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Lori Isom

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William J Brackenbury; Heather A O'Malley; Jack M Parent; Yukun Yuan; Lori L Isom
Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.
Chunling Chen; Tigwa H Davis; Jeffrey D Calhoun; Luis Felix Lopez-Santiago; James L Salzer; Yanqing Zhang; Ningna Zhou; Lori L Isom
Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits.
Mischa Uebachs; Christian Wolff; Christina Albus; Lori L Isom; Isabelle Niespodziany; Thoralf Opitz; Heinz Beck
Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents.

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All Publications

2013: William J Brackenbury; Heather A O'Malley; Jack M Parent; Yukun Yuan; Lori L Isom
Abnormal neuronal patterning occurs during early postnatal brain development of Scn1b-null mice and precedes hyperexcitability.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(3):1089-94.
2012: Chunling Chen; Tigwa H Davis; Jeffrey D Calhoun; Luis Felix Lopez-Santiago; James L Salzer; Yanqing Zhang; Ningna Zhou; Lori L Isom
Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits.
The Journal of biological chemistry 2012;287(46):39061-9.
2012: Mischa Uebachs; Christian Wolff; Christina Albus; Lori L Isom; Isabelle Niespodziany; Thoralf Opitz; Heinz Beck
Loss of β1 accessory Na+ channel subunits causes failure of carbamazepine, but not of lacosamide, in blocking high-frequency firing via differential effects on persistent Na+ currents.
Epilepsia 2012;53(11):1959-67.
2012: Ming Yang; Jeffrey D Calhoun; Lori L Isom; David J Kozminski; Rohan Modak; Lindsey A Wold; William J Brackenbury
Therapeutic potential for phenytoin: targeting Na(v)1.5 sodium channels to reduce migration and invasion in metastatic breast cancer.
Breast cancer research and treatment 2012;134(2):603-15.
2012: Céline Marionneau; Yarimar Carrasquillo; Lori L Isom; Andrew J Link; Aaron J Norris; R Reid Townsend; Jeanne M Nerbonne
The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(17):5716-27.
2011: Xianming Lin; Nian Liu; Jia Lu; Jie Zhang; Justus Mukolu Anumonwo; Glenn I Fishman; Lori L Isom; Mario Delmar
Subcellular heterogeneity of sodium current properties in adult cardiac ventricular myocytes.
Heart rhythm : the official journal of the Heart Rhythm Society 2011;8(12):1923-30.
2011: Gustavo A Patino; Guy A Rouleau; Ron G Lafrenière; Luis Felix Lopez-Santiago; Heather A O'Malley; Yangyang Bao; William J Brackenbury; Jeffrey D Calhoun; Chunling Chen; Patrick Cossette; Lori L Isom
Voltage-gated Na+ channel β1B: a secreted cell adhesion molecule involved in human epilepsy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(41):14577-91.
2011: Priscila Y Sato; Steven Taffet; Wanda Coombs; Kathleen J Green; Lori L Isom; Xianming Lin; Oxana Nekrasova; Mario Delmar
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc.
Circulation research 2011;109(2):193-201.
2011: Luis Felix Lopez-Santiago; William J Brackenbury; Chunling Chen; Lori L Isom
Na+ channel Scn1b gene regulates dorsal root ganglion nociceptor excitability in vivo.
The Journal of biological chemistry 2011;286(26):22913-23.
2011: William J Brackenbury; Lori L Isom
Na Channel β Subunits: Overachievers of the Ion Channel Family.
Frontiers in pharmacology 2011;2():53.
2010: Gustavo A Patino; Lori L Isom
Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease.
Neuroscience letters 2010;486(2):53-9.
2010: Heather A O'Malley; Yanghae Park; Lori L Isom; Margaret E Gnegy
PKCbeta co-localizes with the dopamine transporter in mesencephalic neurons.
Neuroscience letters 2010;480(1):40-3.
2010: Mischa Uebachs; Thoralf Opitz; Michel Royeck; Gesa Dickhof; Marie-Therese Horstmann; Lori L Isom; Heinz Beck
Efficacy loss of the anticonvulsant carbamazepine in mice lacking sodium channel beta subunits via paradoxical effects on persistent sodium currents.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(25):8489-501.
2010: William J Brackenbury; Jeffrey D Calhoun; Chunling Chen; Haruko Miyazaki; Nobuyuki Nukina; Fumitaka Oyama; Barbara Ranscht; Lori L Isom
Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(5):2283-8.
2010: Yunhong Bai; Xuebao Zhang; Istvan Katona; Mario Andre Saporta; chris hall; Heather A O'Malley; Lori L Isom; Ueli Suter; Jun Li
Conduction block in PMP22 deficiency.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30(2):600-8.
