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Isao Ishikawa

Research Profile

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Yuka Tsumanuma; Kaoru Washio; Azusa Yamada; Masayuki Yamato; T Yoshida; Konghua Lin; Takahiro Ohno; Teruo Okano; Ryo Takagi; Isao Ishikawa; Takanori Iwata; Yuichi Izumi
Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model.
Keiko Tanaka; K Iwasaki; Karine El Feghali; Motohiro Komaki; Isao Ishikawa; Yuichi Izumi
Comparison of characteristics of periodontal ligament cells obtained from outgrowth and enzyme-digested culture methods.
Fumihiko Akiyama; Akira Aoki; Mako Miura-Uchiyama; Katia M Sasaki; Shizuko Ichinose; Makoto Umeda; Isao Ishikawa; Yuichi Izumi
In vitro studies of the ablation mechanism of periodontopathic bacteria and decontamination effect on periodontally diseased root surfaces by erbium:yttrium-aluminum-garnet laser.

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All Publications

2011: Yuka Tsumanuma; Kaoru Washio; Azusa Yamada; Masayuki Yamato; T Yoshida; Konghua Lin; Takahiro Ohno; Teruo Okano; Ryo Takagi; Isao Ishikawa; Takanori Iwata; Yuichi Izumi
Comparison of different tissue-derived stem cell sheets for periodontal regeneration in a canine 1-wall defect model.
Biomaterials 2011;32(25):5819-25.
2011: Keiko Tanaka; K Iwasaki; Karine El Feghali; Motohiro Komaki; Isao Ishikawa; Yuichi Izumi
Comparison of characteristics of periodontal ligament cells obtained from outgrowth and enzyme-digested culture methods.
Archives of oral biology 2011;56(4):380-8.
2011: Fumihiko Akiyama; Akira Aoki; Mako Miura-Uchiyama; Katia M Sasaki; Shizuko Ichinose; Makoto Umeda; Isao Ishikawa; Yuichi Izumi
In vitro studies of the ablation mechanism of periodontopathic bacteria and decontamination effect on periodontally diseased root surfaces by erbium:yttrium-aluminum-garnet laser.
Lasers in medical science 2011;26(2):193-204.
2010: Verica Aleksic; Akira Aoki; Kengo Iwasaki; Aristeo Atsushi Takasaki; Chen-Ying Wang; Yoshimitsu Abiko; Isao Ishikawa; Yuichi Izumi
Low-level Er:YAG laser irradiation enhances osteoblast proliferation through activation of MAPK/ERK.
Lasers in medical science 2010;25(4):559-69.
2009: Toru Eguro; Akira Aoki; Toru Maeda; Aristeo Atsushi Takasaki; Mitsuru Hasegawa; Masaaki Ogawa; Takanori Suzuki; Kazuaki Yonemoto; Isao Ishikawa; Yuichi Izumi; Ichiroh Katsuumi
Energy output reduction and surface alteration of quartz and sapphire tips following Er:YAG laser contact irradiation for tooth enamel ablation.
Lasers in surgery and medicine 2009;41(8):595-604.
2009: I Sato; T Akizuki; Shigeru Oda; H Tsuchioka; C Hayashi; Aristeo Atsushi Takasaki; Koji Mizutani; N Kawakatsu; A Kinoshita; Isao Ishikawa; Y Izumi
Histological evaluation of alveolar ridge augmentation using injectable calcium phosphate bone cement in dogs.
Journal of oral rehabilitation 2009;36(10):762-9.
2009: T Suda; Toshiyuki Nagasawa; Nawarat Wara-aswapati; Hiroaki Kobayashi; K Iwasaki; Reiko Yashiro; Doosadee Hormdee; Hiroshi Nitta; Isao Ishikawa; Y Izumi
Regulatory roles of beta-catenin and AP-1 on osteoprotegerin production in interleukin-1alpha-stimulated periodontal ligament cells.
Oral microbiology and immunology 2009;24(5):384-9.
2009: Yi-Wen Chen; Toshiyuki Nagasawa; Nawarat Wara-aswapati; Yuka Ushida; Dongqing Wang; Yasuo Takeuchi; Hiroaki Kobayashi; Makoto Umeda; Yoshinori Inoue; Takehisa Iwai; Isao Ishikawa; Yuichi Izumi
Association between periodontitis and anti-cardiolipin antibodies in Buerger disease.
Journal of clinical periodontology 2009;36(10):830-5.
2009: K Feghali; K Iwasaki; Keiichi Tanaka; Motohiro Komaki; M Machigashira; Isao Ishikawa; Y Izumi
Human gingival fibroblasts release high-mobility group box-1 protein through active and passive pathways.
Oral microbiology and immunology 2009;24(4):292-8.
2009: Nawarat Wara-aswapati; Waranuch Pitiphat; L Chanchaimongkon; Suwimol Taweechaisupapong; J A Boch; Isao Ishikawa
Red bacterial complex is associated with the severity of chronic periodontitis in a Thai population.
Oral diseases 2009;15(5):354-9.
2009: Y Bando; Kazuyuki Noguchi; Hiroaki Kobayashi; N Yoshida; Isao Ishikawa; Y Izumi
Cyclooxygenase-2-derived prostaglandin E2 is involved in vascular endothelial growth factor production in interleukin-1alpha-stimulated human periodontal ligament cells.
Journal of periodontal research 2009;44(3):395-401.
2009: S Katagiri; H Nitta; T Nagasawa; Isao Uchimura; Hajime Izumiyama; K Inagaki; T Kikuchi; T Noguchi; M Kanazawa; A Matsuo; H Chiba; Noriaki Nakamura; N Kanamura; S Inoue; Isao Ishikawa; Y Izumi
Multi-center intervention study on glycohemoglobin (HbA1c) and serum, high-sensitivity CRP (hs-CRP) after local anti-infectious periodontal treatment in type 2 diabetic patients with periodontal disease.
