Kaikobad Irani

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Lee Hwan Myung; Jeon Byeong Hwa; Won Kyung-Jong; Lee Chang-Kwon; Park Tae-Kyu; Choi Wahn Soo; Bae Young Min; Kim Hyo Shin; Lee Sang Ki; Park Seung Hwa; Irani Kaikobad; Kim Bokyung
Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway.
Kim Cuk-Seong; Jung Saet-Byel; Naqvi Asma; Hoffman Timothy A; DeRicco Jeremy; Yamamori Tohru; Cole Marsha P; Jeon Byeong-Hwa; Irani Kaikobad
p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.
Haga Sanae; Terui Keita; Fukai Moto; Oikawa Yuko; Irani Kaikobad; Furukawa Hiroyuki; Todo Satoru; Ozaki Michitaka
Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins.

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2009: Lee Hwan Myung; Jeon Byeong Hwa; Won Kyung-Jong; Lee Chang-Kwon; Park Tae-Kyu; Choi Wahn Soo; Bae Young Min; Kim Hyo Shin; Lee Sang Ki; Park Seung Hwa; Irani Kaikobad; Kim Bokyung
Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway.
Circulation research 2009;104(2):219-27, 5p following 227.
2008: Kim Cuk-Seong; Jung Saet-Byel; Naqvi Asma; Hoffman Timothy A; DeRicco Jeremy; Yamamori Tohru; Cole Marsha P; Jeon Byeong-Hwa; Irani Kaikobad
p53 impairs endothelium-dependent vasomotor function through transcriptional upregulation of p66shc.
Circulation research 2008;103(12):1441-50.
2008: Haga Sanae; Terui Keita; Fukai Moto; Oikawa Yuko; Irani Kaikobad; Furukawa Hiroyuki; Todo Satoru; Ozaki Michitaka
Preventing hypoxia/reoxygenation damage to hepatocytes by p66(shc) ablation: up-regulation of anti-oxidant and anti-apoptotic proteins.
Journal of hepatology 2008;48(3):422-32.
2007: Yang Xiao Ping; Mattagajasingh Subhendra; Su Shaobo; Chen Guibin; Cai Zheqing; Fox-Talbot Karen; Irani Kaikobad; Becker Lewis C
Fractalkine upregulates intercellular adhesion molecule-1 in endothelial cells through CX3CR1 and the Jak Stat5 pathway.
Circulation research 2007;101(10):1001-8.
2007: Mattagajasingh Ilwola; Kim Cuk-Seong; Naqvi Asma; Yamamori Tohru; Hoffman Timothy A; Jung Saet-Byel; DeRicco Jeremy; Kasuno Kenji; Irani Kaikobad
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(37):14855-60.
2007: Santhanam Lakshmi; Lim Hyun Kyo; Lim Hyun Kyoung; Miriel Victor; Brown Tashalee; Patel Meet; Balanson Sarit; Ryoo Sungwoo; Anderson Mirinda; Irani Kaikobad; Khanday Firdous; Di Costanzo Luigi; Nyhan Daniel; Hare Joshua M; Christianson David W; Rivers Richard; Shoukas Artin; Berkowitz Dan E
Inducible NO synthase dependent S-nitrosylation and activation of arginase1 contribute to age-related endothelial dysfunction.
Circulation research 2007;101(7):692-702.
2007: Kasuno K; Naqvi A; Dericco J; Yamamori T; Santhanam L; Mattagajasingh I; Yang S; Meyskens F L; Bosserhoff A-K; Irani K
Antagonism of p66shc by melanoma inhibitory activity.
Cell death and differentiation 2007;14(8):1414-21.
2007: Irani Kaikobad
G protein-coupled receptor G2A: friend or foe of the vasculature?
Circulation research 2007;100(4):450-1.
2006: Ferlito Marcella; Irani Kaikobad; Faraday Nauder; Lowenstein Charles J
Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(31):11689-94.
2006: Khanday Firdous A; Santhanam Lakshmi; Kasuno Kenji; Yamamori Tohru; Naqvi Asma; Dericco Jeremy; Bugayenko Artem; Mattagajasingh Ilwola; Disanza Andrea; Scita Giorgio; Irani Kaikobad
Sos-mediated activation of rac1 by p66shc.
The Journal of cell biology 2006;172(6):817-22.
