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Michael Aviram

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Chemicals & Drugs

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Publications

TOP 3
Saar Aharoni; Michael Aviram; Bianca Fuhrman
Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.
Mira Rosenblat; N Volkova; A Elias; Michael Aviram
Monocyte-macrophage membrane possesses free radicals scavenging activity: stimulation by polyphenols or by paraoxonase 1 (PON1).
Mira Rosenblat; Nina Volkova; Nicole Paland; Michael Aviram
Triglyceride accumulation in macrophages upregulates paraoxonase 2 (PON2) expression via ROS-mediated JNK/c-Jun signaling pathway activation.

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All Publications

2013: Saar Aharoni; Michael Aviram; Bianca Fuhrman
Paraoxonase 1 (PON1) reduces macrophage inflammatory responses.
Atherosclerosis 2013;228(2):353-61.
2013: Mira Rosenblat; N Volkova; A Elias; Michael Aviram
Monocyte-macrophage membrane possesses free radicals scavenging activity: stimulation by polyphenols or by paraoxonase 1 (PON1).
Free radical research 2013;47(4):257-67.
2012: Mira Rosenblat; Nina Volkova; Nicole Paland; Michael Aviram
Triglyceride accumulation in macrophages upregulates paraoxonase 2 (PON2) expression via ROS-mediated JNK/c-Jun signaling pathway activation.
BioFactors (Oxford, England) 2012;38(6):458-69.
2012: Mira Rosenblat; Nina Volkova; Sarah Ward; Tony Hayek; Michael Aviram
VLDL triglycerides inhibit HDL-associated paraoxonase 1 (PON1) activity: in vitro and in vivo studies.
BioFactors (Oxford, England) 2012;38(4):292-9.
2012: Aviva Gamliel-Lazarovich; Zaid Abassi; Michael Aviram; Soliman Khatib; Hagai Tavori; Jacob Vaya; Shlomo Keidar
Paraoxonase1 deficiency in mice is associated with hypotension and increased levels of 5,6-epoxyeicosatrienoic acid.
Atherosclerosis 2012;222(1):92-8.
2012: Jasmin Khateeb; Yulia Kiyan; Sergey Tkachuk; Michael Aviram; Inna Dumler; Bianca Fuhrman
Urokinase-type plasminogen activator downregulates paraoxonase 1 expression in hepatocytes by stimulating peroxisome proliferator-activated receptor-γ nuclear export.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(2):449-58.
2012: Michael Aviram; Mira Rosenblat
Pomegranate Protection against Cardiovascular Diseases.
Evidence-based complementary and alternative medicine : eCAM 2012;2012():382763.
2012: Michael Aviram
Introduction to paraoxonases.
Journal of lipids 2012;2012():687273.
2011: Marie Koren-Gluzer; Edna Meilin; Michael Aviram; Tony Hayek
The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release.
Atherosclerosis 2011;219(2):510-8.
2011: Mira Rosenblat; Nina Volkova; John Ward; Michael Aviram
Paraoxonase 1 (PON1) inhibits monocyte-to-macrophage differentiation.
Atherosclerosis 2011;219(1):49-56.
2011: Jordi Camps; Lucio G Costa; Dragomir I Draganov; Antonio Hernández; Sven Horke; Richard James; Jorge Joven; Bharti Mackness; Michael Mackness; Mohamed Navab; György Paragh; Srinivasa Reddy; Daniel Rochu; Ildikó Seres; Diana Shih; Dan Tawfik; Michael Aviram
Paraoxonase-1 and clopidogrel efficacy.
Nature medicine 2011;17(9):1041-2; author reply 1042-4.
2011: Hagai Tavori; Michael Aviram; Soliman Khatib; Ramadan Musa; Dalit Mannheim; Ron Karmeli; Jacob Vaya
Paraoxonase 1 protects macrophages from atherogenicity of a specific triglyceride isolated from human carotid lesion.
Free radical biology & medicine 2011;51(1):234-42.
2011: Mira Rosenblat; Michael Aviram
Pomegranate juice protects macrophages from triglyceride accumulation: inhibitory effect on DGAT1 activity and on triglyceride biosynthesis.
Annals of nutrition & metabolism 2011;58(1):1-9.
2011: Hagai Tavori; Michael Aviram; Soliman Khatib; Ramadan Musa; Dalit Mannheim; Ron Karmeli; Jacob Vaya
Human carotid lesion linoleic acid hydroperoxide inhibits paraoxonase 1 (PON1) activity via reaction with PON1 free sulfhydryl cysteine 284.
Free radical biology & medicine 2011;50(1):148-56.
2010: Mira Rosenblat; Nina Volkova; Michael Aviram
Macrophage endoplasmic reticulum (ER) proteins and reducing elements stabilize paraoxonase 2 (PON2).
Atherosclerosis 2010;213(2):408-14.
2010: Mira Rosenblat; Nina Volkova; Michael Aviram
Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2.
Atherosclerosis 2010;212(1):86-92.
2010: Aviva Gamliel-Lazarovich; Anna Gantman; Maayan Shiner; Raymond Coleman; Michael Aviram; Shlomo Keidar
Paraoxonase 1 deficiency in mice is associated with reduced steroid biosynthesis: effects on HDL binding, cholesteryl ester accumulation and scavenger receptor type BI expression.
Atherosclerosis 2010;211(1):130-5.
2010: Bianca Fuhrman; Anna Gantman; Michael Aviram
Paraoxonase 1 (PON1) deficiency in mice is associated with reduced expression of macrophage SR-BI and consequently the loss of HDL cytoprotection against apoptosis.
Atherosclerosis 2010;211(1):61-8.
2010: Marielle Kaplan; Yvgeny Tendler; Riad Mahamid; Maayan Shiner; Michael Aviram; Tony Hayek
High glucose upregulates C-reactive protein synthesis in macrophages.
Clinical chemistry 2010;56(6):1036-8.
2010: Mira Rosenblat; Nina Volkova; Manuel Roqueta-Rivera; Manabu T Nakamura; Michael Aviram
Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid.
Atherosclerosis 2010;210(2):414-21.
2010: Michael Aviram
Atherosclerosis: cell biology and lipoproteins--oxidative stress and paraoxonases regulate atherogenesis.
Current opinion in lipidology 2010;21(2):163-4.
2010: Bianca Fuhrman; Nina Volkova; Michael Aviram
Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients.
Nutrition (Burbank, Los Angeles County, Calif.) 2010;26(4):359-66.
2010: Leonid Gaidukov; R I Viji; Shiri Yacobson; Mira Rosenblat; Michael Aviram; Dan S Tawfik
ApoE induces serum paraoxonase PON1 activity and stability similar to ApoA-I.
Biochemistry 2010;49(3):532-8.
2010: Michal Efrat; Michael Aviram
Paraoxonase 1 interactions with HDL, antioxidants and macrophages regulate atherogenesis - a protective role for HDL phospholipids.
Advances in experimental medicine and biology 2010;660():153-66.
2010: Hagai Tavori; Jacob Vaya; Michael Aviram
Paraoxonase 1 attenuates human plaque atherogenicity: relevance to the enzyme lactonase activity.
Advances in experimental medicine and biology 2010;660():99-111.
2010: Anna Gantman; Bianca Fuhrman; Michael Aviram; Tony Hayek
High glucose stimulates macrophage SR-BI expression and induces a switch in its activity from cholesterol efflux to cholesterol influx.
Biochemical and biophysical research communications 2010;391(1):523-8.
2010: Jasmin Khateeb; Anna Gantman; Adam J Kreitenberg; Michael Aviram; Bianca Fuhrman
Paraoxonase 1 (PON1) expression in hepatocytes is upregulated by pomegranate polyphenols: a role for PPAR-gamma pathway.
Atherosclerosis 2010;208(1):119-25.
2009: Bianca Fuhrman; Anna Gantman; Jasmin Khateeb; Nina Volkova; Sven Horke; Julia Kiyan; Inna Dumler; Michael Aviram
Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta.
