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Yuji Ishii

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Sayuri Tsujimoto; Kiyomi Tsukimori; Hiroshi Uchi; Tadatoshi Yamaguchi; Midori Yamamoto; masutaka furue; Masaru Himeno; Takumi Ishida; Yuji Ishii; Yuko Onomura; Satoshi O Suzuki; Shinji Takechi; Tomoki Takeda; Hideyuki Yamada
Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Yuji Ishii; Yoshio Nishimura; Kie An; Hideyuki Yamada
ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT.
Tomoki Takeda; Junki Taura; Misaki Fujii; Yuji Ishii; Hideyuki Yamada
Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin.

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All Publications

2013: Sayuri Tsujimoto; Kiyomi Tsukimori; Hiroshi Uchi; Tadatoshi Yamaguchi; Midori Yamamoto; masutaka furue; Masaru Himeno; Takumi Ishida; Yuji Ishii; Yuko Onomura; Satoshi O Suzuki; Shinji Takechi; Tomoki Takeda; Hideyuki Yamada
Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Biochimica et biophysica acta 2013;1830(6):3616-24.
2012: Yuji Ishii; Yoshio Nishimura; Kie An; Hideyuki Yamada
ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT.
Drug metabolism and disposition: the biological fate of chemicals 2012;40(11):2081-9.
2012: Tomoki Takeda; Junki Taura; Misaki Fujii; Yuji Ishii; Hideyuki Yamada
Dioxin silences gonadotropin expression in perinatal pups by inducing histone deacetylases: a new insight into the mechanism for the imprinting of sexual immaturity by dioxin.
The Journal of biological chemistry 2012;287(22):18440-50.
2012: Takayuki Koga; Tomoki Takeda; Kiyomi Tsukimori; Hiroshi Uchi; masutaka furue; Masaru Himeno; Takumi Ishida; Yuji Ishii; Midori Yamamoto; Hideyuki Yamada
Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid.
PloS one 2012;7(7):e40322.
2012: Yuji Ishii; Peter I Mackenzie; Yuu Miyauchi; Naoko Iida; Hideyuki Yamada
Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols.
Biological & pharmaceutical bulletin 2012;35(10):1811-7.
2011: Tomoki Takeda; Junki Taura; Misaki Fujii; Yuji Ishii; Takayuki Koga; Hideyuki Yamada
[The effect of maternal exposure to dioxin on fetal steroidogenesis in the steroidogenic organs].
Fukuoka igaku zasshi = Hukuoka acta medica 2011;102(4):159-66.
2011: Tomoki Takeda; Midori Yamamoto; Masaru Himeno; Shinji Takechi; Tadatoshi Yamaguchi; Takumi Ishida; Yuji Ishii; Hideyuki Yamada
2,3,7,8-tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries.
The Journal of toxicological sciences 2011;36(2):221-9.
2010: Takumi Ishida; Yuki Matsumoto; Tomoki Takeda; Takayuki Koga; Yuji Ishii; Hideyuki Yamada
Distribution of 14C-2,3,7,8-tetrachlorodibenzo-p-dioxin to the brain and peripheral tissues of fetal rats and its comparison with adults.
The Journal of toxicological sciences 2010;35(4):563-9.
2010: Yuki Matsumoto; Takumi Ishida; Tomoki Takeda; Takayuki Koga; Misaki Fujii; Yuji Ishii; Yoshinori Fujimura; Daisuke Miura; Hiroyuki Wariishi; Hideyuki Yamada
Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis.
The Journal of toxicological sciences 2010;35(3):365-73.
2010: Yuji Ishii; Shuso Takeda; Hideyuki Yamada
Modulation of UDP-glucuronosyltransferase activity by protein-protein association.
Drug metabolism reviews 2010;42(1):145-58.
2010: Arief Nurrochmad; Yuji Ishii; Hitomi Nakanoh; Tae Inoue; Toru Horie; Kazumi Sugihara; Shigeru Ohta; Akinobu Taketomi; Yoshihiko Maehara; Hideyuki Yamada
Activation of morphine glucuronidation by fatty acyl-CoAs and its plasticity: a comparative study in humans and rodents including chimeric mice carrying human liver.