Diabetes research and clinical practice 2009;83(3):308-15.
2009: Toshiaki Yoshino; Akira Aoki; Shigeru Oda; Aristeo Atsushi Takasaki; Koji Mizutani; Katia Miyuki Sasaki; A Kinoshita; Hisashi Watanabe; Isao Ishikawa; Yuichi Izumi
Long-term histologic analysis of bone tissue alteration and healing following Er:YAG laser irradiation compared to electrosurgery.
Journal of periodontology 2009;80(1):82-92.
2008: Mara Gomez Flores; Reiko Yashiro; Kaoru Washio; Masayuki Yamato; Teruo Okano; Isao Ishikawa
Periodontal ligament cell sheet promotes periodontal regeneration in athymic rats.
Journal of clinical periodontology 2008;35(12):1066-72.
2008: Yuka Ushida; Geena Koshy; Yoko Kawashima; Makoto Kiji; Makoto Umeda; Hiroshi Nitta; Toshiyuki Nagasawa; Isao Ishikawa; Yuichi Izumi
Changes in serum interleukin-6, C-reactive protein and thrombomodulin levels under periodontal ultrasonic debridement.
Journal of clinical periodontology 2008;35(11):969-75.
2008: N Kawakatsu; Shigeru Oda; A Kinoshita; S Kikuchi; H Tsuchioka; T Akizuki; C Hayashi; S Kokubo; Isao Ishikawa; Y Izumi
Effect of rhBMP-2 with PLGA/gelatin sponge type (PGS) carrier on alveolar ridge augmentation in dogs.
Journal of oral rehabilitation 2008;35(9):647-55.
2008: M Gomez Flores; M Hasegawa; Masayuki Yamato; R Takagi; Teruo Okano; Isao Ishikawa
Cementum-periodontal ligament complex regeneration using the cell sheet technique.
Journal of periodontal research 2008;43(3):364-71.
2008: Hiroaki Maruyama; Akira Aoki; Katia Miyuki Sasaki; Aristeo Atsushi Takasaki; Kengo Iwasaki; Shizuko Ichinose; Shigeru Oda; Isao Ishikawa; Yuichi Izumi
The effect of chemical and/or mechanical conditioning on the Er:YAG laser-treated root cementum: analysis of surface morphology and periodontal ligament fibroblast attachment.
Lasers in surgery and medicine 2008;40(3):211-22.
2008: Isao Ishikawa; Akira Aoki; Aristeo Atsushi Takasaki
Clinical application of erbium:YAG laser in periodontology.
Journal of the International Academy of Periodontology 2008;10(1):22-30.
2007: Tomohiko Gunji; Yoshihiro Onouchi; Toshiyuki Nagasawa; Sayaka Katagiri; Hisashi Watanabe; Hiroaki Kobayashi; Shinichi Arakawa; Kazuyuki Noguchi; Akira Hata; Yuichi Izumi; Isao Ishikawa
Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese.
Biochemical and biophysical research communications 2007;364(1):7-13.
2007: E R Leon; K Iwasaki; Motohiro Komaki; T Kojima; Isao Ishikawa
Osteogenic effect of interleukin-11 and synergism with ascorbic acid in human periodontal ligament cells.
Journal of periodontal research 2007;42(6):527-35.
2007: Aristeo Atsushi Takasaki; Akira Aoki; Koji Mizutani; Shigenari Kikuchi; Shigeru Oda; Isao Ishikawa
Er:YAG laser therapy for peri-implant infection: a histological study.
Lasers in medical science 2007;22(3):143-57.
2007: Makoto Kiji; Toshiyuki Nagasawa; Doosadee Hormdee; Reiko Yashiro; Hiroaki Kobayashi; Kazuyuki Noguchi; Hiroshi Nitta; Y Izumi; Isao Ishikawa
Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide.
Clinical and experimental immunology 2007;149(2):327-34.
2007: Kaoru Washio-Oikawa; Takahisa Nakamura; Michihiko Usui; Mitsuhiro Yoneda; Yoichi Ezura; Isao Ishikawa; Kazuhisa Nakashima; Tetsuo Noda; Tadashi Yamamoto; Masaki Noda
Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(8):1217-23.
2007: K Thiha; Yasuo Takeuchi; Makoto Umeda; Yi Huang; M Ohnishi; Isao Ishikawa
Identification of periodontopathic bacteria in gingival tissue of Japanese periodontitis patients.
Oral microbiology and immunology 2007;22(3):201-7.
2007: Tomoe Fukui; Hiroaki Kobayashi; Urara Hasegawa; Toshiyuki Nagasawa; Kazunari Akiyoshi; Isao Ishikawa
Intracellular delivery of nanogel-quantum dot hybrid nanoparticles into human periodontal ligament cells.
Drug metabolism letters 2007;1(2):131-5.
2007: Atsushi Miyata; Otto Baba; Tsuyoshi Oda; Isao Ishikawa; Yoshiro Takano
Diverse effects of c-src deficiency on molar tooth development and eruption in mice.
Archives of histology and cytology 2007;70(1):63-78.
2007: Kaori Mimori; Motohiro Komaki; Kengo Iwasaki; Isao Ishikawa
Extracellular signal-regulated kinase 1/2 is involved in ascorbic acid-induced osteoblastic differentiation in periodontal ligament cells.
Journal of periodontology 2007;78(2):328-34.
2007: Kazuyuki Noguchi; Isao Ishikawa
The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal disease.
Periodontology 2000 2007;43():85-101.