Cardiovascular research 2009;84(1):145-54.
2009: Wasseem Rock; Mira Rosenblat; Hamutal Borochov-Neori; Nina Volkova; Sylvie Judeinstein; Mazen Elias; Michael Aviram
Effects of date ( Phoenix dactylifera L., Medjool or Hallawi Variety) consumption by healthy subjects on serum glucose and lipid levels and on serum oxidative status: a pilot study.
Journal of agricultural and food chemistry 2009;57(17):8010-7.
2009: Olga Khersonsky; Mira Rosenblat; Lilly Toker; Shiri Yacobson; Adrian Hugenmatter; Israel Silman; Joel Sussman; Michael Aviram; Dan S Tawfik
Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.
Biochemistry 2009;48(28):6644-54.
2009: Michael Aviram
Hyperlipidaemia and cardiovascular disease: inflammation and oxidative stress in diabetic patients.
Current opinion in lipidology 2009;20(3):258-9.
2009: Mira Rosenblat; Raymond Coleman; Srinivasa T Reddy; Michael Aviram
Paraoxonase 2 attenuates macrophage triglyceride accumulation via inhibition of diacylglycerol acyltransferase 1.
Journal of lipid research 2009;50(5):870-9.
2009: Michal Efrat; Mira Rosenblat; Saeed Mahmood; Jacob Vaya; Michael Aviram
Di-oleoyl phosphatidylcholine (PC-18:1) stimulates paraoxonase 1 (PON1) enzymatic and biological activities: in vitro and in vivo studies.
Atherosclerosis 2009;202(2):461-9.
2009: Mira Rosenblat; Michael Aviram
Paraoxonases role in the prevention of cardiovascular diseases.
BioFactors (Oxford, England) 2009;35(1):98-104.
2008: Hamutal Borochov-Neori; Sylvie Judeinstein; Amnon Greenberg; Bianca Fuhrman; Judith Attias; Nina Volkova; Tony Hayek; Michael Aviram
Phenolic antioxidants and antiatherogenic effects of Marula (Sclerocarrya birrea Subsp. caffra) fruit juice in healthy humans.
Journal of agricultural and food chemistry 2008;56(21):9884-91.
2008: Michal Efrat; Michael Aviram
Macrophage paraoxonase 1 (PON1) binding sites.
Biochemical and biophysical research communications 2008;376(1):105-10.
2008: Marielle Kaplan; Rachel Kerry; Michael Aviram; Tony Hayek
High glucose concentration increases macrophage cholesterol biosynthesis in diabetes through activation of the sterol regulatory element binding protein 1 (SREBP1): inhibitory effect of insulin.
Journal of cardiovascular pharmacology 2008;52(4):324-32.
2008: Rabea Asleh; Shany Blum; Shiri Kalet-Litman; Jonia Alshiek; Rachel Miller-Lotan; Roy Asaf; Wasseem Rock; Michael Aviram; Uzi Milman; Chen Shapira; Zaid Abassi; Andrew P Levy
Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype.
Diabetes 2008;57(10):2794-800.
2008: Wasseem Rock; Mira Rosenblat; Rachel Miller-Lotan; Andrew P Levy; Mazen Elias; Michael Aviram
Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities.
Journal of agricultural and food chemistry 2008;56(18):8704-13.
2008: Hagai Tavori; Soliman Khatib; Michael Aviram; Jacob Vaya
Characterization of the PON1 active site using modeling simulation, in relation to PON1 lactonase activity.
Bioorganic & medicinal chemistry 2008;16(15):7504-9.
2008: Mira Rosenblat; Nina Volkova; Raymond Coleman; Yaron Almagor; Michael Aviram
Antiatherogenicity of extra virgin olive oil and its enrichment with green tea polyphenols in the atherosclerotic apolipoprotein-E-deficient mice: enhanced macrophage cholesterol efflux.
The Journal of nutritional biochemistry 2008;19(8):514-23.
2008: Bianca Fuhrman; Jasmin Khateeb; Maayan Shiner; Orna Nitzan; Rachel Karry; Nina Volkova; Michael Aviram
Urokinase plasminogen activator upregulates paraoxonase 2 expression in macrophages via an NADPH oxidase-dependent mechanism.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(7):1361-7.
2008: Orit Rozenberg; Maayan Shiner; Michael Aviram; Tony Hayek
Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties.
Free radical biology & medicine 2008;44(11):1951-9.
2008: Navindra P Seeram; Michael Aviram; Yanjun Zhang; Susanne M Henning; Lydia Feng; Mark Dreher; David Heber
Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States.
Journal of agricultural and food chemistry 2008;56(4):1415-22.
2008: Michael Aviram; Nina Volkova; Raymond Coleman; Mark Dreher; Muntha Kesava Reddy; Daneel Ferreira; Mira Rosenblat
Pomegranate phenolics from the peels, arils, and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein e-deficient (E 0) mice and in vitro in cultured macrophages and lipoproteins.
Journal of agricultural and food chemistry 2008;56(3):1148-57.
2008: Andrea Szuchman; Michael Aviram; Ramadan Musa; Soliman Khatib; Jacob Vaya
Characterization of oxidative stress in blood from diabetic vs. hypercholesterolaemic patients, using a novel synthesized marker.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2008;13(1):119-31.
2008: Bianca Fuhrman; Ayelet Partoush; Nina Volkova; Michael Aviram
Ox-LDL induces monocyte-to-macrophage differentiation in vivo: Possible role for the macrophage colony stimulating factor receptor (M-CSF-R).
Atherosclerosis 2008;196(2):598-607.
2008: Adi Haber; Atif Mahammed; Bianca Fuhrman; Nina Volkova; Raymond Coleman; Tony Hayek; Michael Aviram; Zeev Gross
Amphiphilic/Bipolar metallocorroles that catalyze the decomposition of reactive oxygen and nitrogen species, rescue lipoproteins from oxidative damage, and attenuate atherosclerosis in mice.
Angewandte Chemie (International ed. in English) 2008;47(41):7896-900.
2007: Maayan Shiner; Bianca Fuhrman; Michael Aviram
Macrophage paraoxonase 2 (PON2) expression is upregulated by unesterified cholesterol through activation of the phosphatidylinositol 3-kinase (PI3K) pathway.
Biological chemistry 2007;388(12):1353-8.
2007: Bianca Fuhrman; Orna Nitzan; Rachel Karry; Nina Volkova; Inna Dumler; Michael Aviram
Urokinase plasminogen activator (uPA) stimulates cholesterol biosynthesis in macrophages through activation of SREBP-1 in a PI3-kinase and MEK-dependent manner.
Atherosclerosis 2007;195(2):e108-16.
2007: Mira Rosenblat; Nina Volkova; Raymond Coleman; Michael Aviram
Anti-oxidant and anti-atherogenic properties of liposomal glutathione: studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice.
Atherosclerosis 2007;195(2):e61-8.
2007: Maayan Shiner; Bianca Fuhrman; Michael Aviram
Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation.
Atherosclerosis 2007;195(2):313-21.
2007: Tony Hayek; Marielle Kaplan; Rachel Kerry; Michael Aviram
Macrophage NADPH oxidase activation, impaired cholesterol fluxes, and increased cholesterol biosynthesis in diabetic mice: a stimulatory role for D-glucose.
Atherosclerosis 2007;195(2):277-86.
2007: Bianca Fuhrman; Dorit Plat; Yael Herzog; Michael Aviram
Consumption of a novel dietary formula of plant sterol esters of canola oil fatty acids, in a canola oil matrix containing 1,3-diacylglycerol, reduces oxidative stress in atherosclerotic apolipoprotein E-deficient mice.
Journal of agricultural and food chemistry 2007;55(5):2028-33.
2006: Orit Rozenberg; Michael Aviram
S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity.
Biochemical and biophysical research communications 2006;351(2):492-8.
