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Alain Israël
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19
Courtois, Gilles
14
Kourilsky, Philippe
12
Weil, Robert
11
Logeat, Frédérique
10
Mémet, Sylvie
10
Brou, Christel
8
Whiteside, ST
7
Bessia, Christine
6
Agou, Fabrice
5
Lilienbaum, Alain
5
Smahi, Asma
5
Véron, Michel
5
Yamaoka, Shoji
4
Goudeau, Bertrand
4
Six, Emmanuelle
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All Publications
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2009: Laplantine E; Fontan E; Chiaravalli J; Lopez T; Lakisic G; Véron M; Agou F; Israël Alain
NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain.
The EMBO journal 2009;28(19):2885-95.
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2009: Journo Chloé; Filipe Josina; About Frédégonde; Chevalier Sébastien A; Afonso Philippe V; Brady John N; Flynn David; Tangy Frédéric; Israël Alain; Vidalain Pierre-Olivier; Mahieux Renaud; Weil Robert
NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein.
PLoS pathogens 2009;5(7):e1000521.
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2008: Heuss Sara Farrah; Ndiaye-Lobry Delphine; Six Emmanuelle M; Israël Alain; Logeat Frédérique
The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(32):11212-7.
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2008: Chastagner Patricia; Israël Alain; Brou Christel
AIP4/Itch regulates Notch receptor degradation in the absence of ligand.
PloS one 2008;3(7):e2735.
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2007: Lobry Camille; Lopez Tatiana; Israël Alain; Weil Robert
Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(3):908-13.
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2006: Chastagner Patricia; Israël Alain; Brou Christel
Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains.
EMBO reports 2006;7(11):1147-53.
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2006: Israël Alain
NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.
Trends in immunology 2006;27(9):395-7.
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2006: Weil R; Israël A
Deciphering the pathway from the TCR to NF-kappaB.
Cell death and differentiation 2006;13(5):826-33.
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2006: Kaltschmidt Barbara; Ndiaye Delphine; Korte Martin; Pothion Stéphanie; Arbibe Laurence; Prüllage Maria; Pfeiffer Julia; Lindecke Antje; Staiger Volker; Israël Alain; Kaltschmidt Christian; Mémet Sylvie
NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.
Molecular and cellular biology 2006;26(8):2936-46.
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2006: Vinolo Emilie; Sebban Hélène; Chaffotte Alain; Israël Alain; Courtois Gilles; Véron Michel; Agou Fabrice
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
The Journal of biological chemistry 2006;281(10):6334-48.
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2005: Olry Annie; Chastagner Patricia; Israël Alain; Brou Christel
Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein.
The Journal of biological chemistry 2005;280(31):28564-71.
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2004: Six Emmanuelle M; Ndiaye Delphine; Sauer Guido; Laâbi Yacine; Athman Rafika; Cumano Ana; Brou Christel; Israël Alain; Logeat Frédérique
The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration.
The Journal of biological chemistry 2004;279(53):55818-26.
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2004: Agou Fabrice; Courtois Gilles; Chiaravalli Jeanne; Baleux Françoise; Coïc Yves-Marie; Traincard François; Israël Alain; Véron Michel
Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization.
The Journal of biological chemistry 2004;279(52):54248-57.
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2004: Saban Marcia R; Mémet Sylvie; Jackson David G; Ash John; Roig Aurelio A; Israël Alain; Saban Ricardo
Visualization of lymphatic vessels through NF-kappaB activity.
Blood 2004;104(10):3228-30.
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2004: Fusco Francesca; Bardaro Tiziana; Fimiani Giorgia; Mercadante Vincenzo; Miano Maria Giuseppina; Falco Geppino; Israël Alain; Courtois Gilles; D'Urso Michele; Ursini Matilde Valeria
Molecular analysis of the genetic defect in a large cohort of IP patients and identification of novel NEMO mutations interfering with NF-kappaB activation.
Human molecular genetics 2004;13(16):1763-73.
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2004: Gupta-Rossi Neetu; Six Emmanuelle; LeBail Odile; Logeat Frédérique; Chastagner Patricia; Olry Annie; Israël Alain; Brou Christel
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor.
The Journal of cell biology 2004;166(1):73-83.
