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Motohide Isono

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Sheldon Chen; M Carmen Iglesias-de la Cruz; Bun Jim; Soon Won Hong; Motohide Isono; Fuad N Ziyadeh
Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice.
Motohide Isono; Sheldon Chen; Soon Won Hong; M Carmen Iglesias-de la Cruz; Fuad N Ziyadeh
Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells.
M Carmen Iglesias-de la Cruz; Fuad N Ziyadeh; Motohide Isono; Martine Kouahou; Dong Cheol Han; Raghu Kalluri; Peter Mundel; Sheldon Chen
Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes.

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All Publications

2003: Sheldon Chen; M Carmen Iglesias-de la Cruz; Bun Jim; Soon Won Hong; Motohide Isono; Fuad N Ziyadeh
Reversibility of established diabetic glomerulopathy by anti-TGF-beta antibodies in db/db mice.
Biochemical and biophysical research communications 2003;300(1):16-22.
2002: Motohide Isono; Sheldon Chen; Soon Won Hong; M Carmen Iglesias-de la Cruz; Fuad N Ziyadeh
Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-beta-induced fibronectin in mesangial cells.
Biochemical and biophysical research communications 2002;296(5):1356-65.
2002: M Carmen Iglesias-de la Cruz; Fuad N Ziyadeh; Motohide Isono; Martine Kouahou; Dong Cheol Han; Raghu Kalluri; Peter Mundel; Sheldon Chen
Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes.
Kidney international 2002;62(3):901-13.
2001: Sixue Chen; Soon Won Hong; M Carmen Iglesias-de la Cruz; Motohide Isono; A Casaretto; Fuad N Ziyadeh
The key role of the transforming growth factor-beta system in the pathogenesis of diabetic nephropathy.
Renal failure 2001;23(3-4):471-81.
2001: Soon Won Hong; Motohide Isono; Sixue Chen; M Carmen Iglesias-de la Cruz; Dong Cheol Han; Fuad N Ziyadeh
Increased glomerular and tubular expression of transforming growth factor-beta1, its type II receptor, and activation of the Smad signaling pathway in the db/db mouse.
The American journal of pathology 2001;158(5):1653-63.
2001: Dong Cheol Han; Motohide Isono; Sixue Chen; A Casaretto; Soon Won Hong; Gunter Wolf; Fuad N Ziyadeh
Leptin stimulates type I collagen production in db/db mesangial cells: glucose uptake and TGF-beta type II receptor expression.
Kidney international 2001;59(4):1315-23.
2000: Motohide Isono; M C Cruz; Sixue Chen; Soon Won Hong; Fuad N Ziyadeh
Extracellular signal-regulated kinase mediates stimulation of TGF-beta1 and matrix by high glucose in mesangial cells.
Journal of the American Society of Nephrology : JASN 2000;11(12):2222-30.
2000: Fuad N Ziyadeh; Brenda B Hoffman; Dong Cheol Han; M Carmen Iglesias-de la Cruz; Soon Won Hong; Motohide Isono; Sixue Chen; Tracy A McGowan; Kumar Sharma
Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(14):8015-20.
2000: Motohide Isono; András Mogyorósi; Dong Cheol Han; Brenda B Hoffman; Fuad N Ziyadeh
Stimulation of TGF-beta type II receptor by high glucose in mouse mesangial cells and in diabetic kidney.
American journal of physiology. Renal physiology 2000;278(5):F830-8.
1999: Dong Cheol Han; Motohide Isono; Brenda B Hoffman; Fuad N Ziyadeh
High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-beta.
Journal of the American Society of Nephrology : JASN 1999;10(9):1891-9.