Drug metabolism and pharmacokinetics 2010;25(3):262-73.
2010: Yuji Ishii; Arief Nurrochmad; Hideyuki Yamada
Modulation of UDP-glucuronosyltransferase activity by endogenous compounds.
Drug metabolism and pharmacokinetics 2010;25(2):134-48.
2009: Tomoki Takeda; Yuki Matsumoto; Takayuki Koga; Junpei Mutoh; Yoshio Nishimura; Takao Shimazoe; Yuji Ishii; Takumi Ishida; Hideyuki Yamada
Maternal exposure to dioxin disrupts gonadotropin production in fetal rats and imprints defects in sexual behavior.
The Journal of pharmacology and experimental therapeutics 2009;329(3):1091-9.
2009: Takumi Ishida; Yuichi Sakai; Yuji Ishii; masutaka furue; Hideyuki Yamada
[The accelerated excretion of 2,3,4,7,8-pentachlorodibenzofuran by Cholebine].
Fukuoka igaku zasshi = Hukuoka acta medica 2009;100(5):210-6.
2009: Takumi Ishida; Tomoki Takeda; Takayuki Koga; Masahiro Yahata; Ayako Ike; Chihiro Kuramoto; Junko Taketoh; Isamu Hashiguchi; Akifumi Akamine; Yuji Ishii; Hideyuki Yamada
Attenuation of 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity by resveratrol: a comparative study with different routes of administration.
Biological & pharmaceutical bulletin 2009;32(5):876-81.
2009: Shuso Takeda; Yuji Ishii; Megumi Iwanaga; Arief Nurrochmad; Yuji Ito; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction.
Molecular pharmacology 2009;75(4):956-64.
2008: Takumi Ishida; Yuji Ishii; Masayo Kawakami; Junpei Mutoh; Shuso Takeda; Yoshitaka Tanaka; Masahiro Yahata; Hiroko Baba; Hideaki Fujita; Hideyuki Yamada
Proteasome affects the expression of aryl hydrocarbon receptor-regulated proteins.
Environmental toxicology and pharmacology 2008;26(3):348-54.
2007: Yoshio Nishimura; Shingo Maeda; Shin-ichi Ikushiro; Peter I Mackenzie; Yuji Ishii; Hideyuki Yamada
Inhibitory effects of adenine nucleotides and related substances on UDP-glucuronosyltransferase: structure-effect relationships and evidence for an allosteric mechanism.
Biochimica et biophysica acta 2007;1770(11):1557-66.
2007: Yuji Ishii; Megumi Iwanaga; Yoshio Nishimura; Shuso Takeda; Shin-ichi Ikushiro; Kiyoshi Nagata; Yasushi Yamazoe; Peter I Mackenzie; Hideyuki Yamada
Protein-protein interactions between rat hepatic cytochromes P450 (P450s) and UDP-glucuronosyltransferases (UGTs): evidence for the functionally active UGT in P450-UGT complex.
Drug metabolism and pharmacokinetics 2007;22(5):367-76.
2007: Junpei Mutoh; Takumi Ishida; Yuji Ishii; Hideyuki Yamada
[Effect on the expression of testicular steroidogenic enzymes in fetal mouse by maternal exposure to TCDD].
Fukuoka igaku zasshi = Hukuoka acta medica 2007;98(5):203-7.
2007: Junko Taketoh; Junpei Mutoh; Tomoki Takeda; Tadashi Ogishima; Shuso Takeda; Yuji Ishii; Takumi Ishida; Hideyuki Yamada
Suppression of fetal testicular cytochrome P450 17 by maternal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: a mechanism involving an initial effect on gonadotropin synthesis in the pituitary.
Life sciences 2007;80(14):1259-67.
2006: Shuso Takeda; Yurie Kitajima; Yuji Ishii; Yoshio Nishimura; Peter I Mackenzie; Kazuta Oguri; Hideyuki Yamada
Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1277-82.
