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Shun Ishibashi

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Hiroaki Yagyu; Michiaki Miyamoto; Shuichi Nagashima; Kenta Okada; Jun-Ichi Osuga; Manabu Takahashi; Shun Ishibashi
Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.
Shuichi Nagashima; Ken Ohashi; Taichi Ohshiro; Kenta Okada; Jun-ichi Osuga; Motohiro Sekiya; Manabu Takahashi; Fumiko Tazoe; Hiroaki Yagyu; Tumenbayar Bayasgalan; Shun Ishibashi
Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
Hitomi Ogata; Zbigniew R Struzik; Hiroaki Suzuki; Kumpei Tokuyama; Takeshi Tsuchita; Nobuhiro Yamada; Kumiko Hamano; Shun Ishibashi; Ken Kiyono; Ikuyo Kusaka; Shoichiro Nagasaka; Yoshiharu Yamamoto
The lack of long-range negative correlations in glucose dynamics is associated with worse glucose control in patients with diabetes mellitus.

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2012: Hiroaki Yagyu; Michiaki Miyamoto; Shuichi Nagashima; Kenta Okada; Jun-Ichi Osuga; Manabu Takahashi; Shun Ishibashi
Ezetimibe, an inhibitor of Niemann-Pick C1-like 1 protein, decreases cholesteryl ester transfer protein in type 2 diabetes mellitus.
Endocrine journal 2012;59(12):1077-84.
2012: Shuichi Nagashima; Ken Ohashi; Taichi Ohshiro; Kenta Okada; Jun-ichi Osuga; Motohiro Sekiya; Manabu Takahashi; Fumiko Tazoe; Hiroaki Yagyu; Tumenbayar Bayasgalan; Shun Ishibashi
Liver-specific deletion of 3-hydroxy-3-methylglutaryl coenzyme A reductase causes hepatic steatosis and death.
Arteriosclerosis, thrombosis, and vascular biology 2012;32(8):1824-31.
2012: Hitomi Ogata; Zbigniew R Struzik; Hiroaki Suzuki; Kumpei Tokuyama; Takeshi Tsuchita; Nobuhiro Yamada; Kumiko Hamano; Shun Ishibashi; Ken Kiyono; Ikuyo Kusaka; Shoichiro Nagasaka; Yoshiharu Yamamoto
The lack of long-range negative correlations in glucose dynamics is associated with worse glucose control in patients with diabetes mellitus.
Metabolism: clinical and experimental 2012;61(7):1041-50.
2012: Hirohito Sone; Sachiko Tanaka; Shiro Tanaka; Nobuhiro Yamada; Yasuo Akanuma; Satoshi Iimuro; Shun Ishibashi; Shigehiro Katayama; Yasuo Ohashi; Shinichi Oikawa; Hitoshi Shimano
Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study.
Diabetes care 2012;35(5):1150-7.
2012: Hiroaki Yagyu; Yumiko Yamashita; Shoichiro Nagasaka; Kenta Okada; Nobukazu Okada; Jun-ichi Osuga; Shin Sato; Kentaro Sugano; Shun Ishibashi
Pegylated interferon-α2b and ribavirin combination therapy induces Hashitoxicosis followed by type 1 diabetes mellitus.
Diabetes research and clinical practice 2012;95(3):e52-4.
2011: Keisuke Ohta; Motohiro Sekiya; Hiroshi Uozaki; Masaki Igarashi; Satoru Takase; Masayoshi Kumagai; Masakatsu Takanashi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Makiko Nishi; Hiroaki Okazaki; Yoko Iizuka; Naoya Yahagi; Hiroaki Yagyu; Masashi Fukayama; Takashi Kadowaki; Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga
Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement.
Biochemical and biophysical research communications 2011;404(1):254-60.
2011: Motohiro Sekiya; Jun-ichi Osuga; Masaki Igarashi; Hiroaki Okazaki; Shun Ishibashi
The role of neutral cholesterol ester hydrolysis in macrophage foam cells.
Journal of atherosclerosis and thrombosis 2011;18(5):359-64.
2010: Kazuhiro Eto; Bayasgalan Tumenbayar; Shu-ichi Nagashima; Fumiko Tazoe; Michiaki Miyamoto; Manabu Takahashi; Akihiko Ando; Kenta Okada; Hiroaki Yagyu; Shun Ishibashi
Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes.
Diabetes research and clinical practice 2010;89(1):52-7.
2010: Masaki Igarashi; Jun-ichi Osuga; Masashi Isshiki; Motohiro Sekiya; Hiroaki Okazaki; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Masayoshi Kumagai; Makiko Nishi; Toshiro Fujita; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi
Targeting of neutral cholesterol ester hydrolase to the endoplasmic reticulum via its N-terminal sequence.
Journal of lipid research 2010;51(2):274-85.
2009: Motohiro Sekiya; Naoya Yahagi; Yoshiaki Tamura; Hiroaki Okazaki; Masaki Igarashi; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Satoru Takase; Makiko Nishi; Yoshinori Takeuchi; Yoshihiko Izumida; Midori Kubota; Ken Ohashi; Yoko Iizuka; Hiroaki Yagyu; Takanari Gotoda; Ryozo Nagai; Hitoshi Shimano; Nobuhiro Yamada; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
Biochemical and biophysical research communications 2009;387(3):511-5.
2009: Motohiro Sekiya; Jun-ichi Osuga; Shuichi Nagashima; Taichi Ohshiro; Masaki Igarashi; Hiroaki Okazaki; Manabu Takahashi; Fumiko Tazoe; Taeko Wada; Keisuke Ohta; Mikio Takanashi; Masayoshi Kumagai; Makiko Nishi; Satoru Takase; Naoya Yahagi; Hiroaki Yagyu; Ken Ohashi; Ryozo Nagai; Takashi Kadowaki; Yusuke Furukawa; Shun Ishibashi
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.
Cell metabolism 2009;10(3):219-28.
2009: Hirohito Sone; Sachiko Tanaka; Satoshi Iimuro; Koji Oida; Yoshimitsu Yamasaki; Shinichi Oikawa; Shun Ishibashi; Shigehiro Katayama; Hideki Ito; Yasuo Ohashi; Yasuo Akanuma; Nobuhiro Yamada
Components of metabolic syndrome and their combinations as predictors of cardiovascular disease in Japanese patients with type 2 diabetes. Implications for improved definition. Analysis from Japan Diabetes Complications Study (JDCS).
Journal of atherosclerosis and thrombosis 2009;16(4):380-7.
2009: Hirohito Sone; Shiro Tanaka; Satoshi Iimuro; Koji Oida; Yoshimitsu Yamasaki; Shun Ishibashi; Shinichi Oikawa; Shigehiro Katayama; Hideki Ito; Yasuo Ohashi; Yasuo Akanuma; Nobuhiro Yamada
Waist circumference as a cardiovascular and metabolic risk in Japanese patients with type 2 diabetes.
Obesity (Silver Spring, Md.) 2009;17(3):585-92.
2008: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Motohiro Sekiya; Makiko Tajima; Satoru Takase; Mikio Takanashi; Keisuke Ohta; Yoshiaki Tamura; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Michiyo Amemiya-Kudo; Yoshimi Nakagawa; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages.
