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Tak Yee Aw

Research Profile

Chemicals & Drugs

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Oxidation-Reduction

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Oxidative Stress

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Publications

TOP 3
Wei Li; Ronald E Maloney; J Steven Alexander; Magdalena L Circu; Tak Yee Aw
Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: role for glutathione-dependent metabolism of methylglyoxal.
Isaac Downs; Jianfeng Liu; Patrick A Adegboyega; Tak Yee Aw; Maureen N Ajuebor
Vα14iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism.
Magdalena L Circu; Tak Yee Aw
Glutathione and modulation of cell apoptosis.

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All Publications

2013: Wei Li; Ronald E Maloney; J Steven Alexander; Magdalena L Circu; Tak Yee Aw
Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: role for glutathione-dependent metabolism of methylglyoxal.
Free radical biology & medicine 2013;54():51-61.
2012: Isaac Downs; Jianfeng Liu; Patrick A Adegboyega; Tak Yee Aw; Maureen N Ajuebor
Vα14iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism.
Biochemical and biophysical research communications 2012;428(2):245-51.
2012: Magdalena L Circu; Tak Yee Aw
Glutathione and modulation of cell apoptosis.
Biochimica et biophysica acta 2012;1823(10):1767-77.
2012: Tak Yee Aw
Tissue oxidative stress revisited: significance of ROS and redox signaling.
Seminars in cell & developmental biology 2012;23(7):721.
2012: Magdalena L Circu; Tak Yee Aw
Intestinal redox biology and oxidative stress.
Seminars in cell & developmental biology 2012;23(7):729-37.
2012: Delira Robbins; Holly Van Remmen; David B Wang; Stephan N Witt; Jennifer A Wittwer; Tak Yee Aw; Magdalena L Circu; Sarah Codarin; Ting-Ting Huang; Ronald L Klein; Arlan G Richardson; Yunfeng Zhao
Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase.
Cancer science 2012;103(8):1429-33.
2012: Wei Li; Carmina Busu; Magdalena L Circu; Tak Yee Aw
Glutathione in cerebral microvascular endothelial biology and pathobiology: implications for brain homeostasis.
International journal of cell biology 2012;2012():434971.
2012: Isaac Downs; Jianfeng Liu; Patrick A Adegboyega; Tak Yee Aw; Maureen N Ajuebor
The ROS scavenger, NAC, regulates hepatic Vα14iNKT cells signaling during Fas mAb-dependent fulminant liver failure.
PloS one 2012;7(6):e38051.
2012: Cheng Zhang; Tak Yee Aw; Cynthia Rodriguez; James Spaulding; June Feng
Age-dependent and tissue-related glutathione redox status in a mouse model of Alzheimer's disease.
Journal of Alzheimer's disease : JAD 2012;28(3):655-66.
2011: J William Langston; Wei Li; Lynn Harrison; Tak Yee Aw
Activation of promoter activity of the catalytic subunit of γ-glutamylcysteine ligase (GCL) in brain endothelial cells by insulin requires antioxidant response element 4 and altered glycemic status: implication for GCL expression and GSH synthesis.
Free radical biology & medicine 2011;51(9):1749-57.
2011: Magdalena L Circu; Tak Yee Aw
Redox biology of the intestine.
Free radical research 2011;45(11-12):1245-66.
2011: Cheng Zhang; Cynthia Rodriguez; Tak Yee Aw; Magdalena L Circu; June Feng
S-Glutathionyl quantification in the attomole range using glutaredoxin-3-catalyzed cysteine derivatization and capillary gel electrophoresis with laser-induced fluorescence detection.
Analytical and bioanalytical chemistry 2011;401(7):2165-75.
2011: William S Wright; Wendy Leskova; Robert M McElhatten; Singh Yadav Amit; Tak Yee Aw; Carmina Busu; Norman R Harris
Influence of glutathione on the electroretinogram in diabetic and non-diabetic rats.
Current eye research 2011;36(9):831-7.
2011: Yong Joo Lee; Elodie Burlet; Floyd Galiano; Magdalena L Circu; Tak Yee Aw; B Jill Williams; Stephan N Witt
Phosphate and succinate use different mechanisms to inhibit sugar-induced cell death in yeast: insight into the Crabtree effect.
