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Ayako Isotani

Research Profile

Living Beings

Anatomy

Disorders

Male Infertility

Physiology

Cell Differentiation

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Publications

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Yoshitaka Fujihara; Masahito Ikawa; Naokazu Inoue; Ayako Isotani; Yuhkoh Satouh; Masaru Okabe
SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
Kyoji Horie; Yue Huang; Ryuji Ikeda; Ayako Isotani; Chikara Kokubu; Akiko Oshitani; Keiko Akagi; Allan Bradley; Junko Yoshida; Kosuke Yusa; Junji Takeda
A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
Ayako Isotani; Hide Hatayama; Kazuhiro Kaseda; Masahito Ikawa; Masaru Okabe
Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.

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All Publications

2012: Yoshitaka Fujihara; Masahito Ikawa; Naokazu Inoue; Ayako Isotani; Yuhkoh Satouh; Masaru Okabe
SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia.
Development (Cambridge, England) 2012;139(19):3583-9.
2011: Kyoji Horie; Yue Huang; Ryuji Ikeda; Ayako Isotani; Chikara Kokubu; Akiko Oshitani; Keiko Akagi; Allan Bradley; Junko Yoshida; Kosuke Yusa; Junji Takeda
A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.
Nature methods 2011;8(12):1071-7.
2011: Ayako Isotani; Hide Hatayama; Kazuhiro Kaseda; Masahito Ikawa; Masaru Okabe
Formation of a thymus from rat ES cells in xenogeneic nude mouse↔rat ES chimeras.
Genes to cells : devoted to molecular & cellular mechanisms 2011;16(4):397-405.
2009: Yuka Morioka; Ayako Isotani; Robert Glen Oshima; Masaru Okabe; Masahito Ikawa
Placenta-specific gene activation and inactivation using integrase-defective lentiviral vectors with the Cre/LoxP system.
Genesis (New York, N.Y. : 2000) 2009;47(12):793-8.
2009: Keizo Tokuhiro; Ayako Isotani; Sadaki Yokota; Yoshihisa Yano; Shigeru Oshio; Mika Hirose; Morimasa Wada; Kyoko Fujita; Yukiko Ogawa; Masaru Okabe; Yoshitake Nishimune; Hiromitsu Tanaka
OAZ-t/OAZ3 is essential for rigid connection of sperm tails to heads in mouse.
PLoS genetics 2009;5(11):e1000712.
2009: Chikara Kokubu; Kyoji Horie; Koichiro Abe; Ryuji Ikeda; Sumi Mizuno; Yoshihiro Uno; Sanae Ogiwara; Masato Ohtsuka; Ayako Isotani; Masaru Okabe; Kenji Imai; Junji Takeda
A transposon-based chromosomal engineering method to survey a large cis-regulatory landscape in mice.
Nature genetics 2009;41(8):946-52.
2009: Ryo Yamaguchi; Yuko Muro; Ayako Isotani; Keizo Tokuhiro; Kazuhiro Takumi; Ibrahim Adham; Masahito Ikawa; Masaru Okabe
Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse.
Biology of reproduction 2009;81(1):142-6.
2008: Keizo Tokuhiro; Mika Hirose; Yasushi Miyagawa; Akira Tsujimura; Shinji Irie; Ayako Isotani; Masaru Okabe; Yoshiro Toyama; Chizuru Ito; Kiyotaka Toshimori; Ken Takeda; Shigeru Oshio; Hitoshi Tainaka; Junji Tsuchida; Akihiko Okuyama; Yoshitake Nishimune; Hiromitsu Tanaka
Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis.
The Journal of biological chemistry 2008;283(27):19039-48.
2007: Yuka Okada; Yuko Ueshin; Ayako Isotani; Tomoko Saito-Fujita; Hisako Nakashima; Kazushi Kimura; Akira Mizoguchi; Masatsugu Oh-hora; Yoshiko Mori; Masato Ogata; Robert Glen Oshima; Masaru Okabe; Masahito Ikawa
Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer.
Nature biotechnology 2007;25(2):233-7.
2006: Shin Kobayashi; Ayako Isotani; Nathan Mise; Masamichi Yamamoto; Yoshitaka Fujihara; Kazuhiro Kaseda; Tomoko Nakanishi; Masahito Ikawa; Hiroshi Hamada; Kuniya Abe; Masaru Okabe
Comparison of gene expression in male and female mouse blastocysts revealed imprinting of the X-linked gene, Rhox5/Pem, at preimplantation stages.
Current biology : CB 2006;16(2):166-72.
2005: Hiromitsu Tanaka; Naoko Iguchi; Ayako Isotani; Kouichi Kitamura; Yoshiro Toyama; Yasuhiro Matsuoka; Masayoshi Onishi; Kumiko Masai; Mamiko Maekawa; Kiyotaka Toshimori; Masaru Okabe; Yoshitake Nishimune
HANP1/H1T2, a novel histone H1-like protein involved in nuclear formation and sperm fertility.
Molecular and cellular biology 2005;25(16):7107-19.
2005: Ayako Isotani; Tomoko Nakanishi; Shin Kobayashi; Jiyoung Lee; Shinichiro Chuma; Norio Nakatsuji; Fumitoshi Ishino; Masaru Okabe
Genomic imprinting of XX spermatogonia and XX oocytes recovered from XX<-->XY chimeric testes.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(11):4039-44.
2005: Naokazu Inoue; Masahito Ikawa; Ayako Isotani; Masaru Okabe
The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs.
Nature 2005;434(7030):234-8.
2004: Tomoko Nakanishi; Ayako Isotani; Ryo Yamaguchi; Masahito Ikawa; Tadashi Baba; Susan S Suarez; Masaru Okabe
Selective passage through the uterotubal junction of sperm from a mixed population produced by chimeras of calmegin-knockout and wild-type male mice.
Biology of reproduction 2004;71(3):959-65.
2002: Tomoko Nakanishi; Asato Kuroiwa; Shuichi Yamada; Ayako Isotani; Atsuko Yamashita; Ai Tairaka; Tamon Hayashi; Tatsuya Takagi; Masahito Ikawa; Yoichi Matsuda; Masaru Okabe
FISH analysis of 142 EGFP transgene integration sites into the mouse genome.
Genomics 2002;80(6):564-74.