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Ken-Ichi Isobe

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Zhao Cheng; He Fang; Sachiko Ito; Naomi Nishio; Suganya Thanasegaran; Ken-Ichi Isobe
Characteristics of cardiac aging in C57BL/6 mice.
Mohammad Nizam Uddin; Sachiko Ito; Naomi Nishio; Haruhiko Suzuki; Ken-Ichi Isobe
Autophagic activity in thymus and liver during aging.
Ken-Ichi Isobe; Sachiko Ito; Zhao Cheng; Naomi Nishio
Aging in the mouse and perspectives of rejuvenation through induced pluripotent stem cells (iPSCs).

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2013: Zhao Cheng; He Fang; Sachiko Ito; Naomi Nishio; Suganya Thanasegaran; Ken-Ichi Isobe
Characteristics of cardiac aging in C57BL/6 mice.
Experimental gerontology 2013;48(3):341-8.
2012: Mohammad Nizam Uddin; Sachiko Ito; Naomi Nishio; Haruhiko Suzuki; Ken-Ichi Isobe
Autophagic activity in thymus and liver during aging.
Age (Dordrecht, Netherlands) 2012;34(1):75-85.
2012: Ken-Ichi Isobe; Sachiko Ito; Zhao Cheng; Naomi Nishio
Aging in the mouse and perspectives of rejuvenation through induced pluripotent stem cells (iPSCs).
Results and problems in cell differentiation 2012;55():413-27.
2012: Hirohiko Suzuki; Takashi Yamamoto; Naomi Nishio; Rei Shibata; Masakazu Ishii; Ken-Ichi Isobe; Sachiko Ito; Tetsutaro Kito; Toyoaki Murohara
Comparative angiogenic activities of induced pluripotent stem cells derived from young and old mice.
PloS one 2012;7(6):e39562.
2012: Ken-Ichi Isobe; Herman S Cheung; Ji Wu
Toward personalized cell therapies by using stem cells.
Journal of biomedicine & biotechnology 2012;2012():172564.
2011: R Zhang; Seiji Ito; N Nishio; Z Cheng; Haruhiko Suzuki; Ken-Ichi Isobe
Dextran sulphate sodium increases splenic Gr1(+)CD11b(+) cells which accelerate recovery from colitis following intravenous transplantation.
Clinical and experimental immunology 2011;164(3):417-27.
2011: Mohammad Nizam Uddin; Sachiko Ito; Naomi Nishio; Thanasegaran Suganya; Ken-Ichi Isobe
Gadd34 induces autophagy through the suppression of the mTOR pathway during starvation.
Biochemical and biophysical research communications 2011;407(4):692-8.
2011: Zhao Cheng; Sachiko Ito; Naomi Nishio; Hengyi Xiao; Rong Zhang; Haruhiko Suzuki; Yayoi Okawa; Toyoaki Murohara; Ken-Ichi Isobe
Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells.
Journal of molecular cell biology 2011;3(2):91-8.
2011: Rong Zhang; Sachiko Ito; Naomi Nishio; Zhao Cheng; Haruhiko Suzuki; Ken-Ichi Isobe
Up-regulation of Gr1+CD11b+ population in spleen of dextran sulfate sodium administered mice works to repair colitis.
Inflammation & allergy drug targets 2011;10(1):39-46.
2011: Yuta Inami; Tohru Yoshikai; Sachiko Ito; Naomi Nishio; Haruhiko Suzuki; Hidetoshi Sakurai; Ken-Ichi Isobe
Differentiation of induced pluripotent stem cells to thymic epithelial cells by phenotype.
Immunology and cell biology 2011;89(2):314-21.
2010: Chie Tanaka; Sachiko Ito; Naomi Nishio; Yasuhiro Kodera; Hidetoshi Sakurai; Haruhiko Suzuki; Akimasa Nakao; Ken-Ichi Isobe
GADD34 suppresses wound healing by upregulating expression of myosin IIA.
Transgenic research 2010;19(4):637-45.
2010: Mohammad Nizam Uddin; Naomi Nishio; Sachiko Ito; Haruhiko Suzuki; Ken-Ichi Isobe
Toxic effects of D-galactose on thymus and spleen that resemble aging.
Journal of immunotoxicology 2010;7(3):165-73.
2010: Daisuke Hida; Naoki Ishiguro; Masataka Haneda; Yoshiyuki Ishida; Haruhiko Suzuki; Ken-Ichi Isobe
Intra-bone marrow bone marrow transplantation rejuvenates the B-cell lineage in aged mice.
Immunology and cell biology 2010;88(1):87-94.
2009: Hidetoshi Sakurai; Yuta Inami; Yukie Tamamura; Toru Yoshikai; Atsuko Sehara-Fujisawa; Ken-Ichi Isobe
Bidirectional induction toward paraxial mesodermal derivatives from mouse ES cells in chemically defined medium.
Stem cell research 2009;3(2-3):157-69.
2009: Zhe Shi; Yusuke Okuno; Muhaimin Rifa'i; Agustina Tri Endharti; Kazuyuki Akane; Ken-Ichi Isobe; Haruhiko Suzuki
Human CD8+CXCR3+ T cells have the same function as murine CD8+CD122+ Treg.
European journal of immunology 2009;39(8):2106-19.
2009: Hideaki Ishikawa; Sachiko Ito; Naomi Nishio; Yukio Yuzawa; Sei-Ichi Matsuo; Ken-Ichi Isobe
Injection of bleomycin in newborn mice induces autoimmune sialitis that is transferred by CD4 T cells.