2006: Leonid Gaidukov; Mira Rosenblat; Michael Aviram; Dan S Tawfik
The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux.
Journal of lipid research 2006;47(11):2492-502.
2006: Maayan Shiner; Bianca Fuhrman; Michael Aviram
A biphasic U-shape effect of cellular oxidative stress on the macrophage anti-oxidant paraoxonase 2 (PON2) enzymatic activity.
Biochemical and biophysical research communications 2006;349(3):1094-9.
2006: Bianca Fuhrman; Nina Volkova; Michael Aviram
Postprandial serum triacylglycerols and oxidative stress in mice after consumption of fish oil, soy oil or olive oil: possible role for paraoxonase-1 triacylglycerol lipase-like activity.
Nutrition (Burbank, Los Angeles County, Calif.) 2006;22(9):922-30.
2006: Orit Rozenberg; Amy Howell; Michael Aviram
Pomegranate juice sugar fraction reduces macrophage oxidative state, whereas white grape juice sugar fraction increases it.
Atherosclerosis 2006;188(1):68-76.
2006: Mira Rosenblat; Tony Hayek; Michael Aviram
Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages.
Atherosclerosis 2006;187(2):363-71.
2006: Mira Rosenblat; Rachel Karry; Michael Aviram
Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes.
Atherosclerosis 2006;187(1):74-81.
2006: Mira Rosenblat; Roni Oren; Michael Aviram
Lysophosphatidylcholine (LPC) attenuates macrophage-mediated oxidation of LDL.
Biochemical and biophysical research communications 2006;344(4):1271-7.
2006: Mira Rosenblat; Leonid Gaidukov; Olga Khersonsky; Jacob Vaya; Roni Oren; Dan S Tawfik; Michael Aviram
The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux.
The Journal of biological chemistry 2006;281(11):7657-65.
2006: Mira Rosenblat; Nina Volkova; Raymond Coleman; Michael Aviram
Pomegranate byproduct administration to apolipoprotein e-deficient mice attenuates atherosclerosis development as a result of decreased macrophage oxidative stress and reduced cellular uptake of oxidized low-density lipoprotein.
Journal of agricultural and food chemistry 2006;54(5):1928-35.
2006: Michael Aviram
HDL--associated paraoxonase 1 (PON1) and dietary antioxidants attenuate lipoprotein oxidation, macrophage foam cells formation and atherosclerosis development.
Pathophysiology of haemostasis and thrombosis 2006;35(1-2):146-51.
2006: Andrea Szuchman; Michael Aviram; Khatib Soliman; Snait Tamir; Jacob Vaya
Exogenous N-linoleoyl tyrosine marker as a tool for the characterization of cellular oxidative stress in macrophages.
Free radical research 2006;40(1):41-52.
2006: Shany Blum; Michael Aviram; Ami Ben-Amotz; Yishai Levy
Effect of a Mediterranean meal on postprandial carotenoids, paraoxonase activity and C-reactive protein levels.
Annals of nutrition & metabolism 2006;50(1):20-4.
2005: Tony Hayek; Khetam Hussein; Michael Aviram; Raymond Coleman; Shlomo Keidar; Elsa Pavoltzky; Marielle Kaplan
Macrophage foam-cell formation in streptozotocin-induced diabetic mice: stimulatory effect of glucose.
Atherosclerosis 2005;183(1):25-33.
2005: Bianca Fuhrman; Nina Volkova; Michael Aviram
Pomegranate juice inhibits oxidized LDL uptake and cholesterol biosynthesis in macrophages.
The Journal of nutritional biochemistry 2005;16(9):570-6.
2005: Raanan Shamir; Corina Hartman; Rachel Karry; Elsa Pavlotzky; Rami Eliakim; Jesse Lachter; Alain Suissa; Michael Aviram
Paraoxonases (PONs) 1, 2, and 3 are expressed in human and mouse gastrointestinal tract and in Caco-2 cell line: selective secretion of PON1 and PON2.
Free radical biology & medicine 2005;39(3):336-44.
2005: Michael Aviram; Mira Rosenblat
Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences.
Current opinion in lipidology 2005;16(4):393-9.
2005: Orit Rozenberg; Diana M Shih; Michael Aviram
Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice.
Atherosclerosis 2005;181(1):9-18.
2005: Bianca Fuhrman; Nina Volkova; Michael Aviram
Paraoxonase 1 (PON1) is present in postprandial chylomicrons.
Atherosclerosis 2005;180(1):55-61.
2005: Bianca Fuhrman; Nina Volkova; Raymond Coleman; Michael Aviram
Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity.
The Journal of nutrition 2005;135(4):722-8.
2005: Mira Rosenblat; Jacob Vaya; Diana M Shih; Michael Aviram
Paraoxonase 1 (PON1) enhances HDL-mediated macrophage cholesterol efflux via the ABCA1 transporter in association with increased HDL binding to the cells: a possible role for lysophosphatidylcholine.
Atherosclerosis 2005;179(1):69-77.
2005: Michael Aviram; Marielle Kaplan; Mira Rosenblat; Bianca Fuhrman
Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development.
Handbook of experimental pharmacology 2005;(170):263-300.
2004: Maayan Shiner; Bianca Fuhrman; Michael Aviram
Paraoxonase 2 (PON2) expression is upregulated via a reduced-nicotinamide-adenine-dinucleotide-phosphate (NADPH)-oxidase-dependent mechanism during monocytes differentiation into macrophages.
Free radical biology & medicine 2004;37(12):2052-63.
2004: Michael Aviram; Mira Rosenblat
Paraoxonases 1, 2, and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development.
Free radical biology & medicine 2004;37(9):1304-16.
2004: Bianca Fuhrman; Ayelet Partoush; Michael Aviram
Acetylcholine esterase protects LDL against oxidation.
Biochemical and biophysical research communications 2004;322(3):974-8.
2004: Bianca Fuhrman; Maayan Shiner; Nina Volkova; Michael Aviram
Cell-induced copper ion-mediated low density lipoprotein oxidation increases during in vivo monocyte-to-macrophage differentiation.
Free radical biology & medicine 2004;37(2):259-71.
2004: Michael Aviram; Mira Rosenblat; Diana Gaitini; Samy Nitecki; Aaron Hoffman; Leslie Dornfeld; Nina Volkova; Dita Presser; Judith Attias; Harley Liker; Tony Hayek
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.
Clinical nutrition (Edinburgh, Scotland) 2004;23(3):423-33.
2004: Shlomo Keidar; Marielle Kaplan; Elsa Pavlotzky; Raymond Coleman; Tony Hayek; Shadi Hamoud; Michael Aviram
Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone.
Circulation 2004;109(18):2213-20.
2004: Marielle Kaplan; Michael Aviram
Red wine administration to apolipoprotein E-deficient mice reduces their macrophage-derived extracellular matrix atherogenic properties.
Biological research 2004;37(2):239-45.
2004: Tony Hayek; Shadi Hamoud; Shlomo Keidar; Elsa Pavlotzky; Raymond Coleman; Michael Aviram; Marielle Kaplan
Omapatrilat decreased macrophage oxidative status and atherosclerosis progression in atherosclerotic apolipoprotein E-deficient mice.
Journal of cardiovascular pharmacology 2004;43(1):140-7.
2004: Mira Rosenblat; Tony Hayek; Khetam Hussein; Michael Aviram
Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy.
Arteriosclerosis, thrombosis, and vascular biology 2004;24(1):175-80.
2003: Andrea Szuchman; Michael Aviram; Snait Tamir; Jacob Vaya
Cholesterol, linoleic acid or/and tyrosine yield different spectra of products when oxidized alone or in a mixture: studies in various oxidative systems.
Free radical research 2003;37(12):1277-88.
2003: Tony Hayek; Elsa Pavlotzky; Shadi Hamoud; Raymond Coleman; Shlomo Keidar; Michael Aviram; Marielle Kaplan
Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(11):2090-6.
