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Jeffrey Isner

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Chemicals & Drugs

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Gene Transfer Techniques

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Publications

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Kirchmair Rudolf; Tietz Anne B; Panagiotou Eleftheria; Walter Dirk H; Silver Marcy; Yoon Young-Sup; Schratzberger Peter; Weber Alberto; Kusano Kengo; Weinberg David H; Ropper Allan H; Isner Jeffrey M; Losordo Douglas W
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
Witzenbichler Bernhard; Mahfoudi Abderrahim; Soubrier Fabienne; Le Roux Aude; Branellec Didier; Schultheiss Heinz-Peter; Isner Jeffrey M
Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model.
Kirchmair Rudolf; Walter Dirk H; Ii Masaaki; Rittig Kilian; Tietz Anne B; Murayama Toshinori; Emanueli Costanza; Silver Marcy; Wecker Andrea; Amant Carole; Schratzberger Peter; Yoon Young-Sup; Weber Alberto; Panagiotou Eleftheria; Rosen Kenneth M; Bahlmann Ferdinand H; Adelman Lester S; Weinberg David H; Ropper Allan H; Isner Jeffrey M; Losordo Douglas W
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.

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All Publications

2007: Kirchmair Rudolf; Tietz Anne B; Panagiotou Eleftheria; Walter Dirk H; Silver Marcy; Yoon Young-Sup; Schratzberger Peter; Weber Alberto; Kusano Kengo; Weinberg David H; Ropper Allan H; Isner Jeffrey M; Losordo Douglas W
Therapeutic angiogenesis inhibits or rescues chemotherapy-induced peripheral neuropathy: taxol- and thalidomide-induced injury of vasa nervorum is ameliorated by VEGF.
Molecular therapy : the journal of the American Society of Gene Therapy 2007;15(1):69-75.
2006: Witzenbichler Bernhard; Mahfoudi Abderrahim; Soubrier Fabienne; Le Roux Aude; Branellec Didier; Schultheiss Heinz-Peter; Isner Jeffrey M
Intramuscular gene transfer of fibroblast growth factor-1 using improved pCOR plasmid design stimulates collateral formation in a rabbit ischemic hindlimb model.
Journal of molecular medicine (Berlin, Germany) 2006;84(6):491-502.
2005: Kirchmair Rudolf; Walter Dirk H; Ii Masaaki; Rittig Kilian; Tietz Anne B; Murayama Toshinori; Emanueli Costanza; Silver Marcy; Wecker Andrea; Amant Carole; Schratzberger Peter; Yoon Young-Sup; Weber Alberto; Panagiotou Eleftheria; Rosen Kenneth M; Bahlmann Ferdinand H; Adelman Lester S; Weinberg David H; Ropper Allan H; Isner Jeffrey M; Losordo Douglas W
Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth.
Circulation 2005;111(20):2662-70.
2005: Hayashi Shin-ichiro; Asahara Takayuki; Masuda Haruchika; Isner Jeffrey M; Losordo Douglas W
Functional ephrin-B2 expression for promotive interaction between arterial and venous vessels in postnatal neovascularization.
Circulation 2005;111(17):2210-8.
2005: Yoon Young-sup; Uchida Shigeki; Masuo Osamu; Cejna Manfred; Park Jong-Seon; Gwon Hyeon-cheol; Kirchmair Rudolf; Bahlman Ferdinand; Walter Dirk; Curry Cynthia; Hanley Allison; Isner Jeffrey M; Losordo Douglas W
Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor.
Circulation 2005;111(16):2073-85.
2005: Bosch-Marcé Marta; Pola Roberto; Wecker Andrea B; Silver Marcy; Weber Alberto; Luedemann Corinne; Curry Cynthia; Murayama Toshinori; Kearney Marianne; Yoon Young-sup; Malinow M René; Asahara Takayuki; Isner Jeffrey M; Losordo Douglas W
Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia.
Vascular medicine (London, England) 2005;10(1):15-22.
2005: Reilly John P; Grise Mark A; Fortuin F David; Vale Peter R; Schaer Gary L; Lopez John; VAN Camp Joseph R; Henry Timothy; Richenbacher Wayne E; Losordo Douglas W; Schatz Richard A; Isner Jeffrey M
Long-term (2-year) clinical events following transthoracic intramyocardial gene transfer of VEGF-2 in no-option patients.
Journal of interventional cardiology 2005;18(1):27-31.
2004: Pola Roberto; Aprahamian Tamar R; Bosch-Marcé Marta; Curry Cynthia; Gaetani Eleonora; Flex Andrea; Smith Roy C; Isner Jeffrey M; Losordo Douglas W
Age-dependent VEGF expression and intraneural neovascularization during regeneration of peripheral nerves.
Neurobiology of aging 2004;25(10):1361-8.
2004: Walter Dirk H; Cejna Manfred; Diaz-Sandoval Larry; Willis Sean; Kirkwood Laura; Stratford Peter W; Tietz Anne B; Kirchmair Rudolf; Silver Marcy; Curry Cindy; Wecker Andrea; Yoon Young-Sup; Heidenreich Regina; Hanley Allison; Kearney Marianne; Tio Fermin O; Kuenzler Patrik; Isner Jeffrey M; Losordo Douglas W
Local gene transfer of phVEGF-2 plasmid by gene-eluting stents: an alternative strategy for inhibition of restenosis.
Circulation 2004;110(1):36-45.
2003: Iwakura Atsushi; Luedemann Corinne; Shastry Shubha; Hanley Allison; Kearney Marianne; Aikawa Ryuichi; Isner Jeffrey M; Asahara Takayuki; Losordo Douglas W
Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury.
Circulation 2003;108(25):3115-21.
2003: Fortuin F David; Vale Peter; Losordo Douglas W; Symes James; DeLaria Giacomo A; Tyner J Jeffrey; Schaer Gary L; March Robert; Snell R Jeffrey; Henry Timothy D; Van Camp Joseph; Lopez John J; Richenbacher Wayne; Isner Jeffrey M; Schatz Richard A
One-year follow-up of direct myocardial gene transfer of vascular endothelial growth factor-2 using naked plasmid deoxyribonucleic acid by way of thoracotomy in no-option patients.
The American journal of cardiology 2003;92(4):436-9.
2003: Pola Roberto; Ling Leona E; Aprahamian Tamar R; Barban Elena; Bosch-Marce Marta; Curry Cynthia; Corbley Michael; Kearney Marianne; Isner Jeffrey M; Losordo Douglas W
Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia.
Circulation 2003;108(4):479-85.
2003: Goukassian David A; Kishore Raj; Krasinski Kevin; Dolan Christine; Luedemann Corinne; Yoon Young-sup; Kearney Marianne; Hanley Allison; Ma Hong; Asahara Takayuki; Isner Jeffrey M; Losordo Douglas W
Engineering the response to vascular injury: divergent effects of deregulated E2F1 expression on vascular smooth muscle cells and endothelial cells result in endothelial recovery and inhibition of neointimal growth.
Circulation research 2003;93(2):162-9.
2003: Losordo Douglas W; Isner Jeffrey M; Diaz-Sandoval Larry J
Endothelial recovery: the next target in restenosis prevention.
Circulation 2003;107(21):2635-7.
2003: Shyu Kou-Gi; Chang Hang; Isner Jeffrey M
Synergistic effect of angiopoietin-1 and vascular endothelial growth factor on neoangiogenesis in hypercholesterolemic rabbit model with acute hindlimb ischemia.
Life sciences 2003;73(5):563-79.
