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Koichiro Ishimori

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Koichi Sakamoto; Kyoko Shinzawa-Itoh; Takeshi Uchida; Shinya Yoshikawa; Mizue Imai; Masakatsu Kamiya; Keiichi Kawano; Koichiro Ishimori
NMR basis for interprotein electron transfer gating between cytochrome c and cytochrome c oxidase.
Haruto Ishikawa; Megumi Nakagaki; Ai Bamba; T Uchida; Hiroshi Hori; Mark R O'Brian; Kazuhiro Iwai; Koichiro Ishimori
Unusual heme binding in the bacterial iron response regulator protein: spectral characterization of heme binding to the heme regulatory motif.
Koichi Sakamoto; Masakatsu Kamiya; Takeshi Uchida; Keiichi Kawano; Koichiro Ishimori
Redox-controlled backbone dynamics of human cytochrome c revealed by 15N NMR relaxation measurements.

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2011: Koichi Sakamoto; Kyoko Shinzawa-Itoh; Takeshi Uchida; Shinya Yoshikawa; Mizue Imai; Masakatsu Kamiya; Keiichi Kawano; Koichiro Ishimori
NMR basis for interprotein electron transfer gating between cytochrome c and cytochrome c oxidase.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(30):12271-6.
2011: Haruto Ishikawa; Megumi Nakagaki; Ai Bamba; T Uchida; Hiroshi Hori; Mark R O'Brian; Kazuhiro Iwai; Koichiro Ishimori
Unusual heme binding in the bacterial iron response regulator protein: spectral characterization of heme binding to the heme regulatory motif.
Biochemistry 2011;50(6):1016-22.
2010: Koichi Sakamoto; Masakatsu Kamiya; Takeshi Uchida; Keiichi Kawano; Koichiro Ishimori
Redox-controlled backbone dynamics of human cytochrome c revealed by 15N NMR relaxation measurements.
Biochemical and biophysical research communications 2010;398(2):231-6.
2008: Takanori Uzawa; Chiaki Nishimura; Shuji Akiyama; Koichiro Ishimori; Satoshi Takahashi; H Jane Dyson; Peter Wright
Hierarchical folding mechanism of apomyoglobin revealed by ultra-fast H/D exchange coupled with 2D NMR.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(37):13859-64.
2008: Tetsunari Kimura; Akio Maeda; Shingo Nishiguchi; Koichiro Ishimori; Isao Morishima; Takashi Konno; Yuji Goto; Satoshi Takahashi
Dehydration of main-chain amides in the final folding step of single-chain monellin revealed by time-resolved infrared spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13391-6.
2007: Shizuo Ichimura; Takeshi Uchida; Shuhei Taniguchi; Shusuke Hira; Takehiko Tosha; Isao Morishima; Teizo Kitagawa; Koichiro Ishimori
Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2: compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue.
The Journal of biological chemistry 2007;282(22):16681-90.
2007: Chihiro Kitatsuji; Masaki Kurogochi; Shin-Ichiro Nishimura; Koichiro Ishimori; Keisuke Wakasugi
Molecular basis of guanine nucleotide dissociation inhibitor activity of human neuroglobin by chemical cross-linking and mass spectrometry.
Journal of molecular biology 2007;368(1):150-60.
2006: Takanori Uzawa; Tetsunari Kimura; Koichiro Ishimori; Isao Morishima; Toshitaka Matsui; Masao Ikeda-Saito; Satoshi Takahashi; Shuji Akiyama; Tetsuro Fujisawa
Time-resolved small-angle X-ray scattering investigation of the folding dynamics of heme oxygenase: implication of the scaling relationship for the submillisecond intermediates of protein folding.
Journal of molecular biology 2006;357(3):997-1008.
2006: Tetsunari Kimura; Koichi Sakamoto; Isao Morishima; Koichiro Ishimori
Dehydration in the folding of reduced cytochrome c revealed by the electron-transfer-triggered folding under high pressure.
Journal of the American Chemical Society 2006;128(3):670-1.
2005: Masato Shintaku; Koji Matsuura; Shiro Yoshioka; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Absence of a detectable intermediate in the compound I formation of horseradish peroxidase at ambient temperature.
The Journal of biological chemistry 2005;280(49):40934-8.
2005: Tetsunari Kimura; Shuji Akiyama; Takanori Uzawa; Koichiro Ishimori; Isao Morishima; Tetsuro Fujisawa; Satoshi Takahashi
Specifically collapsed intermediate in the early stage of the folding of ribonuclease A.
Journal of molecular biology 2005;350(2):349-62.
