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Toshimasa Ishizaki

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Chemicals & Drugs

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Mouse

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Signal Transduction

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Amino Acid Sequences

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Sadanori Watanabe; Tihana De Zan; Toshimasa Ishizaki; Shuh Narumiya
Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
Ryota Shinohara; Hirohide Takebayashi; Dean Thumkeo; Keisuke Watanabe; Tomoyuki Furuyashiki; Toshimasa Ishizaki; Hiroshi Kamijo; Naoko Kaneko; Hiroshi Kiyonari; Kazunobu Sawamoto; Shuh Narumiya
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Satoko Sakamoto; Naoki Watanabe; Sadanori Watanabe; Takatoshi Arakawa; Toshimasa Ishizaki; Katsuya Okawa; Shuh Narumiya
Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization.

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2013: Sadanori Watanabe; Tihana De Zan; Toshimasa Ishizaki; Shuh Narumiya
Citron kinase mediates transition from constriction to abscission through its coiled-coil domain.
Journal of cell science 2013;126(Pt 8):1773-84.
2012: Ryota Shinohara; Hirohide Takebayashi; Dean Thumkeo; Keisuke Watanabe; Tomoyuki Furuyashiki; Toshimasa Ishizaki; Hiroshi Kamijo; Naoko Kaneko; Hiroshi Kiyonari; Kazunobu Sawamoto; Shuh Narumiya
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Nature neuroscience 2012;15(3):373-80, S1-2.
2012: Satoko Sakamoto; Naoki Watanabe; Sadanori Watanabe; Takatoshi Arakawa; Toshimasa Ishizaki; Katsuya Okawa; Shuh Narumiya
Liprin-α controls stress fiber formation by binding to mDia and regulating its membrane localization.
Journal of cell science 2012;125(Pt 1):108-20.
2011: Hiroshi Kamijo; Seiichi Koike; Masayuki Masu; Yutaka Matsumura; Yoshihiko Shimizu; Dean Thumkeo; Toshimasa Ishizaki; Shuh Narumiya
Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(10):1012-21.
2011: Dean Thumkeo; Kiyoshi Tohyama; Yosuke Toyoda; Keisuke Watanabe; Tomoyuki Furuyashiki; Toshimasa Ishizaki; Ryota Shinohara; Hirohide Takebayashi; Shuh Narumiya
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
PloS one 2011;6(9):e25465.
2010: Masahiro Tanji; Toshimasa Ishizaki; Saman Ebrahimi; Yuko Tsuboguchi; Taiko Sukezane; Tsuyoshi Akagi; Margaret C Frame; Nobuo Hashimoto; Susumu Miyamoto; Shuh Narumiya
mDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasion.
Molecular and cellular biology 2010;30(19):4604-15.
2009: Shuh Narumiya; Masahiro Tanji; Toshimasa Ishizaki
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion.
Cancer metastasis reviews 2009;28(1-2):65-76.
2009: Takashi Miki; Katsuya Okawa; Toshihiro Sekimoto; Yoshihiro Yoneda; Sadanori Watanabe; Toshimasa Ishizaki; Shuh Narumiya
mDia2 shuttles between the nucleus and the cytoplasm through the importin-{alpha}/{beta}- and CRM1-mediated nuclear transport mechanism.
The Journal of biological chemistry 2009;284(9):5753-62.
2008: Sadanori Watanabe; Yoshikazu Ando; Shingo Yasuda; Hiroshi Hosoya; Naoki Watanabe; Toshimasa Ishizaki; Shuh Narumiya
mDia2 induces the actin scaffold for the contractile ring and stabilizes its position during cytokinesis in NIH 3T3 cells.
Molecular biology of the cell 2008;19(5):2328-38.
2006: Norikazu Yamana; Yoshiki Arakawa; Tomohiro Nishino; Kazuo Kurokawa; Masahiro Tanji; Reina E Itoh; James Monypenny; Toshimasa Ishizaki; Haruhiko Bito; Kazuhiko Nozaki; Nobuo Hashimoto; Michiyuki Matsuda; Shuh Narumiya
