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Jeffrey Isner

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Rudolf Kirchmair; Anne B Tietz; Eleftheria Panagiotou; Dirk H Walter; Marcy Silver; Young-sup Yoon; Peter Schratzberger; Alberto Weber; Kengo Kusano; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
Bernhard Witzenbichler; Abderrahim Mahfoudi; Fabienne Soubrier; Aude Le-Roux; Didier Branellec; Heinz-Peter Schultheiss; Jeffrey M Isner
Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model.
Rudolf Kirchmair; Dirk H Walter; Masaaki Ii; Kilian Rittig; Anne B Tietz; Toshinori Murayama; Costanza Emanueli; Marcy Silver; Andrea Wecker; Carole Amant; Peter Schratzberger; Young-sup Yoon; Alberto Weber; Eleftheria Panagiotou; Kenneth M Rosen; Ferdinand H Bahlmann; Lester S Adelman; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.

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2007: Rudolf Kirchmair; Anne B Tietz; Eleftheria Panagiotou; Dirk H Walter; Marcy Silver; Young-sup Yoon; Peter Schratzberger; Alberto Weber; Kengo Kusano; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):69-75.
2006: Bernhard Witzenbichler; Abderrahim Mahfoudi; Fabienne Soubrier; Aude Le-Roux; Didier Branellec; Heinz-Peter Schultheiss; Jeffrey M Isner
Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model.
Journal of molecular medicine (Berlin, Germany) 2006;84(6):491-502.
2005: Rudolf Kirchmair; Dirk H Walter; Masaaki Ii; Kilian Rittig; Anne B Tietz; Toshinori Murayama; Costanza Emanueli; Marcy Silver; Andrea Wecker; Carole Amant; Peter Schratzberger; Young-sup Yoon; Alberto Weber; Eleftheria Panagiotou; Kenneth M Rosen; Ferdinand H Bahlmann; Lester S Adelman; David H Weinberg; Allan H Ropper; Jeffrey M Isner; Douglas Losordo
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.
Circulation 2005;111(20):2662-70.
2005: Shin-ichiro Hayashi; Takayuki Asahara; Haruchika Masuda; Jeffrey M Isner; Douglas Losordo
Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization.
Circulation 2005;111(17):2210-8.
2005: Young-sup Yoon; Shigeki Uchida; Osamu Masuo; Manfred Cejna; Jong-Seon Park; Hyeon-Cheol Gwon; Rudolf Kirchmair; Ferdinand Bahlman; Dirk Walter; Cynthia Curry; Allison Hanley; Jeffrey M Isner; Douglas Losordo
Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor.
Circulation 2005;111(16):2073-85.
2005: MARTA BOSCH; Roberto Pola; Andrea Wecker; Marcy Silver; Alberto Weber; Corinne Luedemann; Cynthia Curry; Toshinori Murayama; Marianne Kearney; Young-sup Yoon; M Rene Malinow; Takayuki Asahara; Jeffrey M Isner; Douglas Losordo
Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia.
Vascular medicine (London, England) 2005;10(1):15-22.
2005: John P Reilly; Mark A Grise; F David Fortuin; Peter Vale; Gary L Schaer; John Lopez; Joseph R VAN Camp; Timothy Henry; Wayne Richenbacher; Douglas Losordo; Richard A Schatz; Jeffrey M Isner
Long-term (2-year) clinical events following transthoracic intramyocardial gene transfer of VEGF-2 in no-option patients.
Journal of interventional cardiology 2005;18(1):27-31.
2004: Roberto Pola; Tamar R Aprahamian; MARTA BOSCH; Cynthia Curry; Eleonora Gaetani; Andrea Flex; Roy Smith; Jeffrey M Isner; Douglas Losordo
Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves.
Neurobiology of aging 2004;25(10):1361-8.
2004: Dirk H Walter; Manfred Cejna; Larry J Diaz-Sandoval; Sean Willis; Laura Kirkwood; Peter W Stratford; Anne B Tietz; Rudolf Kirchmair; Marcy Silver; Cynthia Curry; Andrea Wecker; Young-sup Yoon; Regina Heidenreich; Allison Hanley; Marianne Kearney; Fermin O Tio; Patrik Kuenzler; Jeffrey M Isner; Douglas Losordo
Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis.
Circulation 2004;110(1):36-45.
2003: Atsushi Iwakura; Corinne Luedemann; Shubha Shastry; Allison Hanley; Marianne Kearney; Ryuichi Aikawa; Jeffrey M Isner; Takayuki Asahara; Douglas Losordo
Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury.
Circulation 2003;108(25):3115-21.
2003: F David Fortuin; Peter Vale; Douglas Losordo; James Symes; Giacomo A DeLaria; J Jeffrey Tyner; Gary L Schaer; Robert March; R Jeffrey Snell; Timothy D Henry; Joseph Van Camp; John J Lopez; Wayne Richenbacher; Jeffrey M Isner; Richard A Schatz
One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients.
The American journal of cardiology 2003;92(4):436-9.
2003: Roberto Pola; Leona E Ling; Tamar R Aprahamian; Elena Barban; MARTA BOSCH; Cynthia Curry; Michael Corbley; Marianne Kearney; Jeffrey M Isner; Douglas Losordo
Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.
Circulation 2003;108(4):479-85.
2003: David Goukassian; Raj Kishore; Kevin Krasinski; Christine Dolan; Corinne Luedemann; Young-sup Yoon; Marianne Kearney; Allison Hanley; Hong Ma; Takayuki Asahara; Jeffrey M Isner; Douglas Losordo
Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth.
Circulation research 2003;93(2):162-9.
2003: Kou-Gi Shyu; Hang Chang; Jeffrey M Isner
Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia.
Life sciences 2003;73(5):563-79.
2003: Douglas Losordo; Jeffrey M Isner; Larry J Diaz-Sandoval
Endothelial recovery: the next target in restenosis prevention.
Circulation 2003;107(21):2635-7.
2003: Jun-ichi Yamaguchi; Kengo Fukushima Kusano; Osamu Masuo; Atsuhiko Kawamoto; Marcy Silver; Satoshi Murasawa; MARTA BOSCH; Haruchika Masuda; Douglas Losordo; Jeffrey M Isner; Takayuki Asahara
Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization.
Circulation 2003;107(9):1322-8.
2003: Young-sup Yoon; Toshinori Murayama; Edwin Gravereaux; Tengiz Tkebuchava; Marcy Silver; Cynthia Curry; Andrea Wecker; Rudolf Kirchmair; Chun Song Hu; Marianne Kearney; Alan Ashare; David G Jackson; Hajime Kubo; Jeffrey M Isner; Douglas Losordo
VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.
The Journal of clinical investigation 2003;111(5):717-25.
2003: Atsuhiko Kawamoto; Tengiz Tkebuchava; Jun-ichi Yamaguchi; Hiromi Nishimura; Young-sup Yoon; Charles E Milliken; Shigeki Uchida; Osamu Masuo; Hideki Iwaguro; Hong Ma; Allison Hanley; Marcy Silver; Marianne Kearney; Douglas Losordo; Jeffrey M Isner; Takayuki Asahara
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia.
Circulation 2003;107(3):461-8.
2002: Peter Schratzberger; Joseph G Krainin; Gabriele Schratzberger; Marcy Silver; Hong Ma; Marianne Kearney; Robert F Zuk; Axel F Brisken; Douglas Losordo; Jeffrey M Isner
Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):576-83.
2002: Saul B Freedman; Peter Vale; Christoph Kalka; Marianne Kearney; Anne Pieczek; James Symes; Douglas Losordo; Jeffrey M Isner
Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA.
