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Joseph Avruch

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Laura Regué; Fan Mou; Joseph Avruch
G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene.
Ning Dai; Finn C Nielsen; Jan Christiansen; Joseph Avruch
mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.
Joseph Avruch; Nabeel Bardeesy; Julien Fitamant; Fan Mou; Dawang Zhou; Laura Regué Barrufet
Protein kinases of the Hippo pathway: regulation and substrates.

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2013: Laura Regué; Fan Mou; Joseph Avruch
G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene.
BioEssays : news and reviews in molecular, cellular and developmental biology 2013;35(5):430-5.
2013: Ning Dai; Finn C Nielsen; Jan Christiansen; Joseph Avruch
mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.
Genes & development 2013;27(3):301-12.
2012: Joseph Avruch; Nabeel Bardeesy; Julien Fitamant; Fan Mou; Dawang Zhou; Laura Regué Barrufet
Protein kinases of the Hippo pathway: regulation and substrates.
Seminars in cell & developmental biology 2012;23(7):770-84.
2012: Fan Mou; Maria Praskova; Denille Van Buren; Fan Xia; Joseph Avruch; Hanno Hock; Dawang Zhou
The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.
The Journal of experimental medicine 2012;209(4):741-59.
2012: John M Kyriakis; Joseph Avruch
Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.
Physiological reviews 2012;92(2):689-737.
2012: Lanfen Chen; Xianming Deng; Funiu Qin; Joseph Avruch; Dawang Zhou
Hippo pathway in intestinal homeostasis and tumorigenesis.
Protein & cell 2012;3(4):305-10.
2012: Joseph Avruch; Dawang Zhou; Nabeel Bardeesy
YAP oncogene overexpression supercharges colon cancer proliferation.
Cell cycle (Georgetown, Tex.) 2012;11(6):1090-6.
2012: Denise L Faustman; Guotong Man; Joseph Avruch; Liqin Ban; Douglas Burger; Yoshiaki Okubo; Richard Pompei; David Schoenfeld; Limei Wang; Hui Zheng; David M Nathan
Proof-of-concept, randomized, controlled clinical trial of Bacillus-Calmette-Guerin for treatment of long-term type 1 diabetes.
PloS one 2012;7(8):e41756.
2012: Angela Papageorgiou; Joseph Avruch
A genome-wide RNAi screen for polypeptides that alter rpS6 phosphorylation.
Methods in molecular biology (Clifton, N.J.) 2012;821():187-214.
2011: Dawang Zhou; Evan Barry; Fernando D Camargo; Dawn Dawson; Earl Lawrence; Sanford D Markowitz; Joseph E Willis; Hongtan Wu; Yi Yin; Yongyou Zhang; Joseph Avruch
Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(49):E1312-20.
2011: Joseph Rapley; Sara Ortiz-Vega; Noriko Oshiro; Joseph Avruch
The mechanism of insulin-stimulated 4E-BP protein binding to mammalian target of rapamycin (mTOR) complex 1 and its contribution to mTOR complex 1 signaling.
The Journal of biological chemistry 2011;286(44):38043-53.
2011: M Teresa Bertran; Carme Caelles; Laura Regué; Joseph Avruch; Sara Sdelci; Joan Roig
Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5.
The EMBO journal 2011;30(13):2634-47.
2011: Ning Dai; Joseph Rapley; Matthew Angel; M Fatih Yanik; Michael D Blower; Joseph Avruch
mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.
Genes & development 2011;25(11):1159-72.
2011: Karin Schlegelmilch; Morvarid Mohseni; Oktay Kirak; Jan Pruszak; J Renato Rodriguez; Dawang Zhou; Bridget T Kreger; Valera Vasioukhin; Joseph Avruch; Thijn R Brummelkamp; Fernando D Camargo
Yap1 acts downstream of α-catenin to control epidermal proliferation.
Cell 2011;144(5):782-95.