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2004: Agou Fabrice; Traincard François; Vinolo Emilie; Courtois Gilles; Yamaoka Shoji; Israël Alain; Véron Michel
The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains.
The Journal of biological chemistry 2004;279(27):27861-9.
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2004: Weil Robert; Israël Alain
T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes.
Current opinion in immunology 2004;16(3):374-81.
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2004: Samson Sandrine I; Mémet Sylvie; Vosshenrich Christian A J; Colucci Francesco; Richard Odile; Ndiaye Delphine; Israël Alain; Di Santo James P
Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation.
Blood 2004;103(12):4573-80.
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2004: Brandt Judith A; Churchill Lynn; Rehman Abdur; Ellis Georgeann; Mémet Sylvie; Israël Alain; Krueger James M
Sleep deprivation increases the activation of nuclear factor kappa B in lateral hypothalamic cells.
Brain research 2004;1004(1-2):91-7.
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2004: Kassed C A; Butler T L; Patton G W; Demesquita D D; Navidomskis M T; Mémet S; Israël A; Pennypacker K R
Injury-induced NF-kappaB activation in the hippocampus: implications for neuronal survival.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(6):723-4.
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2004: Courtois Gilles; Israël Alain
[Human pathologies associated with NF-kappaB defects]
Journal de la Société de biologie 2004;198(2):93-6.
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2003: Goudeau Bertrand; Huetz François; Samson Sandrine; Di Santo James P; Cumano Ana; Beg Amer; Israël Alain; Mémet Sylvie
IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15800-5.
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2003: Fridmacher Valérie; Kaltschmidt Barbara; Goudeau Bertrand; Ndiaye Delphine; Rossi Francesco Mattia; Pfeiffer Julia; Kaltschmidt Christian; Israël Alain; Mémet Sylvie
Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(28):9403-8.
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2003: Courtois Gilles; Smahi Asma; Reichenbach Janine; Döffinger Rainer; Cancrini Caterina; Bonnet Marion; Puel Anne; Chable-Bessia Christine; Yamaoka Shoji; Feinberg Jacqueline; Dupuis-Girod Sophie; Bodemer Christine; Livadiotti Susanna; Novelli Francesco; Rossi Paolo; Fischer Alain; Israël Alain; Munnich Arnold; Le Deist Françoise; Casanova Jean-Laurent
A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency.
The Journal of clinical investigation 2003;112(7):1108-15.
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2003: Schmidt-Supprian Marc; Courtois Gilles; Tian Jane; Coyle Anthony J; Israël Alain; Rajewsky Klaus; Pasparakis Manolis
Mature T cells depend on signaling through the IKK complex.
Immunity 2003;19(3):377-89.
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2003: Kovalenko Andrew; Chable-Bessia Christine; Cantarella Giuseppina; Israël Alain; Wallach David; Courtois Gilles
The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination.
Nature 2003;424(6950):801-5.
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2003: Lilienbaum Alain; Israël Alain
From calcium to NF-kappa B signaling pathways in neurons.
Molecular and cellular biology 2003;23(8):2680-98.
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2003: Weil Robert; Schwamborn Klaus; Alcover Andrés; Bessia Christine; Di Bartolo Vincenzo; Israël Alain
Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor.
Immunity 2003;18(1):13-26.
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2002: Smahi Asma; Courtois Gilles; Rabia Smail Hadj; Döffinger Rainer; Bodemer Christine; Munnich Arnold; Casanova Jean-Laurent; Israël Alain
The NF-kappaB signalling pathway in human diseases: from incontinentia pigmenti to ectodermal dysplasias and immune-deficiency syndromes.
Human molecular genetics 2002;11(20):2371-5.
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2002: Kayal Samer; Lilienbaum Alain; Join-Lambert Olivier; Li Xiaoxia; Israël Alain; Berche Patrick
Listeriolysin O secreted by Listeria monocytogenes induces NF-kappaB signalling by activating the IkappaB kinase complex.
Molecular microbiology 2002;44(5):1407-19.
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2002: Agou Fabrice; Ye Fei; Goffinont Stéphane; Courtois Gilles; Yamaoka Shoji; Israël Alain; Véron Michel
NEMO trimerizes through its coiled-coil C-terminal domain.