2005: Koji Matsuura; Shiro Yoshioka; Takehiko Tosha; Hiroshi Hori; Koichiro Ishimori; Teizo Kitagawa; Isao Morishima; Norio Kagawa; Michael R Waterman
Structural diversities of active site in clinical azole-bound forms between sterol 14alpha-demethylases (CYP51s) from human and Mycobacterium tuberculosis.
The Journal of biological chemistry 2005;280(10):9088-96.
2005: Furukawa Yoshiaki; Tadato Ban; Daizo Hamada; Koichiro Ishimori; Yuji Goto; Isao Morishima
Electron transfer reaction in a single protein molecule observed by total internal reflection fluorescence microscopy.
Journal of the American Chemical Society 2005;127(7):2098-103.
2005: Tetsunari Kimura; Takanori Uzawa; Koichiro Ishimori; Isao Morishima; Satoshi Takahashi; Takashi Konno; Shuji Akiyama; Tetsuro Fujisawa
Specific collapse followed by slow hydrogen-bond formation of beta-sheet in the folding of single-chain monellin.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(8):2748-53.
2004: Haruto Ishikawa; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Steric effects of isoleucine 107 on heme reorientation reaction in human myoglobin.
Biochemical and biophysical research communications 2004;324(3):1095-100.
2004: Koji Matsuura; Takehiko Tosha; Shiro Yoshioka; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Structural and functional characterization of "laboratory evolved" cytochrome P450cam mutants showing enhanced naphthalene oxygenation activity.
Biochemical and biophysical research communications 2004;323(4):1209-15.
2004: Takehiko Tosha; Shiro Yoshioka; Koichiro Ishimori; Isao Morishima
L358P mutation on cytochrome P450cam simulates structural changes upon putidaredoxin binding: the structural changes trigger electron transfer to oxy-P450cam from electron donors.
The Journal of biological chemistry 2004;279(41):42836-43.
2004: Shingo Nagano; Takehiko Tosha; Koichiro Ishimori; Isao Morishima; Thomas L Poulos
Crystal structure of the cytochrome p450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding.
The Journal of biological chemistry 2004;279(41):42844-9.
2004: Koji Matsuura; Shiro Yoshioka; Satoshi Takahashi; Koichiro Ishimori; Tatsushi Mogi; Hiroshi Hori; Isao Morishima
Dioxygen reduction by bo-type quinol oxidase from Escherichia coli studied by submillisecond-resolved freeze-quench EPR spectroscopy.
Biochemistry 2004;43(8):2288-96.
2004: Takayuki Inuzuka; Bo-Geon Yun; Haruto Ishikawa; Satoshi Takahashi; Hiroshi Hori; Robert L Matts; Koichiro Ishimori; Isao Morishima
Identification of crucial histidines for heme binding in the N-terminal domain of the heme-regulated eIF2alpha kinase.
The Journal of biological chemistry 2004;279(8):6778-82.
2004: Takanori Uzawa; Shuji Akiyama; Tetsunari Kimura; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima; Tetsuro Fujisawa
Collapse and search dynamics of apomyoglobin folding revealed by submillisecond observations of alpha-helical content and compactness.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(5):1171-6.
2003: Takehiko Tosha; Shiro Yoshioka; Satoshi Takahashi; Koichiro Ishimori; Hideo Shimada; Isao Morishima
NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes.
The Journal of biological chemistry 2003;278(41):39809-21.
2003: Koji Yamanaka; Haruto Ishikawa; Yuzuru Megumi; Fuminori Tokunaga; Masato Kanie; Tracey A Rouault; Isao Morishima; Nagahiro Minato; Koichiro Ishimori; Kazuhiro Iwai
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.
Nature cell biology 2003;5(4):336-40.
2003: Motomasa Tanaka; Koji Matsuura; Shiro Yoshioka; Satoshi Takahashi; Koichiro Ishimori; Hiroshi Hori; Isao Morishima
Activation of hydrogen peroxide in horseradish peroxidase occurs within approximately 200 micro s observed by a new freeze-quench device.
Biophysical journal 2003;84(3):1998-2004.
2002: Shiro Yoshioka; Takehiko Tosha; Satoshi Takahashi; Koichiro Ishimori; Hiroshi Hori; Isao Morishima
Roles of the proximal hydrogen bonding network in cytochrome P450cam-catalyzed oxygenation.
Journal of the American Chemical Society 2002;124(49):14571-9.
2002: Takehiko Tosha; Shiro Yoshioka; Hiroshi Hori; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Molecular mechanism of the electron transfer reaction in cytochrome P450(cam)--putidaredoxin: roles of glutamine 360 at the heme proximal site.