2003: Yamaguchi Jun-ichi; Kusano Kengo Fukushima; Masuo Osamu; Kawamoto Atsuhiko; Silver Marcy; Murasawa Satoshi; Bosch-Marce Marta; Masuda Haruchika; Losordo Douglas W; Isner Jeffrey M; Asahara Takayuki
Stromal cell-derived factor-1 effects on ex vivo expanded endothelial progenitor cell recruitment for ischemic neovascularization.
Circulation 2003;107(9):1322-8.
2003: Yoon Young-Sup; Murayama Toshinori; Gravereaux Edwin; Tkebuchava Tengiz; Silver Marcy; Curry Cynthia; Wecker Andrea; Kirchmair Rudolf; Hu Chun Song; Kearney Marianne; Ashare Alan; Jackson David G; Kubo Hajime; Isner Jeffrey M; Losordo Douglas W
VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.
The Journal of clinical investigation 2003;111(5):717-25.
2003: Kawamoto Atsuhiko; Tkebuchava Tengis; Yamaguchi Jun-Ichi; Nishimura Hiromi; Yoon Young-Sup; Milliken Charles; Uchida Shigeki; Masuo Osamu; Iwaguro Hideki; Ma Hong; Hanley Allison; Silver Marcy; Kearney Marianne; Losordo Douglas W; Isner Jeffrey M; Asahara Takayuki
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia.
Circulation 2003;107(3):461-8.
2002: Schratzberger Peter; Krainin Joseph G; Schratzberger Gabriele; Silver Marcy; Ma Hong; Kearney Marianne; Zuk Robert F; Brisken Axel F; Losordo Douglas W; Isner Jeffrey M
Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(5):576-83.
2002: Freedman Saul Benedict; Vale Peter; Kalka Christoph; Kearney Marianne; Pieczek Anne; Symes James; Losordo Douglas; Isner Jeffrey M
Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA.
Human gene therapy 2002;13(13):1595-603.
2002: Murasawa Satoshi; Llevadot Joan; Silver Marcy; Isner Jeffrey M; Losordo Douglas W; Asahara Takayuki
Constitutive human telomerase reverse transcriptase expression enhances regenerative properties of endothelial progenitor cells.
Circulation 2002;106(9):1133-9.
2002: Walter Dirk H; Rittig Kilian; Bahlmann Ferdinand H; Kirchmair Rudolf; Silver Marcy; Murayama Toshinori; Nishimura Hiromi; Losordo Douglas W; Asahara Takayuki; Isner Jeffrey M
Statin therapy accelerates reendothelialization: a novel effect involving mobilization and incorporation of bone marrow-derived endothelial progenitor cells.
Circulation 2002;105(25):3017-24.
2002: Spyridopoulos Ioakim; Luedemann Corinne; Chen Donghui; Kearney Marianne; Chen Dongfen; Murohara Toyoaki; Principe Nicole; Isner Jeffrey M; Losordo Douglas W
Divergence of angiogenic and vascular permeability signaling by VEGF: inhibition of protein kinase C suppresses VEGF-induced angiogenesis, but promotes VEGF-induced, NO-dependent vascular permeability.
Arteriosclerosis, thrombosis, and vascular biology 2002;22(6):901-6.
2002: Asahara Takayuki; Isner Jeffrey M
Endothelial progenitor cells for vascular regeneration.
Journal of hematotherapy & stem cell research 2002;11(2):171-8.
2002: Losordo Douglas W; Vale Peter R; Hendel Robert C; Milliken Charles E; Fortuin F David; Cummings Nancie; Schatz Richard A; Asahara Takayuki; Isner Jeffrey M; Kuntz Richard E
Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia.
Circulation 2002;105(17):2012-8.
2002: Spyridopoulos Ioakim; Isner Jeffrey M; Losordo Douglas W
Oncogenic ras induces premature senescence in endothelial cells: role of p21(Cip1/Waf1).
Basic research in cardiology 2002;97(2):117-24.
2002: Iwaguro Hideki; Yamaguchi Jun-ichi; Kalka Christoph; Murasawa Satoshi; Masuda Haruchika; Hayashi Shin-ichiro; Silver Marcy; Li Tong; Isner Jeffrey M; Asahara Takayuki
Endothelial progenitor cell vascular endothelial growth factor gene transfer for vascular regeneration.
Circulation 2002;105(6):732-8.
2002: Bashir Riyaz; Vale Peter R; Isner Jeffrey M; Losordo Douglas W
Angiogenic gene therapy: pre-clinical studies and phase I clinical data.
Kidney international 2002;61(1 Suppl):S110-4.
2002: Isner Jeffrey M
Myocardial gene therapy.
Nature 2002;415(6868):234-9.
2002: Emanueli Costanza; Bonaria Salis Maria; Stacca Tiziana; Pintus Gianfranco; Kirchmair Rudolf; Isner Jeffrey M; Pinna Alessandra; Gaspa Leonardo; Regoli Domenico; Cayla Cecile; Pesquero João B; Bader Michael; Madeddu Paolo
Targeting kinin B(1) receptor for therapeutic neovascularization.
Circulation 2002;105(3):360-6.
2002: Freedman Saul Benedict; Isner Jeffrey M
Therapeutic angiogenesis for coronary artery disease.
Annals of internal medicine 2002;136(1):54-71.
2001: Henry T D; Rocha-Singh K; Isner J M; Kereiakes D J; Giordano F J; Simons M; Losordo D W; Hendel R C; Bonow R O; Eppler S M; Zioncheck T F; Holmgren E B; McCluskey E R
Intracoronary administration of recombinant human vascular endothelial growth factor to patients with coronary artery disease.
American heart journal 2001;142(5):872-80.
2001: Vale P R; Isner J M; Rosenfield K
Therapeutic angiogenesis in critical limb and myocardial ischemia.
Journal of interventional cardiology 2001;14(5):511-28.
2001: Vale P R; Losordo D W; Symes J F; Isner J M
[Growth factors for therapeutic angiogenesis in cardiovascular diseases]
Revista española de cardiología 2001;54(10):1210-24.
2001: Goukassian D; Díez-Juan A; Asahara T; Schratzberger P; Silver M; Murayama T; Isner J M; Andrés V
Overexpression of p27(Kip1) by doxycycline-regulated adenoviral vectors inhibits endothelial cell proliferation and migration and impairs angiogenesis.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001;15(11):1877-85.
2001: Isner J M; Vale P R; Symes J F; Losordo D W
Assessment of risks associated with cardiovascular gene therapy in human subjects.
Circulation research 2001;89(5):389-400.
2001: Isner J M; Ropper A; Hirst K
VEGF gene transfer for diabetic neuropathy.
Human gene therapy 2001;12(12):1593-4.
2001: Rauh G; Pieczek A; Irwin W; Schainfeld R; Isner J M
In vivo analysis of intramuscular gene transfer in human subjects studied by on-line ultrasound imaging.
Human gene therapy 2001;12(12):1543-9.
2001: Llevadot J; Murasawa S; Kureishi Y; Uchida S; Masuda H; Kawamoto A; Walsh K; Isner J M; Asahara T
HMG-CoA reductase inhibitor mobilizes bone marrow--derived endothelial progenitor cells.
The Journal of clinical investigation 2001;108(3):399-405.
2001: Pola R; Ling L E; Silver M; Corbley M J; Kearney M; Blake Pepinsky R; Shapiro R; Taylor F R; Baker D P; Asahara T; Isner J M
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors.
Nature medicine 2001;7(6):706-11.
2001: Simovic D; Isner J M; Ropper A H; Pieczek A; Weinberg D H
Improvement in chronic ischemic neuropathy after intramuscular phVEGF165 gene transfer in patients with critical limb ischemia.
Archives of neurology 2001;58(5):761-8.
