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Jean-Pierre Issa

Research Profile

Physiology

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Publications

TOP 3
Jean-Pierre J Issa
The myelodysplastic syndrome as a prototypical epigenetic disease.
Jumpei Yamazaki; Jean-Pierre J Issa
Epigenetic aspects of MDS and its molecular targeted therapy.
Jumpei Yamazaki; Marcos R Estecio; David Graber; Yujia Huo; Jaroslav Jelinek; Steven M Kornblau; Shoudan Liang; Hai Long; Yue Lu; Gabriel G Malouf; Louis S Ramagli; Jean-Pierre J Issa
The epigenome of AML stem and progenitor cells.

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All Publications

2013: Jean-Pierre J Issa
The myelodysplastic syndrome as a prototypical epigenetic disease.
Blood 2013;121(19):3811-7.
2013: Jumpei Yamazaki; Jean-Pierre J Issa
Epigenetic aspects of MDS and its molecular targeted therapy.
International journal of hematology 2013;97(2):175-82.
2013: Jumpei Yamazaki; Marcos R Estecio; David Graber; Yujia Huo; Jaroslav Jelinek; Steven M Kornblau; Shoudan Liang; Hai Long; Yue Lu; Gabriel G Malouf; Louis S Ramagli; Jean-Pierre J Issa
The epigenome of AML stem and progenitor cells.
Epigenetics : official journal of the DNA Methylation Society 2013;8(1):92-104.
2012: Jaroslav Jelinek; Shoudan Liang; Yue Lu; Louis S Ramagli; Elizabeth J Shpall; Marcos R H Estecio; Rong He; Jean-Pierre J Issa
Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique.
Epigenetics : official journal of the DNA Methylation Society 2012;7(12):1368-78.
2012: Y Boumber; R Castoro; Jorge Cortes; Zeev Estrov; Stefan Faderl; Guillermo Garcia-Manero; Jean-Pierre J Issa; Elias Jabbour; J Jorgensen; Andrew Lamb; J Autry; Gautam Borthakur; S Wen; Farhad Ravandi
A randomized study of decitabine versus conventional care for maintenance therapy in patients with acute myeloid leukemia in complete remission.
Leukemia 2012;26(11):2428-31.
2012: Marcos R H Estécio; Juan Gallegos; Shoudan Liang; Yue Lu; Mhair Dekmezian; Jean-Pierre J Issa
SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters.
Molecular cancer research : MCR 2012;10(10):1332-42.
2012: Cornelia M Ulrich; Catherine Duggan; Lisel M Koepl; Anne McTiernan; Elizabeth M Poole; Tracy Sandifer; Adetunji T Toriola; Jean-Pierre J Issa
Metabolic, hormonal and immunological associations with global DNA methylation among postmenopausal women.
Epigenetics : official journal of the DNA Methylation Society 2012;7(9):1020-8.
2012: Yan Zhang; Marcos R H Estecio; Lanlan Shen; Jingmin Shu; Jiali Si; Jean-Pierre J Issa
Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island.
Nucleic acids research 2012;40(15):7257-68.
2012: Jean-Pierre J Issa
DNA methylation as a clinical marker in oncology.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(20):2566-8.
2012: Anjana Bhardwaj; Ryan Castoro; Frank Claessens; Karel De Gendt; Stefanie Kerkhofs; Marie-Claire Orgebin-Crist; Sreenath Shanker; Hye-Won Song; Kichiya Suzuki; Marcy Beildeck; Jean-Pierre J Issa; Miles F Wilkinson
DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis.
Molecular endocrinology (Baltimore, Md.) 2012;26(4):538-49.
2012: Hsing-Chen Tsai; Leander Van Neste; Alana L Welm; Lonny Brett Yarmus; Ray-Whay Chiu Yen; NITA AHUJA; Stephen B Baylin; ROBERT BEATY; Malcolm V Brock; Yi Cai; DAVID FELLER-KOPMAN; Kirsten M Harbom; James Harris; Jean-Pierre J Issa; YOON YOUNG JANG; Huili Li; Yi-Chun Lin; William Matsui; Il Minn; Emmanouil Pappou; Feyruz V Rassool; Carine Robert; Saul J Sharkis; James J Shin; Vered Stearns; Cynthia A Zahnow
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells.
Cancer cell 2012;21(3):430-46.
2012: Noël J-M Raynal; Jiali Si; Rodolphe F Taby; Jaroslav Jelinek; Saira Ahmed; Marcos R H Estécio; Vazganush Gharibyan; Jean-Pierre J Issa
DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory.
Cancer research 2012;72(5):1170-81.
2012: Jumpei Yamazaki; Marcos R Estecio; Lucy A Godley; Jaroslav Jelinek; Hagop M Kantarjian; Trisha Macrae; Kelly R Ostler; Lanlan Shen; Rodolphe Taby; Aparna Vasanthakumar; Jean-Pierre J Issa
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
Epigenetics : official journal of the DNA Methylation Society 2012;7(2):201-7.
2012: Jia Xu; Robert C Bast; Carol Chenault; Weiwei Feng; Susan G Hilsenbeck; Jean-Pierre J Issa; Priya B Shetty; Yinhua Yu
Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome.
BMC cancer 2012;12():243.
2012: Grant A Challen; Christoph Bock; Gretchen J Darlington; Lucy A Godley; Yuanxin Xi; Mira Jeong; Jonathan S Berg; Hongcang Gu; Yue Lu; Alexander Meissner; Shoudan Liang; Wei Li; Jean-Pierre J Issa; Deqiang Sun; Jaroslav Jelinek; Aparna Vasanthakumar; Min Luo; Margaret A Goodell
Dnmt3a is essential for hematopoietic stem cell differentiation.
Nature genetics 2012;44(1):23-31.
2011: Jean-Pierre J Issa
Epigenetic variation and cellular Darwinism.
Nature genetics 2011;43(8):724-6.
2011: Jean-Pierre J Issa; Wilhelm Just
Epigenetics.
FEBS letters 2011;585(13):1993.
2011: Marcos R H Estécio; Jean-Pierre J Issa
Dissecting DNA hypermethylation in cancer.
FEBS letters 2011;585(13):2078-86.
2011: Woonbok Chung; Bogdan Czerniak; Jaroslav Jelinek; Shoudan Liang; Yair Lotan; Jolanta Bondaruk; Jean-Pierre J Issa
Detection of bladder cancer using novel DNA methylation biomarkers in urine sediments.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2011;20(7):1483-91.
2011: Thushangi N Pathiraja; Priya B Shetty; Ryan Hartmaier; Rong He; Susan G Hilsenbeck; Jean-Pierre J Issa; Jaroslav Jelinek; Astrid L Margossian; Steffi Oesterreich
Progesterone receptor isoform-specific promoter methylation: association of PRA promoter methylation with worse outcome in breast cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(12):4177-86.
2011: Lucia Fini; Giulia Piazzi; Yahya Daoud; Michael Selgrad; Shinji Maegawa; Melissa Garcia; Vincenzo Fogliano; Marco Romano; Giulia Graziani; Paola Vitaglione; Susanne W Carmack; Antonio Gasbarrini; Robert M Genta; Jean-Pierre J Issa; C Richard Boland; Luigi Ricciardiello
Chemoprevention of intestinal polyps in ApcMin/+ mice fed with western or balanced diets by drinking annurca apple polyphenol extract.
Cancer prevention research (Philadelphia, Pa.) 2011;4(6):907-15.
2011: Joong Bae Ahn; Woon Bok Chung; Osamu Maeda; Sang Joon Shin; Hyun Soo Kim; Hyun Chul Chung; Nam Kyu Kim; Jean-Pierre J Issa
DNA methylation predicts recurrence from resected stage III proximal colon cancer.
Cancer 2011;117(9):1847-54.
2011: David Cogdell; Woonbok Chung; Yuexin Liu; J Matthew McDonald; Kenneth Aldape; Jean-Pierre J Issa; Gregory N Fuller; Wei Zhang
Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma.
Chinese journal of cancer 2011;30(4):247-53.
2011: Yanis Boumber; Jean-Pierre J Issa
Epigenetics in cancer: what's the future?
Oncology (Williston Park, N.Y.) 2011;25(3):220-6, 228.
2011: Astrid Spannhoff; Yong Kee Kim; Noel J-M Raynal; Vazganush Gharibyan; Ming-Bo Su; Yue-Yang Zhou; Jia Li; Sabrina Castellano; Gianluca Sbardella; Jean-Pierre J Issa; Mark T Bedford
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees.
EMBO reports 2011;12(3):238-43.
2011: Kazuo Konishi; Shinji Maegawa; Lanlan Shen; Yoshiyuki Watanabe; Fumio Itoh; Jaroslav Jelinek; Kimie Kondo; Yutaka Kondo; Saira Ahmed; Yanis A Boumber; Ryan J Castoro; Woonbok Chung; Marcos R H Estecio; Yi Guo; Stanley R Hamilton; Michio Imawari; Jean-Pierre J Issa
DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis.
PloS one 2011;6(11):e27889.
2011: Taichun Qin; Jingmin Shu; Jiali Si; Xiaodan Wang; Nianxiang Zhang; Ryan Castoro; Woonbok Chung; Samih El Ahdab; Rong He; Jaroslav Jelinek; Hagop M Kantarjian; Jean-Pierre J Issa
Mechanisms of resistance to decitabine in the myelodysplastic syndrome.
PloS one 2011;6(8):e23372.
2011: Yoshiyuki Watanabe; Saira S Ahmed; Ryan J Castoro; Mee-Yon Cho; Woonbok Chung; Marcos R H Estecio; Tetsuya Hiraishi; Fumio Itoh; Jaroslav Jelinek; Hyun Soo Kim; Brittany North; Ritsuko Oikawa; Lanlan Shen; Minoru Toyota; Jean-Pierre J Issa
Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.
