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Kousei Ito
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23
Sugiyama, Yuichi
18
Suzuki, Hiroshi
14
Nakamura, Yusuke
7
Takizawa, Hajime
6
Yamamoto, Kazuhiko
6
Kohyama, Tadashi
6
Kanamitsu, S i
5
Kawasaki, Shin
4
Morita, Yutaka
4
Ohtoshi, Takayuki
4
Iga, Tatsuji
4
Fujiwara, Toshinobu
4
Shimizu, Takao
4
Sawada, Yasufumi
3
Shimada, N
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All Publications
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2009: Ikebuchi Yuki; Takada Tappei; Ito Kousei; Yoshikado Takashi; Anzai Naohiko; Kanai Yoshikatsu; Suzuki Hiroshi
Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(11):1091-107.
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2008: Kobayashi Kazuhiro; Ito Kousei; Takada Tappei; Sugiyama Yuichi; Suzuki Hiroshi
Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.
Pharmacogenetics and genomics 2008;18(9):823-33.
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2008: Ito Kousei
ABCC2/Abcc2 transport property in different species and its modulation by heterogeneous factors.
Drug metabolism and pharmacokinetics 2008;23(6):394-405.
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2007: Yamamoto Takehito; Ito Kousei; Honma Masashi; Takada Tappei; Suzuki Hiroshi
Cholesterol-lowering effect of ezetimibe in uridine diphosphate glucuronosyltransferase 1A-deficient (Gunn) rats.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1455-8.
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2004: Sasaki Makoto; Suzuki Hiroshi; Aoki Jun; Ito Kousei; Meier Peter J; Sugiyama Yuichi
Prediction of in vivo biliary clearance from the in vitro transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II monolayer expressing both rat organic anion transporting polypeptide 4 and multidrug resistance associated protein 2.
Molecular pharmacology 2004;66(3):450-9.
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2002: Hasegawa Maki; Kusuhara Hiroyuki; Sugiyama Daisuke; Ito Kousei; Ueda Shirou; Endou Hitoshi; Sugiyama Yuichi
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
The Journal of pharmacology and experimental therapeutics 2002;300(3):746-53.
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2002: Sasaki Makoto; Suzuki Hiroshi; Ito Kousei; Abe Takaaki; Sugiyama Yuichi
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2).
The Journal of biological chemistry 2002;277(8):6497-503.
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2001: Miyanaga A; Fushinobu S; Ito K; Wakagi T
Crystal structure of cobalt-containing nitrile hydratase.
Biochemical and biophysical research communications 2001;288(5):1169-74.
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2001: Ito K; Suzuki H; Sugiyama Y
Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate.
American journal of physiology. Gastrointestinal and liver physiology 2001;281(4):G1034-43.
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2001: Gong F; Ito K; Nakamura Y; Yanofsky C
The mechanism of tryptophan induction of tryptophanase operon expression: tryptophan inhibits release factor-mediated cleavage of TnaC-peptidyl-tRNA(Pro).
Proceedings of the National Academy of Sciences of the United States of America 2001;98(16):8997-9001.
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2001: Ito K; Suzuki H; Sugiyama Y
Charged amino acids in the transmembrane domains are involved in the determination of the substrate specificity of rat Mrp2.
Molecular pharmacology 2001;59(5):1077-85.
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2001: Hirota N; Ito K; Iwatsubo T; Green C E; Tyson C A; Shimada N; Suzuki H; Sugiyama Y
In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans.
Biopharmaceutics & drug disposition 2001;22(2):53-71.
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2001: Akita H; Suzuki H; Ito K; Kinoshita S; Sato N; Takikawa H; Sugiyama Y
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump.
Biochimica et biophysica acta 2001;1511(1):7-16.
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2001: Fujiwara T; Ito K; Nakamura Y
Functional mapping of ribosome-contact sites in the ribosome recycling factor: a structural view from a tRNA mimic.
RNA (New York, N.Y.) 2001;7(1):64-70.
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2001: Nakamura Y; Uno M; Toyoda T; Fujiwara T; Ito K
Protein tRNA mimicry in translation termination.
Cold Spring Harbor symposia on quantitative biology 2001;66():469-75.
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2000: Toyoda T; Tin O F; Ito K; Fujiwara T; Kumasaka T; Yamamoto M; Garber M B; Nakamura Y
Crystal structure combined with genetic analysis of the Thermus thermophilus ribosome recycling factor shows that a flexible hinge may act as a functional switch.
