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Toshimasa Ishizaki

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Chemicals & Drugs

Living Beings

Mice

Anatomy

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequence

Physiology

Signal Transduction

Phenomena

Phosphorylation

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Co-Publications
Name
33
Narumiya, Shuh
16
Watanabe, Naoki
9
Saito, Yoshihiko
8
Madaule, P
6
Bito, Haruhiko
6
Kato, Takayuki
6
Watanabe, Go
5
Fujita, A
4
Furuyashiki, Tomoyuki
3
Eda, M
3
Keel, Jeongsin
3
Okamoto, Muneo
3
Uehata, Masayoshi
2
Arakawa, Yoshiki
2
Yasuda, Shingo

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Publications

TOP 3
Narumiya Shuh; Tanji Masahiro; Ishizaki Toshimasa
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Miki Takashi; Okawa Katsuya; Sekimoto Toshihiro; Yoneda Yoshihiro; Watanabe Sadanori; Ishizaki Toshimasa; Narumiya Shuh
mDia2 shuttles between the nucleus and the cytoplasm through the importin-{alpha}/{beta}- and CRM1-mediated nuclear transport mechanism.
Watanabe Sadanori; Ando Yoshikazu; Yasuda Shingo; Hosoya Hiroshi; Watanabe Naoki; Ishizaki Toshimasa; Narumiya Shuh
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells.