PloS one 2011;6(8):e23320.
2011: Jaroslav Jelinek; Hagop M Kantarjian; Kimie Kondo; Shoudan Liang; Yue Lu; Nianxiang Zhang; Woonbok Chung; Jorge E Cortes; Marcos R H Estecio; Vazganush Gharibyan; Rong He; Jean-Pierre J Issa
Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia.
PloS one 2011;6(7):e22110.
2011: Jean-Pierre J Issa; Judy E Garber
Time to think outside the (genetic) box.
Cancer prevention research (Philadelphia, Pa.) 2011;4(1):6-8.
2010: Kristin Wallace; Maria V Grau; A Joan Levine; Lanlan Shen; Randala Hamdan; Xinli Chen; Jiang Gui; Robert W Haile; Elizabeth L Barry; Dennis Ahnen; Gail McKeown-Eyssen; John A Baron; Jean-Pierre J Issa
Association between folate levels and CpG Island hypermethylation in normal colorectal mucosa.
Cancer prevention research (Philadelphia, Pa.) 2010;3(12):1552-64.
2010: Rodolphe Taby; Jean-Pierre J Issa
Cancer epigenetics.
CA: a cancer journal for clinicians 2010;60(6):376-92.
2010: Byonggu An; Yutaka Kondo; Yasuyuki Okamoto; Keiko Shinjo; Yukihide Kanemitsu; Koji Komori; Takashi Hirai; Akira Sawaki; Masahiro Tajika; Tsuneya Nakamura; Kenji Yamao; Yasushi Yatabe; Makiko Fujii; Hideki Murakami; Hirotaka Osada; Tohru Tani; Keitaro Matsuo; Lanlan Shen; Jean-Pierre J Issa; Yoshitaka Sekido
Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancers.
International journal of cancer. Journal international du cancer 2010;127(9):2095-105.
2010: Marcos R H Estécio; Juan Gallegos; Céline Vallot; Ryan J Castoro; Woonbok Chung; Shinji Maegawa; Yasuhiro Oki; Yutaka Kondo; Jaroslav Jelinek; Lanlan Shen; Helge Hartung; Peter D Aplan; Bogdan A Czerniak; Shoudan Liang; Jean-Pierre J Issa
Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer.
Genome research 2010;20(10):1369-82.
2010: Ulrich Mahlknecht; Jean-Pierre J Issa
Introductory editorial.
Clinical epigenetics 2010;1(1-2):1.
2010: Jiali Si; Yanis A Boumber; Jingmin Shu; Taichun Qin; Saira Ahmed; Rong He; Jaroslav Jelinek; Jean-Pierre J Issa
Chromatin remodeling is required for gene reactivation after decitabine-mediated DNA hypomethylation.
Cancer research 2010;70(17):6968-77.
2010: Elias Jabbour; Guillermo Garcia-Manero; Nicolas Batty; Jenny Shan; Susan O'Brien; Jorge Cortes; Farhad Ravandi; Jean-Pierre J Issa; Andrew Lamb
Outcome of patients with myelodysplastic syndrome after failure of decitabine therapy.
Cancer 2010;116(16):3830-4.
2010: Jeffrey Bryan; Elias Jabbour; Hillary Prescott; Guillermo Garcia-Manero; Jean-Pierre J Issa; Andrew Lamb
Current and future management options for myelodysplastic syndromes.
Drugs 2010;70(11):1381-94.
2010: Bernard Kwabi-Addo; Songping Wang; Woonbok Chung; Jaroslav Jelinek; Steven R Patierno; Bi-Dar Wang; Ramez Andrawis; Norman H Lee; Victor Apprey; Jean-Pierre J Issa; Michael Ittmann
Identification of differentially methylated genes in normal prostate tissues from African American and Caucasian men.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(14):3539-47.
2010: G Nicolas Batty; Andrew Lamb; Jean-Pierre J Issa; Elias Jabbour; Fabio P S Santos; Deborah McCue; Guillermo Garcia-Manero; Sherry Pierce; Susan O'Brien; Jorge E Cortés; Farhad Ravandi
Feasibility of therapy with hypomethylating agents in patients with renal insufficiency.
Clinical lymphoma, myeloma & leukemia 2010;10(3):205-10.
2010: C Cleyrat; J Jelinek; F Girodon; M Boissinot; T Ponge; Jean-Luc Harousseau; Jean-Pierre J Issa; Sylvie Hermouet
JAK2 mutation and disease phenotype: a double L611V/V617F in cis mutation of JAK2 is associated with isolated erythrocytosis and increased activation of AKT and ERK1/2 rather than STAT5.
Leukemia 2010;24(5):1069-73.
2010: Jean-Pierre J Issa
Epigenetic changes in the myelodysplastic syndrome.
Hematology/oncology clinics of North America 2010;24(2):317-30.
2010: Shinji Maegawa; George Hinkal; Hyun Soo Kim; Lanlan Shen; Li Zhang; Jiexin Zhang; Nianxiang Zhang; Shoudan Liang; Lawrence A Donehower; Jean-Pierre J Issa
Widespread and tissue specific age-related DNA methylation changes in mice.
Genome research 2010;20(3):332-40.
2010: Hiromu Suzuki; Shinichi Igarashi; Masanori Nojima; REO MARUYAMA; Eiichiro Yamamoto; Masahiro Kai; Hirofumi Akashi; Yoshiyuki Watanabe; Hiroyuki Yamamoto; Yasushi Sasaki; Fumio Itoh; Kohzoh Imai; Tamotsu Sugai; Lanlan Shen; Jean-Pierre J Issa; Yasuhisa Shinomura; Takashi Tokino; Minoru Toyota
IGFBP7 is a p53-responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.
Carcinogenesis 2010;31(3):342-9.
2010: Lanlan Shen; Andrew Lamb; Yi Guo; Edward Lin; Jianqin Shan; Xuelin Huang; Donald Berry; Saira Ahmed; Wei Zhu; Sherry Pierce; Yutaka Kondo; Yasuhiro Oki; Jaroslav Jelinek; Hussain Saba; Eli Estey; Jean-Pierre J Issa
DNA methylation predicts survival and response to therapy in patients with myelodysplastic syndromes.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(4):605-13.
2010: Yutaka Kondo; Jean-Pierre J Issa
DNA methylation profiling in cancer.
Expert reviews in molecular medicine 2010;12():e23.
2010: Yasuhiro Oki; Jean-Pierre J Issa
Epigenetic mechanisms in AML - a target for therapy.
Cancer treatment and research 2010;145():19-40.
2010: Gautam Borthakur; Xuelin Huang; Andrew Lamb; Stefan Faderl; Farhad Ravandi; Alessandra Ferrajoli; Ritva Torma; Gail Morris; Donald Berry; Jean-Pierre J Issa
Report of a phase 1/2 study of a combination of azacitidine and cytarabine in acute myelogenous leukemia and high-risk myelodysplastic syndromes.
Leukemia & lymphoma 2010;51(1):73-8.
2010: Fabio P S Santos; Andrew Lamb; Guillermo Garcia-Manero; Jean-Pierre J Issa; Farhad Ravandi
Decitabine in the treatment of myelodysplastic syndromes.
Expert review of anticancer therapy 2010;10(1):9-22.
2009: Farhad Ravandi; Jean-Pierre J Issa; Guillermo Garcia-Manero; Susan O'Brien; Sherry Pierce; Jianqin Shan; Gautam Borthakur; Srdan Verstovsek; Stefan Faderl; Jorge Cortes; Andrew Lamb
Superior outcome with hypomethylating therapy in patients with acute myeloid leukemia and high-risk myelodysplastic syndrome and chromosome 5 and 7 abnormalities.
Cancer 2009;115(24):5746-51.
2009: Yasuhiro Goto; Keiko Shinjo; Yutaka Kondo; Lanlan Shen; Minoru Toyota; Hiromu Suzuki; Wentao Gao; Byonggu An; Makiko Fujii; Hideki Murakami; Hirotaka Osada; Tetsuo Taniguchi; Noriyasu Usami; Masashi Kondo; Yoshinori Hasegawa; Kaoru Shimokata; Keitaro Matsuo; Toyoaki Hida; Nobukazu Fujimoto; Takumi Kishimoto; Jean-Pierre J Issa; Yoshitaka Sekido
Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma.
Cancer research 2009;69(23):9073-82.
2009: Andrew Lamb; Susan O'Brien; Farhad Ravandi; Gautam Borthakur; Stefan Faderl; Carlos E Bueso-Ramos; Lynne V Abruzzo; Sherry Pierce; Jianqin Shan; Jean-Pierre J Issa; Guillermo Garcia-Manero
The heterogeneous prognosis of patients with myelodysplastic syndrome and chromosome 5 abnormalities: how does it relate to the original lenalidomide experience in MDS?
Cancer 2009;115(22):5202-9.
2009: Kazuo Konishi; Lanlan Shen; Jaroslav Jelinek; Yoshiyuki Watanabe; Saira Ahmed; Kazuhiro Kaneko; Mari Kogo; Toshihumi Takano; Michio Imawari; Stanley R Hamilton; Jean-Pierre J Issa
Concordant DNA methylation in synchronous colorectal carcinomas.
Cancer prevention research (Philadelphia, Pa.) 2009;2(9):814-22.
2009: S Heinrichs; R V Kulkarni; C E Bueso-Ramos; Ross Levine; Mignon L Loh; Cheng Li; Donna Neuberg; Steven M Kornblau; Jean-Pierre J Issa; D Gary Gilliland; G Garcia-Manero; H M Kantarjian; Elihu H Estey; A Thomas Look
Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics.
Leukemia 2009;23(9):1605-13.