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src.
Molecular and cellular biology 2006;26(18):6844-58.
2005: Yoshihiko Shimizu; Dean Thumkeo; Jeongsin Keel; Toshimasa Ishizaki; Hiroko Oshima; Masanobu Oshima; Yoichi Noda; Fumio Matsumura; Makoto M Taketo; Shuh Narumiya
ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles.
The Journal of cell biology 2005;168(6):941-53.
2004: Shingo Yasuda; Fabian Oceguera-Yanez; Takayuki Kato; Muneo Okamoto; Shigenobu Yonemura; Yasuhiko Terada; Toshimasa Ishizaki; Shuh Narumiya
Cdc42 and mDia3 regulate microtubule attachment to kinetochores.
Nature 2004;428(6984):767-71.
2003: Dean Thumkeo; Jeongsin Keel; Toshimasa Ishizaki; Masaya Hirose; Kimiko Nonomura; Hiroko Oshima; Masanobu Oshima; Makoto M Taketo; Shuh Narumiya
Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death.
Molecular and cellular biology 2003;23(14):5043-55.
2003: Toshimasa Ishizaki
[Rho-mediated signal transduction and its physiological roles].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;121(3):153-62.
2002: Takahiro Tsuji; Toshimasa Ishizaki; Muneo Okamoto; Chiharu Higashida; Kazuhiro Kimura; Tomoyuki Furuyashiki; Yoshiki Arakawa; Raymond B Birge; Tetsuya Nakamoto; Hisamaru Hirai; Shuh Narumiya
ROCK and mDia1 antagonize in Rho-dependent Rac activation in Swiss 3T3 fibroblasts.
The Journal of cell biology 2002;157(5):819-30.
2001: M Eda; Shigenobu Yonemura; Takayuki Kato; Naoki Watanabe; Toshimasa Ishizaki; P Madaule; Shuh Narumiya
Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells.
Journal of cell science 2001;114(Pt 18):3273-84.
2001: Takayuki Kato; Naoki Watanabe; Y Morishima; A Fujita; Toshimasa Ishizaki; Shuh Narumiya
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells.
Journal of cell science 2001;114(Pt 4):775-84.
2001: Toshimasa Ishizaki; Yosuke Morishima; Muneo Okamoto; Tomoyuki Furuyashiki; Takayuki Kato; Shuh Narumiya
Coordination of microtubules and the actin cytoskeleton by the Rho effector mDia1.
Nature cell biology 2001;3(1):8-14.
2000: Haruhiko Bito; Tomoyuki Furuyashiki; H Ishihara; Y Shibasaki; K Ohashi; Kensaku Mizuno; M Maekawa; Toshimasa Ishizaki; Shuh Narumiya
A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
Neuron 2000;26(2):431-41.
2000: Toshimasa Ishizaki; Masayoshi Uehata; I Tamechika; Jeongsin Keel; K Nonomura; M Maekawa; Shuh Narumiya
Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.
Molecular pharmacology 2000;57(5):976-83.
2000: P Madaule; Tomoyuki Furuyashiki; M Eda; Haruhiko Bito; Toshimasa Ishizaki; Shuh Narumiya
Citron, a Rho target that affects contractility during cytokinesis.
Microscopy research and technique 2000;49(2):123-6.
2000: Shuh Narumiya; Toshimasa Ishizaki; Masayoshi Uehata
Use and properties of ROCK-specific inhibitor Y-27632.
Methods in enzymology 2000;325():273-84.
2000: A Fujita; Kozo Nakamura; Takayuki Kato; Naoki Watanabe; Toshimasa Ishizaki; Kazuhiro Kimura; A Mizoguchi; Shuh Narumiya
Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibrous sheath of sperm flagella.
Journal of cell science 2000;113 ( Pt 1)():103-12.
1999: M Maekawa; Toshimasa Ishizaki; S Boku; Naoki Watanabe; Akiko Fujita; A Iwamatsu; T Obinata; K Ohashi; Kensaku Mizuno; Shuh Narumiya
Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
Science (New York, N.Y.) 1999;285(5429):895-8.
1999: Naoki Watanabe; Takayuki Kato; A Fujita; Toshimasa Ishizaki; Shuh Narumiya
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization.
Nature cell biology 1999;1(3):136-43.