2010: Jikyoung Park; Soo Im Kang; Sun-Young Lee; Xian F Zhang; Myoung Shin Kim; Lisa F Beers; Dae-Sik Lim; Joseph Avruch; Ho-Shik Kim; Sean Bong Lee
Tumor suppressor ras association domain family 5 (RASSF5/NORE1) mediates death receptor ligand-induced apoptosis.
The Journal of biological chemistry 2010;285(45):35029-38.
2009: Dawang Zhou; Claudius Conrad; Fan Xia; Ji-Sun Park; Bernhard Payer; Yi Yin; Gregory Y Lauwers; Wolfgang Thasler; Jeannie T Lee; Joseph Avruch; Nabeel Bardeesy
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.
Cancer cell 2009;16(5):425-38.
2009: Yenshou Lin; Joseph Avruch
pTOM, a vector for expressing two proteins in mammalian cells.
Analytical biochemistry 2009;388(2):353-5.
2009: Joseph Avruch; Ramnik Xavier; Nabeel Bardeesy; Xian-Feng Zhang; Maria Praskova; Dawang Zhou; Fan Xia
Rassf family of tumor suppressor polypeptides.
The Journal of biological chemistry 2009;284(17):11001-5.
2009: Joseph Avruch; Xiaomeng Long; Sara Ortiz-Vega; Joseph Rapley; Angela Papageorgiou; Ning Dai
Amino acid regulation of TOR complex 1.
American journal of physiology. Endocrinology and metabolism 2009;296(4):E592-602.
2009: Joseph Avruch; Xiaomeng Long; Yenshou Lin; Sara Ortiz-Vega; Joseph Rapley; Angela Papageorgiou; Noriko Oshiro; Ushio Kikkawa
Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor.
Biochemical Society transactions 2009;37(Pt 1):223-6.
2009: Ilona Patursky-Polischuk; Miri Stolovich-Rain; Mirit Hausner-Hanochi; Judith Kasir; Nadine Cybulski; Joseph Avruch; Markus A Rüegg; Michael N Hall; Oded Meyuhas
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.
Molecular and cellular biology 2009;29(3):640-9.
2008: Dawang Zhou; Benjamin D Medoff; Lanfen Chen; Lequn Li; Xian-feng Zhang; Maria Praskova; Matthew Liu; Aimee Landry; Richard S Blumberg; Vassiliki A Boussiotis; Ramnik Xavier; Joseph Avruch
The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(51):20321-6.
2008: Joseph Rapley; Marta Nicolàs; Aaron Groen; Laura Regué; M Teresa Bertran; Carme Caelles; Joseph Avruch; Joan Roig
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation.
Journal of cell science 2008;121(Pt 23):3912-21.
2008: Montserrat C Anguera; Matthew Liu; Joseph Avruch; Jeannie T Lee
Characterization of two Mst1-deficient mouse models.
Developmental dynamics : an official publication of the American Association of Anatomists 2008;237(11):3424-34.
2008: G Nana Hagan; Yenshou Lin; Mark Magnuson; Joseph Avruch; Michael P Czech
A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Molecular and cellular biology 2008;28(13):4215-26.
2008: Maria Praskova; Fan Xia; Joseph Avruch
MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.
Current biology : CB 2008;18(5):311-21.
2007: Joseph Avruch
MAP kinase pathways: the first twenty years.
Biochimica et biophysica acta 2007;1773(8):1150-60.
2007: Noriko Oshiro; Rinako Takahashi; Ken-ichi Yoshino; Keiko Tanimura; Akio Nakashima; Satoshi Eguchi; Takafumi Miyamoto; Kenta Hara; Kenji Takehana; Joseph Avruch; Ushio Kikkawa; Kazuyoshi Yonezawa
The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1.
The Journal of biological chemistry 2007;282(28):20329-39.
2007: Xiaomeng Long; Yenshou Lin; Sara Ortiz-Vega; Susann Busch; Joseph Avruch
The Rheb switch 2 segment is critical for signaling to target of rapamycin complex 1.
The Journal of biological chemistry 2007;282(25):18542-51.