Immunology and cell biology 2009;87(4):351-8.
2009: Naoki Matsumoto; Mina Okochi; Miyoko Matsushima; Akiko Ogawa; Tomokazu Takase; Yasuko Yoshida; Mitsuo Kawase; Ken-Ichi Isobe; Tsutomu Kawabe; Hiroyuki Honda
Development of peptide arrays for detection of IgE-binding epitopes in cow's milk allergens.
Journal of bioscience and bioengineering 2009;107(3):324-30.
2008: Norio Yoshida; Kazuhiko Ino; Yoshiyuki Ishida; Hiroaki Kajiyama; Eiko Yamamoto; Kiyosumi Shibata; Mikio Terauchi; Akihiro Nawa; Hidetoshi Akimoto; Osamu Takikawa; Ken-Ichi Isobe; Fumitaka Kikkawa
Overexpression of indoleamine 2,3-dioxygenase in human endometrial carcinoma cells induces rapid tumor growth in a mouse xenograft model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(22):7251-9.
2008: Haruhiko Suzuki; Zhe Shi; Yusuke Okuno; Ken-Ichi Isobe
Are CD8+CD122+ cells regulatory T cells or memory T cells?
Human immunology 2008;69(11):751-4.
2008: Shin Sasaki; Yoshiyuki Ishida; Naomi Nishio; Sachiko Ito; Ken-Ichi Isobe
Thymic involution correlates with severe ulcerative colitis induced by oral administration of dextran sulphate sodium in C57BL/6 mice but not in BALB/c mice.
Inflammation 2008;31(5):319-28.
2008: Muhaimin Rifa'i; Zhe Shi; Shu-Yun Zhang; Young Ho Lee; Hiroshi Shiku; Ken-Ichi Isobe; Haruhiko Suzuki
CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells.
International immunology 2008;20(7):937-47.
2008: Zhe Shi; Muhaimin Rifa'i; Young Ho Lee; Hiroshi Shiku; Ken-Ichi Isobe; Haruhiko Suzuki
Importance of CD80/CD86-CD28 interactions in the recognition of target cells by CD8+CD122+ regulatory T cells.
Immunology 2008;124(1):121-8.
2008: Toshiaki Hara; Fumiyuki Yamakura; Osamu Takikawa; Rie Hiramatsu; Tsutomu Kawabe; Ken-Ichi Isobe; Fumihiko Nagase
Diazotization of kynurenine by acidified nitrite secreted from indoleamine 2,3-dioxygenase-expressing myeloid dendritic cells.
Journal of immunological methods 2008;332(1-2):162-9.
2008: Naomi Nishio; Yayoi Okawa; Hidetoshi Sakurai; Ken-Ichi Isobe
Neutrophil depletion delays wound repair in aged mice.
Age (Dordrecht, Netherlands) 2008;30(1):11-9.
2008: Toshiaki Hara; Nanako Ogasawara; Hidetoshi Akimoto; Osamu Takikawa; Rie Hiramatsu; Tsutomu Kawabe; Ken-Ichi Isobe; Fumihiko Nagase
High-affinity uptake of kynurenine and nitric oxide-mediated inhibition of indoleamine 2,3-dioxygenase in bone marrow-derived myeloid dendritic cells.
Immunology letters 2008;116(1):95-102.
2008: Rie Hiramatsu; Toshiaki Hara; Hidetoshi Akimoto; Osamu Takikawa; Tsutomu Kawabe; Ken-Ichi Isobe; Fumihiko Nagase
Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase.
Journal of cellular biochemistry 2008;103(1):42-53.
2007: Yoshiyuki Ishida; Yayoi Okawa; Sachiko Ito; Tetsuya Shirokawa; Ken-Ichi Isobe
Age-dependent changes in dopaminergic projections from the substantia nigra pars compacta to the neostriatum.
Neuroscience letters 2007;418(3):257-61.
2006: Ken-Ichi Isobe; Sachiko Ito; Masataka Haneda; Yoshiyuki Ishida
Cellular and systemic defense system against age-promoting stimuli.
Nagoya journal of medical science 2006;68(1-2):9-18.
2005: Agustina Tri Endharti; Muhaimin Rifa'i; Zhe Shi; Yukari Fukuoka; Yoshio Nakahara; Yoshiyuki Kawamoto; Kozue Takeda; Ken-Ichi Isobe; Haruhiko Suzuki
Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(11):7093-7.
2005: Sachiko Ito; Makoto Sawada; Masataka Haneda; Satoshi Fujii; Kentaro Oh-Hashi; Kazutoshi Kiuchi; Masahide Takahashi; Ken-Ichi Isobe
Amyloid-beta peptides induce cell proliferation and macrophage colony-stimulating factor expression via the PI3-kinase/Akt pathway in cultured Ra2 microglial cells.
FEBS letters 2005;579(9):1995-2000.
2004: Natsuko Uekawa; Akihiko Nishikimi; Ken-Ichi Isobe; Yoichiro Iwakura; Mitsuo Maruyama
Involvement of IL-1 family proteins in p38 linked cellular senescence of mouse embryonic fibroblasts.
FEBS letters 2004;575(1-3):30-4.
2004: Masataka Haneda; Hengyi Xiao; Tadao Hasegawa; Yuko Kimura; Izumi Nakashima; Ken-Ichi Isobe
Regulation of mouse GADD34 gene transcription after DNA damaging agent methylmethane sulfonate.
