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Ken Ishii

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Etsushi Kuroda; Cevayir Coban; Ken J Ishii
Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.
Takeshi Kondo; Kenta Maruyama; Tatsuya Saitoh; Junya Kobayashi; Kenshi Komatsu; Shizuo Akira; Glen N Barber; Ken J Ishii; Taro Kawai
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Choon Kit Tang; Shizuo Akira; Taiki Aoshi; Cevayir Coban; Benoit H Dessailly; Junichi Ito; Nao Jounai; Kouji Kobiyama; Etsushi Kuroda; Kenji Mizuguchi; Keiichi Ohata; Ken J Ishii
The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.

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All Publications

2013: Etsushi Kuroda; Cevayir Coban; Ken J Ishii
Particulate adjuvant and innate immunity: past achievements, present findings, and future prospects.
International reviews of immunology 2013;32(2):209-20.
2013: Takeshi Kondo; Kenta Maruyama; Tatsuya Saitoh; Junya Kobayashi; Kenshi Komatsu; Shizuo Akira; Glen N Barber; Ken J Ishii; Taro Kawai
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(8):2969-74.
2013: Choon Kit Tang; Shizuo Akira; Taiki Aoshi; Cevayir Coban; Benoit H Dessailly; Junichi Ito; Nao Jounai; Kouji Kobiyama; Etsushi Kuroda; Kenji Mizuguchi; Keiichi Ohata; Ken J Ishii
The chemotherapeutic agent DMXAA as a unique IRF3-dependent type-2 vaccine adjuvant.
PloS one 2013;8(3):e60038.
2012: Kohhei Tetsutani; Ken J Ishii
Adjuvants in influenza vaccines.
Vaccine 2012;30(52):7658-61.
2012: Hong Zhao; Noha H Abdelgelil; Shizuo Akira; Taiki Aoshi; Richard Culleton; Yukiko Fujita; Toshihiro Horii; Megumi Inoue; Ken J Ishii; Sawako Itagaki; Osamu Kaneko; Aki Konishi; Atsushi Nakagawa; Hirotaka Narita; Keiichi Ohata; Shintaro Sato; Masanori Yagi; Cevayir Coban
Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.
Cell host & microbe 2012;12(5):705-16.
2012: Masaki Shoji; Masashi Tachibana; Kyoko Tomita; Sayaka Tsuzuki; Shizuo Akira; Ken J Ishii; Kazufumi Katayama; Kenji Kawabata; Fuminori Sakurai; Hiroyuki Mizuguchi
Type-I IFN signaling is required for the induction of antigen-specific CD8(+) T cell responses by adenovirus vector vaccine in the gut-mucosa.
Biochemical and biophysical research communications 2012;425(1):89-93.
2012: Christophe J Desmet; Ken J Ishii
Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination.
Nature reviews. Immunology 2012;12(7):479-91.
2012: Nao Jounai; Kouji Kobiyama; Fumihiko Takeshita; Ken J Ishii
Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination.
Frontiers in cellular and infection microbiology 2012;2():168.
2011: Taiki Aoshi; Kouji Kobiyama; Shohei Koyama; Shizuo Akira; Ken J Ishii
Innate and adaptive immune responses to viral infection and vaccination.
Current opinion in virology 2011;1(4):226-32.
2011: Thomas Marichal; Claire Mesnil; Keiichi Ohata; Catherine Sabatel; Shizuo Akira; Denis Bedoret; Fabrice Bureau; Cevayir Coban; Ken J Ishii; Kouji Kobiyama; Pierre Lekeux; Christophe J Desmet
DNA released from dying host cells mediates aluminum adjuvant activity.
Nature medicine 2011;17(8):996-1002.
2011: Kosuke Fujimoto; Thangaraj Karuppuchamy; Naoki Takemura; Masaki Shimohigoshi; Tomohisa Machida; Yasunari Haseda; Taiki Aoshi; Ken J Ishii; Shizuo Akira; Satoshi Uematsu
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(11):6287-95.
2011: Hirokazu Ezoe; Yukihiro Akeda; Zhenyu Piao; Taiki Aoshi; Shohei Koyama; Takeshi Tanimoto; Ken J Ishii; Kazunori Oishi
Intranasal vaccination with pneumococcal surface protein A plus poly(I:C) protects against secondary pneumococcal pneumonia in mice.
Vaccine 2011;29(9):1754-61.