RNA (New York, N.Y.) 2000;6(10):1432-44.
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2000: Kawahara I; Kato Y; Suzuki H; Achira M; Ito K; Crespi C L; Sugiyama Y
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in gene transfectant systems.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(10):1238-43.
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2000: Sawada T; Hashimoto S; Tohma S; Nishioka Y; Nagai T; Sato T; Ito K; Inoue T; Iwata M; Yamamoto K
Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614.
Immunopharmacology 2000;49(3):285-94.
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2000: Nakamura Y; Ito K; Ehrenberg M
Mimicry grasps reality in translation termination.
Cell 2000;101(4):349-52.
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2000: Kanamitsu S; Ito K; Green C E; Tyson C A; Shimada N; Sugiyama Y
Prediction of in vivo interaction between triazolam and erythromycin based on in vitro studies using human liver microsomes and recombinant human CYP3A4.
Pharmaceutical research 2000;17(4):419-26.
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2000: Komatsu K; Ito K; Nakajima Y; Kanamitsu S i; Imaoka S; Funae Y; Green C E; Tyson C A; Shimada N; Sugiyama Y
Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):475-81.
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2000: Kanamitsu S I; Ito K; Okuda H; Ogura K; Watabe T; Muro K; Sugiyama Y
Prediction of in vivo drug-drug interactions based on mechanism-based inhibition from in vitro data: inhibition of 5-fluorouracil metabolism by (E)-5-(2-Bromovinyl)uracil.
Drug metabolism and disposition: the biological fate of chemicals 2000;28(4):467-74.
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2000: Kanamitsu S; Ito K; Sugiyama Y
Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.
Pharmaceutical research 2000;17(3):336-43.
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2000: Ito K; Uno M; Nakamura Y
A tripeptide 'anticodon' deciphers stop codons in messenger RNA.
Nature 2000;403(6770):680-4.
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2000: Desaki M; Takizawa H; Ohtoshi T; Kasama T; Kobayashi K; Sunazuka T; Omura S; Yamamoto K; Ito K
Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells.
Biochemical and biophysical research communications 2000;267(1):124-8.
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1999: Karamyshev A L; Karamysheva Z N; Ito K; Matsufuji S; Nakamura Y
Overexpression and purification of recombinant eRF1 proteins of rabbit and Tetrahymena thermophila.
Biochemistry. Biokhimii?a 1999;64(12):1391-400.
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1999: Horie R; Gattei V; Ito K; Imajo-Ohmi S; Tange T; Miyauchi J; Pinto A; Degan M; De Iuliis A; Tassan Mazzocco F; Rossi F M; Higashihara M; Watanabe T
Frequent expression of the variant CD30 in human malignant myeloid and lymphoid neoplasms.
The American journal of pathology 1999;155(6):2029-41.
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1999: Karamyshev A L; Ito K; Nakamura Y
Polypeptide release factor eRF1 from Tetrahymena thermophila: cDNA cloning, purification and complex formation with yeast eRF3.
FEBS letters 1999;457(3):483-8.
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1999: Nishino J; Suzuki H; Sugiyama D; Kitazawa T; Ito K; Hanano M; Sugiyama Y
Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein.
The Journal of pharmacology and experimental therapeutics 1999;290(1):289-94.
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1999: Yoshimura K; Ito K; Nakamura Y
Amber (UAG) suppressors affected in UGA/UAA-specific polypeptide release factor 2 of bacteria: genetic prediction of initial binding to ribosome preceding stop codon recognition.
Genes to cells : devoted to molecular & cellular mechanisms 1999;4(5):253-66.
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1999: Kohyama T; Takizawa H; Kawasaki S; Akiyama N; Sato M; Ito K; Yamamoto K
A potent immunosuppressant FK506 inhibits IL-8 expression in human eosinophils.
Molecular cell biology research communications : MCBRC 1999;1(1):72-7.
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1999: Kohyama T; Takizawa H; Kawasaki S; Akiyama N; Sato M; Ito K
Fourteen-member macrolides inhibit interleukin-8 release by human eosinophils from atopic donors.
Antimicrobial agents and chemotherapy 1999;43(4):907-11.
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1999: Fujiwara T; Ito K; Nakayashiki T; Nakamura Y
Amber mutations in ribosome recycling factors of Escherichia coli and Thermus thermophilus: evidence for C-terminal modulator element.
FEBS letters 1999;447(2-3):297-302.