1999: Kozo Nakamura; A Fujita; T Murata; Go Watanabe; Chisato Mori; Jun Fujita; Naoki Watanabe; Toshimasa Ishizaki; O Yoshida; Shuh Narumiya
Rhophilin, a small GTPase Rho-binding protein, is abundantly expressed in the mouse testis and localized in the principal piece of the sperm tail.
FEBS letters 1999;445(1):9-13.
1998: P Madaule; M Eda; Naoki Watanabe; K Fujisawa; Toshiyuki Matsuoka; Haruhiko Bito; Toshimasa Ishizaki; Shuh Narumiya
Role of citron kinase as a target of the small GTPase Rho in cytokinesis.
Nature 1998;394(6692):491-4.
1998: K Fujisawa; P Madaule; Toshimasa Ishizaki; Go Watanabe; Haruhiko Bito; Yoshihiko Saito; Alan Hall; Shuh Narumiya
Different regions of Rho determine Rho-selective binding of different classes of Rho target molecules.
The Journal of biological chemistry 1998;273(30):18943-9.
1998: M Hirose; Toshimasa Ishizaki; Naoki Watanabe; Masayoshi Uehata; Onno Kranenburg; Wouter H Moolenaar; F Matsumura; M Maekawa; Haruhiko Bito; Shuh Narumiya
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.
The Journal of cell biology 1998;141(7):1625-36.
1997: Shuh Narumiya; Toshimasa Ishizaki; Naoki Watanabe
Rho effectors and reorganization of actin cytoskeleton.
FEBS letters 1997;410(1):68-72.
1997: Naoki Watanabe; P Madaule; T Reid; Toshimasa Ishizaki; Go Watanabe; Akira Kakizuka; Yoshihiko Saito; Kazuwa Nakao; B M Jockusch; Shuh Narumiya
p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin.
The EMBO journal 1997;16(11):3044-56.
1997: Toshimasa Ishizaki; M Naito; K Fujisawa; M Maekawa; Naoki Watanabe; Yoshihiko Saito; Shuh Narumiya
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesions.
FEBS letters 1997;404(2-3):118-24.
1996: K Fujisawa; A Fujita; Toshimasa Ishizaki; Yoshihiko Saito; Shuh Narumiya
Identification of the Rho-binding domain of p160ROCK, a Rho-associated coiled-coil containing protein kinase.
The Journal of biological chemistry 1996;271(38):23022-8.
1996: O Nakagawa; K Fujisawa; Toshimasa Ishizaki; Yoshihiko Saito; Kazuwa Nakao; Shuh Narumiya
ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice.
FEBS letters 1996;392(2):189-93.
1996: T Reid; T Furuyashiki; Toshimasa Ishizaki; Go Watanabe; Naoki Watanabe; K Fujisawa; N Morii; P Madaule; Shuh Narumiya
Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain.
The Journal of biological chemistry 1996;271(23):13556-60.
1996: Toshimasa Ishizaki; M Maekawa; K Fujisawa; K Okawa; A Iwamatsu; A Fujita; Naoki Watanabe; Yoshihiko Saito; A Kakizuka; N Morii; Shuh Narumiya
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase.
The EMBO journal 1996;15(8):1885-93.
1996: Go Watanabe; Yoshihiko Saito; P Madaule; Toshimasa Ishizaki; K Fujisawa; N Morii; H Mukai; Y Ono; A Kakizuka; Shuh Narumiya
Protein kinase N (PKN) and PKN-related protein rhophilin as targets of small GTPase Rho.
Science (New York, N.Y.) 1996;271(5249):645-8.
1995: P Madaule; T Furuyashiki; T Reid; Toshimasa Ishizaki; Go Watanabe; N Morii; Shuh Narumiya
A novel partner for the GTP-bound forms of rho and rac.
FEBS letters 1995;377(2):243-8.
1995: Yoshihiko Saito; Y Nemoto; Toshimasa Ishizaki; Naoki Watanabe; N Morii; Shuh Narumiya
Identification of Glu173 as the critical amino acid residue for the ADP-ribosyltransferase activity of Clostridium botulinum C3 exoenzyme.
FEBS letters 1995;371(2):105-9.
1995: N Kumagai; N Morii; Toshimasa Ishizaki; Naoki Watanabe; K Fujisawa; Yoshihiko Saito; Shuh Narumiya
Lysophosphatidic acid-induced activation of protein Ser/Thr kinases in cultured rat 3Y1 fibroblasts. Possible involvement in rho p21-mediated signalling.
FEBS letters 1995;366(1):11-6.