Gene 2004;336(1):139-46.
2003: Ayako Yagi; Yoshinori Hasegawa; Hengyi Xiao; Masataka Haneda; Eiji Kojima; Akihiko Nishikimi; Tadao Hasegawa; Kaoru Shimokata; Ken-Ichi Isobe
GADD34 induces p53 phosphorylation and p21/WAF1 transcription.
Journal of cellular biochemistry 2003;90(6):1242-9.
2002: Koji Yamamoto; Takayoshi Shimokawa; Hong Yi; Ken-Ichi Isobe; Tetsuhito Kojima; David J Loskutoff; Hidehiko Saito
Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse.
Blood 2002;100(12):4011-8.
2002: Kayoko Maehara; Natsuko Uekawa; Ken-Ichi Isobe
Effects of histone acetylation on transcriptional regulation of manganese superoxide dismutase gene.
Biochemical and biophysical research communications 2002;295(1):187-92.
2001: Yoshiyuki Ishida; Tetsuya Shirokawa; Y Komatsu; Ken-Ichi Isobe
Changes in cortical noradrenergic axon terminals of locus coeruleus neurons in aged F344 rats.
Neuroscience letters 2001;307(3):197-9.
2001: Yoshiyuki Ishida; Tetsuya Shirokawa; O Miyaishi; Y Komatsu; Ken-Ichi Isobe
Age-dependent changes in noradrenergic innervations of the frontal cortex in F344 rats.
Neurobiology of aging 2001;22(2):283-6.
2000: Tetsuya Shirokawa; Yoshiyuki Ishida; Ken-Ichi Isobe
Age-dependent changes in axonal branching of single locus coeruleus neurons projecting to two different terminal fields.
Journal of neurophysiology 2000;84(2):1120-2.
2000: Tetsuya Shirokawa; Yoshiyuki Ishida; Ken-Ichi Isobe
Changes in electrophysiological properties of axon terminals of locus coeruleus neurons with age in F344 rat.
Neuroscience letters 2000;289(1):69-71.
2000: Yoshiyuki Ishida; Tetsuya Shirokawa; O Miyaishi; Y Komatsu; Ken-Ichi Isobe
Age-dependent changes in projections from locus coeruleus to hippocampus dentate gyrus and frontal cortex.
The European journal of neuroscience 2000;12(4):1263-70.
1999: K Ohkusu-Tsukada; T Tsukada; Ken-Ichi Isobe
Accelerated development and aging of the immune system in p53-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(4):1966-72.
1998: A Takeuchi; Ken-Ichi Isobe; O Miyaishi; M Sawada; ZH Fan; Izumi Nakashima; K Kiuchi
Microglial NO induces delayed neuronal death following acute injury in the striatum.
The European journal of neuroscience 1998;10(5):1613-20.
1997: K Ohkusu; Jun Du; Ken-Ichi Isobe; H Yi; Anwarul A Akhand; Masashi Kato; Haruhiko Suzuki; H Hidaka; Izumi Nakashima
Protein kinase C alpha-mediated chronic signal transduction for immunosenescence.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2082-4.
1997: Keiya Aono; Ken-Ichi Isobe; K Kiuchi; ZH Fan; M Ito; A Takeuchi; M Miyachi; Izumi Nakashima; Yuji Nimura
In vitro and in vivo expression of inducible nitric oxide synthase during experimental endotoxemia: involvement of other cytokines.
Journal of cellular biochemistry 1997;65(3):349-58.
1997: Y Nozaki; Yoshinori Hasegawa; A Takeuchi; ZH Fan; Ken-Ichi Isobe; Izumi Nakashima; Kaoru Shimokata
Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats.
The American journal of physiology 1997;272(4 Pt 1):L651-8.
1996: Z Heidari; Ken-Ichi Isobe; K Kiuchi; S Goto; I Nakashima; Y Tomoda
Promotion of proliferation of murine hematopoietic stem cells by growth factors in murine amniotic fluid.
Journal of reproductive immunology 1996;31(1-2):51-64.
1996: H Sano; M Hirai; H Saito; I Nakashima; Ken-Ichi Isobe
Nitric oxide releasing reagent, S-nitroso-N-acetylpenicillamine, enhances the expression of manganese superoxide dismutase mRNA in rat vascular smooth muscle cells.
Journal of cellular biochemistry 1996;62(1):50-5.
1996: C Koike; Ken-Ichi Isobe; I Nakashima; Hidechika Okada; Shuji Hayashi; Itsuo Yokoyama; H Takagi
How can human DAF and HRF20 prevent HAR in transgenic mice?
Transplantation proceedings 1996;28(2):599-600.
1996: Shuji Hayashi; Nobuhiko Emi; Ken-Ichi Isobe; Itsuo Yokoyama; Hidechika Okada; H Takagi
Inhibitory effect of double transfection to xenoendothelial cells using both decay accelerating factor and homologous restriction factor 20 genes on complement dependent cytolysis.
The Journal of surgical research 1996;61(1):165-9.
1996: C Koike; Ken-Ichi Isobe; I Nakashima; Hidechika Okada; Shuji Hayashi; Itsuo Yokoyama; H Takagi
Establishment of a human DAF/HRF20 double transgenic mouse line is not sufficient to suppress hyperacute rejection.
Surgery today 1996;26(12):993-8.
1996: H Yi; I Nakashima; Ken-Ichi Isobe
Enhancement of nitric oxide production from activated macrophages by glycyrrhizin.
The American journal of Chinese medicine 1996;24(3-4):271-8.