2001: Schratzberger P; Walter D H; Rittig K; Bahlmann F H; Pola R; Curry C; Silver M; Krainin J G; Weinberg D H; Ropper A H; Isner J M
Reversal of experimental diabetic neuropathy by VEGF gene transfer.
The Journal of clinical investigation 2001;107(9):1083-92.
2001: Vale P R; Losordo D W; Milliken C E; McDonald M C; Gravelin L M; Curry C M; Esakof D D; Maysky M; Symes J F; Isner J M
Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia.
Circulation 2001;103(17):2138-43.
2001: Kawamoto A; Gwon H C; Iwaguro H; Yamaguchi J I; Uchida S; Masuda H; Silver M; Ma H; Kearney M; Isner J M; Asahara T
Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia.
Circulation 2001;103(5):634-7.
2000: Vincent K A; Shyu K G; Luo Y; Magner M; Tio R A; Jiang C; Goldberg M A; Akita G Y; Gregory R J; Isner J M
Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha/VP16 hybrid transcription factor.
Circulation 2000;102(18):2255-61.
2000: Kalka C; Asahara T; Krone W; Isner J M
[Angiogenesis and vasculogenesis. Therapeutic strategies for stimulation of postnatal neovascularization]
Herz 2000;25(6):611-22.
2000: Kalka C; Tehrani H; Laudenberg B; Vale P R; Isner J M; Asahara T; Symes J F
VEGF gene transfer mobilizes endothelial progenitor cells in patients with inoperable coronary disease.
The Annals of thoracic surgery 2000;70(3):829-34.
2000: Rivard A; Berthou-Soulie L; Principe N; Kearney M; Curry C; Branellec D; Semenza G L; Isner J M
Age-dependent defect in vascular endothelial growth factor expression is associated with reduced hypoxia-inducible factor 1 activity.
The Journal of biological chemistry 2000;275(38):29643-7.
2000: Maillard L; Van Belle E; Tio F O; Rivard A; Kearney M; Branellec D; Steg P G; Isner J M; Walsh K
Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries.
Gene therapy 2000;7(16):1353-61.
2000: Vale P R; Losordo D W; Milliken C E; Maysky M; Esakof D D; Symes J F; Isner J M
Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia.
Circulation 2000;102(9):965-74.
2000: Kalka C; Masuda H; Takahashi T; Gordon R; Tepper O; Gravereaux E; Pieczek A; Iwaguro H; Hayashi S I; Isner J M; Asahara T
Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects.
Circulation research 2000;86(12):1198-202.
2000: Baumgartner I; Rauh G; Pieczek A; Wuensch D; Magner M; Kearney M; Schainfeld R; Isner J M
Lower-extremity edema associated with gene transfer of naked DNA encoding vascular endothelial growth factor.
Annals of internal medicine 2000;132(11):880-4.
2000: Schratzberger P; Schratzberger G; Silver M; Curry C; Kearney M; Magner M; Alroy J; Adelman L S; Weinberg D H; Ropper A H; Isner J M
Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy.
Nature medicine 2000;6(4):405-13.
2000: Asahara T; Kalka C; Isner J M
Stem cell therapy and gene transfer for regeneration.
Gene therapy 2000;7(6):451-7.
2000: Kalka C; Masuda H; Takahashi T; Kalka-Moll W M; Silver M; Kearney M; Li T; Isner J M; Asahara T
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(7):3422-7.
2000: Walsh K; Isner J M
Apoptosis in inflammatory-fibroproliferative disorders of the vessel wall.
Cardiovascular research 2000;45(3):756-65.
2000: Hendel R C; Henry T D; Rocha-Singh K; Isner J M; Kereiakes D J; Giordano F J; Simons M; Bonow R O
Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion: evidence for a dose-dependent effect.
Circulation 2000;101(2):118-21.
1999: Tio R A; Tkebuchava T; Scheuermann T H; Lebherz C; Magner M; Kearny M; Esakof D D; Isner J M; Symes J F
Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium.
Human gene therapy 1999;10(18):2953-60.
1999: Vale P R; Losordo D W; Milliken C E; Esakof D D; Isner J M
Images in Cardiovascular Medicine: Percutaneous myocardial gene transfer of phVEGF-2.
Circulation 1999;100(24):2462-3.
1999: Esakof D D; Maysky M; Losordo D W; Vale P R; Lathi K; Pastore J O; Symes J F; Isner J M
Intraoperative multiplane transesophageal echocardiography for guiding direct myocardial gene transfer of vascular endothelial growth factor in patients with refractory angina pectoris.
Human gene therapy 1999;10(14):2307-14.
1999: Symes J F; Losordo D W; Vale P R; Lathi K G; Esakof D D; Mayskiy M; Isner J M
Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease.
The Annals of thoracic surgery 1999;68(3):830-6; discussion 836-7.
1999: Chen D; Guo K; Yang J; Frazier W A; Isner J M; Andrés V
Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21(Cip1/WAF1).
The American journal of physiology 1999;277(3 Pt 2):H1100-6.
1999: Chen D; Asahara T; Krasinski K; Witzenbichler B; Yang J; Magner M; Kearney M; Frazier W A; Isner J M; Andrés V
Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery.
Circulation 1999;100(8):849-54.
1999: Asahara T; Masuda H; Takahashi T; Kalka C; Pastore C; Silver M; Kearne M; Magner M; Isner J M
Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization.
Circulation research 1999;85(3):221-8.
1999: Losordo D W; Vale P R; Isner J M
Gene therapy for myocardial angiogenesis.
American heart journal 1999;138(2 Pt 2):S132-41.
1999: Asahara T; Takahashi T; Masuda H; Kalka C; Chen D; Iwaguro H; Inai Y; Silver M; Isner J M
VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells.
The EMBO journal 1999;18(14):3964-72.
1999: Vale P R; Losordo D W; Tkebuchava T; Chen D; Milliken C E; Isner J M
Catheter-based myocardial gene transfer utilizing nonfluoroscopic electromechanical left ventricular mapping.
Journal of the American College of Cardiology 1999;34(1):246-54.
1999: Couffinhal T; Silver M; Kearney M; Sullivan A; Witzenbichler B; Magner M; Annex B; Peters K; Isner J M
Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-/- mice.
Circulation 1999;99(24):3188-98.
1999: Fabre J E; Rivard A; Magner M; Silver M; Isner J M
Tissue inhibition of angiotensin-converting enzyme activity stimulates angiogenesis in vivo.
Circulation 1999;99(23):3043-9.
1999: Murohara T; Witzenbichler B; Spyridopoulos I; Asahara T; Ding B; Sullivan A; Losordo D W; Isner J M
Role of endothelial nitric oxide synthase in endothelial cell migration.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(5):1156-61.
1999: Kalka C; Takahashi T; Masuda H; Asahara T; Isner J M
[Vascular endothelial factor (VEGF): therapeutic angiogenesis and vasculogenesis in the treatment of cardiovascular disease]
Medizinische Klinik (Munich, Germany : 1983) 1999;94(4):193-201.
1999: Takahashi T; Kalka C; Masuda H; Chen D; Silver M; Kearney M; Magner M; Isner J M; Asahara T
Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization.
Nature medicine 1999;5(4):434-8.
1999: Rivard A; Silver M; Chen D; Kearney M; Magner M; Annex B; Peters K; Isner J M
Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.
The American journal of pathology 1999;154(2):355-63.
1999: Rivard A; Fabre J E; Silver M; Chen D; Murohara T; Kearney M; Magner M; Asahara T; Isner J M
Age-dependent impairment of angiogenesis.
Circulation 1999;99(1):111-20.
1998: Spyridopoulos I; Principe N; Krasinski K L; Xu Sh; Kearney M; Magner M; Isner J M; Losordo D W
Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-alpha-induced apoptosis.