Human gene therapy 2002;13(13):1595-603.
2002: Satoshi Murasawa; Joan Llevadot; Marcy Silver; Jeffrey M Isner; Douglas Losordo; Takayuki Asahara
Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells.
Circulation 2002;106(9):1133-9.
2002: Dirk H Walter; Kilian Rittig; Ferdinand H Bahlmann; Rudolf Kirchmair; Marcy Silver; Toshinori Murayama; Hiromi Nishimura; Douglas Losordo; Takayuki Asahara; Jeffrey M Isner
Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.
Circulation 2002;105(25):3017-24.
2002: Ioakim Spyridopoulos; Corinne Luedemann; Donghui Chen; Marianne Kearney; Dongfen Chen; Toyoaki Murohara; Nicole Principe; Jeffrey M Isner; Douglas Losordo
Divergence of angiogenic and vascular permeability signaling by VEGF: inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(6):901-6.
2002: Douglas Losordo; Peter Vale; Robert Charles Hendel; Charles E Milliken; F David Fortuin; Nancie Cummings; Richard A Schatz; Takayuki Asahara; Jeffrey M Isner; Richard E Kuntz
Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.
Circulation 2002;105(17):2012-8.
2002: Takayuki Asahara; Jeffrey M Isner
Endothelial progenitor cells for vascular regeneration.
Journal of hematotherapy & stem cell research 2002;11(2):171-8.
2002: Ioakim Spyridopoulos; Jeffrey M Isner; Douglas Losordo
Oncogenic ras induces premature senescence in endothelial cells: role of p21(Cip1/Waf1).
Basic research in cardiology 2002;97(2):117-24.
2002: Hideki Iwaguro; Jun-ichi Yamaguchi; Christoph Kalka; Satoshi Murasawa; Haruchika Masuda; Shin-ichiro Hayashi; Marcy Silver; Tong Li; Jeffrey M Isner; Takayuki Asahara
Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration.
Circulation 2002;105(6):732-8.
2002: Costanza Emanueli; Maria Bonaria Salis; Tiziana Stacca; Gianfranco Pintus; Rudolf Kirchmair; Jeffrey M Isner; Alessandra Pinna; Leonardo Gaspa; Domenico Regoli; Cécile Cayla; João B Pesquero; Michael Bader; Paolo Madeddu
Targeting kinin B(1) receptor for therapeutic neovascularization.
Circulation 2002;105(3):360-6.
2002: Jeffrey M Isner
Myocardial gene therapy.
Nature 2002;415(6868):234-9.
2002: Riyaz Bashir; Peter Vale; Jeffrey M Isner; Douglas Losordo
Angiogenic gene therapy: pre-clinical studies and phase I clinical data.
Kidney international 2002;61(1 Suppl):S110-4.
2002: Saul B Freedman; Jeffrey M Isner
Therapeutic angiogenesis for coronary artery disease.
Annals of internal medicine 2002;136(1):54-71.
2001: Timothy D Henry; Krishna Rocha-Singh; Jeffrey M Isner; D J Kereiakes; Frank J Giordano; M Simons; Douglas Losordo; Robert Charles Hendel; R O Bonow; S M Eppler; Thomas F Zioncheck; E B Holmgren; Ted McCluskey
Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease.
American heart journal 2001;142(5):872-80.
2001: Peter Vale; Jeffrey M Isner; K Rosenfield
Therapeutic angiogenesis in critical limb and myocardial ischemia.
Journal of interventional cardiology 2001;14(5):511-28.
2001: Peter Vale; Douglas Losordo; James Symes; Jeffrey M Isner
[Growth factors for therapeutic angiogenesis in cardiovascular diseases].
Revista española de cardiología 2001;54(10):1210-24.
2001: David Goukassian; Antonio Díez-Juan; T Asahara; P Schratzberger; Marcy Silver; T Murayama; Jeffrey M Isner; Vicente Andrés
Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1877-85.
2001: Jeffrey M Isner; Peter Vale; James Symes; Douglas Losordo
Assessment of risks associated with cardiovascular gene therapy in human subjects.
Circulation research 2001;89(5):389-400.
2001: Jeffrey M Isner; A Ropper; K Hirst
VEGF gene transfer for diabetic neuropathy.
Human gene therapy 2001;12(12):1593-4.
2001: G Rauh; Anne Pieczek; W Irwin; Robert M Schainfeld; Jeffrey M Isner
In vivo analysis of intramuscular gene transfer in human subjects studied by on-line ultrasound imaging.
Human gene therapy 2001;12(12):1543-9.
2001: Joan Llevadot; Satoshi Murasawa; Y Kureishi; S Uchida; H Masuda; A Kawamoto; K Walsh; Jeffrey M Isner; Takayuki Asahara
HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells.
The Journal of clinical investigation 2001;108(3):399-405.
2001: Roberto Pola; Leona E Ling; Marcy Silver; M J Corbley; Marianne Kearney; R Blake Pepinsky; R Shapiro; Frederick R Taylor; Darren P Baker; Takayuki Asahara; Jeffrey M Isner
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.
Nature medicine 2001;7(6):706-11.
2001: D Simovic; Jeffrey M Isner; Allan H Ropper; A Pieczek; David H Weinberg
Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia.
Archives of neurology 2001;58(5):761-8.
2001: Peter Schratzberger; Dirk H Walter; Kilian Rittig; Ferdinand H Bahlmann; Roberto Pola; Cynthia Curry; Marcy Silver; J G Krainin; David H Weinberg; Allan H Ropper; Jeffrey M Isner
Reversal of experimental diabetic neuropathy by VEGF gene transfer.
The Journal of clinical investigation 2001;107(9):1083-92.
2001: Peter Vale; Douglas Losordo; Charles E Milliken; M C McDonald; L M Gravelin; C M Curry; DD Esakof; M Maysky; James Symes; Jeffrey M Isner
Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.
Circulation 2001;103(17):2138-43.
2001: Atsuhiko Kawamoto; H C Gwon; Hideki Iwaguro; Jun-ichi Yamaguchi; Shigeki Uchida; Haruchika Masuda; Marcy Silver; Hong Ma; Marianne Kearney; Jeffrey M Isner; Takayuki Asahara
Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia.
Circulation 2001;103(5):634-7.
2000: Karen A Vincent; K G Shyu; Yuxia Luo; M Magner; R A Tio; Canwen Jiang; Mark A Goldberg; Geoffrey Y Akita; Richard J Gregory; Jeffrey M Isner
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor.
Circulation 2000;102(18):2255-61.
2000: Alain Rivard; L Berthou-Soulie; Nicole Principe; Marianne Kearney; C Curry; Didier Branellec; Gregg L Semenza; Jeffrey M Isner
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity.
The Journal of biological chemistry 2000;275(38):29643-7.
2000: C Kalka; T Asahara; W Krone; Jeffrey M Isner
[Angiogenesis and vasculogenesis. Therapeutic strategies for stimulation of postnatal neovascularization].
Herz 2000;25(6):611-22.
2000: C Kalka; H Tehrani; B Laudenberg; Peter Vale; Jeffrey M Isner; T Asahara; James Symes
VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease.
The Annals of thoracic surgery 2000;70(3):829-34.
2000: Peter Vale; Douglas Losordo; Charles E Milliken; M Maysky; DD Esakof; James Symes; Jeffrey M Isner
Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia.
Circulation 2000;102(9):965-74.
2000: L Maillard; Eric Van Belle; FO Tio; Alain Rivard; Marianne Kearney; Didier Branellec; Philippe Gabriel STEG; Jeffrey M Isner; K Walsh
Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries.
Gene therapy 2000;7(16):1353-61.