2006: Kim Cuk Seong; Son Sook Jin; Kim Eun Kyung; Kim Seon Nyo; Yoo Dae Goon; Kim Hyo Shin; Ryoo Sung Woo; Lee Sang Do; Irani Kaikobad; Jeon Byeong Hwa
Apurinic/apyrimidinic endonuclease1/redox factor-1 inhibits monocyte adhesion in endothelial cells.
Cardiovascular research 2006;69(2):520-6.
2006: Khanday Firdous A; Yamamori Tohru; Mattagajasingh Ilwola; Zhang Zhe; Bugayenko Artem; Naqvi Asma; Santhanam Lakshmi; Nabi Nusrat; Kasuno Kenji; Day Billy W; Irani Kaikobad
Rac1 leads to phosphorylation-dependent increase in stability of the p66shc adaptor protein: role in Rac1-induced oxidative stress.
Molecular biology of the cell 2006;17(1):122-9.
2005: Yang Sun; Irani Kaikobad; Heffron Susan E; Jurnak Frances; Meyskens Frank L
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor.
Molecular cancer therapeutics 2005;4(12):1923-35.
2005: Yamamori Tohru; White Anthony R; Mattagajasingh Ilwola; Khanday Firdous A; Haile Azeb; Qi Bing; Jeon Byeong Hwa; Bugayenko Artem; Kasuno Kenji; Berkowitz Dan E; Irani Kaikobad
P66shc regulates endothelial NO production and endothelium-dependent vasorelaxation: implications for age-associated vascular dysfunction.
Journal of molecular and cellular cardiology 2005;39(6):992-5.
2005: Harfouche Rania; Malak Nelly Abdel; Brandes Ralf P; Karsan Aly; Irani Kaikobad; Hussain Sabah N A
Roles of reactive oxygen species in angiopoietin-1/tie-2 receptor signaling.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(12):1728-30.
2005: Li Manxiang; Chiou Kuan-Rau; Bugayenko Artem; Irani Kaikobad; Kass David A
Reduced wall compliance suppresses Akt-dependent apoptosis protection stimulated by pulse perfusion.
Circulation research 2005;97(6):587-95.
2005: Matsushita Kenji; Morrell Craig N; Mason Rebecca J A; Yamakuchi Munekazu; Khanday Firdous A; Irani Kaikobad; Lowenstein Charles J
Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor.
The Journal of cell biology 2005;170(1):73-9.
2005: Yang Xiao Ping; Irani Kaikobad; Mattagajasingh Subhendra; Dipaula Anthony; Khanday Firdous; Ozaki Michitaka; Fox-Talbot Karen; Baldwin William M; Becker Lewis C
Signal transducer and activator of transcription 3alpha and specificity protein 1 interact to upregulate intercellular adhesion molecule-1 in ischemic-reperfused myocardium and vascular endothelium.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(7):1395-400.
2005: Matsushita Kenji; Yamakuchi Munekazu; Morrell Craig N; Ozaki Michitaka; O'Rourke Brian; Irani Kaikobad; Lowenstein Charles J
Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis.
Blood 2005;105(1):207-14.
2004: Terui Keita; Enosawa Shin; Haga Sanae; Zhang Hui Qi; Kuroda Hiroaki; Kouchi Katsunori; Matsunaga Tadashi; Yoshida Hideo; Engelhardt John F; Irani Kaikobad; Ohnuma Naomi; Ozaki Michitaka
Stat3 confers resistance against hypoxia/reoxygenation-induced oxidative injury in hepatocytes through upregulation of Mn-SOD.
Journal of hepatology 2004;41(6):957-65.
2004: Jeon Byeong Hwa; Gupta Gaurav; Park Young Chul; Qi Bing; Haile Azeb; Khanday Firdous A; Liu Yan-Xia; Kim Jin-Man; Ozaki Michitaka; White Anthony R; Berkowitz Dan E; Irani Kaikobad
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.
Circulation research 2004;95(9):902-10.
2004: Yang Shui-xiang; Yan Juan; Deshpande Shailesh S; Irani Kaikobad; Lowenstein Charles J
Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells.
Chinese medical journal 2004;117(8):1143-50.
2004: Guo Lei; Haga Sanae; Enosawa Shin; Naruse Katsutoshi; Harihara Yasushi; Sugawara Yasuhiko; Irani Kaikobad; Makuuchi Masatoshi; Ozaki Michitaka
Improved hepatic regeneration with reduced injury by redox factor-1 in a rat small-sized liver transplant model.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(6):879-87.
