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Tetsumi Irie

Research Profile

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yuki kondo; Toru Maruyama; Yohei Miyamoto; Keizo Sato; Yusuke Fukumoto; Naotaka Hamasaki; Sumio Hirata; Mitsuru Irikura; Yoichi Ishitsuka; Daisuke Kadowaki; Tetsumi Irie
Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation.
Yoshiro Tomishima; Hirokazu Furusho; Mitsuru Irikura; Yoichi Ishitsuka; Naoya Matsunaga; Minako Nagatome; Shigehiro Ohdo; Tetsumi Irie
Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
Tomoko Somekawa-Kondo; Kazuo Takahama; Kaori Tanaka; Keitaro Yamaguchi; Toshio Yamazaki; Mitsuru Irikura; Yoichi Ishitsuka; Sachiko Ito; Hiroshi Moriuchi; Yukio Ando; Tetsumi Irie
Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.

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All Publications

2013: yuki kondo; Toru Maruyama; Yohei Miyamoto; Keizo Sato; Yusuke Fukumoto; Naotaka Hamasaki; Sumio Hirata; Mitsuru Irikura; Yoichi Ishitsuka; Daisuke Kadowaki; Tetsumi Irie
Phosphoenolpyruvate, a glycolytic intermediate, as a cytoprotectant and antioxidant in ex-vivo cold-preserved mouse liver: a potential application for organ preservation.
The Journal of pharmacy and pharmacology 2013;65(3):390-401.
2013: Yoshiro Tomishima; Hirokazu Furusho; Mitsuru Irikura; Yoichi Ishitsuka; Naoya Matsunaga; Minako Nagatome; Shigehiro Ohdo; Tetsumi Irie
Ozagrel hydrochloride, a selective thromboxane A₂ synthase inhibitor, alleviates liver injury induced by acetaminophen overdose in mice.
BMC gastroenterology 2013;13():21.
2013: Tomoko Somekawa-Kondo; Kazuo Takahama; Kaori Tanaka; Keitaro Yamaguchi; Toshio Yamazaki; Mitsuru Irikura; Yoichi Ishitsuka; Sachiko Ito; Hiroshi Moriuchi; Yukio Ando; Tetsumi Irie
Aminophylline, administered at usual doses for rodents in pharmacological studies, induces hippocampal neuronal cell injury under low tidal volume hypoxic conditions in guinea-pigs.
The Journal of pharmacy and pharmacology 2013;65(1):102-14.
2012: Daisuke Kadowaki; Kenichiro Kitamura; Toru Maruyama; Yuki Narita; Masaki Otagiri; Satomi Sumikawa; Kazuaki Taguchi; Kanami Arimizu; Victor Tuan Giam Chuang; Tetsumi Irie; Yoichi Ishitsuka; Sumio Hirata
Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats.
Life sciences 2012;91(25-26):1304-8.
2012: Mitsuru Irikura; Yoichi Ishitsuka; Akihiko Kawase; Yuichi Kondo; Eri Minami; Tetsumi Irie
Abnormal Movements of Japanese Infants following Treatment with Midazolam in a Neonatal Intensive Care Unit: Incidence and Risk Factors.
ISRN pharmacology 2012;2012():950603.
2012: yuki kondo; Masataka Kuroda; Toru Maruyama; Minako Nagatome; Keizo Sato; Yuta Tanaka; Naotaka Hamasaki; Sumio Hirata; Mitsuru Irikura; Yoichi Ishitsuka; Daisuke Kadowaki; Tetsumi Irie
Phosphoenolpyruvic acid, an intermediary metabolite of glycolysis, as a potential cytoprotectant and anti-oxidant in HeLa cells.
Biological & pharmaceutical bulletin 2012;35(4):606-11.
2012: Tetsumi Irie; Atsumi Nitta; Akinori Akaike
[Current state of training in pharmacy education using a problem-based learning/tutorial model with simulated patients and standardized patients at National University Corporation].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(3):357-63.
2010: Chang-qing Yang; Peng-yuan Sun; Da-zhi Ding; Hiroshi Moriuchi; Yoichi Ishitsuka; Mitsuru Irikura; Tetsumi Irie
The ethical Kampo formulation Sho-seiryu-to (TJ-19) prevents bleomycin-induced pulmonary fibrosis in rats.