The Journal of biological chemistry 2002;277(20):17464-75.
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2002: Alaoui-El-Azher Mounia; Wu Yongzheng; Havet Nathalie; Israël Alain; Lilienbaum Alain; Touqui Lhousseine
Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways.
Molecular pharmacology 2002;61(4):786-94.
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2001: Courtois G; Smahi A; Israël A
NEMO/IKK gamma: linking NF-kappa B to human disease.
Trends in molecular medicine 2001;7(10):427-30.
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2001: Gupta-Rossi N; Le Bail O; Gonen H; Brou C; Logeat F; Six E; Ciechanover A; Israël A
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.
The Journal of biological chemistry 2001;276(37):34371-8.
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2001: Brou C; Israël A
Presenilins.
Current biology : CB 2001;11(14):R543.
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2001: Ciechanover A; Gonen H; Bercovich B; Cohen S; Fajerman I; Israël A; Mercurio F; Kahana C; Schwartz A L; Iwai K; Orian A
Mechanisms of ubiquitin-mediated, limited processing of the NF-kappaB1 precursor protein p105.
Biochimie 2001;83(3-4):341-9.
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2001: Döffinger R; Smahi A; Bessia C; Geissmann F; Feinberg J; Durandy A; Bodemer C; Kenwrick S; Dupuis-Girod S; Blanche S; Wood P; Rabia S H; Headon D J; Overbeek P A; Le Deist F; Holland S M; Belani K; Kumararatne D S; Fischer A; Shapiro R; Conley M E; Reimund E; Kalhoff H; Abinun M; Munnich A; Israël A; Courtois G; Casanova J L
X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling.
Nature genetics 2001;27(3):277-85.
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2001: Aradhya S; Courtois G; Rajkovic A; Lewis R A; Levy M; Israël A; Nelson D L
Atypical forms of incontinentia pigmenti in male individuals result from mutations of a cytosine tract in exon 10 of NEMO (IKK-gamma).
American journal of human genetics 2001;68(3):765-71.
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2000: Courtois G; Israël A
NF-kappa B defects in humans: the NEMO/incontinentia pigmenti connection.
Science's STKE : signal transduction knowledge environment 2000;2000(58):pe1.
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2000: Lilienbaum A; Sage J; Mémet S; Rassoulzadegan M; Cuzin F; Israël A
NF-kappa B is developmentally regulated during spermatogenesis in mice.
Developmental dynamics : an official publication of the American Association of Anatomists 2000;219(3):333-40.
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2000: Schwamborn K; Weil R; Courtois G; Whiteside S T; Israël A
Phorbol esters and cytokines regulate the expression of the NEMO-related protein, a molecule involved in a NF-kappa B-independent pathway.
The Journal of biological chemistry 2000;275(30):22780-9.
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2000: Schmidt-Supprian M; Bloch W; Courtois G; Addicks K; Israël A; Rajewsky K; Pasparakis M
NEMO/IKK gamma-deficient mice model incontinentia pigmenti.
Molecular cell 2000;5(6):981-92.
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2000: Orian A; Gonen H; Bercovich B; Fajerman I; Eytan E; Israël A; Mercurio F; Iwai K; Schwartz A L; Ciechanover A
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase.
The EMBO journal 2000;19(11):2580-91.
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2000: Smahi A; Courtois G; Vabres P; Yamaoka S; Heuertz S; Munnich A; Israël A; Heiss N S; Klauck S M; Kioschis P; Wiemann S; Poustka A; Esposito T; Bardaro T; Gianfrancesco F; Ciccodicola A; D'Urso M; Woffendin H; Jakins T; Donnai D; Stewart H; Kenwrick S J; Aradhya S; Yamagata T; Levy M; Lewis R A; Nelson D L
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium.
Nature 2000;405(6785):466-72.
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2000: Feuillard J; Mémet S; Goudeau B; Lilienbaum A; Schmidt-Ullrich R; Raphaël M; Israël A
In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-kappaB/Rel complexes.
International immunology 2000;12(5):613-21.
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2000: Israël A
The IKK complex: an integrator of all signals that activate NF-kappaB?