Circulation 1998;98(25):2883-90.
1998: Losordo D W; Vale P R; Symes J F; Dunnington C H; Esakof D D; Maysky M; Ashare A B; Lathi K; Isner J M
Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia.
Circulation 1998;98(25):2800-4.
1998: Isner J M; Baumgartner I; Rauh G; Schainfeld R; Blair R; Manor O; Razvi S; Symes J F
Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: preliminary clinical results.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1998;28(6):964-73; discussion 73-5.
1998: Shyu K G; Manor O; Magner M; Yancopoulos G D; Isner J M
Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb.
Circulation 1998;98(19):2081-7.
1998: Tio R A; Isner J M; Walsh K
Gene therapy to prevent restenosis, the Boston experience.
Seminars in interventional cardiology : SIIC 1998;3(3-4):205-10.
1998: Asahara T; Chen D; Takahashi T; Fujikawa K; Kearney M; Magner M; Yancopoulos G D; Isner J M
Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.
Circulation research 1998;83(3):233-40.
1998: Witzenbichler B; Asahara T; Murohara T; Silver M; Spyridopoulos I; Magner M; Principe N; Kearney M; Hu J S; Isner J M
Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia.
The American journal of pathology 1998;153(2):381-94.
1998: Rivard A; Isner J M
Angiogenesis and vasculogenesis in treatment of cardiovascular disease.
Molecular medicine (Cambridge, Mass.) 1998;4(7):429-40.
1998: Witzenbichler B; Maisonpierre P C; Jones P; Yancopoulos G D; Isner J M
Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.
The Journal of biological chemistry 1998;273(29):18514-21.
1998: Couffinhal T; Silver M; Zheng L P; Kearney M; Witzenbichler B; Isner J M
Mouse model of angiogenesis.
The American journal of pathology 1998;152(6):1667-79.
1998: Murohara T; Asahara T; Silver M; Bauters C; Masuda H; Kalka C; Kearney M; Chen D; Symes J F; Fishman M C; Huang P L; Isner J M
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
The Journal of clinical investigation 1998;101(11):2567-78.
1998: Van Belle E; Maillard L; Rivard A; Fabre J E; Couffinhal T; Kearney M; Branellec D; Feldman L J; Walsh K; Isner J M
Effects of poloxamer 407 on transfection time and percutaneous adenovirus-mediated gene transfer in native and stented vessels.
Human gene therapy 1998;9(7):1013-24.
1998: Baumgartner I; Pieczek A; Manor O; Blair R; Kearney M; Walsh K; Isner J M
Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia.
Circulation 1998;97(12):1114-23.
1998: Riessen R; Kearney M; Lawler J; Isner J M
Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries.
American heart journal 1998;135(2 Pt 1):357-64.
1998: Van Belle E; Witzenbichler B; Chen D; Silver M; Chang L; Schwall R; Isner J M
Potentiated angiogenic effect of scatter factor/hepatocyte growth factor via induction of vascular endothelial growth factor: the case for paracrine amplification of angiogenesis.
Circulation 1998;97(4):381-90.
1998: Luo Z; Asahara T; Tsurumi Y; Isner J M; Symes J F
Reduction of vein graft intimal hyperplasia and preservation of endothelium-dependent relaxation by topical vascular endothelial growth factor.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1998;27(1):167-73.
1998: Murohara T; Horowitz J R; Silver M; Tsurumi Y; Chen D; Sullivan A; Isner J M
Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin.
Circulation 1998;97(1):99-107.
1998: van der Zee R; Murohara T; Passeri J; Kearney M; Cheresh D A; Isner J M
Reduced intimal thickening following alpha(v)beta3 blockade is associated with smooth muscle cell apoptosis.
Cell adhesion and communication 1998;6(5):371-9.
1997: Horowitz J R; Rivard A; van der Zee R; Hariawala M; Sheriff D D; Esakof D D; Chaudhry G M; Symes J F; Isner J M
Vascular endothelial growth factor/vascular permeability factor produces nitric oxide-dependent hypotension. Evidence for a maintenance role in quiescent adult endothelium.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(11):2793-800.
1997: Tsurumi Y; Kearney M; Chen D; Silver M; Takeshita S; Yang J; Symes J F; Isner J M
Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene.
Circulation 1997;96(9 Suppl):II-382-8.
1997: Van Belle E; Rivard A; Chen D; Silver M; Bunting S; Ferrara N; Symes J F; Bauters C; Isner J M
Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines.
Circulation 1997;96(8):2667-74.
1997: Luo Z; Diaco M; Murohara T; Ferrara N; Isner J M; Symes J F
Vascular endothelial growth factor attenuates myocardial ischemia-reperfusion injury.
The Annals of thoracic surgery 1997;64(4):993-8.
1997: Maillard L; Van Belle E; Smith R C; Le Roux A; Denéfle P; Steg G; Barry J J; Branellec D; Isner J M; Walsh K
Percutaneous delivery of the gax gene inhibits vessel stenosis in a rabbit model of balloon angioplasty.
Cardiovascular research 1997;35(3):536-46.
1997: Tsurumi Y; Murohara T; Krasinski K; Chen D; Witzenbichler B; Kearney M; Couffinhal T; Isner J M
Reciprocal relation between VEGF and NO in the regulation of endothelial integrity.
Nature medicine 1997;3(8):879-86.
1997: Smith R C; Branellec D; Gorski D H; Guo K; Perlman H; Dedieu J F; Pastore C; Mahfoudi A; Denèfle P; Isner J M; Walsh K
p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene.
Genes & development 1997;11(13):1674-89.
1997: Van Belle E; Maillard L; Tio F O; Isner J M
Accelerated endothelialization by local delivery of recombinant human vascular endothelial growth factor reduces in-stent intimal formation.
Biochemical and biophysical research communications 1997;235(2):311-6.
1997: Spyridopoulos I; Brogi E; Kearney M; Sullivan A B; Cetrulo C; Isner J M; Losordo D W
Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals.
Journal of molecular and cellular cardiology 1997;29(5):1321-30.
1997: Couffinhal T; Kearney M; Sullivan A; Silver M; Tsurumi Y; Isner J M
Histochemical staining following LacZ gene transfer underestimates transfection efficiency.
Human gene therapy 1997;8(8):929-34.
1997: Van Belle E; Tio F O; Chen D; Maillard L; Chen D; Kearney M; Isner J M
Passivation of metallic stents after arterial gene transfer of phVEGF165 inhibits thrombus formation and intimal thickening.
Journal of the American College of Cardiology 1997;29(6):1371-9.
1997: Couffinhal T; Kearney M; Witzenbichler B; Chen D; Murohara T; Losordo D W; Symes J; Isner J M
Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.
The American journal of pathology 1997;150(5):1673-85.
1997: Kearney M; Pieczek A; Haley L; Losordo D W; Andres V; Schainfeld R; Rosenfield K; Isner J M
Histopathology of in-stent restenosis in patients with peripheral artery disease.
Circulation 1997;95(8):1998-2002.
1997: Nikol S; Murakami N; Pickering J G; Kearney M; Leclerc G; Höfling B; Isner J M; Weir L
Differential expression of nonmuscle myosin II isoforms in human atherosclerotic plaque.
Atherosclerosis 1997;130(1-2):71-85.
1997: Skopicki H A; Lyons G E; Schatteman G; Smith R C; Andrés V; Schirm S; Isner J; Walsh K
Embryonic expression of the Gax homeodomain protein in cardiac, smooth, and skeletal muscle.
Circulation research 1997;80(4):452-62.
1997: Krasinski K; Spyridopoulos I; Asahara T; van der Zee R; Isner J M; Losordo D W
Estradiol accelerates functional endothelial recovery after arterial injury.