Biological & pharmaceutical bulletin 2010;33(8):1438-42.
2009: Yoichi Ishitsuka; Hiroshi Moriuchi; Yoichiro Isohama; Hidehiro Tokunaga; Keita Hatamoto; Sumika Kurita; Mitsuru Irikura; Ken-Ichi Iyama; Tetsumi Irie
A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs.
Journal of pharmacological sciences 2009;111(2):211-5.
2009: Chang-Qing Yang; Yoichi Ishitsuka; Hiroshi Moriuchi; Saeid Golbidi; Zhen-Ji Jin; Mitsuru Irikura; Tetsumi Irie
Protection afforded by a herbal medicine, Sho-seiryu-to (TJ-19), against oleic acid-induced acute lung injury in guinea-pigs.
The Journal of pharmacy and pharmacology 2009;61(7):925-32.
2009: Keiichi Motoyama; Hiroshi Toyodome; Risako Onodera; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama; Hidetoshi Arima
Involvement of lipid rafts of rabbit red blood cells in morphological changes induced by methylated beta-cyclodextrins.
Biological & pharmaceutical bulletin 2009;32(4):700-5.
2009: Yoichi Ishitsuka; Hiroshi Moriuchi; Changqing Yang; Saeid Golbidi; Mitsuru Irikura; Tetsumi Irie
Effects of bolus injection of soybean-based fat emulsion and fatty acids on pulmonary gas exchange function.
Biological & pharmaceutical bulletin 2009;32(3):500-3.
2008: Toru Takeo; Takayuki Hoshii; yuki kondo; Hiroshi Toyodome; Hidetoshi Arima; Ken-ichi Yamamura; Tetsumi Irie; Naomi Nakagata
Methyl-beta-cyclodextrin improves fertilizing ability of C57BL/6 mouse sperm after freezing and thawing by facilitating cholesterol efflux from the cells.
Biology of reproduction 2008;78(3):546-51.
2007: Tada Utsuki; Nao Uchimura; Mitsuru Irikura; Hiroshi Moriuchi; Harold W Holloway; Qian-Sheng Yu; Edward L Spangler; Jacek A Mamczarz; Donald Ingram; Tetsumi Irie; Nigel H Greig
Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy.
The Journal of pharmacology and experimental therapeutics 2007;321(1):353-61.
2006: Keiichi Motoyama; Hidetoshi Arima; Hiroshi Toyodome; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Effect of 2,6-di-O-methyl-alpha-cyclodextrin on hemolysis and morphological change in rabbit's red blood cells.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2006;29(2):111-9.
2004: Yoichi Ishitsuka; Hiroshi Moriuchi; Changqing Yang; Sumika Kurita; Saeid Golbidi; Mitsuru Irikura; Tetsumi Irie
Preventive effect of tranilast on oleic acid-induced lung injury in guinea pigs.
Biological & pharmaceutical bulletin 2004;27(9):1451-4.
2004: Yoichi Ishitsuka; Hiroshi Moriuchi; Keita Hatamoto; Changqing Yang; Junko Takase; Saeid Golbidi; Mitsuru Irikura; Tetsumi Irie
Involvement of thromboxane A2 (TXA2) in the early stages of oleic acid-induced lung injury and the preventive effect of ozagrel, a TXA2 synthase inhibitor, in guinea-pigs.
The Journal of pharmacy and pharmacology 2004;56(4):513-20.
2003: Changqing Yang; Hiroshi Moriuchi; Junko Takase; Yoichi Ishitsuka; Mitsuru Irikura; Tetsumi Irie
Oxidative stress in early stage of acute lung injury induced with oleic acid in guinea pigs.
Biological & pharmaceutical bulletin 2003;26(4):424-8.
2003: Saeid Golbidi; Hiroshi Moriuchi; Changqing Yang; Mitsuru Irikura; Tetsumi Irie; Naotaka Hamasaki
Preventive effect of phosphoenolpyruvate on hypoxemia induced by oleic acid in Guinea pigs.
Biological & pharmaceutical bulletin 2003;26(3):336-40.
2003: Kazuaki Matsumoto; Koji Nishi; Yoshiko Tokutomi; Tetsumi Irie; Ayaka Suenaga; Masaki Otagiri
Effects of alpha 1-acid glycoprotein on erythrocyte deformability and membrane stabilization.