The Journal of biological chemistry 2008;283(48):33357-64.
2008: Fumiko Tazoe; Hiroaki Yagyu; Hiroaki Okazaki; Masaki Igarashi; Kazuhiro Eto; Shu-Ichi Nagashima; Toshihiro Inaba; Hitoshi Shimano; Jun-ichi Osuga; Shun Ishibashi
Induction of ABCA1 by overexpression of hormone-sensitive lipase in macrophages.
Biochemical and biophysical research communications 2008;376(1):111-5.
2008: Ikuyo Kusaka; Shoichiro Nagasaka; H Horie; Shun Ishibashi
Metformin, but not pioglitazone, decreases postchallenge plasma ghrelin levels in type 2 diabetic patients: a possible role in weight stability?
Diabetes, obesity & metabolism 2008;10(11):1039-46.
2008: Akio Kawakami; Nobukazu Okada; Kumiko Rokkaku; Kazufumi Honda; Shun Ishibashi; Tatsushi Onaka
Leptin inhibits and ghrelin augments hypothalamic noradrenaline release after stress.
Stress (Amsterdam, Netherlands) 2008;11(5):363-9.
2008: Motohiro Sekiya; Jun-ichi Osuga; Naoya Yahagi; Hiroaki Okazaki; Yoshiaki Tamura; Masaki Igarashi; Satoru Takase; Kenji Harada; Sachiko Okazaki; Yoko Iizuka; Ken Ohashi; Hiroaki Yagyu; Mitsuyo Okazaki; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis.
Journal of lipid research 2008;49(8):1829-38.
2008: Toshihiro Inaba; Hiroaki Yagyu; Naoki Itabashi; Fumiko Tazoe; Nobuya Fujita; Shu-ichi Nagashima; Koji Okada; Mitsuyo Okazaki; Yusuke Furukawa; Shun Ishibashi
Cholesterol reduction and atherosclerosis inhibition by bezafibrate in low-density lipoprotein receptor knockout mice.
Hypertension research : official journal of the Japanese Society of Hypertension 2008;31(5):999-1005.
2008: Yoshitaka Iwazu; Shigeaki Muto; Genro Fujisawa; Eiko Nakazawa; Koji Okada; Shun Ishibashi; Eiji Kusano
Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis.
Hypertension 2008;51(3):749-54.
2007: Hirohito Sone; Yukio Yoshimura; Sachiko Tanaka; Satoshi Iimuro; Yasuo Ohashi; Hideki Ito; Hiroaki Seino; Shun Ishibashi; Yasuo Akanuma; Nobuhiro Yamada
Cross-sectional association between BMI, glycemic control and energy intake in Japanese patients with type 2 diabetes. Analysis from the Japan Diabetes Complications Study.
Diabetes research and clinical practice 2007;77 Suppl 1():S23-9.
2007: Shuichi Nagashima; Hiroaki Yagyu; Shun Ishibashi
[Abnormalities of the enzymes involved in lipid metabolism].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():93-9.
2007: Fumiko Tazoe; Hiroaki Yagyu; Shun Ishibashi
[Functions of enzymes involved in lipid metabolism].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 7():26-30.
2007: Motohiro Sekiya; Naoya Yahagi; Takashi Matsuzaka; Yoshinori Takeuchi; Yoshimi Nakagawa; Haruka Takahashi; Hiroaki Okazaki; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Shun Ishibashi; Ryozo Nagai; Tsutomu Yamazaki; Takashi Kadowaki; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
SREBP-1-independent regulation of lipogenic gene expression in adipocytes.
Journal of lipid research 2007;48(7):1581-91.
2007: H Ogata; Kumpei Tokuyama; S Nagasaka; A Ando; I Kusaka; N Sato; A Goto; Shun Ishibashi; Ken Kiyono; Zbigniew R Struzik; Yoshiharu Yamamoto
Long-range correlated glucose fluctuations in diabetes.
Methods of information in medicine 2007;46(2):222-6.
2006: Hitomi Ogata; Kumpei Tokuyama; Shoichiro Nagasaka; Akihiko Ando; Ikuyo Kusaka; Naoko Sato; Akiko Goto; Shun Ishibashi; Ken Kiyono; Zbigniew R Struzik; Yoshiharu Yamamoto
Long-range negative correlation of glucose dynamics in humans and its breakdown in diabetes mellitus.
American journal of physiology. Regulatory, integrative and comparative physiology 2006;291(6):R1638-43.
2006: Shun Ishibashi
[Management of blood glucose--target of the management and its practice].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(11):2089-94.
2006: Genro Fujisawa; Shigeaki Muto; Koji Okada; Eiji Kusano; Shun Ishibashi
Mineralocorticoid receptor antagonist spironolactone prevents pig serum-induced hepatic fibrosis in rats.
Translational research : the journal of laboratory and clinical medicine 2006;148(3):149-56.
2006: Hiroaki Okazaki; Fumiko Tazoe; Sachiko Okazaki; Noriko Isoo; Kazuhisa Tsukamoto; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Tetsuya Kitamine; Ryuichi Tozawa; Toshihiro Inaba; Hiroaki Yagyu; Mitsuyo Okazaki; Hitoshi Shimano; Norihito Shibata; Hiroyuki Arai; Ryo-Zo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver.
Journal of lipid research 2006;47(9):1950-8.
2006: Masumi Hara; Naoyuki Iso-o; Hiroaki Satoh; Hiroshi Noto; Masako Togo; Shun Ishibashi; Satoshi Kimura; Takashi Kadowaki; Yoshiaki Hashimoto; Kazuhisa Tsukamoto
Differential effects of apolipoprotein E isoforms on lipolysis of very low-density lipoprotein triglycerides.
Metabolism: clinical and experimental 2006;55(8):1129-34.
2006: Hiroaki Okazaki; Masaki Igarashi; Makiko Nishi; Makiko Tajima; Motohiro Sekiya; Sachiko Okazaki; Naoya Yahagi; Ken Ohashi; Kazuhisa Tsukamoto; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Hitoshi Shimano; Nobuhiro Yamada; Junken Aoki; Rei Morikawa; Yasukazu Takanezawa; Hiroyuki Arai; Ryozo Nagai; Takashi Kadowaki; Jun-ichi Osuga; Shun Ishibashi
Identification of a novel member of the carboxylesterase family that hydrolyzes triacylglycerol: a potential role in adipocyte lipolysis.
Diabetes 2006;55(7):2091-7.
2006: Jian Mei Yang; Shoichiro Nagasaka; Toshimitsu Yatagai; Tomoatsu Nakamura; Ikuyo Kusaka; San-e Ishikawa; Toshikazu Saito; Shun Ishibashi
Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes.
Diabetes research and clinical practice 2006;71(2):164-9.
2006: Hirohito Sone; Sachiko Tanaka; Shun Ishibashi; Yoshimitsu Yamasaki; Shinichi Oikawa; Hideki Ito; Yasushi Saito; Yasuo Ohashi; Yasuo Akanuma; Nobuhiro Yamada
The new worldwide definition of metabolic syndrome is not a better diagnostic predictor of cardiovascular disease in Japanese diabetic patients than the existing definitions: additional analysis from the Japan Diabetes Complications Study.