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1999: Kouzuki H; Suzuki H; Ito K; Ohashi R; Sugiyama Y
Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1999;288(2):627-34.
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1999: Achira M; Suzuki H; Ito K; Sugiyama Y
Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4.
AAPS pharmSci 1999;1(4):E18.
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1998: Kinoshita S; Suzuki H; Ito K; Kume K; Shimizu T; Sugiyama Y
Transfected rat cMOAT is functionally expressed on the apical membrane in Madin-Darby canine kidney (MDCK) cells.
Pharmaceutical research 1998;15(12):1851-6.
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1998: Sugiyama Y; Ito K
Future prospects for toxicokinetics: prediction of drug disposition and adverse effects in humans from in vitro measurements of drug metabolism, transport and binding.
The Journal of toxicological sciences 1998;23 Suppl 4():647-52.
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1998: Takafuji S; Tadokoro K; Ito K; Nakagawa T
Release of granule proteins from human eosinophils stimulated with mast-cell mediators.
Allergy 1998;53(10):951-6.
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1998: Takafuji S; Shoji S; Ito K; Yamamoto K; Nakagawa T
Eosinophil degranulation in the presence of lung fibroblasts.
International archives of allergy and immunology 1998;117 Suppl 1():52-4.
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1998: Ito K; Iwatsubo T; Kanamitsu S; Ueda K; Suzuki H; Sugiyama Y
Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.
Pharmacological reviews 1998;50(3):387-412.
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1998: Ito K; Ebihara K; Nakamura Y
The stretch of C-terminal acidic amino acids of translational release factor eRF1 is a primary binding site for eRF3 of fission yeast.
RNA (New York, N.Y.) 1998;4(8):958-72.
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1998: Kouzuki H; Suzuki H; Ito K; Ohashi R; Sugiyama Y
Contribution of sodium taurocholate co-transporting polypeptide to the uptake of its possible substrates into rat hepatocytes.
The Journal of pharmacology and experimental therapeutics 1998;286(2):1043-50.
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1998: Takizawa H; Desaki M; Ohtoshi T; Kawasaki S; Kohyama T; Sato M; Nakajima J; Yanagisawa M; Ito K
Erythromycin and clarithromycin attenuate cytokine-induced endothelin-1 expression in human bronchial epithelial cells.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1998;12(1):57-63.
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1998: Ito K; Uno M; Nakamura Y
Single amino acid substitution in prokaryote polypeptide release factor 2 permits it to terminate translation at all three stop codons.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(14):8165-9.
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1998: Koshino T; Takano S; Houjo T; Sano Y; Kudo K; Kihara H; Kitani S; Takaishi T; Hirai K; Ito K; Morita Y
Expression of 5-lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics.
Biochemical and biophysical research communications 1998;247(2):510-3.
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1998: Nakamura Y; Ito K
How protein reads the stop codon and terminates translation.
Genes to cells : devoted to molecular & cellular mechanisms 1998;3(5):265-78.
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1998: Haraguchi K; Ito K; Kotaki H; Sawada Y; Iga T
Catalepsy induced by calcium channel blockers in mice.
Biopharmaceutics & drug disposition 1998;19(2):115-22.
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1998: Horie R; Aizawa S; Nagai M; Ito K; Higashihara M; Ishida T; Inoue J; Watanabe T
A novel domain in the CD30 cytoplasmic tail mediates NFkappaB activation.
International immunology 1998;10(2):203-10.
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1998: Ito K; Suzuki H; Hirohashi T; Kume K; Shimizu T; Sugiyama Y
Functional analysis of a canalicular multispecific organic anion transporter cloned from rat liver.
The Journal of biological chemistry 1998;273(3):1684-8.
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1998: Ito K; Iwatsubo T; Kanamitsu S; Nakajima Y; Sugiyama Y
Quantitative prediction of in vivo drug clearance and drug interactions from in vitro data on metabolism, together with binding and transport.
Annual review of pharmacology and toxicology 1998;38():461-99.
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1997: Honda Z i; Suzuki T; Hirose N; Aihara M; Shimizu T; Nada S; Okada M; Ra C; Morita Y; Ito K
Roles of C-terminal Src kinase in the initiation and the termination of the high affinity IgE receptor-mediated signaling.
The Journal of biological chemistry 1997;272(41):25753-60.
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1997: Ito K; Momose T; Kotaki H; Kojima Y; Yamamoto K; Katashima M; Sawada Y; Sasaki Y; Iga T
Pharmacokinetic analysis of benzodiazepine receptor binding of [123I]iomazenil in human brain.