2006: Joseph Avruch; K Hara; Y Lin; M Liu; X Long; Sara Ortiz-Vega; K Yonezawa
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase.
Oncogene 2006;25(48):6361-72.
2006: Kazuhiro Ishiguro; Joseph Avruch; Aimee Landry; Shan Qin; Takafumi Ando; Hidemi Goto; Ramnik Xavier
Nore1B regulates TCR signaling via Ras and Carma1.
Cellular signalling 2006;18(10):1647-54.
2006: Joseph Avruch; Maria Praskova; Sara Ortiz-Vega; Matthew Liu; Xian-Feng Zhang
Nore1 and RASSF1 regulation of cell proliferation and of the MST1/2 kinases.
Methods in enzymology 2006;407():290-310.
2005: Guido Lenz; Joseph Avruch
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
The Journal of biological chemistry 2005;280(46):38121-4.
2005: Jun Zhu; Vitaly Balan; Agnieszka Bronisz; Karina Balan; Hengrui Sun; Deborah T Leicht; Zhijun Luo; Jun Qin; Joseph Avruch; Guri Tzivion
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding.
Molecular biology of the cell 2005;16(10):4733-44.
2005: Joan Roig; Aaron Groen; Jennifer Caldwell; Joseph Avruch
Active Nercc1 protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly.
Molecular biology of the cell 2005;16(10):4827-40.
2005: Xiaomeng Long; Sara Ortiz-Vega; Yenshou Lin; Joseph Avruch
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.
The Journal of biological chemistry 2005;280(25):23433-6.
2005: Xiaomeng Long; Yenshou Lin; Sara Ortiz-Vega; Kazuyoshi Yonezawa; Joseph Avruch
Rheb binds and regulates the mTOR kinase.
Current biology : CB 2005;15(8):702-13.
2005: Joseph Avruch; Yenshou Lin; Xiaomeng Long; Sid Murthy; Sara Ortiz-Vega
Recent advances in the regulation of the TOR pathway by insulin and nutrients.
Current opinion in clinical nutrition and metabolic care 2005;8(1):67-72.
2004: Maria Praskova; Andrei Khoklatchev; Sara Ortiz-Vega; Joseph Avruch
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras.
The Biochemical journal 2004;381(Pt 2):453-62.
2004: Shahrooz Rabizadeh; Ramnik Xavier; Kazuhiro Ishiguro; Juliocesar Bernabeortiz; Marco Lopez-Ilasaca; Andrei Khokhlatchev; Pamela Mollahan; Gerd P Pfeifer; Joseph Avruch; Brian Seed
The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death.
The Journal of biological chemistry 2004;279(28):29247-54.
2004: Yumi Aoyama; Joseph Avruch; Xian-Feng Zhang
Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinases.
Oncogene 2004;23(19):3426-33.
2004: Noriko Oshiro; Ken-ichi Yoshino; Sujuti Hidayat; Chiharu Tokunaga; Kenta Hara; Satoshi Eguchi; Joseph Avruch; Kazuyoshi Yonezawa
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function.
Genes to cells : devoted to molecular & cellular mechanisms 2004;9(4):359-66.
2003: Ying H Shen; Jakub Godlewski; Agnieszka Bronisz; Jun Zhu; Michael J Comb; Joseph Avruch; Guri Tzivion
Significance of 14-3-3 self-dimerization for phosphorylation-dependent target binding.
Molecular biology of the cell 2003;14(11):4721-33.
2003: Christopher Belham; Joan Roig; Jennifer A Caldwell; Yumi Aoyama; Bruce E Kemp; Michael J Comb; Joseph Avruch
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
The Journal of biological chemistry 2003;278(37):34897-909.
2003: Hiroki Nojima; Chiharu Tokunaga; Satoshi Eguchi; Noriko Oshiro; Sujuti Hidayat; Ken-ichi Yoshino; Kenta Hara; Noriaki Tanaka; Joseph Avruch; Kazuyoshi Yonezawa
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.