Biochemistry 2002;41(47):13883-93.
2002: Haruto Ishikawa; Bo-Geon Yun; Satoshi Takahashi; Hiroshi Hori; Robert L Matts; Koichiro Ishimori; Isao Morishima
NO-induced activation mechanism of the heme-regulated eIF2alpha kinase.
Journal of the American Chemical Society 2002;124(46):13696-7.
2002: Tetsunari Kimura; Satoshi Takahashi; Shuji Akiyama; Takanori Uzawa; Koichiro Ishimori; Isao Morishima
Direct observation of the multistep helix formation of poly-L-glutamic acids.
Journal of the American Chemical Society 2002;124(39):11596-7.
2002: Furukawa Yoshiaki; Koichiro Ishimori; Isao Morishima
Oxidation-state-dependent protein docking between cytochrome c and cytochrome b(5): high-pressure laser flash photolysis study.
Biochemistry 2002;41(31):9824-32.
2002: Furukawa Yoshiaki; Fumihiro Matsuda; Koichiro Ishimori; Isao Morishima
Investigation of the electron-transfer mechanism by cross-linking between Zn-substituted myoglobin and cytochrome b(5).
Journal of the American Chemical Society 2002;124(15):4008-19.
2002: Shuji Akiyama; Satoshi Takahashi; Tetsunari Kimura; Koichiro Ishimori; Isao Morishima; Yukihiro Nishikawa; Tetsuro Fujisawa
Conformational landscape of cytochrome c folding studied by microsecond-resolved small-angle x-ray scattering.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1329-34.
2001: Kokichi Yamamoto; Haruto Ishikawa; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima; Hiroyuki Nakajima; Shigetoshi Aono
Binding of CO at the Pro2 side is crucial for the activation of CO-sensing transcriptional activator CooA. (1)H NMR spectroscopic studies.
The Journal of biological chemistry 2001;276(15):11473-6.
2001: Haruto Ishikawa; T Uchida; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Ligand migration in human myoglobin: steric effects of isoleucine 107(G8) on O(2) and CO binding.
Biophysical journal 2001;80(3):1507-17.
2001: Shiro Yoshioka; Satoshi Takahashi; Hiroshi Hori; Koichiro Ishimori; Isao Morishima
Proximal cysteine residue is essential for the enzymatic activities of cytochrome P450cam.
European journal of biochemistry / FEBS 2001;268(2):252-9.
2000: T Uchida; Koichiro Ishimori; Isao Morishima
Unusual pressure effects on ligand rebinding to the human myoglobin Leucine 29 mutants.
The Journal of biological chemistry 2000;275(39):30309-16.
2000: Furukawa Yoshiaki; Koichiro Ishimori; Isao Morishima
Electron transfer reactions in Zn-substituted cytochrome P450cam.
Biochemistry 2000;39(36):10996-1004.
2000: Shiro Yoshioka; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Roles of the axial push effect in cytochrome P450cam studied with the site-directed mutagenesis at the heme proximal site.
Journal of inorganic biochemistry 2000;81(3):141-51.
2000: Shuji Akiyama; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Stepwise formation of alpha-helices during cytochrome c folding.
Nature structural biology 2000;7(6):514-20.
2000: M Ihara; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima
Functions of fluctuation in the heme-binding loops of cytochrome b5 revealed in the process of heme incorporation.
Biochemistry 2000;39(20):5961-70.
2000: Kayo Inaba; Koichiro Ishimori; K Imai; Isao Morishima
Substitution of the heme binding module in hemoglobin alpha- and beta-subunits. Implication for different regulation mechanisms of the heme proximal structure between hemoglobin and myoglobin.
The Journal of biological chemistry 2000;275(17):12438-45.
1999: Masaru Tanaka; Koichiro Ishimori; Isao Morishima
Luminol activity of horseradish peroxidase mutants mimicking a proposed binding site for luminol in Arthromyces ramosus peroxidase.
Biochemistry 1999;38(32):10463-73.
1998: T Uchida; Haruto Ishikawa; Satoshi Takahashi; Koichiro Ishimori; Isao Morishima; K Ohkubo; Hiroyuki Nakajima; Shigetoshi Aono
Heme environmental structure of CooA is modulated by the target DNA binding. Evidence from resonance Raman spectroscopy and CO rebinding kinetics.
The Journal of biological chemistry 1998;273(32):19988-92.
1998: M Aoki; Koichiro Ishimori; Isao Morishima
NMR studies of putidaredoxin: associations of putidaredoxin with NADH-putidaredoxin reductase and cytochrome p450cam.