2011: Nao Jounai; Kouji Kobiyama; Masaaki Shiina; Kazuhiro Ogata; Ken J Ishii; Fumihiko Takeshita
NLRP4 negatively regulates autophagic processes through an association with beclin1.
Journal of immunology (Baltimore, Md. : 1950) 2011;186(3):1646-55.
2011: Fadile Yildiz Zeyrek; Fehmi Yuksel; Nobuko Arisue; Yukiko Fujita; Kaori Honjo; Toshihiro Horii; Ken J Ishii; Nirianne Palacpac; Satoru Takeo; Kazuyuki Tanabe; Takafumi Tsuboi; Masanori Yagi; Cevayir Coban
Serologic markers in relation to parasite exposure history help to estimate transmission dynamics of Plasmodium vivax.
PloS one 2011;6(11):e28126.
2010: Tomoko Yamaguchi; Kenji Kawabata; Emi Kouyama; Ken J Ishii; Kazufumi Katayama; Takayuki Suzuki; Shinnosuke Kurachi; Fuminori Sakurai; Shizuo Akira; Hiroyuki Mizuguchi
Induction of type I interferon by adenovirus-encoded small RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(40):17286-91.
2010: Toshihiro Horii; Hiroki Shirai; Li Jie; Ken J Ishii; Nirianne Q Palacpac; Takahiro Tougan; Mariko Hato; Nobuo Ohta; Albino Bobogare; Nana Arakaki; Yoshitsugu Matsumoto; Junko Namazue; Toyokazu Ishikawa; Shigeharu Ueda; Michiaki Takahashi
Evidences of protection against blood-stage infection of Plasmodium falciparum by the novel protein vaccine SE36.
Parasitology international 2010;59(3):380-6.
2010: Cevayir Coban; Toshihiro Horii; Shizuo Akira; Ken J Ishii
TLR9 and endogenous adjuvants of the whole blood-stage malaria vaccine.
Expert review of vaccines 2010;9(7):775-84.
2010: Cevayir Coban; Masanori Yagi; Keiichi Ohata; Yoshikatsu Igari; Toshihiro Tsukui; Toshihiro Horii; Ken J Ishii; Shizuo Akira
The malarial metabolite hemozoin and its potential use as a vaccine adjuvant.
Allergology international : official journal of the Japanese Society of Allergology 2010;59(2):115-24.
2010: Shohei Koyama; Taiki Aoshi; Takeshi Tanimoto; Yutaro Kumagai; Kouji Kobiyama; Takahiro Tougan; Kazuo Sakurai; Cevayir Coban; Toshihiro Horii; Shizuo Akira; Ken J Ishii
Plasmacytoid dendritic cells delineate immunogenicity of influenza vaccine subtypes.
Science translational medicine 2010;2(25):25ra24.
2010: Thornik Reimer; Michael H Shaw; luigi franchi; Cevayir Coban; Ken J Ishii; Shizuo Akira; Toshihiro Horii; Ana Rodriguez; Gabriel Núñez
Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome.
European journal of immunology 2010;40(3):764-9.
2010: Cevayir Coban; Yoshikatsu Igari; Masanori Yagi; Thornik Reimer; Shohei Koyama; Taiki Aoshi; Keiichi Ohata; Toshihiro Tsukui; Fumihiko Takeshita; Kazuo Sakurai; Takahisa Ikegami; Atsushi Nakagawa; Toshihiro Horii; Gabriel Nuñez; Ken J Ishii; Shizuo Akira
Immunogenicity of whole-parasite vaccines against Plasmodium falciparum involves malarial hemozoin and host TLR9.
Cell host & microbe 2010;7(1):50-61.
2010: Kouji Kobiyama; Nao Jounai; Ken J Ishii; Toshihiro Horii; Koichi Suzuki; Akihide Ryo; Fumihiko Takeshita
Modulation of intracellular signaling using protein-transduction technology.
Critical reviews in immunology 2010;30(5):395-421.
2009: Shohei Koyama; Cevayir Coban; Taiki Aoshi; Toshihiro Horii; Shizuo Akira; Ken J Ishii
Innate immune control of nucleic acid-based vaccine immunogenicity.
Expert review of vaccines 2009;8(8):1099-107.
2009: Takayuki Abe; Yuuki Kaname; Xiaoyu Wen; Hideki Tani; Kohji Moriishi; Satoshi Uematsu; Osamu Takeuchi; Ken J Ishii; Taro Kawai; Shizuo Akira; Yoshiharu Matsuura
Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.