1996: Shuji Hayashi; Ken-Ichi Isobe; Nobuhiko Emi; Itsuo Yokoyama; Hidechika Okada; I Nakashima; H Takagi
Inhibition of human complement-dependent cell lysis by bovine aortic endothelial cells transfected with membrane-bound complement-regulatory factor (DAF and HRF20) gene using a retroviral vector.
European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes 1996;28(6):440-6.
1996: Z Heidari; Ken-Ichi Isobe; S Goto; I Nakashima; K Kiuchi; Y Tomoda
Characterization of the growth factor activity of amniotic fluid on cells from hematopoietic and lymphoid organs of different life stages.
Microbiology and immunology 1996;40(8):583-9.
1996: H Morita; Ken-Ichi Isobe; Z Cai; T Miyazaki; Y Matsumoto; Takahiro Shinzato; Yasunobu Yoshikai; K Kimata; K Maeda
Thy-1 antigen mediates apoptosis of rat glomerular cells in vitro and in vivo.
Nephron 1996;73(2):293-8.
1995: K Ohkusu; Ken-Ichi Isobe; H Hidaka; I Nakashima
Elucidation of the protein kinase C-dependent apoptosis pathway in distinct subsets of T lymphocytes in MRL-lpr/lpr mice.
European journal of immunology 1995;25(11):3180-6.
1995: K Inoi; S Goto; Seiji Nomura; Ken-Ichi Isobe; Akihiro Nawa; Tomomitsu Okamoto; Y Tomoda
Aminopeptidase inhibitor ubenimex (bestatin) inhibits the growth of human choriocarcinoma in nude mice through its direct cytostatic activity.
Anticancer research 1995;15(5B):2081-7.
1995: L Ma; M Y Pu; H Yi; Anwarul A Akhand; N Ohata; K Ohkusu; Masashi Kato; T Iwamoto; Ken-Ichi Isobe; Michinari Hamaguchi
Multiphasic modulation of signal transduction into T lymphocytes by monoiodoacetic acid as a sulfhydryl reagent.
Journal of cellular biochemistry 1995;59(1):33-41.
1995: H Nishikage; Lajos Baranyi; Hidechika Okada; Noriko Okada; Ken-Ichi Isobe; A Nomura; F Yoshida; Seiichi Matsuo
The role of a complement regulatory protein in rat mesangial glomerulonephritis.
Journal of the American Society of Nephrology : JASN 1995;6(2):234-41.
1995: Y H Zhang; Masashi Kato; Ken-Ichi Isobe; Michinari Hamaguchi; Takashi Yokochi; I Nakashima
Dissociated control by glycyrrhizin of proliferation and IL-2 production of murine thymocytes.
Cellular immunology 1995;162(1):97-104.
1995: Masatoshi Ichihara; T Iwamoto; Ken-Ichi Isobe; M Takahashi; A Nakayama; M Pu; Y Dai; A Parashar; K Ohkus; Masashi Kato
Oncogene-linked in situ immunotherapy of pre-B lymphoma arising in E mu/ret transgenic mice.
British journal of cancer 1995;71(4):808-13.
1995: Masashi Kato; M Y Pu; Ken-Ichi Isobe; T Hattori; N Yanagita; I Nakashima
Cell type-oriented differential modulatory actions of saikosaponin-d on growth responses and DNA fragmentation of lymphocytes triggered by receptor-mediated and receptor-bypassed pathways.
Immunopharmacology 1995;29(3):207-13.
1995: M Pu; L Ma; K Ohkusu; Ken-Ichi Isobe; Ryo Taguchi; Hiroh Ikezawa; Michinari Hamaguchi; I Nakashima
Direct evidence of involvement of glycosylphosphatidylinositol-anchored proteins in the heavy metal-mediated signal delivery into T lymphocytes.
FEBS letters 1995;361(2-3):295-8.
1995: Yoshiaki Katano; M Y Pu; Anwarul A Akhand; Michinari Hamaguchi; Y Koga; Ken-Ichi Isobe; Y Fukuda; T Hayakawa; I Nakashima
Evidence of redox-linked signaling for producing a giant signal complex.
Journal of cellular biochemistry 1995;57(3):432-9.
1995: Shuji Hayashi; Ken-Ichi Isobe; Nobuhiko Emi; Hidechika Okada; M Yasutomi; Masataka Negita; C Koike; Kazuharu Uchida; Itsuo Yokoyama; H Takagi
Evidence that double transfection to xenoendothelial cells using GPI-anchoring complement regulatory factor (decay-accelerating factor and homologous restriction factor 20) gene is useful for the inhibition of human complement-mediated cytolysis.
Transplantation proceedings 1995;27(1):330.
1995: Z H Fan; Ken-Ichi Isobe; K Kiuchi; I Nakashima
Enhancement of nitric oxide production from activated macrophages by a purified form of ginsenoside (Rg1).
The American journal of Chinese medicine 1995;23(3-4):279-87.
1995: F Yoshida; Ken-Ichi Isobe; Seiichi Matsuo
In vivo effects of hyperglycemia on the outcome of acute mesangial injury in rats.
The Journal of laboratory and clinical medicine 1995;125(1):46-55.
1995: S M Rahman; M Y Pu; H Yi; K Ohkusu; Masashi Kato; Ken-Ichi Isobe; Ryo Taguchi; Hiroh Ikezawa; I Nakashima
Promotion of cytotoxic T-cell generation in mixed leukocyte culture by phosphatidylinositol-specific phospholipase C from Bacillus thuringiensis.