Circulation 1997;95(7):1768-72.
1997: Feldman L J; Pastore C J; Aubailly N; Kearney M; Chen D; Perricaudet M; Steg P G; Isner J M
Improved efficiency of arterial gene transfer by use of poloxamer 407 as a vehicle for adenoviral vectors.
Gene therapy 1997;4(3):189-98.
1997: Spyridopoulos I; Sullivan A B; Kearney M; Isner J M; Losordo D W
Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor.
Circulation 1997;95(6):1505-14.
1997: Wei G L; Krasinski K; Kearney M; Isner J M; Walsh K; Andrés V
Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty.
Circulation research 1997;80(3):418-26.
1997: van der Zee R; Murohara T; Luo Z; Zollmann F; Passeri J; Lekutat C; Isner J M
Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium.
Circulation 1997;95(4):1030-7.
1997: Asahara T; Murohara T; Sullivan A; Silver M; van der Zee R; Li T; Witzenbichler B; Schatteman G; Isner J M
Isolation of putative progenitor endothelial cells for angiogenesis.
Science (New York, N.Y.) 1997;275(5302):964-7.
1997: Rosenfield K; Schainfeld R; Pieczek A; Haley L; Isner J M
Restenosis of endovascular stents from stent compression.
Journal of the American College of Cardiology 1997;29(2):328-38.
1997: Van Belle E; Tio F O; Couffinhal T; Maillard L; Passeri J; Isner J M
Stent endothelialization. Time course, impact of local catheter delivery, feasibility of recombinant protein administration, and response to cytokine expedition.
Circulation 1997;95(2):438-48.
1996: Asahara T; Chen D; Tsurumi Y; Kearney M; Rossow S; Passeri J; Symes J F; Isner J M
Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer.
Circulation 1996;94(12):3291-302.
1996: Tsurumi Y; Takeshita S; Chen D; Kearney M; Rossow S T; Passeri J; Horowitz J R; Symes J F; Isner J M
Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion.
Circulation 1996;94(12):3281-90.
1996: Rohovsky S; Kearney M; Pieczek A; Rosenfield K; Schainfeld R; D'Amore P A; Isner J M
Elevated levels of basic fibroblast growth factor in patients with limb ischemia.
American heart journal 1996;132(5):1015-9.
1996: Takeshita S; Weir L; Chen D; Zheng L P; Riessen R; Bauters C; Symes J F; Ferrara N; Isner J M
Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia.
Biochemical and biophysical research communications 1996;227(2):628-35.
1996: Takeshita S; Tsurumi Y; Couffinahl T; Asahara T; Bauters C; Symes J; Ferrara N; Isner J M
Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo.
Laboratory investigation; a journal of technical methods and pathology 1996;75(4):487-501.
1996: Asahara T; Tsurumi Y; Takeshita S; Isner J M
Naked cDNA encoding secreted proteins for intra-arterial and intramuscular gene transfer.
Seminars in interventional cardiology : SIIC 1996;1(3):225-32.
1996: Isner J M; Pieczek A; Schainfeld R; Blair R; Haley L; Asahara T; Rosenfield K; Razvi S; Walsh K; Symes J F
Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb.
Lancet 1996;348(9024):370-4.
1996: Hariawala M D; Horowitz J R; Esakof D; Sheriff D D; Walter D H; Keyt B; Isner J M; Symes J F
VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts.
The Journal of surgical research 1996;63(1):77-82.
1996: Isner J M; Walsh K; Rosenfield K; Schainfeld R; Asahara T; Hogan K; Pieczek A
Arterial gene therapy for restenosis.
Human gene therapy 1996;7(8):989-1011.
1996: Isner J M; Walsh K; Symes J; Pieczek A; Takeshita S; Lowry J; Rosenfield K; Weir L; Brogi E; Jurayj D
Arterial gene transfer for therapeutic angiogenesis in patients with peripheral artery disease.
Human gene therapy 1996;7(8):959-88.
1996: Pickering J G; Takeshita S; Feldman L; Losordo D W; Isner J M
Vascular applications of human gene therapy.
Seminars in interventional cardiology : SIIC 1996;1(1):84-8.
1996: Riessen R; Wight T N; Pastore C; Henley C; Isner J M
Distribution of hyaluronan during extracellular matrix remodeling in human restenotic arteries and balloon-injured rat carotid arteries.
Circulation 1996;93(6):1141-7.
1996: Walter D H; Hink U; Asahara T; Van Belle E; Horowitz J; Tsurumi Y; Vandlen R; Heinsohn H; Keyt B; Ferrara N; Symes J F; Isner J M
The in vivo bioactivity of vascular endothelial growth factor/vascular permeability factor is independent of N-linked glycosylation.
Laboratory investigation; a journal of technical methods and pathology 1996;74(2):546-56.
1996: Pickering J G; Isner J M; Ford C M; Weir L; Lazarovits A; Rocnik E F; Chow L H
Processing of chimeric antisense oligonucleotides by human vascular smooth muscle cells and human atherosclerotic plaque. Implications for antisense therapy of restenosis after angioplasty.
Circulation 1996;93(4):772-80.
1996: Rosenfield K; Schainfeld R; Isner J M
Percutaneous revascularization in peripheral arterial disease.
Current problems in cardiology 1996;21(1):7-93.
1996: Brogi E; Schatteman G; Wu T; Kim E A; Varticovski L; Keyt B; Isner J M
Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression.
The Journal of clinical investigation 1996;97(2):469-76.
1996: Isner J M
Therapeutic angiogenesis: a new frontier for vascular therapy.
Vascular medicine (London, England) 1996;1(1):79-87.
1995: Namiki A; Brogi E; Kearney M; Kim E A; Wu T; Couffinhal T; Varticovski L; Isner J M
Hypoxia induces vascular endothelial growth factor in cultured human endothelial cells.
The Journal of biological chemistry 1995;270(52):31189-95.
1995: Takeshita S; Rossow S T; Kearney M; Zheng L P; Bauters C; Bunting S; Ferrara N; Symes J F; Isner J M
Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency.
The American journal of pathology 1995;147(6):1649-60.
1995: Asahara T; Bauters C; Zheng L P; Takeshita S; Bunting S; Ferrara N; Symes J F; Isner J M
Synergistic effect of vascular endothelial growth factor and basic fibroblast growth factor on angiogenesis in vivo.
Circulation 1995;92(9 Suppl):II365-71.
1995: Feldman L J; Isner J M
Gene therapy for the vulnerable plaque.
Journal of the American College of Cardiology 1995;26(3):826-35.
1995: Pastore C J; Isner J M; Bacha P A; Kearney M; Pickering J G
Epidermal growth factor receptor-targeted cytotoxin inhibits neointimal hyperplasia in vivo. Results of local versus systemic administration.
Circulation research 1995;77(3):519-29.
1995: Feldman L J; Steg P G; Zheng L P; Chen D; Kearney M; McGarr S E; Barry J J; Dedieu J F; Perricaudet M; Isner J M
Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit.
The Journal of clinical investigation 1995;95(6):2662-71.
1995: Bauters C; Asahara T; Zheng L P; Takeshita S; Bunting S; Ferrara N; Symes J F; Isner J M
Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor.
Circulation 1995;91(11):2802-9.
1995: Asahara T; Bauters C; Pastore C; Kearney M; Rossow S; Bunting S; Ferrara N; Symes J F; Isner J M
Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery.
Circulation 1995;91(11):2793-801.
1995: Isner J M; Kearney M; Bortman S; Passeri J
Apoptosis in human atherosclerosis and restenosis.
Circulation 1995;91(11):2703-11.