Diabetes care 2006;29(1):145-7.
2005: Satoshi Shinozaki; Naoki Itabashi; Kumiko Rokkaku; Kenji Ichiki; Shoichiro Nagasaka; Koji Okada; Mitsuo Fujimoto; Mamitaro Ohtsuki; Shun Ishibashi
Diabetic lipemia with eruptive xanthomatosis in a lean young female with apolipoprotein E4/4.
Diabetes research and clinical practice 2005;70(2):183-92.
2005: Michiyo Amemiya-Kudo; Junko Oka; Tomohiro Ide; Takashi Matsuzaka; Hirohito Sone; Tomohiro Yoshikawa; Naoya Yahagi; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada; Toshio Murase; Hitoshi Shimano
Sterol regulatory element-binding proteins activate insulin gene promoter directly and indirectly through synergy with BETA2/E47.
The Journal of biological chemistry 2005;280(41):34577-89.
2005: Yuho Najima; Naoya Yahagi; Yoshinori Takeuchi; Takashi Matsuzaka; Motohiro Sekiya; Yoshimi Nakagawa; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Sachiko Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Nobuhiro Yamada; Jun-ichi Osuga; Hitoshi Shimano
High mobility group protein-B1 interacts with sterol regulatory element-binding proteins to enhance their DNA binding.
The Journal of biological chemistry 2005;280(30):27523-32.
2005: Hirohito Sone; Sachiko Mizuno; Hitomi Fujii; Yukio Yoshimura; Yoshimitsu Yamasaki; Shun Ishibashi; Shigehiro Katayama; Yasushi Saito; Hideki Ito; Yasuo Ohashi; Yasuo Akanuma; Nobuhiro Yamada
Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study.
Diabetes care 2005;28(6):1463-71.
2005: Naoya Yahagi; Hitoshi Shimano; Kiyoshi Hasegawa; Ken Ohashi; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Kenichi Ohashi; Ryozo Nagai; Shun Ishibashi; Takashi Kadowaki; Makuuchi Masatoshi; Shin Ohnishi; Jun-ichi Osuga; Nobuhiro Yamada
Co-ordinate activation of lipogenic enzymes in hepatocellular carcinoma.
European journal of cancer (Oxford, England : 1990) 2005;41(9):1316-22.
2005: Gesine Saher; Britta Brügger; Corinna Lappe-Siefke; Wiebke Möbius; Ryuichi Tozawa; Michael C Wehr; Felix T Wieland; Shun Ishibashi; Klaus-Armin Nave
High cholesterol level is essential for myelin membrane growth.
Nature neuroscience 2005;8(4):468-75.
2004: Shun Ishibashi
[LDL receptor activity].
Nihon rinsho. Japanese journal of clinical medicine 2004;62 Suppl 12():130-3.
2004: Genro Fujisawa; Koji Okada; Shigeaki Muto; Nobuya Fujita; Naoki Itabashi; Eiji Kusano; Shun Ishibashi
Spironolactone prevents early renal injury in streptozotocin-induced diabetic rats.
Kidney international 2004;66(4):1493-502.
2004: Yoshiaki Tamura; Jun-ichi Osuga; Hideki Adachi; Ryuichi Tozawa; Yasukazu Takanezawa; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hiroyuki Koizumi; Toshihiro Inaba; Hiroaki Yagyu; Nobuo Kamada; Hiroshi Suzuki; Hitoshi Shimano; Takashi Kadowaki; Masafumi Tsujimoto; Hiroyuki Arai; Nobuhiro Yamada; Shun Ishibashi
Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide.
The Journal of biological chemistry 2004;279(30):30938-44.
2004: Masataka Sata; Hiroaki Nishimatsu; Jun-ichi Osuga; Kimie Tanaka; Nobukazu Ishizaka; Shun Ishibashi; Yasunobu Hirata; Ryozo Nagai
Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis.
Hypertension 2004;43(6):1214-20.
2004: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Motohiro Sekiya; Yuho Najima; Sachiko Okazaki; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Noriyuki Inoue; Yoshimi Nakagawa; Yoshinori Takeuchi; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Takashi Kadowaki; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 involvement in the pathogenesis of fatty liver disease.
The Journal of biological chemistry 2004;279(20):20571-5.
2004: Motohiro Sekiya; Jun-ichi Osuga; Hiroaki Okazaki; Naoya Yahagi; Kenji Harada; Wen-Jun Shen; Yoshiaki Tamura; Sachiko Tomita; Yoko Iizuka; Ken Ohashi; Mitsuyo Okazaki; Masataka Sata; Ryozo Nagai; Toshiro Fujita; Hitoshi Shimano; Fredric B Kraemer; Nobuhiro Yamada; Shun Ishibashi
Absence of hormone-sensitive lipase inhibits obesity and adipogenesis in Lep ob/ob mice.
The Journal of biological chemistry 2004;279(15):15084-90.
2004: Tomoatsu Nakamura; Masami Murakami; Hisashi Horiguchi; Shoichiro Nagasaka; Shun Ishibashi; Masatomo Mori; San-e Ishikawa
A case of thymic enlargement in hyperthyroidism in a young woman.
Thyroid : official journal of the American Thyroid Association 2004;14(4):307-10.
2004: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Sachiko Tomita; Motohiro Sekiya; Alyssa H Hasty; Yoshimi Nakagawa; Hirohito Sone; Hideo Toyoshima; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
Insulin-independent induction of sterol regulatory element-binding protein-1c expression in the livers of streptozotocin-treated mice.
Diabetes 2004;53(3):560-9.
2004: Shoichiro Nagasaka; Y Aiso; K Yoshizawa; Shun Ishibashi
Comparison of pioglitazone and metformin efficacy using homeostasis model assessment.
Diabetic medicine : a journal of the British Diabetic Association 2004;21(2):136-41.
2004: Hideaki Bujo; Kazuo Takahashi; Yasushi Saito; Takao Maruyama; Shizuya Yamashita; Yuji Matsuzawa; Shun Ishibashi; Futoshi Shionoiri; Nobuhiro Yamada; Toru Kita
Clinical features of familial hypercholesterolemia in Japan in a database from 1996-1998 by the research committee of the ministry of health, labour and welfare of Japan.
Journal of atherosclerosis and thrombosis 2004;11(3):146-51.
2004: Takao Maruyama; Shizuya Yamashita; Yuji Matsuzawa; Hideaki Bujo; Kazuo Takahashi; Yasushi Saito; Shun Ishibashi; Ken Ohashi; Futoshi Shionoiri; Takanari Gotoda; Nobuhiro Yamada; Toru Kita
Mutations in Japanese subjects with primary hyperlipidemia--results from the Research Committee of the Ministry of Health and Welfare of Japan since 1996--.
Journal of atherosclerosis and thrombosis 2004;11(3):131-45.