2009: Mignon L Loh; Debbie S Sakai; Christian Flotho; Michelle Kang; Manfred Fliegauf; Sophie Archambeault; Charles G Mullighan; Leslie Chen; Eva Bergstraesser; Carlos E Bueso-Ramos; Peter D Emanuel; Henrik Hasle; Jean-Pierre J Issa; Marry M van den Heuvel-Eibrink; Franco Locatelli; Jan Stary; Monika M Trebo; Marcin Wlodarski; Marco Zecca; Kevin Shannon; Charlotte M Niemeyer
Mutations in CBL occur frequently in juvenile myelomonocytic leukemia.
Blood 2009;114(9):1859-63.
2009: Nicolas Batty; Gabriel G Malouf; Jean-Pierre J Issa
Histone deacetylase inhibitors as anti-neoplastic agents.
Cancer letters 2009;280(2):192-200.
2009: Jean-Pierre J Issa; Hagop M Kantarjian
Targeting DNA methylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):3938-46.
2009: David J Stewart; Jean-Pierre J Issa; Razelle Kurzrock; Maria I Nunez; Jaroslav Jelinek; David Hong; Yasuhiro Oki; Zhong Guo; Sanjay Gupta; Ignacio I Wistuba
Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(11):3881-8.
2009: Carmen S Tellez; Lanlan Shen; Marcos R H Estécio; Jaroslav Jelinek; jeffrey gershenwald; Jean-Pierre J Issa
CpG island methylation profiling in human melanoma cell lines.
Melanoma research 2009;19(3):146-55.
2009: Yoshiyuki Watanabe; Hyun Soo Kim; Ryan J Castoro; Woonbok Chung; Marcos R H Estecio; Kimie Kondo; Yi Guo; Saira S Ahmed; Minoru Toyota; Fumio Itoh; Ki Tae Suk; Mee-Yon Cho; Lanlan Shen; Jaroslav Jelinek; Jean-Pierre J Issa
Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes.
Gastroenterology 2009;136(7):2149-58.
2009: L De Padua Silva; Marcos De Lima; Andrew Lamb; Stefan Faderl; Partow Kebriaei; Sergio Giralt; Jan Davisson; Guillermo Garcia-Manero; Richard Champlin; Jean-Pierre J Issa; Farhad Ravandi
Feasibility of allo-SCT after hypomethylating therapy with decitabine for myelodysplastic syndrome.
Bone marrow transplantation 2009;43(11):839-43.
2009: Xuelin Huang; Jing Ning; Yisheng Li; Elihu Estey; Jean-Pierre J Issa; Donald A Berry
Using short-term response information to facilitate adaptive randomization for survival clinical trials.
Statistics in medicine 2009;28(12):1680-9.
2009: Carol B Ware; Linlin Wang; Brigham H Mecham; Lanlan Shen; Angelique M Nelson; Merav Bar; Deepak A Lamba; Derek S Dauphin; Brian Buckingham; Bardia Askari; Raymond Lim; Muneesh Tewari; Stanley M Gartler; Jean-Pierre J Issa; Paul Pavlidis; Zhijun Duan; C Anthony Blau
Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells.
Cell stem cell 2009;4(4):359-69.
2009: Ana Aparicio; Brittany North; Lindsey Barske; Xuemei Wang; Valentina Bollati; Daniel Weisenberger; Christine Yoo; Nizar M Tannir; Erin Horne; Susan Groshen; Peter Jones; Allen Yang; Jean-Pierre J Issa
LINE-1 methylation in plasma DNA as a biomarker of activity of DNA methylation inhibitors in patients with solid tumors.
Epigenetics : official journal of the DNA Methylation Society 2009;4(3):176-84.
2009: Jane C Figueiredo; Maria V Grau; Kristin Wallace; A Joan Levine; Lanlan Shen; Randala Hamdan; Xinli Chen; Robert S Bresalier; Gail McKeown-Eyssen; Robert W Haile; John A Baron; Jean-Pierre J Issa
Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009;18(4):1041-9.
2009: Mi-Jung Kim; Jill A White-Cross; Lanlan Shen; Jean-Pierre J Issa; Asif Rashid
Hypomethylation of long interspersed nuclear element-1 in hepatocellular carcinomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2009;22(3):442-9.
2009: Taichun Qin; Jaroslav Jelinek; Jiali Si; Jingmin Shu; Jean-Pierre J Issa
Mechanisms of resistance to 5-aza-2'-deoxycytidine in human cancer cell lines.
Blood 2009;113(3):659-67.
2009: Shoudan Liang; Yue Lu; Jaroslav Jelinek; Marcos Estecio; Hao Li; Jean-Pierre J Issa
Analysis of epigenetic modifications by next generation sequencing.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference 2009;2009():6730.
2009: Marcos Rh Estécio; Jean-Pierre J Issa
Tackling the methylome: recent methodological advances in genome-wide methylation profiling.
Genome medicine 2009;1(11):106.
2008: Marcel H A M Fens; K J Hill; Jean-Pierre J Issa; S E Ashton; F R Westwood; D C Blakey; Gert Storm; Anderson Ryan; Raymond Schiffelers
Liposomal encapsulation enhances the antitumour efficacy of the vascular disrupting agent ZD6126 in murine B16.F10 melanoma.
British journal of cancer 2008;99(8):1256-64.
2008: Jean-Pierre J Issa
Colon cancer: it's CIN or CIMP.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(19):5939-40.
2008: Andrew Lamb; Susan O'Brien; Jorge Cortes; William G Wierda; Stefan Faderl; Guillermo Garcia-Manero; Jean-Pierre J Issa; Elihu Estey; Michael Keating; Emil J Freireich
Therapeutic advances in leukemia and myelodysplastic syndrome over the past 40 years.
Cancer 2008;113(7 Suppl):1933-52.
2008: Wentao Gao; Yutaka Kondo; Lanlan Shen; Yasuhiro Shimizu; Tsuyoshi Sano; Kenji Yamao; Atsushi Natsume; Yasuhiro Goto; Motokazu Ito; Hideki Murakami; Hirotaka Osada; Jiexin Zhang; Jean-Pierre J Issa; Yoshitaka Sekido
Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas.
Carcinogenesis 2008;29(10):1901-10.
2008: Andrew Lamb; Susan O'Brien; Farhad Ravandi; Jorge Cortes; Jianqin Shan; John M Bennett; Alan F List; Pierre Fenaux; Guillermo Sanz; Jean-Pierre J Issa; Emil J Freireich; Guillermo Garcia-Manero
Proposal for a new risk model in myelodysplastic syndrome that accounts for events not considered in the original International Prognostic Scoring System.
Cancer 2008;113(6):1351-61.
2008: Jean-Pierre J Issa
Cancer prevention: epigenetics steps up to the plate.
Cancer prevention research (Philadelphia, Pa.) 2008;1(4):219-22.
2008: Heike Kroeger; Jaroslav Jelinek; Marcos R H Estécio; Rong He; Kimie Kondo; Woonbok Chung; LI Zhang; Lanlan Shen; Hagop M Kantarjian; Carlos E Bueso-Ramos; Jean-Pierre J Issa
Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse.
Blood 2008;112(4):1366-73.
2008: S-Q Kuang; W-G Tong; Huiling Yang; W Lin; M K Lee; Z H Fang; Yongkun Wei; Jaroslav Jelinek; Jean-Pierre J Issa; Guillermo Garcia-Manero
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia.
Leukemia 2008;22(8):1529-38.
2008: Tadeusz Majewski; Sangkyou Lee; Joon Jeong; Dong-Sup Yoon; Andrzej Kram; Mi-Sook Kim; Tomasz Tuziak; Jolanta Bondaruk; Sooyong Lee; Weon-Seo Park; Kuang S Tang; Woonbok Chung; Lanlan Shen; Saira S Ahmed; Dennis A Johnston; H Barton Grossman; Colin P Dinney; Jain-Hua Zhou; Ronald Harris; Carrie Snyder; Slawomir Filipek; steven narod; Patrice Watson; Henry T Lynch; Adi Gazdar; Menashe Bar-Eli; Xifeng F Wu; David J McConkey; Keith Baggerly; Jean-Pierre J Issa; William F Benedict; Steven E Scherer; Bogdan Czerniak
Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy.
Laboratory investigation; a journal of technical methods and pathology 2008;88(7):694-721.
2008: Yutaka Kondo; Lanlan Shen; Alfred S Cheng; Saira Ahmed; Yanis Boumber; Chantal Charo; Tadanori Yamochi; Takeshi Urano; Koichi Furukawa; Bernard Kwabi-Addo; David L Gold; Yoshitaka Sekido; Hui-Ming (Tim) Huang; Jean-Pierre J Issa
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation.
Nature genetics 2008;40(6):741-50.
2008: Elias Jabbour; Jean-Pierre J Issa; Guillermo Garcia-Manero; Andrew Lamb
Evolution of decitabine development: accomplishments, ongoing investigations, and future strategies.
Cancer 2008;112(11):2341-51.
2008: Xiangsheng Zuo; Lanlan Shen; Jean-Pierre J Issa; Ofir Moy; Jeffrey S Morris; Scott M Lippman; Imad Shureiqi
15-Lipoxygenase-1 transcriptional silencing by DNA methyltransferase-1 independently of DNA methylation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(6):1981-92.
2008: Eung Seok Lee; Jean-Pierre J Issa; Dianna B Roberts; Michelle D Williams; Randal S Weber; Merrill S Kies; Adel K El-Naggar
Quantitative promoter hypermethylation analysis of cancer-related genes in salivary gland carcinomas: comparison with methylation-specific PCR technique and clinical significance.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2664-72.
2008: Yutaka Suehiro; Chi Wai Wong; Lucian R Chirieac; Yutaka Kondo; Lanlan Shen; C Renee Webb; Yee Wai Chan; Annie S Y Chan; Tsun Leung Chan; Tsung-Teh Wu; Asif Rashid; Yuichiro Hamanaka; Yuji Hinoda; Rhonda L Shannon; Xuemei Wang; Jeffrey Morris; Jean-Pierre J Issa; Siu Tsan Yuen; Suet Yi Leung; Stanley R Hamilton
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(9):2560-9.