2003: Shlomo Keidar; Tony Hayek; Marielle Kaplan; Elsa Pavlotzky; Shadi Hamoud; Raymond Coleman; Michael Aviram
Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice.
Journal of cardiovascular pharmacology 2003;41(6):955-63.
2003: Orit Rozenberg; Mira Rosenblat; Raymond Coleman; Diana M Shih; Michael Aviram
Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice.
Free radical biology & medicine 2003;34(6):774-84.
2003: Orit Rozenberg; Diana M Shih; Michael Aviram
Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(3):461-7.
2003: Mira Rosenblat; Dragomir I Draganov; Catherine E Watson; Charles L Bisgaier; Bert N La Du; Michael Aviram
Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(3):468-74.
2003: Jacob Vaya; Saeed Mahmood; Amiram Goldblum; Michael Aviram; Nina Volkova; Amin Shaalan; Ramadan Musa; Snait Tamir
Inhibition of LDL oxidation by flavonoids in relation to their structure and calculated enthalpy.
Phytochemistry 2003;62(1):89-99.
2002: Bianca Fuhrman; Lena Koren; Nina Volkova; Shlomo Keidar; Tony Hayek; Michael Aviram
Atorvastatin therapy in hypercholesterolemic patients suppresses cellular uptake of oxidized-LDL by differentiating monocytes.
Atherosclerosis 2002;164(1):179-85.
2002: Osamah Hussein; Julia Shneider; Mira Rosenblat; Michael Aviram
Valsartan therapy has additive anti-oxidative effect to that of fluvastatin therapy against low-density lipoprotein oxidation: studies in hypercholesterolemic and hypertensive patients.
Journal of cardiovascular pharmacology 2002;40(1):28-34.
2002: Mira Rosenblat; Raymond Coleman; Michael Aviram
Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice.
Atherosclerosis 2002;163(1):17-28.
2002: Ute M Kent; Michael Aviram; Mira Rosenblat; Paul Hollenberg
The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9.
Drug metabolism and disposition: the biological fate of chemicals 2002;30(6):709-15.
2002: Bianca Fuhrman; Michael Aviram
Preservation of paraoxonase activity by wine flavonoids: possible role in protection of LDL from lipid peroxidation.
Annals of the New York Academy of Sciences 2002;957():321-4.
2002: Michael Aviram; Bianca Fuhrman
Wine flavonoids protect against LDL oxidation and atherosclerosis.
Annals of the New York Academy of Sciences 2002;957():146-61.
2002: Bianca Fuhrman; Nina Volkova; Michael Aviram
Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase.
Atherosclerosis 2002;161(2):307-16.
2002: Shlomo Keidar; Ronit Heinrich; Marielle Kaplan; Michael Aviram
Oxidative stress increases the expression of the angiotensin-II receptor type 1 in mouse peritoneal macrophages.
Journal of the renin-angiotensin-aldosterone system : JRAAS 2002;3(1):24-30.
2002: Bianca Fuhrman; Nina Volkova; Marielle Kaplan; Dita Presser; Judith Attias; Tony Hayek; Michael Aviram
Antiatherosclerotic effects of licorice extract supplementation on hypercholesterolemic patients: increased resistance of LDL to atherogenic modifications, reduced plasma lipid levels, and decreased systolic blood pressure.
Nutrition (Burbank, Los Angeles County, Calif.) 2002;18(3):268-73.
2002: Tony Hayek; Marielle Kaplan; Ayelet Raz; Shlomo Keidar; Raymond Coleman; Michael Aviram
Ramipril administration to atherosclerotic mice reduces oxidized low-density lipoprotein uptake by their macrophages and blocks the progression of atherosclerosis.
Atherosclerosis 2002;161(1):65-74.
2002: Marielle Kaplan; Michael Aviram; Carlos Knopf; Shlomo Keidar
Angiotensin II reduces macrophage cholesterol efflux: a role for the AT-1 receptor but not for the ABC1 transporter.
Biochemical and biophysical research communications 2002;290(5):1529-34.
2002: Michael Aviram; Leslie Dornfeld; Marielle Kaplan; Raymond Coleman; Diana Gaitini; Samy Nitecki; A Hofman; Mira Rosenblat; Nina Volkova; Dita Presser; Judith Attias; Tony Hayek; Bianca Fuhrman
Pomegranate juice flavonoids inhibit low-density lipoprotein oxidation and cardiovascular diseases: studies in atherosclerotic mice and in humans.
Drugs under experimental and clinical research 2002;28(2-3):49-62.
2002: Mira Rosenblat; Orit Grunfeld; Tony Hayek; Michael Aviram
Serum paraoxonase activity and the extent of lipid peroxidation are not affected by increased levels of human apolipoprotein A-I: studies in transgenic mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2002;40(1):9-14.
2002: Mira Rosenblat; Michael Aviram
Oxysterol-induced activation of macrophage NADPH-oxidase enhances cell-mediated oxidation of LDL in the atherosclerotic apolipoprotein E deficient mouse: inhibitory role for vitamin E.
Atherosclerosis 2002;160(1):69-80.
2001: Shlomo Keidar; Ronit Heinrich; Marielle Kaplan; Tony Hayek; Michael Aviram
Angiotensin II administration to atherosclerotic mice increases macrophage uptake of oxidized ldl: a possible role for interleukin-6.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(9):1464-9.
2001: Michael Aviram; L Dornfeld
Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure.
Atherosclerosis 2001;158(1):195-8.
2001: Marielle Kaplan; Tony Hayek; A Raz; Raymond Coleman; Leslie Dornfeld; Jacob Vaya; Michael Aviram
Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis.
The Journal of nutrition 2001;131(8):2082-9.
2001: Bianca Fuhrman; Nina Volkova; A Suraski; Michael Aviram
White wine with red wine-like properties: increased extraction of grape skin polyphenols improves the antioxidant capacity of the derived white wine.
Journal of agricultural and food chemistry 2001;49(7):3164-8.
2001: Jacob Vaya; Michael Aviram; S Mahmood; T Hayek; E Grenadir; A Hoffman; Simcha Milo
Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteins.
Free radical research 2001;34(5):485-97.
2001: Marielle Kaplan; Michael Aviram
Retention of oxidized LDL by extracellular matrix proteoglycans leads to its uptake by macrophages: an alternative approach to study lipoproteins cellular uptake.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):386-93.
2001: B Fuhrman; Michael Aviram
Flavonoids protect LDL from oxidation and attenuate atherosclerosis.
Current opinion in lipidology 2001;12(1):41-8.
2001: Michael Aviram; Jacob Vaya
Markers for low-density lipoprotein oxidation.
Methods in enzymology 2001;335():244-56.
2000: Michael Aviram
Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases.
Free radical research 2000;33 Suppl():S85-97.
2000: Tony Hayek; Michael Aviram; Ronit Heinrich; E Sakhnini; Shlomo Keidar
Losartan inhibits cellular uptake of oxidized LDL by monocyte-macrophages from hypercholesterolemic patients.
Biochemical and biophysical research communications 2000;273(2):417-20.
2000: Michael Aviram; E Hardak; Jacob Vaya; S Mahmood; Simcha Milo; Aaron Hoffman; S Billicke; Dragomir I Draganov; Mira Rosenblat
Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities.
Circulation 2000;101(21):2510-7.
2000: Bianca Fuhrman; Mira Rosenblat; Tony Hayek; Raymond Coleman; Michael Aviram
Ginger extract consumption reduces plasma cholesterol, inhibits LDL oxidation and attenuates development of atherosclerosis in atherosclerotic, apolipoprotein E-deficient mice.
The Journal of nutrition 2000;130(5):1124-31.
2000: Michael Aviram; Leslie Dornfeld; Mira Rosenblat; Nina Volkova; Marielle Kaplan; Raymond Coleman; Tony Hayek; Dita Presser; Bianca Fuhrman
Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice.
The American journal of clinical nutrition 2000;71(5):1062-76.