Trends in cell biology 2000;10(4):129-33.
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2000: Brou C; Logeat F; Gupta N; Bessia C; LeBail O; Doedens J R; Cumano A; Roux P; Black R A; Israël A
A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.
Molecular cell 2000;5(2):207-16.
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1999: Mémet S; Laouini D; Epinat J C; Whiteside S T; Goudeau B; Philpott D; Kayal S; Sansonetti P J; Berche P; Kanellopoulos J; Israël A
IkappaBepsilon-deficient mice: reduction of one T cell precursor subspecies and enhanced Ig isotype switching and cytokine synthesis.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(11):5994-6005.
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1999: Weil R; Sirma H; Giannini C; Kremsdorf D; Bessia C; Dargemont C; Bréchot C; Israël A
Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha.
Molecular and cellular biology 1999;19(9):6345-54.
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1999: Orian A; Schwartz A L; Israël A; Whiteside S; Kahana C; Ciechanover A
Structural motifs involved in ubiquitin-mediated processing of the NF-kappaB precursor p105: roles of the glycine-rich region and a downstream ubiquitination domain.
Molecular and cellular biology 1999;19(5):3664-73.
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1999: Weil R; Levraud J P; Dodon M D; Bessia C; Hazan U; Kourilsky P; Israël A
Altered expression of tyrosine kinases of the Src and Syk families in human T-cell leukemia virus type 1-infected T-cell lines.
Journal of virology 1999;73(5):3709-17.
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1998: Logeat F; Bessia C; Brou C; LeBail O; Jarriault S; Seidah N G; Israël A
The Notch1 receptor is cleaved constitutively by a furin-like convertase.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8108-12.
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1998: Yamaoka S; Courtois G; Bessia C; Whiteside S T; Weil R; Agou F; Kirk H E; Kay R J; Israël A
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.
Cell 1998;93(7):1231-40.
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1998: Sirma H; Weil R; Rosmorduc O; Urban S; Israël A; Kremsdorf D; Bréchot C
Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome.
Oncogene 1998;16(16):2051-63.
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1997: Weil R; Whiteside S T; Israël A
Control of NF-kappa B activity by the I kappa B beta inhibitor.
Immunobiology 1997;198(1-3):14-23.
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1997: Schouten G J; Vertegaal A C; Whiteside S T; Israël A; Toebes M; Dorsman J C; van der Eb A J; Zantema A
IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase.
The EMBO journal 1997;16(11):3133-44.
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1997: Epinat J C; Whiteside S T; Rice N R; Israël A
Reconstitution of the NF-kappa B system in Saccharomyces cerevisiae for isolation of effectors by phenotype modulation.
Yeast (Chichester, England) 1997;13(7):599-612.
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1997: Whiteside S T; Israël A
I kappa B proteins: structure, function and regulation.
Seminars in cancer biology 1997;8(2):75-82.
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1997: Weil R; Laurent-Winter C; Israël A
Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha.
The Journal of biological chemistry 1997;272(15):9942-9.
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1997: Whiteside S T; Epinat J C; Rice N R; Israël A
I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
The EMBO journal 1997;16(6):1413-26.
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1996: MacKichan M L; Logeat F; Israël A
Phosphorylation of p105 PEST sequence via a redox-insensitive pathway up-regulates processing of p50 NF-kappaB.
The Journal of biological chemistry 1996;271(11):6084-91.
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1995: Whiteside S T; Ernst M K; LeBail O; Laurent-Winter C; Rice N; Israël A
N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activity.
Molecular and cellular biology 1995;15(10):5339-45.
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1995: Munoz E; Israël A
Activation of NF-kappa B by the Tax protein of HTLV-1.
Immunobiology 1995;193(2-4):128-36.
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1995: Israël A
A role for phosphorylation and degradation in the control of NF-kappa B activity.
Trends in genetics : TIG 1995;11(6):203-5.
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1994: Muñoz E; Courtois G; Veschambre P; Jalinot P; Israël A
Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.
Journal of virology 1994;68(12):8035-44.
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1994: Brou C; Logeat F; Lecourtois M; Vandekerckhove J; Kourilsky P; Schweisguth F; Israël A
Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.
