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Akiko Itai

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Tetsu Tanaka; Yasunobu Hirata; Akiko Itai; Ryozo Nagai; Masahito Ogawa; Asuka Sekinishi; Jun-Ichi Suzuki; Mitsuaki Isobe
Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice.
Rikuta Hamaya; Yasunobu Hirata; Akiko Itai; Naho Kobayashi; Ryozo Nagai; Masahito Ogawa; Jun-Ichi Suzuki; Mitsuaki Isobe
A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice.
Miho Y Mizutani; Yoshihiro Takamatsu; Tazuko Ichinose; Akiko Itai
Prediction of ligand binding affinity using a multiple-conformations-multiple-protonation scheme: application to estrogen receptor α.

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All Publications

2012: Tetsu Tanaka; Yasunobu Hirata; Akiko Itai; Ryozo Nagai; Masahito Ogawa; Asuka Sekinishi; Jun-Ichi Suzuki; Mitsuaki Isobe
Inhibition of IκB phosphorylation prevents load-induced cardiac dysfunction in mice.
American journal of physiology. Heart and circulatory physiology 2012;303(12):H1435-45.
2012: Rikuta Hamaya; Yasunobu Hirata; Akiko Itai; Naho Kobayashi; Ryozo Nagai; Masahito Ogawa; Jun-Ichi Suzuki; Mitsuaki Isobe
A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice.
International heart journal 2012;53(2):133-8.
2012: Miho Y Mizutani; Yoshihiro Takamatsu; Tazuko Ichinose; Akiko Itai
Prediction of ligand binding affinity using a multiple-conformations-multiple-protonation scheme: application to estrogen receptor α.
Chemical & pharmaceutical bulletin 2012;60(2):183-94.
2012: Shin Uota; Atae Utsunomiya; Toshiki Watanabe; Naoki Yamamoto; Akiko Itai; Susumu Muto; Yasunori Saitoh; Md Zahidunnabi Dewan; Shoji Yamaoka
An IκB kinase 2 inhibitor IMD-0354 suppresses the survival of adult T-cell leukemia cells.
Cancer science 2012;103(1):100-6.
2011: Jun-ichi Suzuki; Masahito Ogawa; Susumu Muto; Akiko Itai; Mitsuaki Isobe; Yasunobu Hirata; Ryozo Nagai
Novel IkB kinase inhibitors for treatment of nuclear factor-kB-related diseases.
Expert opinion on investigational drugs 2011;20(3):395-405.
2011: Jun-Ichi Suzuki; Masahito Ogawa; Susumu Muto; Akiko Itai; Yasunobu Hirata; Mitsuaki Isobe; Ryozo Nagai
Effects of specific chemical suppressors of plasminogen activator inhibitor-1 in cardiovascular diseases.
Expert opinion on investigational drugs 2011;20(2):255-64.
2011: Masahito Ogawa; Jun-ichi Suzuki; Yoichi Yamaguchi; Susumu Muto; Akiko Itai; Yasunobu Hirata; Mitsuaki Isobe; Ryozo Nagai
The effects of pharmacologic plasminogen activator inhibitor-1 inhibition in acute and chronic rejection in murine cardiac allografts.
Transplantation 2011;91(1):21-6.
2009: Yoku Hayakawa; Shin Maeda; Hayato Nakagawa; Yohko Hikiba; Wataru Shibata; Kei Sakamoto; Ayako Yanai; Yoshihiro Hirata; Keiji Ogura; Susumu Muto; Akiko Itai; Masao Omata
Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis.
Journal of gastroenterology 2009;44(9):935-43.
2008: Shin Wakatsuki; Jun-ichi Suzuki; Masahito Ogawa; Mayumi Masumura; Susumu Muto; Tomoko Shimizu; Kiyoshi Takayama; Akiko Itai; Mitsuaki Isobe
A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration.
Expert opinion on therapeutic targets 2008;12(12):1469-76.
2008: Jun-ichi Suzuki; Masahito Ogawa; Susumu Muto; Akiko Itai; Mitsuaki Isobe
A specific inhibitor of plasminogen activator inhibitor-1 suppresses rat autoimmune myocarditis.