2006: Kazuharu Okamura; Yuji Ishii; Shin-ichi Ikushiro; Peter I Mackenzie; Hideyuki Yamada
Fatty acyl-CoA as an endogenous activator of UDP-glucuronosyltransferases.
Biochemical and biophysical research communications 2006;345(4):1649-56.
2006: Hideyuki Yamada; Yuji Ishii; Midori Yamamoto; Kazuta Oguri
Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism.
Current drug metabolism 2006;7(4):397-409.
2006: Junpei Mutoh; Junko Taketoh; Kazuharu Okamura; Tetsushi Kagawa; Takumi Ishida; Yuji Ishii; Hideyuki Yamada
Fetal pituitary gonadotropin as an initial target of dioxin in its impairment of cholesterol transportation and steroidogenesis in rats.
Endocrinology 2006;147(2):927-36.
2005: Shuso Takeda; Yuji Ishii; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4.
Biological & pharmaceutical bulletin 2005;28(10):2026-7.
2005: Yuji Ishii; Daisuke Akazawa; Yasunobu Aoki; Hideyuki Yamada; Kazuta Oguri
Suppression of carbonic anhydrase III mRNA level by an aryl hydrocarbon receptor ligand in primary cultured hepatocytes of rat.
Biological & pharmaceutical bulletin 2005;28(6):1087-90.
2005: Takumi Ishida; Shoko Kan-o; Junpei Mutoh; Shuso Takeda; Yuji Ishii; Isamu Hashiguchi; Akifumi Akamine; Hideyuki Yamada
2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced change in intestinal function and pathology: evidence for the involvement of arylhydrocarbon receptor-mediated alteration of glucose transportation.
Toxicology and applied pharmacology 2005;205(1):89-97.
2005: Yuji Ishii; Takumi Ishida; Junpei Mutoh; Hideyuki Yamada; Kazuta Oguri
[Possible candidates for the compound which is expected to attenuate dioxin toxicity].
Fukuoka igaku zasshi = Hukuoka acta medica 2005;96(5):204-13.
2005: Shuso Takeda; Yuji Ishii; Megumi Iwanaga; Peter I Mackenzie; Kiyoshi Nagata; Yasushi Yamazoe; Kazuta Oguri; Hideyuki Yamada
Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4.
Molecular pharmacology 2005;67(3):665-72.
2005: Yuji Ishii; Shuso Takeda; Hideyuki Yamada; Kazuta Oguri
Functional protein-protein interaction of drug metabolizing enzymes.
Frontiers in bioscience : a journal and virtual library 2005;10():887-95.
2004: Yuji Ishii; Aya Miyoshi; Daisuke Maji; Hideyuki Yamada; Kazuta Oguri
Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 (UGT2B21) and 2B22 in COS-7 cells enhances UGT2B21-catalyzed chloramphenicol glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(10):1057-60.
2004: Takumi Ishida; Tomomi Oshimo; Akihisa Nishimura; Junpei Mutoh; Yuji Ishii; Nobuyuki Koga; Hideyuki Yamada; Isamu Hashiguchi; Akifumi Akamine; Kazuta Oguri
Reduction of the toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice using an antiulcer drug, geranylgeranylacetone.
Biological & pharmaceutical bulletin 2004;27(9):1397-402.
2004: Ken-ichiro Taura; Eri Naito; Yuji Ishii; Masa-aki Mori; Kazuta Oguri; Hideyuki Yamada
Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactions.
Biological & pharmaceutical bulletin 2004;27(1):56-60.
2003: Hideyuki Yamada; Kumiko Ishii; Yuji Ishii; Ichiro Ieiri; Syunji Nishio; Takato Morioka; Kazuta Oguri
Formation of highly analgesic morphine-6-glucuronide following physiologic concentration of morphine in human brain.
The Journal of toxicological sciences 2003;28(5):395-401.
