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David Isenman

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Jean M H van den Elsen; David E Isenman
A crystal structure of the complex between human complement receptor 2 and its ligand C3d.
Teresia Hallström; Therese Nordstrom; Thuan Tong Tan; Taras Manolov; John D Lambris; David E Isenman; Peter F Zipfel; Anna Blom; Kristian Riesbeck
Immune evasion of Moraxella catarrhalis involves ubiquitous surface protein A-dependent C3d binding.
Tommi Kajander; Markus J Lehtinen; Satu Hyvärinen; Arnab Bhattacharjee; Elisa Leung; David E Isenman; Seppo Meri; Adrian Goldman; T Sakari Jokiranta
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.

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All Publications

2011: Jean M H van den Elsen; David E Isenman
A crystal structure of the complex between human complement receptor 2 and its ligand C3d.
Science (New York, N.Y.) 2011;332(6029):608-11.
2011: Teresia Hallström; Therese Nordstrom; Thuan Tong Tan; Taras Manolov; John D Lambris; David E Isenman; Peter F Zipfel; Anna Blom; Kristian Riesbeck
Immune evasion of Moraxella catarrhalis involves ubiquitous surface protein A-dependent C3d binding.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(5):3120-9.
2011: Tommi Kajander; Markus J Lehtinen; Satu Hyvärinen; Arnab Bhattacharjee; Elisa Leung; David E Isenman; Seppo Meri; Adrian Goldman; T Sakari Jokiranta
Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(7):2897-902.
2010: David E Isenman; Elisa Leung; Julia D Mackay; Stefan Bagby; Jean M H van den Elsen
Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.
Journal of immunology (Baltimore, Md. : 1950) 2010;184(4):1946-55.
2009: Markus J Lehtinen; Angelique L Rops; David E Isenman; Johan Van der Vlag; T. Sakari Jokiranta
Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome.
The Journal of biological chemistry 2009;284(23):15650-8.
2008: Hao Liu; Itay Shalev; Justin Manuel; Wei He; Elisa Leung; Jennifer Crookshank; Ming F Liu; Jun Diao; Mark Cattral; David A Clark; David E Isenman; Reginald M Gorczynski; David R Grant; Li Zhang; Melville J Phillips; Myron I Cybulsky; Gary A Levy
The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression.
European journal of immunology 2008;38(11):3114-26.
2008: Steve Bryson; Jean-Philippe Julien; David E Isenman; Renate Kunert; Hermann Katinger; Emil F Pai
Crystal structure of the complex between the F(ab)' fragment of the cross-neutralizing anti-HIV-1 antibody 2F5 and the F(ab) fragment of its anti-idiotypic antibody 3H6.
Journal of molecular biology 2008;382(4):910-9.
2008: Abhishek Upadhyay; Julia D Burman; Elizabeth A Clark; Elisa Leung; David E Isenman; Jean van den Elsen; Stefan Bagby
Structure-function analysis of the C3 binding region of Staphylococcus aureus immune subversion protein Sbi.
The Journal of biological chemistry 2008;283(32):22113-20.
2008: Julia D Burman; Elisa Leung; Karen L Atkins; Maghnus N O'Seaghdha; Lea Lango; Pau Bernadó; Stefan Bagby; Dmitri I Svergun; Timothy J Foster; David E Isenman; Jean van den Elsen
Interaction of human complement with Sbi, a staphylococcal immunoglobulin-binding protein: indications of a novel mechanism of complement evasion by Staphylococcus aureus.
The Journal of biological chemistry 2008;283(25):17579-93.
2006: Elisa Leung; Anna M Blom; Liliana Clemenza; David E Isenman
The complement regulator C4b-binding protein (C4BP) interacts with both the C4c and C4dg subfragments of the parent C4b ligand: evidence for synergy in C4BP subsite binding.
Biochemistry 2006;45(27):8378-92.
2006: Yunying Chen; Marko Sankala; Juha R M Ojala; Yi Sun; Ari Tuuttila; David E Isenman; Karl Tryggvason; Timo Pikkarainen
A phage display screen and binding studies with acetylated low density lipoprotein provide evidence for the importance of the scavenger receptor cysteine-rich (SRCR) domain in the ligand-binding function of MARCO.
The Journal of biological chemistry 2006;281(18):12767-75.
2004: Liliana Clemenza; David E Isenman
The C4A and C4B isotypic forms of human complement fragment C4b have the same intrinsic affinity for complement receptor 1 (CR1/CD35).