2000: Christoph Kalka; Haruchika Masuda; Tomono Takahashi; R Gordon; Oren M Tepper; E Gravereaux; Anne Pieczek; Hideki Iwaguro; S I Hayashi; Jeffrey M Isner; Takayuki Asahara
Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects.
Circulation research 2000;86(12):1198-202.
2000: I Baumgartner; G Rauh; Anne Pieczek; D Wuensch; M Magner; Marianne Kearney; Robert M Schainfeld; Jeffrey M Isner
Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor.
Annals of internal medicine 2000;132(11):880-4.
2000: Peter Schratzberger; G Schratzberger; Marcy Silver; Cynthia Curry; Marianne Kearney; M Magner; J Alroy; Lester Adelman; David H Weinberg; A H Ropper; Jeffrey M Isner
Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy.
Nature medicine 2000;6(4):405-13.
2000: C Kalka; H Masuda; T Takahashi; W M Kalka-Moll; Marcy Silver; Marianne Kearney; T Li; Jeffrey M Isner; T Asahara
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3422-7.
2000: T Asahara; C Kalka; Jeffrey M Isner
Stem cell therapy and gene transfer for regeneration.
Gene therapy 2000;7(6):451-7.
2000: Kenneth Walsh; Jeffrey M Isner
Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall.
Cardiovascular research 2000;45(3):756-65.
2000: Robert Charles Hendel; Timothy D Henry; Krishna Rocha-Singh; Jeffrey M Isner; D J Kereiakes; Frank J Giordano; M Simons; R O Bonow
Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion: evidence for a dose-dependent effect.
Circulation 2000;101(2):118-21.
1999: Peter Vale; Douglas Losordo; Charles E Milliken; DD Esakof; Jeffrey M Isner
Images in Cardiovascular Medicine: Percutaneous myocardial gene transfer of phVEGF-2.
Circulation 1999;100(24):2462-3.
1999: R A Tio; T Tkebuchava; Thomas H. Scheuermann; C Lebherz; M Magner; M Kearny; DD Esakof; Jeffrey M Isner; James Symes
Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium.
Human gene therapy 1999;10(18):2953-60.
1999: DD Esakof; M Maysky; Douglas Losordo; Peter Vale; KG Lathi; J O Pastore; James Symes; Jeffrey M Isner
Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory angina pectoris.
Human gene therapy 1999;10(14):2307-14.
1999: James Symes; Douglas Losordo; Peter Vale; KG Lathi; DD Esakof; M Mayskiy; Jeffrey M Isner
Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease.
The Annals of thoracic surgery 1999;68(3):830-6; discussion 836-7.
1999: D Chen; K Guo; J Yang; W A Frazier; Jeffrey M Isner; V Andrés
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21(Cip1/WAF1).
The American journal of physiology 1999;277(3 Pt 2):H1100-6.
1999: D Chen; Takayuki Asahara; Kevin Krasinski; B Witzenbichler; J Yang; M Magner; Marianne Kearney; W A Frazier; Jeffrey M Isner; V Andrés
Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery.
Circulation 1999;100(8):849-54.
1999: Takayuki Asahara; H Masuda; T Takahashi; C Kalka; C Pastore; Marcy Silver; M Kearne; M Magner; Jeffrey M Isner
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization.
Circulation research 1999;85(3):221-8.
1999: Douglas Losordo; Peter Vale; Jeffrey M Isner
Gene therapy for myocardial angiogenesis.
American heart journal 1999;138(2 Pt 2):S132-41.
1999: Takayuki Asahara; Tomono Takahashi; Haruchika Masuda; Christoph Kalka; D Chen; Hideki Iwaguro; Y Inai; Marcy Silver; Jeffrey M Isner
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells.
The EMBO journal 1999;18(14):3964-72.
1999: Peter Vale; Douglas Losordo; Tengiz Tkebuchava; D Chen; Charles E Milliken; Jeffrey M Isner
Catheter-based myocardial gene transfer utilizing nonfluoroscopic electromechanical left ventricular mapping.
Journal of the American College of Cardiology 1999;34(1):246-54.
1999: thierry couffinhal; Marcy Silver; Marianne Kearney; A Sullivan; B Witzenbichler; M Magner; B Annex; K Peters; Jeffrey M Isner
Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-/- mice.
Circulation 1999;99(24):3188-98.
1999: JE Fabre; Alain Rivard; M Magner; Marcy Silver; Jeffrey M Isner
Tissue inhibition of angiotensin-converting enzyme activity stimulates angiogenesis in vivo.
Circulation 1999;99(23):3043-9.
1999: Toyoaki Murohara; B Witzenbichler; Ioakim Spyridopoulos; Takayuki Asahara; B Ding; A Sullivan; Douglas Losordo; Jeffrey M Isner
Role of endothelial nitric oxide synthase in endothelial cell migration.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1156-61.
1999: C Kalka; T Takahashi; H Masuda; T Asahara; Jeffrey M Isner
[Vascular endothelial factor (VEGF): therapeutic angiogenesis and vasculogenesis in the treatment of cardiovascular disease].
Medizinische Klinik (Munich, Germany : 1983) 1999;94(4):193-201.
1999: T Takahashi; C Kalka; H Masuda; D Chen; Marcy Silver; Marianne Kearney; M Magner; Jeffrey M Isner; Takayuki Asahara
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
Nature medicine 1999;5(4):434-8.
1999: Alain Rivard; Marcy Silver; D Chen; Marianne Kearney; M Magner; B Annex; K Peters; Jeffrey M Isner
Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.
The American journal of pathology 1999;154(2):355-63.
1999: Alain Rivard; JE Fabre; Marcy Silver; D Chen; Toyoaki Murohara; Marianne Kearney; M Magner; Takayuki Asahara; Jeffrey M Isner
Age-dependent impairment of angiogenesis.
Circulation 1999;99(1):111-20.
1998: Ioakim Spyridopoulos; Nicole Principe; Kevin Krasinski; Sh Xu; Marianne Kearney; M Magner; Jeffrey M Isner; Douglas Losordo
Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-alpha-induced apoptosis.
Circulation 1998;98(25):2883-90.
1998: Douglas Losordo; Peter Vale; James Symes; C H Dunnington; DD Esakof; M Maysky; A B Ashare; KG Lathi; Jeffrey M Isner
Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia.
Circulation 1998;98(25):2800-4.
1998: Jeffrey M Isner; I Baumgartner; G Rauh; Robert M Schainfeld; R Blair; O Manor; S Razvi; James Symes
Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: preliminary clinical results.
Journal of vascular surgery 1998;28(6):964-73; discussion 73-5.
1998: K G Shyu; O Manor; M Magner; G D Yancopoulos; Jeffrey M Isner
Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb.
Circulation 1998;98(19):2081-7.
1998: R A Tio; Jeffrey M Isner; K Walsh
Gene therapy to prevent restenosis, the Boston experience.
Seminars in interventional cardiology : SIIC 1998;3(3-4):205-10.
1998: Takayuki Asahara; D Chen; T Takahashi; K Fujikawa; Marianne Kearney; M Magner; G D Yancopoulos; Jeffrey M Isner
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.
Circulation research 1998;83(3):233-40.
1998: B Witzenbichler; Takayuki Asahara; Toyoaki Murohara; Marcy Silver; Ioakim Spyridopoulos; M Magner; Nicole Principe; Marianne Kearney; J S Hu; Jeffrey M Isner
Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia.
The American journal of pathology 1998;153(2):381-94.
1998: B Witzenbichler; P C Maisonpierre; P Jones; G D Yancopoulos; Jeffrey M Isner
Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.
The Journal of biological chemistry 1998;273(29):18514-21.