2004: Toshimitsu Yatagai; Tomoatsu Nakamura; Shoichiro Nagasaka; Ikuyo Kusaka; San-e Ishikawa; Aiso Yoshitaka; Shun Ishibashi
Decrease in serum C-reactive protein levels by troglitazone is associated with pretreatment insulin resistance, but independent of its effect on glycemia, in type 2 diabetic subjects.
Diabetes research and clinical practice 2004;63(1):19-26.
2003: Manabu Ogura; Ikuyo Kusaka; Shoichiro Nagasaka; Toshimitsu Yatagai; Satoshi Shinozaki; Naoki Itabashi; Tomoatsu Nakamura; Mizue Yokoyama; San-e Ishikawa; Shun Ishibashi
Unilateral adrenalectomy improves insulin resistance and diabetes mellitus in a patient with ACTH-independent macronodular adrenal hyperplasia.
Endocrine journal 2003;50(6):715-21.
2003: Motohiro Sekiya; Naoya Yahagi; Takashi Matsuzaka; Yuho Najima; Masanori Nakakuki; Ryozo Nagai; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada; Hitoshi Shimano
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression.
Hepatology (Baltimore, Md.) 2003;38(6):1529-39.
2003: Ken Ohashi; Jun-ichi Osuga; Ryuichi Tozawa; Tetsuya Kitamine; Hiroaki Yagyu; Motohiro Sekiya; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Naoya Yahagi; Yoko Iizuka; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Early embryonic lethality caused by targeted disruption of the 3-hydroxy-3-methylglutaryl-CoA reductase gene.
The Journal of biological chemistry 2003;278(44):42936-41.
2003: Kumiko Rokkaku; Tatsushi Onaka; Nobukazu Okada; Junichi Ideno; Akio Kawakami; Kazufumi Honda; Toshihiko Yada; Shun Ishibashi
Neuromedin U facilitates oxytocin release from the pituitary via beta adrenoceptors.
Neuroreport 2003;14(15):1997-2000.
2003: Toshimitsu Yatagai; Shoichiro Nagasaka; Ataru Taniguchi; Mitsuo Fukushima; Tomoatsu Nakamura; Akira Kuroe; Yoshikatsu Nakai; Shun Ishibashi
Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus.
Metabolism: clinical and experimental 2003;52(10):1274-8.
2003: Naoya Yahagi; Hitoshi Shimano; Takashi Matsuzaka; Yuho Najima; Motohiro Sekiya; Yoshimi Nakagawa; Tomohiro Ide; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Takanari Gotoda; Ryozo Nagai; Satoshi Kimura; Shun Ishibashi; Jun-ichi Osuga; Nobuhiro Yamada
p53 Activation in adipocytes of obese mice.
The Journal of biological chemistry 2003;278(28):25395-400.
2003: Shoichiro Nagasaka; Ataru Taniguchi; Yoshitaka Aiso; Toshimitsu Yatagai; Tomoatsu Nakamura; Yoshikatsu Nakai; Mitsuo Fukushima; Akira Kuroe; Shun Ishibashi
Effect of glimepiride on serum adiponectin level in subjects with type 2 diabetes.
Diabetes care 2003;26(7):2215-6.
2003: Tomohiro Ide; Hitoshi Shimano; Tomohiro Yoshikawa; Naoya Yahagi; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Masanori Nakakuki; Shigeru Yatoh; Yoko Iizuka; Sachiko Tomita; Ken Ohashi; Akimitsu Takahashi; Hirohito Sone; Takanari Gotoda; Jun-ichi Osuga; Shun Ishibashi; Nobuhiro Yamada
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1255-67.
2003: Tomohiro Yoshikawa; Tomohiro Ide; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Shigeru Yatoh; Tetsuya Kitamine; Hiroaki Okazaki; Yoshiaki Tamura; Motohiro Sekiya; Akimitsu Takahashi; Alyssa H Hasty; Ryuichiro Sato; Hirohito Sone; Jun-ichi Osuga; Shun Ishibashi; Nobuhiro Yamada
Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
Molecular endocrinology (Baltimore, Md.) 2003;17(7):1240-54.
2003: Tomoatsu Nakamura; Shoichiro Nagasaka; Ikuyo Kusaka; Toshimitsu Yatagai; Jianmei Yang; Shun Ishibashi
HLA-DR-DQ haplotype in rapid-onset type 1 diabetes in Japanese.
Diabetes care 2003;26(5):1640-1.
2003: Yoshiaki Tamura; Hideki Adachi; Jun-ichi Osuga; Ken Ohashi; Naoya Yahagi; Motohiro Sekiya; Hiroaki Okazaki; Sachiko Tomita; Yoko Iizuka; Hitoshi Shimano; Ryozo Nagai; Satoshi Kimura; Masafumi Tsujimoto; Shun Ishibashi
FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products.
The Journal of biological chemistry 2003;278(15):12613-7.
2003: Toshimitsu Yatagai; Yuichiro Nishida; Shoichiro Nagasaka; Tomoatsu Nakamura; Kumpei Tokuyama; Munehiro Shindo; Hiroaki Tanaka; Shun Ishibashi
Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men.
Endocrine journal 2003;50(2):233-8.
2003: Genro Fujisawa; Koji Okada; Shigeaki Muto; Nobuya Fujita; Naoki Itabashi; Eiji Kusano; Shun Ishibashi
Na/H exchange isoform 1 is involved in mineralocorticoid/salt-induced cardiac injury.
Hypertension 2003;41(3):493-8.
2003: Toshimitsu Yatagai; Ikuyo Kusaka; Tomoatsu Nakamura; Shoichiro Nagasaka; Kazufumi Honda; Shun Ishibashi; San-e Ishikawa
Close association of severe hyponatremia with exaggerated release of arginine vasopressin in elderly subjects with secondary adrenal insufficiency.
European journal of endocrinology / European Federation of Endocrine Societies 2003;148(2):221-6.
2002: Hiroaki Okazaki; Jun-ichi Osuga; Yoshiaki Tamura; Naoya Yahagi; Sachiko Tomita; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Kenji Harada; Satoshi Kimura; Takanari Gotoda; Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi
Lipolysis in the absence of hormone-sensitive lipase: evidence for a common mechanism regulating distinct lipases.
Diabetes 2002;51(12):3368-75.
2002: Tomoatsu Nakamura; Takako Saito; Ikuyo Kusaka; Minori Higashiyama; Shoichiro Nagasaka; Shun Ishibashi; San-e Ishikawa
Decrease in urinary excretion of aquaporin-2 associated with impaired urinary concentrating ability in diabetic nephropathy.
Nephron 2002;92(2):445-8.
2002: Shun Ishibashi
[Guideline for management of lipid metabolism].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():675-8.
2002: H Sone; A Katagiri; Shun Ishibashi; R Abe; Y Saito; T Murase; H Yamashita; Y Yajima; H Ito; Y Ohashi; Y Akanuma; Nobuhiro Yamada
Effects of lifestyle modifications on patients with type 2 diabetes: the Japan Diabetes Complications Study (JDCS) study design, baseline analysis and three year-interim report.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2002;34(9):509-15.