2010: Sarah B Geisler; Kathleen J Green; Lori L Isom; Sasha Meshinchi; Jeffrey R Martens; Mario Delmar; Mark W Russell
Ordered assembly of the adhesive and electrochemical connections within newly formed intercalated disks in primary cultures of adult rat cardiomyocytes.
Journal of biomedicine & biotechnology 2010;2010():624719.
2009: Dyke P McEwen; Chunling Chen; Laurence S Meadows; Luis Felix Lopez-Santiago; Lori L Isom
The voltage-gated Na+ channel beta3 subunit does not mediate trans homophilic cell adhesion or associate with the cell adhesion molecule contactin.
Neuroscience letters 2009;462(3):272-5.
2009: Priscila Y Sato; Hassan Musa; Wanda Coombs; Guadalupe Guerrero-Serna; Gustavo A Patiño; Steven M Taffet; Lori L Isom; Mario Delmar
Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes.
Circulation research 2009;105(6):523-6.
2009: Gustavo A Patino; Lieve R F Claes; Luis Felix Lopez-Santiago; Emily Slat; Raja S R Dondeti; Chunling Chen; Heather A O'Malley; Charles B B Gray; Haruko Miyazaki; Nobuyuki Nukina; Fumitaka Oyama; Peter De Jonghe; Lori L Isom
A functional null mutation of SCN1B in a patient with Dravet syndrome.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(34):10764-78.
2009: Athina-Myrto CHIONI; William J Brackenbury; Jeffrey D Calhoun; Lori L Isom; Mustafa B A Djamgoz
A novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.
The international journal of biochemistry & cell biology 2009;41(5):1216-27.
2009: Teresa K Aman; Tina M Grieco-Calub; Chunling Chen; Raffaella Rusconi; Emily Slat; Lori L Isom; Indira M Raman
Regulation of persistent Na current by interactions between beta subunits of voltage-gated Na channels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2009;29(7):2027-42.
2009: Heather A O'Malley; Andrew B Shreiner; Gwo-Hsiao Chen; Gary B Huffnagle; Lori L Isom
Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.
Molecular and cellular neurosciences 2009;40(2):143-55.
2008: William J Brackenbury; Mustafa B A Djamgoz; Lori L Isom
An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2008;14(6):571-83.
2008: Amanda J Fein; Melissa A Wright; Emily Slat; Angeles B Ribera; Lori L Isom
scn1bb, a zebrafish ortholog of SCN1B expressed in excitable and nonexcitable cells, affects motor neuron axon morphology and touch sensitivity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(47):12510-22.
2008: William J Brackenbury; Lori L Isom
Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets.
Expert opinion on therapeutic targets 2008;12(9):1191-203.
2008: William J Brackenbury; Tigwa H Davis; Chunling Chen; Emily Slat; Matthew J Detrow; Travis Dickendesher; Barbara Ranscht; Lori L Isom
Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008;28(12):3246-56.
2007: Luis Felix Lopez-Santiago; Laurence S Meadows; Sara J Ernst; Chunling Chen; Jyoti D Malhotra; Dyke P McEwen; Audrey Speelman; Jeffrey L Noebels; Sebastian K G Maier; Anatoli N Lopatin; Lori L Isom
Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals.
Journal of molecular and cellular cardiology 2007;43(5):636-47.
2007: Chunling Chen; Travis Dickendesher; Fumitaka Oyama; Haruko Miyazaki; Nobuyuki Nukina; Lori L Isom
Floxed allele for conditional inactivation of the voltage-gated sodium channel beta1 subunit Scn1b.
Genesis (New York, N.Y. : 2000) 2007;45(9):547-53.
2007: Amanda J Fein; Laurence S Meadows; Chunling Chen; Emily Slat; Lori L Isom
Cloning and expression of a zebrafish SCN1B ortholog and identification of a species-specific splice variant.
BMC genomics 2007;8():226.
2006: Luis Felix Lopez-Santiago; Marie Pertin; Xavier Morisod; Chunling Chen; Shuangsong Hong; John W Wiley; Isabelle Decosterd; Lori L Isom
Sodium channel beta2 subunits regulate tetrodotoxin-sensitive sodium channels in small dorsal root ganglion neurons and modulate the response to pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(30):7984-94.
2005: Marie Pertin; Ru-Rong Ji; Temugin Berta; Andrew J Powell; Laurie A Karchewski; Simon N Tate; Lori L Isom; Clifford J Woolf; Nicolas Gilliard; Donat R Spahn; Isabelle Decosterd
Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(47):10970-80.