The Journal of biological chemistry 2003;278(18):15461-4.
2002: Yenshou Lin; Andrei Khokhlatchev; Daniel Figeys; Joseph Avruch
Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.
The Journal of biological chemistry 2002;277(50):47991-8001.
2002: Xiaomeng Long; Carmen Spycher; Z Stanley Han; Ann M Rose; Fritz Müller; Joseph Avruch
TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation.
Current biology : CB 2002;12(17):1448-61.
2002: Kenta Hara; Yoshiko Maruki; Xiaomeng Long; Ken-ichi Yoshino; Noriko Oshiro; Sujuti Hidayat; Chiharu Tokunaga; Joseph Avruch; Kazuyoshi Yonezawa
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
Cell 2002;110(2):177-89.
2002: Joan Roig; Alexei Mikhailov; Christopher Belham; Joseph Avruch
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression.
Genes & development 2002;16(13):1640-58.
2002: Stella Tommasi; Reinhard Dammann; Seung-Gi Jin; Xian-feng Zhang; Joseph Avruch; Gerd P Pfeifer
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1.
Oncogene 2002;21(17):2713-20.
2002: Sara Ortiz-Vega; Andrei Khokhlatchev; Maria Nedwidek; Xian-feng Zhang; Reinhard Dammann; Gerd P Pfeifer; Joseph Avruch
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.
Oncogene 2002;21(9):1381-90.
2002: Andrei Khokhlatchev; Shahrooz Rabizadeh; Ramnik Xavier; Maria Nedwidek; Tao Chen; Xian-feng Zhang; Brian Seed; Joseph Avruch
Identification of a novel Ras-regulated proapoptotic pathway.
Current biology : CB 2002;12(4):253-65.
2002: Guri Tzivion; Joseph Avruch
14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.
The Journal of biological chemistry 2002;277(5):3061-4.
2002: Shilan Wu; Alexei Mikhailov; Heidi Kallo-Hosein; Kenta Hara; Kazuyoshi Yonezawa; Joseph Avruch
Characterization of ubiquilin 1, an mTOR-interacting protein.
Biochimica et biophysica acta 2002;1542(1-3):41-56.
2001: Christopher Belham; Michael J Comb; Joseph Avruch
Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase.
Current biology : CB 2001;11(15):1155-67.
2001: Joseph Avruch; Christopher Belham; QP Weng; K Hara; K Yonezawa
The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.
Progress in molecular and subcellular biology 2001;26():115-54.
2001: Joseph Avruch; Andrei Khokhlatchev; John M Kyriakis; Zhijun Luo; Guri Tzivion; D Vavvas; Xian-feng Zhang
Ras activation of the Raf kinase: tyrosine kinase recruitment of the MAP kinase cascade.
Recent progress in hormone research 2001;56():127-55.
2000: Guri Tzivion; Z J Luo; Joseph Avruch
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo.
The Journal of biological chemistry 2000;275(38):29772-8.
2000: K Yokogami; S Wakisaka; Joseph Avruch; Steven A Reeves
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR.
Current biology : CB 2000;10(1):47-50.
1999: A Balendran; R Currie; Christopher G Armstrong; Joseph Avruch; Dario R Alessi
Evidence that 3-phosphoinositide-dependent protein kinase-1 mediates phosphorylation of p70 S6 kinase in vivo at Thr-412 as well as Thr-252.
The Journal of biological chemistry 1999;274(52):37400-6.
1999: Shuji Isotani; Kenta Hara; Chiharu Tokunaga; H Inoue; Joseph Avruch; Kazuyoshi Yonezawa
Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro.
The Journal of biological chemistry 1999;274(48):34493-8.
1999: Christopher Belham; S Wu; Joseph Avruch
Intracellular signalling: PDK1--a kinase at the hub of things.
Current biology : CB 1999;9(3):R93-6.
1999: K Shigemitsu; Y Tsujishita; Kenta Hara; M Nanahoshi; Joseph Avruch; Kazuyoshi Yonezawa
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells.