2002: K Ichiki; Tomoatsu Nakamura; N Fujita; Kazufumi Honda; T Hiraga; Shun Ishibashi; San-e Ishikawa
An endocrinopathy characterized by dysfunction of the pituitary-adrenal axis and alopecia universalis: supporting the entity of a triple H syndrome.
European journal of endocrinology / European Federation of Endocrine Societies 2002;147(3):357-61.
2002: Hiroaki Okazaki; Jun-ichi Osuga; Kazuhisa Tsukamoto; Noriko Isoo; Tetsuya Kitamine; Yoshiaki Tamura; Sachiko Tomita; Motohiro Sekiya; Naoya Yahagi; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Satoshi Kimura; Ryozo Nagai; Nobuhiro Yamada; Shun Ishibashi
Elimination of cholesterol ester from macrophage foam cells by adenovirus-mediated gene transfer of hormone-sensitive lipase.
The Journal of biological chemistry 2002;277(35):31893-9.
2002: Yoshiaki Tamura; Shun Ishibashi; Takanari Gotoda; Junko Yasufuku-Takano; Koji Takano; Keisuke Ueki; Shigeo Yamashita; Yoko Iizuka; Naoya Yahagi; Futoshi Shionoiri; Hiroaki Okazaki; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Hitoshi Shimano; Toshiro Fujita; Nobuhiro Yamada; Satoshi Kimura
A kindred of familial acromegaly without evidence for linkage to MEN-1 locus.
Endocrine journal 2002;49(4):425-31.
2002: Michiyo Amemiya-Kudo; Hitoshi Shimano; Alyssa H Hasty; Naoya Yahagi; Tomohiro Yoshikawa; Takashi Matsuzaka; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryuichiro Sato; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.
Journal of lipid research 2002;43(8):1220-35.
2002: Yasushi Imai; Takayuki Shindo; Koji Maemura; Masataka Sata; Yuichiro Saito; Yukiko Kurihara; Masahiro Akishita; Jun-ichi Osuga; Shun Ishibashi; Kazuyuki Tobe; Hiroyuki Morita; Yoshio Oh-hashi; Toru Suzuki; Hiromitsu Maekawa; Kenji Kangawa; Naoto Minamino; Yoshio Yazaki; Ryozo Nagai; Hiroki Kurihara
Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(8):1310-5.
2002: Akihiko Ando; Toshimitsu Yatagai; Kumiko Rokkaku; Shoichiro Nagasaka; San-e Ishikawa; Shun Ishibashi
Obesity is a critical risk factor for worsening of glucose tolerance in a family with the mutant insulin receptor.
Diabetes care 2002;25(8):1484-5.
2002: Nobuya Fujita; Yusuke Furukawa; Naoki Itabashi; Koji Okada; Toshikazu Saito; Shun Ishibashi
Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells.
American journal of physiology. Heart and circulatory physiology 2002;283(1):H204-12.
2002: Nobuya Fujita; Yusuke Furukawa; Jian Du; Naoki Itabashi; Genro Fujisawa; Koji Okada; Toshikazu Saito; Shun Ishibashi
Hyperglycemia enhances VSMC proliferation with NF-kappaB activation by angiotensin II and E2F-1 augmentation by growth factors.
Molecular and cellular endocrinology 2002;192(1-2):75-84.
2002: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Alyssa H Hasty; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Akimitsu Takahashi; Shigeru Yato; Hirohito Sone; Shun Ishibashi; Nobuhiro Yamada
Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs.
Journal of lipid research 2002;43(6):911-20.
2002: Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Takashi Matsuzaka; Tomohiro Ide; Tomohiro Yoshikawa; Michiyo Amemiya-Kudo; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice.
The Journal of biological chemistry 2002;277(22):19353-7.
2002: Ikuyo Kusaka; Takako Saito; Tomoatsu Nakamura; Shoichiro Nagasaka; Shun Ishibashi; San-e Ishikawa
Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis.
Nephron 2002;91(1):167-9.
2002: Tomohiro Yoshikawa; Hitoshi Shimano; Naoya Yahagi; Tomohiro Ide; Michiyo Amemiya-Kudo; Takashi Matsuzaka; Masanori Nakakuki; Sachiko Tomita; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Akimitsu Takahashi; Hirohito Sone; Jun-ichi Osuga Ji; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements.
The Journal of biological chemistry 2002;277(3):1705-11.
2002: Takashi Matsuzaka; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Tomohiro Yoshikawa; Alyssa H Hasty; Yoshiaki Tamura; Jun-ichi Osuga; Hiroaki Okazaki; Yoko Iizuka; Akimitsu Takahashi; Hirohito Sone; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha.
Journal of lipid research 2002;43(1):107-14.
2001: Alyssa H Hasty; Hitoshi Shimano; Jun-ichi Osuga; I Namatame; Akimitsu Takahashi; Naoya Yahagi; S Perrey; Yoko Iizuka; Yoshiaki Tamura; Michiyo Amemiya-Kudo; Tomohiro Yoshikawa; Hiroaki Okazaki; Ken Ohashi; Kenji Harada; Takashi Matsuzaka; Hirohito Sone; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.
The Journal of biological chemistry 2001;276(40):37402-8.
2001: Tomohiro Yoshikawa; Hitoshi Shimano; Z Chen; Shun Ishibashi; Nobuhiro Yamada
Effects of probucol on atherosclerosis of apoE-deficient or LDL receptor-deficient mice.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2001;33(8):472-9.
2001: Tomohiro Yoshikawa; Hitoshi Shimano; Michiyo Amemiya-Kudo; Naoya Yahagi; Alyssa H Hasty; Takashi Matsuzaka; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter.
Molecular and cellular biology 2001;21(9):2991-3000.
2001: Ryuichi Tozawa; Shun Ishibashi; Jun-ichi Osuga; Kazuhiko Yamamoto; Hiroaki Yagyu; Ken Ohashi; Yoshiaki Tamura; Naoya Yahagi; Yoko Iizuka; Hiroaki Okazaki; Kenji Harada; Takanari Gotoda; Hitoshi Shimano; Satoshi Kimura; Ryozo Nagai; Nobuhiro Yamada
Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit. Its obligate requirement for the stable expression of oligomeric receptor.
The Journal of biological chemistry 2001;276(16):12624-8.
2001: Naoya Yahagi; Shun Ishibashi; Hitoshi Shimano
[Gene therapy for hyperlipoproteinemia].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():715-21.
2001: M Sekiya; Shun Ishibashi
[Helsinki Heart Study].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 3():404-9.
2001: Z Chen; Shun Ishibashi; S Perrey; Takanari Gotoda; Tetsuya Kitamine; Yoshiaki Tamura; Hiroaki Okazaki; Naoya Yahagi; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Kenji Harada; Hitoshi Shimano; Ryozo Nagai; Nobuhiro Yamada
Troglitazone inhibits atherosclerosis in apolipoprotein E-knockout mice: pleiotropic effects on CD36 expression and HDL.
Arteriosclerosis, thrombosis, and vascular biology 2001;21(3):372-7.
2001: S Tomita; Shun Ishibashi
[Lipoprotein(a) [Lp(a)]].
Nihon rinsho. Japanese journal of clinical medicine 2001;59 Suppl 2():86-90.