2005: Laurence S Meadows; Lori L Isom
Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes.
Cardiovascular research 2005;67(3):448-58.
2005: Tina M Grieco; Jyoti D Malhotra; Chunling Chen; Lori L Isom; Indira M Raman
Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current.
Neuron 2005;45(2):233-44.
2004: Dyke P McEwen; Lori L Isom
Heterophilic interactions of sodium channel beta1 subunits with axonal and glial cell adhesion molecules.
The Journal of biological chemistry 2004;279(50):52744-52.
2004: Tigwa H Davis; Chunling Chen; Lori L Isom
Sodium channel beta1 subunits promote neurite outgrowth in cerebellar granule neurons.
The Journal of biological chemistry 2004;279(49):51424-32.
2004: Jay Spampanato; Jennifer A Kearney; G de Haan; Dyke P McEwen; Andrew Escayg; Ildiko Aradi; Bryan T MacDonald; Stephen I Levin; Ivan Soltesz; Paolo Benna; Elisa Montalenti; Lori L Isom; Alan L Goldin; Miriam H Meisler
A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(44):10022-34.
2004: Jyoti D Malhotra; Veena Thyagarajan; Chunling Chen; Lori L Isom
Tyrosine-phosphorylated and nonphosphorylated sodium channel beta1 subunits are differentially localized in cardiac myocytes.
The Journal of biological chemistry 2004;279(39):40748-54.
2004: Shuangsong Hong; Thomas J Morrow; Pamela E Paulson; Lori L Isom; John W Wiley
Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat.
The Journal of biological chemistry 2004;279(28):29341-50.
2004: Chunling Chen; Ruth E Westenbroek; Xiaorong Xu; Chris A Edwards; Dorothy R Sorenson; Yuan Chen; Dyke P McEwen; Heather A O'Malley; Vandana Bharucha; Laurence S Meadows; Gabriel A Knudsen; Alex Vilaythong; Jeffrey L Noebels; Thomas L Saunders; Todd Scheuer; Peter Shrager; William A Catterall; Lori L Isom
Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004;24(16):4030-42.
2004: Dyke P McEwen; Laurence S Meadows; Chunling Chen; Veena Thyagarajan; Lori L Isom
Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin.
The Journal of biological chemistry 2004;279(16):16044-9.
2003: Eleonora Aronica; Dirk Troost; Annemieke J M Rozemuller; Bulent Yankaya; Gerard H Jansen; Lori L Isom; Jan A Gorter
Expression and regulation of voltage-gated sodium channel beta1 subunit protein in human gliosis-associated pathologies.
Acta neuropathologica 2003;105(5):515-23.
2002: Chunling Chen; Vandana Bharucha; Yuan Chen; Ruth E Westenbroek; Angus Brown; Jyoti D Malhotra; Dorothy Jones; Christy Avery; Patrick J Gillespie; Kristin A Kazen-Gillespie; Katie Kazarinova-Noyes; Peter Shrager; Thomas L Saunders; Robert L Macdonald; Bruce R Ransom; Todd Scheuer; William A Catterall; Lori L Isom
Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):17072-7.
2002: Laurence S Meadows; Jyoti D Malhotra; Andrew Loukas; Veena Thyagarajan; Kristin A Kazen-Gillespie; Matthew C Koopman; Steven Kriegler; Lori L Isom; David S Ragsdale
Functional and biochemical analysis of a sodium channel beta1 subunit mutation responsible for generalized epilepsy with febrile seizures plus type 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2002;22(24):10699-709.
2002: Jyoti D Malhotra; Matthew C Koopmann; Kristin A Kazen-Gillespie; Nicholas Fettman; Michael Hortsch; Lori L Isom
Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin.
The Journal of biological chemistry 2002;277(29):26681-8.
2002: Jan A Gorter; Erwin A Van Vliet; Fernando Lopes da Silva; Lori L Isom; Eleonora Aronica
Sodium channel beta1-subunit expression is increased in reactive astrocytes in a rat model for mesial temporal lobe epilepsy.
The European journal of neuroscience 2002;16(2):360-4.
2002: Lori L Isom
The role of sodium channels in cell adhesion.
Frontiers in bioscience : a journal and virtual library 2002;7():12-23.
2002: Lori L Isom
Beta subunits: players in neuronal hyperexcitability?
Novartis Foundation symposium 2002;241():124-38; discussion 138-43, 226-32.
2001: Katie Kazarinova-Noyes; Jyoti D Malhotra; Dyke P McEwen; LN Mattei; Erik O Berglund; Barbara Ranscht; S Rock Levinson; M Schachner; Peter Shrager; Lori L Isom; Zhi-Cheng Xiao
Contactin associates with Na+ channels and increases their functional expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2001;21(19):7517-25.