2001: Yuji Ishii; A Miyoshi; R Watanabe; K Tsuruda; Makoto Tsuda; Y Yamaguchi-Nagamatsu; K Yoshisue; M Tanaka; D Maji; S Ohgiya; Kazuta Oguri
Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation.
Molecular pharmacology 2001;60(5):1040-8.
2001: Y Yoshioka; Yuji Ishii; Takumi Ishida; Hideyuki Yamada; Kazuta Oguri; K Motojima
[Suppression of stress proteins, GRP78, GRP94, calreticulin and calnexin in liver endoplasmic reticulum of rat treated with a highly toxic coplanar PCB].
Fukuoka igaku zasshi = Hukuoka acta medica 2001;92(5):201-16.
2001: Yuji Ishii; H Kato; M Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Hideyuki Yamada; Kazuta Oguri
Effects of a highly toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl on intermediary metabolism: reduced triose phosphate content in rat liver cytosol.
Fukuoka igaku zasshi = Hukuoka acta medica 2001;92(5):190-200.
2000: Hisakata Yamada; H Matsunaga; K Tsuji; S Matsumoto; Midori Yamamoto; Yuji Ishii; Curtis J Omiecinski; Kazuta Oguri
Sequence analyses of CYP2B genes and catalytic profiles for P450s in Qdj:Sprague-dawley rats that lack response to the phenobarbital-mediated induction of CYP2B2.
The Journal of pharmacology and experimental therapeutics 2000;295(3):986-93.
2000: M Ikeda; Yuji Ishii; H Kato; D Akazawa; M Hatsumura; Takumi Ishida; K Matsusue; Hideyuki Yamada; Kazuta Oguri
Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3, 3',4,4',5-pentachlorobiphenyl.
Archives of biochemistry and biophysics 2000;380(1):159-64.
2000: Ken-ichiro Taura; Hisakata Yamada; Y Hagino; Yuji Ishii; Masatomo Mori; Kazuta Oguri
Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase.
Biochemical and biophysical research communications 2000;273(3):1048-52.
1999: K Matsusue; Yuji Ishii; Noritaka Ariyoshi; Kazuta Oguri
A highly toxic coplanar polychlorinated biphenyl compound suppresses Delta5 and Delta6 desaturase activities which play key roles in arachidonic acid synthesis in rat liver.
Chemical research in toxicology 1999;12(12):1158-65.
1999: A Fukuda; Yuji Ishii; K Tasaki; K Matsusue; Takumi Ishida; Kazuta Oguri
[Induction of molecular chaperones HSP70 and HSP90 in rat liver cytosol by a highly toxic coplanar PCB].
Fukuoka igaku zasshi = Hukuoka acta medica 1999;90(5):259-71.
1999: K Tasaki; Yuji Ishii; Takumi Ishida; Kazuta Oguri
[Suppression of stress proteins in endoplasmic reticulum in liver cytosol of rats treated with a highly toxic coplanar PCB].
Fukuoka igaku zasshi = Hukuoka acta medica 1999;90(5):251-8.
1998: Takumi Ishida; Yuji Ishii; A Fukuda; K Tasaki; Kazuta Oguri
Induction of a cytosolic 54 kDa protein in rat liver that is highly homologous to selenium-binding protein.
Environmental toxicology and pharmacology 1998;6(4):249-55.
1997: Takumi Ishida; Yuji Ishii; K Tasaki; Noritaka Ariyoshi; Kazuta Oguri
[Production of antibody against cytosolic 54 kDa protein in rat liver--evidence of the significant induction by a highly toxic coplanar polychlorinated biphenyl].
Fukuoka igaku zasshi = Hukuoka acta medica 1997;88(5):135-43.
1997: K Matsusue; Yuji Ishii; Noritaka Ariyoshi; Kazuta Oguri
A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver.
Toxicology letters 1997;91(2):99-104.
1997: Yuji Ishii; A Takami; K Tsuruda; A Kurogi; Hisakata Yamada; Kazuta Oguri
Induction of two UDP-glucuronosyltransferase isoforms sensitive to phenobarbital that are involved in morphine glucuronidation: production of isoform-selective antipeptide antibodies toward UGT1.1r and UGT2B1.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(2):163-7.