Genes & development 1994;8(20):2491-503.
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1993: Le Bail O; Schmidt-Ullrich R; Israël A
Promoter analysis of the gene encoding the I kappa B-alpha/MAD3 inhibitor of NF-kappa B: positive regulation by members of the rel/NF-kappa B family.
The EMBO journal 1993;12(13):5043-9.
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1993: Ten R M; Blank V; Le Bail O; Kourilsky P; Israël A
Two factors, IRF1 and KBF1/NF-kappa B, cooperate during induction of MHC class I gene expression by interferon alpha beta or Newcastle disease virus.
Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie 1993;316(5):496-501.
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1992: Lattion A L; Espel E; Reichenbach P; Fromental C; Bucher P; Israël A; Baeuerle P; Rice N R; Nabholz M
Characterization of a new tissue-specific transcription factor binding to the simian virus 40 enhancer TC-II (NF-kappa B) element.
Molecular and cellular biology 1992;12(11):5217-27.
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1992: Rice N R; MacKichan M L; Israël A
The precursor of NF-kappa B p50 has I kappa B-like functions.
Cell 1992;71(2):243-53.
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1992: Blank V; Kourilsky P; Israël A
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats.
Trends in biochemical sciences 1992;17(4):135-40.
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1992: Ten R M; Paya C V; Israël N; Le Bail O; Mattei M G; Virelizier J L; Kourilsky P; Israël A
The characterization of the promoter of the gene encoding the p50 subunit of NF-kappa B indicates that it participates in its own regulation.
The EMBO journal 1992;11(1):195-203.
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1991: Blank V; Kourilsky P; Israël A
Cytoplasmic retention, DNA binding and processing of the NF-kappa B p50 precursor are controlled by a small region in its C-terminus.
The EMBO journal 1991;10(13):4159-67.
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1991: Logeat F; Israël N; Ten R; Blank V; Le Bail O; Kourilsky P; Israël A
Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.
The EMBO journal 1991;10(7):1827-32.
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1991: Rivière Y; Blank V; Kourilsky P; Israël A
Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infection.
Nature 1991;350(6319):625-6.
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1991: Hémar A; Cereghini S; Cornet V; Blank V; Israël A; Greene W C; Dautry-Varsat A
Kappa B binding proteins are constitutively expressed in an IL-2 autocrine human T cell line.
Journal of immunology (Baltimore, Md. : 1950) 1991;146(7):2409-16.
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1990: Kieran M; Blank V; Logeat F; Vandekerckhove J; Lottspeich F; Le Bail O; Urban M B; Kourilsky P; Baeuerle P A; Israël A
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.
Cell 1990;62(5):1007-18.
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1990: David-Watine B; Israël A; Kourilsky P
The regulation and expression of MHC class I genes.
Immunology today 1990;11(8):286-92.
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1989: Israël N; Hazan U; Alcami J; Munier A; Arenzana-Seisdedos F; Bachelerie F; Israël A; Virelizier J L
Tumor necrosis factor stimulates transcription of HIV-1 in human T lymphocytes, independently and synergistically with mitogens.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):3956-60.
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1989: Israël A; Le Bail O; Hatat D; Piette J; Kieran M; Logeat F; Wallach D; Fellous M; Kourilsky P
TNF stimulates expression of mouse MHC class I genes by inducing an NF kappa B-like enhancer binding activity which displaces constitutive factors.
The EMBO journal 1989;8(12):3793-800.
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1987: Yano O; Kanellopoulos J; Kieran M; Le Bail O; Israël A; Kourilsky P
Purification of KBF1, a common factor binding to both H-2 and beta 2-microglobulin enhancers.
The EMBO journal 1987;6(11):3317-24.
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1987: Israël A; Kimura A; Kieran M; Yano O; Kanellopoulos J; Le Bail O; Kourilsky P
A common positive trans-acting factor binds to enhancer sequences in the promoters of mouse H-2 and beta 2-microglobulin genes.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(9):2653-7.
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1986: Kimura A; Israël A; Le Bail O; Kourilsky P
Detailed analysis of the mouse H-2Kb promoter: enhancer-like sequences and their role in the regulation of class I gene expression.
Cell 1986;44(2):261-72.
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