2008: Gautam Borthakur; Samih El Ahdab; Farhad Ravandi; Stefan Faderl; Alessandra Ferrajoli; Beth Newman; Jean-Pierre J Issa; Andrew Lamb
Activity of decitabine in patients with myelodysplastic syndrome previously treated with azacitidine.
Leukemia & lymphoma 2008;49(4):690-5.
2008: Weiwei Feng; Rebecca T Marquez; Zhen Lu; Jinsong Liu; Karen H Lu; Jean-Pierre J Issa; David M Fishman; Yinhua Yu; Robert C Bast
Imprinted tumor suppressor genes ARHI and PEG3 are the most frequently down-regulated in human ovarian cancers by loss of heterozygosity and promoter methylation.
Cancer 2008;112(7):1489-502.
2008: Yasuhiro Oki; Jaroslav Jelinek; Lanlan Shen; Hagop M Kantarjian; Jean-Pierre J Issa
Induction of hypomethylation and molecular response after decitabine therapy in patients with chronic myelomonocytic leukemia.
Blood 2008;111(4):2382-4.
2008: Marcos R H Estécio; Pearlly S Yan; Hui-Ming (Tim) Huang; Jean-Pierre J Issa
Methylated CpG Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation.
CSH protocols 2008;2008():pdb.prot4974.
2008: Yanis A Boumber; Yutaka Kondo; Xuqi Chen; Lanlan Shen; Yi Guo; Carmen Tellez; Marcos R H Estécio; Saira Ahmed; Jean-Pierre J Issa
An Sp1/Sp3 binding polymorphism confers methylation protection.
PLoS genetics 2008;4(8):e1000162.
2008: Woonbok Chung; Bernard Kwabi-Addo; Michael Ittmann; Jaroslav Jelinek; Lanlan Shen; Yinhua Yu; Jean-Pierre J Issa
Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling.
PloS one 2008;3(4):e2079.
2008: Yutaka Kondo; Lanlan Shen; Saira Ahmed; Yanis Boumber; Yoshitaka Sekido; Bassem R Haddad; Jean-Pierre J Issa
Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.
PloS one 2008;3(4):e2037.
2007: Yoko Tabe; Marina Konopleva; Yutaka Kondo; Rooha Contractor; Twee Tsao; Sergej Konoplev; Yuexi Shi; Xiaoyang Ling; Julie C Watt; Yuko Tsutsumi-Ishii; Akimichi Ohsaka; Isao Nagaoka; Jean-Pierre J Issa; Scott C Kogan; Michael Andreeff
PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.
Cancer biology & therapy 2007;6(12):1967-77.
2007: Lanlan Shen; Yutaka Kondo; Saira Ahmed; Yanis Boumber; Kazuo Konishi; Yi Guo; Xinli Chen; Jill N Vilaythong; Jean-Pierre J Issa
Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel.
Cancer research 2007;67(23):11335-43.
2007: Lanlan Shen; Minoru Toyota; Yutaka Kondo; E Lin; LI Zhang; Yi Guo; Natalie Supunpong Hernandez; Xinli Chen; Saira Ahmed; Kazuo Konishi; Stanley R Hamilton; Jean-Pierre J Issa
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(47):18654-9.
2007: Jie Wang; Manisha Bhutani; Ashutosh K Pathak; Wenhua Lang; Hening Ren; Jaroslav Jelinek; Rong He; Lanlan Shen; Jean-Pierre J Issa; Li Mao
Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.
Cancer research 2007;67(22):10647-52.
2007: Yasuhiro Oki; Jean-Pierre J Issa
Treatment options in advanced myelodysplastic syndrome, with emphasis on epigenetic therapy.
International journal of hematology 2007;86(4):306-14.
2007: Jaroslav Jelinek; Jun Li; Zakar Mnjoyan; Jean-Pierre J Issa; Josef T Prchal; Vahid Afshar-Kharghan
Epigenetic control of PRV-1 expression on neutrophils.
Experimental hematology 2007;35(11):1677-83.
2007: Yutaka Kondo; Lanlan Shen; Seiji Suzuki; Tsuyoshi Kurokawa; Kazuo Masuko; Yasuhito Tanaka; Hideaki Kato; Yoshiki Mizuno; Masamichi Yokoe; Fuminaka Sugauchi; Noboru Hirashima; Etsuro Orito; Hirotaka Osada; Ryuzo Ueda; Yi Guo; Xinli Chen; Jean-Pierre J Issa; Yoshitaka Sekido
Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.
Hepatology research : the official journal of the Japan Society of Hepatology 2007;37(11):974-83.
2007: Lanlan Shen; Paul J Catalano; Al B Benson; Peter O'Dwyer; Stanley R Hamilton; Jean-Pierre J Issa
Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(20):6093-8.
2007: Elizabeth R Plimack; David J Stewart; Jean-Pierre J Issa
Combining epigenetic and cytotoxic therapy in the treatment of solid tumors.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(29):4519-21.
2007: Lanlan Shen; Yutaka Kondo; Yi Guo; Jiexin Zhang; LI Zhang; Saira Ahmed; Jingmin Shu; Xinli Chen; Robert A Waterland; Jean-Pierre J Issa
Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters.
PLoS genetics 2007;3(10):2023-36.
2007: Marcos R H Estécio; Pearlly S Yan; Ashraf E K Ibrahim; Carmen Tellez; Lanlan Shen; Hui-Ming (Tim) Huang; Jean-Pierre J Issa
High-throughput methylation profiling by MCA coupled to CpG island microarray.
Genome research 2007;17(10):1529-36.
2007: Andres O Soriano; Hui Yang; Stefan Faderl; Zeev Estrov; Francis Giles; Farhad Ravandi; Jorge Cortes; William G Wierda; Souzanne Ouzounian; Andres Quezada; Sherry Pierce; Elihu H Estey; Jean-Pierre J Issa; Hagop M Kantarjian; Guillermo Garcia-Manero
Safety and clinical activity of the combination of 5-azacytidine, valproic acid, and all-trans retinoic acid in acute myeloid leukemia and myelodysplastic syndrome.
Blood 2007;110(7):2302-8.
2007: Si Ho Choi; Hyang-Min Byun; Jennifer M Kwan; Jean-Pierre J Issa; Allen S Yang
Hydroxycarbamide in combination with azacitidine or decitabine is antagonistic on DNA methylation inhibition.
British journal of haematology 2007;138(5):616-23.
2007: Sangkyou Lee; Joon Jeong; Tadeusz Majewski; Steven E Scherer; Mi-Sook Kim; Tomasz Tuziak; Kuang S Tang; Keith A Baggerly; H Barton Grossman; Jain-Hua Zhou; Lanlan Shen; Jolanta Bondaruk; Saira S Ahmed; Susmita Samanta; Philippe E Spiess; Xifeng Wu; Slawomir Filipek; David J McConkey; Menashe Bar-Eli; Jean-Pierre J Issa; William F Benedict; Bogdan Czerniak
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(34):13732-7.
2007: Elizabeth R Plimack; Hagop M Kantarjian; Jean-Pierre J Issa
Decitabine and its role in the treatment of hematopoietic malignancies.
Leukemia & lymphoma 2007;48(8):1472-81.
2007: Masamitsu Yanada; Xuelin Huang; Guillermo Garcia-Manero; Susan O'Brien; Farhad Ravandi; Gautam Borthakur; Stefan Faderl; Jean-Pierre J Issa; Andrew Lamb; Elihu Estey
Effect of haematological improvement on survival in patients given targeted therapy as initial treatment of acute myeloid leukaemia or high-risk myelodysplastic syndrome.
British journal of haematology 2007;138(4):555-7.
2007: Taichun Qin; Emile M Youssef; Jaroslav Jelinek; Rong Chen; Allen S Yang; Guillermo Garcia-Manero; Jean-Pierre J Issa
Effect of cytarabine and decitabine in combination in human leukemic cell lines.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4225-32.
2007: Bernard Kwabi-Addo; Woonbok Chung; Lanlan Shen; Michael Ittmann; Thomas Wheeler; Jaroslav Jelinek; Jean-Pierre J Issa
Age-related DNA methylation changes in normal human prostate tissues.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(13):3796-802.
2007: In-Seon Choi; Marcos R H Estecio; Yasuhiko Nagano; Do Ha Kim; Jill A White; James C Yao; Jean-Pierre J Issa; Asif Rashid
Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors).
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007;20(7):802-10.
2007: Xuelin Huang; Swati Biswas; Yasuhiro Oki; Jean-Pierre J Issa; Donald A Berry
A parallel phase I/II clinical trial design for combination therapies.
Biometrics 2007;63(2):429-36.
2007: Stéphane Temam; Hidetoshi Kawaguchi; Adel K El-Naggar; Jaroslav Jelinek; Hongli Tang; Diane D Liu; Wenhua Lang; Jean-Pierre J Issa; J Jack Lee; Li Mao
Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(16):2164-70.
2007: Kazuo Konishi; Lanlan Shen; Suna Wang; Meltzer Stephen J.; Noam Harpaz; Jean-Pierre J Issa
Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias.
Gastroenterology 2007;132(4):1254-60.
2007: Jean-Pierre J Issa
DNA methylation as a therapeutic target in cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(6):1634-7.
2007: Hagop M Kantarjian; Susan O'Brien; Xuelin Huang; Guillermo Garcia-Manero; Farhad Ravandi; Jorge Cortes; Jianqin Shan; Jan Davisson; Carlos E Bueso-Ramos; Jean-Pierre J Issa
Survival advantage with decitabine versus intensive chemotherapy in patients with higher risk myelodysplastic syndrome: comparison with historical experience.
Cancer 2007;109(6):1133-7.
2007: Jaroslav Jelinek; Jean-Pierre J Issa; Rong He; Radek Cmejla; Jana Cmejlova; Dagmar Pospisilova
RPS19 and JAK2 genes are not silenced by DNA methylation in diamond blackfan anemia.