Journal of virology 2009;83(15):7629-40.
2009: Keita Oma; Jizi Zhao; Hirokazu Ezoe; Yukihiro Akeda; Shohei Koyama; Ken J Ishii; Kosuke Kataoka; Kazunori Oishi
Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice.
Vaccine 2009;27(24):3181-8.
2009: Cevayir Coban; Ken J Ishii; Shizuo Akira
Immune interventions of human diseases through toll-like receptors.
Advances in experimental medicine and biology 2009;655():63-80.
2008: Cevayir Coban; Shohei Koyama; Fumihiko Takeshita; Shizuo Akira; Ken J Ishii
Molecular and cellular mechanisms of DNA vaccines.
Human vaccines 2008;4(6):453-6.
2008: Ken J Ishii; Shizuo Akira
Potential link between the immune system and metabolism of nucleic acids.
Current opinion in immunology 2008;20(5):524-9.
2008: Shohei Koyama; Ken J Ishii; Cevayir Coban; Shizuo Akira
Innate immune response to viral infection.
Cytokine 2008;43(3):336-41.
2008: Satoshi Uematsu; Kosuke Fujimoto; Myoung Ho Jang; Bo-Gie Yang; Yun-Jae Jung; Mika Nishiyama; Shintaro Sato; Tohru Tsujimura; Masafumi Yamamoto; Yoshifumi Yokota; Hiroshi Kiyono; Masayuki Miyasaka; Ken J Ishii; Shizuo Akira
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Nature immunology 2008;9(7):769-76.
2008: Ken J Ishii; Shohei Koyama; Atsushi Nakagawa; Cevayir Coban; Shizuo Akira
Host innate immune receptors and beyond: making sense of microbial infections.
Cell host & microbe 2008;3(6):352-63.
2008: Ken J Ishii; Tatsukata Kawagoe; Shohei Koyama; Kosuke Matsui; Himanshu Kumar; Taro Kawai; Satoshi Uematsu; Osamu Takeuchi; Fumihiko Takeshita; Cevayir Coban; Shizuo Akira
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Nature 2008;451(7179):725-9.
2008: Himanshu Kumar; Shohei Koyama; Ken J Ishii; Taro Kawai; Shizuo Akira
Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(2):683-7.
2007: Shohei Koyama; Ken J Ishii; Himanshu Kumar; Takeshi Tanimoto; Cevayir Coban; Satoshi Uematsu; Taro Kawai; Shizuo Akira
Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(7):4711-20.
2007: Masahiro Yamamoto; Satoshi Uematsu; Toru Okamoto; Yoshiharu Matsuura; Shintaro Sato; Himanshu Kumar; Takashi Satoh; Tatsuya Saitoh; Kiyoshi Takeda; Ken J Ishii; Osamu Takeuchi; Taro Kawai; Shizuo Akira
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
The Journal of experimental medicine 2007;204(9):2233-9.
2007: Ken J Ishii; Shizuo Akira
Toll or toll-free adjuvant path toward the optimal vaccine development.
Journal of clinical immunology 2007;27(4):363-71.
2007: Cevayir Coban; Ken J Ishii; Toshihiro Horii; Shizuo Akira
Manipulation of host innate immune responses by the malaria parasite.
Trends in microbiology 2007;15(6):271-8.
2007: Cevayir Coban; Ken J Ishii; Satoshi Uematsu; Nobuko Arisue; Shintaro Sato; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Hajime Hisaeda; Toshihiro Horii; Shizuo Akira
Pathological role of Toll-like receptor signaling in cerebral malaria.
International immunology 2007;19(1):67-79.
2006: Masahiro Yamamoto; Shintaro Sato; Tatsuya Saitoh; Hiroaki Sakurai; Satoshi Uematsu; Taro Kawai; Ken J Ishii; Osamu Takeuchi; Shizuo Akira
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7520-4.
2006: Ken J Ishii; Shizuo Akira
Innate immune recognition of, and regulation by, DNA.
Trends in immunology 2006;27(11):525-32.
2006: Masahiro Yamamoto; Toru Okamoto; Kiyoshi Takeda; Shintaro Sato; Hideki Sanjo; Satoshi Uematsu; Tatsuya Saitoh; Naoki Yamamoto; Hiroaki Sakurai; Ken J Ishii; Shoji Yamaoka; Taro Kawai; Yoshiharu Matsuura; Osamu Takeuchi; Shizuo Akira
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nature immunology 2006;7(9):962-70.