2000: I Maor; Tony Hayek; Mark Hirsh; Theodore C Iancu; Michael Aviram
Macrophage-released proteoglycans enhance LDL aggregation: studies in aorta from apolipoprotein E-deficient mice.
Atherosclerosis 2000;150(1):91-101.
2000: I Maor; Marielle Kaplan; Tony Hayek; Jacob Vaya; Aaron Hoffman; Michael Aviram
Oxidized monocyte-derived macrophages in aortic atherosclerotic lesion from apolipoprotein E-deficient mice and from human carotid artery contain lipid peroxides and oxysterols.
Biochemical and biophysical research communications 2000;269(3):775-80.
2000: J L Vuletich; Yoichi Osawa; Michael Aviram
Enhanced lipid oxidation by oxidatively modified myoglobin: role of protein-bound heme.
Biochemical and biophysical research communications 2000;269(3):647-51.
2000: Marielle Kaplan; Michael Aviram
Macrophage plasma membrane chondroitin sulfate proteoglycan binds oxidized low-density lipoprotein.
Atherosclerosis 2000;149(1):5-17.
2000: Bianca Fuhrman; Nina Volkova; Mira Rosenblat; Michael Aviram
Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic.
Antioxidants & redox signaling 2000;2(3):491-506.
2000: Yishai Levy; H Zaltsberg; Ami Ben-Amotz; Yoram Kanter; Michael Aviram
Dietary supplementation of a natural isomer mixture of beta-carotene inhibits oxidation of LDL derived from patients with diabetes mellitus.
Annals of nutrition & metabolism 2000;44(2):54-60.
1999: H Zaltzberg; Yoram Kanter; Michael Aviram; Yishai Levy
Increased plasma oxidizability and decreased erythrocyte and plasma antioxidative capacity in patients with NIDDM.
The Israel Medical Association journal : IMAJ 1999;1(4):228-31.
1999: Shlomo Keidar; Judith Attias; Ronit Heinrich; Raymond Coleman; Michael Aviram
Angiotensin II atherogenicity in apolipoprotein E deficient mice is associated with increased cellular cholesterol biosynthesis.
Atherosclerosis 1999;146(2):249-57.
1999: RC Sorenson; Charles L Bisgaier; Michael Aviram; C Hsu; Scott S Billecke; Bert N La Du
Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids : apolipoprotein A-I stabilizes activity.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2214-25.
1999: L Zhu; Charles L Bisgaier; Michael Aviram; Roger S Newton
9-cis retinoic acid induces monocyte chemoattractant protein-1 secretion in human monocytic THP-1 cells.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2105-11.
1999: Michael Aviram
Does paraoxonase play a role in susceptibility to cardiovascular disease?
Molecular medicine today 1999;5(9):381-6.
1999: Marielle Kaplan; Michael Aviram
Oxidized low density lipoprotein: atherogenic and proinflammatory characteristics during macrophage foam cell formation. An inhibitory role for nutritional antioxidants and serum paraoxonase.
Clinical chemistry and laboratory medicine : CCLM / FESCC 1999;37(8):777-87.
1999: Bert N La Du; Michael Aviram; Scott S Billecke; Mohamad Navab; SL Primo-Parmo; RC Sorenson; Theodore J Standiford
On the physiological role(s) of the paraoxonases.
Chemico-biological interactions 1999;119-120():379-88.
1999: RC Sorenson; Michael Aviram; Charles L Bisgaier; Scott S Billecke; C Hsu; Bert N La Du
Properties of the retained N-terminal hydrophobic leader sequence in human serum paraoxonase/arylesterase.
Chemico-biological interactions 1999;119-120():243-9.
1999: Mira Rosenblat; PA Belinky; Jacob Vaya; R Levy; Tony Hayek; Raymond Coleman; S Merchav; Michael Aviram
Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C.
The Journal of biological chemistry 1999;274(20):13790-9.
1999: Michael Aviram; Mira Rosenblat; Scott S Billecke; J Erogul; RC Sorenson; Charles L Bisgaier; Roger S Newton; Bert N La Du
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants.
Free radical biology & medicine 1999;26(7-8):892-904.
1999: Michael Aviram; U M Kent; Paul Hollenberg
Microsomal cytochromes P450 catalyze the oxidation of low density lipoprotein.
Atherosclerosis 1999;143(2):253-60.
1999: Michael Aviram
Macrophage foam cell formation during early atherogenesis is determined by the balance between pro-oxidants and anti-oxidants in arterial cells and blood lipoproteins.
Antioxidants & redox signaling 1999;1(4):585-94.
1999: I Maor; Michael Aviram
Macrophage released proteoglycans are involved in cell-mediated aggregation of LDL.
Atherosclerosis 1999;142(1):57-66.
1998: L Zhu; B Gong; Charles L Bisgaier; Michael Aviram; Roger S Newton
Induction of PPARgamma1 expression in human THP-1 monocytic leukemia cells by 9-cis-retinoic acid is associated with cellular growth suppression.
Biochemical and biophysical research communications 1998;251(3):842-8.
1998: Michael Aviram; Scott S Billecke; RC Sorenson; Charles L Bisgaier; R Newton; Mira Rosenblat; J Erogul; C Hsu; C Dunlop; Bert N La Du
Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(10):1617-24.
1998: Hanna Mandel; R Sharf; Moshe Berant; Ronald J A Wanders; P Vreken; Michael Aviram
Plasmalogen phospholipids are involved in HDL-mediated cholesterol efflux: insights from investigations with plasmalogen-deficient cells.
Biochemical and biophysical research communications 1998;250(2):369-73.
1998: Michael Aviram; Mira Rosenblat; Charles L Bisgaier; Roger S Newton
Atorvastatin and gemfibrozil metabolites, but not the parent drugs, are potent antioxidants against lipoprotein oxidation.
Atherosclerosis 1998;138(2):271-80.
1998: PA Belinky; Michael Aviram; S Mahmood; Jacob Vaya
Structural aspects of the inhibitory effect of glabridin on LDL oxidation.
Free radical biology & medicine 1998;24(9):1419-29.
1998: Michael Aviram; Mira Rosenblat; Charles L Bisgaier; Roger S Newton; SL Primo-Parmo; Bert N La Du
Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase.
The Journal of clinical investigation 1998;101(8):1581-90.
1998: Michael Aviram; Bianca Fuhrman
Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis.
Atherosclerosis 1998;137 Suppl():S45-50.
1998: Marielle Kaplan; K J Williams; H Mandel; Michael Aviram
Role of macrophage glycosaminoglycans in the cellular catabolism of oxidized LDL by macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(4):542-53.
1998: PA Belinky; Michael Aviram; Bianca Fuhrman; Mira Rosenblat; Jacob Vaya
The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation.
Atherosclerosis 1998;137(1):49-61.
1998: Mira Rosenblat; Michael Aviram
Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: in vitro and in vivo studies.
Free radical biology & medicine 1998;24(2):305-17.
1998: Michael Aviram; Osamah Hussein; Mira Rosenblat; S Schlezinger; Tony Hayek; Shlomo Keidar
Interactions of platelets, macrophages, and lipoproteins in hypercholesterolemia: antiatherogenic effects of HMG-CoA reductase inhibitor therapy.
Journal of cardiovascular pharmacology 1998;31(1):39-45.
1997: I Maor; Tony Hayek; Raymond Coleman; Michael Aviram
Plasma LDL oxidation leads to its aggregation in the atherosclerotic apolipoprotein E-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2995-3005.
1997: Tony Hayek; Bianca Fuhrman; Jacob Vaya; Mira Rosenblat; PA Belinky; Raymond Coleman; A Elis; Michael Aviram
Reduced progression of atherosclerosis in apolipoprotein E-deficient mice following consumption of red wine, or its polyphenols quercetin or catechin, is associated with reduced susceptibility of LDL to oxidation and aggregation.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2744-52.
1997: Bianca Fuhrman; S Buch; Jacob Vaya; PA Belinky; Raymond Coleman; Tony Hayek; Michael Aviram
Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice.