2004: Ozaki Michitaka; Irani Kaikobad
Measurement of in vivo oxidative stress regulated by the Rac1 GTPase.
Methods in enzymology 2004;381():184-91.
2003: Haga Sanae; Terui Keita; Zhang Hui Qi; Enosawa Shin; Ogawa Wataru; Inoue Hiroshi; Okuyama Torayuki; Takeda Kiyoshi; Akira Shizuo; Ogino Tetsuya; Irani Kaikobad; Ozaki Michitaka
Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms.
The Journal of clinical investigation 2003;112(7):989-98.
2003: Ozaki M; Haga S; Zhang H Q; Irani K; Suzuki S
Inhibition of hypoxia/reoxygenation-induced oxidative stress in HGF-stimulated antiapoptotic signaling: role of PI3-K and Akt kinase upon rac1.
Cell death and differentiation 2003;10(5):508-15.
2003: Jeon Byeong Hwa; Khanday Firdous; Deshpande Shailesh; Haile Azeb; Ozaki Michitaka; Irani Kaikobad
Tie-ing the antiinflammatory effect of angiopoietin-1 to inhibition of NF-kappaB.
Circulation research 2003;92(6):586-8.
2003: Peng Xinqi; Haldar Saptarsi; Deshpande Shailesh; Irani Kaikobad; Kass David A
Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium.
Hypertension 2003;41(2):378-81.
2003: Deshpande Shailesh S; Qi Bing; Park Young Chul; Irani Kaikobad
Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence.
Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):e1-6.
2002: Wang Lixin; Cummings Rhett; Usatyuk Peter; Morris Andrew; Irani Kaikobad; Natarajan Viswanathan
Involvement of phospholipases D1 and D2 in sphingosine 1-phosphate-induced ERK (extracellular-signal-regulated kinase) activation and interleukin-8 secretion in human bronchial epithelial cells.
The Biochemical journal 2002;367(Pt 3):751-60.
2002: Hu Qinghua; Yu Zu-Xi; Ferrans Victor J; Takeda Kazuyo; Irani Kaikobad; Ziegelstein Roy C
Critical role of NADPH oxidase-derived reactive oxygen species in generating Ca2+ oscillations in human aortic endothelial cells stimulated by histamine.
The Journal of biological chemistry 2002;277(36):32546-51.
2002: Angkeow P; Deshpande S S; Qi B; Liu Y-X; Park Y C; Jeon B H; Ozaki M; Irani K
Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis.
Cell death and differentiation 2002;9(7):717-25.
2002: Ng C K Domingos; Deshpande Shailesh S; Irani Kaikobad; Alevriadou B Rita
Adhesion of flowing monocytes to hypoxia-reoxygenation-exposed endothelial cells: role of Rac1, ROS, and VCAM-1.
American journal of physiology. Cell physiology 2002;283(1):C93-102.
2002: Ozaki Michitaka; Suzuki Seiichi; Irani Kaikobad
Redox factor-1/APE suppresses oxidative stress by inhibiting the rac1 GTPase.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(8):889-90.
2002: Deshpande S S; Irani K
Oxidant signalling in carcinogenesis: a commentary.
Human & experimental toxicology 2002;21(2):63-4.
2001: Abid M R; Tsai J C; Spokes K C; Deshpande S S; Irani K; Aird W C
Vascular endothelial growth factor induces manganese-superoxide dismutase expression in endothelial cells by a Rac1-regulated NADPH oxidase-dependent mechanism.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(13):2548-50.
2001: Ozaki M; Deshpande S; Angkeow P; Bellan J; Lowenstein C J; Dinauer M C; Goldschmidt-Clermont P; Suzuki S; Irani K
Targeted inhibition of the small GTPase protects against ischemia/reperfusion liver injury in mice.
Transplantation proceedings 2001;33(1-2):863-4.
2000: Ozaki M; Deshpande S S; Angkeow P; Suzuki S; Irani K
Rac1 regulates stress-induced, redox-dependent heat shock factor activation.
The Journal of biological chemistry 2000;275(45):35377-83.
2000: Deshpande S S; Angkeow P; Huang J; Ozaki M; Irani K
Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(12):1705-14.
2000: Irani K
Oxidant signaling in vascular cell growth, death, and survival : a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling.
Circulation research 2000;87(3):179-83.
2000: Hu Q; Zheng G; Zweier J L; Deshpande S; Irani K; Ziegelstein R C
NADPH oxidase activation increases the sensitivity of intracellular Ca2+ stores to inositol 1,4,5-trisphosphate in human endothelial cells.