1998: Alain Rivard; Jeffrey M Isner
Angiogenesis and vasculogenesis in treatment of cardiovascular disease.
Molecular medicine (Cambridge, Mass.) 1998;4(7):429-40.
1998: thierry couffinhal; Marcy Silver; L P Zheng; Marianne Kearney; B Witzenbichler; Jeffrey M Isner
Mouse model of angiogenesis.
The American journal of pathology 1998;152(6):1667-79.
1998: T Murohara; T Asahara; Marcy Silver; C Bauters; H Masuda; C Kalka; Marianne Kearney; D Chen; James Symes; M C Fishman; P L Huang; Jeffrey M Isner
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
The Journal of clinical investigation 1998;101(11):2567-78.
1998: Eric Van Belle; L Maillard; Alain Rivard; JE Fabre; thierry couffinhal; Marianne Kearney; Didier Branellec; LJ Feldman; Kenneth Walsh; Jeffrey M Isner
Effects of poloxamer 407 on transfection time and percutaneous adenovirus-mediated gene transfer in native and stented vessels.
Human gene therapy 1998;9(7):1013-24.
1998: I Baumgartner; Anne Pieczek; O Manor; R Blair; Marianne Kearney; K Walsh; Jeffrey M Isner
Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia.
Circulation 1998;97(12):1114-23.
1998: Eric Van Belle; B Witzenbichler; D Chen; Marcy Silver; L Chang; R Schwall; Jeffrey M Isner
Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis.
Circulation 1998;97(4):381-90.
1998: R Riessen; M Kearney; J Lawler; Jeffrey M Isner
Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries.
American heart journal 1998;135(2 Pt 1):357-64.
1998: T Murohara; J R Horowitz; Marcy Silver; Yukio Tsurumi; D Chen; A Sullivan; Jeffrey M Isner
Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.
Circulation 1998;97(1):99-107.
1998: R van der Zee; T Murohara; J Passeri; M Kearney; D A Cheresh; Jeffrey M Isner
Reduced intimal thickening following alpha(v)beta3 blockade is associated with smooth muscle cell apoptosis.
Cell adhesion and communication 1998;6(5):371-9.
1998: Z Luo; T Asahara; Yukio Tsurumi; Jeffrey M Isner; James Symes
Reduction of vein graft intimal hyperplasia and preservation of endothelium-dependent relaxation by topical vascular endothelial growth factor.
Journal of vascular surgery 1998;27(1):167-73.
1997: Yukio Tsurumi; Marianne Kearney; D Chen; Marcy Silver; S Takeshita; J Yang; James Symes; Jeffrey M Isner
Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene.
Circulation 1997;96(9 Suppl):II-382-8.
1997: J R Horowitz; Alain Rivard; R van der Zee; M Hariawala; D D Sheriff; DD Esakof; G M Chaudhry; James Symes; Jeffrey M Isner
Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2793-800.
1997: Eric Van Belle; Alain Rivard; D Chen; Marcy Silver; S Bunting; N Ferrara; James Symes; C Bauters; Jeffrey M Isner
Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.
Circulation 1997;96(8):2667-74.
1997: Z Luo; M Diaco; T Murohara; N Ferrara; Jeffrey M Isner; James Symes
Vascular endothelial growth factor attenuates myocardial ischemia-reperfusion injury.
The Annals of thoracic surgery 1997;64(4):993-8.
1997: L Maillard; Eric Van Belle; Roy Smith; Aude Le-Roux; P Denéfle; G Steg; J J Barry; Didier Branellec; Jeffrey M Isner; Kenneth Walsh
Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty.
Cardiovascular research 1997;35(3):536-46.
1997: Yukio Tsurumi; Toyoaki Murohara; Kevin Krasinski; D Chen; B Witzenbichler; Marianne Kearney; thierry couffinhal; Jeffrey M Isner
Reciprocal relation between VEGF and NO in the regulation of endothelial integrity.
Nature medicine 1997;3(8):879-86.
1997: Roy Smith; Didier Branellec; David Henry Gorski; K Guo; H Perlman; Jean-François Dedieu; C Pastore; Abderrahim Mahfoudi; Patrice DENEFLE; Jeffrey M Isner; Kenneth Walsh
p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene.
Genes & development 1997;11(13):1674-89.
1997: Eric Van Belle; L Maillard; FO Tio; Jeffrey M Isner
Accelerated endothelialization by local delivery of recombinant human vascular endothelial growth factor reduces in-stent intimal formation.
Biochemical and biophysical research communications 1997;235(2):311-6.
1997: thierry couffinhal; Marianne Kearney; A Sullivan; M Silver; Yukio Tsurumi; Jeffrey M Isner
Histochemical staining following LacZ gene transfer underestimates transfection efficiency.
Human gene therapy 1997;8(8):929-34.
1997: Ioakim Spyridopoulos; Edi Brogi; Marianne Kearney; A B Sullivan; C Cetrulo; Jeffrey M Isner; Douglas Losordo
Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals.
Journal of molecular and cellular cardiology 1997;29(5):1321-30.
1997: Eric Van Belle; FO Tio; D Chen; L Maillard; D Chen; Marianne Kearney; Jeffrey M Isner
Passivation of metallic stents after arterial gene transfer of phVEGF165 inhibits thrombus formation and intimal thickening.
Journal of the American College of Cardiology 1997;29(6):1371-9.
1997: thierry couffinhal; Marianne Kearney; B Witzenbichler; D Chen; Toyoaki Murohara; Douglas Losordo; James Symes; Jeffrey M Isner
Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.
The American journal of pathology 1997;150(5):1673-85.
1997: Marianne Kearney; Anne Pieczek; L Haley; Douglas Losordo; V Andres; Robert M Schainfeld; Kenneth Rosenfield; Jeffrey M Isner
Histopathology of in-stent restenosis in patients with peripheral artery disease.
Circulation 1997;95(8):1998-2002.
1997: Sigrid Nikol; N Murakami; J G Pickering; Marianne Kearney; G Leclerc; B Höfling; Jeffrey M Isner; L Weir
Differential expression of nonmuscle myosin II isoforms in human atherosclerotic plaque.
Atherosclerosis 1997;130(1-2):71-85.
1997: H A Skopicki; G E Lyons; G Schatteman; Roy Smith; V Andrés; S Schirm; Jeffrey M Isner; Kenneth Walsh
Embryonic expression of the Gax homeodomain protein in cardiac, smooth, and skeletal muscle.
Circulation research 1997;80(4):452-62.
1997: Kevin Krasinski; I Spyridopoulos; Takayuki Asahara; R van der Zee; Jeffrey M Isner; Douglas Losordo
Estradiol accelerates functional endothelial recovery after arterial injury.
Circulation 1997;95(7):1768-72.
1997: I Spyridopoulos; A B Sullivan; Marianne Kearney; Jeffrey M Isner; Douglas Losordo
Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor.
Circulation 1997;95(6):1505-14.
1997: L J Feldman; C J Pastore; N Aubailly; Marianne Kearney; D Chen; Michel Perricaudet; Philippe Gabriel STEG; Jeffrey M Isner
Improved efficiency of arterial gene transfer by use of poloxamer 407 as a vehicle for adenoviral vectors.
Gene therapy 1997;4(3):189-98.
1997: G L Wei; Kevin Krasinski; Marianne Kearney; Jeffrey M Isner; Kenneth Walsh; V Andrés
Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty.
Circulation research 1997;80(3):418-26.
1997: R van der Zee; T Murohara; Z Luo; F Zollmann; J Passeri; C Lekutat; Jeffrey M Isner
Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium.
Circulation 1997;95(4):1030-7.