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All Publications

2009: Narumiya Shuh; Tanji Masahiro; Ishizaki Toshimasa
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Cancer metastasis reviews 2009;28(1-2):65-76.
2009: Miki Takashi; Okawa Katsuya; Sekimoto Toshihiro; Yoneda Yoshihiro; Watanabe Sadanori; Ishizaki Toshimasa; Narumiya Shuh
mDia2 shuttles between the nucleus and the cytoplasm through the importin-{alpha}/{beta}- and CRM1-mediated nuclear transport mechanism.
The Journal of biological chemistry 2009;284(9):5753-62.
2008: Watanabe Sadanori; Ando Yoshikazu; Yasuda Shingo; Hosoya Hiroshi; Watanabe Naoki; Ishizaki Toshimasa; Narumiya Shuh
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells.
Molecular biology of the cell 2008;19(5):2328-38.
2006: Yamana Norikazu; Arakawa Yoshiki; Nishino Tomohiro; Kurokawa Kazuo; Tanji Masahiro; Itoh Reina E; Monypenny James; Ishizaki Toshimasa; Bito Haruhiko; Nozaki Kazuhiko; Hashimoto Nobuo; Matsuda Michiyuki; Narumiya Shuh
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.
Molecular and cellular biology 2006;26(18):6844-58.
2005: Shimizu Yoshihiko; Thumkeo Dean; Keel Jeongsin; Ishizaki Toshimasa; Oshima Hiroko; Oshima Masanobu; Noda Yoichi; Matsumura Fumio; Taketo Makoto M; Narumiya Shuh
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles.
The Journal of cell biology 2005;168(6):941-53.
2004: Yasuda Shingo; Oceguera-Yanez Fabian; Kato Takayuki; Okamoto Muneo; Yonemura Shigenobu; Terada Yasuhiko; Ishizaki Toshimasa; Narumiya Shuh
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Nature 2004;428(6984):767-71.
2003: Thumkeo Dean; Keel Jeongsin; Ishizaki Toshimasa; Hirose Masaya; Nonomura Kimiko; Oshima Hiroko; Oshima Masanobu; Taketo Makoto M; Narumiya Shuh
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.
Molecular and cellular biology 2003;23(14):5043-55.
2003: Ishizaki Toshimasa
[Rho-mediated signal transduction and its physiological roles]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2003;121(3):153-62.
2002: Tsuji Takahiro; Ishizaki Toshimasa; Okamoto Muneo; Higashida Chiharu; Kimura Kazuhiro; Furuyashiki Tomoyuki; Arakawa Yoshiki; Birge Raymond B; Nakamoto Tetsuya; Hirai Hisamaru; Narumiya Shuh
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts.
The Journal of cell biology 2002;157(5):819-30.
2001: Eda M; Yonemura S; Kato T; Watanabe N; Ishizaki T; Madaule P; Narumiya S
Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells.
Journal of cell science 2001;114(Pt 18):3273-84.
2001: Kato T; Watanabe N; Morishima Y; Fujita A; Ishizaki T; Narumiya S
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells.
Journal of cell science 2001;114(Pt 4):775-84.
2001: Ishizaki T; Morishima Y; Okamoto M; Furuyashiki T; Kato T; Narumiya S
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.
Nature cell biology 2001;3(1):8-14.
2000: Bito H; Furuyashiki T; Ishihara H; Shibasaki Y; Ohashi K; Mizuno K; Maekawa M; Ishizaki T; Narumiya S
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
Neuron 2000;26(2):431-41.
2000: Ishizaki T; Uehata M; Tamechika I; Keel J; Nonomura K; Maekawa M; Narumiya S
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
Molecular pharmacology 2000;57(5):976-83.
2000: Madaule P; Furuyashiki T; Eda M; Bito H; Ishizaki T; Narumiya S
Citron, a Rho target that affects contractility during cytokinesis.
Microscopy research and technique 2000;49(2):123-6.
2000: Fujita A; Nakamura K; Kato T; Watanabe N; Ishizaki T; Kimura K; Mizoguchi A; Narumiya S
Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.
Journal of cell science 2000;113 ( Pt 1)():103-12.
2000: Narumiya S; Ishizaki T; Uehata M
Use and properties of ROCK-specific inhibitor Y-27632.
Methods in enzymology 2000;325():273-84.
1999: Maekawa M; Ishizaki T; Boku S; Watanabe N; Fujita A; Iwamatsu A; Obinata T; Ohashi K; Mizuno K; Narumiya S
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Science (New York, N.Y.) 1999;285(5429):895-8.
1999: Watanabe N; Kato T; Fujita A; Ishizaki T; Narumiya S
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.
Nature cell biology 1999;1(3):136-43.
1999: Nakamura K; Fujita A; Murata T; Watanabe G; Mori C; Fujita J; Watanabe N; Ishizaki T; Yoshida O; Narumiya S
Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail.
FEBS letters 1999;445(1):9-13.
1998: Madaule P; Eda M; Watanabe N; Fujisawa K; Matsuoka T; Bito H; Ishizaki T; Narumiya S
Role of citron kinase as a target of the small GTPase Rho in cytokinesis.
Nature 1998;394(6692):491-4.
1998: Fujisawa K; Madaule P; Ishizaki T; Watanabe G; Bito H; Saito Y; Hall A; Narumiya S
Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.
The Journal of biological chemistry 1998;273(30):18943-9.
1998: Hirose M; Ishizaki T; Watanabe N; Uehata M; Kranenburg O; Moolenaar W H; Matsumura F; Maekawa M; Bito H; Narumiya S
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.
The Journal of cell biology 1998;141(7):1625-36.
1997: Narumiya S; Ishizaki T; Watanabe N
Rho effectors and reorganization of actin cytoskeleton.
FEBS letters 1997;410(1):68-72.
1997: Watanabe N; Madaule P; Reid T; Ishizaki T; Watanabe G; Kakizuka A; Saito Y; Nakao K; Jockusch B M; Narumiya S
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
The EMBO journal 1997;16(11):3044-56.
1997: Ishizaki T; Naito M; Fujisawa K; Maekawa M; Watanabe N; Saito Y; Narumiya S
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions.
FEBS letters 1997;404(2-3):118-24.
1996: Fujisawa K; Fujita A; Ishizaki T; Saito Y; Narumiya S
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
The Journal of biological chemistry 1996;271(38):23022-8.
1996: Nakagawa O; Fujisawa K; Ishizaki T; Saito Y; Nakao K; Narumiya S
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.
FEBS letters 1996;392(2):189-93.
1996: Reid T; Furuyashiki T; Ishizaki T; Watanabe G; Watanabe N; Fujisawa K; Morii N; Madaule P; Narumiya S
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.
The Journal of biological chemistry 1996;271(23):13556-60.
1996: Ishizaki T; Maekawa M; Fujisawa K; Okawa K; Iwamatsu A; Fujita A; Watanabe N; Saito Y; Kakizuka A; Morii N; Narumiya S
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
The EMBO journal 1996;15(8):1885-93.
1996: Watanabe G; Saito Y; Madaule P; Ishizaki T; Fujisawa K; Morii N; Mukai H; Ono Y; Kakizuka A; Narumiya S
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho.
Science (New York, N.Y.) 1996;271(5249):645-8.
1995: Madaule P; Furuyashiki T; Reid T; Ishizaki T; Watanabe G; Morii N; Narumiya S
A novel partner for the GTP-bound forms of rho and rac.
FEBS letters 1995;377(2):243-8.
1995: Saito Y; Nemoto Y; Ishizaki T; Watanabe N; Morii N; Narumiya S
Identification of Glu173 as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzyme.
FEBS letters 1995;371(2):105-9.
1995: Kumagai N; Morii N; Ishizaki T; Watanabe N; Fujisawa K; Saito Y; Narumiya S
Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling.
FEBS letters 1995;366(1):11-6.

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