2006: Satoshi Uematsu; Myoung Ho Jang; Nicolas Chevrier; Zijin Guo; Yutaro Kumagai; Masahiro Yamamoto; Hiroki Kato; Nagako Sougawa; Hidenori Matsui; Hirotaka Kuwata; Hiroaki Hemmi; Cevayir Coban; Taro Kawai; Ken J Ishii; Osamu Takeuchi; Masayuki Miyasaka; Kiyoshi Takeda; Shizuo Akira
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Nature immunology 2006;7(8):868-74.
2006: Hiroki Kato; Osamu Takeuchi; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Kosuke Matsui; Satoshi Uematsu; Andreas Jung; Taro Kawai; Ken J Ishii; Osamu Yamaguchi; Kinya Otsu; Tohru Tsujimura; Chang-Sung Koh; Caetano Reis e Sousa; Yoshiharu Matsuura; Takashi Fujita; Shizuo Akira
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature 2006;441(7089):101-5.
2006: Ken J Ishii; Satoshi Uematsu; Shizuo Akira
'Toll' gates for future immunotherapy.
Current pharmaceutical design 2006;12(32):4135-42.
2006: Ken J Ishii; Cevayir Coban; Hiroki Kato; Ken Takahashi; Yuichi Torii; Fumihiko Takeshita; Holger Ludwig; Gerd Sutter; Koichi Suzuki; Hiroaki Hemmi; Shintaro Sato; Masahiro Yamamoto; Satoshi Uematsu; Taro Kawai; Osamu Takeuchi; Shizuo Akira
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Nature immunology 2006;7(1):40-8.
2005: Ken J Ishii; Shizuo Akira
Innate immune recognition of nucleic acids: beyond toll-like receptors.
International journal of cancer. Journal international du cancer 2005;117(4):517-23.
2005: Ken J Ishii; Cevayir Coban; Shizuo Akira
Manifold mechanisms of Toll-like receptor-ligand recognition.
Journal of clinical immunology 2005;25(6):511-21.
2005: Taro Kawai; Ken Takahashi; Shintaro Sato; Cevayir Coban; Himanshu Kumar; Hiroki Kato; Ken J Ishii; Osamu Takeuchi; Shizuo Akira
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Nature immunology 2005;6(10):981-8.
2005: Ken J Ishii; Shizuo Akira
TLR ignores methylated RNA?
Immunity 2005;23(2):111-3.
2005: Satoshi Uematsu; Shintaro Sato; Masahiro Yamamoto; Tomonori Hirotani; Hiroki Kato; Fumihiko Takeshita; Michiyuki Matsuda; Cevayir Coban; Ken J Ishii; Taro Kawai; Osamu Takeuchi; Shizuo Akira
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
The Journal of experimental medicine 2005;201(6):915-23.
2005: Cevayir Coban; Ken J Ishii; Taro Kawai; Hiroaki Hemmi; Shintaro Sato; Satoshi Uematsu; Masahiro Yamamoto; Osamu Takeuchi; Sawako Itagaki; Nirbhay Kumar; Toshihiro Horii; Shizuo Akira
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
The Journal of experimental medicine 2005;201(1):19-25.
2004: Taro Kawai; Shintaro Sato; Ken J Ishii; Cevayir Coban; Hiroaki Hemmi; Masahiro Yamamoto; Kenta Terai; Michiyuki Matsuda; Jun-ichiro Inoue; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
Nature immunology 2004;5(10):1061-8.
2004: Ken J Ishii; Ihsan Gursel; Mayda Gursel; Dennis M Klinman
Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides.
Current opinion in molecular therapeutics 2004;6(2):166-74.
2004: Yoshiyuki Nakajima; Koichi Iwatsuki; Ken J Ishii; Toshiyuki Fujinaka; Kunio Awazu; Toshiki Yoshimine
Development of an intravascular laser treatment with an infrared free electron laser. Selective removal of cholesterol ester in carotid atheromatous plaques.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences 2004;10 Suppl 1():67-9.
2001: Yoshiharu Matsuura; Hideki Tani; Kensuke Suzuki; Tomomi Kimura-Someya; R Suzuki; Hideki Aizaki; Ken J Ishii; Kohji Moriishi; Clinton S Robison; Michael A Whitt; Tatsuo Miyamura
Characterization of pseudotype VSV possessing HCV envelope proteins.
Virology 2001;286(2):263-75.