1997: Takayuki Asahara; Toyoaki Murohara; A Sullivan; Marcy Silver; R van der Zee; T Li; B Witzenbichler; G Schatteman; Jeffrey M Isner
Isolation of putative progenitor endothelial cells for angiogenesis.
Science (New York, N.Y.) 1997;275(5302):964-7.
1997: Kenneth Rosenfield; Robert M Schainfeld; Anne Pieczek; L Haley; Jeffrey M Isner
Restenosis of endovascular stents from stent compression.
Journal of the American College of Cardiology 1997;29(2):328-38.
1997: Eric Van Belle; FO Tio; thierry couffinhal; L Maillard; J Passeri; Jeffrey M Isner
Stent endothelialization. Time course, impact of local catheter delivery, feasibility of recombinant protein administration, and response to cytokine expedition.
Circulation 1997;95(2):438-48.
1996: Takayuki Asahara; D Chen; Yukio Tsurumi; Marianne Kearney; S Rossow; J Passeri; James Symes; Jeffrey M Isner
Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer.
Circulation 1996;94(12):3291-302.
1996: Yukio Tsurumi; S Takeshita; D Chen; Marianne Kearney; S T Rossow; J Passeri; J R Horowitz; James Symes; Jeffrey M Isner
Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion.
Circulation 1996;94(12):3281-90.
1996: S Rohovsky; M Kearney; Anne Pieczek; Kenneth Rosenfield; Robert M Schainfeld; Patricia A D'Amore; Jeffrey M Isner
Elevated levels of basic fibroblast growth factor in patients with limb ischemia.
American heart journal 1996;132(5):1015-9.
1996: S Takeshita; L Weir; D Chen; L P Zheng; R Riessen; C Bauters; James Symes; Napoleone Ferrara; Jeffrey M Isner
Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia.
Biochemical and biophysical research communications 1996;227(2):628-35.
1996: S Takeshita; Yukio Tsurumi; T Couffinahl; Takayuki Asahara; C Bauters; James Symes; Napoleone Ferrara; Jeffrey M Isner
Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):487-501.
1996: Takayuki Asahara; Yukio Tsurumi; S Takeshita; Jeffrey M Isner
Naked cDNA encoding secreted proteins for intra-arterial and intramuscular gene transfer.
Seminars in interventional cardiology : SIIC 1996;1(3):225-32.
1996: Jeffrey M Isner; Anne Pieczek; Robert M Schainfeld; R Blair; L Haley; Takayuki Asahara; Kenneth Rosenfield; S Razvi; K Walsh; James Symes
Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb.
Lancet 1996;348(9024):370-4.
1996: M D Hariawala; J R Horowitz; DD Esakof; D D Sheriff; D H Walter; BA Keyt; Jeffrey M Isner; James Symes
VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts.
The Journal of surgical research 1996;63(1):77-82.
1996: Jeffrey M Isner; K Walsh; Kenneth Rosenfield; Robert M Schainfeld; T Asahara; K Hogan; Anne Pieczek
Arterial gene therapy for restenosis.
Human gene therapy 1996;7(8):989-1011.
1996: Jeffrey M Isner; K Walsh; James Symes; Anne Pieczek; S Takeshita; J Lowry; Kenneth Rosenfield; L Weir; Edi Brogi; D Jurayj
Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery disease.
Human gene therapy 1996;7(8):959-88.
1996: R Riessen; T N Wight; C Pastore; C Henley; Jeffrey M Isner
Distribution of hyaluronan during extracellular matrix remodeling in human restenotic arteries and balloon-injured rat carotid arteries.
Circulation 1996;93(6):1141-7.
1996: J Geoffrey Pickering; S Takeshita; L Feldman; Douglas Losordo; Jeffrey M Isner
Vascular applications of human gene therapy.
Seminars in interventional cardiology : SIIC 1996;1(1):84-8.
1996: J Geoffrey Pickering; Jeffrey M Isner; C M Ford; L Weir; Andrew Lazarovits; E F Rocnik; LH Chow
Processing of chimeric antisense oligonucleotides by human vascular smooth muscle cells and human atherosclerotic plaque. Implications for antisense therapy of restenosis after angioplasty.
Circulation 1996;93(4):772-80.
1996: D H Walter; U Hink; Takayuki Asahara; Eric Van Belle; J Horowitz; Yukio Tsurumi; R Vandlen; H Heinsohn; BA Keyt; Napoleone Ferrara; James Symes; Jeffrey M Isner
The in vivo bioactivity of vascular endothelial growth factor/vascular permeability factor is independent of N-linked glycosylation.
Laboratory investigation; a journal of technical methods and pathology 1996;74(2):546-56.
1996: Edi Brogi; G Schatteman; T Wu; E A Kim; Lyuba Varticovski; B Keyt; Jeffrey M Isner
Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.
The Journal of clinical investigation 1996;97(2):469-76.
1996: Jeffrey M Isner
Therapeutic angiogenesis: a new frontier for vascular therapy.
Vascular medicine (London, England) 1996;1(1):79-87.
1996: Kenneth Rosenfield; Robert M Schainfeld; Jeffrey M Isner
Percutaneous revascularization in peripheral arterial disease.
Current problems in cardiology 1996;21(1):7-93.
1995: A Namiki; Edi Brogi; Marianne Kearney; E A Kim; T Wu; thierry couffinhal; Lyuba Varticovski; Jeffrey M Isner
Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells.
The Journal of biological chemistry 1995;270(52):31189-95.
1995: S Takeshita; S T Rossow; Marianne Kearney; L P Zheng; C Bauters; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency.
The American journal of pathology 1995;147(6):1649-60.
1995: Takayuki Asahara; C Bauters; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo.
Circulation 1995;92(9 Suppl):II365-71.
1995: L J Feldman; Jeffrey M Isner
Gene therapy for the vulnerable plaque.
Journal of the American College of Cardiology 1995;26(3):826-35.
1995: C J Pastore; Jeffrey M Isner; P A Bacha; Marianne Kearney; J Geoffrey Pickering
Epidermal growth factor receptor-targeted cytotoxin inhibits neointimal hyperplasia in vivo. Results of local versus systemic administration.
Circulation research 1995;77(3):519-29.
1995: L J Feldman; Philippe Gabriel STEG; L P Zheng; D Chen; Marianne Kearney; S E McGarr; J J Barry; J F Dedieu; Michel Perricaudet; Jeffrey M Isner
Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit.
The Journal of clinical investigation 1995;95(6):2662-71.
1995: C Bauters; Takayuki Asahara; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor.
Circulation 1995;91(11):2802-9.
1995: Takayuki Asahara; C Bauters; C Pastore; Marianne Kearney; S Rossow; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery.
Circulation 1995;91(11):2793-801.
1995: Jeffrey M Isner; Marianne Kearney; S Bortman; J Passeri
Apoptosis in human atherosclerosis and restenosis.
Circulation 1995;91(11):2703-11.
1995: Jeffrey M Isner; K Walsh; James Symes; Anne Pieczek; S Takeshita; J Lowry; S Rossow; Kenneth Rosenfield; L Weir; Edi Brogi
Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease.
Circulation 1995;91(11):2687-92.
1995: L Weir; D Chen; C Pastore; Jeffrey M Isner; Kenneth Walsh
Expression of gax, a growth arrest homeobox gene, is rapidly down-regulated in the rat carotid artery during the proliferative response to balloon injury.
The Journal of biological chemistry 1995;270(10):5457-61.
1995: C Bauters; Takayuki Asahara; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor.
Journal of vascular surgery 1995;21(2):314-24; discussion 324-5.
1994: Jeffrey M Isner; L J Feldman
Gene therapy for arterial disease.