Biochimica et biophysica acta 1998;1386(1):168-78.
1998: M Aoki; Koichiro Ishimori; Isao Morishima
Roles of negatively charged surface residues of putidaredoxin in interactions with redox partners in p450cam monooxygenase system.
Biochimica et biophysica acta 1998;1386(1):157-67.
1998: Akira Morimoto; Masaru Tanaka; Satoshi Takahashi; Koichiro Ishimori; Hiroshi Hori; Isao Morishima
Detection of a tryptophan radical as an intermediate species in the reaction of horseradish peroxidase mutant (Phe-221 --> Trp) and hydrogen peroxide.
The Journal of biological chemistry 1998;273(24):14753-60.
1998: M Aoki; Koichiro Ishimori; H Fukada; K Takahashi; Isao Morishima
Isothermal titration calorimetric studies on the associations of putidaredoxin to NADH-putidaredoxin reductase and P450cam.
Biochimica et biophysica acta 1998;1384(1):180-8.
1998: Kayo Inaba; Koichiro Ishimori; K Imai; Isao Morishima
Structural and functional effects of pseudo-module substitution in hemoglobin subunits. New structural and functional units in globin structure.
The Journal of biological chemistry 1998;273(14):8080-7.
1998: Masaru Tanaka; Koichiro Ishimori; Isao Morishima
Structural roles of the highly conserved glu residue in the heme distal site of peroxidases.
Biochemistry 1998;37(8):2629-38.
1998: Kayo Inaba; Koichiro Ishimori; Isao Morishima
Structural and functional roles of heme binding module in globin proteins: identification of the segment regulating the heme binding structure.
Journal of molecular biology 1998;283(1):311-27.
1997: T Uchida; Koichiro Ishimori; Isao Morishima
The effects of heme pocket hydrophobicity on the ligand binding dynamics in myoglobin as studied with leucine 29 mutants.
The Journal of biological chemistry 1997;272(48):30108-14.
1997: Kayo Inaba; Keisuke Wakasugi; Koichiro Ishimori; T Konno; Mikio Kataoka; Isao Morishima
Structural and functional roles of modules in hemoglobin. Substitution of module M4 in hemoglobin subunits.
The Journal of biological chemistry 1997;272(48):30054-60.
1997: Keisuke Wakasugi; Koichiro Ishimori; Isao Morishima
'Module'-substituted globins: artificial exon shuffling among myoglobin, hemoglobin alpha- and beta-subunits.
Biophysical chemistry 1997;68(1-3):265-73.
1997: Masaru Tanaka; Koichiro Ishimori; M Mukai; Teizo Kitagawa; Isao Morishima
Catalytic activities and structural properties of horseradish peroxidase distal His42 --> Glu or Gln mutant.
Biochemistry 1997;36(32):9889-98.
1997: Masaru Tanaka; S Nagano; Koichiro Ishimori; Isao Morishima
Hydrogen bond network in the distal site of peroxidases: spectroscopic properties of Asn70 --> Asp horseradish peroxidase mutant.
Biochemistry 1997;36(32):9791-8.
1997: T Uchida; M Unno; Koichiro Ishimori; Isao Morishima
Effects of the intramolecular disulfide bond on ligand binding dynamics in myoglobin.
Biochemistry 1997;36(2):324-32.
1996: S Nagano; M Tanaka; Koichiro Ishimori; Y Watanabe; Isao Morishima
Catalytic roles of the distal site asparagine-histidine couple in peroxidases.
Biochemistry 1996;35(45):14251-8.
1996: M Tanaka; Koichiro Ishimori; Isao Morishima
The distal glutamic acid as an acid-base catalyst in the distal site of horseradish peroxidase.
Biochemical and biophysical research communications 1996;227(2):393-9.
1996: T Matsui; S Nagano; Koichiro Ishimori; Y Watanabe; Isao Morishima
Preparation and reactions of myoglobin mutants bearing both proximal cysteine ligand and hydrophobic distal cavity: protein models for the active site of P-450.
Biochemistry 1996;35(40):13118-24.
1996: Keisuke Wakasugi; Koichiro Ishimori; Isao Morishima
NMR studies of recombinant cytochrome P450cam mutants.
Biochimie 1996;78(8-9):763-70.
1994: M Unno; Koichiro Ishimori; Y Ishimura; Isao Morishima
High-pressure flash photolysis study of hemoprotein: effects of substrate analogues on the recombination of carbon monoxide to cytochrome P450CAM.
Biochemistry 1994;33(32):9762-8.
1994: Keisuke Wakasugi; Koichiro Ishimori; K Imai; Y Wada; Isao Morishima
"Module" substitution in hemoglobin subunits. Preparation and characterization of a "chimera beta alpha-subunit".