The Journal of biological chemistry 2011;286(23):20267-74.
2011: Magdalena L Circu; Ronald E Maloney; Tak Yee Aw
Disruption of pyridine nucleotide redox status during oxidative challenge at normal and low-glucose states: implications for cellular adenosine triphosphate, mitochondrial respiratory activity, and reducing capacity in colon epithelial cells.
Antioxidants & redox signaling 2011;14(11):2151-62.
2010: June A D'Angelo; Eleonora Dehlink; Barbara Platzer; Peter Dwyer; Magdalena L Circu; Jone Garay; Tak Yee Aw; Edda Fiebiger; Bonny L Dickinson
The cystine/glutamate antiporter regulates dendritic cell differentiation and antigen presentation.
Journal of immunology (Baltimore, Md. : 1950) 2010;185(6):3217-26.
2010: Maureen N Ajuebor; Qingling Chen; Robert M Strieter; Patrick A Adegboyega; Tak Yee Aw
V(alpha)14iNKT cells promote liver pathology during adenovirus infection by inducing CCL5 production: implications for gene therapy.
Journal of virology 2010;84(17):8520-9.
2010: Magdalena L Circu; Tak Yee Aw
Reactive oxygen species, cellular redox systems, and apoptosis.
Free radical biology & medicine 2010;48(6):749-62.
2009: Masahiro Okouchi; Naotsuka Okayama; Tak Yee Aw
Preservation of cellular glutathione status and mitochondrial membrane potential by N-acetylcysteine and insulin sensitizers prevent carbonyl stress-induced human brain endothelial cell apoptosis.
Current neurovascular research 2009;6(4):267-78.
2009: Magdalena L Circu; Mary Pat Moyer; Lynn Harrison; Tak Yee Aw
Contribution of glutathione status to oxidant-induced mitochondrial DNA damage in colonic epithelial cells.
Free radical biology & medicine 2009;47(8):1190-8.
2009: Tony W H Li; Qingsong Zhang; Pilsoo Oh; Meng Xia; Hui Chen; Sean Bemanian; Natalie Lastra; Magda Circ; Mary Pat Moyer; José M Mato; Tak Yee Aw; Shelly C Lu
S-Adenosylmethionine and methylthioadenosine inhibit cellular FLICE inhibitory protein expression and induce apoptosis in colon cancer cells.
Molecular pharmacology 2009;76(1):192-200.
2009: Magdalena L Circu; Sarah Stringer; Carol A Rhoads; Mary Pat Moyer; Tak Yee Aw
The role of GSH efflux in staurosporine-induced apoptosis in colonic epithelial cells.
Biochemical pharmacology 2009;77(1):76-85.
2008: Will Langston; Magdalena L Circu; Tak Yee Aw
Insulin stimulation of gamma-glutamylcysteine ligase catalytic subunit expression increases endothelial GSH during oxidative stress: influence of low glucose.
Free radical biology & medicine 2008;45(11):1591-9.
2008: Magdalena L Circu; Cynthia Rodriguez; Ronald E Maloney; Mary Pat Moyer; Tak Yee Aw
Contribution of mitochondrial GSH transport to matrix GSH status and colonic epithelial cell apoptosis.
Free radical biology & medicine 2008;44(5):768-78.
2007: Masahiro Okouchi; Oleksandr Ekshyyan; Magdalena Maracine; Tak Yee Aw
Neuronal apoptosis in neurodegeneration.
Antioxidants & redox signaling 2007;9(8):1059-96.
2006: Masahiro Okouchi; Naotsuka Okayama; Jonathan Steven Alexander; Tak Yee Aw
NRF2-dependent glutamate-L-cysteine ligase catalytic subunit expression mediates insulin protection against hyperglycemia- induced brain endothelial cell apoptosis.
Current neurovascular research 2006;3(4):249-61.