Journal of pediatric hematology/oncology 2007;29(3):207-8.
2007: Yanis A Boumber; Yutaka Kondo; Xuqi Chen; Lanlan Shen; Vazganush Gharibyan; Kazuo Konishi; Elihu Estey; Andrew Lamb; Guillermo Garcia-Manero; Jean-Pierre J Issa
RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis.
Cancer research 2007;67(5):1997-2005.
2007: Yasuhiro Oki; Hagop M Kantarjian; Vazganush Gharibyan; Dan Jones; Susan O'Brien; Srdan Verstovsek; Jorge Cortes; Gail M Morris; Guillermo Garcia-Manero; Jean-Pierre J Issa
Phase II study of low-dose decitabine in combination with imatinib mesylate in patients with accelerated or myeloid blastic phase of chronic myelogenous leukemia.
Cancer 2007;109(5):899-906.
2007: Yasuhiro Oki; Etsuko Aoki; Jean-Pierre J Issa
Decitabine--bedside to bench.
Critical reviews in oncology/hematology 2007;61(2):140-52.
2007: Hagop M Kantarjian; Susan O'Brien; Jianqin Shan; Ahmed Aribi; Guillermo Garcia-Manero; Elias Jabbour; Farhad Ravandi; Jorge Cortes; Jan Davisson; Jean-Pierre J Issa
Update of the decitabine experience in higher risk myelodysplastic syndrome and analysis of prognostic factors associated with outcome.
Cancer 2007;109(2):265-73.
2007: Weiwei Feng; Lanlan Shen; Sijin Wen; Daniel G Rosen; Jaroslav Jelinek; Xin Hu; Shaoyi Huan; Miao Huang; Jinsong Liu; Aysegul A Sahin; Kelly K Hunt; Robert C Bast; Yu Shen; Jean-Pierre J Issa; Yinhua Yu
Correlation between CpG methylation profiles and hormone receptor status in breast cancers.
Breast cancer research : BCR 2007;9(4):R57.
2007: Marcos R H Estécio; Vazganush Gharibyan; Lanlan Shen; Ashraf E K Ibrahim; Ketan Doshi; Rong He; Jaroslav Jelinek; Allen S Yang; Pearlly S Yan; Hui-Ming (Tim) Huang; Eloiza H Tajara; Jean-Pierre J Issa
LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability.
PloS one 2007;2(5):e399.
2007: Kazuo Konishi; Jean-Pierre J Issa
Targeting aberrant chromatin structure in colorectal carcinomas.
Cancer journal (Sudbury, Mass.) 2007;13(1):49-55.
2007: Lanlan Shen; Yi Guo; Xinli Chen; Saira Ahmed; Jean-Pierre J Issa
Optimizing annealing temperature overcomes bias in bisulfite PCR methylation analysis.
BioTechniques 2007;42(1):48, 50, 52 passim.
2007: Ting Xi Liu; Michael W Becker; Jaroslav Jelinek; Wen-Shu Wu; Min Deng; Natallia Mikhalkevich; Karl Hsu; Clara D Bloomfield; Richard M Stone; Daniel J DeAngelo; Ilene Galinsky; Jean-Pierre J Issa; Michael F Clarke; A Thomas Look
Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation.
Nature medicine 2007;13(1):78-83.
2007: Jei Kim; Jee Yeon Kim; Kyu Sang Song; Young Ho Lee; Joong Seok Seo; Jaroslav Jelinek; Pascal J Goldschmidt-Clermont; Jean-Pierre J Issa
Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence.
Biochimica et biophysica acta 2007;1772(1):72-80.
2007: Andrew Lamb; Yasuhiro Oki; Guillermo Garcia-Manero; Xuelin Huang; Susan O'Brien; Jorge Cortes; Stefan Faderl; Carlos E Bueso-Ramos; Farhad Ravandi; Zeev Estrov; Alessandra Ferrajoli; William Wierda; Jianqin Shan; Jan Davis; Francis Giles; Hussain I Saba; Jean-Pierre J Issa
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia.
Blood 2007;109(1):52-7.
2006: Guillermo Garcia-Manero; Hagop M Kantarjian; Blanca Sanchez-Gonzalez; Hui Yang; Gary Rosner; Srdan Verstovsek; Michael Rytting; William G Wierda; Farhad Ravandi; Charles Koller; Lianchun Xiao; Stefan Faderl; Zeev Estrov; Jorge Cortes; Susan O'Brien; Elihu Estey; Carlos E Bueso-Ramos; Jackie Fiorentino; Elias Jabbour; Jean-Pierre J Issa
Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia.
Blood 2006;108(10):3271-9.
2006: Alberto Montero; C Marcela Díaz-Montero; Li Mao; Emile M Youssef; Marcos R H Estecio; Lanlan Shen; Jean-Pierre J Issa
Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer.
Cancer biology & therapy 2006;5(11):1494-501.
2006: Yoko Tabe; Marina Konopleva; Yutaka Kondo; Rooha Contractor; Linhua Jin; Vivian Ruvolo; Yuko Tsutsumi-Ishii; Kazunori Miyake; Noriko Miyake; Akimichi Ohsaka; Isao Nagaoka; Jean-Pierre J Issa; Michael Andreeff
PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter.
Annals of hematology 2006;85(10):689-704.
2006: Marcos R H Estécio; E M Youssef; Paula Rahal; Erica E Fukuyama; J F Góis-Filho; J V Maniglia; Eny Maria Goloni-Bertollo; Jean-Pierre J Issa; Eloiza H Tajara
LHX6 is a sensitive methylation marker in head and neck carcinomas.
Oncogene 2006;25(36):5018-26.
2006: Jared A Gollob; Catherine J Sciambi; Bercedis L Peterson; Tina Richmond; Monica Thoreson; Kelly Moran; Holly K Dressman; Jaroslav Jelinek; Jean-Pierre J Issa
Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(15):4619-27.
2006: Yasuhiro Oki; Jaroslav Jelinek; Miloslav Beran; Srdan Verstovsek; Hagop M Kantarjian; Jean-Pierre J Issa
Mutations and promoter methylation status of NPM1 in myeloproliferative disorders.
Haematologica 2006;91(8):1147-8.
2006: Allen S Yang; Ketan Doshi; Sang-Woon Choi; Joel B Mason; Rajan K Mannari; Vazganush Gharybian; Rene Luna; Asif Rashid; Lanlan Shen; Marcos R H Estecio; Hagop M Kantarjian; Guillermo Garcia-Manero; Jean-Pierre J Issa
DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia.
Cancer research 2006;66(10):5495-503.
2006: Jingmin Shu; Jaroslav Jelinek; Hao Chang; Lanlan Shen; Taichun Qin; Woonbok Chung; Yasuhiro Oki; Jean-Pierre J Issa
Silencing of bidirectional promoters by DNA methylation in tumorigenesis.
Cancer research 2006;66(10):5077-84.
2006: Yasuhiro Oki; Jean-Pierre J Issa
Review: recent clinical trials in epigenetic therapy.
Reviews on recent clinical trials 2006;1(2):169-82.
2006: Andrew Lamb; Jean-Pierre J Issa; Craig S Rosenfeld; John M Bennett; Maher Albitar; John DiPersio; Virginia Klimek; James Slack; Carlos de Castro; Farhad Ravandi; Richard Helmer; Lanlan Shen; Stephen D Nimer; Richard Leavitt; Azra Raza; Hussain I Saba
Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study.
Cancer 2006;106(8):1794-803.
2006: Yinhua Yu; Robert Luo; Zhen Lu; Wei Wei Feng; Donna Badgwell; Jean-Pierre J Issa; Daniel G Rosen; Jinsong Liu; Robert C Bast
Biochemistry and biology of ARHI (DIRAS3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers.
Methods in enzymology 2006;407():455-68.
2005: Jean-Pierre J Issa
Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection.
Nature clinical practice. Oncology 2005;2 Suppl 1():S24-9.
2005: Annie On-On Chan; Amr S Soliman; Qing Zhang; Asif Rashid; Ahmed Bedeir; Patrick S Houlihan; Nadia Mokhtar; Nidal Al-Masri; Ugur Ozbek; Rami J Yaghan; Ayten Kandilci; Sherif Omar; Yersu Kapran; Ferhunde Dizdaroglu; Melissa L Bondy; Christopher I Amos; Jean-Pierre J Issa; Bernard Levin; Stanley R Hamilton
Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(23):8281-7.
2005: Jaroslav Jelinek; Yasuhiro Oki; Vazganush Gharibyan; Carlos E Bueso-Ramos; Josef T Prchal; Srdan Verstovsek; Miloslav Beran; Elihu Estey; Hagop M Kantarjian; Jean-Pierre J Issa
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
Blood 2005;106(10):3370-3.
2005: Minoru Toyota; Jean-Pierre J Issa
Epigenetic changes in solid and hematopoietic tumors.
Seminars in oncology 2005;32(5):521-30.
2005: Lanlan Shen; Yutaka Kondo; Gary Rosner; Lianchun Xiao; Natalie Supunpong Hernandez; Jill Vilaythong; Patrick S Houlihan; Robert S Krouse; AR Prasad; Janine G Einspahr; Julie Buckmeier; David S Alberts; Stanley R Hamilton; Jean-Pierre J Issa
MGMT promoter methylation and field defect in sporadic colorectal cancer.
Journal of the National Cancer Institute 2005;97(18):1330-8.
2005: Jean-Pierre J Issa
DNA methylation in the treatment of hematologic malignancies.
Clinical advances in hematology & oncology : H&O 2005;3(9):684-6.
2005: Jean-Pierre J Issa; Lanlan Shen; Minoru Toyota
CIMP, at last.
Gastroenterology 2005;129(3):1121-4.