Expert opinion on therapeutic targets 2008;12(11):1313-20.
2008: Jun-ichi Suzuki; Masahito Ogawa; Susumu Muto; Yoichi Yamaguchi; Akiko Itai; Mitsuaki Isobe
The effects of pharmacological PAI-1 inhibition on thrombus formation and neointima formation after arterial injury.
Expert opinion on therapeutic targets 2008;12(7):783-94.
2008: Takanori Ochiai; Yasunori Saito; Tatsuya Saitoh; M Zahidunnabi Dewan; Ayumi Shioya; Maki Kobayashi; Hiroshi Kawachi; Susumu Muto; Akiko Itai; Shin Uota; Yoshinobu Eishi; Naoki Yamamoto; Shinji Tanaka; Shigeki Arii; Shoji Yamaoka
Inhibition of IkappaB kinase beta restrains oncogenic proliferation of pancreatic cancer cells.
Journal of medical and dental sciences 2008;55(1):49-59.
2007: Yasuyuki Onai; Jun-Ichi Suzuki; Yasuhiro Maejima; Go Haraguchi; Susumu Muto; Akiko Itai; Mitsuaki Isobe
Inhibition of NF-{kappa}B improves left ventricular remodeling and cardiac dysfunction after myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2007;292(1):H530-8.
2006: Miho Yamada Mizutani; Kensuke Nakamura; Tazuko Ichinose; Akiko Itai
Starting point to molecular design: efficient automated 3D model builder Key3D.
Chemical & pharmaceutical bulletin 2006;54(12):1680-5.
2006: Go Haraguchi; Jun-Ichi Suzuki; Hisanori Kosuge; Masahito Ogawa; Noritaka Koga; Susumu Muto; Akiko Itai; Hiroyuki Kagechika; Koichi Shudo; Mitsuaki Isobe
A new RXR agonist, HX630, suppresses intimal hyperplasia in a mouse blood flow cessation model.
Journal of molecular and cellular cardiology 2006;41(5):885-92.
2006: Miho Yamada Mizutani; Yoshihiro Takamatsu; Tazuko Ichinose; Kensuke Nakamura; Akiko Itai
Effective handling of induced-fit motion in flexible docking.
Proteins 2006;63(4):878-91.
2005: Yuko Okazaki; Tetsuji Sawada; Katsuya Nagatani; Yoshinori Komagata; Tetsufumi Inoue; Susumu Muto; Akiko Itai; Kazuhiko Yamamoto
Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis.
The Journal of rheumatology 2005;32(8):1440-7.
2005: Hiromi Sato; Seiichi Ishida; Kyoko Toda; Rieko Matsuda; Yuzuru Hayashi; Makoto Shigetaka; Miki Fukuda; Yohko Wakamatsu; Akiko Itai
New approaches to mechanism analysis for drug discovery using DNA microarray data combined with KeyMolnet.
Current drug discovery technologies 2005;2(2):89-98.
2004: Junji Kamon; Toshimasa Yamauchi; Susumu Muto; Sato Takekawa; Yusuke Ito; Yusuke Hada; Wataru Ogawa; Akiko Itai; Masato Kasuga; Kazuyuki Tobe; Takashi Kadowaki
A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance.
Biochemical and biophysical research communications 2004;323(1):242-8.
2004: Miho Yamada Mizutani; Akiko Itai
Efficient method for high-throughput virtual screening based on flexible docking: discovery of novel acetylcholinesterase inhibitors.
Journal of medicinal chemistry 2004;47(20):4818-28.
2004: Yasuyuki Onai; Jun-Ichi Suzuki; Tsunekazu Kakuta; Yasuhiro Maejima; Go Haraguchi; Hiroshi Fukasawa; Susumu Muto; Akiko Itai; Mitsuaki Isobe
Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury.
Cardiovascular research 2004;63(1):51-9.