Lancet 1994;344(8938):1653-4.
1994: S Takeshita; Lee L Q Pu; L A Stein; Allan D Sniderman; S Bunting; Napoleone Ferrara; Jeffrey M Isner; James Symes
Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia.
Circulation 1994;90(5 Pt 2):II228-34.
1994: C Bauters; Takayuki Asahara; L P Zheng; S Takeshita; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb.
The American journal of physiology 1994;267(4 Pt 2):H1263-71.
1994: Jeffrey M Isner; Marianne Kearney; C Bauters; G Leclerc; Sigrid Nikol; J Geoffrey Pickering; R Riessen; L Weir
Use of human tissue specimens obtained by directional atherectomy to study restenosis.
Trends in cardiovascular medicine 1994;4(5):213-21.
1994: S Takeshita; Douglas Losordo; Marianne Kearney; S T Rossow; Jeffrey M Isner
Time course of recombinant protein secretion after liposome-mediated gene transfer in a rabbit arterial organ culture model.
Laboratory investigation; a journal of technical methods and pathology 1994;71(3):387-91.
1994: Edi Brogi; T Wu; A Namiki; Jeffrey M Isner
Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.
Circulation 1994;90(2):649-52.
1994: Douglas Losordo; Kenneth Rosenfield; J Kaufman; Anne Pieczek; Jeffrey M Isner
Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. In vivo documentation using intravascular ultrasound.
Circulation 1994;89(6):2570-7.
1994: R Riessen; Jeffrey M Isner; E Blessing; C Loushin; Sigrid Nikol; T N Wight
Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries.
The American journal of pathology 1994;144(5):962-74.
1994: Douglas Losordo; Marianne Kearney; E A Kim; J Jekanowski; Jeffrey M Isner
Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.
Circulation 1994;89(4):1501-10.
1994: R Riessen; Jeffrey M Isner
Prospects for site-specific delivery of pharmacologic and molecular therapies.
Journal of the American College of Cardiology 1994;23(5):1234-44.
1994: Douglas Losordo; J Geoffrey Pickering; S Takeshita; G Leclerc; D Gal; L Weir; Marianne Kearney; J Jekanowski; Jeffrey M Isner
Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression.
Circulation 1994;89(2):785-92.
1994: S Takeshita; D Gal; G Leclerc; J Geoffrey Pickering; R Riessen; L Weir; Jeffrey M Isner
Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury.
The Journal of clinical investigation 1994;93(2):652-61.
1994: S Takeshita; L P Zheng; Edi Brogi; Marianne Kearney; Lee L Q Pu; S Bunting; Napoleone Ferrara; James Symes; Jeffrey M Isner
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.
The Journal of clinical investigation 1994;93(2):662-70.
1994: Jeffrey M Isner; Anne Pieczek; Kenneth Rosenfield
Images in cardiovascular medicine. Untreated gangrene in patients with peripheral artery disease.
Circulation 1994;89(1):482-3.
1994: J Geoffrey Pickering; J Jekanowski; L Weir; S Takeshita; Douglas Losordo; Jeffrey M Isner
Liposome-mediated gene transfer into human vascular smooth muscle cells.
Circulation 1994;89(1):13-21.
1994: K Hogan; K Ramaswamy; Douglas Losordo; Jeffrey M Isner
Pathology of mitral commissurotomy performed with the Inoue catheter: implications for mechanisms and complications.
Catheterization and cardiovascular diagnosis 1994;Suppl 2():42-51.
1993: R Riessen; H Rahimizadeh; E Blessing; S Takeshita; J J Barry; Jeffrey M Isner
Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon.
Human gene therapy 1993;4(6):749-58.
1993: Jeffrey M Isner; Kenneth Rosenfield
Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.
Circulation 1993;88(4 Pt 1):1534-57.
1993: Morris Mosseri; J Geoffrey Pickering; S Chokshi; D Gal; Jeffrey M Isner
Excimer laser-induced vasoreactivity.
European heart journal 1993;14(10):1394-403.
1993: Morris Mosseri; H J Fingert; Lyuba Varticovski; S Chokshi; Jeffrey M Isner
In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle.
Cancer research 1993;53(13):3028-33.
1993: Douglas Losordo; J O Pastore; D Coletta; D Kenny; Jeffrey M Isner
Limitations of color flow Doppler imaging in the quantification of valvular regurgitation: velocity of regurgitant jet, rather than volume, determines size of color Doppler image.
American heart journal 1993;126(1):168-76.
1993: Jeffrey M Isner; J Kaufman; Kenneth Rosenfield; Anne Pieczek; Robert M Schainfeld; K Ramaswamy; B D Kosowsky
Combined physiologic and anatomic assessment of percutaneous revascularization using a Doppler guidewire and ultrasound catheter.
The American journal of cardiology 1993;71(14):70D-86D.
1993: J Geoffrey Pickering; L Weir; J Jekanowski; M A Kearney; Jeffrey M Isner
Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization.
The Journal of clinical investigation 1993;91(4):1469-80.
1993: J Geoffrey Pickering; P A Bacha; L Weir; J Jekanowski; J C Nichols; Jeffrey M Isner
Prevention of smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor.
The Journal of clinical investigation 1993;91(2):724-9.
1993: D Gal; L Weir; G Leclerc; J Geoffrey Pickering; J Hogan; Jeffrey M Isner
Direct myocardial transfection in two animal models. Evaluation of parameters affecting gene expression and percutaneous gene delivery.
Laboratory investigation; a journal of technical methods and pathology 1993;68(1):18-25.
1992: Douglas Losordo; Kenneth Rosenfield; Anne Pieczek; K Baker; M Harding; Jeffrey M Isner
How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound.
Circulation 1992;86(6):1845-58.
1992: J Geoffrey Pickering; L Weir; Kenneth Rosenfield; J Stetz; J Jekanowski; Jeffrey M Isner
Smooth muscle cell outgrowth from human atherosclerotic plaque: implications for the assessment of lesion biology.
Journal of the American College of Cardiology 1992;20(6):1430-9.
1992: M Mecley; Kenneth Rosenfield; J Kaufman; R E Langevin; S Razvi; Jeffrey M Isner
Atherosclerotic plaque hemorrhage and rupture associated with crescendo claudication.
Annals of internal medicine 1992;117(8):663-6.
1992: Sigrid Nikol; Jeffrey M Isner; J Geoffrey Pickering; Marianne Kearney; G Leclerc; L Weir
Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.
The Journal of clinical investigation 1992;90(4):1582-92.
1992: Kenneth Rosenfield; J Kaufman; Anne Pieczek; R E Langevin; P E Palefski; S A Razvi; Jeffrey M Isner
Human coronary and peripheral arteries: on-line three-dimensional reconstruction from two-dimensional intravascular US scans. Work in progress.
Radiology 1992;184(3):823-32.
1992: G Leclerc; D Gal; S Takeshita; Sigrid Nikol; L Weir; Jeffrey M Isner
Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries.
The Journal of clinical investigation 1992;90(3):936-44.
1992: Kenneth Rosenfield; P Boffetti; J Kaufman; R Weinstein; S Razvi; Jeffrey M Isner
Three-dimensional reconstruction of human carotid arteries from images obtained during noninvasive B-mode ultrasound examination.
The American journal of cardiology 1992;70(3):379-84.
1992: Kenneth Rosenfield; J Kaufman; Anne Pieczek; R E Langevin; S Razvi; Jeffrey M Isner
Real-time three-dimensional reconstruction of intravascular ultrasound images of iliac arteries.
The American journal of cardiology 1992;70(3):412-5.