Journal of immunology (Baltimore, Md. : 1950) 2004;172(3):1670-80.
2002: Jean van den Elsen; Alberto Martin; Veronica Wong; Liliana Clemenza; David R Rose; David E Isenman
X-ray crystal structure of the C4d fragment of human complement component C4.
Journal of molecular biology 2002;322(5):1103-15.
2000: Liliana Clemenza; David E Isenman
Structure-guided identification of C3d residues essential for its binding to complement receptor 2 (CD21).
Journal of immunology (Baltimore, Md. : 1950) 2000;165(7):3839-48.
2000: Q Pan; R O Ebanks; David E Isenman
Two clusters of acidic amino acids near the NH2 terminus of complement component C4 alpha'-chain are important for C2 binding.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(5):2518-27.
1999: Alberto Martin; Hing Wo Tsui; Marc J Shulman; David E Isenman; Florence W L Tsui
Murine SHP-1 splice variants with altered Src homology 2 (SH2) domains. Implications for the SH2-mediated intramolecular regulation of SHP-1.
The Journal of biological chemistry 1999;274(31):21725-34.
1999: A E Oran; David E Isenman
Identification of residues within the 727-767 segment of human complement component C3 important for its interaction with factor H and with complement receptor 1 (CR1, CD35).
The Journal of biological chemistry 1999;274(8):5120-30.
1998: M Gadjeva; Alister W Dodds; A Taniguchi-Sidle; Antony C Willis; David E Isenman; S K Alex Law
The covalent binding reaction of complement component C3.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(2):985-90.
1998: Bhushan Nagar; Russell G Jones; Russell Diefenbach; David E Isenman; James M Rini
X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.
Science (New York, N.Y.) 1998;280(5367):1277-81.
1998: Lourdes Isaac; D Aivazian; A Taniguchi-Sidle; R O Ebanks; Chuck S Farah; Marlene P C Florido; M K Pangburn; David E Isenman
Native conformations of human complement components C3 and C4 show different dependencies on thioester formation.
The Biochemical journal 1998;329 ( Pt 3)():705-12.
1997: F H Chen; S K Arya; A Rinfret; David E Isenman; Marc J Shulman; R H Painter
Domain-switched mouse IgM/IgG2b hybrids indicate individual roles for C mu 2, C mu 3, and C mu 4 domains in the regulation of the interaction of IgM with complement C1q.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3354-63.
1996: R O Ebanks; David E Isenman
Mouse complement component C4 is devoid of classical pathway C5 convertase subunit activity.
Molecular immunology 1996;33(3):297-309.
1995: M J Wong; G Goldberger; David E Isenman; Joe O Minta
Processing of human factor I in COS-1 cells co-transfected with factor I and paired basic amino acid cleaving enzyme (PACE) cDNA.
Molecular immunology 1995;32(5):379-87.
1995: R O Ebanks; David E Isenman
Evidence for the involvement of arginine 462 and the flanking sequence of human C4 beta-chain in mediating C5 binding to the C4b subcomponent of the classical complement pathway C5 convertase.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(6):2808-20.
1995: Russell Diefenbach; David E Isenman
Mutation of residues in the C3dg region of human complement component C3 corresponding to a proposed binding site for complement receptor type 2 (CR2, CD21) does not abolish binding of iC3b or C3dg to CR2.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(5):2303-20.
1994: B Taylor; J F Wright; S Arya; David E Isenman; Marc J Shulman; R H Painter
C1q binding properties of monomer and polymer forms of mouse IgM mu-chain variants. Pro544Gly and Pro434Ala.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):5303-13.
1994: A Taniguchi-Sidle; David E Isenman
Interactions of human complement component C3 with factor B and with complement receptors type 1 (CR1, CD35) and type 3 (CR3, CD11b/CD18) involve an acidic sequence at the N-terminus of C3 alpha'-chain.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(11):5285-302.
1994: S Arya; F Chen; S Spycher; David E Isenman; Marc J Shulman; R H Painter
Mapping of amino acid residues in the C mu 3 domain of mouse IgM important in macromolecular assembly and complement-dependent cytolysis.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1206-12.
1993: M S Chappel; David E Isenman; R Oomen; Y Y Xu; MH Klein
Identification of a secondary Fc gamma RI binding site within a genetically engineered human IgG antibody.
The Journal of biological chemistry 1993;268(33):25124-31.
1992: Lourdes Isaac; David E Isenman
Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3.
The Journal of biological chemistry 1992;267(14):10062-9.