2001: Toshimasa Yamauchi; Hironori Waki; Junji Kamon; Koji Murakami; Kiyoto Motojima; Kajuro Komeda; Hiroshi Miki; Naoto Kubota; Yasuo Terauchi; Atsushi Tsuchida; Nobuyo Tsuboyama-Kasaoka; N Yamauchi; Tomohiro Ide; W Hori; Shigeaki Kato; Masashi Fukayama; Yasuo Akanuma; Osamu Ezaki; Akiko Itai; Ryozo Nagai; Satoshi Kimura; Kazuyuki Tobe; Hiroyuki Kagechika; Koichi Shudo; Takashi Kadowaki
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes.
The Journal of clinical investigation 2001;108(7):1001-13.
2001: Yoriko Iwata; M Arisawa; R Hamada; Y Kita; M Y Mizutani; N Tomioka; Akiko Itai; Shuichi Miyamoto
Discovery of novel aldose reductase inhibitors using a protein structure-based approach: 3D-database search followed by design and synthesis.
Journal of medicinal chemistry 2001;44(11):1718-28.
2001: Yaeta Endo; Toru Iijima; Kiyoshi Yaguchi; Emiko Kawachi; N Inoue; Hiroyuki Kagechika; A Kubo; Akiko Itai
Structure-Activity study of retinoid agonists bearing substituted dicarba-closo-dodecaborane. Relation between retinoidal activity and conformation of two aromatic nuclei.
Bioorganic & medicinal chemistry letters 2001;11(10):1307-11.
2001: Yaeta Endo; Toru Iijima; Yuko Yamakoshi; Hiroshi Fukasawa; Chisato Miyaura; M Inada; A Kubo; Akiko Itai
Potent estrogen agonists based on carborane as a hydrophobic skeletal structure. A new medicinal application of boron clusters.
Chemistry & biology 2001;8(4):341-55.
2001: Yoriko Iwata; S Naito; Akiko Itai; Shuichi Miyamoto
Protein structure-based de novo design and synthesis of aldose reductase inhibitors.
Drug design and discovery 2001;17(4):349-59.
2000: Keisuke Ohta; Emiko Kawachi; N Inoue; Hiroshi Fukasawa; Yuichi Hashimoto; Akiko Itai; Hiroyuki Kagechika
Retinoidal pyrimidinecarboxylic acids. Unexpected diaza-substituent effects in retinobenzoic acids.
Chemical & pharmaceutical bulletin 2000;48(10):1504-13.
1999: Yaeta Endo; Toru Iijima; Y Amakoshi; A Kubo; Akiko Itai
Structure-activity study of estrogenic agonists bearing dicarba-closo-dodecaborane. Effect of geometry and separation distance of hydroxyl groups at the ends of molecules.
Bioorganic & medicinal chemistry letters 1999;9(23):3313-8.
1999: Yaeta Endo; T Yoshimi; Kenjiro Kimura; Akiko Itai
Protein kinase C modulators bearing dicarba-CLOSO-dodecaborane as a hydrophobic pharmacophore.
Bioorganic & medicinal chemistry letters 1999;9(17):2561-4.
1999: Yaeta Endo; M Shimazu; Hiroshi Fukasawa; Paul Driedger; Kenjiro Kimura; N Tomioka; Akiko Itai; Koichi Shudo
Synthesis, computer modeling and biological evaluation of novel protein kinase C agonists based on a 7-membered lactam moiety.
Bioorganic & medicinal chemistry letters 1999;9(2):173-8.
1998: Y Takamatsu; Akiko Itai
A new method for predicting binding free energy between receptor and ligand.
Proteins 1998;33(1):62-73.
1998: Motohiro Ebisawa; Emiko Kawachi; Hiroshi Fukasawa; Yuichi Hashimoto; Akiko Itai; Koichi Shudo; Hiroyuki Kagechika
Novel thiazolidinedione derivatives with retinoid synergistic activity.
Biological & pharmaceutical bulletin 1998;21(5):547-9.
1998: Yaeta Endo; S Takehana; M Ohno; Paul Driedger; S Stabel; M Y Mizutani; N Tomioka; Akiko Itai; Koichi Shudo
Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation.
Journal of medicinal chemistry 1998;41(9):1476-96.