1992: Jeffrey M Isner; Kenneth Rosenfield; C J White; Stephen R Ramee; Marianne Kearney; Anne Pieczek; R E Langevin; S Razvi
In vivo assessment of vascular pathology resulting from laser irradiation. Analysis of 23 patients studied by directional atherectomy immediately after laser angioplasty.
Circulation 1992;85(6):2185-96.
1992: W A Dietz; J M Tobis; Jeffrey M Isner
Failure of angiography to accurately depict the extent of coronary artery narrowing in three fatal cases of percutaneous transluminal coronary angioplasty.
Journal of the American College of Cardiology 1992;19(6):1261-70.
1992: D Gal; S K Chokshi; Morris Mosseri; R H Clarke; Jeffrey M Isner
Percutaneous delivery of low-level laser energy reverses histamine-induced spasm in atherosclerotic Yucatan microswine.
Circulation 1992;85(2):756-68.
1991: Kenneth Rosenfield; Douglas Losordo; K Ramaswamy; J O Pastore; R E Langevin; S Razvi; B D Kosowsky; Jeffrey M Isner
Three-dimensional reconstruction of human coronary and peripheral arteries from images recorded during two-dimensional intravascular ultrasound examination.
Circulation 1991;84(5):1938-56.
1991: Jeffrey M Isner; Kenneth Rosenfield; Douglas Losordo; L Rose; R E Langevin; S Razvi; B D Kosowsky
Combination balloon-ultrasound imaging catheter for percutaneous transluminal angioplasty. Validation of imaging, analysis of recoil, and identification of plaque fracture.
Circulation 1991;84(2):739-54.
1991: Jeffrey M Isner
Acute catastrophic complications of balloon aortic valvuloplasty. The Mansfield Scientific Aortic Valvuloplasty Registry Investigators.
Journal of the American College of Cardiology 1991;17(6):1436-44.
1991: A R Lucas; T Gauthier; R H Clarke; Jeffrey M Isner
Angiographic contrast media interference with laser-induced fluorescence excitation and detection in atherosclerotic human coronary arteries.
American heart journal 1991;121(1 Pt 1):110-8.
1991: D Gal; J D Fonger; H Rastegar; S T DeJesus; R H Clarke; Jeffrey M Isner
Analysis of photoproducts, free radicals, and particulate debris generated during in vivo argon laser myoplasty.
Lasers in surgery and medicine 1991;11(2):125-32.
1990: Jeffrey M Isner; Kenneth Rosenfield; Douglas Losordo
Excimer laser atherectomy. The greening of Sisyphus.
Circulation 1990;81(6):2018-21.
1990: Natesa G Pandian; A Kreis; A Weintraub; A Motarjeme; M Desnoyers; Jeffrey M Isner; Marvin A Konstam; Deeb N Salem; V Millen
Real-time intravascular ultrasound imaging in humans.
The American journal of cardiology 1990;65(20):1392-6.
1990: Jeffrey M Isner; Douglas Losordo; Kenneth Rosenfield; K Ramaswamy; S Kelly; J O Pastore; B D Kosowsky
Catheter-based intravascular ultrasound discriminates bicuspid from tricuspid valves in adults with calcific aortic stenosis.
Journal of the American College of Cardiology 1990;15(6):1310-7.
1990: Jeffrey M Isner; S K Chokshi; A DeFranco; J Braimen; G A Slovenkai
Contrasting histoarchitecture of calcified leaflets from stenotic bicuspid versus stenotic tricuspid aortic valves.
Journal of the American College of Cardiology 1990;15(5):1104-8.
1990: Jeffrey M Isner; Kenneth Rosenfield; Douglas Losordo; S Kelly; P Palefski; R E Langevin; S Razvi; J O Pastore; B D Kosowsky
Percutaneous intravascular US as adjunct to catheter-based interventions: preliminary experience in patients with peripheral vascular disease.
Radiology 1990;175(1):61-70.
1990: C D Fields; G A Slovenkai; Jeffrey M Isner
Atrial septal defect resulting from mitral balloon valvuloplasty: relation of defect morphology to transseptal balloon catheter delivery.
American heart journal 1990;119(3 Pt 1):568-76.
1990: D Gal; A J Rongione; G A Slovenkai; S T DeJesus; A Lucas; C D Fields; Jeffrey M Isner
Atherosclerotic Yucatan microswine: an animal model with high-grade, fibrocalcific, nonfatty lesions suitable for testing catheter-based interventions.
American heart journal 1990;119(2 Pt 1):291-300.
1989: S K Chokshi; R Moore; N G Pandian; Jeffrey M Isner
Reversible cardiomyopathy associated with cocaine intoxication.
Annals of internal medicine 1989;111(12):1039-40.
1989: D Gal; Philippe Gabriel STEG; A J Rongione; S T DeJesus; R H Clarke; Jeffrey M Isner
Vascular spasm complicates continuous wave but not pulsed laser irradiation.
American heart journal 1989;118(5 Pt 1):934-41.
1989: P G Steg; A J Rongione; D Gal; S T Dejesus; Jeffrey M Isner
[Effects of continuous laser on arterial vasomotoricity in vitro].
Archives des maladies du coeur et des vaisseaux 1989;82(10):1753-8.
1989: Kenneth Rosenfield; S M Kelly; C D Fields; J O Pastore; R Weinstein; P Palefski; R E Langevin; B D Kosowsky; S Razvi; Jeffrey M Isner
Noninvasive assessment of peripheral vascular disease by color flow Doppler/two-dimensional ultrasound.
The American journal of cardiology 1989;64(3):247-51.
1989: P G Steg; A J Rongione; D Gal; S T DeJesus; R H Clarke; Jeffrey M Isner
Pulsed ultraviolet laser irradiation produces endothelium-independent relaxation of vascular smooth muscle.
Circulation 1989;80(1):189-97.
1989: Douglas Losordo; K Ramaswamy; Kenneth Rosenfield; Jeffrey M Isner
Use of emergency balloon dilation to reverse acute hemodynamic decompensation developing during diagnostic catheterization for aortic stenosis (bailout valvuloplasty).
The American journal of cardiology 1989;63(5):388-9.
1989: P G Steg; A J Rongione; D Gal; S T Dejesus; Jeffrey M Isner
[Effect of pulsed excimer laser on arterial smooth muscle].
Archives des maladies du coeur et des vaisseaux 1989;82(2):269-74.
1989: E J Gaffney; R H Clarke; A R Lucas; Jeffrey M Isner
Correlation of fluorescence emission with the plaque content and intimal thickness of atherosclerotic coronary arteries.
Lasers in surgery and medicine 1989;9(3):215-28.
1988: Jeffrey M Isner; W A Dietz
Cardiovascular consequences of recombinant DNA technology: interleukin-2.
Annals of internal medicine 1988;109(12):933-5.
1988: M R Desnoyers; Jeffrey M Isner; Natesa G Pandian; S S Wang; T Hougen; C D Fields; A R Lucas; Deeb N Salem
Clinical and noninvasive hemodynamic results after aortic balloon valvuloplasty for aortic stenosis.
The American journal of cardiology 1988;62(16):1078-84.
1988: P G Steg; D Gal; A J Rongione; S R DeJesus; R H Clarke; H J Levine; Jeffrey M Isner
Effect of argon laser irradiation on rabbit aortic smooth muscle: evidence for endothelium independent contraction and relaxation.
Cardiovascular research 1988;22(11):747-53.
1988: Natesa G Pandian; A Kreis; B Brockway; Jeffrey M Isner; A Sacharoff; E Boleza; R Caro; D Muller
Ultrasound angioscopy: real-time, two-dimensional, intraluminal ultrasound imaging of blood vessels.