2001: M R Kaplan; M H Cho; Erik M Ullian; Lori L Isom; S Rock Levinson; Ben A Barres
Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier.
Neuron 2001;30(1):105-19.
2001: J Dhar Malhotra; C Chen; Ilaria Rivolta; Hugues Abriel; R Malhotra; LN Mattei; Frank C Brosius III; Robert Kass; Lori L Isom
Characterization of sodium channel alpha- and beta-subunits in rat and mouse cardiac myocytes.
Circulation 2001;103(9):1303-10.
2001: Laurence S Meadows; Jyoti D Malhotra; A Stetzer; Lori L Isom; David S Ragsdale
The intracellular segment of the sodium channel beta 1 subunit is required for its efficient association with the channel alpha subunit.
Journal of neurochemistry 2001;76(6):1871-8.
2001: Lori L Isom
Sodium channel beta subunits: anything but auxiliary.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2001;7(1):42-54.
2000: Jyoti D Malhotra; Kristin A Kazen-Gillespie; Michael Hortsch; Lori L Isom
Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact.
The Journal of biological chemistry 2000;275(15):11383-8.
2000: Lori L Isom
I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain? I. Cellular and molecular biology of sodium channel beta-subunits: therapeutic implications for pain?
American journal of physiology. Gastrointestinal and liver physiology 2000;278(3):G349-53.
2000: Kristin A Kazen-Gillespie; David S Ragsdale; M R D'Andrea; LN Mattei; K E Rogers; Lori L Isom
Cloning, localization, and functional expression of sodium channel beta1A subunits.
The Journal of biological chemistry 2000;275(2):1079-88.
1999: Zhi-Cheng Xiao; David S Ragsdale; Jyoti D Malhotra; LN Mattei; Peter E Braun; M Schachner; Lori L Isom
Tenascin-R is a functional modulator of sodium channel beta subunits.
The Journal of biological chemistry 1999;274(37):26511-7.
1998: KA McCormick; Lori L Isom; David S Ragsdale; D Smith; Todd Scheuer; William A Catterall
Molecular determinants of Na+ channel function in the extracellular domain of the beta1 subunit.
The Journal of biological chemistry 1998;273(7):3954-62.
1996: Lori L Isom; W A Catterall
Na+ channel subunits and Ig domains.
Nature 1996;383(6598):307-8.
1996: Julie M Jones; Miriam H Meisler; Lori L Isom
Scn2b, a voltage-gated sodium channel beta2 gene on mouse chromosome 9.
Genomics 1996;34(2):258-9.
1995: Lori L Isom; David S Ragsdale; K S De Jongh; Ruth E Westenbroek; B F Reber; Todd Scheuer; William A Catterall
Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif.
Cell 1995;83(3):433-42.
1995: Yusheng Qu; Lori L Isom; Ruth E Westenbroek; J C Rogers; T N Tanada; K A McCormick; Todd Scheuer; William A Catterall
Modulation of cardiac Na+ channel expression in Xenopus oocytes by beta 1 subunits.
The Journal of biological chemistry 1995;270(43):25696-701.
1995: Lori L Isom; Todd Scheuer; A B Brownstein; David S Ragsdale; Brian J Murphy; William A Catterall
Functional co-expression of the beta 1 and type IIA alpha subunits of sodium channels in a mammalian cell line.
The Journal of biological chemistry 1995;270(7):3306-12.
1994: D E Patton; Lori L Isom; William A Catterall; Alan L Goldin
The adult rat brain beta 1 subunit modifies activation and inactivation gating of multiple sodium channel alpha subunits.
The Journal of biological chemistry 1994;269(26):17649-55.
1994: Lori L Isom; K S De Jongh; William A Catterall
Auxiliary subunits of voltage-gated ion channels.
Neuron 1994;12(6):1183-94.
1992: Lori L Isom; K S De Jongh; D E Patton; B F Reber; J Offord; H Charbonneau; K Walsh; Alan L Goldin; William A Catterall
Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel.
Science (New York, N.Y.) 1992;256(5058):839-42.
1987: Lori L Isom; E J Cragoe; Lee E Limbird
Multiple receptors linked to inhibition of adenylate cyclase accelerate Na+/H+ exchange in neuroblastoma x glioma cells via a mechanism other than decreased cAMP accumulation.
The Journal of biological chemistry 1987;262(36):17504-9.
1987: Lori L Isom; E J Cragoe; L E Limbird
Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells.
The Journal of biological chemistry 1987;262(14):6750-7.