2005: Andreia A Canalli; Hui Yang; Sima Jeha; Koyu Hoshino; Blanca Sanchez-Gonzalez; Mark Brandt; Sherry Pierce; Andrew Lamb; Jean-Pierre J Issa; Guillermo Garcia-Manero
Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia.
Leukemia research 2005;29(8):881-5.
2005: Jean-Pierre J Issa; John C Byrd
Decitabine in chronic leukemias.
Seminars in hematology 2005;42(3 Suppl 2):S43-9.
2005: Hagop M Kantarjian; Jean-Pierre J Issa
Decitabine dosing schedules.
Seminars in hematology 2005;42(3 Suppl 2):S17-22.
2005: Jean-Pierre J Issa; Hagop M Kantarjian
Introduction: emerging role of epigenetic therapy: focus on decitabine.
Seminars in hematology 2005;42(3 Suppl 2):S1-2.
2005: Kimishige Akino; Minoru Toyota; Hiromu Suzuki; Hiroaki Mita; Yasushi Sasaki; Mutsumi Ohe-Toyota; Jean-Pierre J Issa; Yuji Hinoda; Kohzoh Imai; Takashi Tokino
The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancer.
Gastroenterology 2005;129(1):156-69.
2005: Jean-Pierre J Issa; Vazganush Gharibyan; Jorge Cortes; Jaroslav Jelinek; Gail Morris; Srdan Verstovsek; Moshe Talpaz; Guillermo Garcia-Manero; Hagop M Kantarjian
Phase II study of low-dose decitabine in patients with chronic myelogenous leukemia resistant to imatinib mesylate.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(17):3948-56.
2005: Jean-Pierre J Issa; Andrew Lamb
Azacitidine.
Nature reviews. Drug discovery 2005;Suppl():S6-7.
2005: Jean-Pierre J Issa; Hagop M Kantarjian; Peter Kirkpatrick
Azacitidine.
Nature reviews. Drug discovery 2005;4(4):275-6.
2005: Robyn Beach; Annie On-On Chan; Tsung-Teh Wu; Jill A White; Jeffrey S Morris; Simon Lunagomez; Russell R Broaddus; Jean-Pierre J Issa; Stanley R Hamilton; Asif Rashid
BRAF mutations in aberrant crypt foci and hyperplastic polyposis.
The American journal of pathology 2005;166(4):1069-75.
2005: Lucian R Chirieac; Lanlan Shen; Paul J Catalano; Jean-Pierre J Issa; Stanley R Hamilton
Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation.
The American journal of surgical pathology 2005;29(4):429-36.
2005: Masafumi Murai; Minoru Toyota; Ayumi Satoh; Hiromu Suzuki; Kimishige Akino; Hiroaki Mita; Yasushi Sasaki; T Ishida; L Shen; G Garcia-Manero; Jean-Pierre J Issa; Yuji Hinoda; Takashi Tokino; Kohzoh Imai
Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.
British journal of cancer 2005;92(6):1165-72.
2005: Guillermo Garcia-Manero; Jean-Pierre J Issa
Histone deacetylase inhibitors: a review of their clinical status as antineoplastic agents.
Cancer investigation 2005;23(7):635-42.
2004: Jean-Pierre J Issa
CpG island methylator phenotype in cancer.
Nature reviews. Cancer 2004;4(12):988-93.
2004: Asif Rashid; Jean-Pierre J Issa
CpG island methylation in gastroenterologic neoplasia: a maturing field.
Gastroenterology 2004;127(5):1578-88.
2004: Emile M Youssef; Jean-Pierre J Issa; Reuben Lotan
Regulation of RARbeta1 expression in head and neck cancer cells by cell density-dependent chromatin remodeling.
Cancer biology & therapy 2004;3(10):1002-6.
2004: Shin-ichiro Maruya; Jean-Pierre J Issa; Randal S Weber; David I Rosenthal; Joie C Haviland; Reuben Lotan; Adel K El-Naggar
Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(11):3825-30.
2004: Yutaka Kondo; Lanlan Shen; Pearlly S Yan; Hui-Ming (Tim) Huang; Jean-Pierre J Issa
Chromatin immunoprecipitation microarrays for identification of genes silenced by histone H3 lysine 9 methylation.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(19):7398-403.
2004: Emile M Youssef; Xu-qi Chen; Eisaku Higuchi; Yutaka Kondo; Guillermo Garcia-Manero; Reuben Lotan; Jean-Pierre J Issa
Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers.
Cancer research 2004;64(7):2411-7.
2004: Emile M Youssef; Dafna Lotan; Jean-Pierre J Issa; Kenichi Wakasa; You-Hong Fan; Li Mao; Khaled Aref Hassan; Lei Feng; J Jack Lee; Scott M Lippman; Waun Ki Hong; Reuben Lotan
Hypermethylation of the retinoic acid receptor-beta(2) gene in head and neck carcinogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(5):1733-42.
2004: Jean-Pierre J Issa; Guillermo Garcia-Manero; Francis Giles; Rajan Mannari; Deborah Thomas; Stefan Faderl; Emel Bayar; John Lyons; Craig S Rosenfeld; Jorge Cortes; Hagop M Kantarjian
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies.
Blood 2004;103(5):1635-40.
2004: Alan F List; James Vardiman; Jean-Pierre J Issa; Theo M DeWitte
Myelodysplastic syndromes.
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program 2004;():297-317.
2004: Yutaka Kondo; Jean-Pierre J Issa
Epigenetic changes in colorectal cancer.
Cancer metastasis reviews 2004;23(1-2):29-39.
2004: Allen S Yang; Marcos R H Estécio; Ketan Doshi; Yutaka Kondo; Eloiza H Tajara; Jean-Pierre J Issa
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements.
Nucleic acids research 2004;32(3):e38.
2004: Emile M Youssef; Marcos R H Estecio; Jean-Pierre J Issa
Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer.
Cancer biology & therapy 2004;3(1):82-6.
2003: Toshiro Obata; Minoru Toyota; Ayumi Satoh; Yasushi Sasaki; Kazuhiro Ogi; Kimishige Akino; Hiromu Suzuki; Masafumi Murai; Takefumi Kikuchi; Hiroaki Mita; Fumio Itoh; Jean-Pierre J Issa; Takashi Tokino; Kohzoh Imai
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(17):6410-8.
2003: Allen S Yang; Marcos R H Estecio; Guillermo Garcia-Manero; Hagop M Kantarjian; Jean-Pierre J Issa
Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation".
Science (New York, N.Y.) 2003;302(5648):1153; author reply 1153.
2003: Jean-Pierre J Issa
Decitabine.
Current opinion in oncology 2003;15(6):446-51.
2003: KIM SANG GEOL; Tsung-Teh Wu; Jae Hyuk Lee; Young Kook Yun; Jean-Pierre J Issa; Stanley R Hamilton; Asif Rashid
Comparison of epigenetic and genetic alterations in mucinous cystic neoplasm and serous microcystic adenoma of pancreas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2003;16(11):1086-94.
2003: Steven A Belinsky; Donna M Klinge; Christine A Stidley; Jean-Pierre J Issa; James G Herman; Thomas H March; Stephen B Baylin
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Cancer research 2003;63(21):7089-93.
2003: Jean-Pierre J Issa
Age-related epigenetic changes and the immune system.
Clinical immunology (Orlando, Fla.) 2003;109(1):103-8.
2003: Luciane Cavalli; Cicero Urban; Dongqiu Dai; Sônia de Assis; Denise C Tavares; Janice D Rone; Luiz F Bleggi-Torres; Rubens S Lima; Iglenir J Cavalli; Jean-Pierre J Issa; Bassem R Haddad
Genetic and epigenetic alterations in sentinel lymph nodes metastatic lesions compared to their corresponding primary breast tumors.
Cancer genetics and cytogenetics 2003;146(1):33-40.
2003: Marsha L Frazier; Lixuan Xi; Jihong Zong; Nancy Viscofsky; Asif Rashid; Elsie F Wu; Patrick M Lynch; Christopher I Amos; Jean-Pierre J Issa
Association of the CpG island methylator phenotype with family history of cancer in patients with colorectal cancer.
Cancer research 2003;63(16):4805-8.
2003: Jean-Pierre J Issa
Methylation and prognosis: of molecular clocks and hypermethylator phenotypes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(8):2879-81.
2003: Hagop M Kantarjian; Susan O'Brien; Jorge Cortes; Francis Giles; Stefan Faderl; Jean-Pierre J Issa; Guillermo Garcia-Manero; Mary Beth Rios; Jianqin Shan; Michael Andreeff; Michael Keating; Moshe Talpaz
Results of decitabine (5-aza-2'deoxycytidine) therapy in 130 patients with chronic myelogenous leukemia.
Cancer 2003;98(3):522-8.
2003: Satoshi Fujii; Robert Z Luo; Jiuhong Yuan; Mitsutaka Kadota; Mitsuo Oshimura; Sharon R Dent; Yutaka Kondo; Jean-Pierre J Issa; Robert C Bast; Yinhua Yu
Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.
Human molecular genetics 2003;12(15):1791-800.
2003: Yutaka Kondo; Jean-Pierre J Issa
Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells.
The Journal of biological chemistry 2003;278(30):27658-62.
2003: Jiuhong Yuan; Robert Z Luo; Satoshi Fujii; Lin Wang; Wei Hu; Michael Andreeff; Yong Pan; Mitsutaka Kadota; Mitsuo Oshimura; Aysegul A Sahin; Jean-Pierre J Issa; Robert C Bast; Yinhua Yu
Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers.
Cancer research 2003;63(14):4174-80.
2003: Hui Li; Lois Myeroff; Dominic J Smiraglia; Michael F Romero; Theresa P Pretlow; Lakshmi Kasturi; James Lutterbaugh; Ronald M Rerko; Graham Casey; Jean-Pierre J Issa; Joseph Willis; James Willson; Christoph Plass; Sanford D Markowitz
SLC5A8, a sodium transporter, is a tumor suppressor gene silenced by methylation in human colon aberrant crypt foci and cancers.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(14):8412-7.