The Journal of biological chemistry 1999;274(2):1058-65.
1998: K Akimoto; M Nakaya; T Yamanaka; J Tanaka; S Matsuda; QP Weng; Joseph Avruch; Shigeaki Ohno
Atypical protein kinase Clambda binds and regulates p70 S6 kinase.
The Biochemical journal 1998;335 ( Pt 2)():417-24.
1998: Guri Tzivion; Zhijun Luo; Joseph Avruch
A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity.
Nature 1998;394(6688):88-92.
1998: QP Weng; MT Kozlowski; Christopher Belham; Ailiang Zhang; Michael J Comb; Joseph Avruch
Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.
The Journal of biological chemistry 1998;273(26):16621-9.
1998: K Hara; K Yonezawa; QP Weng; MT Kozlowski; Christopher Belham; Joseph Avruch
Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.
The Journal of biological chemistry 1998;273(23):14484-94.
1998: D Vavvas; X Li; Joseph Avruch; X F Zhang
Identification of Nore1 as a potential Ras effector.
The Journal of biological chemistry 1998;273(10):5439-42.
1998: K N Dalby; Nick Morrice; F B Caudwell; Joseph Avruch; Philip Cohen
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK.
The Journal of biological chemistry 1998;273(3):1496-505.
1998: Dario R Alessi; MT Kozlowski; QP Weng; Nick Morrice; Joseph Avruch
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro.
Current biology : CB 1998;8(2):69-81.
1997: K Hara; K Yonezawa; MT Kozlowski; T Sugimoto; K Andrabi; QP Weng; M Kasuga; I Nishimoto; Joseph Avruch
Regulation of eIF-4E BP1 phosphorylation by mTOR.
The Journal of biological chemistry 1997;272(42):26457-63.
1997: David Teng; W L Perry; J K Hogan; ML Baumgard; R Bell; S Berry; T Davis; D Frank; Cynthia Frye; T Hattier; R Hu; Srikanth Jammulapati; T Janecki; A Leavitt; J T Mitchell; R Pero; David Sexton; M Schroeder; P H Su; B Swedlund; John M Kyriakis; Joseph Avruch; PL Bartel; AK Wong; Sean V Tavtigian
Human mitogen-activated protein kinase kinase 4 as a candidate tumor suppressor.
Cancer research 1997;57(19):4177-82.
1997: S i Hirai; M Katoh; M Terada; John M Kyriakis; L I Zon; A Rana; Joseph Avruch; Shigeaki Ohno
MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase.
The Journal of biological chemistry 1997;272(24):15167-73.
1997: A Marti; Z Luo; C Cunningham; Y Ohta; J Hartwig; Thomas P Stossel; John M Kyriakis; Joseph Avruch
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.
The Journal of biological chemistry 1997;272(5):2620-8.
1997: Z Luo; Bruno L Diaz; Mark S Marshall; Joseph Avruch
An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ.
Molecular and cellular biology 1997;17(1):46-53.
1996: John M Kyriakis; Joseph Avruch
Sounding the alarm: protein kinase cascades activated by stress and inflammation.
The Journal of biological chemistry 1996;271(40):24313-6.
1996: Z Luo; Guri Tzivion; P J Belshaw; D Vavvas; M Marshall; Joseph Avruch
Oligomerization activates c-Raf-1 through a Ras-dependent mechanism.
Nature 1996;383(6596):181-5.
1996: A Rana; Kathleen A Gallo; P Godowski; S Hirai; Shigeo Ohno; L Zon; John M Kyriakis; Joseph Avruch
The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.
The Journal of biological chemistry 1996;271(32):19025-8.
1996: Thomas Force; C M Pombo; Joseph Avruch; Joseph V Bonventre; John M Kyriakis
Stress-activated protein kinases in cardiovascular disease.
Circulation research 1996;78(6):947-53.
1995: C M Pombo; John Kehrl; I Sánchez; Paul Katz; Joseph Avruch; L I Zon; James R Woodgett; Thomas Force; John M Kyriakis
Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase.