The American journal of clinical nutrition 1997;66(2):267-75.
1997: Bianca Fuhrman; A Elis; Michael Aviram
Hypocholesterolemic effect of lycopene and beta-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophages.
Biochemical and biophysical research communications 1997;233(3):658-62.
1997: Osamah Hussein; Mira Rosenblat; G Refael; Michael Aviram
Dietary selenium increases cellular glutathione peroxidase activity and reduces the enhanced susceptibility to lipid peroxidation of plasma and low-density lipoprotein in kidney transplant recipients.
Transplantation 1997;63(5):679-85.
1997: Osamah Hussein; S Schlezinger; Mira Rosenblat; Shlomo Keidar; Michael Aviram
Reduced susceptibility of low density lipoprotein (LDL) to lipid peroxidation after fluvastatin therapy is associated with the hypocholesterolemic effect of the drug and its binding to the LDL.
Atherosclerosis 1997;128(1):11-8.
1997: Michael Aviram; Tony Hayek; Bianca Fuhrman
Red wine consumption inhibits LDL oxidation and aggregation in humans and in atherosclerotic mice.
BioFactors (Oxford, England) 1997;6(4):415-9.
1997: Jacob Vaya; PA Belinky; Michael Aviram
Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation.
Free radical biology & medicine 1997;23(2):302-13.
1997: Bianca Fuhrman; O Judith; Shlomo Keidar; L Ben-Yaish; M Kaplan; Michael Aviram
Increased uptake of LDL by oxidized macrophages is the result of an initial enhanced LDL receptor activity and of a further progressive oxidation of LDL.
Free radical biology & medicine 1997;23(1):34-46.
1996: Hanna Mandel; M Getsis; Mira Rosenblat; Moshe Berant; Michael Aviram
Impaired cholesterol synthesis rate in fibroblasts and reduced cellular uptake of LDLs derived from peroxisome-deficient patients cause cellular cholesterol deficiency in peroxisome-deficient fibroblasts.
Annals of the New York Academy of Sciences 1996;804():752-5.
1996: P Ljubuncic; Bianca Fuhrman; J Oiknine; Michael Aviram; Arieh Bomzon
Effect of deoxycholic acid and ursodeoxycholic acid on lipid peroxidation in cultured macrophages.
Gut 1996;39(3):475-8.
1996: Michael Aviram; Mira Rosenblat
Phospholipase A2 and phospholipase D are involved in macrophage NADPH oxidase-mediated oxidation of low density lipoprotein.
Israel journal of medical sciences 1996;32(9):749-56.
1996: Michael Aviram; Mira Rosenblat; A Etzioni; R Levy
Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein.
Metabolism: clinical and experimental 1996;45(9):1069-79.
1996: Michael Aviram
Interaction of oxidized low density lipoprotein with macrophages in atherosclerosis, and the antiatherogenicity of antioxidants.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1996;34(8):599-608.
1996: D Carter; Bianca Fuhrman; Michael Aviram
Macrophage activation with phorbol myristate acetate is associated with cellular lipid peroxidation.
Israel journal of medical sciences 1996;32(6):479-85.
1996: Yishai Levy; M Kaplan; Ami Ben-Amotz; Michael Aviram
Effect of dietary supplementation of beta-carotene on human monocyte-macrophage-mediated oxidation of low density lipoprotein.
Israel journal of medical sciences 1996;32(6):473-8.
1996: Reuven Bergman; Y Kasif; Michael Aviram; I Maor; Y Ullman; M Gdal-On; Rachel Friedman-Birnbaum
Normolipidemic xanthelasma palpebrarum: lipid composition, cholesterol metabolism in monocyte-derived macrophages, and plasma lipid peroxidation.
Acta dermato-venereologica 1996;76(2):107-10.
1996: Shlomo Keidar; J Oiknine; A Leiba; C Shapira; M Leiba; Michael Aviram
Fosinopril reduces ADP-induced platelet aggregation in hypertensive patients.
Journal of cardiovascular pharmacology 1996;27(2):183-6.
1996: Yishai Levy; I Maor; D Presser; Michael Aviram
Consumption of eggs with meals increases the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation.
Annals of nutrition & metabolism 1996;40(5):243-51.
1996: S Keidar; M Kaplan; Michael Aviram
Angiotensin II-modified LDL is taken up by macrophages via the scavenger receptor, leading to cellular cholesterol accumulation.
Arteriosclerosis, thrombosis, and vascular biology 1996;16(1):97-105.
1995: Michael Aviram; I Maor; Shlomo Keidar; Tony Hayek; J Oiknine; Yaron Bar-El; Zvi Adler; V Kertzman; Simcha Milo
Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated.
Biochemical and biophysical research communications 1995;216(2):501-13.
1995: Tony Hayek; J Oiknine; G Dankner; JG Brook; Michael Aviram
HDL apolipoprotein A-I attenuates oxidative modification of low density lipoprotein: studies in transgenic mice.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1995;33(10):721-5.
1995: I Maor; H Mandel; Michael Aviram
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-Ketocholesterol.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(9):1378-87.
1995: Q Li; Bianca Fuhrman; Michael Aviram
Low density lipoprotein-cholesteryl ester-derived linoleic acid is mainly incorporated into the phospholipid component of the macrophages.
Israel journal of medical sciences 1995;31(8):474-8.
1995: Michael Aviram
LDL-platelet interaction under oxidative stress induces macrophage foam cell formation.
Thrombosis and haemostasis 1995;74(1):560-4.
1995: Hanna Mandel; M Getsis; Mira Rosenblat; Moshe Berant; Michael Aviram
Reduced cellular cholesterol content in peroxisome-deficient fibroblasts is associated with impaired uptake of the patient's low density lipoprotein and with reduced cholesterol synthesis.
Journal of lipid research 1995;36(6):1385-91.
1995: Shlomo Keidar; M Kaplan; A Hoffman; Michael Aviram
Angiotensin II stimulates macrophage-mediated oxidation of low density lipoproteins.
Atherosclerosis 1995;115(2):201-15.
1995: Michael Aviram
Oxidative modification of low density lipoprotein and its relation to atherosclerosis.
Israel journal of medical sciences 1995;31(4):241-9.
1995: Bianca Fuhrman; Alexandra Lavy; Michael Aviram
Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation.
The American journal of clinical nutrition 1995;61(3):549-54.
1995: E Wolfovitz; Michael Aviram; JG Brook; I Tatarsky; Naomi Lanir
Protective effect of low concentrations of oxidized low-density lipoprotein on endothelial cell integrity.
Journal of cardiovascular risk 1995;2(1):57-62.
1994: Michael Aviram; Alexandra Lavy; Bianca Fuhrman
[Plasma lipid peroxidation: inhibited by drinking red wine but stimulated by white wine].
Harefuah 1994;127(12):517-20, 575-6.
1994: Tony Hayek; J Oiknine; JG Brook; Michael Aviram
Role of HDL apolipoprotein E in cellular cholesterol efflux: studies in apo E knockout transgenic mice.
Biochemical and biophysical research communications 1994;205(2):1072-8.
1994: Alexandra Lavy; G Dankner; Michael Aviram
beta-Galactosidase-modified low density lipoprotein demonstrates increased susceptibility to lipid peroxidation and enhanced uptake by macrophages.
Israel journal of medical sciences 1994;30(12):905-7.
1994: Shlomo Keidar; Michael Aviram; I Maor; J Oiknine; JG Brook
Pravastatin inhibits cellular cholesterol synthesis and increases low density lipoprotein receptor activity in macrophages: in vitro and in vivo studies.
British journal of clinical pharmacology 1994;38(6):513-9.
1994: Bianca Fuhrman; J Oiknine; Michael Aviram
Iron induces lipid peroxidation in cultured macrophages, increases their ability to oxidatively modify LDL, and affects their secretory properties.
Atherosclerosis 1994;111(1):65-78.