2003: Stefano Colella; Lanlan Shen; Keith A Baggerly; Jean-Pierre J Issa; Ralf Krahe
Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites.
BioTechniques 2003;35(1):146-50.
2003: Minoru Toyota; Yasushi Sasaki; Ayumi Satoh; Kazuhiro Ogi; Takefumi Kikuchi; Hiromu Suzuki; Hiroaki Mita; Nobuyuki Tanaka; Fumio Itoh; Jean-Pierre J Issa; Kam-Wing Jair; Kornel E Schuebel; Kohzoh Imai; Takashi Tokino
Epigenetic inactivation of CHFR in human tumors.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(13):7818-23.
2003: LanLan Shen; Minoru Toyota; Yutaka Kondo; Toshiro Obata; Sophia Daniel; Sherry Pierce; Kohzoh Imai; Hagop M Kantarjian; Jean-Pierre J Issa; Guillermo Garcia-Manero
Aberrant DNA methylation of p57KIP2 identifies a cell-cycle regulatory pathway with prognostic impact in adult acute lymphocytic leukemia.
Blood 2003;101(10):4131-6.
2003: Allen S Yang; Jean-Pierre J Issa
Mitoxantrone: a hypomethylating agent?
Cancer biology & therapy 2003;2(3):264-5.
2003: KIM SANG GEOL; Annie On-On Chan; Tsung-Teh Wu; Jean-Pierre J Issa; Stanley R Hamilton; Asif Rashid
Epigenetic and genetic alterations in duodenal carcinomas are distinct from biliary and ampullary carcinomas.
Gastroenterology 2003;124(5):1300-10.
2003: Yinhua Yu; Satoshi Fujii; Jiuhong Yuan; Robert Z Luo; Lin Wang; Jiaju Bao; Mitsutaka Kadota; Mitsuo Oshimura; Sharon R Dent; Jean-Pierre J Issa; Robert C Bast
Epigenetic regulation of ARHI in breast and ovarian cancer cells.
Annals of the New York Academy of Sciences 2003;983():268-77.
2003: Lanlan Shen; Yutaka Kondo; Stanley R Hamilton; Asif Rashid; Jean-Pierre J Issa
P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53.
Gastroenterology 2003;124(3):626-33.
2003: Annie On-On Chan; KIM SANG GEOL; Ahmed Bedeir; Jean-Pierre J Issa; Stanley R Hamilton; Asif Rashid
CpG island methylation in carcinoid and pancreatic endocrine tumors.
Oncogene 2003;22(6):924-34.
2003: Guillermo Garcia-Manero; Sima Jeha; Jerry Daniel; Jason Williamson; Maher Albitar; Hagop M Kantarjian; Jean-Pierre J Issa
Aberrant DNA methylation in pediatric patients with acute lymphocytic leukemia.
Cancer 2003;97(3):695-702.
2003: Yutaka Kondo; LanLan Shen; Jean-Pierre J Issa
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.
Molecular and cellular biology 2003;23(1):206-15.
2002: LanLan Shen; Yutaka Kondo; Jean-Pierre J Issa; Guillermo Garcia-Manero
Lack of p21(CIP1) DNA methylation in acute lymphocytic leukemia.
Blood 2002;100(9):3432-3; author reply 3433-4.
2002: Jean-Pierre J Issa
Epigenetic variation and human disease.
The Journal of nutrition 2002;132(8 Suppl):2388S-2392S.
2002: Guillermo Garcia-Manero; Jerry Daniel; Terry L Smith; Steven M Kornblau; Ming-Sheng Lee; Hagop M Kantarjian; Jean-Pierre J Issa
DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2217-24.
2002: Hagop M Kantarjian; Moshe Talpaz; Susan O'Brien; Terry L Smith; Francis Giles; Stefan Faderl; Deborah A Thomas; Guillermo Garcia-Manero; Jean-Pierre J Issa; Michael Andreeff; Steven M Kornblau; Charles Koller; Miloslav Beran; Michael Keating; Mary Beth Rios; Jianqin Shan; Debra Resta; Renaud Capdeville; Kimberly Hayes; Maher Albitar; Emil J Freireich; Jorge E Cortes
Imatinib mesylate for Philadelphia chromosome-positive, chronic-phase myeloid leukemia after failure of interferon-alpha: follow-up results.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2177-87.
2002: Hagop M Kantarjian; Susan O'Brien; Jorge E Cortes; Terry L Smith; Mary Beth Rios; Jianqin Shan; Ying Yang; Francis Giles; Deborah A Thomas; Stefan Faderl; Guillermo Garcia-Manero; Sima Jeha; William G Wierda; Jean-Pierre J Issa; Steven M Kornblau; Michael Keating; Debra Resta; Renaud Capdeville; Moshe Talpaz
Treatment of philadelphia chromosome-positive, accelerated-phase chronic myelogenous leukemia with imatinib mesylate.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(7):2167-76.
2002: Guillermo Garcia-Manero; Carlos E Bueso-Ramos; Jerry Daniel; Jason Williamson; Hagop M Kantarjian; Jean-Pierre J Issa
DNA methylation patterns at relapse in adult acute lymphocytic leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(6):1897-903.
2002: Lanlan Shen; NITA AHUJA; Yu Shen; Nagy A Habib; Minoru Toyota; Asif Rashid; Jean-Pierre J Issa
DNA methylation and environmental exposures in human hepatocellular carcinoma.
Journal of the National Cancer Institute 2002;94(10):755-61.
2002: Jean-Charles Soria; Ho-Young Lee; Janet I Lee; Luo Wang; Jean-Pierre J Issa; Bonnie L Kemp; Diane D Liu; Jonathan M Kurie; Li Mao; Fadlo R Khuri
Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation.
Clinical cancer research : an official journal of the American Association for Cancer Research 2002;8(5):1178-84.
2002: Annie On-On Chan; Russell R Broaddus; Patrick S Houlihan; Jean-Pierre J Issa; Stanley R Hamilton; Asif Rashid
CpG island methylation in aberrant crypt foci of the colorectum.
The American journal of pathology 2002;160(5):1823-30.
2002: Takefumi Kikuchi; Minoru Toyota; Fumio Itoh; Hiromu Suzuki; Toshiro Obata; Hiroyuki Yamamoto; Hideki Kakiuchi; Masanobu Kusano; Jean-Pierre J Issa; Takashi Tokino; Kohzoh Imai
Inactivation of p57KIP2 by regional promoter hypermethylation and histone deacetylation in human tumors.
Oncogene 2002;21(17):2741-9.
2002: Helen R Moinova; Wei-Dong Chen; Lanlan Shen; Dominic J Smiraglia; Joseph Olechnowicz; Lakshmeswari Ravi; Lakshmi Kasturi; Lois Myeroff; Christoph Plass; Ramon Parsons; John D Minna; James Willson; Sylvan B Green; Jean-Pierre J Issa; Sanford D Markowitz
HLTF gene silencing in human colon cancer.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(7):4562-7.
2002: Annie On-On Chan; Jean-Pierre J Issa; Jeffrey S Morris; Stanley R Hamilton; Asif Rashid
Concordant CpG island methylation in hyperplastic polyposis.
The American journal of pathology 2002;160(2):529-36.
2002: Lanlan Shen; Jean-Pierre J Issa
Epigenetics in colorectal cancer.
Current opinion in gastroenterology 2002;18(1):68-73.
2002: Minoru Toyota; Jean-Pierre J Issa
Methylated CpG island amplification for methylation analysis and cloning differentially methylated sequences.
Methods in molecular biology (Clifton, N.J.) 2002;200():101-10.
2001: Takashi Ueki; M Toyota; Halcyon Skinner; Kimberly M Walter; Charles J Yeo; Jean-Pierre J Issa; Ralph Hruban; Michael Goggins
Identification and characterization of differentially methylated CpG islands in pancreatic carcinoma.
Cancer research 2001;61(23):8540-6.
2001: Garth R Anderson; B M Brenner; Helen Swede; Neng Chen; W M Henry; Jeffrey M Conroy; M J Karpenko; Jean-Pierre J Issa; Jeremy D Bartos; J K Brunelle; G P Jahreis; Morton Kahlenberg; M Basik; Sheila N J Sait; Miguel A Rodriguez-Bigas; Norma J Nowak; Nicholas J Petrelli; TB Shows; Daniel L Stoler
Intrachromosomal genomic instability in human sporadic colorectal cancer measured by genome-wide allelotyping and inter-(simple sequence repeat) PCR.
Cancer research 2001;61(22):8274-83.
2001: H Peng; N Shen; L Qian; X L Sun; Prasad R K Koduru; L O Goodwin; Jean-Pierre J Issa; JD Broome
Hypermethylation of CpG islands in the mouse asparagine synthetase gene: relationship to asparaginase sensitivity in lymphoma cells. Partial methylation in normal cells.
British journal of cancer 2001;85(6):930-5.
2001: Asif Rashid; Lanlan Shen; Jeffrey S Morris; Jean-Pierre J Issa; Stanley R Hamilton
CpG island methylation in colorectal adenomas.
The American journal of pathology 2001;159(3):1129-35.
2001: Robert Z Luo; Hua Peng; F Xu; J Bao; Y Pang; R Pershad; Jean-Pierre J Issa; Warren S-L Liao; Robert C Bast; Yinhua Yu
Genomic structure and promoter characterization of an imprinted tumor suppressor gene ARHI.
Biochimica et biophysica acta 2001;1519(3):216-22.
2001: Jean-Pierre J Issa; NITA AHUJA; M Toyota; Mary P Bronner; Teresa A Brentnall
Accelerated age-related CpG island methylation in ulcerative colitis.
Cancer research 2001;61(9):3573-7.