1997: Yuji Ishii; H Kato; M Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri
Significant suppression of rat liver aldolase B by a toxic coplanar polychlorinated biphenyl, 3,3',4,4',5-pentachlorobiphenyl.
Toxicology 1997;116(1-3):193-9.
1996: Yuji Ishii; M Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri
Significant induction of a 54-kDa protein in rat liver with homologous alignment to mouse selenium binding protein by a coplanar polychlorinated biphenyl, 3,4,5,3',4'-pentachlorobiphenyl and 3-methylcholanthrene.
Toxicology letters 1996;87(1):1-9.
1996: Yuji Ishii; M Hatsumura; Takumi Ishida; Noritaka Ariyoshi; Kazuta Oguri
A coplanar PCB induces a selenium binding protein as a major cytosolic protein in rat liver.
Chemosphere 1996;32(3):509-15.
1996: Kazuta Oguri; A Kurogi; K Yamabe; M Tanaka; K Yoshisue; Yuji Ishii; H Yoshimura
Purification of a phenobarbital-inducible UDP-glucuronosyltransferase isoform from dog liver which catalyzes morphine and testosterone glucuronidation.
Archives of biochemistry and biophysics 1996;325(2):159-66.
1995: M Hatsumura; Takumi Ishida; Yuji Ishii; Noritaka Ariyoshi; Kazuta Oguri; H Yoshimura
[Effect of a coplanar PCB on lipid metabolism: the remarkable difference between rats and guinea pigs].
Fukuoka igaku zasshi = Hukuoka acta medica 1995;86(5):135-43.
1994: Yuji Ishii; K Tsuruda; M Tanaka; Kazuta Oguri
Purification of a phenobarbital-inducible morphine UDP-glucuronyltransferase isoform, absent from Gunn rat liver.
Archives of biochemistry and biophysics 1994;315(2):345-51.
1994: Noritaka Ariyoshi; M Tanaka; Yuji Ishii; Kazuta Oguri
Purification and characterization of dog liver microsomal epoxide hydrolase.
Journal of biochemistry 1994;115(5):985-90.
1994: H Fujisaki; M Mise; Yuji Ishii; Hisakata Yamada; Kazuta Oguri
Strychnine and brucine as the potent inducers of drug metabolizing enzymes in rat liver: different profiles from phenobarbital on the induction of cytochrome P450 and UDP-glucuronosyltransferase.
The Journal of pharmacology and experimental therapeutics 1994;268(2):1024-31.
1993: Yuji Ishii; Kazuta Oguri; H Yoshimura
Purification and characterization of a morphine UDP-glucuronyltransferase isoform from untreated rat liver.
Biological & pharmaceutical bulletin 1993;16(8):754-8.
1993: Hisakata Yamada; H Fujisaki; H Kaneko; Yuji Ishii; T Hamaguchi; Kazuta Oguri
Picrotoxin as a potent inducer of rat hepatic cytochrome P450, CYP2B1 and CYP2B2.
Biochemical pharmacology 1993;45(9):1783-9.
1993: Kazuta Oguri; Y Koga; M Tsuda; Noritaka Ariyoshi; Yuji Ishii; Hisakata Yamada; H Yoshimura
[Inducing ability of co-planar PCBs toward bilirubin UDP-glucuronyltransferase of liver microsomes: the remarkable difference between guinea pigs and rats].
Fukuoka igaku zasshi = Hukuoka acta medica 1993;84(5):175-80.
1992: Takeshi Nakano; Hiromi Ishibashi; M Matsui; T Yasutake; Yuji Ishii; Kazufumi Dohmen; Kohei Nagasawa; Y Niho
[A case of primary biliary cirrhosis with negative anti-mitochondrial antibody anteceded by rheumatoid arthritis].
Fukuoka igaku zasshi = Hukuoka acta medica 1992;83(3):144-8.