Nature 1995;377(6551):750-4.
1995: Z J Luo; X F Zhang; U Rapp; Joseph Avruch
Identification of the 14.3.3 zeta domains important for self-association and Raf binding.
The Journal of biological chemistry 1995;270(40):23681-7.
1995: John M Kyriakis; James R Woodgett; Joseph Avruch
The stress-activated protein kinases. A novel ERK subfamily responsive to cellular stress and inflammatory cytokines.
Annals of the New York Academy of Sciences 1995;766():303-19.
1995: QP Weng; K Andrabi; A Klippel; MT Kozlowski; L T Williams; Joseph Avruch
Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(12):5744-8.
1995: QP Weng; K Andrabi; MT Kozlowski; J R Grove; Joseph Avruch
Multiple independent inputs are required for activation of the p70 S6 kinase.
Molecular and cellular biology 1995;15(5):2333-40.
1995: D Barnard; Bruno L Diaz; L Hettich; E Chuang; X F Zhang; Joseph Avruch; M Marshall
Identification of the sites of interaction between c-Raf-1 and Ras-GTP.
Oncogene 1995;10(7):1283-90.
1995: T Dai; EA Rubie; C C Franklin; Andrew Kraft; D A Gillespie; Joseph Avruch; John M Kyriakis; James R Woodgett
Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function.
Oncogene 1995;10(5):849-55.
1995: X F Zhang; Mark S Marshall; Joseph Avruch
Ras-Raf complexes in vitro.
Methods in enzymology 1995;255():323-31.
1994: I Sánchez; R T Hughes; B J Mayer; K Yee; James R Woodgett; Joseph Avruch; John M Kyriakis; L I Zon
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun.
Nature 1994;372(6508):794-8.
1994: C M Pombo; Joseph V Bonventre; Joseph Avruch; James R Woodgett; John M Kyriakis; Thomas Force
The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion.
The Journal of biological chemistry 1994;269(42):26546-51.
1994: E Chuang; D Barnard; L Hettich; X F Zhang; Joseph Avruch; Mark S Marshall
Critical binding and regulatory interactions between Ras and Raf occur through a small, stable N-terminal domain of Raf and specific Ras effector residues.
Molecular and cellular biology 1994;14(8):5318-25.
1994: Joseph Avruch; X F Zhang; John M Kyriakis
Raf meets Ras: completing the framework of a signal transduction pathway.
Trends in biochemical sciences 1994;19(7):279-83.
1994: John M Kyriakis; P Banerjee; E Nikolakaki; T Dai; EA Rubie; M F Ahmad; Joseph Avruch; James R Woodgett
The stress-activated protein kinase subfamily of c-Jun kinases.
Nature 1994;369(6476):156-60.
1994: Thomas Force; Joseph V Bonventre; Gisela Heidecker; U Rapp; Joseph Avruch; John M Kyriakis
Enzymatic characteristics of the c-Raf-1 protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(4):1270-4.
1993: J R Grove; D J Price; P Banerjee; Ashok Balasubramanyam; M F Ahmad; Joseph Avruch
Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase.
Biochemistry 1993;32(30):7727-38.
1993: John M Kyriakis; Thomas Force; U R Rapp; Joseph V Bonventre; Joseph Avruch
Mitogen regulation of c-Raf-1 protein kinase activity toward mitogen-activated protein kinase-kinase.
The Journal of biological chemistry 1993;268(21):16009-19.
1993: X F Zhang; J Settleman; John Kyriakis; E Takeuchi-Suzuki; S J Elledge; Mark S Marshall; J T Bruder; U R Rapp; Joseph Avruch
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1.
Nature 1993;364(6435):308-13.
1993: Y Sasaki; X F Zhang; M Nishiyama; Joseph Avruch; Jack R Wands
Expression and phosphorylation of insulin receptor substrate 1 during rat liver regeneration.
The Journal of biological chemistry 1993;268(6):3805-8.