The Journal of biological chemistry 1994;269(29):18750-6.
1994: Koichiro Ishimori; M Hashimoto; K Imai; K Fushitani; Gentaro Miyazaki; Hideki Morimoto; Y Wada; Isao Morishima
Site-directed mutagenesis in hemoglobin: functional and structural role of the penultimate tyrosine in the alpha subunit.
Biochemistry 1994;33(9):2546-53.
1993: M Hashimoto; Koichiro Ishimori; K Imai; Gentaro Miyazaki; Hideki Morimoto; Y Wada; Isao Morishima
Site-directed mutagenesis in hemoglobin: functional and structural study of the intersubunit hydrogen bond of threonine-38(C3)alpha at the alpha 1-beta 2 interface in human hemoglobin.
Biochemistry 1993;32(49):13688-95.
1993: A Togi; Koichiro Ishimori; M Unno; T Konno; Isao Morishima; Gentaro Miyazaki; K Imai
Effects of intra- and intersubunit hydrogen bonds on the R-T transition in human hemoglobin as studied with alpha 42(C7) and beta 145(HC2) mutations.
Biochemistry 1993;32(38):10165-9.
1993: S Adachi; S Nagano; Koichiro Ishimori; Y Watanabe; Isao Morishima; Tsuyoshi Egawa; Teizo Kitagawa; R Makino
Roles of proximal ligand in heme proteins: replacement of proximal histidine of human myoglobin with cysteine and tyrosine by site-directed mutagenesis as models for P-450, chloroperoxidase, and catalase.
Biochemistry 1993;32(1):241-52.
1992: S Adachi; N Sunohara; Koichiro Ishimori; Isao Morishima
Structure and ligand binding properties of leucine 29(B10) mutants of human myoglobin.
The Journal of biological chemistry 1992;267(18):12614-21.
1992: Koichiro Ishimori; K Imai; Gentaro Miyazaki; Teizo Kitagawa; Y Wada; Hideki Morimoto; Isao Morishima
Site-directed mutagenesis in hemoglobin: functional and structural role of inter- and intrasubunit hydrogen bonds as studied with 37 beta and 145 beta mutations.
Biochemistry 1992;31(12):3256-64.
1991: M Unno; Koichiro Ishimori; Isao Morishima; T Nakayama; K Hamanoue
Pressure effects on carbon monoxide rebinding to the isolated alpha and beta chains of human hemoglobin.
Biochemistry 1991;30(44):10679-85.
1991: S Adachi; S Nagano; Y Watanabe; Koichiro Ishimori; Isao Morishima
Alteration of human myoglobin proximal histidine to cysteine or tyrosine by site-directed mutagenesis: characterization and their catalytic activities.
Biochemical and biophysical research communications 1991;180(1):138-44.
1991: K Imai; K Fushitani; Gentaro Miyazaki; Koichiro Ishimori; T Kitagawa; Y Wada; Hideki Morimoto; Isao Morishima; D T Shih; Jeremy R H Tame
Site-directed mutagenesis in haemoglobin. Functional role of tyrosine-42(C7) alpha at the alpha 1-beta 2 interface.
Journal of molecular biology 1991;218(4):769-78.
1990: M Unno; Koichiro Ishimori; Isao Morishima
High-pressure laser photolysis study of hemoproteins. Effects of pressure on carbon monoxide binding dynamics for R- and T-state hemoglobins.
Biochemistry 1990;29(44):10199-205.
1989: Koichiro Ishimori; A Tsuneshige; K Imai; Isao Morishima
Ruthenium-iron hybrid hemoglobins as a model for partially liganded hemoglobin: oxygen equilibrium curves and resonance Raman spectra.
Biochemistry 1989;28(21):8603-9.
1989: Koichiro Ishimori; Isao Morishima; K Imai; K Fushitani; Gentaro Miyazaki; D Shih; Jeremy R H Tame; J Pegnier; K Nigai
NMR study of human mutant hemoglobins synthesized in Escherichia coli. Consequences of tyrosine alpha 42 substitutions.
The Journal of biological chemistry 1989;264(25):14624-6.
1988: Koichiro Ishimori; Isao Morishima
Study of the specific heme orientation in reconstituted hemoglobins.
Biochemistry 1988;27(13):4747-53.
1988: Koichiro Ishimori; Isao Morishima
Ruthenium-iron hybrid hemoglobins as a model for partially liganded hemoglobin: NMR studies of their tertiary and quaternary structures.
Biochemistry 1988;27(11):4060-6.