2006: Heather L Spaulding; Fumito Saijo; Richard H Turnage; J Steven Alexander; Tak Yee Aw; Theodore J Kalogeris
Apolipoprotein A-IV attenuates oxidant-induced apoptosis in mitotic competent, undifferentiated cells by modulating intracellular glutathione redox balance.
American journal of physiology. Cell physiology 2006;290(1):C95-C103.
2005: Masahiro Okouchi; Naotsuka Okayama; Tak Yee Aw
Hyperglycemia potentiates carbonyl stress-induced apoptosis in naïve PC-12 cells: relationship to cellular redox and activator protease factor-1 expression.
Current neurovascular research 2005;2(5):375-86.
2005: Oleksandr Ekshyyan; Tak Yee Aw
Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1.
Cell death and differentiation 2005;12(8):1066-77.
2005: Tak Yee Aw
Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility.
Toxicology and applied pharmacology 2005;204(3):320-8.
2005: Masahiro Okouchi; Naotsuka Okayama; Tak Yee Aw
Differential susceptibility of naive and differentiated PC-12 cells to methylglyoxal-induced apoptosis: influence of cellular redox.
Current neurovascular research 2005;2(1):13-22.
2004: Oleksandr Ekshyyan; Tak Yee Aw
Apoptosis: a key in neurodegenerative disorders.
Current neurovascular research 2004;1(4):355-71.
2004: H Ichikawa; S Kokura; Tak Yee Aw
Role of endothelial mitochondria in oxidant production and modulation of neutrophil adherence.
Journal of vascular research 2004;41(5):432-44.
2004: Taniai Hisashi; Ian N Hines; Sulaiman Bharwani; Ronald E Maloney; Yuji Nimura; Bifeng Gao; Sonia C Flores; Joe M McCord; Matthew B Grisham; Tak Yee Aw
Susceptibility of murine periportal hepatocytes to hypoxia-reoxygenation: role for NO and Kupffer cell-derived oxidants.
Hepatology (Baltimore, Md.) 2004;39(6):1544-52.
2004: Oleksandr Ekshyyan; Tak Yee Aw
Apoptosis in acute and chronic neurological disorders.
Frontiers in bioscience : a journal and virtual library 2004;9():1567-76.
2003: Seiji Tsunada; Ryuichi Iwakiri; Kazuma Fujimoto; Tak Yee Aw
Chronic lipid hydroperoxide stress suppresses mucosal proliferation in rat intestine: potentiation of ornithine decarboxylase activity by epidermal growth factor.
Digestive diseases and sciences 2003;48(12):2333-41.
2003: Tak Yee Aw
Cellular redox: a modulator of intestinal epithelial cell proliferation.
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society 2003;18():201-4.
2003: Seiji Tsunada; R Iwakiri; Hibiki Ootani; Tak Yee Aw; K Fujimoto
Redox imbalance in the colonic mucosa of ulcerative colitis.
Scandinavian journal of gastroenterology 2003;38(9):1002-3.
2003: Hannah V Carey; Carol A Rhoads; Tak Yee Aw
Hibernation induces glutathione redox imbalance in ground squirrel intestine.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 2003;173(4):269-76.
2003: Erin K Pias; Oleksandr Ekshyyan; Carol A Rhoads; John W Fuseler; Lynn Harrison; Tak Yee Aw
Differential effects of superoxide dismutase isoform expression on hydroperoxide-induced apoptosis in PC-12 cells.
The Journal of biological chemistry 2003;278(15):13294-301.
2003: Seiji Tsunada; Ryuichi Iwakiri; Takahiro Noda; Kazuma Fujimoto; John W Fuseler; Carol A Rhoads; Tak Yee Aw
Chronic exposure to subtoxic levels of peroxidized lipids suppresses mucosal cell turnover in rat small intestine and reversal by glutathione.
Digestive diseases and sciences 2003;48(1):210-22.
2002: Ricarda Carlisle; Carol A Rhoads; Tak Yee Aw; Lynn Harrison
Endothelial cells maintain a reduced redox environment even as mitochondrial function declines.
American journal of physiology. Cell physiology 2002;283(6):C1675-86.
2002: Erin K Pias; Tak Yee Aw
Early redox imbalance mediates hydroperoxide-induced apoptosis in mitotic competent undifferentiated PC-12 cells.