2007: Toshiyuki Nagasawa; Makoto Kiji; Reiko Yashiro; Doosadee Hormdee; He Lu; Melanie Kunze; Tomonari Suda; Geena Koshy; Hiroaki Kobayashi; Shigeru Oda; Hiroshi Nitta; Isao Ishikawa
Roles of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin in periodontal health and disease.
Periodontology 2000 2007;43():65-84.
2007: Isao Ishikawa
Host responses in periodontal diseases: a preview.
Periodontology 2000 2007;43():9-13.
2006: Yasuo Takeuchi; M Aramaki; Toshiyuki Nagasawa; Makoto Umeda; Shigeru Oda; Isao Ishikawa
Immunoglobulin G subclass antibody profiles in Porphyromonas gingivalis-associated aggressive and chronic periodontitis patients.
Oral microbiology and immunology 2006;21(5):314-8.
2006: Kaoru Washio-Oikawa; Takahisa Nakamura; Michihiko Usui; Mitsuhiro Yoneda; Yoichi Ezura; Isao Ishikawa; Kazuhisa Nakashima; Tadashi Yamamoto; Masaki Noda
Expression analysis of LacZ gene placed in the locus of Cnot7 exhibits its activity in osteoblasts in vivo and in mineralized nodules in vitro.
Journal of cellular biochemistry 2006;99(2):538-44.
2006: Dongqing Wang; Geena Koshy; Toshiyuki Nagasawa; Yoko Kawashima; Makoto Kiji; Hiroshi Nitta; Shigeru Oda; Isao Ishikawa
Antibody response after single-visit full-mouth ultrasonic debridement versus quadrant-wise therapy.
Journal of clinical periodontology 2006;33(9):632-8.
2006: K Nagatomo; Motohiro Komaki; Ichiro Sekiya; Yusuke Sakaguchi; Kazuyuki Noguchi; Shigeru Oda; Takeshi Muneta; Isao Ishikawa
Stem cell properties of human periodontal ligament cells.
Journal of periodontal research 2006;41(4):303-10.
2006: Chie Hayashi; Atsuhiro Kinoshita; Shigeru Oda; Koji Mizutani; Yoshinori Shirakata; Isao Ishikawa
Injectable calcium phosphate bone cement provides favorable space and a scaffold for periodontal regeneration in dogs.
Journal of periodontology 2006;77(6):940-6.
2006: Koji Mizutani; Akira Aoki; Aristeo Atsushi Takasaki; Atsuhiro Kinoshita; Chie Hayashi; Shigeru Oda; Isao Ishikawa
Periodontal tissue healing following flap surgery using an Er:YAG laser in dogs.
Lasers in surgery and medicine 2006;38(4):314-24.
2006: Reiko Yashiro; Toshiyuki Nagasawa; Makoto Kiji; Doosadee Hormdee; Hiroaki Kobayashi; Geena Koshy; Hiroshi Nitta; Isao Ishikawa
Transforming growth factor-beta stimulates interleukin-11 production by human periodontal ligament and gingival fibroblasts.
Journal of clinical periodontology 2006;33(3):165-71.
2005: Doosadee Hormdee; Toshiyuki Nagasawa; Makoto Kiji; Reiko Yashiro; Hiroaki Kobayashi; Geena Koshy; Kazuyuki Noguchi; Hiroshi Nitta; Isao Ishikawa
Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts.
Clinical and experimental immunology 2005;142(3):490-7.
2005: Geena Koshy; Yoko Kawashima; Makoto Kiji; Hiroshi Nitta; Makoto Umeda; Toshiyuki Nagasawa; Isao Ishikawa
Effects of single-visit full-mouth ultrasonic debridement versus quadrant-wise ultrasonic debridement.
Journal of clinical periodontology 2005;32(7):734-43.
2005: Mingming Yan; Kazuyuki Noguchi; S M P M Ruwanpura; Isao Ishikawa
Cyclooxygenase-2-dependent prostaglandin (PG) E2 downregulates matrix metalloproteinase-3 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells stimulated with interleukin-1alpha.
Journal of periodontology 2005;76(6):929-35.
2005: Tatsuya Akizuki; Shigeru Oda; Motohiro Komaki; Hiroaki Tsuchioka; Noriko Kawakatsu; Akihiko Kikuchi; Masayuki Yamato; Teruo Okano; Isao Ishikawa
Application of periodontal ligament cell sheet for periodontal regeneration: a pilot study in beagle dogs.
Journal of periodontal research 2005;40(3):245-51.
2005: D Wang; Yoko Kawashima; Toshiyuki Nagasawa; Yasuo Takeuchi; T Kojima; Makoto Umeda; Shigeru Oda; Isao Ishikawa
Elevated serum IgG titer and avidity to Actinobacillus actinomycetemcomitans serotype c in Japanese periodontitis patients.
Oral microbiology and immunology 2005;20(3):172-9.
2005: Rubia A Dias; Shunichi Shibata; Mariko Hashimoto-Uoshima; Katarzyna A Podyma-Inoue; Isao Ishikawa; Masaki Yanagishita
Syndecan-1 expression during the formation of junctional epithelium.
Journal of periodontology 2005;76(5):696-704.
2005: Kazuyuki Noguchi; M Maeda; S M P M Ruwanpura; Isao Ishikawa
Prostaglandin E2 (PGE2) downregulates interleukin (IL)-1alpha-induced IL-6 production via EP2/EP4 subtypes of PGE2 receptors in human periodontal ligament cells.
Oral diseases 2005;11(3):157-62.
2005: Amir Pourzarandian; Hisashi Watanabe; S M P M Ruwanpura; Akira Aoki; Kazuyuki Noguchi; Isao Ishikawa
Er:YAG laser irradiation increases prostaglandin E production via the induction of cyclooxygenase-2 mRNA in human gingival fibroblasts.