Biological & pharmaceutical bulletin 2003;26(1):123-6.
2002: Yukihiko Nagase; M Hirata; Hidetoshi Arima; Shinichiro Tajiri; Y Nishimoto; Fumitoshi Hirayama; Tetsumi Irie; Kaneto Uekama
Protective effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced hemolysis in vitro.
Journal of pharmaceutical sciences 2002;91(11):2382-9.
2002: Saeid Golbidi; Hiroshi Moriuchi; Tetsumi Irie; Taghi Ghafghazi; Valiollah Hajhashemi
Involvement of calmodulin inhibition in analgesia induced with low doses of intrathecal trifluoperazine.
Japanese journal of pharmacology 2002;88(2):151-7.
2001: Yukihiko Nagase; M Hirata; K Wada; Hidetoshi Arima; Fumitoshi Hirayama; Tetsumi Irie; M Kikuchi; Kaneto Uekama
Improvement of some pharmaceutical properties of DY-9760e by sulfobutyl ether beta-cyclodextrin.
International journal of pharmaceutics 2001;229(1-2):163-72.
2001: Hidetoshi Arima; Kiyokazu Yunomae; K Miyake; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Comparative studies of the enhancing effects of cyclodextrins on the solubility and oral bioavailability of tacrolimus in rats.
Journal of pharmaceutical sciences 2001;90(6):690-701.
2000: K Tokihiro; Hidetoshi Arima; Shinichiro Tajiri; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Improvement of subcutaneous bioavailability of insulin by sulphobutyl ether beta-cyclodextrin in rats.
The Journal of pharmacy and pharmacology 2000;52(8):911-7.
1999: K Miyake; Tetsumi Irie; Hidetoshi Arima; Fumitoshi Hirayama; Kaneto Uekama; M Hirano; Y Okamaoto
Characterization of itraconazole/2-hydroxypropyl-beta-cyclodextrin inclusion complex in aqueous propylene glycol solution.
International journal of pharmaceutics 1999;179(2):237-45.
1999: K Miyake; Hidetoshi Arima; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Enhanced absorption of cyclosporin A by complexation with dimethyl-beta-cyclodextrin in bile duct-cannulated and -noncannulated rats.
Biological & pharmaceutical bulletin 1999;22(1):66-72.
1998: Hidetoshi Arima; T Miyaji; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Enhancing effect of hydroxypropyl-beta-cyclodextrin on cutaneous penetration and activation of ethyl 4-biphenylyl acetate in hairless mouse skin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;6(1):53-9.
1997: K Tokihiro; Tetsumi Irie; Kaneto Uekama
Varying effects of cyclodextrin derivatives on aggregation and thermal behavior of insulin in aqueous solution.
Chemical & pharmaceutical bulletin 1997;45(3):525-31.
1997: Tetsumi Irie; Kaneto Uekama
Pharmaceutical applications of cyclodextrins. III. Toxicological issues and safety evaluation.
Journal of pharmaceutical sciences 1997;86(2):147-62.
1996: Hidetoshi Arima; T Miyaji; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Possible enhancing mechanism of the cutaneous permeation of 4-biphenylylacetic acid by beta-cyclodextrin derivatives in hydrophilic ointment.
Chemical & pharmaceutical bulletin 1996;44(3):582-6.
1996: T Kondo; Tetsumi Irie; Kaneto Uekama
Combination effects of alpha-cyclodextrin and xanthan gum on rectal absorption and metabolism of morphine from hollow-type suppositories in rabbits.
Biological & pharmaceutical bulletin 1996;19(2):280-6.
1995: K Abe; Tetsumi Irie; Kaneto Uekama
Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-beta-cyclodextrin.
Chemical & pharmaceutical bulletin 1995;43(12):2232-7.
1995: H Sugiuchi; Y Uji; H Okabe; Tetsumi Irie; Kaneto Uekama; N Kayahara; K Miyauchi
Direct measurement of high-density lipoprotein cholesterol in serum with polyethylene glycol-modified enzymes and sulfated alpha-cyclodextrin.
Clinical chemistry 1995;41(5):717-23.