1992: D J Price; J R Grove; V Calvo; Joseph Avruch; B E Bierer
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase.
Science (New York, N.Y.) 1992;257(5072):973-7.
1992: M Alexander-Bridges; N K Mukhopadhyay; Ulupi S Jhala; M Denaro; X F Kong; Joseph Avruch; J Maller
Growth factor-activated kinases phosphorylate IRE-ABP.
Biochemical Society transactions 1992;20(3):691-3.
1992: John M Kyriakis; H App; X F Zhang; P Banerjee; D L Brautigan; U R Rapp; Joseph Avruch
Raf-1 activates MAP kinase-kinase.
Nature 1992;358(6385):417-21.
1992: N K Mukhopadhyay; D J Price; John M Kyriakis; S Pelech; J Sanghera; Joseph Avruch
An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.
The Journal of biological chemistry 1992;267(5):3325-35.
1991: Denise L Faustman; X P Li; H Y Lin; Y E Fu; G Eisenbarth; Joseph Avruch; J Guo
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes.
Science (New York, N.Y.) 1991;254(5039):1756-61.
1991: J R Grove; P Banerjee; Ashok Balasubramanyam; P J Coffer; D J Price; Joseph Avruch; James R Woodgett
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.
Molecular and cellular biology 1991;11(11):5541-50.
1991: B J Pulverer; John M Kyriakis; Joseph Avruch; E Nikolakaki; James R Woodgett
Phosphorylation of c-jun mediated by MAP kinases.
Nature 1991;353(6345):670-4.
1991: D J Price; N K Mukhopadhyay; Joseph Avruch
Insulin-activated protein kinases phosphorylate a pseudosubstrate synthetic peptide inhibitor of the p70 S6 kinase.
The Journal of biological chemistry 1991;266(25):16281-4.
1991: A Lavoinne; E Erikson; J L Maller; D J Price; Joseph Avruch; Philip Cohen
Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II.
European journal of biochemistry / FEBS 1991;199(3):723-8.
1991: John M Kyriakis; D L Brautigan; T S Ingebritsen; Joseph Avruch
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity.
The Journal of biological chemistry 1991;266(16):10043-6.
1991: Thomas Force; John M Kyriakis; Joseph Avruch; Joseph V Bonventre
Endothelin, vasopressin, and angiotensin II enhance tyrosine phosphorylation by protein kinase C-dependent and -independent pathways in glomerular mesangial cells.
The Journal of biological chemistry 1991;266(10):6650-6.
1990: P Banerjee; M F Ahmad; J R Grove; Carl J Kozlosky; D J Price; Joseph Avruch
Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8550-4.
1990: John M Kyriakis; Joseph Avruch
pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.
The Journal of biological chemistry 1990;265(28):17355-63.
1990: D J Price; J R Gunsalus; Joseph Avruch
Insulin activates a 70-kDa S6 kinase through serine/threonine-specific phosphorylation of the enzyme polypeptide.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(20):7944-8.
1990: John Kyriakis; Joseph Avruch
Insulin, epidermal growth factor and fibroblast growth factor elicit distinct patterns of protein tyrosine phosphorylation in BC3H1 cells.
Biochimica et biophysica acta 1990;1054(1):73-82.
1990: Joseph Avruch; H E Tornqvist; J R Gunsalus; D J Price; John M Kyriakis; E J Yurkow; M F Ahmad; P Banerjee
The role of tyrosine-and serine-threonine-protein phosphorylation in insulin action.
Advances in second messenger and phosphoprotein research 1990;24():295-300.
1989: J R Grove; P J Deutsch; D J Price; Joel F Habener; Joseph Avruch
Plasmids encoding PKI(1-31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells.
The Journal of biological chemistry 1989;264(33):19506-13.
1989: D J Price; R A Nemenoff; Joseph Avruch
Purification of a hepatic S6 kinase from cycloheximide-treated Rats.
The Journal of biological chemistry 1989;264(23):13825-33.