Journal of periodontal research 2005;40(2):182-6.
2005: Masateru Hasegawa; Masayuki Yamato; Akihiko Kikuchi; Teruo Okano; Isao Ishikawa
Human periodontal ligament cell sheets can regenerate periodontal ligament tissue in an athymic rat model.
Tissue engineering 2005;11(3-4):469-78.
2005: Hiroshi Nitta; Nawarat Wara-aswapati; Jinda Lertsirivorakul; Tsutomu Nakamura; Matsuo Yamamoto; Yuichi Izumi; Toshiaki Nakamura; Isao Ishikawa
A novel mutation of the cathepsin C gene in a thai family with Papillon-Lefevre syndrome.
Journal of periodontology 2005;76(3):492-6.
2005: Hisashi Watanabe; Hiroyuki Takinami; Masae Goseki-Sone; Hajime Orimo; Ryoko Hamatani; Isao Ishikawa
Characterization of the mutant (A115V) tissue-nonspecific alkaline phosphatase gene from adult-type hypophosphatasia.
Biochemical and biophysical research communications 2005;327(1):124-9.
2005: Amir Pourzarandian; Hisashi Watanabe; S M P M Ruwanpura; Akira Aoki; Isao Ishikawa
Effect of low-level Er:YAG laser irradiation on cultured human gingival fibroblasts.
Journal of periodontology 2005;76(2):187-93.
2005: Kazuyuki Noguchi; S M P M Ruwanpura; M Yan; N Yoshida; Isao Ishikawa
Down-regulation of interleukin-1alpha-induced matrix metalloproteinase-13 expression via EP1 receptors by prostaglandin E2 in human periodontal ligament cells.
Oral microbiology and immunology 2005;20(1):56-9.
2005: Chiyu Kato; Takehisa Kojima; Motohiro Komaki; Kaori Mimori; Wagner R Duarte; Keizo Takenaga; Isao Ishikawa
S100A4 inhibition by RNAi up-regulates osteoblast related genes in periodontal ligament cells.
Biochemical and biophysical research communications 2005;326(1):147-53.
2004: Makoto Umeda; Zenzo Miwa; Yasuo Takeuchi; Motoko Ishizuka; Yi Huang; Kazuyuki Noguchi; Mitsuro Tanaka; Yuzo Takagi; Isao Ishikawa
The distribution of periodontopathic bacteria among Japanese children and their parents.
Journal of periodontal research 2004;39(6):398-404.
2004: Amir Pourzarandian; Hisashi Watanabe; Akira Aoki; Shizuko Ichinose; Katia M Sasaki; Hiroshi Nitta; Isao Ishikawa
Histological and TEM examination of early stages of bone healing after Er:YAG laser irradiation.
Photomedicine and laser surgery 2004;22(4):342-50.
2004: Isao Ishikawa; Akira Aoki; Aristeo Atsushi Takasaki
Potential applications of Erbium:YAG laser in periodontics.
Journal of periodontal research 2004;39(4):275-85.
2004: Michihiko Usui; Yutaka Yoshida; Kunikazu Tsuji; Kaoru Oikawa; Kohei Miyazono; Isao Ishikawa; Tadashi Yamamoto; Akira Nifuji; Masaki Noda
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(17):6653-8.
2004: Tsutomu Nakamura; Hiroshi Nitta; Isao Ishikawa
Effect of low dose Actinobacillus actinomycetemcomitans lipopolysaccharide pretreatment on cytokine production by human whole blood.
Journal of periodontal research 2004;39(2):129-35.
2004: Hiroyuki Takinami; Masae Goseki-Sone; Hisashi Watanabe; Hajime Orimo; Ryoko Hamatani; Mariko Fukushi-Irie; Isao Ishikawa
The mutant (F310L and V365I) tissue-nonspecific alkaline phosphatase gene from hypophosphatasia.
Journal of medical and dental sciences 2004;51(1):67-74.
2004: S M P M Ruwanpura; Kazuyuki Noguchi; Isao Ishikawa
Prostaglandin E2 regulates interleukin-1beta-induced matrix metalloproteinase-3 production in human gingival fibroblasts.
Journal of dental research 2004;83(3):260-5.
2003: Yasuo Takeuchi; Makoto Umeda; Motoko Ishizuka; Yi Huang; Isao Ishikawa
Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population.
Journal of periodontology 2003;74(10):1460-9.
2003: Yi Huang; Makoto Umeda; Yasuo Takeuchi; M Ishizuka; K Yano-Higuchi; Isao Ishikawa
Distribution of Bacteroides forsythus genotypes in a Japanese periodontitis population.
Oral microbiology and immunology 2003;18(4):208-14.
2003: Yuya Murakami; Takehisa Kojima; Toshiyuki Nagasawa; Hiroaki Kobayashi; Isao Ishikawa
Novel isolation of alkaline phosphatase-positive subpopulation from periodontal ligament fibroblasts.
Journal of periodontology 2003;74(6):780-6.
2003: K Iwasaki; Kazuyuki Noguchi; H Endo; H Kondo; Isao Ishikawa
Prostaglandin E2 downregulates interleukin-12 production through EP4 receptors in human monocytes stimulated with lipopolysaccharide from Actinobacillus actinomycetemcomitans and interferon-gamma.
Oral microbiology and immunology 2003;18(3):150-5.
2003: Wagner R Duarte; Tatsuya Shibata; Keizo Takenaga; Etsuko Takahashi; Kaori Kubota; Keiichi Ohya; Isao Ishikawa; Mitsuo Yamauchi; Shohei Kasugai
S100A4: a novel negative regulator of mineralization and osteoblast differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2003;18(3):493-501.