1995: K Shiotani; K Uehata; Tetsumi Irie; Kaneto Uekama; D O Thompson; Valentino J Stella
Differential effects of sulfate and sulfobutyl ether of beta-cyclodextrin on erythrocyte membranes in vitro.
Pharmaceutical research 1995;12(1):78-84.
1995: Kaneto Uekama; T Kondo; K Nakamura; Tetsumi Irie; K Arakawa; M Shibuya; J Tanaka
Modification of rectal absorption of morphine from hollow-type suppositories with a combination of alpha-cyclodextrin and viscosity-enhancing polysaccharide.
Journal of pharmaceutical sciences 1995;84(1):15-20.
1994: K Shiotani; K Uehata; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Characterization of the inclusion mode of beta-cyclodextrin sulfate and its effect on the chlorpromazine-induced hemolysis of rabbit erythrocytes.
Chemical & pharmaceutical bulletin 1994;42(11):2332-7.
1993: Kaneto Uekama; K Shiotami; Tetsumi Irie; Y Ishimaru; J Pitha
Protective effects of cyclodextrin sulphates against gentamicin-induced nephrotoxicity in the rat.
The Journal of pharmacy and pharmacology 1993;45(8):745-7.
1992: H Adachi; Tetsumi Irie; Kaneto Uekama; T Manako; T Yano; M Saita
Inhibitory effect of prostaglandin E1 on laurate-induced peripheral vascular occlusive sequelae in rabbits: optimized topical formulation with beta-cyclodextrin derivative and penetration enhancer HPE-101.
The Journal of pharmacy and pharmacology 1992;44(12):1033-5.
1992: Hidetoshi Arima; T Kondo; Tetsumi Irie; Kaneto Uekama
Enhanced rectal absorption and reduced local irritation of the anti-inflammatory drug ethyl 4-biphenylylacetate in rats by complexation with water-soluble beta-cyclodextrin derivatives and formulation as oleaginous suppository.
Journal of pharmaceutical sciences 1992;81(11):1119-25.
1992: Kaneto Uekama; H Adachi; Tetsumi Irie; T Yano; M Saita; K Noda
Improved transdermal delivery of prostaglandin E1 through hairless mouse skin: combined use of carboxymethyl-ethyl-beta-cyclodextrin and penetration enhancers.
The Journal of pharmacy and pharmacology 1992;44(2):119-21.
1992: Hidetoshi Arima; T Kondo; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama; T Miyaji; Y Inoue
[Use of water-soluble beta-cyclodextrin derivatives as carriers of anti-inflammatory drug biphenylylacetic acid in rectal delivery].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1992;112(1):65-72.
1990: Hidetoshi Arima; H Adachi; Tetsumi Irie; Kaneto Uekama; J Pitha
Enhancement of the antiinflammatory effect of ethyl 4-biphenylyl acetate in ointment by beta-cyclodextrin derivatives: increased absorption and localized activation of the prodrug in rats.
Pharmaceutical research 1990;7(11):1152-6.
1990: A Yoshida; M Yamamoto; T Itoh; Tetsumi Irie; Fumitoshi Hirayama; Kaneto Uekama
Utility of 2-hydroxypropyl-beta-cyclodextrin in an intramuscular injectable preparation of nimodipine.
Chemical & pharmaceutical bulletin 1990;38(1):176-9.
1989: Kaneto Uekama; Hidetoshi Arima; Tetsumi Irie; K Matsubara; T Kuriki
Sustained release of buserelin acetate, a luteinizing hormone-releasing hormone agonist, from an injectable oily preparation utilizing ethylated beta-cyclodextrin.
The Journal of pharmacy and pharmacology 1989;41(12):874-6.
1989: Kaneto Uekama; Y Horiuchi; Tetsumi Irie; Fumitoshi Hirayama
O-carboxymethyl-O-ethylcyclomaltoheptaose as a delayed-release-type drug carrier: improvement of the oral bioavailability of diltiazem in the dog.
Carbohydrate research 1989;192():323-30.
1989: T Hoshino; K Ishida; Tetsumi Irie; Kaneto Uekama; Tomomichi Ono
An attempt to reduce the photosensitizing potential of chlorpromazine with the simultaneous use of beta- and dimethyl-beta-cyclodextrins in guinea pigs.
Archives of dermatological research 1989;281(1):60-5.