat hepatic microsome mediated mutagenicity of benzidine.
Mutagenesis 1987;2(3):205-9.
1987: David F V Lewis; Costas Ioannides; Dennis V Parke
Structural requirements for substrates of cytochromes P-450 and P-448.
Chemico-biological interactions 1987;64(1-2):39-60.
1987: A Abu-Shakra; Costas Ioannides; R Walker
Effect of tryptamine on the mutagenic activity of 2-amino-3-methylimidazo(4,5-f) quinoline (IQ) and related azaarenes in the Ames test.
Mutagenesis 1987;2(1):51-6.
1986: A Abu-Shakra; Costas Ioannides; R Walker
Metabolic activation of 2-amino-3-methylimidazo(4,5-f)quinoline by hepatic preparations--contribution of the cytosolic fraction and its significance to strain differences.
Mutagenesis 1986;1(5):367-70.