2003: Tomoko Matsuyama; Akira Aoki; Shigeru Oda; Takayuki Yoneyama; Isao Ishikawa
Effects of the Er:YAG laser irradiation on titanium implant materials and contaminated implant abutment surfaces.
Journal of clinical laser medicine & surgery 2003;21(1):7-17.
2003: Isao Ishikawa; Katia Miyuki Sasaki; Akira Aoki; Hisashi Watanabe
Effects of Er:YAG laser on periodontal therapy.
Journal of the International Academy of Periodontology 2003;5(1):23-8.
2003: Makoto Umeda; Hiroaki Kobayashi; Yasuo Takeuchi; Joichiro Hayashi; Yoko Morotome-Hayashi; Kazuko Yano; Akira Aoki; Toshifumi Ohkusa; Isao Ishikawa
High prevalence of Helicobacter pylori detected by PCR in the oral cavities of periodontitis patients.
Journal of periodontology 2003;74(1):129-34.
2002: Hisashi Watanabe; Masae Goseki-Sone; Hajime Orimo; Ryoko Hamatani; Hiroyuki Takinami; Isao Ishikawa
Function of mutant (G1144A) tissue-nonspecific ALP gene from hypophosphatasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(11):1945-8.
2002: Toshiyuki Nagasawa; Hiroaki Kobayashi; Makoto Kiji; M Aramaki; R Mahanonda; T Kojima; Y Murakami; M Saito; Y Morotome; Isao Ishikawa
LPS-stimulated human gingival fibroblasts inhibit the differentiation of monocytes into osteoclasts through the production of osteoprotegerin.
Clinical and experimental immunology 2002;130(2):338-44.
2002: K Kubota; S Iseki; S Kuroda; Shinichiro Oida; Tadahiro Iimura; Wagner R Duarte; Keiichi Ohya; Isao Ishikawa; Shohei Kasugai
Synergistic effect of fibroblast growth factor-4 in ectopic bone formation induced by bone morphogenetic protein-2.
Bone 2002;31(4):465-71.
2002: Yoshinori Shirakata; Shigeru Oda; Atsuhiro Kinoshita; Shigenari Kikuchi; Hiroaki Tsuchioka; Isao Ishikawa
Histocompatible healing of periodontal defects after application of an injectable calcium phosphate bone cement. A preliminary study in dogs.
Journal of periodontology 2002;73(9):1043-53.
2002: Yoko Kawashima; Isao Ishikawa
Simple and rapid detection of serum antibody to periodontopathic bacteria by dot blotting.
Journal of periodontal research 2002;37(3):223-9.
2002: Rangsini Mahanonda; Noppadol Sa-Ard-Iam; Kosol Yongvanitchit; Mahisorn Wisetchang; Isao Ishikawa; Toshiyuki Nagasawa; Douglas S Walsh; Sathit Pichyangkul
Upregulation of co-stimulatory molecule expression and dendritic cell marker (CD83) on B cells in periodontal disease.
Journal of periodontal research 2002;37(3):177-83.
2002: T Iwata; Y Morotome; T Tanabe; Makoto Fukae; Isao Ishikawa; Shinichiro Oida
Noggin blocks osteoinductive activity of porcine enamel extracts.
Journal of dental research 2002;81(6):387-91.
2002: Katia M Sasaki; Akira Aoki; Shizuko Ichinose; Toshiaki Yoshino; Sachiko Yamada; Isao Ishikawa
Scanning electron microscopy and Fourier transformed infrared spectroscopy analysis of bone removal using Er:YAG and CO2 lasers.
Journal of periodontology 2002;73(6):643-52.
2002: K M Sasaki; Akira Aoki; H Masuno; S Ichinose; S Yamada; Isao Ishikawa
Compositional analysis of root cementum and dentin after Er:YAG laser irradiation compared with CO2 lased and intact roots using Fourier transformed infrared spectroscopy.
Journal of periodontal research 2002;37(1):50-9.
2002: Mariko Hashimoto-Uoshima; K Noguchi; M Suzuki; A Murata; Masaki Yanagishita; Isao Ishikawa
Effects of interleukin-4 on proteoglycan accumulation in human gingival fibroblasts.
Journal of periodontal research 2002;37(1):42-9.
2002: Kazuyuki Noguchi; Miki Shitashige; Hirahito Endo; Hirobumi Kondo; Isao Ishikawa
Binary regulation of interleukin (IL)-6 production by EP1 and EP2/EP4 subtypes of PGE2 receptors in IL-1beta-stimulated human gingival fibroblasts.
Journal of periodontal research 2002;37(1):29-36.
2002: Katia M Sasaki; Akira Aoki; Shizuko Ichinose; Isao Ishikawa
Ultrastructural analysis of bone tissue irradiated by Er:YAG Laser.
Lasers in surgery and medicine 2002;31(5):322-32.
2002: Katia M Sasaki; Akira Aoki; Shizuko Ichinose; Isao Ishikawa
Morphological analysis of cementum and root dentin after Er:YAG laser irradiation.
Lasers in surgery and medicine 2002;31(2):79-85.
2001: Nawarat Wara-aswapati; J Lertsirivorakul; T Nagasawa; Y Kawashima; Isao Ishikawa
Papillon-Lefèvre syndrome: serum immunoglobulin G (IgG) subclass antibody response to periodontopathic bacteria. A case report.
Journal of periodontology 2001;72(12):1747-54.
2001: Hisashi Watanabe; M Hashimoto-Uoshima; Masae Goseki-Sone; Hajime Orimo; Isao Ishikawa
A novel point mutation (C571T) in the tissue-non-specific alkaline phosphatase gene in a case of adult-type hypophosphatasia.
Oral diseases 2001;7(6):331-5.