2001: S Perrey; Shun Ishibashi; Naoya Yahagi; Jun-ichi Osuga; Ryuichi Tozawa; Hiroaki Yagyu; Ken Ohashi; Takanari Gotoda; Kenji Harada; Z Chen; Yoko Iizuka; Futoshi Shionoiri; Nobuhiro Yamada
Thiazolidinedione- and tumor necrosis factor alpha-induced downregulation of peroxisome proliferator-activated receptor gamma mRNA in differentiated 3T3-L1 adipocytes.
Metabolism: clinical and experimental 2001;50(1):36-40.
2001: S Perrey; Shun Ishibashi; Tetsuya Kitamine; Jun-ichi Osuga; Hiroaki Yagyu; Z Chen; Futoshi Shionoiri; Yoko Iizuka; Naoya Yahagi; Yoshiaki Tamura; Ken Ohashi; Kenji Harada; Takanari Gotoda; Nobuhiro Yamada
The LDL receptor is the major pathway for beta-VLDL uptake by mouse peritoneal macrophages.
Atherosclerosis 2001;154(1):51-60.
2000: Michiyo Amemiya-Kudo; Hitoshi Shimano; Tomohiro Yoshikawa; Naoya Yahagi; Alyssa H Hasty; Hiroaki Okazaki; Yoshiaki Tamura; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryuichiro Sato; Satoshi Kimura; Shun Ishibashi; Nobuhiro Yamada
Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene.
The Journal of biological chemistry 2000;275(40):31078-85.
2000: Alyssa H Hasty; Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; S Perrey; Tomohiro Yoshikawa; Jun-ichi Osuga; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level.
The Journal of biological chemistry 2000;275(40):31069-77.
2000: Ken Ohashi; Shun Ishibashi; Jun-ichi Osuga; Ryuichi Tozawa; Kenji Harada; Naoya Yahagi; Futoshi Shionoiri; Yoko Iizuka; Yoshiaki Tamura; Ryozo Nagai; D R Illingworth; Takanari Gotoda; Nobuhiro Yamada
Novel mutations in the microsomal triglyceride transfer protein gene causing abetalipoproteinemia.
Journal of lipid research 2000;41(8):1199-204.
2000: Hiroaki Yagyu; Tetsuya Kitamine; Jun-ichi Osuga; Ryuichi Tozawa; Z Chen; Y Kaji; Toru Oka; S Perrey; Yoshiaki Tamura; Ken Ohashi; Hiroaki Okazaki; Naoya Yahagi; Futoshi Shionoiri; Yoko Iizuka; Kenji Harada; Hitoshi Shimano; H Yamashita; Takanari Gotoda; Nobuhiro Yamada; Shun Ishibashi
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia.
The Journal of biological chemistry 2000;275(28):21324-30.
2000: Jun-ichi Osuga; Shun Ishibashi; Toru Oka; Hiroaki Yagyu; Ryuichi Tozawa; A Fujimoto; Futoshi Shionoiri; Naoya Yahagi; Fredric B Kraemer; O Tsutsumi; Nobuhiro Yamada
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):787-92.
2000: T Yoshida; Takanari Gotoda; M Okubo; Yoko Iizuka; Shun Ishibashi; T Kojima; Takeshi Murakami; T Murase; Nobuhiro Yamada
A Japanese patient with lipoprotein lipase deficiency homozygous for the Gly188Glu mutation prevalent worldwide.
Journal of atherosclerosis and thrombosis 2000;7(1):45-9.
2000: Shun Ishibashi
[LDL receptor].
Nihon rinsho. Japanese journal of clinical medicine 2000;58 Suppl 1():535-9.
1999: Naoya Yahagi; Hitoshi Shimano; Alyssa H Hasty; Michiyo Amemiya-Kudo; Hiroaki Okazaki; Yoshiaki Tamura; Yoko Iizuka; Futoshi Shionoiri; Ken Ohashi; Jun-ichi Osuga; Kenji Harada; Takanari Gotoda; Ryozo Nagai; Shun Ishibashi; Nobuhiro Yamada
A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.
The Journal of biological chemistry 1999;274(50):35840-4.
1999: Hitoshi Shimano; Naoya Yahagi; Michiyo Amemiya-Kudo; Alyssa H Hasty; Jun-ichi Osuga; Yoshiaki Tamura; Futoshi Shionoiri; Yoko Iizuka; Ken Ohashi; Kenji Harada; Takanari Gotoda; Shun Ishibashi; Nobuhiro Yamada
Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.
The Journal of biological chemistry 1999;274(50):35832-9.
1999: Shun Ishibashi
[Gene therapy of hyperlipoproteinemia].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(12):2862-8.
1999: Ryuichi Tozawa; Shun Ishibashi; Jun-ichi Osuga; Hiroaki Yagyu; Toru Oka; Z Chen; Ken Ohashi; S Perrey; Futoshi Shionoiri; Naoya Yahagi; Kenji Harada; Takanari Gotoda; Yoshio Yazaki; Nobuhiro Yamada
Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.
The Journal of biological chemistry 1999;274(43):30843-8.
1999: Hiroaki Yagyu; Shun Ishibashi; Z Chen; Jun-ichi Osuga; Mitsuyo Okazaki; S Perrey; Tetsuya Kitamine; M Shimada; Ken Ohashi; Kenji Harada; Futoshi Shionoiri; Naoya Yahagi; Takanari Gotoda; Yoshio Yazaki; Nobuhiro Yamada
Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice.
Journal of lipid research 1999;40(9):1677-85.
1998: Ken Ohashi; Shun Ishibashi; Masayuki Yamamoto; Jun-ichi Osuga; Yoshio Yazaki; S Yukawa; Nobuhiro Yamada
A truncated species of apolipoprotein B (B-38.7) in a patient with homozygous hypobetalipoproteinemia associated with diabetes mellitus.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(8):1330-4.
1998: Jun-ichi Osuga; M Yonemoto; Nobuhiro Yamada; Hitoshi Shimano; Hiroaki Yagyu; Ken Ohashi; Kenji Harada; T Kamei; Yoshio Yazaki; Shun Ishibashi
Cholesterol lowering in low density lipoprotein receptor knockout mice overexpressing apolipoprotein E.
The Journal of clinical investigation 1998;102(2):386-94.
1998: L Sun; Shun Ishibashi; Jun-ichi Osuga; Kenji Harada; Ken Ohashi; Takanari Gotoda; Y Fukuo; Yoshio Yazaki; Nobuhiro Yamada
Clinical features associated with the homozygous Trp64Arg mutation of the beta3-adrenergic receptor: no evidence for its association with obesity in Japanese.
Arteriosclerosis, thrombosis, and vascular biology 1998;18(6):941-6.
1998: H Abe; Nobuhiro Yamada; K Kamata; T Kuwaki; M Shimada; Jun-ichi Osuga; Futoshi Shionoiri; Naoya Yahagi; Takashi Kadowaki; H Tamemoto; Shun Ishibashi; Yoshio Yazaki; M Makuuchi
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
The Journal of clinical investigation 1998;101(8):1784-8.