Pharmaceutical research 1997;14(8):999-1003.
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1997: Takizawa H; Desaki M; Ohtoshi T; Kawasaki S; Kohyama T; Sato M; Tanaka M; Kasama T; Kobayashi K; Nakajima J; Ito K
Erythromycin modulates IL-8 expression in normal and inflamed human bronchial epithelial cells.
American journal of respiratory and critical care medicine 1997;156(1):266-71.
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1997: Haraguchi K; Ito K; Kotaki H; Sawada Y; Iga T
Prediction of drug-induced catalepsy based on dopamine D1, D2, and muscarinic acetylcholine receptor occupancies.
Drug metabolism and disposition: the biological fate of chemicals 1997;25(6):675-84.
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1997: Ito K; Nakamura Y
Cloning and overexpression of polypeptide release factor 1 of Thermus thermophilus.
Biochimie 1997;79(5):287-92.
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1997: Ito K; Asakura A; Yamada Y; Nakamura K; Sawada Y; Iga T
Prediction of the therapeutic dose for benzodiazepine anxiolytics based on receptor occupancy theory.
Biopharmaceutics & drug disposition 1997;18(4):293-303.
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1997: Sato M; Takizawa H; Kohyama T; Ohtoshi T; Takafuji S; Kawasaki S; Tohma S; Ishii A; Shoji S; Ito K
Eosinophil adhesion to human bronchial epithelial cells: regulation by cytokines.
International archives of allergy and immunology 1997;113(1-3):203-5.
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1997: Mato T; Masuko K; Misaki Y; Hirose N; Ito K; Takemoto Y; Izawa K; Yamamori S; Kato T; Nishioka K; Yamamoto K
Correlation of clonal T cell expansion with disease activity in systemic lupus erythematosus.
International immunology 1997;9(4):547-54.
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1997: Izumi S; Hirai K; Miyamasu M; Takahashi Y; Misaki Y; Takaishi T; Morita Y; Matsushima K; Ida N; Nakamura H; Kasahara T; Ito K
Expression and regulation of monocyte chemoattractant protein-1 by human eosinophils.
European journal of immunology 1997;27(4):816-24.
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1997: Mori A; Kaminuma O; Suko M; Inoue S; Ohmura T; Hoshino A; Asakura Y; Miyazawa K; Yokota T; Okumura Y; Ito K; Okudaira H
Two distinct pathways of interleukin-5 synthesis in allergen-specific human T-cell clones are suppressed by glucocorticoids.
Blood 1997;89(8):2891-900.
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1997: Mori A; Suko M; Kaminuma O; Inoue S; Ohmura T; Hoshino A; Asakura Y; Terada E; Miyazawa K; Nosaka C; Okumura Y; Ito K; Okudaira H
IL-2-induced IL-5 synthesis, but not proliferation, of human CD4+ T cells is suppressed by FK506.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(8):3659-65.
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1997: Yamada H; Hirai K; Miyamasu M; Iikura M; Misaki Y; Shoji S; Takaishi T; Kasahara T; Morita Y; Ito K
Eotaxin is a potent chemotaxin for human basophils.
Biochemical and biophysical research communications 1997;231(2):365-8.
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1997: Sawada T; Hashimoto S; Furukawa H; Tohma S; Inoue T; Ito K
Generation of reactive oxygen species is required for bucillamine, a novel anti-rheumatic drug, to induce apoptosis in concert with copper.
Immunopharmacology 1997;35(3):195-202.
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1997: Ito K; Suzuki H; Hirohashi T; Kume K; Shimizu T; Sugiyama Y
Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR.
The American journal of physiology 1997;272(1 Pt 1):G16-22.
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1997: Kohyama T; Takizawa H; Akiyama N; Sato M; Kawasaki S; Ito K
A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils.
Biochemical and biophysical research communications 1997;230(1):125-8.
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1997: Aizawa S; Nakano H; Ishida T; Horie R; Nagai M; Ito K; Yagita H; Okumura K; Inoue J; Watanabe T
Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation.
The Journal of biological chemistry 1997;272(4):2042-5.
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1997: Miyoshi H; Ito K; Sakai N; Mizushima J; Okamoto K; Hori H; Nishino T; Wakiyama M; Miura K
Expression of Xenopus laevis translation initiation factor 4E (eIF-4E) by baculovirus-insect cell system.
Nucleic acids symposium series 1997;(37):191-2.
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