Cell death and differentiation 2002;9(9):1007-16.
2002: Yudai Gotoh; Takahiro Noda; Ryuichi Iwakiri; Kazuma Fujimoto; Carol A Rhoads; Tak Yee Aw
Lipid peroxide-induced redox imbalance differentially mediates CaCo-2 cell proliferation and growth arrest.
Cell proliferation 2002;35(4):221-35.
2002: Erin K Pias; Tak Yee Aw
Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2002;16(8):781-90.
2002: Adela Cota-Gomez; Natalia C Flores; Coral Cruz; Anna Casullo; Tak Yee Aw; Hiroshi Ichikawa; Jerome Schaack; Robert I Scheinman; Sonia C Flores
The human immunodeficiency virus-1 Tat protein activates human umbilical vein endothelial cell E-selectin expression via an NF-kappa B-dependent mechanism.
The Journal of biological chemistry 2002;277(17):14390-9.
2002: Takahiro Noda; Ryuichi Iwakiri; Kazuma Fujimoto; Carol A Rhoads; Tak Yee Aw
Exogenous cysteine and cystine promote cell proliferation in CaCo-2 cells.
Cell proliferation 2002;35(2):117-29.
2001: Takahiro Noda; Ryuichi Iwakiri; Kazuma Fujimoto; Tak Yee Aw
Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(12):2131-9.
2001: Steven P Jones; WG Girod; Keith Marotti; Tak Yee Aw; David J Lefer
Acute exposure to a high cholesterol diet attenuates myocardial ischemia-reperfusion injury in cholesteryl ester transfer protein mice.
Coronary artery disease 2001;12(1):37-44.
2001: Ryuichi Iwakiri; Y Gotoh; T Noda; H Sugihara; K Fujimoto; John W Fuseler; Tak Yee Aw
Programmed cell death in rat intestine: effect of feeding and fasting.
Scandinavian journal of gastroenterology 2001;36(1):39-47.
2001: S Kokura; Carol A Rhoads; Robert E Wolf; T Yoshikawa; D Neil Granger; Tak Yee Aw
NF kappa b signaling in posthypoxic endothelial cells: relevance to E-selectin expression and neutrophil adhesion.
Journal of vascular research 2001;38(1):47-58.
2000: T G Wang; Y Gotoh; Merilyn H Jennings; Carol A Rhoads; Tak Yee Aw
Lipid hydroperoxide-induced apoptosis in human colonic CaCo-2 cells is associated with an early loss of cellular redox balance.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2000;14(11):1567-76.
2000: S Kokura; Robert E Wolf; T Yoshikawa; D Neil Granger; Tak Yee Aw
Postanoxic T lymphocyte-endothelial cell interactions induce tumor necrosis factor-alpha production and neutrophil adhesion: role of very late antigen-4/vascular cell adhesion molecule-1.
Circulation research 2000;86(12):1237-44.
2000: S Kokura; Robert E Wolf; T Yoshikawa; D Neil Granger; Tak Yee Aw
T-lymphocyte-derived tumor necrosis factor exacerbates anoxia-reoxygenation-induced neutrophil-endothelial cell adhesion.
Circulation research 2000;86(2):205-13.
2000: S Kokura; Robert E Wolf; T Yoshikawa; H Ichikawa; D Neil Granger; Tak Yee Aw
Endothelial cells exposed to anoxia/reoxygenation are hyperadhesive to T-lymphocytes: kinetics and molecular mechanisms.
Microcirculation (New York, N.Y. : 1994) 2000;7(1):13-23.
2000: Tak Yee Aw
Intracellular compartmentation of organelles and gradients of low molecular weight species.
International review of cytology 2000;192():223-53.
1999: WG Girod; Steven P Jones; N Sieber; Tak Yee Aw; David J Lefer
Effects of hypercholesterolemia on myocardial ischemia-reperfusion injury in LDL receptor-deficient mice.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2776-81.
1999: Tak Yee Aw
Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine.
The American journal of clinical nutrition 1999;70(4):557-65.
1999: S Kokura; Robert E Wolf; T Yoshikawa; D Neil Granger; Tak Yee Aw
Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance.