1998: J Inoue; N Tomioka; Akiko Itai; S Harayama
Proton transfer in benzyl alcohol dehydrogenase during catalysis: alternate proton-relay routes.
Biochemistry 1998;37(10):3305-11.
1997: T Toyoda; R K Brobey; G Sano; T Horii; N Tomioka; Akiko Itai
Lead discovery of inhibitors of the dihydrofolate reductase domain of Plasmodium falciparum dihydrofolate reductase-thymidylate synthase.
Biochemical and biophysical research communications 1997;235(3):515-9.
1996: A Takagi; M Yamada Mizutani; N Tomioka; Akiko Itai
Inhibition mechanisms of staurosporine and H7 to cAMP-dependent protein kinase through docking study.
Chemical & pharmaceutical bulletin 1996;44(3):618-20.
1994: M Y Mizutani; N Tomioka; Akiko Itai
Rational automatic search method for stable docking models of protein and ligand.
Journal of molecular biology 1994;243(2):310-26.
1994: N Tomioka; Akiko Itai
GREEN: a program package for docking studies in rational drug design.
Journal of computer-aided molecular design 1994;8(4):347-66.
1994: I Azumaya; K Yamaguchi; Hiroyuki Kagechika; S Saito; Akiko Itai; Koichi Shudo
[Stereochemistry of benzanilides and N-methylbenzanilides].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1994;114(6):414-30.
1993: Y Nishibata; Akiko Itai
Confirmation of usefulness of a structure construction program based on three-dimensional receptor structure for rational lead generation.
Journal of medicinal chemistry 1993;36(20):2921-8.
1992: N Tomioka; Akiko Itai
Model building of DNA/RNA triple helix containing L-deoxyadenosine.
Biopolymers 1992;32(12):1593-7.
1992: Y Kato; A Inoue; M Yamada; N Tomioka; Akiko Itai
Automatic superposition of drug molecules based on their common receptor site.
Journal of computer-aided molecular design 1992;6(5):475-86.
1992: T Kawai; T Ichinose; Y Endo; Koichi Shudo; Akiko Itai
Active conformation of a tumor promoter, teleocidin. A molecular dynamics study.
Journal of medicinal chemistry 1992;35(12):2248-53.
1991: A Iwamoto; Hiroshi Omote; H Hanada; N Tomioka; Akiko Itai; M Maeda; Masamitsu Futai
Mutations in Ser174 and the glycine-rich sequence (Gly149, Gly150, and Thr156) in the beta subunit of Escherichia coli H(+)-ATPase.
The Journal of biological chemistry 1991;266(25):16350-5.
1990: M Takeyama; K Ihara; Yoshinori Moriyama; T Noumi; K Ida; N Tomioka; Akiko Itai; M Maeda; Masamitsu Futai
The glycine-rich sequence of the beta subunit of Escherichia coli H(+)-ATPase is important for activity.
The Journal of biological chemistry 1990;265(34):21279-84.
1988: Akiko Itai; Y Kato; N Tomioka; Y Iitaka; Y Endo; M Hasegawa; Koichi Shudo; H Fujiki; S Sakai
A receptor model for tumor promoters: rational superposition of teleocidins and phorbol esters.
Proceedings of the National Academy of Sciences of the United States of America 1988;85(11):3688-92.
1987: N Tomioka; Akiko Itai; Y Iitaka
A method for fast energy estimation and visualization of protein-ligand interaction.
Journal of computer-aided molecular design 1987;1(3):197-210.
1986: S Iwasaki; M Namikoshi; H Kobayashi; J Furukawa; S Okuda; Akiko Itai; A Kasuya; Y Iitaka; Z Sato
Studies on macrocyclic lactone antibiotics. VIII. Absolute structures of rhizoxin and a related compound.
The Journal of antibiotics 1986;39(3):424-9.
1984: Y Hitotsuyanagi; K Yamaguchi; K Ogata; N Aimi; S Sakai; Y Koyama; Y Endo; Koichi Shudo; Akiko Itai; Y Iitaka
Elucidation of the structures of olivoretin B and C.
Chemical & pharmaceutical bulletin 1984;32(9):3774-8.