Infection and immunity 1995;63(1):259-63.
1994: Masashi Kato; M Y Pu; Ken-Ichi Isobe; T Iwamoto; F Nagase; T Lwin; Y H Zhang; T Hattori; N Yanagita; I Nakashima
Characterization of the immunoregulatory action of saikosaponin-d.
Cellular immunology 1994;159(1):15-25.
1994: Shuji Hayashi; C Koike; Ken-Ichi Isobe; Itsuo Yokoyama; H Takagi
[Organ xenotransplantation using human complement regulatory factor gene].
Nihon rinsho. Japanese journal of clinical medicine 1994;52(9):2492-503.
1994: K Ino; S Goto; Tomomitsu Okamoto; Seiji Nomura; Akihiro Nawa; Ken-Ichi Isobe; Shigehiko Mizutani; Y Tomoda
Expression of aminopeptidase N on human choriocarcinoma cells and cell growth suppression by the inhibition of aminopeptidase N activity.
Japanese journal of cancer research : Gann 1994;85(9):927-33.
1994: Ken-Ichi Isobe; Z H Fan; Nobuhiko Emi; I Nakashima
Gene transfer of TNF receptor for treatment of cancer by TNF.
Biochemical and biophysical research communications 1994;202(3):1538-42.
1994: K Aono; Ken-Ichi Isobe; I Nakashima; S Kondo; M Miyachi; Yuji Nimura
Kupffer cells cytotoxicity against hepatoma cells is related to nitric oxide.
Biochemical and biophysical research communications 1994;201(3):1175-81.
1994: Shuji Hayashi; Ken-Ichi Isobe; Nobuhiko Emi; Y Kasai; Itsuo Yokoyama; H Takagi
Protection from complement-mediated cytolysis in cross-species hepatocytes transfected with complement regulatory factor (HRF20) using retroviral vector.
Transplantation proceedings 1994;26(3):1252.
1994: Shuji Hayashi; Ken-Ichi Isobe; Nobuhiko Emi; Itsuo Yokoyama; H Takagi
Inhibition of species-specific complement-mediated cytolysis in xenoendothelial cells transfected with GPI-anchored complement regulatory factor (DAF, HRF20) gene using retroviral vector: comparison between single (DAF or HRF20) and double (DAF and HRF20) transfected xenoendothelial cells.
Transplantation proceedings 1994;26(3):1243-4.
1994: I Nakashima; M Y Pu; A Nishizaki; I Rosila; L Ma; Yoshiaki Katano; K Ohkusu; S M Rahman; Ken-Ichi Isobe; Michinari Hamaguchi
Redox mechanism as alternative to ligand binding for receptor activation delivering disregulated cellular signals.
Journal of immunology (Baltimore, Md. : 1950) 1994;152(3):1064-71.
1994: Yoshihisa Kodera; Ken-Ichi Isobe; M Yamauchi; K Kondoh; N Kimura; S Akiyama; K Itoh; I Nakashima; H Takagi
Expression of nm23 H-1 RNA levels in human gastric cancer tissues. A negative correlation with nodal metastasis.
Cancer 1994;73(2):259-65.
1994: M Parvin; Ken-Ichi Isobe; H Zohreh; S Goto; I Nakashima; Y Tomoda
Amniotic fluid enhances allogeneic cytotoxic T cell responses, whereas it suppresses mitogen-stimulated lymphocyte proliferation.
Microbiology and immunology 1994;38(4):327-30.
1994: Yoshihisa Kodera; S Akiyama; Ken-Ichi Isobe; K Kondo; K Ito; M Yamauchi; H Takagi
Expression of pi-glutathione S-transferase gene (GSTP1) in gastric cancer: lack of correlation with resistance against cis-diamminedichloroplatinum (II).
European journal of cancer (Oxford, England : 1990) 1994;30A(14):2158-62.
1993: S Kondo; N Ishiguro; H Iwata; I Nakashima; Ken-Ichi Isobe
The effects of nitric oxide on chondrocytes and lymphocytes.
Biochemical and biophysical research communications 1993;197(3):1431-7.
1993: Y Nishida; S Kondo; Y Miura; H Iwata; Ken-Ichi Isobe
Survival of syngeneic and allogeneic grafted bone in transgenic mice.
Biochemical and biophysical research communications 1993;196(3):1081-5.
1993: Ken-Ichi Isobe; I Nakashima
Nitric oxide production from a macrophage cell line: interaction with autologous and allogeneic lymphocytes.
Journal of cellular biochemistry 1993;53(3):198-205.
1993: T Satta; M Yamauchi; Ken-Ichi Isobe; Yoshihisa Kodera; A Ito; Seiji Akiyama; K Ito; H Takagi
Cisplatin enhances the metastatic potential of human colon carcinoma.
Gastroenterologia Japonica 1993;28(5):741.
1993: Takaaki Hasegawa; Ken-Ichi Isobe; I Nakashima; Kaoru Shimokata
Higher expression of topoisomerase II in lung cancers than normal lung tissues: different expression pattern from topoisomerase I.
Biochemical and biophysical research communications 1993;195(1):409-14.
1993: Y H Zhang; Ken-Ichi Isobe; F Nagase; T Lwin; Masashi Kato; Michinari Hamaguchi; Takashi Yokochi; I Nakashima
Glycyrrhizin as a promoter of the late signal transduction for interleukin-2 production by splenic lymphocytes.
Immunology 1993;79(4):528-34.