The American journal of cardiology 1988;62(7):493-4.
1988: Jeffrey M Isner; A R Lucas; C D Fields
Laser therapy in the treatment of cardiovascular disease.
British journal of hospital medicine 1988;40(3):172-8.
1988: M R Desnoyers; Deeb N Salem; Kenneth Rosenfield; W Mackey; T O'Donnell; Jeffrey M Isner
Treatment of cardiogenic shock by emergency aortic balloon valvuloplasty.
Annals of internal medicine 1988;108(6):833-5.
1988: Jeffrey M Isner; Deeb N Salem; M R Desnoyers; C D Fields; K R Halaburka; G A Slovenkai; T J Hougen; E J Eichhorn; Kenneth Rosenfield
Dual balloon technique for valvuloplasty of aortic stenosis in adults.
The American journal of cardiology 1988;61(8):583-9.
1988: Jeffrey M Isner; D A Samuels; G A Slovenkai; K R Halaburka; T J Hougen; M R Desnoyers; C D Fields; Deeb N Salem
Mechanism of aortic balloon valvuloplasty: fracture of valvular calcific deposits.
Annals of internal medicine 1988;108(3):377-80.
1988: R H Clarke; Jeffrey M Isner; T Gauthier; K Nakagawa; F Cerio; E Hanlon; E Gaffney; E Rouse; S DeJesus
Spectroscopic characterization of cardiovascular tissue.
Lasers in surgery and medicine 1988;8(1):45-59.
1988: Jeffrey M Isner; S R DeJesus; R H Clarke; D Gal; A J Rongione; R F Donaldson
Mechanism of laser ablation in an absorbing fluid field.
Lasers in surgery and medicine 1988;8(6):543-54.
1988: Jeffrey M Isner
Excimer laser angioplasty: pygmalion makes it to the ball.
Lasers in surgery and medicine 1988;8(5):447-9.
1988: Jeffrey M Isner; D Gal; P G Steg; S T DeJesus; A J Rongione; K R Halaburka; G A Slovenkai; R H Clarke
Percutaneous, in vivo excimer laser angioplasty: results in two experimental animal models.
Lasers in surgery and medicine 1988;8(3):223-32.
1988: R H Clarke; K Nakagawa; Jeffrey M Isner
The production of short-lived free radicals accompanying laser photoablation of cardiovascular tissue.
Free radical biology & medicine 1988;4(4):209-13.
1987: D Gal; P G Steg; S T Dejesus; A J Rongione; R H Clarke; Jeffrey M Isner
Failure of angiography to diagnose thermal perforation complicating laser angioplasty in a rabbit.
The American journal of cardiology 1987;60(8):751-2.
1987: Jeffrey M Isner; R F Donaldson; D Fulton; I Bhan; Douglas D Payne; R J Cleveland
Cystic medial necrosis in coarctation of the aorta: a potential factor contributing to adverse consequences observed after percutaneous balloon angioplasty of coarctation sites.
Circulation 1987;75(4):689-95.
1987: R H Clarke; Jeffrey M Isner; R F Donaldson; G Jones
Gas chromatographic-light microscopic correlative analysis of excimer laser photoablation of cardiovascular tissues: evidence for a thermal mechanism.
Circulation research 1987;60(3):429-37.
1987: Jeffrey M Isner; N A Estes; Douglas D Payne; H Rastegar; R H Clarke; R J Cleveland
Laser-assisted endocardiectomy for refractory ventricular tachyarrhythmias: preliminary intraoperative experience.
Clinical cardiology 1987;10(3):201-4.
1987: Natesa G Pandian; Jeffrey M Isner; T J Hougen; M R Desnoyers; K McInerney; Deeb N Salem
Percutaneous balloon valvuloplasty of mitral stenosis aided by cardiac ultrasound.
The American journal of cardiology 1987;59(4):380-1.
1987: J D Kaplan; Jeffrey M Isner; R H Karas; K R Halaburka; Marvin A Konstam; T J Hougen; R J Cleveland; Deeb N Salem
In vitro analysis of mechanisms of balloon valvuloplasty of stenotic mitral valves.
The American journal of cardiology 1987;59(4):318-23.
1987: Jeffrey M Isner; Deeb N Salem; M R Desnoyers; T J Hougen; W C Mackey; Natesa G Pandian; E J Eichhorn; Marvin A Konstam; H J Levine
Treatment of calcific aortic stenosis by balloon valvuloplasty.
The American journal of cardiology 1987;59(4):313-7.
1986: Jeffrey M Isner; R F Donaldson; A H Fortin; A Tischler; R H Clarke
Attenuation of the media of coronary arteries in advanced atherosclerosis.
The American journal of cardiology 1986;58(10):937-9.
1986: L I Deckelbaum; Jeffrey M Isner; R F Donaldson; S M Laliberte; R H Clarke; Deeb N Salem
Use of pulsed energy delivery to minimize tissue injury resulting from carbon dioxide laser irradiation of cardiovascular tissues.
Journal of the American College of Cardiology 1986;7(4):898-908.
1985: Jeffrey M Isner; R F Donaldson; L I Deckelbaum; R H Clarke; S M Laliberte; A A Ucci; Deeb N Salem; M A Konstam
The excimer laser: gross, light microscopic and ultrastructural analysis of potential advantages for use in laser therapy of cardiovascular disease.
Journal of the American College of Cardiology 1985;6(5):1102-9.
1985: L I Deckelbaum; Jeffrey M Isner; R F Donaldson; R H Clarke; S Laliberte; A S Aharon; J S Bernstein
Reduction of laser-induced pathologic tissue injury using pulsed energy delivery.
The American journal of cardiology 1985;56(10):662-7.
1985: Jeffrey M Isner; R F Donaldson; J T Funai; L I Deckelbaum; N G Pandian; R H Clarke; M A Konstam; Deeb N Salem; J S Bernstein
Factors contributing to perforations resulting from laser coronary angioplasty: observations in an intact human postmortem preparation of intraoperative laser coronary angioplasty.
Circulation 1985;72(3 Pt 2):II191-9.
1985: Jeffrey M Isner; R H Clarke; R F Donaldson; A Aharon
Identification of photoproducts liberated by in vitro argon laser irradiation of atherosclerotic plaque, calcified cardiac valves and myocardium.
The American journal of cardiology 1985;55(9):1192-6.
1985: Jeffrey M Isner; H Michlewitz; R H Clarke; N A Estes; R F Donaldson; Deeb N Salem; I Bahn; Douglas D Payne; R J Cleveland
Laser photoablation of pathological endocardium: in vitro findings suggesting a new approach to the surgical treatment of refractory arrhythmias and restrictive cardiomyopathy.
The Annals of thoracic surgery 1985;39(3):201-6.
1985: Jeffrey M Isner; H Michlewitz; R H Clarke; R F Donaldson; M A Konstam; Deeb N Salem
Laser-assisted debridement of aortic valve calcium.
American heart journal 1985;109(3 Pt 1):448-52.
1984: Jeffrey M Isner; R H Clarke; N G Pandian; R F Donaldson; Deeb N Salem; M A Konstam; Douglas D Payne; R J Cleveland
Laser myoplasty for hypertrophic cardiomyopathy. In vitro experience in human postmortem hearts and in vivo experience in a canine model (transarterial) and human patient (intraoperative).
The American journal of cardiology 1984;53(11):1620-5.
1983: Jeffrey M Isner; B L Carter; M S Bankoff; J O Pastore; K Ramaswamy; K P McAdam; D N Salem
Differentiation of constrictive pericarditis from restrictive cardiomyopathy by computed tomographic imaging.
American heart journal 1983;105(6):1019-25.