1994: Michael Aviram; J Oiknine
Involvement of second messengers in lipopolysaccharide stimulation of low density lipoprotein uptake by macrophages.
Israel journal of medical sciences 1994;30(7):503-6.
1994: Tony Hayek; J Oiknine; JG Brook; Michael Aviram
Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice.
Biochemical and biophysical research communications 1994;201(3):1567-74.
1994: I Maor; Michael Aviram
Oxidized low density lipoprotein leads to macrophage accumulation of unesterified cholesterol as a result of lysosomal trapping of the lipoprotein hydrolyzed cholesteryl ester.
Journal of lipid research 1994;35(5):803-19.
1994: Shlomo Keidar; M Kaplan; C Shapira; JG Brook; Michael Aviram
Low density lipoprotein isolated from patients with essential hypertension exhibits increased propensity for oxidation and enhanced uptake by macrophages: a possible role for angiotensin II.
Atherosclerosis 1994;107(1):71-84.
1994: Michael Aviram; Mira Rosenblat
Macrophage-mediated oxidation of extracellular low density lipoprotein requires an initial binding of the lipoprotein to its receptor.
Journal of lipid research 1994;35(3):385-98.
1994: E Hochgraf; Y Levy; Michael Aviram; JG Brook; Uri Cogan
Lovastatin decreases plasma and platelet cholesterol levels and normalizes elevated platelet fluidity and aggregation in hypercholesterolemic patients.
Metabolism: clinical and experimental 1994;43(1):11-7.
1994: Alexandra Lavy; Bianca Fuhrman; A Markel; G Dankner; Ami Ben-Amotz; D Presser; Michael Aviram
Effect of dietary supplementation of red or white wine on human blood chemistry, hematology and coagulation: favorable effect of red wine on plasma high-density lipoprotein.
Annals of nutrition & metabolism 1994;38(5):287-94.
1993: Reuven Bergman; Michael Aviram; A Shemer; Y Oiknine; D A Vardi; Rachel Friedman-Birnbaum
Enhanced low-density lipoprotein degradation and cholesterol synthesis in monocyte-derived macrophages of patients with adult xanthogranulomatosis.
The Journal of investigative dermatology 1993;101(6):880-2.
1993: Osamah Hussein; G J Brook; Michael Aviram
Intraperitoneal injection of platelet secretory products into mice increases macrophage uptake of oxidized low density lipoprotein.
Israel journal of medical sciences 1993;29(8):453-9.
1993: Michael Aviram; I Maor
Phospholipase D-modified low density lipoprotein is taken up by macrophages at increased rate. A possible role for phosphatidic acid.
The Journal of clinical investigation 1993;91(5):1942-52.
1993: Alexandra Lavy; Ami Ben-Amotz; Michael Aviram
Preferential inhibition of LDL oxidation by the all-trans isomer of beta-carotene in comparison with 9-cis beta-carotene.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993;31(2):83-90.
1993: Michael Aviram
Modified forms of low density lipoprotein and atherosclerosis.
Atherosclerosis 1993;98(1):1-9.
1993: Michael Aviram; K Eias
Dietary olive oil reduces low-density lipoprotein uptake by macrophages and decreases the susceptibility of the lipoprotein to undergo lipid peroxidation.
Annals of nutrition & metabolism 1993;37(2):75-84.
1993: Alexandra Lavy; Ami Ben-Amotz; Michael Aviram
Increased susceptibility to undergo lipid peroxidation of chylomicrons and low-density lipoprotein in celiac disease.
Annals of nutrition & metabolism 1993;37(2):68-74.
1993: Michael Aviram; E Kassem
[Olive oil dietary supplementation decreases susceptibility of LDL to oxidation and its uptake by macrophages].
Harefuah 1993;124(1):1-4, 64.
1993: S Keidar; A Gilhar; M Kaplan; JG Brook; Michael Aviram
Enhanced degradation of high density lipoprotein by peritoneal macrophages from nude mice is attenuated by interleukin-1.
Artery 1993;20(5):268-79.
1992: Y Levy; R Leibowitz; Michael Aviram; JG Brook; Uri Cogan
Reduction of plasma cholesterol by lovastatin normalizes erythrocyte membrane fluidity in patients with severe hypercholesterolaemia.
British journal of clinical pharmacology 1992;34(5):427-30.
1992: Y Levy; L Klein; Michael Aviram; G J Brook; Uri Cogan
Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia.
Scandinavian journal of clinical and laboratory investigation 1992;52(7):671-7.
1992: Shlomo Keidar; M Kaplan; Mira Rosenblat; G J Brook; Michael Aviram
Apolipoprotein E and lipoprotein lipase reduce macrophage degradation of oxidized very-low-density lipoprotein (VLDL), but increase cellular degradation of native VLDL.
Metabolism: clinical and experimental 1992;41(11):1185-92.
1992: Bianca Fuhrman; G J Brook; Michael Aviram
Proteins derived from platelet alpha granules modulate the uptake of oxidized low density lipoprotein by macrophages.
Biochimica et biophysica acta 1992;1127(1):15-21.
1992: Ze'ev Hochberg; P Hertz; Gila Maor; J Oiknine; Michael Aviram
Growth hormone and insulin-like growth factor-I increase macrophage uptake and degradation of low density lipoprotein.
Endocrinology 1992;131(1):430-5.
1992: J Oiknine; Michael Aviram
Increased susceptibility to activation and increased uptake of low density lipoprotein by cholesterol-loaded macrophages.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(6):745-53.
1992: Michael Aviram; I Maor
Phospholipase A2-modified LDL is taken up at enhanced rate by macrophages.
Biochemical and biophysical research communications 1992;185(1):465-72.
1992: Shlomo Keidar; C Shapira; M Kaplan; G J Brook; Michael Aviram
[Increased propensity to oxidation of LDL of hypertensives].
Harefuah 1992;122(7):415-6, 480.
1992: Shlomo Keidar; G J Brook; Mira Rosenblat; Bianca Fuhrman; G Dankner; Michael Aviram
Involvement of the macrophage low density lipoprotein receptor-binding domains in the uptake of oxidized low density lipoprotein.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1992;12(4):484-93.
1992: R Hoffman; G J Brook; Michael Aviram
Hypolipidemic drugs reduce lipoprotein susceptibility to undergo lipid peroxidation: in vitro and ex vivo studies.
Atherosclerosis 1992;93(1-2):105-13.
1992: Michael Aviram; G Dankner; Uri Cogan; E Hochgraf; JG Brook
Lovastatin inhibits low-density lipoprotein oxidation and alters its fluidity and uptake by macrophages: in vitro and in vivo studies.
Metabolism: clinical and experimental 1992;41(3):229-35.
1992: Michael Aviram; Bianca Fuhrman; I Maor; G J Brook
Serotonin increases macrophage uptake of oxidized low density lipoprotein.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1992;30(2):55-61.
1992: Michael Aviram
Low density lipoprotein modification by cholesterol oxidase induces enhanced uptake and cholesterol accumulation in cells.
The Journal of biological chemistry 1992;267(1):218-25.
1992: Y Levy; E Hochgraf; Michael Aviram; JG Brook; U Cogan
A Sex-dependent Effect of Aspirin on Platelet Membrane Fluidity.
Platelets 1992;3(1):57-9.
1992: Hanna Mandel; Moshe Berant; D Meiron; A Aizin; J Oiknine; JG Brook; Michael Aviram
Plasma lipoproteins and monocyte-macrophages in a peroxisome-deficient system: study of a patient with infantile refsum disease.
Journal of inherited metabolic disease 1992;15(5):774-84.
1991: Michael Aviram; Shlomo Keidar; G J Brook
Dual effect of lovastatin and simvastatin on LDL-macrophage interaction.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1991;29(10):657-64.
1991: Michael Aviram
The contribution of the macrophage receptor for oxidized LDL to its cellular uptake.
Biochemical and biophysical research communications 1991;179(1):359-65.