1988: R A Nemenoff; D J Price; M J Mendelsohn; E A Carter; Joseph Avruch
An S6 kinase activated during liver regeneration is related to the insulin-stimulated S6 kinase in H4 hepatoma cells.
The Journal of biological chemistry 1988;263(36):19455-60.
1988: H E Tornqvist; Joseph Avruch
Relationship of site-specific beta subunit tyrosine autophosphorylation to insulin activation of the insulin receptor (tyrosine) protein kinase activity.
The Journal of biological chemistry 1988;263(10):4593-601.
1988: H E Tornqvist; J R Gunsalus; R A Nemenoff; A R Frackelton; M W Pierce; Joseph Avruch
Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells.
The Journal of biological chemistry 1988;263(1):350-9.
1987: J R Grove; D J Price; Howard M Goodman; Joseph Avruch
Recombinant fragment of protein kinase inhibitor blocks cyclic AMP-dependent gene transcription.
Science (New York, N.Y.) 1987;238(4826):530-3.
1987: H E Tornqvist; M W Pierce; A R Frackelton; R A Nemenoff; Joseph Avruch
Identification of insulin receptor tyrosine residues autophosphorylated in vitro.
The Journal of biological chemistry 1987;262(21):10212-9.
1987: M W Pierce; K Coombs; M Young; Joseph Avruch
Control by insulin and insulin-related growth factor 1 of protein synthesis in a cell-free translational system from chick-embryo fibroblasts.
The Biochemical journal 1987;244(1):239-42.
1986: R A Nemenoff; J R Gunsalus; Joseph Avruch
An insulin-stimulated (ribosomal S6) protein kinase from soluble extracts of H4 hepatoma cells.
Archives of biochemistry and biophysics 1986;245(1):196-203.
1986: Y C Kwok; R A Nemenoff; A C Powers; Joseph Avruch
Kinetic properties of the insulin receptor tyrosine protein kinase: activation through an insulin-stimulated tyrosine-specific, intramolecular autophosphorylation.
Archives of biochemistry and biophysics 1986;244(1):102-13.
1984: R A Nemenoff; Y C Kwok; G I Shulman; Perry Blackshear; R Osathanondh; Joseph Avruch
Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor.
The Journal of biological chemistry 1984;259(8):5058-65.
1982: Joseph Avruch; R A Nemenoff; Perry Blackshear; M W Pierce; R Osathanondh
Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation.
The Journal of biological chemistry 1982;257(24):15162-6.
1982: M W Pierce; J L Palmer; H T Keutmann; T A Hall; Joseph Avruch
The insulin-directed phosphorylation site on ATP-citrate lyase is identical with the site phosphorylated by the cAMP-dependent protein kinase in vitro.
The Journal of biological chemistry 1982;257(18):10681-6.
1982: Joseph Avruch; M C Alexander; J L Palmer; M W Pierce; R A Nemenoff; Perry Blackshear; J P Tipper; L A Witters
Role of insulin-stimulated protein phosphorylation in insulin action.
Federation proceedings 1982;41(10):2629-33.
1982: M C Alexander; J L Palmer; R H Pointer; E M Kowaloff; L L Koumjian; Joseph Avruch
Insulin-stimulated phosphorylation of ATP-citrate lyase in isolated hepatocytes. Stoichiometry and relation to the phosphoenzyme intermediate.
The Journal of biological chemistry 1982;257(4):2049-55.
1981: M W Pierce; J L Palmer; H T Keutmann; Joseph Avruch
ATP-citrate lyase. Structure of a tryptic peptide containing the phosphorylation site directed by glucagon and the cAMP-dependent protein kinase.
The Journal of biological chemistry 1981;256(17):8867-70.
1981: M C Alexander; J L Palmer; R H Pointer; L Koumjian; Joseph Avruch
The role of the cyclic AMP-dependent protein kinase in the glucagon-stimulated phosphorylation of ATP-citrate lyase.
Biochimica et biophysica acta 1981;674(1):37-47.