1995: Isner J M; Walsh K; Symes J; Pieczek A; Takeshita S; Lowry J; Rossow S; Rosenfield K; Weir L; Brogi E
Arterial gene therapy for therapeutic angiogenesis in patients with peripheral artery disease.
Circulation 1995;91(11):2687-92.
1995: Weir L; Chen D; Pastore C; Isner J M; Walsh K
Expression of gax, a growth arrest homeobox gene, is rapidly down-regulated in the rat carotid artery during the proliferative response to balloon injury.
The Journal of biological chemistry 1995;270(10):5457-61.
1995: Bauters C; Asahara T; Zheng L P; Takeshita S; Bunting S; Ferrara N; Symes J F; Isner J M
Site-specific therapeutic angiogenesis after systemic administration of vascular endothelial growth factor.
Journal of vascular surgery : official publication, the Society for Vascular Surgery [and] International Society for Cardiovascular Surgery, North American Chapter 1995;21(2):314-24; discussion 324-5.
1994: Isner J M; Feldman L J
Gene therapy for arterial disease.
Lancet 1994;344(8938):1653-4.
1994: Takeshita S; Pu L Q; Stein L A; Sniderman A D; Bunting S; Ferrara N; Isner J M; Symes J F
Intramuscular administration of vascular endothelial growth factor induces dose-dependent collateral artery augmentation in a rabbit model of chronic limb ischemia.
Circulation 1994;90(5 Pt 2):II228-34.
1994: Bauters C; Asahara T; Zheng L P; Takeshita S; Bunting S; Ferrara N; Symes J F; Isner J M
Physiological assessment of augmented vascularity induced by VEGF in ischemic rabbit hindlimb.
The American journal of physiology 1994;267(4 Pt 2):H1263-71.
1994: Takeshita S; Losordo D W; Kearney M; Rossow S T; Isner J M
Time course of recombinant protein secretion after liposome-mediated gene transfer in a rabbit arterial organ culture model.
Laboratory investigation; a journal of technical methods and pathology 1994;71(3):387-91.
1994: Brogi E; Wu T; Namiki A; Isner J M
Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression only.
Circulation 1994;90(2):649-52.
1994: Losordo D W; Rosenfield K; Kaufman J; Pieczek A; Isner J M
Focal compensatory enlargement of human arteries in response to progressive atherosclerosis. In vivo documentation using intravascular ultrasound.
Circulation 1994;89(6):2570-7.
1994: Riessen R; Isner J M; Blessing E; Loushin C; Nikol S; Wight T N
Regional differences in the distribution of the proteoglycans biglycan and decorin in the extracellular matrix of atherosclerotic and restenotic human coronary arteries.
The American journal of pathology 1994;144(5):962-74.
1994: Losordo D W; Kearney M; Kim E A; Jekanowski J; Isner J M
Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.
Circulation 1994;89(4):1501-10.
1994: Riessen R; Isner J M
Prospects for site-specific delivery of pharmacologic and molecular therapies.
Journal of the American College of Cardiology 1994;23(5):1234-44.
1994: Losordo D W; Pickering J G; Takeshita S; Leclerc G; Gal D; Weir L; Kearney M; Jekanowski J; Isner J M
Use of the rabbit ear artery to serially assess foreign protein secretion after site-specific arterial gene transfer in vivo. Evidence that anatomic identification of successful gene transfer may underestimate the potential magnitude of transgene expression.
Circulation 1994;89(2):785-92.
1994: Takeshita S; Gal D; Leclerc G; Pickering J G; Riessen R; Weir L; Isner J M
Increased gene expression after liposome-mediated arterial gene transfer associated with intimal smooth muscle cell proliferation. In vitro and in vivo findings in a rabbit model of vascular injury.
The Journal of clinical investigation 1994;93(2):652-61.
1994: Takeshita S; Zheng L P; Brogi E; Kearney M; Pu L Q; Bunting S; Ferrara N; Symes J F; Isner J M
Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.
The Journal of clinical investigation 1994;93(2):662-70.
1994: Isner J M; Pieczek A; Rosenfield K
Images in cardiovascular medicine. Untreated gangrene in patients with peripheral artery disease.
Circulation 1994;89(1):482-3.
1994: Pickering J G; Jekanowski J; Weir L; Takeshita S; Losordo D W; Isner J M
Liposome-mediated gene transfer into human vascular smooth muscle cells.
Circulation 1994;89(1):13-21.
1994: Hogan K; Ramaswamy K; Losordo D W; Isner J M
Pathology of mitral commissurotomy performed with the Inoue catheter: implications for mechanisms and complications.
Catheterization and cardiovascular diagnosis 1994;Suppl 2():42-51.
1993: Riessen R; Rahimizadeh H; Blessing E; Takeshita S; Barry J J; Isner J M
Arterial gene transfer using pure DNA applied directly to a hydrogel-coated angioplasty balloon.
Human gene therapy 1993;4(6):749-58.
1993: Isner J M; Rosenfield K
Redefining the treatment of peripheral artery disease. Role of percutaneous revascularization.
Circulation 1993;88(4 Pt 1):1534-57.
1993: Mosseri M; Pickering J G; Chokshi S; Gal D; Isner J M
Excimer laser-induced vasoreactivity.
European heart journal 1993;14(10):1394-403.
1993: Mosseri M; Fingert H J; Varticovski L; Chokshi S; Isner J M
In vitro evidence that myocardial ischemia resulting from 5-fluorouracil chemotherapy is due to protein kinase C-mediated vasoconstriction of vascular smooth muscle.
Cancer research 1993;53(13):3028-33.
1993: Losordo D W; Pastore J O; Coletta D; Kenny D; Isner J M
Limitations of color flow Doppler imaging in the quantification of valvular regurgitation: velocity of regurgitant jet, rather than volume, determines size of color Doppler image.
American heart journal 1993;126(1):168-76.
1993: Isner J M; Kaufman J; Rosenfield K; Pieczek A; Schainfeld R; Ramaswamy K; Kosowsky B D
Combined physiologic and anatomic assessment of percutaneous revascularization using a Doppler guidewire and ultrasound catheter.
The American journal of cardiology 1993;71(14):70D-86D.
1993: Pickering J G; Weir L; Jekanowski J; Kearney M A; Isner J M
Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization.
The Journal of clinical investigation 1993;91(4):1469-80.
1993: Pickering J G; Bacha P A; Weir L; Jekanowski J; Nichols J C; Isner J M
Prevention of smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor.
The Journal of clinical investigation 1993;91(2):724-9.
1993: Gal D; Weir L; Leclerc G; Pickering J G; Hogan J; Isner J M
Direct myocardial transfection in two animal models. Evaluation of parameters affecting gene expression and percutaneous gene delivery.
Laboratory investigation; a journal of technical methods and pathology 1993;68(1):18-25.
1992: Losordo D W; Rosenfield K; Pieczek A; Baker K; Harding M; Isner J M
How does angioplasty work? Serial analysis of human iliac arteries using intravascular ultrasound.
Circulation 1992;86(6):1845-58.
1992: Pickering J G; Weir L; Rosenfield K; Stetz J; Jekanowski J; Isner J M
Smooth muscle cell outgrowth from human atherosclerotic plaque: implications for the assessment of lesion biology.
Journal of the American College of Cardiology 1992;20(6):1430-9.
1992: Mecley M; Rosenfield K; Kaufman J; Langevin R E; Razvi S; Isner J M
Atherosclerotic plaque hemorrhage and rupture associated with crescendo claudication.
Annals of internal medicine 1992;117(8):663-6.
1992: Nikol S; Isner J M; Pickering J G; Kearney M; Leclerc G; Weir L
Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.