1993: T Satta; M Yamauchi; Ken-Ichi Isobe; Yoshihisa Kodera; A Ito; Seiji Akiyama; K Ito; H Takagi
Establishment of an in vivo cloning system for human gastric cancer.
Gastroenterologia Japonica 1993;28(4):580.
1993: S Kondo; Ken-Ichi Isobe; Naoki Ishiguro; I Nakashima; T Miura
Transforming growth factor-beta 1 enhances the generation of allospecific cytotoxic T lymphocytes.
Immunology 1993;79(3):459-64.
1993: Yoshihisa Kodera; Ken-Ichi Isobe; M Yamauchi; T Satta; T Hasegawa; S Oikawa; K Kondoh; Seiji Akiyama; K Itoh; I Nakashima
Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation.
British journal of cancer 1993;68(1):130-6.
1993: Ken-Ichi Isobe; I Nakashima
Abundant production of nitric oxide from murine macrophages by direct stimulation of tumor cells.
Biochemical and biophysical research communications 1993;192(2):499-504.
1993: S M Rahman; M Y Pu; Michinari Hamaguchi; T Iwamoto; Ken-Ichi Isobe; I Nakashima
Redox-linked ligand-independent cell surface triggering for extensive protein tyrosine phosphorylation.
FEBS letters 1993;317(1-2):35-8.
1993: T Hasegawa; Ken-Ichi Isobe; Y Tsuchiya; S Oikawa; H Nakazato; I Nakashima; K Shimokata
Nonspecific crossreacting antigen (NCA) is a major member of the carcinoembryonic antigen (CEA)-related gene family expressed in lung cancer.
British journal of cancer 1993;67(1):58-65.
1992: T Hasegawa; Ken-Ichi Isobe; I Nakashima; K Shimokata
Quantitative analysis of antigen for the induction of tolerance in carcinoembryonic antigen transgenic mice.
Immunology 1992;77(4):577-81.
1992: Ken-Ichi Isobe; I Nakashima
Feedback suppression of staphylococcal enterotoxin-stimulated T-lymphocyte proliferation by macrophages through inductive nitric oxide synthesis.
Infection and immunity 1992;60(11):4832-7.
1992: T Osuga; Tsuneo Morishima; N Hanada; K Nishikawa; Ken-Ichi Isobe; K Watanabe
Transfer of specific IgG and IgG subclasses to herpes simplex virus across the blood-brain barrier and placenta in preterm and term newborns.
Acta paediatrica (Oslo, Norway : 1992) 1992;81(10):792-6.
1992: I Nakashima; T Yoshida; Y H Zhang; M Y Pu; Ryo Taguchi; Hiroh Ikezawa; Ken-Ichi Isobe; T Iwamoto; Masashi Kato; T Lwin
T cell maturation stage-linked heterogeneity of the glycosylphosphatidylinositol membrane anchor of Thy-1.
Immunobiology 1992;185(5):466-74.
1992: J Lu; Y Sakai; W Wajjawalku; Ken-Ichi Isobe; M Saito; H Amo; A Kojima; K R Utsumi; M Takahashi; H Hiai
Establishment of transplantable tumor lines and in vitro cell lines of malignant thymoma developed in a BUF/Mna rat.
Japanese journal of cancer research : Gann 1992;83(6):618-24.
1992: S M Jamshedur Rahman; M V Pu; Y H Zhang; Michinari Hamaguchi; T Iwamoto; Ryo Taguchi; Hiroh Ikezawa; Ken-Ichi Isobe; T Yoshida; I Nakashima
Delivery of an accessory signal for cell activation by exogenous phosphatidylinositol-specific phospholipase C.
FEBS letters 1992;303(2-3):193-6.
1992: K Ino; Ken-Ichi Isobe; S Goto; I Nakashima; Y Tomoda
Inhibitory effect of bestatin on the growth of human lymphocytes.
Immunopharmacology 1992;23(3):163-71.
1992: T Kawabe; Ken-Ichi Isobe; Y Hasegawa; I Nakashima; K Shimokata
Immunosuppressive activity induced by nitric oxide in culture supernatant of activated rat alveolar macrophages.
Immunology 1992;76(1):72-8.
1992: Y H Zhang; Ken-Ichi Isobe; T Iwamoto; I Nakashima
Bidirectional control by glycyrrhizin of the growth response of lymphocytes stimulated through a receptor-bypassed pathway.
Immunology letters 1992;32(2):147-52.
1992: T Satta; Ken-Ichi Isobe; M Yamauchi; I Nakashima; H Takagi
Expression of MDR1 and glutathione S transferase-pi genes and chemosensitivities in human gastrointestinal cancer.
Cancer 1992;69(4):941-6.
1992: M Parvin; Ken-Ichi Isobe; S Goto; I Nakashima; Y Tomoda
Further evaluation of the pregnancy-linked down-regulation of the paternal antigen-specific splenic cytotoxic T lymphocyte activity in allogeneically pregnant mice.
Microbiology and immunology 1992;36(7):757-65.
1992: M Yamauchi; H Kumazawa; T Satta; I Sugawara; Ken-Ichi Isobe; Yoshihisa Kodera; K Ito; Toshiaki Watanabe; H Takagi
Prediction of doxorubicin resistance in gastrointestinal cancer by P-glycoprotein staining.
European journal of cancer (Oxford, England : 1990) 1992;28A(8-9):1422-7.
1991: T Iwamoto; M Takahashi; M Ito; K Hamatani; M Ohbayashi; W Wajjwalku; Ken-Ichi Isobe; I Nakashima
Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.