2001: Yasuo Takeuchi; Makoto Umeda; M Sakamoto; Y Benno; Yi Huang; Isao Ishikawa
Treponema socranskii, Treponema denticola, and Porphyromonas gingivalis are associated with severity of periodontal tissue destruction.
Journal of periodontology 2001;72(10):1354-63.
2001: Kazuyuki Noguchi; Y Tominaga; K Matsushita; Y Izumi; Hirahito Endo; H Kondo; Isao Ishikawa
Upregulation of matrix metalloproteinase-1 production by prostaglandin F2alpha in human gingival fibroblasts.
Journal of periodontal research 2001;36(5):334-9.
2001: K Noguchi; H Endo; H Kondo; Isao Ishikawa
Prostaglandin F2alpha upregulates interleukin-6 production in human gingival fibroblasts.
Journal of periodontal research 2001;36(2):80-7.
2001: K Noguchi; M Shitashige; H Endo; H Kondo; Y Yotsumoto; Y Izumi; Hiroshi Nitta; Isao Ishikawa
Involvement of cyclooxygenase-2 in serum-induced prostaglandin production by human oral gingival epithelial cells.
Journal of periodontal research 2001;36(2):124-30.
2001: Kazuyuki Noguchi; K Iwasaki; Miki Shitashige; Makoto Umeda; Y Izumi; Sei-Itsu Murota; Isao Ishikawa
Downregulation of lipopolysaccharide-induced intercellular adhesion molecule-1 expression via EP2/EP4 receptors by prostaglandin E2 in human fibroblasts.
Inflammation 2001;25(2):75-81.
2000: Kazuyuki Noguchi; K Iwasaki; M Shitashige; H Endo; H Kondo; Isao Ishikawa
Cyclooxygenase-2-dependent prostaglandin E2 down-regulates intercellular adhesion molecule-1 expression via EP2/EP4 receptors in interleukin-1beta-stimulated human gingival fibroblasts.
Journal of dental research 2000;79(12):1955-61.
2000: Hiroaki Kobayashi; Toshiyuki Nagasawa; M Aramaki; R Mahanonda; Isao Ishikawa
Individual diversities in interferon gamma production by human peripheral blood mononuclear cells stimulated with periodontopathic bacteria.
Journal of periodontal research 2000;35(6):319-28.
2000: K Noguchi; K Iwasaki; H Endo; H Kondo; M Shitashige; Isao Ishikawa
Prostaglandins E2 and I2 downregulate tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human oral gingival epithelial cells.
Oral microbiology and immunology 2000;15(5):299-304.
2000: K Noguchi; M Yanai; M Shitashige; T Nishihara; Isao Ishikawa
Cyclooxygenase-2-dependent prostaglandin production by peripheral blood monocytes stimulated with lipopolysaccharides isolated from periodontopathogenic bacteria.
Journal of periodontology 2000;71(10):1575-82.
2000: Akira Aoki; M Miura; F Akiyama; N Nakagawa; J Tanaka; Shigeru Oda; Hisashi Watanabe; Isao Ishikawa
In vitro evaluation of Er:YAG laser scaling of subgingival calculus in comparison with ultrasonic scaling.
Journal of periodontal research 2000;35(5):266-77.
2000: Hiroshi Nitta; H Kato; Makoto Umeda; S Kuwata; Isao Ishikawa
Papillon-Lefèvre syndrome: analysis of HLA antigens.
Oral diseases 2000;6(5):278-81.
2000: K Yano-Higuchi; N Takamatsu; T He; Makoto Umeda; Isao Ishikawa
Prevalence of Bacteroides forsythus, Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans in subgingival microflora of Japanese patients with adult and rapidly progressive periodontitis.
Journal of clinical periodontology 2000;27(8):597-602.
2000: H Yazawa; Y Takano; Isao Ishikawa
Time-related changes of developing enamel crystals after exposure to the tissue fluid in vivo: analysis of a subcutaneously implanted rat incisor.
Archives of histology and cytology 2000;63(2):169-79.
1999: K Noguchi; K Iwasaki; M Shitashige; Isao Ishikawa
Prostaglandin E2 receptors of the EP2 and EP4 subtypes downregulate tumor necrosis factor alpha-induced intercellular adhesion molecule-1 expression in human gingival fibroblasts.
Journal of periodontal research 1999;34(8):478-85.
1999: T He; T Nishihara; D R Demuth; Isao Ishikawa
A novel insertion sequence increases the expression of leukotoxicity in Actinobacillus actinomycetemcomitans clinical isolates.
Journal of periodontology 1999;70(11):1261-8.
1999: K Noguchi; K Iwasaki; Miki Shitashige; S Murato; Isao Ishikawa
Prostaglandin E2 downregulates interferon-gamma-induced intercellular adhesion molecule-1 expression via EP2 receptors in human gingival fibroblasts.
Inflammation 1999;23(5):481-93.
1999: T Higuchi; A Kinoshita; K Takahashi; S Oda; Isao Ishikawa
Bone regeneration by recombinant human bone morphogenetic protein-2 in rat mandibular defects. An experimental model of defect filling.
Journal of periodontology 1999;70(9):1026-31.
1999: K Noguchi; M Shitashige; Isao Ishikawa
Involvement of cyclooxygenase-2 in interleukin-1alpha-induced prostaglandin production by human periodontal ligament cells.
Journal of periodontology 1999;70(8):902-8.
1999: K Noguchi; K Iwasaki; Isao Ishikawa
Prostaglandin F2 alpha upregulates intercellular adhesion molecule-1 expression in human gingival fibroblasts.
Journal of periodontal research 1999;34(5):277-81.