The Journal of clinical investigation 1992;90(4):1582-92.
1992: Rosenfield K; Kaufman J; Pieczek A M; Langevin R E; Palefski P E; Razvi S A; Isner J M
Human coronary and peripheral arteries: on-line three-dimensional reconstruction from two-dimensional intravascular US scans. Work in progress.
Radiology 1992;184(3):823-32.
1992: Leclerc G; Gal D; Takeshita S; Nikol S; Weir L; Isner J M
Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries.
The Journal of clinical investigation 1992;90(3):936-44.
1992: Rosenfield K; Boffetti P; Kaufman J; Weinstein R; Razvi S; Isner J M
Three-dimensional reconstruction of human carotid arteries from images obtained during noninvasive B-mode ultrasound examination.
The American journal of cardiology 1992;70(3):379-84.
1992: Rosenfield K; Kaufman J; Pieczek A; Langevin R E; Razvi S; Isner J M
Real-time three-dimensional reconstruction of intravascular ultrasound images of iliac arteries.
The American journal of cardiology 1992;70(3):412-5.
1992: Isner J M; Rosenfield K; White C J; Ramee S; Kearney M; Pieczek A; Langevin R E; Razvi S
In vivo assessment of vascular pathology resulting from laser irradiation. Analysis of 23 patients studied by directional atherectomy immediately after laser angioplasty.
Circulation 1992;85(6):2185-96.
1992: Dietz W A; Tobis J M; Isner J M
Failure of angiography to accurately depict the extent of coronary artery narrowing in three fatal cases of percutaneous transluminal coronary angioplasty.
Journal of the American College of Cardiology 1992;19(6):1261-70.
1992: Gal D; Chokshi S K; Mosseri M; Clarke R H; Isner J M
Percutaneous delivery of low-level laser energy reverses histamine-induced spasm in atherosclerotic Yucatan microswine.
Circulation 1992;85(2):756-68.
1991: Rosenfield K; Losordo D W; Ramaswamy K; Pastore J O; Langevin R E; Razvi S; Kosowsky B D; Isner J M
Three-dimensional reconstruction of human coronary and peripheral arteries from images recorded during two-dimensional intravascular ultrasound examination.
Circulation 1991;84(5):1938-56.
1991: Isner J M; Rosenfield K; Losordo D W; Rose L; Langevin R E; Razvi S; Kosowsky B D
Combination balloon-ultrasound imaging catheter for percutaneous transluminal angioplasty. Validation of imaging, analysis of recoil, and identification of plaque fracture.
Circulation 1991;84(2):739-54.
1991: Isner J M
Acute catastrophic complications of balloon aortic valvuloplasty. The Mansfield Scientific Aortic Valvuloplasty Registry Investigators.
Journal of the American College of Cardiology 1991;17(6):1436-44.
1991: Lucas A R; Gauthier T; Clarke R H; Isner J M
Angiographic contrast media interference with laser-induced fluorescence excitation and detection in atherosclerotic human coronary arteries.
American heart journal 1991;121(1 Pt 1):110-8.
1991: Gal D; Fonger J D; Rastegar H; DeJesus S T; Clarke R H; Isner J M
Analysis of photoproducts, free radicals, and particulate debris generated during in vivo argon laser myoplasty.
Lasers in surgery and medicine 1991;11(2):125-32.
1990: Isner J M; Rosenfield K; Losordo D W
Excimer laser atherectomy. The greening of Sisyphus.
Circulation 1990;81(6):2018-21.
1990: Pandian N G; Kreis A; Weintraub A; Motarjeme A; Desnoyers M; Isner J M; Konstam M; Salem D N; Millen V
Real-time intravascular ultrasound imaging in humans.
The American journal of cardiology 1990;65(20):1392-6.
1990: Isner J M; Losordo D W; Rosenfield K; Ramaswamy K; Kelly S; Pastore J O; Kosowsky B D
Catheter-based intravascular ultrasound discriminates bicuspid from tricuspid valves in adults with calcific aortic stenosis.
Journal of the American College of Cardiology 1990;15(6):1310-7.
1990: Isner J M; Chokshi S K; DeFranco A; Braimen J; Slovenkai G A
Contrasting histoarchitecture of calcified leaflets from stenotic bicuspid versus stenotic tricuspid aortic valves.
Journal of the American College of Cardiology 1990;15(5):1104-8.
1990: Isner J M; Rosenfield K; Losordo D W; Kelly S; Palefski P; Langevin R E; Razvi S; Pastore J O; Kosowsky B D
Percutaneous intravascular US as adjunct to catheter-based interventions: preliminary experience in patients with peripheral vascular disease.
Radiology 1990;175(1):61-70.
1990: Fields C D; Slovenkai G A; Isner J M
Atrial septal defect resulting from mitral balloon valvuloplasty: relation of defect morphology to transseptal balloon catheter delivery.
American heart journal 1990;119(3 Pt 1):568-76.
1990: Gal D; Rongione A J; Slovenkai G A; DeJesus S T; Lucas A; Fields C D; Isner J M
Atherosclerotic Yucatan microswine: an animal model with high-grade, fibrocalcific, nonfatty lesions suitable for testing catheter-based interventions.
American heart journal 1990;119(2 Pt 1):291-300.
1989: Chokshi S K; Moore R; Pandian N G; Isner J M
Reversible cardiomyopathy associated with cocaine intoxication.
Annals of internal medicine 1989;111(12):1039-40.
1989: Gal D; Steg P G; Rongione A J; DeJesus S T; Clarke R H; Isner J M
Vascular spasm complicates continuous wave but not pulsed laser irradiation.
American heart journal 1989;118(5 Pt 1):934-41.
1989: Steg P G; Rongione A J; Gal D; Dejesus S T; Isner J M
[Effects of continuous laser on arterial vasomotoricity in vitro]
Archives des maladies du coeur et des vaisseaux 1989;82(10):1753-8.
1989: Steg P G; Rongione A J; Gal D; DeJesus S T; Clarke R H; Isner J M
Pulsed ultraviolet laser irradiation produces endothelium-independent relaxation of vascular smooth muscle.
Circulation 1989;80(1):189-97.
1989: Rosenfield K; Kelly S M; Fields C D; Pastore J O; Weinstein R; Palefski P; Langevin R E; Kosowsky B D; Razvi S; Isner J M
Noninvasive assessment of peripheral vascular disease by color flow Doppler/two-dimensional ultrasound.
The American journal of cardiology 1989;64(3):247-51.
1989: Losordo D W; Ramaswamy K; Rosenfield K; Isner J M
Use of emergency balloon dilation to reverse acute hemodynamic decompensation developing during diagnostic catheterization for aortic stenosis (bailout valvuloplasty).
The American journal of cardiology 1989;63(5):388-9.
1989: Steg P G; Rongione A J; Gal D; Dejesus S T; Isner J M
[Effect of pulsed excimer laser on arterial smooth muscle]
Archives des maladies du coeur et des vaisseaux 1989;82(2):269-74.
1989: Gaffney E J; Clarke R H; Lucas A R; Isner J M
Correlation of fluorescence emission with the plaque content and intimal thickness of atherosclerotic coronary arteries.
Lasers in surgery and medicine 1989;9(3):215-28.
1988: Isner J M; Dietz W A
Cardiovascular consequences of recombinant DNA technology: interleukin-2.
Annals of internal medicine 1988;109(12):933-5.
1988: Steg P G; Gal D; Rongione A J; DeJesus S R; Clarke R H; Levine H J; Isner J M
Effect of argon laser irradiation on rabbit aortic smooth muscle: evidence for endothelium independent contraction and relaxation.
Cardiovascular research 1988;22(11):747-53.