Circulation research 1999;84(5):516-24.
1998: Om Prakash; B H Joshi; P Zhang; Tak Yee Aw; S Teng; M Ali; Judd E Shellito; Steve Nelson
Transgenic mouse model of ethanol as a cofactor in HIV disease.
Alcoholism, clinical and experimental research 1998;22(5 Suppl):266S-268S.
1998: Tak Yee Aw
Determinants of intestinal detoxication of lipid hydroperoxides.
Free radical research 1998;28(6):637-46.
1998: T S LeGrand; Tak Yee Aw
Chronic hypoxia alters glucose utilization during GSH-dependent detoxication in rat small intestine.
The American journal of physiology 1998;274(2 Pt 1):G376-84.
1997: H Ichikawa; S Flores; P R Kvietys; Robert E Wolf; T Yoshikawa; D N Granger; Tak Yee Aw
Molecular mechanisms of anoxia/reoxygenation-induced neutrophil adherence to cultured endothelial cells.
Circulation research 1997;81(6):922-31.
1997: Tak Yee Aw
Luminal peroxides in intestinal thiol-disulfide balance and cell turnover.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 1997;118(3):479-85.
1997: H Ichikawa; Robert E Wolf; Tak Yee Aw; N Ohno; LL Coe; D Neil Granger; T Yoshikawa; J Steven Alexander
Exogenous xanthine promotes neutrophil adherence to cultured endothelial cells.
The American journal of physiology 1997;273(2 Pt 1):G342-7.
1997: Om Prakash; S Teng; M Ali; X Zhu; Roy Coleman; R A Dabdoub; R Chambers; Tak Yee Aw; Sonia C Flores; B H Joshi
The human immunodeficiency virus type 1 Tat protein potentiates zidovudine-induced cellular toxicity in transgenic mice.
Archives of biochemistry and biophysics 1997;343(2):173-80.
1997: T S LeGrand; Tak Yee Aw
Chronic hypoxia, glutathione-dependent detoxication, and metabolic instability in rat small intestine.
The American journal of physiology 1997;272(2 Pt 1):G328-34.
1996: T S LeGrand; Tak Yee Aw
Chronic hypoxia and glutathione-dependent detoxication in rat small intestine.
The American journal of physiology 1996;270(4 Pt 1):G725-9.
1995: Ryuichi Iwakiri; C A Rhoads; Tak Yee Aw
Determinants of hydroperoxide detoxification in diabetic rat intestine: effect of insulin and fasting on the glutathione redox cycle.
Metabolism: clinical and experimental 1995;44(11):1462-8.
1995: Tak Yee Aw
Assay of thiols and disulfides in intestinal lymph.
Methods in enzymology 1995;251():221-8.
1994: Tak Yee Aw; C A Rhoads
Glucose regulation of hydroperoxide metabolism in rat intestinal cells. Stimulation of reduced nicotinamide adenine dinucleotide phosphate supply.
The Journal of clinical investigation 1994;94(6):2426-34.
1994: D L Osborne; Tak Yee Aw; G Cepinskas; P R Kvietys
Development of ischemia/reperfusion tolerance in the rat small intestine. An epithelium-independent event.
The Journal of clinical investigation 1994;94(5):1910-8.
1994: Tak Yee Aw
Biliary glutathione promotes the mucosal metabolism of luminal peroxidized lipids by rat small intestine in vivo.
The Journal of clinical investigation 1994;94(3):1218-25.
1994: G Cepinskas; P R Kvietys; Tak Yee Aw
Omega 3-lipid peroxides injure CaCo-2 cells: relationship to the development of reduced glutathione antioxidant systems.
Gastroenterology 1994;107(1):80-6.
1992: Tak Yee Aw; M W Williams
Intestinal absorption and lymphatic transport of peroxidized lipids in rats: effect of exogenous GSH.
The American journal of physiology 1992;263(5 Pt 1):G665-72.
1992: Tak Yee Aw; M W Williams; L Gray
Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: role of mucosal GSH.
The American journal of physiology 1992;262(1 Pt 1):G99-106.