1997: Kenji Harada; Z Chen; Shun Ishibashi; Jun-ichi Osuga; Hiroaki Yagyu; Ken Ohashi; Naoya Yahagi; Futoshi Shionoiri; L Sun; Yoshio Yazaki; Nobuhiro Yamada
Apoptotic cell death in atherosclerotic plaques of hyperlipidemic knockout mice.
Atherosclerosis 1997;135(2):235-9.
1997: Shun Ishibashi
[Apolipoprotein genes].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl():490-7.
1997: Jun-ichi Osuga; H Yagyu; Ken Ohashi; Kenji Harada; Yoshio Yazaki; Nobuhiro Yamada; Shun Ishibashi
Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1.
Biochemical and biophysical research communications 1997;236(2):375-8.
1997: Kenji Harada; Shun Ishibashi; T Miyashita; Jun-ichi Osuga; H Yagyu; Ken Ohashi; Yoshio Yazaki; Nobuhiro Yamada
Bcl-2 protein inhibits oxysterol-induced apoptosis through suppressing CPP32-mediated pathway.
FEBS letters 1997;411(1):63-6.
1997: Takanari Gotoda; M Kinoshita; Shun Ishibashi; T Inaba; Kenji Harada; M Shimada; Jun-ichi Osuga; T Teramoto; Yoshio Yazaki; Nobuhiro Yamada
Skipping of exon 14 and possible instability of both the mRNA and the resultant truncated protein underlie a common cholesteryl ester transfer protein deficiency in Japan.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1376-81.
1997: Jun-ichi Osuga; Shun Ishibashi; Hitoshi Shimano; T Inaba; M Kawamura; Yoshio Yazaki; Nobuhiro Yamada
Suppression of neutral cholesterol ester hydrolase activity by antisense DNA of hormone-sensitive lipase.
Biochemical and biophysical research communications 1997;233(3):655-7.
1997: Shun Ishibashi
[LDL receptor].
Nihon rinsho. Japanese journal of clinical medicine 1997;55 Suppl 2():577-80.
1996: T Inaba; Shun Ishibashi; K Harada; Jun-ichi Osuga; Hiroaki Yagyu; Ken Ohashi; Y Yazaki; Nobuhiro Yamada
Synergistic effects of transforming growth factor-beta on the expression of c-fms, macrophage colony-stimulating factor receptor gene, in vascular smooth muscle cells.
FEBS letters 1996;399(3):207-10.
1996: T Inaba; Shun Ishibashi; K Harada; J Ohsuga; Ken Ohashi; Hiroaki Yagyu; Y Yazaki; S Higashiyama; S Kawata; Yuji Matsuzawa; Nobuhiro Yamada
Induction of macrophage colony-stimulating factor receptor (c-fms) expression in vascular medial smooth muscle cells treated with heparin binding epidermal growth factor-like growth factor.
The Journal of biological chemistry 1996;271(40):24413-7.
1996: Shun Ishibashi; S Perrey; Z Chen; Jun-ichi Osuga; Mitsuo Shimada; Ken Ohashi; K Harada; Y Yazaki; Nobuhiro Yamada
Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both.
The Journal of biological chemistry 1996;271(37):22422-7.
1996: Mitsuo Shimada; Shun Ishibashi; T Inaba; Hiroaki Yagyu; K Harada; Jun-ichi Osuga; Ken Ohashi; Y Yazaki; Nobuhiro Yamada
Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(14):7242-6.
1996: K Harada; Hitoshi Shimano; Shun Ishibashi; Nobuhiro Yamada
Transgenic mouse and gene therapy.
Diabetes 1996;45 Suppl 3():S129-32.
1996: T Inaba; Takanari Gotoda; Shun Ishibashi; K Harada; J I Ohsuga; Ken Ohashi; Y Yazaki; Nobuhiro Yamada
Transcription factor PU.1 mediates induction of c-fms in vascular smooth muscle cells: a mechanism for phenotypic change to phagocytic cells.
Molecular and cellular biology 1996;16(5):2264-73.
1996: T Inaba; Shun Ishibashi; Takanari Gotoda; M Kawamura; N Morino; Yoshihisa Nojima; M Kawakami; Y Yazaki; Nobuhiro Yamada
Enhanced expression of platelet-derived growth factor-beta receptor by high glucose. Involvement of platelet-derived growth factor in diabetic angiopathy.
Diabetes 1996;45(4):507-12.
1995: Mitsuo Shimada; Shun Ishibashi; Takanari Gotoda; M Kawamura; K Yamamoto; T Inaba; K Harada; J Ohsuga; S Perrey; Y Yazaki
Overexpression of human lipoprotein lipase protects diabetic transgenic mice from diabetic hypertriglyceridemia and hypercholesterolemia.
Arteriosclerosis, thrombosis, and vascular biology 1995;15(10):1688-94.
1995: Jun-ichi Osuga; T Inaba; K Harada; Hiroaki Yagyu; Mitsuo Shimada; Y Yazaki; Nobuhiro Yamada; Shun Ishibashi
Cloning and structural analysis of the mouse apolipoprotein B mRNA editing protein gene.
Biochemical and biophysical research communications 1995;214(2):653-62.
1995: Mitsuo Shimada; Shun Ishibashi; K Yamamoto; M Kawamura; Y Watanabe; Takanari Gotoda; K Harada; T Inaba; J Ohsuga; Y Yazaki
Overexpression of human lipoprotein lipase increases hormone-sensitive lipase activity in adipose tissue of mice.
Biochemical and biophysical research communications 1995;211(3):761-6.
1995: T Inaba; Takanari Gotoda; K Harada; Mitsuo Shimada; J Ohsuga; Shun Ishibashi; Y Yazaki; Nobuhiro Yamada
Induction of sustained expression of proto-oncogene c-fms by platelet-derived growth factor, epidermal growth factor, and basic fibroblast growth factor, and its suppression by interferon-gamma and macrophage colony-stimulating factor in human aortic medial smooth muscle cells.
The Journal of clinical investigation 1995;95(3):1133-9.
1994: Shun Ishibashi; Nobuhiro Yamada
[Perspective of gene therapy in hyperlipoproteinemia].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(12):3303-8.
1994: Shun Ishibashi
[LDL-receptor-related protein].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(12):3177-83.
1993: Shun Ishibashi; N Mori; Mitsuo Shimada; T Oka; Hitoshi Shimano; Takanari Gotoda; Kajuro Komeda; Shoji Kawazu; T Murase; Y Yazaki
Apolipoprotein E metabolism in sciatic nerves of diabetic rats. Implication for diabetic neuropathy.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1993;25(2):82-7.
1992: Nobuhiro Yamada; Shun Ishibashi; Hitoshi Shimano; T Inaba; Takanari Gotoda; K Harada; Mitsuo Shimada; M Shiomi; Y Watanabe; M Kawakami
Role of monocyte colony-stimulating factor in foam cell generation.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 1992;200(2):240-4.
1991: Takanari Gotoda; Nobuhiro Yamada; T Murase; T Inaba; Shun Ishibashi; Hitoshi Shimano; S Koga; Y Yazaki; Yasuhiro Furuichi; F Takaku
Occurrence of multiple aberrantly spliced mRNAs upon a donor splice site mutation that causes familial lipoprotein lipase deficiency.