The EMBO journal 1991;10(11):3167-75.
1991: Y Hasegawa; Ken-Ichi Isobe; F Nagase; K Shimokata; I Nakashima
A possible site of in vivo action of cyclosporin A for transplantation immunity: comparative study with cyclophosphamide.
Immunobiology 1991;183(5):408-17.
1991: T Hasegawa; Ken-Ichi Isobe; Y Tsuchiya; S Oikawa; H Nakazato; H Ikezawa; I Nakashima; K Shimokata
Establishment and characterisation of human carcinoembryonic antigen transgenic mice.
British journal of cancer 1991;64(4):710-4.
1991: I Nakashima; Y H Zhang; S M Rahman; T Yoshida; Ken-Ichi Isobe; L N Ding; T Iwamoto; Michinari Hamaguchi; Hiroh Ikezawa; Ryo Taguchi
Evidence of synergy between Thy-1 and CD3/TCR complex in signal delivery to murine thymocytes for cell death.
Journal of immunology (Baltimore, Md. : 1950) 1991;147(4):1153-62.
1991: T Iwamoto; M Pu; M Ito; M Takahashi; Ken-Ichi Isobe; F Nagase; K Kawashima; Masatoshi Ichihara; I Nakashima
Preferential development of pre-B lymphomas with drastically down-regulated N-myc in the E mu-ret transgenic mice.
European journal of immunology 1991;21(8):1809-14.
1991: M Nakamura; T Yoshida; Ken-Ichi Isobe; T Iwamoto; S M Jamshedur Rahman; Y H Zhang; T Hasegawa; Masatoshi Ichihara; I Nakashima
Modulation of the secondary antibody response of murine lymphocytes to sheep red blood cells in vitro by neuraminidase and exoglycosidases.
Immunology letters 1991;29(3):235-40.
1991: L N Ding; T Yoshida; Ken-Ichi Isobe; S M Rahman; F Nagase; Takashi Yokochi; K Kawashima; I Nakashima
Characterization of the individual and cross-reactive antigens involved in the anti-tumor immunity induced by use of an H-2K-erbB recombinant gene transfectant.
Japanese journal of cancer research : Gann 1991;82(7):841-7.
1991: Ken-Ichi Isobe; I Nakashima
Homotypic aggregation of murine T lymphocytes induced by anti-Thy-1 monoclonal antibodies.
Immunology 1991;73(2):159-64.
1991: T Satta; Ken-Ichi Isobe; M Yamauchi; I Nakashima; Seiji Akiyama; K Itou; Toshiaki Watanabe; H Takagi
Establishment of drug resistance in human gastric and colon carcinoma xenograft lines.
Japanese journal of cancer research : Gann 1991;82(5):593-8.
1991: T Yoshida; Tomomitsu Hotta; Kaoru Shimokata; Masatoshi Ichihara; Ken-Ichi Isobe; I Nakashima
Augmented production of granulocyte-macrophage colony-stimulating factor and alpha/beta interferon in mice inoculated with heat-killed Corynebacterium liquefaciens.
Infection and immunity 1991;59(3):1032-6.
1991: L Ding; Ken-Ichi Isobe; T Yoshida; I Nakashima
Suppression of lymphocyte signal transduction by murine mastocytoma ascites.
Microbiology and immunology 1991;35(9):767-74.
1991: I Nakashima; Ken-Ichi Isobe; T Yoshida; T Iwamoto; F Nagase; Y H Zhang; M Pu; T Lwin
Allotype-linked immune response genes: roles in network control of the immune system.
Experimental and clinical immunogenetics 1991;8(3):121-39.
1990: Y H Zhang; T Yoshida; Ken-Ichi Isobe; S M Rahman; F Nagase; L Ding; I Nakashima
Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumour cell lines and normal cell populations.
Immunology 1990;70(3):405-10.
1990: Kiyotaka Kuzushima; Ken-Ichi Isobe; Tsuneo Morishima; A Takatsuki; I Nakashima
Inhibitory effect of herpes simplex virus infection to target cells on recognition of minor histocompatibility antigens by cytotoxic T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(12):4536-40.
1990: T Iwamoto; M Takahashi; M Ito; Michinari Hamaguchi; Ken-Ichi Isobe; N Misawa; J Asai; T Yoshida; I Nakashima
Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.
Oncogene 1990;5(4):535-42.
1990: Toshio Miyata; Ken-Ichi Isobe; R Dawson; M A Ritter; Reiko Inagi; O Oda; Ryo Taguchi; Hiroh Ikezawa; I Inoue; H Seo
Determination of the molecular nature and cellular localization of Thy-1 in human renal tissue.
Immunology 1990;69(3):391-5.
1990: L N Ding; Ken-Ichi Isobe; T Yoshida; K Kawashima; I Nakashima
Induction of high-grade anti-tumor immunity by use of a recombinant H-2Kb/avian erythroblastosis virus erbB gene transfectant.
Cancer immunology, immunotherapy : CII 1990;31(2):115-20.
1990: L Ding; Ken-Ichi Isobe; T Iwamoto; T Yoshida; F Nagase; K Kawashima; I Nakashima
Cytotoxic T lymphocyte recognition of the H-2-erbB hybrid gene product lacking the complete H-2 domain structure.
International immunology 1990;2(1):91-7.