2001: M Toyota; K J Kopecky; M O Toyota; K W Jair; C L Willman; Jean-Pierre J Issa
Methylation profiling in acute myeloid leukemia.
Blood 2001;97(9):2823-9.
2001: Valeria Santini; H M Kantarjian; Jean-Pierre J Issa
Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications.
Annals of internal medicine 2001;134(7):573-86.
2000: M Toyota; L Shen; M Ohe-Toyota; Stanley R Hamilton; F A Sinicrope; Jean-Pierre J Issa
Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.
Cancer research 2000;60(15):4044-8.
2000: NITA AHUJA; Jean-Pierre J Issa
Aging, methylation and cancer.
Histology and histopathology 2000;15(3):835-42.
2000: Jean-Pierre J Issa
The epigenetics of colorectal cancer.
Annals of the New York Academy of Sciences 2000;910():140-53; discussion 153-5.
2000: Manel Esteller; M Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel A Peinado; DAVID WATKINS; Jean-Pierre J Issa; David Sidransky; Stephen B Baylin; James G Herman
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis.
Cancer research 2000;60(9):2368-71.
2000: Takashi Ueki; M Toyota; Taylor A Sohn; Charles J Yeo; Jean-Pierre J Issa; Ralph Hruban; Michael Goggins
Hypermethylation of multiple genes in pancreatic adenocarcinoma.
Cancer research 2000;60(7):1835-9.
2000: Minoru Toyota; M Ohe-Toyota; NITA AHUJA; Jean-Pierre J Issa
Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(2):710-5.
2000: Jean-Pierre J Issa
CpG-island methylation in aging and cancer.
Current topics in microbiology and immunology 2000;249():101-18.
2000: M Toyota; Jean-Pierre J Issa
The role of DNA hypermethylation in human neoplasia.
Electrophoresis 2000;21(2):329-33.
1999: Minoru Toyota; NITA AHUJA; H Suzuki; F Itoh; M Ohe-Toyota; K Imai; Stephen B Baylin; Jean-Pierre J Issa
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Cancer research 1999;59(21):5438-42.
1999: Minoru Toyota; Jean-Pierre J Issa
CpG island methylator phenotypes in aging and cancer.
Seminars in cancer biology 1999;9(5):349-57.
1999: Minoru Toyota; C Ho; M Ohe-Toyota; Stephen B Baylin; Jean-Pierre J Issa
Inactivation of CACNA1G, a T-type calcium channel gene, by aberrant methylation of its 5' CpG island in human tumors.
Cancer research 1999;59(18):4535-41.
1999: Wendy S Post; Pascal J Goldschmidt-Clermont; CC Wilhide; Alan Heldman; Marc S Sussman; Pamela Ouyang; Erin Milliken; Jean-Pierre J Issa
Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system.
Cardiovascular research 1999;43(4):985-91.
1999: Jean-Pierre J Issa
Aging, DNA methylation and cancer.
Critical reviews in oncology/hematology 1999;32(1):31-43.
1999: Minoru Toyota; NITA AHUJA; M Ohe-Toyota; James G Herman; Stephen B Baylin; Jean-Pierre J Issa
CpG island methylator phenotype in colorectal cancer.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(15):8681-6.
1999: Qing Li; NITA AHUJA; Peter C Burger; Jean-Pierre J Issa
Methylation and silencing of the Thrombospondin-1 promoter in human cancer.
Oncogene 1999;18(21):3284-9.
1999: Minoru Toyota; C Ho; NITA AHUJA; Kam-Wing Jair; Qing Li; M Ohe-Toyota; Stephen B Baylin; Jean-Pierre J Issa
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification.
Cancer research 1999;59(10):2307-12.
1999: Qing Li; K J Kopecky; A Mohan; C L Willman; F R Appelbaum; J K Weick; Jean-Pierre J Issa
Estrogen receptor methylation is associated with improved survival in adult acute myeloid leukemia.
Clinical cancer research : an official journal of the American Association for Cancer Research 1999;5(5):1077-84.
1999: Jean-Pierre J Issa; H Kantarjian; A Mohan; S O'Brien; J Cortes; S Pierce; Moshe Talpaz
Methylation of the ABL1 promoter in chronic myelogenous leukemia: lack of prognostic significance.
Blood 1999;93(6):2075-80.
1998: NITA AHUJA; Qing Li; A L Mohan; Stephen B Baylin; Jean-Pierre J Issa
Aging and DNA methylation in colorectal mucosa and cancer.
Cancer research 1998;58(23):5489-94.
1998: Judy A Mikovits; H A Young; Paula M Vertino; Jean-Pierre J Issa; PAULA PITHA-ROWE; S Turcoski-Corrales; Dennis D Taub; C L Petrow; Stephen B Baylin; Francis W Ruscetti
Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.
Molecular and cellular biology 1998;18(9):5166-77.
1998: Qing Li; Anne E Jedlicka; NITA AHUJA; M C Gibbons; Stephen B Baylin; Peter C Burger; Jean-Pierre J Issa
Concordant methylation of the ER and N33 genes in glioblastoma multiforme.
Oncogene 1998;16(24):3197-202.
1998: James G Herman; A Umar; Kornelia Polyak; Jeremy R Graff; NITA AHUJA; Jean-Pierre J Issa; Sanford Markowitz; James Willson; Stanley R Hamilton; Kenneth W Kinzler; Michael F Kane; Richard D Kolodner; Bert Vogelstein; T A Kunkel; Stephen B Baylin
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(12):6870-5.
1998: Christoph Lengauer; Jean-Pierre J Issa
The role of epigenetics in cancer. DNA Methylation, Imprinting and the Epigenetics of Cancer--an American Association for Cancer Research Special Conference. Las Croabas, Puerto Rico, 12-16 1997 December.
Molecular medicine today 1998;4(3):102-3.
1998: Stephen B Baylin; James G Herman; Jeremy R Graff; Paula M Vertino; Jean-Pierre J Issa
Alterations in DNA methylation: a fundamental aspect of neoplasia.
Advances in cancer research 1998;72():141-96.
1997: NITA AHUJA; A L Mohan; Qing Li; J M Stolker; James G Herman; Stanley R Hamilton; Stephen B Baylin; Jean-Pierre J Issa
Association between CpG island methylation and microsatellite instability in colorectal cancer.
Cancer research 1997;57(16):3370-4.
1997: Jean-Pierre J Issa; B A Zehnbauer; S H Kaufmann; M A Biel; Stephen B Baylin
HIC1 hypermethylation is a late event in hematopoietic neoplasms.
Cancer research 1997;57(9):1678-81.
1997: Jean-Pierre J Issa; Stephen B Baylin; James G Herman
DNA methylation changes in hematologic malignancies: biologic and clinical implications.
Leukemia 1997;11 Suppl 1():S7-11.
1997: James G Herman; Curt I Civin; Jean-Pierre J Issa; Michael I Collector; Saul J Sharkis; Stephen B Baylin
Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies.
Cancer research 1997;57(5):837-41.
1996: Jean-Pierre J Issa; Paula M Vertino; Corinne D Boehm; Irene Newsham; Stephen B Baylin
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(21):11757-62.
1996: Jean-Pierre J Issa; Stephen B Baylin; Steven A Belinsky
Methylation of the estrogen receptor CpG island in lung tumors is related to the specific type of carcinogen exposure.
Cancer research 1996;56(16):3655-8.
1996: Rena Lapidus; AT Ferguson; YVONNE OTTAVIANO; F F Parl; H S Smith; S A Weitzman; Stephen B Baylin; Jean-Pierre J Issa; Nancy E Davidson
Methylation of estrogen and progesterone receptor gene 5' CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 1996;2(5):805-10.
1996: Steven A Belinsky; Kristen J Nikula; Stephen B Baylin; Jean-Pierre J Issa
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(9):4045-50.
1996: Jean-Pierre J Issa; B A Zehnbauer; Curt I Civin; Michael I Collector; Saul J Sharkis; Nancy E Davidson; Scott H Kaufmann; Stephen B Baylin
The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.
Cancer research 1996;56(5):973-77.
1996: Jean-Pierre J Issa; Stephen B Baylin
Epigenetics and human disease.
Nature medicine 1996;2(3):281-2.
1995: Steven A Belinsky; Kristen J Nikula; Stephen B Baylin; Jean-Pierre J Issa
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression.
Toxicology letters 1995;82-83():335-40.
1995: James G Herman; A Merlo; Li Mao; Rena Lapidus; Jean-Pierre J Issa; Nancy E Davidson; David Sidransky; Stephen B Baylin
Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.
Cancer research 1995;55(20):4525-30.
1995: M M Wales; M A Biel; Wafik S El-Deiry; Barry D Nelkin; Jean-Pierre J Issa; W K Cavenee; S J Kuerbitz; Stephen B Baylin
p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3.
Nature medicine 1995;1(6):570-7.
1994: Paula M Vertino; Jean-Pierre J Issa; Olivia M Pereira-Smith; Stephen B Baylin
Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research 1994;5(12):1395-402.
1994: Jean-Pierre J Issa; YVONNE OTTAVIANO; P Celano; Stanley R Hamilton; Nancy E Davidson; Stephen B Baylin
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon.
Nature genetics 1994;7(4):536-40.
1994: YVONNE OTTAVIANO; Jean-Pierre J Issa; F F Parl; H S Smith; Stephen B Baylin; Nancy E Davidson
Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells.
Cancer research 1994;54(10):2552-5.
1993: J Wu; Jean-Pierre J Issa; James G Herman; D E Bassett; Barry D Nelkin; Stephen B Baylin
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Proceedings of the National Academy of Sciences of the United States of America 1993;90(19):8891-5.
1993: Jean-Pierre J Issa; Paula M Vertino; J Wu; Sunil Sazawal; P Celano; Barry D Nelkin; S R Hamilton; Stephen B Baylin
Increased cytosine DNA-methyltransferase activity during colon cancer progression.
Journal of the National Cancer Institute 1993;85(15):1235-40.