1999: T Masaka; J Hayashi; Isao Ishikawa
Soluble CD14-dependent intercellular adhesion molecular-1 induction by Porphyromonas gingivalis lipopolysaccharide in human gingival fibroblasts.
Journal of periodontology 1999;70(7):772-8.
1999: Hisashi Watanabe; Masae Goseki-Sone; Tadahiro Iimura; Shinichiro Oida; Hajime Orimo; Isao Ishikawa
Molecular diagnosis of hypophosphatasia with severe periodontitis.
Journal of periodontology 1999;70(6):688-91.
1999: N Takamatsu; K Yano; T He; Makoto Umeda; Isao Ishikawa
Effect of initial periodontal therapy on the frequency of detecting Bacteroides forsythus, Porphyromonas gingivalis, and Actinobacillus actinomycetemcomitans.
Journal of periodontology 1999;70(6):574-80.
1999: Wagner R Duarte; Tadahiro Iimura; Keizo Takenaga; Keiichi Ohya; Isao Ishikawa; Shohei Kasugai
Extracellular role of S100A4 calcium-binding protein in the periodontal ligament.
Biochemical and biophysical research communications 1999;255(2):416-20.
1999: K Iwasaki; K Noguchi; Isao Ishikawa
Prostaglandin E2 and I2 regulate intercellular adhesion molecule-1 expression in interleukin-1 beta-stimulated human gingival fibroblasts.
Journal of periodontal research 1999;34(2):97-104.
1999: K Noguchi; Miki Shitashige; H Watanabe; Sei-Itsu Murota; Isao Ishikawa
Interleukin-4 and interferon-gamma inhibit prostaglandin production by interleukin-1beta-stimulated human periodontal ligament fibroblasts.
Inflammation 1999;23(1):1-13.
1999: J Hayashi; T Masaka; Isao Ishikawa
Increased levels of soluble CD14 in sera of periodontitis patients.
Infection and immunity 1999;67(1):417-20.
1998: S M San Miguel; Masae Goseki-Sone; E Sugiyama; Hisashi Watanabe; Masaki Yanagishita; Isao Ishikawa
The effects of retinoic acid on alkaline phosphatase activity and tissue-non-specific alkaline phosphatase gene expression in human periodontal ligament cells and gingival fibroblasts.
Journal of periodontal research 1998;33(7):428-33.
1998: Wagner R Duarte; Shohei Kasugai; Tadahiro Iimura; Shinichiro Oida; Keizo Takenaga; Keiichi Ohya; Isao Ishikawa
cDNA cloning of S100 calcium-binding proteins from bovine periodontal ligament and their expression in oral tissues.
Journal of dental research 1998;77(9):1694-9.
1998: K Bando; H Nitta; M Matsubara; Isao Ishikawa
Bone mineral density in periodontally healthy and edentulous postmenopausal women.
Annals of periodontology / the American Academy of Periodontology 1998;3(1):322-6.
1998: Isao Ishikawa; S Arakawa
Awareness of periodontal disease--the role of industry.
International dental journal 1998;48(3 Suppl 1):261-7.
1998: Y Morotome; Masae Goseki-Sone; Isao Ishikawa; Shinichiro Oida
Gene expression of growth and differentiation factors-5, -6, and -7 in developing bovine tooth at the root forming stage.
Biochemical and biophysical research communications 1998;244(1):85-90.
1998: T He; J Hayashi; M Yamamoto; Isao Ishikawa
Genotypic characterization of Actinobacillus actinomycetemcomitans isolated from periodontitis patients by arbitrarily primed polymerase chain reaction.
Journal of periodontology 1998;69(1):69-75.
1997: S Oda; A Kinoshita; T Higuchi; T Shizuya; Isao Ishikawa
Ectopic bone formation by biphasic calcium phosphate (BCP) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2).
Journal of medical and dental sciences 1997;44(3):53-62.
1997: Isao Ishikawa; K Nakashima; T Koseki; T Nagasawa; H Watanabe; S Arakawa; Hiroshi Nitta; T Nishihara
Induction of the immune response to periodontopathic bacteria and its role in the pathogenesis of periodontitis.
Periodontology 2000 1997;14():79-111.
1997: A Kinoshita; S Oda; K Takahashi; S Yokota; Isao Ishikawa
Periodontal regeneration by application of recombinant human bone morphogenetic protein-2 to horizontal circumferential defects created by experimental periodontitis in beagle dogs.
Journal of periodontology 1997;68(2):103-9.
1996: J Hayashi; T Masaka; I Saito; Isao Ishikawa
Soluble CD14 mediates lipopolysaccharide-induced intercellular adhesion molecule 1 expression in cultured human gingival fibroblasts.
Infection and immunity 1996;64(12):4946-51.
1996: K Yano; N Takamatsu; T He; M Umeda; Isao Ishikawa
[Evaluation of non radioactive DNA probe (Affirm DP) for detecting periodontopathic bacteria].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1996;63(3):482-8.
1996: S Oda; A Kinoshita; T Higuchi; T Shizuya; Isao Ishikawa
[Ectopic bone induction in recombinant human bone morphogenetic protein-2 (rhBMP-2) combined with biphasic calcium phosphate (BCP)].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1996;63(3):468-77.
1996: E A Boutsl; Takeyoshi Koseki; T Nishihara; Isao Ishikawa
Characterization of the immunodominant antigens of Porphyromonas gingivalis 381 in high-responder patients.
Oral microbiology and immunology 1996;11(4):236-41.
1996: Takeyoshi Koseki; Isao Ishikawa; E Boutsi; T He; Y Benno
Nutritional analysis and an enriched medium for fermentative treponemes isolated from subgingival plaque.
Oral microbiology and immunology 1996;11(3):166-71.