1989: Ken-Ichi Isobe; Y Hasegawa; T Iwamoto; Takaaki Hasegawa; K Kawashima; L N Ding; I Nakashima
Induction of antitumor immunity in mice by allo-major histocompatibility complex class I gene transfectant with strong antigen expression.
Journal of the National Cancer Institute 1989;81(23):1823-8.
1989: Toshio Miyata; Ken-Ichi Isobe; Reiko Inagi; Ryo Taguchi; Hiroh Ikezawa; Ichiro Takai; Y Fujita; T Iwamoto; T Hasegawa; O Oda
Rat mesangial cells actively produce phosphatidylinositol-anchored Thy-1.
Immunology 1989;67(4):531-3.
1989: H Lai; Y Hasegawa; K Mizoguchi; T Yoshida; Ken-Ichi Isobe; K Shimokata; K Kawashima; I Nakashima
Mode of alloantibody-mediated blockade of allo-sensitization for tumor allograft rejection.
Immunobiology 1989;179(1):33-43.
1989: Reiko Inagi; T Yoshida; Ken-Ichi Isobe; I Nakashima
Donor Igh-linked genetic control of allotype-specific antibody response.
Immunogenetics 1989;30(2):70-5.
1989: Ken-Ichi Isobe; T Yoshida; T Iwamoto; I Nakashima
Carbohydrates mediate tissue type-specific membrane activity for Thy-1 alloantibody response.
International immunology 1989;1(1):90-3.
1988: K Mizoguchi; Ken-Ichi Isobe; T Yoshida; T Iwamoto; T Hasegawa; L Ding; S M Rahman; Toshio Miyata; F Nagase; K Shimokata
Further evidence for H-2-unrestricted induction of minor histocompatibility antigens-specific T cell immunity in vivo.
Immunology letters 1988;19(1):41-7.
1988: T Yoshida; I Nakashima; Takashi Yokochi; K Mizoguchi; R N Ding; N Kato; Ken-Ichi Isobe; F Nagase; K Ando; T Iwamoto
Augmentation by Corynebacterium liquefaciens of erythrocyte surface H-2 expression and alloimmunogenicity for antibody responses.
Transplantation 1988;46(2):261-6.
1988: K I Ando; Ken-Ichi Isobe; T Hasegawa; T Iwamoto; R N Ding; J Rahman; Yoshinao Muro; T Yoshida; F Nagase; K Kawashima
Genetic and stimulator cell requirements for generation and activation of minor histocompatibility antigen-specific memory cytotoxic T-lymphocyte precursors.
Immunology 1988;64(4):661-7.
1988: Y Hasegawa; I Nakashima; K Ando; K Mizoguchi; F Nagase; Ken-Ichi Isobe; K Kawashima; K Shimokata; T Yoshida; T Iwamoto
Dynamics of cytotoxic T lymphocyte precursors in vivo assessed by change in the radiation sensitivity. Evidence for development of radiation-sensitive memory cells without clonal expansion.
Scandinavian journal of immunology 1988;28(1):43-53.
1988: Y Hasegawa; I Nakashima; K Mizoguchi; F Nagase; Ken-Ichi Isobe; K Shimokata; K Kawashima; K Ando; T Yoshida; T Iwamoto
Biphasic radiation-sensitivity of the transplantation immunity for rejection of an allogeneic ascites tumor.
Immunobiology 1988;177(2):120-33.
1988: K Ando; I Nakashima; F Nagase; Ken-Ichi Isobe; K Kawashima; Y Hasegawa; T Yoshida; T Iwamoto; T Hasegawa; Yoshinao Muro
Induction and characterization of minor histocompatibility antigens. Specific primary cytotoxic T lymphocyte responses in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1988;140(3):723-9.
1987: F Nagase; S M Rahman; Takashi Yokochi; K Kawashima; Ken-Ichi Isobe; T Yoshida; E Nagura; I Nakashima
Dynamics of generation of antigen loss variants from L1210 murine leukemia clones detected by a tumor-specific T-cell clone.
Cancer research 1987;47(24 Pt 1):6494-9.
1987: F Nagase; K Ueda; K Kawashima; S M Jamshedur Rahman; Ken-Ichi Isobe; T Yoshida; Y Hasegawa; K Ando; T Iwamoto; E Nagura
Development of host-dependent high-grade tumor-specific immunity through a novel mechanism triggered by the Lyt-2+ tumor-specific T cell clone (K7L) that induces temporal growth of L1210 leukemia-K7L-variant.
Journal of immunology (Baltimore, Md. : 1950) 1987;138(7):2359-65.
1987: Takashi Yokochi; K Kawashima; I Nakashima; F Nagase; Ken-Ichi Isobe; E Nagura; K Yamada; T Miyadai; Y Kimura
Identification and characterization of a unique tumor-associated surface antigen on L1210 leukemia cells recognized by semisyngeneic antisera.
Cancer research 1987;47(4):1006-9.
1986: F Nagase; K Ueda; I Nakashima; K Kawashima; Ken-Ichi Isobe; E Nagura; K Yamada; Takashi Yokochi; Y Hasegawa; T Yoshida
Establishment of a murine leukemia L1210-specific T-cell clone displaying novel in vivo anti-tumor activity.
International journal of cancer. Journal international du cancer 1986;38(6):907-14.
1985: K Kawashima; Ken-Ichi Isobe; F Nagase; Takashi Yokochi; E Nagura; Y Hasegawa; H Morishita; K Yamada; I Nakashima
Simultaneous development of humoral and cellular tumor-specific immunity against L1210 mouse leukemia.
Leukemia research 1985;9(7):935-9.