1988: Desnoyers M R; Isner J M; Pandian N G; Wang S S; Hougen T; Fields C D; Lucas A R; Salem D N
Clinical and noninvasive hemodynamic results after aortic balloon valvuloplasty for aortic stenosis.
The American journal of cardiology 1988;62(16):1078-84.
1988: Pandian N G; Kreis A; Brockway B; Isner J M; Sacharoff A; Boleza E; Caro R; Muller D
Ultrasound angioscopy: real-time, two-dimensional, intraluminal ultrasound imaging of blood vessels.
The American journal of cardiology 1988;62(7):493-4.
1988: Isner J M; Lucas A R; Fields C D
Laser therapy in the treatment of cardiovascular disease.
British journal of hospital medicine 1988;40(3):172-8.
1988: Desnoyers M R; Salem D N; Rosenfield K; Mackey W; O'Donnell T; Isner J M
Treatment of cardiogenic shock by emergency aortic balloon valvuloplasty.
Annals of internal medicine 1988;108(6):833-5.
1988: Isner J M; Salem D N; Desnoyers M R; Fields C D; Halaburka K R; Slovenkai G A; Hougen T J; Eichhorn E J; Rosenfield K
Dual balloon technique for valvuloplasty of aortic stenosis in adults.
The American journal of cardiology 1988;61(8):583-9.
1988: Isner J M; Samuels D A; Slovenkai G A; Halaburka K R; Hougen T J; Desnoyers M R; Fields C D; Salem D N
Mechanism of aortic balloon valvuloplasty: fracture of valvular calcific deposits.
Annals of internal medicine 1988;108(3):377-80.
1988: Clarke R H; Isner J M; Gauthier T; Nakagawa K; Cerio F; Hanlon E; Gaffney E; Rouse E; DeJesus S
Spectroscopic characterization of cardiovascular tissue.
Lasers in surgery and medicine 1988;8(1):45-59.
1988: Isner J M; DeJesus S R; Clarke R H; Gal D; Rongione A J; Donaldson R F
Mechanism of laser ablation in an absorbing fluid field.
Lasers in surgery and medicine 1988;8(6):543-54.
1988: Isner J M
Excimer laser angioplasty: pygmalion makes it to the ball.
Lasers in surgery and medicine 1988;8(5):447-9.
1988: Isner J M; Gal D; Steg P G; DeJesus S T; Rongione A J; Halaburka K R; Slovenkai G A; Clarke R H
Percutaneous, in vivo excimer laser angioplasty: results in two experimental animal models.
Lasers in surgery and medicine 1988;8(3):223-32.
1988: Clarke R H; Nakagawa K; Isner J M
The production of short-lived free radicals accompanying laser photoablation of cardiovascular tissue.
Free radical biology & medicine 1988;4(4):209-13.
1987: Gal D; Steg P G; Dejesus S T; Rongione A J; Clarke R H; Isner J M
Failure of angiography to diagnose thermal perforation complicating laser angioplasty in a rabbit.
The American journal of cardiology 1987;60(8):751-2.
1987: Isner J M; Donaldson R F; Fulton D; Bhan I; Payne D D; Cleveland R J
Cystic medial necrosis in coarctation of the aorta: a potential factor contributing to adverse consequences observed after percutaneous balloon angioplasty of coarctation sites.
Circulation 1987;75(4):689-95.
1987: Clarke R H; Isner J M; Donaldson R F; Jones G
Gas chromatographic-light microscopic correlative analysis of excimer laser photoablation of cardiovascular tissues: evidence for a thermal mechanism.
Circulation research 1987;60(3):429-37.
1987: Isner J M; Estes N A; Payne D D; Rastegar H; Clarke R H; Cleveland R J
Laser-assisted endocardiectomy for refractory ventricular tachyarrhythmias: preliminary intraoperative experience.
Clinical cardiology 1987;10(3):201-4.
1987: Pandian N G; Isner J M; Hougen T J; Desnoyers M R; McInerney K; Salem D N
Percutaneous balloon valvuloplasty of mitral stenosis aided by cardiac ultrasound.
The American journal of cardiology 1987;59(4):380-1.
1987: Kaplan J D; Isner J M; Karas R H; Halaburka K R; Konstam M A; Hougen T J; Cleveland R J; Salem D N
In vitro analysis of mechanisms of balloon valvuloplasty of stenotic mitral valves.
The American journal of cardiology 1987;59(4):318-23.
1987: Isner J M; Salem D N; Desnoyers M R; Hougen T J; Mackey W C; Pandian N G; Eichhorn E J; Konstam M A; Levine H J
Treatment of calcific aortic stenosis by balloon valvuloplasty.
The American journal of cardiology 1987;59(4):313-7.
1986: Isner J M; Donaldson R F; Fortin A H; Tischler A; Clarke R H
Attenuation of the media of coronary arteries in advanced atherosclerosis.
The American journal of cardiology 1986;58(10):937-9.
1986: Deckelbaum L I; Isner J M; Donaldson R F; Laliberte S M; Clarke R H; Salem D N
Use of pulsed energy delivery to minimize tissue injury resulting from carbon dioxide laser irradiation of cardiovascular tissues.
Journal of the American College of Cardiology 1986;7(4):898-908.
1985: Isner J M; Donaldson R F; Deckelbaum L I; Clarke R H; Laliberte S M; Ucci A A; Salem D N; Konstam M A
The excimer laser: gross, light microscopic and ultrastructural analysis of potential advantages for use in laser therapy of cardiovascular disease.
Journal of the American College of Cardiology 1985;6(5):1102-9.
1985: Deckelbaum L I; Isner J M; Donaldson R F; Clarke R H; Laliberte S; Aharon A S; Bernstein J S
Reduction of laser-induced pathologic tissue injury using pulsed energy delivery.
The American journal of cardiology 1985;56(10):662-7.
1985: Isner J M; Donaldson R F; Funai J T; Deckelbaum L I; Pandian N G; Clarke R H; Konstam M A; Salem D N; Bernstein J S
Factors contributing to perforations resulting from laser coronary angioplasty: observations in an intact human postmortem preparation of intraoperative laser coronary angioplasty.
Circulation 1985;72(3 Pt 2):II191-9.
1985: Isner J M; Clarke R H; Donaldson R F; Aharon A
Identification of photoproducts liberated by in vitro argon laser irradiation of atherosclerotic plaque, calcified cardiac valves and myocardium.
The American journal of cardiology 1985;55(9):1192-6.
1985: Isner J M; Michlewitz H; Clarke R H; Estes N A; Donaldson R F; Salem D N; Bahn I; Payne D D; Cleveland R J
Laser photoablation of pathological endocardium: in vitro findings suggesting a new approach to the surgical treatment of refractory arrhythmias and restrictive cardiomyopathy.
The Annals of thoracic surgery 1985;39(3):201-6.
1985: Isner J M; Michlewitz H; Clarke R H; Donaldson R F; Konstam M A; Salem D N
Laser-assisted debridement of aortic valve calcium.
American heart journal 1985;109(3 Pt 1):448-52.
1984: Isner J M; Clarke R H; Pandian N G; Donaldson R F; Salem D N; Konstam M A; Payne D D; Cleveland R J
Laser myoplasty for hypertrophic cardiomyopathy. In vitro experience in human postmortem hearts and in vivo experience in a canine model (transarterial) and human patient (intraoperative).
The American journal of cardiology 1984;53(11):1620-5.
1983: Isner J M; Carter B L; Bankoff M S; Pastore J O; Ramaswamy K; McAdam K P; Salem D N
Differentiation of constrictive pericarditis from restrictive cardiomyopathy by computed tomographic imaging.
American heart journal 1983;105(6):1019-25.

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