1996: Hisashi Watanabe; Isao Ishikawa; M Suzuki; K Hasegawa
Clinical assessments of the erbium:YAG laser for soft tissue surgery and scaling.
Journal of clinical laser medicine & surgery 1996;14(2):67-75.
1996: M Umeda; Y Tominaga; T He; K Yano; Hisashi Watanabe; Isao Ishikawa
Microbial flora in the acute phase of periodontitis and the effect of local administration of minocycline.
Journal of periodontology 1996;67(4):422-7.
1996: Isao Ishikawa; S Oda; J Hayashi; S Arakawa
Cervical cemental tears in older patients with adult periodontitis. Case reports.
Journal of periodontology 1996;67(1):15-20.
1995: Takeyoshi Koseki; Isao Ishikawa; M Umeda; Y Benno
Characterization of oral treponemes isolated from human periodontal pockets.
Oral microbiology and immunology 1995;10(5):271-7.
1995: T Nagasawa; H Nitta; Hisashi Watanabe; Isao Ishikawa
Reduced CD8+ peripheral blood T lymphocytes in rapidly progressive periodontitis.
Archives of oral biology 1995;40(7):605-8.
1995: M Horibe; Hisashi Watanabe; Isao Ishikawa
Effect of periodontal treatments on serum IgG antibody titers against periodontopathic bacteria.
Journal of clinical periodontology 1995;22(7):510-5.
1995: jose ricardo kina; N Yoshida; M Goseki; S Sasaki; Isao Ishikawa
Properties of alkaline phosphatase in the gingival crevicular fluid.
The Bulletin of Tokyo Medical and Dental University 1995;42(2):57-65.
1995: Y J Zhang; S Yasui; F Yoshimura; Isao Ishikawa
Multiple restriction fragment length polymorphism genotypes of Porphyromonas gingivalis in single periodontal pockets.
Oral microbiology and immunology 1995;10(2):125-8.
1994: A Aoki; Y Ando; Hisashi Watanabe; Isao Ishikawa
In vitro studies on laser scaling of subgingival calculus with an erbium:YAG laser.
Journal of periodontology 1994;65(12):1097-106.
1994: J Hayashi; I Saito; Isao Ishikawa; N Miyasaka
Effects of cytokines and periodontopathic bacteria on the leukocyte function-associated antigen 1/intercellular adhesion molecule 1 pathway in gingival fibroblasts in adult periodontitis.
Infection and immunity 1994;62(12):5205-12.
1994: Isao Ishikawa; M Umeda; N Laosrisin
Clinical, bacteriological, and immunological examinations and the treatment process of two Papillon-Lefèvre syndrome patients.
Journal of periodontology 1994;65(4):364-71.
1993: T Kojima; S Yasui; Isao Ishikawa
Distribution of Porphyromonas gingivalis in adult periodontitis patients.
Journal of periodontology 1993;64(12):1231-7.
1993: H Nitta; Y Kameyama; Isao Ishikawa
Unusual gingival enlargement with rapidly progressive periodontitis. Report of a case.
Journal of periodontology 1993;64(10):1008-12.
1993: S Hagiwara; M Iida; Isao Ishikawa
[Clinical and microbiological study concerning effects of scaling and root planing. 2. The effects of mechanical debridement until one year and of minocycline application topically].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1993;60(2):301-12.
1993: H Nitta; Isao Ishikawa
Analysis of the genetic control of antibody response to Actinobacillus actinomycetemcomitans by immunoblotting inbred strains of mice.
Oral microbiology and immunology 1993;8(3):141-5.
1993: Hisashi Watanabe; M Umeda; T Seki; Isao Ishikawa
Clinical and laboratory studies of severe periodontal disease in an adolescent associated with hypophosphatasia. A case report.
Journal of periodontology 1993;64(3):174-80.
1992: S Hagiwara; F Sato; E Boutsi; M Iida; T Seki; M Umeda; Isao Ishikawa
[Clinical and microbiological study of factors determining effective scaling and root planing].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1992;59(2):331-50.
1992: K Noguchi; Ikuo Morita; Isao Ishikawa; Sei-Itsu Murota
Time-dependent Increase of Platelet-activating Factor Acetylhydrolase in the Culture Medium of Mouse Calvaria.
Platelets 1992;3(1):23-7.
1991: H Nitta; W Soeda; M Horibe; H Ohno; K Rikimaru; M Takesue; S Enomoto; Y Kameyama; Isao Ishikawa
[Rapidly progressive periodontitis combined with plasma cell gingivitis: a case report].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1991;58(3):624-30.
1991: Hisashi Watanabe; M Iida; Y J Zhang; T Seki; Isao Ishikawa
[A case of severe periodontal disease in adolescence associated with hypophosphatasia].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1991;58(3):613-23.
1990: M Umeda; Y J Zhang; Takeyoshi Koseki; Isao Ishikawa
[Clinical, bacteriological, and immunological examination and treatment of two Papillon-Lefevre syndrome patients].
Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan 1990;57(3):430-40.
1990: S Arakawa; S Hata; Isao Ishikawa; N Tsuchida
Gene cloning of an Actinobacillus actinomycetemcomitans Y4 antigen which reacts with peripheral blood sera in patients with advanced destructive periodontitis.
Archives of oral biology 1990;35 Suppl():93S-96S.
1989: C J Lin; Isao Ishikawa
Effect of porous and dense hydroxyapatite implantation on periodontal tissue regeneration in monkeys.
The Bulletin of Tokyo Medical and Dental University 1989;36(1):1-11.
1988: K Noguchi; I Morita; Isao Ishikawa; S Murota
Impaired polymorphonuclear leukocyte 15-lipoxygenase activity in juvenile and rapidly progressive periodontitis.
Prostaglandins, leukotrienes, and essential fatty acids 1988;33(2):137-41.