The Journal of biological chemistry 1991;266(36):24757-62.
1991: Takanari Gotoda; Nobuhiro Yamada; M Kawamura; K Kozaki; N Mori; Shun Ishibashi; Hitoshi Shimano; F Takaku; Y Yazaki; Yasuhiro Furuichi
Heterogeneous mutations in the human lipoprotein lipase gene in patients with familial lipoprotein lipase deficiency.
The Journal of clinical investigation 1991;88(6):1856-64.
1991: N Mori; Takanari Gotoda; Shun Ishibashi; Hitoshi Shimano; K Harada; T Inaba; F Takaku; Y Yazaki; Nobuhiro Yamada
Effects of human recombinant macrophage colony-stimulating factor on the secretion of lipoprotein lipase from macrophages.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(5):1315-21.
1991: I Inoue; Shun Ishibashi; K Harada; Hitoshi Shimano; Takanari Gotoda; Mitsuo Shimada; K Takahashi; J Ishii; Y Yazaki; Nobuhiro Yamada
Overexpression of low density lipoprotein receptor on Chinese hamster ovary cells generates foam cells.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1991;11(5):1310-4.
1991: Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi; H Mokuno; N Mori; Takanari Gotoda; K Harada; Yasuo Akanuma; T Murase; Y Yazaki
Oxidation-labile subfraction of human plasma low density lipoprotein isolated by ion-exchange chromatography.
Journal of lipid research 1991;32(5):763-73.
1991: H Mokuno; Nobuhiro Yamada; Hitoshi Shimano; Shun Ishibashi; N Mori; K Takahashi; T Oka; T H Yoon; F Takaku
The enhanced cellular uptake of very-low-density lipoprotein enriched in apolipoprotein E.
Biochimica et biophysica acta 1991;1082(1):63-70.
1991: T H Yoon; N Mori; K Kitamura; Shun Ishibashi; Hitoshi Shimano; H Mokuno; Takanari Gotoda; F Takaku; Nobuhiro Yamada
Characterization of monoclonal anti-rabbit apolipoprotein E antibodies and chemical composition of lipoproteins separated by anti-apolipoprotein E immuno-affinity chromatography.
Journal of biochemistry 1991;109(2):204-10.
1990: K Harada; Hitoshi Shimano; M Kawakami; Shun Ishibashi; Takanari Gotoda; N Mori; F Takaku; Nobuhiro Yamada
Effect of tumor necrosis factor/cachectin on the activity of the low density lipoprotein receptor on human skin fibroblasts.
Biochemical and biophysical research communications 1990;172(3):1022-7.
1990: Shun Ishibashi; T Inaba; Hitoshi Shimano; K Harada; I Inoue; H Mokuno; N Mori; Takanari Gotoda; F Takaku; Nobuhiro Yamada
Monocyte colony-stimulating factor enhances uptake and degradation of acetylated low density lipoproteins and cholesterol esterification in human monocyte-derived macrophages.
The Journal of biological chemistry 1990;265(24):14109-17.
1990: Hitoshi Shimano; Nobuhiro Yamada; Shun Ishibashi; K Harada; A Matsumoto; N Mori; T Inaba; K Motoyoshi; H Itakura; F Takaku
Human monocyte colony-stimulating factor enhances the clearance of lipoproteins containing apolipoprotein B-100 via both low density lipoprotein receptor-dependent and -independent pathways in rabbits.
The Journal of biological chemistry 1990;265(22):12869-75.
1990: H Mokuno; Nobuhiro Yamada; T Sugimoto; T Kobayashi; Shun Ishibashi; Hitoshi Shimano; M Takizawa; M Kawakami; F Takaku; T Murase
Cholesterol-free diet with a high ratio of polyunsaturated to saturated fatty acids in heterozygous familial hypercholesterolemia: significant lowering effect on plasma cholesterol.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1990;22(4):246-51.
1990: Shun Ishibashi; Nobuhiro Yamada; Hitoshi Shimano; N Mori; H Mokuno; T Gotohda; M Kawakami; T Murase; F Takaku
Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake.
The Journal of biological chemistry 1990;265(6):3040-7.
1990: H Mokuno; Shun Ishibashi; Hitoshi Shimano; T Gothoda; F Takaku; Nobuhiro Yamada
Effect of exogenous apo E on the cellular binding of lipoproteins.
Gerontology 1990;36 Suppl 1():42-8.
1990: Hitoshi Shimano; Nobuhiro Yamada; K Motoyoshi; A Matsumoto; Shun Ishibashi; N Mori; F Takaku
Plasma cholesterol-lowering activity of monocyte colony-stimulating factor (M-CSF).
Annals of the New York Academy of Sciences 1990;587():362-70.
1989: Hitoshi Shimano; Shun Ishibashi; T Murase; T Gotohda; Nobuhiro Yamada; F Takaku; E Ohtomo
Plasma apolipoproteins in patients with multi-infarct dementia.
Atherosclerosis 1989;79(2-3):257-60.
1989: Shun Ishibashi; N Mori; T Murase; Hitoshi Shimano; T Gotohda; M Kawakami; Yasuo Akanuma; F Takaku; Nobuhiro Yamada
Enhanced lipoprotein lipase secretion from human monocyte-derived macrophages caused by hypertriglyceridemic very low density lipoproteins.
Arteriosclerosis (Dallas, Tex.) 1989;9(5):650-5.
1989: Shun Ishibashi; Nobuhiro Yamada; Hitoshi Shimano; F Takaku; Yasuo Akanuma; T Murase
Composition of very-low-density lipoproteins in non-insulin-dependent diabetes mellitus.
Clinical chemistry 1989;35(5):808-12.
1989: Nobuhiro Yamada; Hitoshi Shimano; H Mokuno; Shun Ishibashi; T Gotohda; M Kawakami; Y Watanabe; Yasuo Akanuma; T Murase; F Takaku
Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(2):665-9.
1988: Hitoshi Shimano; Hiroyuki Aburatani; N Mori; Shun Ishibashi; T Gotohda; H Mokuno; M Kawakami; Yasuo Akanuma; F Takaku; T Murase
Down-regulation of hepatic LDL receptor protein and messenger RNA in fasted rabbits.
Journal of biochemistry 1988;104(5):712-6.
1988: Shun Ishibashi; Nobuhiro Yamada; Yoshitaka Oka; Hitoshi Shimano; N Mori; T H Yoon; Mitsuo Shimada; Y Kanazawa; Yasuo Akanuma; T Murase
Enhanced synthesis and secretion of apolipoprotein E from sciatic nerves of streptozotocin-induced diabetic rats after injury.
Biochemical and biophysical research communications 1988;155(1):283-8.
1987: N Mori; Nobuhiro Yamada; Shun Ishibashi; M Kawakami; K Takahashi; Hitoshi Shimano; M Fujisawa; F Takaku; T Murase
High-cholesterol diet-induced lipoproteins stimulate lipoprotein lipase secretion in cultured rat alveolar macrophages.
Biochimica et biophysica acta 1987;922(2):103-10.