1992: R O Ebanks; A S Jaikaran; M C Carroll; M J Anderson; R D Campbell; David E Isenman
A single arginine to tryptophan interchange at beta-chain residue 458 of human complement component C4 accounts for the defect in classical pathway C5 convertase activity of allotype C4A6. Implications for the location of a C5 binding site in C4.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(9):2803-11.
1992: A Taniguchi-Sidle; David E Isenman
Mutagenesis of the Arg-Gly-Asp triplet in human complement component C3 does not abolish binding of iC3b to the leukocyte integrin complement receptor type III (CR3, CD11b/CD18).
The Journal of biological chemistry 1992;267(1):635-43.
1991: M S Chappel; David E Isenman; M Everett; Y Y Xu; K J Dorrington; MH Klein
Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(20):9036-40.
1990: J F Wright; Marc J Shulman; David E Isenman; R H Painter
C1 binding by mouse IgM. The effect of abnormal glycosylation at position 402 resulting from a serine to asparagine exchange at residue 406 of the mu-chain.
The Journal of biological chemistry 1990;265(18):10506-13.
1988: J F Wright; Marc J Shulman; David E Isenman; R H Painter
C1 binding by murine IgM. The effect of a Pro-to-Ser exchange at residue 436 of the mu-chain.
The Journal of biological chemistry 1988;263(23):11221-6.
1988: C Domenicucci; H A Goldberg; T Hofmann; David E Isenman; S Wasi; Jaro Sodek
Characterization of porcine osteonectin extracted from foetal calvariae.
The Biochemical journal 1988;253(1):139-51.
1988: E L Pryzdial; David E Isenman
A thermodynamic study of the interaction between human complement components C3b or C3(H2O) and factor B in solution.
The Journal of biological chemistry 1988;263(4):1733-8.
1987: S E Spycher; S Arya; David E Isenman; R H Painter
A functional, thioester-containing alpha 2-macroglobulin homologue isolated from the hemolymph of the American lobster (Homarus americanus).
The Journal of biological chemistry 1987;262(30):14606-11.
1987: Joe O Minta; David E Isenman
Biosynthesis of the third component of complement by the human monocyte-like cell line, U-937.
Molecular immunology 1987;24(10):1105-11.
1987: E L Pryzdial; David E Isenman
Alternative complement pathway activation fragment Ba binds to C3b. Evidence that formation of the factor B-C3b complex involves two discrete points of contact.
The Journal of biological chemistry 1987;262(4):1519-25.
1987: Gabrielle L Boulianne; David E Isenman; N Hozumi; Marc J Shulman
Biological properties of chimeric antibodies. Interaction with complement.
Molecular biology & medicine 1987;4(1):37-49.
1986: E L Pryzdial; David E Isenman
A reexamination of the role of magnesium in the human alternative pathway of complement.
Molecular immunology 1986;23(1):87-96.
1985: K J Dorrington; David E Isenman; MH Klein; R H Painter; D G Romans
Biological role of IgG hinge region.
Nature 1985;314(6011):500.
1984: P A Hamel; David E Isenman; MH Klein; R Luedtke; K J Dorrington
Structural basis for the preferential association of autologous immunoglobulin subunits: role of the J region of the light chain.
Molecular immunology 1984;21(4):277-83.
1983: Joe O Minta; M B Urowitz; H A Smythe; David E Isenman
Effect on the human complement system of the major non-steroidal anti-inflammatory drugs: aspirin, indomethacin, phenylbutazone, oxyphenbutazone and sulindac.
Clinical and experimental immunology 1983;53(3):555-61.
1982: David E Isenman; D I Kells
Conformational and functional changes in the fourth component of human complement produced by nucleophilic modification and by proteolysis with C1s-.
Biochemistry 1982;21(6):1109-17.
1981: J E Marks; David E Isenman; R H Painter
The use of diafiltration for the measurement of dialysable ligand binding to macromolecules: an examination of the theoretical parameters using concanavalin A in an Amicon cell.
Canadian journal of biochemistry 1981;59(11-12):893-8.
1981: David E Isenman; D I Kells; N R Cooper; H J Müller-Eberhard; M K Pangburn
Nucleophilic modification of human complement protein C3: correlation of conformational changes with acquisition of C3b-like functional properties.
Biochemistry 1981;20(15):4458-67.
1981: M Klein; Nicole Haeffner-Cavaillon; David E Isenman; C Rivat; M A Navia; D R Davies; K J Dorrington
Expression of biological effector functions by immunoglobulin G molecules lacking the hinge region.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(1):524-8.