The Journal of biological chemistry 2000;275(21):15749-57.
2000: Ozaki M; Deshpande S S; Angkeow P; Bellan J; Lowenstein C J; Dinauer M C; Goldschmidt-Clermont P J; Irani K
Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(2):418-29.
1999: Hu Q; Deshpande S; Irani K; Ziegelstein R C
[Ca(2+)](i) oscillation frequency regulates agonist-stimulated NF-kappaB transcriptional activity.
The Journal of biological chemistry 1999;274(48):33995-8.
1999: Yeh L H; Park Y J; Hansalia R J; Ahmed I S; Deshpande S S; Goldschmidt-Clermont P J; Irani K; Alevriadou B R
Shear-induced tyrosine phosphorylation in endothelial cells requires Rac1-dependent production of ROS.
The American journal of physiology 1999;276(4 Pt 1):C838-47.
1998: Irani K; Pham Y; Coleman L D; Roos C; Cooke G E; Miodovnik A; Karim N; Wilhide C C; Bray P F; Goldschmidt-Clermont P J
Priming of platelet alphaIIbbeta3 by oxidants is associated with tyrosine phosphorylation of beta3.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(11):1698-706.
1998: Tanaka K; Pracyk J B; Takeda K; Yu Z X; Ferrans V J; Deshpande S S; Ozaki M; Hwang P M; Lowenstein C J; Irani K; Finkel T
Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism.
The Journal of biological chemistry 1998;273(40):25922-8.
1998: Pracyk J B; Tanaka K; Hegland D D; Kim K S; Sethi R; Rovira I I; Blazina D R; Lee L; Bruder J T; Kovesdi I; Goldshmidt-Clermont P J; Irani K; Finkel T
A requirement for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy.
The Journal of clinical investigation 1998;102(5):929-37.
1998: Doanes A M; Irani K; Goldschmidt-Clermont P J; Finkel T
A requirement for rac1 in the PDGF-stimulated migration of fibroblasts and vascular smooth cells.
Biochemistry and molecular biology international 1998;45(2):279-87.
1998: Irani K; Goldschmidt-Clermont P J
Ras, superoxide and signal transduction.
Biochemical pharmacology 1998;55(9):1339-46.
1998: Kim K S; Takeda K; Sethi R; Pracyk J B; Tanaka K; Zhou Y F; Yu Z X; Ferrans V J; Bruder J T; Kovesdi I; Irani K; Goldschmidt-Clermont P; Finkel T
Protection from reoxygenation injury by inhibition of rac1.
The Journal of clinical investigation 1998;101(9):1821-6.
1997: Moore K A; Sethi R; Doanes A M; Johnson T M; Pracyk J B; Kirby M; Irani K; Goldschmidt-Clermont P J; Finkel T
Rac1 is required for cell proliferation and G2/M progression.
The Biochemical journal 1997;326 ( Pt 1)():17-20.
1997: Irani K; Xia Y; Zweier J L; Sollott S J; Der C J; Fearon E R; Sundaresan M; Finkel T; Goldschmidt-Clermont P J
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts.
Science (New York, N.Y.) 1997;275(5306):1649-52.
1996: Sulciner D J; Irani K; Yu Z X; Ferrans V J; Goldschmidt-Clermont P; Finkel T
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation.
Molecular and cellular biology 1996;16(12):7115-21.
1996: Crawford L E; Milliken E E; Irani K; Zweier J L; Becker L C; Johnson T M; Eissa N T; Crystal R G; Finkel T; Goldschmidt-Clermont P J
Superoxide-mediated actin response in post-hypoxic endothelial cells.
The Journal of biological chemistry 1996;271(43):26863-7.
1996: Sundaresan M; Yu Z X; Ferrans V J; Sulciner D J; Gutkind J S; Irani K; Goldschmidt-Clermont P J; Finkel T
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
The Biochemical journal 1996;318 ( Pt 2)():379-82.
1995: Sundaresan M; Yu Z X; Ferrans V J; Irani K; Finkel T
Requirement for generation of H2O2 for platelet-derived growth factor signal transduction.
Science (New York, N.Y.) 1995;270(5234):296-9.
1994: Irani K; Herzlinger S; Finkel T
Ras proteins regulate multiple mitogenic pathways in A10 vascular smooth muscle cells.
Biochemical and biophysical research communications 1994;202(3):1252-8.

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Kaikobad Irani

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