1991: Alexandra Lavy; G J Brook; G Dankner; Ami Ben-Amotz; Michael Aviram
Enhanced in vitro oxidation of plasma lipoproteins derived from hypercholesterolemic patients.
Metabolism: clinical and experimental 1991;40(8):794-9.
1991: Bianca Fuhrman; G J Brook; Michael Aviram
Lipid-protein particles secreted from activated platelets reduce macrophage uptake of low density lipoprotein.
Atherosclerosis 1991;89(2-3):163-73.
1991: Bianca Fuhrman; G J Brook; Michael Aviram
Activated platelets secrete a protein-like factor that stimulates oxidized-LDL receptor activity in macrophages.
Journal of lipid research 1991;32(7):1113-23.
1991: Michael Aviram; Shlomo Keidar; Mira Rosenblat; G J Brook
Reduced uptake of cholesterol esterase-modified low density lipoprotein by macrophages.
The Journal of biological chemistry 1991;266(18):11567-74.
1991: I Maor; G J Brook; Michael Aviram
Platelet secreted lipoprotein-like particle is taken up by the macrophage scavenger receptor and enhances cellular cholesterol accumulation.
Atherosclerosis 1991;88(2-3):163-74.
1991: Michael Aviram; Uri Cogan; Shoshana Mokady
Excessive dietary tryptophan enhances plasma lipid peroxidation in rats.
Atherosclerosis 1991;88(1):29-34.
1991: Michael Aviram; Mira Rosenblat; JG Brook
Secretory products from human monocyte-derived macrophages enhance platelet aggregation.
Metabolism: clinical and experimental 1991;40(3):270-4.
1991: Michael Aviram; G Davidai; G J Brook
[Platelet hypoactivity in hypocholesterolemia].
Harefuah 1991;120(4):177-9.
1991: Michael Aviram; D Presser
Oxidized low-density lipoprotein reduces plasma coagulation in vitro.
Scandinavian journal of clinical and laboratory investigation 1991;51(1):17-21.
1991: L Klein; Michael Aviram; G J Brook; Shoshana Mokady; Uri Cogan
Decreased very low density lipoprotein fluidity in familial hypercholesterolemia.
Israel journal of medical sciences 1991;27(2):70-4.
1991: Reuven Bergman; Michael Aviram; O Bitterman-Deutsch; Y Oiknine; A Shemer; A Srebnik; JG Brook; Rachel Friedman-Birnbaum
Neutral lipid storage disease with ichthyosis: serum apolipoprotein levels and cholesterol metabolism in monocyte-derived macrophages.
Journal of inherited metabolic disease 1991;14(2):241-6.
1990: Michael Aviram
Malondialdehyde affects the physico-chemical and biological characteristics of oxidized low density lipoprotein.
Atherosclerosis 1990;84(2-3):141-3.
1990: Michael Aviram; D Presser
Platelet secretory substances enhance in vitro plasma coagulation.
Israel journal of medical sciences 1990;26(10):585-7.
1990: Shoshana Mokady; Uri Cogan; Michael Aviram
Dietary tryptophan enhances platelet aggregation in rats.
Journal of nutritional science and vitaminology 1990;36 Suppl 2():S177-80.
1990: Reuven Bergman; Rachel Friedman-Birnbaum; Michael Aviram; I Katz; H Kerner; JG Brook
Adult xanthogranulomatosis associated with abnormal plasma apolipoprotein levels.
Clinical and experimental dermatology 1990;15(5):372-5.
1990: Michael Aviram; G Dankner; JG Brook
Platelet secretory products increase low density lipoprotein oxidation, enhance its uptake by macrophages, and reduce its fluidity.
Arteriosclerosis (Dallas, Tex.) 1990;10(4):559-63.
1990: Tony Hayek; Bianca Fuhrman; Yishai Levy; Michael Aviram; JG Brook
Intralipid infusion in patients with familial hypercholesterolemia. Effect of serum and plasma lipoproteins on platelet aggregation and on macrophage cholesterol metabolism.
Atherosclerosis 1990;81(1):61-9.
1989: Tony Hayek; Bianca Fuhrman; Yishai Levy; Michael Aviram; JG Brook
[Intralipid infusion in familial hypercholesterolemia].
Harefuah 1989;117(5-6):122-6.
1989: Bianca Fuhrman; I Maor; Mira Rosenblat; G Dankner; Michael Aviram; JG Brook
Modification of LDL by platelet secretory products induces enhanced uptake and cholesterol accumulation in macrophages.
Biochemical medicine and metabolic biology 1989;42(1):9-20.
1989: G J Brook; Shlomo Keidar; M Boulos; E Grenadier; A Wiener; N Shehada; W Markiewicz; A Benderli; Michael Aviram
Familial homozygous hypercholesterolemia: clinical and cardiovascular features in 18 patients.
Clinical cardiology 1989;12(6):333-8.
1989: Michael Aviram
Platelet secretory products enhance LDL receptor activity and inhibit scavenger receptor activity in human monocyte derived macrophages.
Metabolism: clinical and experimental 1989;38(5):425-30.
1989: Michael Aviram; R J Deckelbaum
Intralipid infusion into humans reduces in vitro platelet aggregation and alters platelet lipid composition.
Metabolism: clinical and experimental 1989;38(4):343-7.
1989: S Keidar; Michael Aviram; E Grenadier; W Markiewicz; JG Brook
Low-density lipoprotein derived from atherosclerotic patients enhances macrophage cholesterol accumulation and in vitro platelet aggregation.
Biochemical medicine and metabolic biology 1989;41(2):117-24.
1989: Michael Aviram
Modified forms of low density lipoprotein affect platelet aggregation in vitro.
Thrombosis research 1989;53(6):561-7.
1989: Michael Aviram; Shoshana Mokady; Uri Cogan
An effective method for plasma lipoprotein separation: studies of various animal species.
Comparative biochemistry and physiology. B, Comparative biochemistry 1989;93(2):279-82.
1989: Michael Aviram; Bianca Fuhrman; Shlomo Keidar; I Maor; Mira Rosenblat; G Dankner; G Brook
Platelet-modified low density lipoprotein induces macrophage cholesterol accumulation and platelet activation.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1989;27(1):3-12.
1989: S Keidar; Michael Aviram; E Grenadier; W Markiewicz; JG Brook
Arterial blood derived low density lipoprotein increases platelet aggregation and macrophage cholesterol content in comparison to lipoprotein derived from veinous blood.
Artery 1989;16(2):62-71.
1988: Michael Aviram
The effect of platelets on macrophage lipoprotein metabolism.
Atherosclerosis 1988;73(2-3):269-71.
1988: Michael Aviram; I Maor; Mira Rosenblat; G Dankner; JG Brook
Platelet-modified lipoprotein induced by thrombin: effect of whole blood and plasma.
Israel journal of medical sciences 1988;24(4-5):193-200.
1987: Michael Aviram; A Viener; JG Brook
Reduced plasma high-density lipoprotein and increased platelet activity in arterial versus venous blood.
Postgraduate medical journal 1987;63(736):91-4.
1986: Michael Aviram; Mira Rosenblat; M Potesman; G Dankner; JG Brook
Plasma lipoprotein and platelet function after heparin injection: studies in normal fasted and postprandial and in type V hyperlipoproteinemic subjects.
Biochemical medicine and metabolic biology 1986;35(3):279-92.
1986: A Viener; Michael Aviram; JG Brook
[The atherogenic aspect of the lipoprotein composition in hemodialysis patients].
Harefuah 1986;110(5):217-9.
1984: A Viener; JG Brook; Michael Aviram
Abnormal plasma lipoprotein composition in hypercholesterolaemic patients induces platelet activation.
European journal of clinical investigation 1984;14(3):207-13.
1982: JG Brook; Michael Aviram; A Viener; E Shilansky; W Markiewicz
High-density lipoprotein subfractions in normolipidemic patients with coronary atherosclerosis.
Circulation 1982;66(5):923-6.